aortic aneurysm

Summary

Summary: Aneurysm of the aorta.

Top Publications

  1. ncbi Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
    Ingrid M B H van de Laar
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 43:121-6. 2011
  2. pmc Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism
    Jennifer P Habashi
    Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 332:361-5. 2011
  3. ncbi Aneurysm syndromes caused by mutations in the TGF-beta receptor
    Bart L Loeys
    McKusick Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, and the Kennedy Krieger Institute, Baltimore, USA
    N Engl J Med 355:788-98. 2006
  4. ncbi Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD)
    T T Tsai
    Health Services Research and Development Center, Denver Veterans Affairs Medical Center, 1055 Clermont Street, Denver, CO 80220, USA
    Eur J Vasc Endovasc Surg 37:149-59. 2009
  5. pmc Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice
    Tammy M Holm
    Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 332:358-61. 2011
  6. ncbi Aortic aneurysm and dissection in patients with biopsy-proven giant cell arteritis from northwestern Spain: a population-based study
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 83:335-41. 2004
  7. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
  8. ncbi Simple risk models to predict surgical mortality in acute type A aortic dissection: the International Registry of Acute Aortic Dissection score
    Vincenzo Rampoldi
    Cardiovascular Center E Malan, Policlinico S Donato, S Donato Milanese, Italy
    Ann Thorac Surg 83:55-61. 2007
  9. ncbi The fate of the distal aorta after repair of acute type A aortic dissection
    James C Halstead
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 133:127-35. 2007
  10. ncbi Incidence of aortic complications in patients with bicuspid aortic valves
    Hector I Michelena
    Division of Cardiovascular Disease, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA 306:1104-12. 2011

Research Grants

  1. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
  2. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
  3. Tissue Factor &Clot Formation In Abdominal Aortic Aneurysm
    ALBERT PHILLIP OWENS; Fiscal Year: 2013
  4. Angiotensin II uncoupling of eNOS in hypertension
    HUA LINDA CAI; Fiscal Year: 2013
  5. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
  6. HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
    Hugh Rosen; Fiscal Year: 2010
  7. Atomic Force Microscopic Studies of Dissecting Aneurysm
    Paul J Boor; Fiscal Year: 2013
  8. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
  9. Smooth Muscle Differentiation and Maturation
    Shiyou Chen; Fiscal Year: 2013
  10. Syndecan-1 in Aortic Aneurysm Formation
    Elliot Chaikof; Fiscal Year: 2012

Detail Information

Publications342 found, 100 shown here

  1. ncbi Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
    Ingrid M B H van de Laar
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 43:121-6. 2011
    ..Our findings endorse the TGF-β pathway as the primary pharmacological target for the development of new treatments for aortic aneurysms and osteoarthritis...
  2. pmc Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism
    Jennifer P Habashi
    Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 332:361-5. 2011
    Angiotensin II (AngII) mediates progression of aortic aneurysm, but the relative contribution of its type 1 (AT1) and type 2 (AT2) receptors remains unknown...
  3. ncbi Aneurysm syndromes caused by mutations in the TGF-beta receptor
    Bart L Loeys
    McKusick Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, and the Kennedy Krieger Institute, Baltimore, USA
    N Engl J Med 355:788-98. 2006
    ....
  4. ncbi Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD)
    T T Tsai
    Health Services Research and Development Center, Denver Veterans Affairs Medical Center, 1055 Clermont Street, Denver, CO 80220, USA
    Eur J Vasc Endovasc Surg 37:149-59. 2009
    ..In this article we summarize the key lessons learned from this multi-national registry of patients presenting with acute aortic dissection...
  5. pmc Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice
    Tammy M Holm
    Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 332:358-61. 2011
    ..Thus, noncanonical (Smad-independent) TGFβ signaling is a prominent driver of aortic disease in MFS mice, and inhibition of the ERK1/2 or JNK1 pathways is a potential therapeutic strategy for the disease...
  6. ncbi Aortic aneurysm and dissection in patients with biopsy-proven giant cell arteritis from northwestern Spain: a population-based study
    Miguel A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Medicine (Baltimore) 83:335-41. 2004
    ..We assessed the incidence and predictors of aortic aneurysm and dissection in patients with biopsy-proven GCA from the Lugo region of northwestern Spain and compared the ..
  7. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
    b>Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1...
  8. ncbi Simple risk models to predict surgical mortality in acute type A aortic dissection: the International Registry of Acute Aortic Dissection score
    Vincenzo Rampoldi
    Cardiovascular Center E Malan, Policlinico S Donato, S Donato Milanese, Italy
    Ann Thorac Surg 83:55-61. 2007
    ..We report a predictive score to identify risk of death that may be helpful to assist surgeons who are considering whether to proceed with surgical correction in the case of patients in extreme clinical risk...
  9. ncbi The fate of the distal aorta after repair of acute type A aortic dissection
    James C Halstead
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 133:127-35. 2007
    ..The residual aorta's behavior after repair of acute type A dissection is incompletely understood. We analyzed segmental growth rates, distal reoperation, and factors influencing long-term survival...
  10. ncbi Incidence of aortic complications in patients with bicuspid aortic valves
    Hector I Michelena
    Division of Cardiovascular Disease, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA 306:1104-12. 2011
    ..Bicuspid aortic valve (BAV), the most common congenital heart defect, has been thought to cause frequent and severe aortic complications; however, long-term, population-based data are lacking...
  11. ncbi Clinical, diagnostic, and management perspectives of aortic dissection
    Ijaz A Khan
    Division of Cardiology, Department of Medicine, Creighton University School of Medicine, Omaha, NB, USA
    Chest 122:311-28. 2002
    ..The clinical, diagnostic, and management perspectives on aortic dissection and its variants, aortic intramural hematoma and atherosclerotic aortic ulcer, are reviewed...
  12. ncbi Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice
    Katsuhiro Hanada
    Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands
    Circ Res 100:738-46. 2007
    ..Our results show that the dosage of a single gene can determine the severity of aneurysm formation and imply that disturbed TGF-beta signaling underlies multiple aneurysm phenotypes...
  13. ncbi Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway
    Delphine Gomez
    INSERM, U698, Paris, F 75018, France
    J Pathol 218:131-42. 2009
    ..In conclusion, this study highlights independent dysregulations of TGF-beta retention and Smad2 signalling in syndromic and non-syndromic aneurysms of the ascending aorta...
  14. ncbi The results of total arch graft implantation with open stent-graft placement for type A aortic dissection
    Masaaki Kato
    Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Saitama Medical School, Saitama, Japan
    J Thorac Cardiovasc Surg 124:531-40. 2002
    ..To address this problem, we have developed a new method for type A aortic dissection: total arch graft implantation with open-style stent-graft placement...
  15. pmc Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm
    Alexander J Doyle
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Genet 44:1249-54. 2012
    ..growth factor (TGF)-β signaling has been implicated in the pathogenesis of syndromic presentations of aortic aneurysm, including Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS)...
  16. pmc S100A12 mediates aortic wall remodeling and aortic aneurysm
    Marion Hofmann Bowman
    Department of Medicine, Section of Cardiology, University of Chicago, Chicago, IL 60637, USA
    Circ Res 106:145-54. 2010
    ..RAGE has been extensively implicated in inflammatory states such as atherosclerosis, but the role of S100A12 as its ligand is less clear...
  17. ncbi Overexpression of transforming growth factor-beta is associated with increased hyaluronan content and impairment of repair in Marfan syndrome aortic aneurysm
    Maria Nataatmadja
    Department of Medicine, The University of Queensland, Prince Charles Hospital, Brisbane 4032, Australia
    Circulation 114:I371-7. 2006
    Marfan syndrome (MFS), a condition caused by fibrillin-1 gene mutation is associated with aortic aneurysm that shows elastic lamellae disruption, accumulation of glycosaminoglycans, and vascular smooth muscle cell (VSMC) apoptosis with ..
  18. ncbi Outcomes in adults with bicuspid aortic valves
    Nikolaos Tzemos
    Peter Munk Cardiac Centre and Toronto Congenital Cardiac Centre for Adults, University Health Network, University of Toronto, Toronto, Ontario, Canada
    JAMA 300:1317-25. 2008
    ..Bicuspid aortic valve is the most common congenital cardiac anomaly in the adult population. Cardiac outcomes in a contemporary population of adults with bicuspid aortic valve have not been systematically determined...
  19. ncbi Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Involvement of Porphyromonas gingivalis in the development of human aortic aneurysm
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    J Pharmacol Sci 113:115-9. 2010
    ..gingivalis infection are different from those present in non-infected patients. The major characteristic of P. gingivalis infection associated with aneurysms is smooth muscle cell proliferation in the distal aorta...
  20. ncbi Reporting standards for endovascular aortic aneurysm repair
    Elliot L Chaikof
    Emory University, 21639 Pierce Drive, Rm 5105, Atlanta, GA 30322, USA
    J Vasc Surg 35:1048-60. 2002
  21. ncbi Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery
    Veronica Jackson
    Cardiothoracic Surgery Unit at the Department of Molecular Medicine and Surgery at Karolinska Institutet and Karolinska University Hospital
    Eur J Cardiothorac Surg 40:e118-24. 2011
    ....
  22. pmc Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, U S A
    Clin Sci (Lond) 118:681-9. 2010
    ..This new model of ascending aortic aneurysms has pathology that differs markedly from AngII-induced atherosclerosis or AAAs, but all vascular pathologies were attenuated by CCR2 deficiency...
  23. ncbi Incidence and predictors of large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years
    Dirk M Nuenninghoff
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Rheum 48:3522-31. 2003
    To determine the incidence and predictors of large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis (GCA).
  24. pmc Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factors
    A E Warren
    Division of Pediatric Cardiology, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Heart 92:1496-500. 2006
    ..To describe the incidence and rate of dilatation of the ascending aorta in children with bicuspid aortic valve (BAV) and to determine factors that predict rapid aortic dilatation...
  25. ncbi Does the arterial cannulation site for circulatory arrest influence stroke risk?
    Lars G Svensson
    Department of Thoracic Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 78:1274-84; discussion 1274-84. 2004
    ..We investigated whether axillary/subclavian artery inflow with a side graft decreases the risk of stroke versus cannulation at other sites during hypothermic circulatory arrest...
  26. pmc Altered TGFbeta signaling and cardiovascular manifestations in patients with autosomal recessive cutis laxa type I caused by fibulin-4 deficiency
    Marjolijn Renard
    Center for Medical Genetics, University Hospital Ghent, De Pintelaan 185, Ghent, Belgium
    Eur J Hum Genet 18:895-901. 2010
    ..This confirms the important role of fibulin-4 in vascular elastic fiber assembly. Furthermore, we provide the first evidence for the involvement of altered TGFbeta signaling in the pathogenesis of FBLN4 mutations in humans...
  27. ncbi [Screening for chronic Q fever in symptomatic patients with an aortic aneurysm or prosthesis]
    Peter C Wever
    Jeroen Bosch Ziekenhuis, s Hertogenbosch, The Netherlands
    Ned Tijdschr Geneeskd 154:A2122. 2010
    ..A hospital screening programme for chronic Q fever in patients with aortic aneurysm revealed chronic Q fever...
  28. ncbi A doxycycline loaded, controlled-release, biodegradable fiber for the treatment of aortic aneurysms
    A Yamawaki-Ogata
    Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biomaterials 31:9554-64. 2010
    The pathogenesis of aortic aneurysm (AA) is characterized by degradation of extracellular matrix with increased matrix metalloproteinases (MMPs) and inflammatory reaction...
  29. ncbi Imaging of aortic dissection by helical computed tomography (CT)
    Serge Willoteaux
    Department of Cardiovascular Radiology, Hopital Cardiologique, CHRU de Lille, 59037, Lille, France
    Eur Radiol 14:1999-2008. 2004
    ..Imaging of the post-surgical aorta and of chronic dissection is outlined. Intra-mural hematoma and penetrating aortic ulcer are subtypes of aortic dissection, and their appearances on CT scanning are also presented...
  30. pmc External aortic root support for Marfan syndrome: early clinical results in the first 20 recipients with a bespoke implant
    John Pepper
    Royal Brompton Hospital London SW3 6NP, UK
    J R Soc Med 103:370-5. 2010
    ..For patients having aortic root surgery at the same institution, in the same time frame as the first 10 patients, clinical data were retrieved on Marfan and other patients having aortic root replacement to serve as a reference data...
  31. ncbi Surgical outcome of acute type A aortic dissection: analysis of risk factors
    Teruhisa Kazui
    First Department of Surgery, Hamamatsu University School of Medicine, Japan
    Ann Thorac Surg 74:75-81; discussion 81-2. 2002
    ..The aim of this study was to assess the risk factors for the early and late outcome of the surgical treatment of acute type A aortic dissection...
  32. ncbi Surgical management of aortic root disease in Marfan syndrome: a systematic review and meta-analysis
    Umberto Benedetto
    Department of Cardiac Surgery, University of Rome Sapienza, Policlinico S Andrea, Rome, Italy
    Heart 97:955-8. 2011
    ..Surgical treatment of aortic root aneurysm in Marfan syndrome (MFS) patients...
  33. ncbi Can the principles of evidence-based medicine be applied to the treatment of aortic dissections?
    Truls Myrmel
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Cardiothorac Surg 25:236-42; discussion 242-5. 2004
    ....
  34. ncbi Ascending aortic curvature as an independent risk factor for type A dissection, and ascending aortic aneurysm formation: a mathematical model
    Michael P Poullis
    Department of Cardiothoracic Surgery, Thomas Drive, Liverpool L14 3PE, United Kingdom
    Eur J Cardiothorac Surg 33:995-1001. 2008
    ....
  35. pmc Intravenous administration of mesenchymal stem cells prevents angiotensin II-induced aortic aneurysm formation in apolipoprotein E-deficient mouse
    Xian Ming Fu
    Department of Cardiothoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya Aichi 466 8550, Japan
    J Transl Med 11:175. 2013
    ..of bone marrow-derived MSCs (BM-MSCs) sheet by laparotomy attenuated angiotensin II (AngII)-induced aortic aneurysm (AA) growth in apolipoprotein E-deficient (apoE-/-) mice through anti-inflammation effects...
  36. pmc An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall
    Kirsten A Turlo
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 365:23-35. 2012
    ..It further establishes a critical role of β1 integrin in the protection against aneurysms that is particularly confined to the ascending aorta and its branches...
  37. ncbi Influence of operative strategy for the aortic arch in DeBakey type I aortic dissection: analysis of the German Registry for Acute Aortic Dissection Type A
    Jerry Easo
    Department of Cardiothoracic and Vascular Surgery, Klinikum Oldenburg, Germany
    J Thorac Cardiovasc Surg 144:617-23. 2012
    ..Our goal was to analyze the operative strategy for treatment of type I DeBakey aortic dissection from the German Registry for Acute Aortic Dissection Type A (GERAADA) data...
  38. ncbi Mechanical behaviour and rupture of normal and pathological human ascending aortic wall
    C M García-Herrera
    Departamento de Ingeniería Mecánica, Universidad de Santiago de Chile, USACH, Av Bernardo O Higgins 3363, Santiago de Chile, Chile
    Med Biol Eng Comput 50:559-66. 2012
    ..In contrast, the physiological operation of pathologic vessels lays in the stiff part of the response curve, losing part of its function of damping the pressure waves from the heart...
  39. ncbi Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice
    Ryotaro Hashizume
    Department of Cardiac Surgery, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    J Vasc Surg 54:1743-52. 2011
    b>Aortic aneurysm (AA) is associated with loss of elastin and structural integrity, accompanied by increased matrix metalloproteinase (MMP) expression...
  40. ncbi Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection
    Masatoshi Akiyama
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Virchows Arch 448:811-21. 2006
    ....
  41. ncbi Synchronized epiaortic two-dimensional and color Doppler echocardiographic guidance enables routine ascending aortic cannulation in type A acute aortic dissection
    Yoshito Inoue
    Department of Cardiovascular Surgery, Hiratsuka, City Hospital, Kanagawa, Japan
    J Thorac Cardiovasc Surg 141:354-60. 2011
    ..It has not been used routinely, however, because of the disruption caused to the aorta. We evaluated the safety and efficacy of routine cannulation of the dissected aorta for the repair of type A dissection...
  42. ncbi Secondary procedures after aortic aneurysm repair with fenestrated and branched endografts
    Nicola Troisi
    Department of Vascular Surgery, St Franziskus Hospital, Munster, Germany
    J Endovasc Ther 18:146-53. 2011
    ..To investigate the secondary procedures in patients with previous endovascular aortic repair by fenestrated or branched stent-grafts for aneurysms involving the renal and visceral vessels...
  43. ncbi Histopathological grading of ascending aortic aneurysm: comparison of patients with bicuspid versus tricuspid aortic valve
    J F Matthias Bechtel
    Department of Cardiac Surgery, University Hospital Lubeck, Lubeck, Germany
    J Heart Valve Dis 12:54-9; discussion 59-61. 2003
    Bicuspid aortic valve (BAV) is a common inherited condition that is often accompanied by ascending aortic aneurysm. A high level of histological wall abnormalities was reported to be present in non-dilated aortas of patients with BAV...
  44. ncbi Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa
    Majed Dasouki
    Division of Genetics, Endocrinology and Metabolism, Department of Pediatrics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Med Genet A 143:2635-41. 2007
    ..Here we report on a female newborn with apparently long fingers, aortic aneurysm, tortuous pulmonary arteries and mild generalized lax skin...
  45. ncbi Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves
    John S Ikonomidis
    Department of Cardiothoracic Surgical Research, Division of Cardiothoracic Surgery, Medical University of South Carolina, Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA
    J Thorac Cardiovasc Surg 133:1028-36. 2007
    ..Matrix metalloproteinases and their endogenous inhibitors have been causally linked to ascending thoracic aortic aneurysm formation...
  46. ncbi Should the proximal arch be routinely replaced in patients with bicuspid aortic valve disease and ascending aortic aneurysm?
    Chan B Park
    Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 142:602-7. 2011
    ..Data support an aggressive approach to replacement of the ascending aorta. However, the natural history of the unreplaced aortic arch is unknown, and some have advocated routine replacement of the proximal arch in this setting...
  47. ncbi Application of triple-branched stent graft for Stanford type A aortic dissection: potential risks
    Kangjun Shen
    Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    Eur J Cardiothorac Surg 41:e12-7. 2012
    ..However, we found some potential risks, in our experience, of this technique. We compared this technique with total arch replacement combined with stented elephant trunk implantation in patients with acute Stanford type A dissection...
  48. ncbi The diagnosis of aortic dissection by emergency medicine ultrasound
    John P Fojtik
    Department of Emergency Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Emerg Med 32:191-6. 2007
    ..This article reports the use of Emergency ultrasound in a series of five aortic dissections discovered with a limited, yet timely viewing of the aorta and heart by emergency physicians...
  49. ncbi Idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pericarditis--retrospective analysis of 11 case histories
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Cardiol 59:139-46. 2012
    Retroperitoneal fibrosis, inflammatory aortic aneurysm, and pericardial and mediastinal fibrosis are characterized by infiltration of immuno-inflammatory cells and deposition of thickened fibrous tissues...
  50. ncbi Should the "elephant trunk" be skeletonized? Total arch replacement combined with stented elephant trunk implantation for Stanford type A aortic dissection
    Zhi Gang Liu
    Department of Cardiovascular Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academe of Medical Science and Peking Union Medical College, Beijing, China
    J Thorac Cardiovasc Surg 131:107-13. 2006
    ....
  51. ncbi Ultrasound diagnosis of type a aortic dissection
    Alisha M Perkins
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Emerg Med 38:490-3. 2010
    ....
  52. ncbi Multidetector CT of Aortic Dissection: A Pictorial Review
    Michelle A McMahon
    Department of Radiology, City Hospital Campus, Nottingham University Hospitals NHS Trust, Hucknall Rd, Nottingham NG51PB, England
    Radiographics 30:445-60. 2010
    ....
  53. ncbi CT colonography to screen for colorectal cancer and aortic aneurysm in the Medicare population: cost-effectiveness analysis
    Perry J Pickhardt
    Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792 3252, USA
    AJR Am J Roentgenol 192:1332-40. 2009
    ..CTC can also accurately detect abdominal aortic aneurysm (AAA)...
  54. ncbi Aortic dilatation and dissection in Turner syndrome
    Lea Ann Matura
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Circulation 116:1663-70. 2007
    ..It is unknown whether aortic dilatation precedes acute aortic dissection in TS and, if so, what specific diameter predicts impending deterioration...
  55. ncbi Axillary artery cannulation improves operative results for acute type a aortic dissection
    Yoshimasa Moizumi
    Division of Cardiovascular Surgery, Sendai City Medical Center, Sendai, Japan
    Ann Thorac Surg 80:77-83. 2005
    ..This study was undertaken to identify preoperative and postoperative predictors of hospital death of patients with acute type A aortic dissection...
  56. ncbi Cerebral protection during surgery for acute aortic dissection type A: results of the German Registry for Acute Aortic Dissection Type A (GERAADA)
    Tobias Krüger
    Department of Thoracic, Cardiac and Vascular Surgery, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen, Germany
    Circulation 124:434-43. 2011
    ..Cerebral protection during surgery for acute aortic dissection type A relies on hypothermic circulatory arrest, either alone or in conjunction with cerebral perfusion...
  57. ncbi Partial thrombosis of the false lumen in patients with acute type B aortic dissection
    Thomas T Tsai
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 5853, USA
    N Engl J Med 357:349-59. 2007
    ..Patency or thrombosis of the false lumen in type B acute aortic dissection has been found to predict outcomes. The prognostic implications of partial thrombosis of the false lumen have not yet been elucidated...
  58. ncbi Mortality in women with turner syndrome in Great Britain: a national cohort study
    Minouk J Schoemaker
    Section of Epidemiology, Sir Richard Doll Building, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    J Clin Endocrinol Metab 93:4735-42. 2008
    ..Turner syndrome is characterized by complete or partial X chromosome monosomy. It is associated with substantial morbidity, but mortality risks and causes of death are not well described...
  59. ncbi Manufacturing and placing a bespoke support for the Marfan aortic root: description of the method and technical results and status at one year for the first ten patients
    John Pepper
    Royal Brompton Hospital, London, UK
    Interact Cardiovasc Thorac Surg 10:360-5. 2010
    ..The primary objective of this surgery was achieved in each case, reinforcing the ascending aorta whilst leaving the native aortic valve intact and conserving the blood/endothelium interface...
  60. ncbi Surgical repair of sinus of Valsalva aneurysm in Asian patients
    Zheng jun Wang
    Department of Cardiac Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China
    Ann Thorac Surg 84:156-60. 2007
    ..This study was designed to investigate the difference between Asian and Western patients...
  61. ncbi Identification of a chromosome 11q23.2-q24 locus for familial aortic aneurysm disease, a genetically heterogeneous disorder
    C J Vaughan
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, NY 10021, USA
    Circulation 103:2469-75. 2001
    Aortic aneurysms cause significant mortality, and >20% relate to hereditary disorders. Familial aortic aneurysm (FAA) has been described in such conditions as the Marfan and Ehlers-Danlos type IV syndromes, due to defects in the ..
  62. ncbi Chronobiology of rupture and dissection of aortic aneurysms
    R Manfredini
    Department of Clinical and Experimental Medicine and Center for Vascular Diseases, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Italy
    J Vasc Surg 40:382-8. 2004
    ..One of the most life-threatening cardiovascular emergencies, aortic aneurysm rupture or dissection, also demonstrates periodicity, characterized by a similar temporal distribution, which ..
  63. ncbi Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice
    P J Kuhlencordt
    Cardiovascular Research Center, Cardiology Division, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Circulation 104:448-54. 2001
    ..To test whether deficiency in endothelial nitric oxide synthase (eNOS) affects atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-double knockout (DKO) and apoE-knockout (KO) control animals...
  64. ncbi Acute aortic dissection type A
    T Kruger
    Department of Cardiothoracic and Vascular Surgery, University Hospital Tubingen, Tubingen, Germany
    Br J Surg 99:1331-44. 2012
    ..The purpose of this review was to clarify important clinical issues of AADA management, with a focus on diagnostic and therapeutic challenges...
  65. ncbi Totally percutaneous aortic aneurysm repair: experience and prudence
    Benjamin Ware Starnes
    Department of Surgery, Madigan Army Medical Center, Tacoma, WA 98431 1100, USA
    J Vasc Surg 43:270-6. 2006
    Totally percutaneous aortic aneurysm repair has been shown to be technically feasible, with low morbidity. Complications from percutaneous arterial closure are not insignificant, however, and can be fatal...
  66. ncbi Acute aortic dissection in China
    Yang Li
    Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Am J Cardiol 110:1056-61. 2012
    ..In conclusion, our study has provided insight into the current profiles and outcomes of AAD in China. This knowledge might be useful for clinicians when diagnosing and treating these patients...
  67. ncbi Early and late outcomes of acute type A aortic dissection: analysis of risk factors in 487 consecutive patients
    Bruno Chiappini
    Department of Cardiovascular Surgery, Policlinico S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Eur Heart J 26:180-6. 2005
    ..The purpose of this retrospective study was to assess the risk factors for the early and late outcome of the surgical treatment of acute type A aortic dissection, in terms of mortality and morbidity...
  68. pmc Biomechanical characterization of ascending aortic aneurysm with concomitant bicuspid aortic valve and bovine aortic arch
    T Pham
    Tissue Mechanics Laboratory, Biomedical Engineering Program and Mechanical Engineering Department, 207 Bronwell Building, University of Connecticut, Storrs, CT 06269 3139, USA
    Acta Biomater 9:7927-36. 2013
    ..valve (BAV) or bovine aortic arch (BAA) are more likely than the general population to develop ascending aortic aneurysm (AsAA)...
  69. ncbi Role of age in acute type A aortic dissection outcome: report from the International Registry of Acute Aortic Dissection (IRAD)
    Santi Trimarchi
    Policlinico San Donato IRCCS, San Donato Milanese, Italy
    J Thorac Cardiovasc Surg 140:784-9. 2010
    ..However, because of an increased risk of cardiac surgery in an elderly population, it is important to define when, if at all, the risks of aortic repair outweigh the risk of death from unoperated type A aortic dissection...
  70. ncbi Aortic arch reconstruction by transluminally placed endovascular branched stent graft
    K Inoue
    Department of Cardiovascular Surgery, Takeda Hospital, Kyoto, Japan
    Circulation 100:II316-21. 1999
    ..However, its application has been limited to descending thoracic aortic aneurysms distal to the aortic arch. We report our initial clinical experience of endovascular branched stent graft repair for aortic arch aneurysms...
  71. pmc Open triple-branched stent graft placement for the surgical treatment of acute aortic arch dissection
    Xiaoning Sun
    Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China
    J Cardiothorac Surg 7:130. 2012
    ..The primary experience of open triple-branched stent graft placement for acute aortic arch dissection was reported...
  72. ncbi Ascending aorta cannulation in acute type A aortic dissection
    Yoshito Inoue
    Department of Cardiovascular Surgery, Saiseikai Utsunomiya Hospital, 911 1 Takebayashi, Utsunomiya, Tochigi 321 0974, Japan
    Eur J Cardiothorac Surg 31:976-9; discussion 979-81. 2007
    ..Thus, we evaluated the efficacy of use of the dissected ascending aorta as an alternative arterial inflow...
  73. ncbi Ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve: involvement and clinical relevance of smooth muscle cell apoptosis and expression of cell death-initiating proteins
    Franz Xaver Schmid
    Department of Cardiothoracic and Vascular Surgery, University of Regensburg, Regensburg, Germany
    Eur J Cardiothorac Surg 23:537-43. 2003
    ....
  74. ncbi Aneurysms of the ascending aorta and arch: the role of imaging in diagnosis and surgical management
    Crystal R Bonnichsen
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Mayo Foundation, 200 1st Street SW, Rochester, MN 55905, USA
    Expert Rev Cardiovasc Ther 9:45-61. 2011
    ....
  75. ncbi Reoperation after surgical correction of acute type A aortic dissection: risk factor analysis
    Giovanni Concistrè
    Department of Cardiac Surgery and Heart Transplantation, San Camillo Hospital, Rome, Italy
    Ann Thorac Surg 93:450-5. 2012
    ..We conducted a study to evaluate risk factors and define the incidence and locations of reoperations after surgical correction of acute type A aortic dissection (AAD)...
  76. ncbi Valve-sparing aortic root repair with patch technique
    Paul P Urbanski
    Department of Cardiovascular Surgery, Cardiovascular Center Bad Neustadt, Bad Neustadt, Germany
    Ann Thorac Surg 80:839-43. 2005
    ..In the valve-sparing aortic root repair technique presented, each pathologic sinus is replaced with a teardrop-shaped patch. In this study, the clinical and echocardiographic results after the first 20 procedures are evaluated...
  77. ncbi Ascending aortic aneurysm in a patient with mixed gonadal dysgenesis
    N Bakoto
    Endocrinologie, CHU Saint Pierre, Exposition Universelle, Bruxelles, Belgium
    Ann Endocrinol (Paris) 72:45-7. 2011
    ..This case report, and the few others, which have been previously reported in the literature, emphasizes the importance of cardiologic and endocrine follow-up in male carriers of 45,X/46,XY mosaicism...
  78. ncbi Clinical outcome after repair of acute type A dissection in patients over 70 years-old
    Thierry Caus
    Cardiac Surgery Department, Timone University Hospital, Bd Jean Moulin, 13385 Marseilles, France
    Eur J Cardiothorac Surg 22:211-7. 2002
    ..Whether any patient of an advanced aged suffering from acute dissection of the proximal aorta should be referred for surgery deserves specific clinical studies...
  79. ncbi Metastatic signet ring cell gastric carcinoma presenting as an infrarenal aortic aneurysm
    Thomas Menzel
    Department of Medicine, University of Wuerzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Gastric Cancer 8:47-9. 2005
    ..We report an unusual case of a signet ring cell gastric carcinoma, initially presenting as an infrarenal aortic aneurysm. Following resection of the aneurysm, the spread of lymphangiosis carcinomatosa into the aortic wall and ..
  80. ncbi Surgical management and long-term outcomes for acute ascending aortic dissection
    Louis Mathieu Stevens
    Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Thorac Cardiovasc Surg 138:1349-57.e1. 2009
    ....
  81. ncbi Surgery for acute type A dissection with the tear in the descending aorta using a stented elephant trunk procedure
    Lizhong Sun
    Department of Cardiovascular Surgery, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Ann Thorac Surg 87:1177-80. 2009
    ....
  82. ncbi Structural and biomolecular changes in aorta and pulmonary trunk of patients with aortic aneurysm and valve disease: implications for the Ross procedure
    Franz Xaver Schmid
    Department of Cardiothoracic and Vascular Surgery, University Hospital Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Eur J Cardiothorac Surg 25:748-53. 2004
    ....
  83. ncbi Aortic valve reimplantation in ascending aortic aneurysm: risk factors for early valve failure
    Klaus Pethig
    Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Germany
    Ann Thorac Surg 73:29-33. 2002
    ..Information about long-term follow-up is limited, and possible predictors for failure of reconstruction have not been evaluated so far...
  84. ncbi Vascular smooth muscle cell remodelling in elastase-induced aortic aneurysm
    Lei Jiao
    The First Affiliated Hospital of Suzhou University Neurosurgery, Suzhou University, City of SuZhou, Jiangsu, P R China
    Acta Cardiol 65:499-506. 2010
    ..OBJECTIVE; ; The objective of this study was to identify developmental changes in vascular smooth muscle cells (VSMC) during aneurysm formation using an elastase-induced rabbit carotid artery aneurysm model...
  85. ncbi Severe tracheal compression due to cervical aortic arch aneurysm
    Yosuke Takahashi
    Department of Cardiovascular Surgery, Fukui Cardiovascular Center, Fukui, Japan
    J Card Surg 26:400-2. 2011
    ..Total arch replacement was performed and the tracheal compression was relieved. The postoperative course was uneventful and the tracheal stenosis was gradually decreased by 12 months after surgery. ..
  86. pmc Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics at the Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Mol Genet 19:4790-8. 2010
    ..Taken together, our findings shed new light on the pathogenesis of osteopenia in MFS, in addition to arguing for a multifaceted treatment strategy in this congenital disorder of the connective tissue...
  87. ncbi Identification of a novel TGFBR2 gene mutation in a Korean patient with Loeys-Dietz aortic aneurysm syndrome; no mutation in TGFBR2 gene in 30 patients with classic Marfan's syndrome
    C S Ki
    Clin Genet 68:561-3. 2005
  88. ncbi Multilevel somatosensory evoked potentials and cerebrospinal proteins: indicators of spinal cord injury in thoracoabdominal aortic aneurysm surgery
    Anders Winnerkvist
    Department of Cardiothoracic Surgery and Anaesthesiology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Cardiothorac Surg 31:637-42. 2007
    ....
  89. ncbi Pregnancy-related aortic aneurysm and dissection in patients with Marfan's syndrome: medical and surgical management during pregnancy and after delivery
    Mile Vranes
    Cardiac Surgery Clinic, Clinical Center of Serbia, Belgrade, Serbia
    Medicina (Kaunas) 47:604-6. 2011
    In the current article, 3 cases of aortic aneurysm and dissection in pregnant patients with Marfan's syndrome are reported...
  90. ncbi Quadricuspid aortic valve with ascending aortic aneurysm: report of a case and discussion of embryological mechanisms
    Robert R Attaran
    Sarver Heart Center, University of Arizona, Tucson, AZ 85724, USA
    Cardiovasc Pathol 18:49-52. 2009
    ..A QAV with an associated ascending aortic aneurysm is extremely rare, and these conditions might have a shared embryonic etiology...
  91. ncbi Reevaluation of direct true lumen cannulation in surgery for acute type A aortic dissection
    Lars O Conzelmann
    Department of Cardiothoracic and Vascular Surgery, Johannes Gutenberg University Mainz, Germany
    Ann Thorac Surg 87:1182-6. 2009
    ..The optimal mode of arterial cannulation in acute type A aortic dissection is controversial. We retrospectively investigated our experience with direct true lumen cannulation as an alternative to standard cannulation procedures...
  92. ncbi Early and late surgical outcomes of acute type A aortic dissection in patients aged 75 years and older
    K Kawahito
    Department of Cardiovascular Surgery, Omiya Medical Center, Jichi Medical School, Saitama, Japan
    Ann Thorac Surg 70:1455-9. 2000
    ..In this study, we reviewed early and late surgical outcomes of acute type A dissection (operation within 48 hours after onset) in patients aged 75 years and older...
  93. ncbi Reoperation for ascending aortic aneurysm, coronary ostial aneurysm and patent Cabrol trick after bentall operation for aortitis syndrome
    Motomi Shiono
    Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
    Circ J 69:861-4. 2005
    ..December 1995 for annuloaortic ectasia associated with ulcerative colitis required reoperation for ascending aortic aneurysm, coronary ostial aneurysm, and patent Cabrol trick...
  94. ncbi Importance of refractory pain and hypertension in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD)
    Santi Trimarchi
    Policlinico San Donato IRCCS, Cardiovascular Center E Malan, University of Milano, Via Morandi 30, 20097 San Donato Milanese, Italy
    Circulation 122:1283-9. 2010
    ..The International Registry of Acute Aortic Dissection (IRAD) was used to investigate the impact of refractory pain and/or refractory hypertension on the outcomes of acute type B aortic dissection...
  95. ncbi Biomarker-assisted diagnosis of acute aortic dissection: how far we have come and what to expect
    Toru Suzuki
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Curr Opin Cardiol 25:541-5. 2010
    ..Early and immediate diagnosis is important for initiation of treatment and improved survival. Despite recent advances in imaging methods to diagnose the disease, biochemical methods are not available...
  96. ncbi Therapy insight: aortic aneurysm and dissection in Marfan's syndrome
    Francesco Ramirez
    Laboratory of Genetics and Organogenesis, Hospital for Special Surgery at the Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Nat Clin Pract Cardiovasc Med 1:31-6. 2004
    ..Dissecting aortic aneurysm in this disorder is accounted for by mutations in fibrillin-1, the major component of the microfibrils ..
  97. ncbi One-stage repair of aortic coarctation and ascending aortic aneurysm by extra-anatomic graft
    Guido Gelpi
    Cardiovascular Division, L Sacco Hospital, Milan, Italy
    J Cardiovasc Med (Hagerstown) 10:554-6. 2009
    ..In our opinion, ascending-to-descending extra-anatomic graft is a good solution to treat these complicated cases...
  98. ncbi Response of serum proteome in patients undergoing infrarenal aortic aneurysm repair
    Pietro Amedeo Modesti
    Department of Critical Care Medicine and Don C Gnocchi Foundation, University of Florence, Viale Morgagni 85, Florence, Italy
    Anesthesiology 111:844-54. 2009
    Postoperative organ dysfunction in conventional surgery for abdominal aortic aneurysm (AAA) is associated with a complex inflammatory reaction, with activation of coagulation and fibrinolysis...
  99. ncbi Massive aortic aneurysm and dissection in repaired tetralogy of Fallot; diagnosis by cardiovascular magnetic resonance imaging
    Vikas K Rathi
    Int J Cardiol 101:169-70. 2005
  100. ncbi Resistant hypertension in patients with chronic aortic dissection
    H Eggebrecht
    Department of Cardiology, West German Heart Center Essen, University of Duisburg Essen, Essen, Germany
    J Hum Hypertens 19:227-31. 2005
    ..However, in a significant proportion of patients (40%), who appear to be younger and more obese, medical therapy fails to achieve effective BP control despite use of a multiple drug regimen...
  101. ncbi Hypogastric artery preservation during endovascular aortic aneurysm repair: is it important?
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Vasc Surg 22:193-200. 2009
    ..Lastly, treatment strategies to preserve the hypogastric artery thereby obviating the need for hypogastric artery embolization are discussed...

Research Grants72

  1. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..using the thrombin non-cleavable OPN R153A knockin mice in inflammation, hemopoietic stem cell mobilization, aortic aneurysm, and cancer models...
  2. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
    ..The clinical relevance of this proposal is underscored by the increasing incidence of AAAs among the VA population and the limited treatment options that are currently available. ..
  3. Tissue Factor &Clot Formation In Abdominal Aortic Aneurysm
    ALBERT PHILLIP OWENS; Fiscal Year: 2013
    ..focused on understanding the initiation and progression of cardiovascular disease with a focus on abdominal aortic aneurysm. Like every other scientist, I hope to one day find an effective treatment to alleviate the suffering of ..
  4. Angiotensin II uncoupling of eNOS in hypertension
    HUA LINDA CAI; Fiscal Year: 2013
    ..of the proposed studies is to investigate an innovative role of eNOS uncoupling in the formation of abdominal aortic aneurysm (AAA)...
  5. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..Utilizing Plg deficient (Plg-/-) mice in peritonitis and abdominal aortic aneurysm (AAA) models, our studies provide in vivo evidence that Plg/plasmin is required for macrophage recruitment ..
  6. HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
    Hugh Rosen; Fiscal Year: 2010
    ..these inhibitors have the potential to provide novel therapeutic approaches to inhibit hypertension, aortic aneurysm, myocardial infarction, pulmonary fibrosis, arthritis, Alzheimer's disease, stroke, cancer, and ..
  7. Atomic Force Microscopic Studies of Dissecting Aneurysm
    Paul J Boor; Fiscal Year: 2013
    ..rats (dams) during their third trimester, results in a vascular lesion in newborn pups known as dissecting aortic aneurysm, or DAA. DAA is the sudden tearing, or splitting of the layers of the muscular wall of the thoracic aorta...
  8. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..studies will provide novel insights regarding a previously unappreciated transcriptional pathway governing aortic aneurysm development...
  9. Smooth Muscle Differentiation and Maturation
    Shiyou Chen; Fiscal Year: 2013
    ..of several prominent cardiovascular disease states including atherosclerosis, congenital heart diseases, aortic aneurysm, hypertension, and restenosis...
  10. Syndecan-1 in Aortic Aneurysm Formation
    Elliot Chaikof; Fiscal Year: 2012
    ..of the heparan sulfate proteoglycan syndecan-1 may provide an important mechanism that inhibits abdominal aortic aneurysm (AAA) formation by limiting proteolytic or inflammatory activity and by promoting local reparative responses...
  11. Microfibril Fragments: Biomarkers of Aortic Disease
    Lynn Y Sakai; Fiscal Year: 2010
    ..this approach can identify novel biomarkers associated with Marfan syndrome (fibrillin-2 fragment 72-143) and aortic aneurysm (fibrillin-2 fragment 48-60) and can reveal signature biomarker profiles of aortic aneurysm (reduced ..
  12. Transforming Growth Factor-beta Signaling Pathways in Thoracic Aortic Aneurysms
    Jeffrey A Jones; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thoracic aortic aneurysm (TAA) disease is a potentially devastating disease process which often causes death by rupture in the absence of symptoms...
  13. Molecular Biology of Marfan Syndrome
    Harry C Dietz; Fiscal Year: 2013
    ..Many manifestations of MFS, including aortic aneurysm and tear, are driven by excessive TGFbeta signaling, particularly the noncanonical ERK cascade, and can be ..
  14. Regulation of AT1R-signaling and pathology in vessels through microRNA
    Sadashiva S Karnik; Fiscal Year: 2013
    ..There is potential relevance for this knowledge base in understanding normal functioning aorta, vasculature in brain, kidney and heart, as well as the pathology of heart failure, atherosclerosis and aortic aneurysm.
  15. Loss of Matrix Regulation and Aortic Aneurysm Development in vivo
    Hiromi Yanagisawa; Fiscal Year: 2013
    ..Understanding the dynamic relationship between ECM and SMCs will provide a solid foundation for pharmacological interventions and could offer new therapeutic opportunities to various congenital aortic aneurysms. . ..
  16. Bifunctional Nitric Oxide Donor Refractory to Nitrate Tolerance
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..a frequent and life-threatening condition that increases the risk of cardiovascular events such as stroke and aortic aneurysm. We are developing a novel drug that targets the basic mechanisms of refractory hypertension and has been ..
  17. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Although thoracic aortic aneurysm and dissection (TAAD) are not as common as some forms of vascular diseases, e.g. coronary artery disease, it is a clinically insidious disease with high fatality...
  18. Age-Dependent Mechanisms in Thoracic Aortic Aneurysms
    John S Ikonomidis; Fiscal Year: 2013
    ..Because thoracic aortic aneurysm (TAAs) occur most frequently in persons 60-70 years of age, it follows that over the next two decades the ..
  19. CCN3 and aortic aneurysm
    Zhiyong Lin; Fiscal Year: 2013
    ..In Aim 1, we will fully characterize the role of CCN3 in aortic aneurysm formation...
  20. Gender Specific Evolution of Abdominal Aortic Aneurysm Composition and Properties
    Jay D Humphrey; Fiscal Year: 2013
    Gender Specific Evolution of Aortic Aneurysm Composition and Properties PROJECT SUMMARY Aortic aneurysms are focal dilatations of the arterial wall that are increasingly responsible for significant mortality and morbidity...
  21. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..An abdominal aortic aneurysm (AAA) is a condition in which the aorta, the main blood vessel in the abdomen, expands like a balloon...
  22. Molecular Imaging of Protease Activation in Aneurysm
    Mehran M Sadeghi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vascular diseases, including aortic aneurysm, are major causes of morbidity and mortality in the US...
  23. Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty; Fiscal Year: 2010
    ..These projects will be supported by Cores of: A. Administration. B. Human studies. C. Mouse maintenance. D. Quantitative pathology. ..
  24. ROS Mechanisms in BAV Aortopathy
    THOMAS GILLETTE GLEASON; Fiscal Year: 2013
    ..composition of expertise and has devised a novel approach to prove that ROS accumulation in BAV-ascending aortic aneurysm (TAA) specimens leads to de-differentiation of SMCs, abnormal extracellular matrix (ECM) composition and ..
  25. The Effects of KLF4 in experimental aortic aneurysm formation
    Gorav Ailawadi; Fiscal Year: 2013
    ..Aim 2 will determine if epigenetic mechanisms contribute to the effects of KLF4 on aortic aneurysm formation...
  26. Identifying Epidemiological Risk Factors for Abdominal Aortic Aneurysm
    Weihong Tang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is a common disease in the elderly and an important public health problem...
  27. The role of CDKN2B in AAA disease
    NICHOLAS JAMES LEEPER; Fiscal Year: 2013
    ..seek to elucidate the relationship between the intergenic risk-associated region of 9p21 and abdominal aortic aneurysm (AAA) disease...
  28. 3D Ultrasound Guidance of Interventional Devices
    Stephen William Smith; Fiscal Year: 2012
    ..breakthroughs in the development and application of interventional medical devices including vascular stents, aortic aneurysm stent grafts, vena cava filters, vascular occluders, cardiac occluders, prosthetic cardiac valves, and ..
  29. Gender Differences in Experimental Aortic Aneurysms
    GILBERT RIVERS UPCHURCH; Fiscal Year: 2012
    ..Overall hypothesis: Gender- related differences in aortic aneurysm formation are mediated by the hormonal (androgen: estrogen ratio) regulation of leukocyte trafficking into ..
  30. Identification and study of the vascular disease gene at 9p21.3
    Thomas Quertermous; Fiscal Year: 2013
    ..In addition to CHD, variants at C9CAR have been associated with other vascular diseases, including abdominal aortic aneurysm, stroke, and peripheral vascular disease...
  31. DNA Variants and AAA Disease
    Philip S Tsao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) disease is a common, morbid and highly lethal disease. Prior studies indicate a strong genetic component to the disease involving multiple loci...
  32. Molecular mechanisms in Abdominal Aortic Aneuysm
    Bo Liu; Fiscal Year: 2013
    Abdominal aortic aneurysm is a common age related and potentially lethal disease that develops as the result of a complex interplay among chronic inflammation, extracelluar matrix (ECM) degradation, and impaired ECM biosynthesis ..
  33. Aortic Wall Behavior as a Predictor of Aortic Aneurysm Growth
    Rabih A Chaer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) rupture is the 13th leading cause of death among individuals aged 65-85.1 Small AAA growth and rupture are highly variable between patients and over time...
  34. Roles of SMC TGF-beta Signaling in Aortic Health and Aneurysm Formation
    David A Dichek; Fiscal Year: 2013
    ..Aim 3 will test the hypothesis that loss of SMC TGF-[unreadable] signaling in a mouse model of acquired aortic aneurysm formation (chronic angiotensin II infusion) will accelerate SMC damage and aneurysm growth...
  35. AMPK as a redox sensor and modulator
    Ming Hui Zou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAAs) is the most common form of aortic aneurysm and ruptured AAAs cause at least 15,000 deaths each year in the US...
  36. Quantitative Analysis of Relationships Among Hemodynamics, Thrombus, and Abdomina
    Seungik Baek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is the focal enlargement of the aorta in the abdomen and its rupture is the 3rd leading cause of sudden death in men older than 65 years in the US...
  37. Correlation of MMP activity with anatomic changes in the ruptured AAA wall
    SEAN JASON ENGLISH; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is a lethal disease, with significant public health ramifications as the population ages. AAA rupture is associated with a uniformly high mortality rate (80%)...
  38. Aortic Aneurysm Formation: Mechanisms of Oxidative Stress-Induced MMP Expression
    MATTHEW JEREMIAH EAGLETON; Fiscal Year: 2012
    ..the mechanisms by which oxidative stress regulates matrix metalloproteinase (MMP) expression during aortic aneurysm formation...
  39. Development Underpinnings of Acquired Aortic Aneurysm in Marfan Syndrome
    Mark E Lindsay; Fiscal Year: 2013
    ..beta (TGF-2) axis in human vascular disease has revolutionized the pathogenetic understanding of thoracic aortic aneurysm (TAA)...
  40. Quality of Life in People with Abdominal Aortic Aneurysms
    BRIAN WILLIAM NOLAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Each year over 200,000 Americans are found to have an abdominal aortic aneurysm (AAA). Through a combination of factors, including increased screening, the number of diagnoses is likely to rise...
  41. The role of p16INK4a in mammalian aging
    Norman E Sharpless; Fiscal Year: 2013
    ..as frailty, type 2 diabetes and atherosclerotic disease (myocardial infarction, ischemic stroke and abdominal aortic aneurysm)...
  42. Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT )
    Michael L Terrin; Fiscal Year: 2013
    ..Without medical therapy, ultrasound screening is considered cost-effective in selected patients only. Effective medical therapy would make early detection even more acceptable by providing an alternative to invasive repair of AAA. ..
  43. Prostanoid-dependent abdominal aortic aneurysm formation
    Charles Loftin; Fiscal Year: 2010
    ..Therefore, we will use an animal model of this disease to determine the mechanisms by which this disease occurs in humans. These studies are important as they will help identify non-surgical treatments for this disease in humans. ..
  44. Mouse Models for Elastic Fiber Diseases
    MON LI H CHU; Fiscal Year: 2010
    ..missense mutations in fibulin-4 have been identified in human patients with clinical manifestations of aortic aneurysm, pulmonary artery stenosis, tortuous arteries, emphysema, congenital bone fractures, joint laxity and cutis ..
  45. Cell-Mediated and Autoimmune Responses in Abdominal Aortic Aneurysm (AAA)
    Bernard Timothy Baxter; Fiscal Year: 2013
    ..can occur in any location of the aorta, but most are found in the distal abdominal segment, hence, abdominal aortic aneurysm or AAA. AAA is more common in men, but rupture risk for small aneurysms is threefold higher in women...
  46. Genetic Etiology of Bicuspid Aortic Valve Disease
    Simon C Body; Fiscal Year: 2013
    ..biology and modifiers of disease progression for BAV to aortic valve stenosis and incompetence, and thoracic aortic aneurysm/dissection...
  47. Mechanisms and Significance of Angiogenesis in AAA Disease
    Ronald L Dalman; Fiscal Year: 2013
    ..our fundamental hypothesis that VEGF-A-mediated mural angiogenesis is a critical and rate-limiting factor in aortic aneurysm pathogenesis, and that manipulation of VEGF signaling will modulate progression and regression of ..
  48. Ischemic Spasticity: Modulation by GAD65 Gene Delivery
    Martin Marsala; Fiscal Year: 2010
    ..Similar development of spasticity and rigidity in patients undergoing thoracoabdominal aortic aneurysm repair or after traumatic spinal injury had been described...
  49. Noninvasive qualitative and quantitative assessment of vascular disease in vivo
    Elisa E Konofagou; Fiscal Year: 2013
    ..of focal vascular disease and given the expertise of the team of investigators, the disease of abdominal aortic aneurysm, the most common aneurysm type and an often silent and deadly disease, will first be considered followed by ..
  50. Resistance to Aortic Endograft Migration: Comparative Effectiveness of FDA Approv
    Christopher K Zarins; Fiscal Year: 2010
    ..Currently, there are 5 FDA approved abdominal aortic aneurysm endografts: Medtronic AneuRx, Gore Excluder, Cook Zenith, Endologix Powerlink, and Medtronic Talent...
  51. Accounting for confounding bias and heterogeneity in comparative effectiveness
    ALISTAIR JAMES O apos MALLEY; Fiscal Year: 2010
    ..comorbidity, reformulations of existing psychiatric drug treatments, and the surgical repair for abdominal aortic aneurysm (AAA)...
  52. AAA Disease: Mechanism, Stratification and Treatment
    Ronald L Dalman; Fiscal Year: 2010
    Abdominal aortic aneurysm (AAA) is a common, morbid, and frequently lethal disease of older Americans...
  53. Hemodynamics and AAA disease: Uncovering the Hidden Connections
    Shawn C Shadden; Fiscal Year: 2012
    ..that blood flow mechanics (hemodynamics) play a leading role in the development and progression of abdominal aortic aneurysm (AAA) disease...
  54. Siemens S2000 Cardiovascular Ultrasound System
    James H Stein; Fiscal Year: 2013
    ..consequences and treatment of CV disease risk factors and conditions, including atherosclerosis, aortic aneurysm, tobacco use, sleep-disordered breathing, hypertension, pulmonary hypertension, human immunodeficiency virus, ..
  55. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..An abdominal aortic aneurysm (AAA) is a condition in which the aorta, the main blood vessel in the abdomen, expands like a balloon...
  56. Long Term Outcomes of Open Versus Endovascular AAA Repair
    Marc Schermerhorn; Fiscal Year: 2013
    Project Summary: Ruptured abdominal aortic aneurysm (AAA) is the 10th leading cause of death in men over age 55 in the US with mortality of ruptured AAA exceeding 80%...
  57. Growth and Remodeling Model of Abdominal Aortic Aneurysm: Toward Clinical Applica
    Seungik Baek; Fiscal Year: 2013
    ....
  58. Geisinger eGenonic Medicine (GeM) Program
    Marc S Williams; Fiscal Year: 2013
    ..or altered treatment response;proposed new ePhenotypes are extreme obesity and related conditions, abdominal aortic aneurysm, and weight gain induced by anti-psychotic drugs;2) develop and test approaches to provide clinically ..
  59. Patient-Specific Modeling for Analysis of Aortic Aneurysms
    CAITLIN MARIE MARTIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Currently, aortic aneurysm rupture potential is primarily evaluated based on the aneurysm diameter;however, the overall aneurysm diameter has been shown to be an unreliable predictor of aneurysm ..
  60. Bioengineering Studies of Abdominal Aortic Aneurysm Fluid and Wall Dynamics
    ENDER FINOL; Fiscal Year: 2009
    ..This methodology is expected to greatly enhance the presurgical planning capabilities of vascular surgeries and endovascular therapies in the future management of cardiovascular diseases. ..
  61. Measuring the Efficacy of Endovascular Treatment of AAA
    Peter Faries; Fiscal Year: 2007
    ..The study will use an experimental model of abdominal aortic aneurysm with an implanted pressure transducer, developed in the principal investigator's laboratory...
  62. Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
    ERIC JEFFREY TOPOL; Fiscal Year: 2013
    ..A genomic variant associated with CAD, myocardial infarction (Ml), abdominal aortic aneurysm, and intracranial aneurysm is found in a stretch of chr9p21 devoid of known genes...
  63. THE ROLE OF WALL STRESS DISTRIBUTION IN ABDOMINAL AORTIC
    Mark Fillinger; Fiscal Year: 2001
    In the clinical management of patients with an abdominal aortic aneurysm (AAA), physicians have long sought the ability to reliably identify patients with a high risk of rupture and those who are relatively safe from rupture...
  64. Vascular Surgery Research Training
    Edith Tzeng; Fiscal Year: 2013
    ..autologous conduits, tissue ischemia induced angiogenesis and wound healing, computational analysis of aortic aneurysm progress and rupture, cardiovascular imaging, epidemiology of cardiovascular disease, and ..
  65. BIOMECHANICAL EVALUATION OF ABDOMINAL AORTIC ANEURYSM
    DAVID ALAN VORP; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is a focal enlargement of the infrarenal aorta. If left untreated, AAA will gradually expand until rupture, an event that carries a mortality rate of 90%...
  66. Real-Time VLS Detection of Colon Ischemia in AAA Repair
    David Benaron; Fiscal Year: 2004
    This Phase I SBIR proposal addresses the need to detect colon ischemia associated with the repair of Abdominal Aortic Aneurysm (AAA). AAA can be found in 5% of the adult population over 50...
  67. GENETIC BASIS OF ABDOMINAL AORTIC ANEURYSM
    Robert Ferrell; Fiscal Year: 2000
    DESCRIPTION: (Adapted from Investigator's Abstract) Abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta which can, if undetected, lead to rupture...
  68. Integrated Microfluidic Platelet Activation Assay
    Lawrence Leung; Fiscal Year: 2009
    ..hemostatic indicator during procedures that particularly stress the circulatory system, including abdominal aortic aneurysm repair and coronary bypass surgery...
  69. A STRUCTURED CRITERIA REVIEW PROCESS FOR FOUR SURGICAL P
    J Schwartz; Fiscal Year: 1991
    ..is involved in developing appropriateness criteria for coronary artery bypass graft surgery, abdominal aortic aneurysm resection, cataract extraction and carotid endarterectomy...
  70. FAMILIAL AORTIC ANEURYSM: A MOLECULAR GENETIC ANALYSIS
    Craig Basson; Fiscal Year: 2005
    DESCRIPTION (the applicant's description verbatim): Aortic aneurysm is an often fatal cardiovascular disease. Many aortic aneurysms are clinically silent until they rupture with devastating clinical consequences...
  71. Doxycycline Treatment of Abdominal Aortic Aneurysm: Planning
    Michael Terrin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  72. AUTOIMMUNE AORTIC ANTIGENS IN ABDOMINAL AORTIC ANEURYSMS
    MARTIN TILSON; Fiscal Year: 2002
    ..The array of genetic factors that participate in the formation and evolution of abdominal aortic aneurysm (AAA) remains to be established. This application is a component of a Collaborative R01 in which Drs. Craig T...