aneurysm

Summary

Summary: A sac formed by the dilatation of the wall of an artery, a vein, or the heart.

Top Publications

  1. doi MicroRNAs and aneurysm formation
    Reinier A Boon
    Institute of Cardiovascular Regeneration, Center for Molecular Medicine, Goethe University, 60596 Frankfurt, Germany
    Trends Cardiovasc Med 21:172-7. 2011
  2. ncbi Renal angiomyolipoma: relationships between tumor size, aneurysm formation, and rupture
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 225:78-82. 2002
  3. doi Irradiation with 780 nm diode laser attenuates inflammatory cytokines but upregulates nitric oxide in lipopolysaccharide-stimulated macrophages: implications for the prevention of aneurysm progression
    Lilach Gavish
    Department of Anatomy and Cell Biology, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
    Lasers Surg Med 40:371-8. 2008
  4. ncbi Histological postmortem study of an internal carotid artery aneurysm treated with the Neuroform stent
    Demetrius Lopes
    Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA
    Neurosurgery 56:E416; discussion E416. 2005
  5. doi Endovascular stent-graft placement and coil embolization for an anomalous splenic artery aneurysm
    Jianjun Jiang
    Department of Vascular Surgery, Qilu Hospital of Shandong University, Ji Nan, China
    J Vasc Surg 54:208-11. 2011
  6. ncbi Aberrant subclavian artery and Kommerell aneurysm: surgical treatment with a standard approach
    Nicholas T Kouchoukos
    Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical Center, St Louis, Missouri, USA
    J Thorac Cardiovasc Surg 133:888-92. 2007
  7. ncbi A minimally invasive approach to the treatment of aberrant splenic artery aneurysms: a report of two cases
    Tara Marie Mastracci
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Vasc Surg 41:1053-7. 2005
  8. ncbi Splenic artery aneurysm of the anomalous splenomesenteric trunk: successful treatment by transcatheter embolization using detachable coils
    Motohiro Sato
    Department of Radiology, Ibaraki Prefectural Central Hospital, Tomobe machi, Nishiibaraki Gun, Ibaraki, Japan
    Cardiovasc Intervent Radiol 29:432-4. 2006
  9. ncbi Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis
    Matt Thompson
    St George s Vascular Institute and Academic Department of Vascular Surgery, St George s, University of London, UK
    Ann N Y Acad Sci 1085:170-4. 2006
  10. ncbi Embolization of a giant pulmonary artery aneurysm from Behcet disease with use of cyanoacrylate and the "bubble technique"
    Barbaros E Cil
    Department of Radiology, Hacettepe University School of Medicine, Sihhiye 06100, Ankara, Turkey
    J Vasc Interv Radiol 16:1545-9. 2005

Detail Information

Publications292 found, 100 shown here

  1. doi MicroRNAs and aneurysm formation
    Reinier A Boon
    Institute of Cardiovascular Regeneration, Center for Molecular Medicine, Goethe University, 60596 Frankfurt, Germany
    Trends Cardiovasc Med 21:172-7. 2011
    ..miRs) have emerged as key regulators of biological processes, and they were recently shown to be involved in aneurysm formation...
  2. ncbi Renal angiomyolipoma: relationships between tumor size, aneurysm formation, and rupture
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 225:78-82. 2002
    To evaluate the relationships between tumor size, aneurysm formation, and spontaneous rupture in renal angiomyolipomas.
  3. doi Irradiation with 780 nm diode laser attenuates inflammatory cytokines but upregulates nitric oxide in lipopolysaccharide-stimulated macrophages: implications for the prevention of aneurysm progression
    Lilach Gavish
    Department of Anatomy and Cell Biology, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
    Lasers Surg Med 40:371-8. 2008
    ..Inflammation is a major component of arteriosclerotic diseases including aneurysm. Macrophage recruitment and secretion of pro-inflammatory cytokines and the vasodilator, nitric oxide (NO), are ..
  4. ncbi Histological postmortem study of an internal carotid artery aneurysm treated with the Neuroform stent
    Demetrius Lopes
    Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA
    Neurosurgery 56:E416; discussion E416. 2005
    ..We report here the first postmortem histological analysis of a patient with an internal carotid artery aneurysm treated with the Neuroform stent.
  5. doi Endovascular stent-graft placement and coil embolization for an anomalous splenic artery aneurysm
    Jianjun Jiang
    Department of Vascular Surgery, Qilu Hospital of Shandong University, Ji Nan, China
    J Vasc Surg 54:208-11. 2011
    ..Most previous cases were managed by open surgical intervention. We present a case of an anomalous splenic artery aneurysm, which was successfully treated with endovascular stent graft placement and coil embolization...
  6. ncbi Aberrant subclavian artery and Kommerell aneurysm: surgical treatment with a standard approach
    Nicholas T Kouchoukos
    Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical Center, St Louis, Missouri, USA
    J Thorac Cardiovasc Surg 133:888-92. 2007
    ..We report our experience with a standard surgical technique for treatment of aneurysms associated with Kommerell diverticulum and aberrant subclavian artery...
  7. ncbi A minimally invasive approach to the treatment of aberrant splenic artery aneurysms: a report of two cases
    Tara Marie Mastracci
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Vasc Surg 41:1053-7. 2005
    ..of the splenic artery achieved by developing a retropancreatic plane and applying clips immediately distal to the aneurysm. This appears a promising minimally invasive technique to treat this rare condition...
  8. ncbi Splenic artery aneurysm of the anomalous splenomesenteric trunk: successful treatment by transcatheter embolization using detachable coils
    Motohiro Sato
    Department of Radiology, Ibaraki Prefectural Central Hospital, Tomobe machi, Nishiibaraki Gun, Ibaraki, Japan
    Cardiovasc Intervent Radiol 29:432-4. 2006
    ..We report a case of an aneurysm involving the origin of the splenic artery that anomalously arose from the SMA, and which was successfully ..
  9. ncbi Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis
    Matt Thompson
    St George s Vascular Institute and Academic Department of Vascular Surgery, St George s, University of London, UK
    Ann N Y Acad Sci 1085:170-4. 2006
    The pathogenesis of abdominal aortic aneurysm (AAAs) involves progressive cycles of proteolysis and inflammation, the product of proteolysis driving subsequent inflammation. Little is yet known about the initiating events...
  10. ncbi Embolization of a giant pulmonary artery aneurysm from Behcet disease with use of cyanoacrylate and the "bubble technique"
    Barbaros E Cil
    Department of Radiology, Hacettepe University School of Medicine, Sihhiye 06100, Ankara, Turkey
    J Vasc Interv Radiol 16:1545-9. 2005
    Pulmonary artery aneurysm (PAA) is a common manifestation and leading cause of mortality related to Behcet disease. Endovascular treatment is usually required when medical therapy alone fails to control progression...
  11. doi Infliximab therapy for idiopathic retinal vasculitis, aneurysm, and neuroretinitis syndrome
    Rizwan A Cheema
    Dhahran Eye Specialist Hospital, Dhahran, Kingdom of Saudi Arabia
    J Ocul Pharmacol Ther 27:407-10. 2011
    We report our experience in treating 2 patients of idiopathic retinal vasculitis, aneurysm, and neuroretinitis (IRVAN) syndrome with antitumor necrosis factor agent, infliximab, who showed a very favorable response to treatment.
  12. doi The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms
    Hazem Abdul-Hussien
    Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Vasc Surg 51:1479-87. 2010
    There is remarkable controversy over the processes driving abdominal aneurysm growth. The inherent limitations of animal and human studies hamper elucidation of the key inflammatory and proteolytic processes...
  13. ncbi Management of true splenic artery aneurysms. Two case reports and review of the literature
    M Nincheri Kunz
    Section of General Surgery, Department of Critical Medicine and Surgery, University of Florence, Florence, Italy
    Minerva Chir 58:247-56. 2003
    ..We hope in the future instrumentation will likely improve so that this procedure can be done percutaneously by development of prosthetic devices in the 21th century...
  14. ncbi Endovascular interventions on persistent sciatic arteries
    A Gabelmann
    Department of Diagnostic Radiology, University Clinics of Ulm, Germany
    J Endovasc Ther 8:622-8. 2001
    ..To report our experience with interventional procedures used to treat complete and incomplete persistent sciatic arteries (PSA)...
  15. ncbi Aneurysms of the innominate artery: surgical treatment of 27 patients
    E Kieffer
    Department of Vascular Surgery, Pitie Salpetriere University Hospital, Paris France
    J Vasc Surg 34:222-8. 2001
    ..Aneurysms of the innominate artery (AIA) are widely considered to be a rare entity. We describe our experience with AIAs in the last three decades...
  16. ncbi Effects of temporary clipping during aneurysm surgery
    Chris Woertgen
    Department of Neurosurgery, University of Regensburg, Regensburg, Germany
    Neurol Res 30:542-6. 2008
    Intraoperative aneurysm rupture is associated with a high morbidity and mortality. Temporary vessel occlusion is an integral part of aneurysm clipping to avoid intraoperative hemorrhage...
  17. doi Successful cyclophosphamide therapy with complete resolution of pulmonary artery aneurysm in Hughes-Stovin syndrome patient
    Jaejoon Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Clin Rheumatol 27:1455-8. 2008
    ..We report a case of Hughes-Stovin syndrome with complete resolution of pulmonary artery aneurysm after treatment with cyclophosphamide...
  18. ncbi Rare case of multiple pulmonary artery aneurysms with caval thrombosis--Hughes-Stovin syndrome
    Jung Tae Kim
    Department of Cardiovascular and Thoracic Surgery, Kangbuk Samsung Hospital School of Medicine, Sungkyunkwan University, 108 Pyoung Dong Jongno gu, Seoul, Republic of Korea
    Eur J Cardiothorac Surg 31:561-2. 2007
    ..The bilateral lower lobe aneurysms were successfully treated with staged operations. The patient tolerated the procedures relatively well and was followed up by steroid therapy with a good response...
  19. pmc Low pressure giant pulmonary artery aneurysms in the adult: natural history and management strategies
    G R Veldtman
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Heart 89:1067-70. 2003
    ..To describe aspects of the natural history and pathophysiology of giant low pressure pulmonary artery aneurysms and to propose potential surgical strategies...
  20. ncbi Surgical exclusion of a thrombosed azygos vein aneurysm causing pulmonary embolism
    Yoshitsugu Nakamura
    Department of Cardiovascular Surgery, Kanto Medical Center NTT EC, Tokyo, Japan
    J Thorac Cardiovasc Surg 133:834-5. 2007
  21. doi Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic eastern Finnish patients
    Terhi Huttunen
    Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    Neurosurgery 66:631-8; discussion 638. 2010
    Finnish saccular intracranial aneurysm (sIA) disease associates to 2q33, 8q11, and 9p21 loci and links to 19q13, Xp22, and kallikrein cluster in sIA families...
  22. ncbi Pulmonary vasculitis in behcet disease: a cumulative analysis
    Oguz Uzun
    Department of Pilmonary Medicine, Faculty of Medicine, Ondokuz Mayis University, Tip Fak, Göğüs Hst ABD 55139, Kurupelit Samsun, Turkey
    Chest 127:2243-53. 2005
    ....
  23. ncbi Hughes-Stovin syndrome: is it incomplete Behçet's? Report of two cases and review of the literature
    Yasser Emad
    Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt
    Clin Rheumatol 26:1993-6. 2007
    ..Both patients were treated successfully with steroids and immunosuppressive therapy and showed clinical improvement...
  24. ncbi CT angiography of pulmonary artery aneurysms in Hughes-Stovin syndrome
    Eric S Ketchum
    Department of Radiology, Thoracic Imaging Section, Stanford University Medical Center, 300 Pasteur Dr, Rm S 072, Stanford, CA 94305 5105, USA
    AJR Am J Roentgenol 185:330-2. 2005
  25. ncbi Embolization of a renal artery aneurysm using ethylene vinyl alcohol copolymer (Onyx)
    Tommaso Lupattelli
    Department of Radiology, St George s Hospital, London, England, UK
    J Endovasc Ther 10:366-70. 2003
    To report the embolization of a renal artery aneurysm using Onyx, a radiopaque nonadhesive liquid embolic agent.
  26. doi Surgical repair of true gastroduodenal artery aneurysm: a case report
    Yukihiro Matsuno
    Department of Cardiovascular Surgery, Gifu Prefectural General Medical Center, Gifu, Japan
    Vasc Endovascular Surg 42:497-9. 2008
    ..As risk for rupture is unrelated to size, any gastroduodenal artery aneurysm should be considered for definitive treatment once the diagnosis has been made...
  27. doi Computer-assisted microaneurysm turnover in the early stages of diabetic retinopathy
    Rui Bernardes
    Center of New Technologies for Medicine, University of Coimbra, Portugal
    Ophthalmologica 223:284-91. 2009
    ..To assess the reliability of microaneurysm turnover, computed from color fundus photographs, in evaluating diabetic retinopathy in patients with type 2 diabetes and nonproliferative retinopathy...
  28. ncbi Repair of aortic arch coarctation and innominate artery aneurysm with branched Dacron graft
    John S Ikonomidis
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston 29464, USA
    J Thorac Cardiovasc Surg 127:579-81. 2004
  29. doi Recurrence of a popliteal venous aneurysm
    Garietta Falls
    Department of Vascular Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Vasc Surg 51:458-9. 2010
    We report the case of a 40-year-old man with a recurrent popliteal vein aneurysm diagnosed 2 years after initial lateral aneurysmectomy...
  30. ncbi Aneurysm of the gastroduodenal artery associated with absence of the celiac axis: report of a case
    Keiji Iyori
    Department of Surgery, Yamanashi Kosei Hospital, Yamanashi, Japan
    Surg Today 34:360-2. 2004
    A 65-year-old woman was referred to us for treatment of an aneurysm, found incidentally by abdominal ultrasonography. Angiography demonstrated a saccular aneurysm of the gastroduodenal artery and absence of blood flow from the celiac axis...
  31. doi Adalimumab treatment for life threatening pulmonary artery aneurysm in Behçet disease: a case report
    Sung Won Lee
    Department of Internal Medicine, Dong A University, College of Medicine, Busan, Korea
    Clin Rheumatol 29:91-3. 2010
    ..We report that the inhibition of TNF-alpha using the neutralizing monoclonal antibody adalimumab has the potential to induce rapid, complete, and long-lasting remission in a life-threatening manifestation of BD...
  32. doi Laparoscopic surgery for splenic artery aneurysm
    Toru Obuchi
    Department of Surgery, Iwate Medical University School of Medicine, Japan
    Surg Laparosc Endosc Percutan Tech 19:338-40. 2009
    We describe 6 cases of laparoscopic splenectomy for multiple, fusiform splenic artery aneurysm (SAA) in patients difficult to treat with interventional radiology procedure and present a literature review.
  33. ncbi Surgical treatment for intrathoracic aneurysm of the innominate artery in an 83-year-old asymptomatic woman
    Kiyoaki Takaba
    Department of Cardiovascular Surgery, Japanese Red Cross Society Wakayama Medical Center, 4 20 Komatsubaradouri, Wakayama 640 8558, Japan
    Jpn J Thorac Cardiovasc Surg 52:194-7. 2004
    b>Aneurysm of the innominate artery is uncommon compared with other peripheral aneurysms, and holds the potential for rupture, embolization, or thrombosis as well as various complications caused by compression to the adjacent structures...
  34. ncbi True atherosclerotic aneurysm of the facial artery
    C do Carmo Galindo
    Vascular Surgery Service of the Maternidade Marieta Konder Bornhausen Hospital, Marcos Konder Av, 1111 Itajaí, SC, Brazil
    Int J Oral Maxillofac Surg 35:566-8. 2006
    True aneurysms of the facial artery are rare. This is the case report of a diabetic, hypertensive patient with a true aneurysm of the facial artery.
  35. ncbi Operative management of an aberrant splenic artery aneurysm: Utility of the medial visceral rotation approach: a case report and review of the literature
    Gennaro D LaBella
    Department of Surgery, Good Samaritan Hospital, Cincinnati, OH 45220, USA
    Vasc Endovascular Surg 40:331-3. 2006
    The authors report an unusual case of a splenic artery aneurysm arising off the superior mesenteric artery. This was an incidental finding on computed tomography scan found during evaluation for a different or a separate disease process.
  36. ncbi Renal artery aneurysm at the anastomosis after kidney transplantation
    L Asztalos
    First Department of Surgery, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Transplant Proc 38:2915-8. 2006
    Vascular complications represent serious problems after kidney transplantation. An aneurysm of the transplanted renal artery is an extremely rare but potentially devastating complication that which occurs in fewer than 1% of recipients...
  37. ncbi Treatment of a celiac trunk aneurysm close to the hepato-splenic bifurcation by using hepatic stent-graft implantation and splenic artery embolization
    Antonio Basile
    Department of Radiology, Ospedale Ferrarotto, via Citelli 16, Catania, Italy
    Cardiovasc Intervent Radiol 30:126-8. 2007
    We present a case of a 73-year-old man in whom a celiac trunk aneurysm close to the hepato-splenic bifurcation was discovered and treated by using celiac-hepatic stent-grafts implantation and splenic artery embolization.
  38. ncbi Managing anomalous splenic artery aneurysm: a review of the literature and report of two cases
    B Migliara
    Department of Surgery, Policlinico G B Rossi, University of Verona, Verona, Italy
    Ann Vasc Surg 19:546-52. 2005
    ..Finding these two anomalies in association is so rare that it is impossible to draw any final conclusions as to the best type of treatment. In the authors' experience, both surgery and percutaneous treatment can prove useful...
  39. ncbi Refinements in mathematical models to predict aneurysm growth and rupture
    Ramon Berguer
    Vascular Mechanics Laboratory, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 0329, USA
    Ann N Y Acad Sci 1085:110-6. 2006
    ..and eventually their likelihood of rupture depend on the determination of the stress and strain within the aneurysm wall and the exact reproduction of its geometry...
  40. ncbi Surgical treatment for innominate artery aneurysm with a coronary pulmonary artery fistula: a case report
    Akira Saito
    Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 11:55-8. 2005
    ..Pathologic diagnosis of the specimen was that of a true aneurysm with atherosclerotic plaque and calcification...
  41. ncbi Main pulmonary artery aneurysm
    Hsin Hung Shih
    Division of Cardiovascular Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC
    J Chin Med Assoc 70:453-5. 2007
    Pulmonary artery aneurysm is a rare lesion of the thoracic cavity. Different etiologies have been reviewed, but idiopathic lesions without other symptoms are seldom reported...
  42. ncbi Post-traumatic facial artery aneurysm in a child
    Craig L Stewart
    Department of Otolaryngology Head and Neck Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Int J Pediatr Otorhinolaryngol 68:1539-43. 2004
    ..We report here a case of a post-traumatic facial artery aneurysm which developed in a pediatric patient three weeks following a penetrating facial injury during motor vehicle ..
  43. pmc Complete regression of pulmonary vein aneurysm caused by mitral regurgitation
    J Beckert
    Heart 90:834. 2004
  44. doi Aneurysm of the femoral artery caused by aseptic loosening and migration of a Burch-Schneider cage
    Falk Mittag
    Department of Orthopaedic Surgery, University Tuebingen, Tuebingen, Germany
    J Arthroplasty 24:159.e9-159.e12. 2009
    ..We report a rare case of an aseptic loosened Burch-Schneider cage causing an aneurysm of the femoral artery and life-threatening bleeding, large hematoma, and signs of hyperfibrinolysis...
  45. ncbi Traumatic giant true aneurysm of the brachiocephalic artery
    Sai S Oruganti
    Department of Cardiology, Nizams Institute of Medical Sciences, Hyderabad 500 082, Andhra Pradesh, India
    Asian Cardiovasc Thorac Ann 14:352-3. 2006
  46. pmc A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation
    Brian L Hoh
    Department of Neurological Surgery, University of Florida, Gainesville, Florida 32610, USA
    Neurosurgery 66:544-50; discussion 550. 2010
    Although there are several large-species animal models for saccular aneurysms, there is a need for a simple, reproducible saccular aneurysm model in mice.
  47. doi Celiomesenteric trunk with concurrent aneurysm: report of a case
    Yi Wang
    Department of Radiology, Third Affiliated Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, PR China
    Surg Today 40:477-81. 2010
    This report describes a rare case of a common celiomesenteric anomaly with a concurrent aneurysm demonstrated by contrast-enhanced multidetector computed tomography (MDCT) angiography...
  48. doi Detection of ophthalmic artery occlusion by visual evoked potential during carotid-ophthalmic artery aneurysm clipping
    Takahiro Ota
    Department of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
    Br J Neurosurg 26:290-2. 2012
    We report an intriguing case of carotid-ophthalmic artery (OA) aneurysm surgery, in which the visual evoked potential (VEP) wave diminished during temporary OA occlusion...
  49. pmc Regulator of calcineurin 1 mediates pathological vascular wall remodeling
    Vanesa Esteban
    Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares CNIC, E 28029 Madrid, Spain
    J Exp Med 208:2125-39. 2011
    Artery wall remodeling, a major feature of diseases such as hypertension, restenosis, atherosclerosis, and aneurysm, involves changes in the tunica media mass that reduce or increase the vessel lumen...
  50. doi Fully percutaneous treatment of an aberrant right subclavian artery and thoracic aortic aneurysm
    Sameer Gafoor
    CardioVascular Center Frankfurt, Frankfurt, Germany
    Vasc Med 18:139-44. 2013
    Treatment of an aberrant right subclavian artery (arteria lusoria) aneurysm is traditionally performed surgically or via a hybrid approach. To our knowledge, a fully percutaneous approach has not yet been reported...
  51. doi Our experience of popliteal vein aneurysm
    Roberto Gabrielli
    Department of Vascular Surgery, Policlinico Casilino of Rome, Rome, Italy
    Interact Cardiovasc Thorac Surg 11:835-7. 2010
    ....
  52. doi Aneurysm of the aberrant right subclavian artery: surgical and hybrid repair of two cases in a single center
    Emanuele Ferrero
    Vascular and Endovascular Surgery Unit, Mauriziano Umberto I Hospital, Turin, Italy
    Ann Vasc Surg 25:839.e5-9. 2011
    The aberrant right subclavian artery (ARSA) aneurysm is rare; however, the risk of rupture and thromboembolism is high, with a postrupture mortality rate of 50%. In this report, we have described two cases of this anomaly...
  53. ncbi Treatment of splenic artery aneurysm with use of a stent-graft
    Aravind Arepally
    Russell H Morgan Department of Radiology and Radiological Science, Department of Surgery, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287, USA
    J Vasc Interv Radiol 13:631-3. 2002
  54. doi Saccular aneurysm of graft renal artery: case report
    P De Rosa
    O U General Surgery and Renal Transplantation, A O U OO RR San Giovanni di Dio and Ruggi D Aragona Hospital, Salerno, Italy
    Transplant Proc 43:1213-4. 2011
    ..Our report describes a case of a saccular aneurysm of the donor kidney, renal artery, which was identified during harvesting and repaired on the back-table using a ..
  55. doi Combined resection of coronary and innominate artery aneurysms
    Ashwini Oswal
    Jaslok Hospital, Mumbai, India
    J Card Surg 26:319-21. 2011
    ..We present the case of a 28-year-old male with an aneurysm of the left anterior descending coronary artery and an aneurysm of the inominate artery presenting with ..
  56. doi Endovascular repair of an internal mammary artery aneurysm in a patient with Loeys-Dietz syndrome
    John Westley Ohman
    Department of Cardiothoracic and Vascular Surgery, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Vasc Surg 55:837-40. 2012
    ..with a previous history of multiple open aortic repairs who presented with a right large internal mammary artery aneurysm. The patient was successfully treated with endovascular coil embolization...
  57. ncbi Central retinal artery occlusion in association with an aneurysm of the internal carotid artery
    C Haritoglou
    Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany
    Am J Ophthalmol 132:270-1. 2001
    ..The fovea was spared by a cilioretinal arteriole. RESULTS: Cerebral angiography showed an aneurysm of the left internal carotid artery, measuring approximately 1.7 x 1.5 x 1.7 cm...
  58. doi Transcatheter coil embolization of an aneurysm of an anomalous splenic artery: usefulness of double microcatheter method
    Noboru Tanigawa
    Department of Radiology, Kansai Medical University, Hirakata Hospital, 2 3 1 Shinmachi, Hirakata, Osaka, 573 1191, Japan
    Minim Invasive Ther Allied Technol 18:311-4. 2009
    Transcatheter embolization using two microcatheters of different shapes was performed to treat a 34-mm-diameter aneurysm that was located near the origin of a splenic artery that originated from the superior mesenteric artery (SMA)...
  59. doi Spontaneous axillary artery aneurysm: a case report and review of the literature
    Manmeet K Malik
    Division of Vascular Surgery, New York Hospital Queens, Flushing, NY 11355, USA
    Vascular 20:46-8. 2012
    ..Prompt treatment should be employed in the management of this condition. We report a case of an atraumatic degenerative axillary artery aneurysm that was treated with transaxillary open surgical bypass.
  60. ncbi A steady flow analysis on the stented and non-stented sidewall aneurysm models
    S C Yu
    Thermal and Fluids Engineering Division, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore
    Med Eng Phys 21:133-41. 1999
    As part of a general investigation on the effects of blood flow patterns in sidewall aneurysm, in vitro steady flow studies on rigid aneurysm models have been conducted using Particle Image Velocimetry over a range of Reynolds number from ..
  61. doi A tissue-engineered aneurysm model for evaluation of endovascular devices
    Jeremy S Touroo
    Cardiovascular Innovation Institute, University of Louisville and Jewish Hospital, Louisville, Kentucky, USA
    J Biomed Mater Res A 100:3189-96. 2012
    ..With this in mind, the focus of this work was to develop an aneurysm model consisting of human blood vessel cells...
  62. ncbi False aneurysm of the brachial artery: an unusual complication following accidental puncture by a patient on home haemodialysis
    L D Coen
    Department of Transplant and Vascular Surgery, Royal Hallamshire Hospital, Sheffield
    Br J Clin Pract 44:202-3. 1990
    A case is reported of false aneurysm of the brachial artery following accidental puncture during attempted cannulation of the median cubital vein for routine haemodialysis at home...
  63. doi Combined endovascular repair of a celiac trunk aneurysm using celiac-splenic stent graft and hepatic artery embolization
    Giampaolo Carrafiello
    Department of Radiology, Interventional Radiology, Varese University Hospital, University of Insubria, Varese, Italy
    Cardiovasc Intervent Radiol 33:352-4. 2010
    ..We report a case of a 70-year-old man who sought care for a celiac trunk aneurysm close to the hepatosplenic bifurcation managed endovascularly by using a combined treatment of celiac-splenic ..
  64. ncbi Endovascular repair of intrathoracic left subclavian artery aneurysm with stent grafts: report of a case and review of the literature
    Gian Franco Veraldi
    I Divisione Clinicizzata di Chirurgia Generale, Universita degli Studi di Verona
    Chir Ital 57:355-9. 2005
    ..We present the case of a large true aneurysm of the left intrathoracic subclavian artery that was successfully treated with two stent grafts on March 2001...
  65. doi Algorithms for the automated detection of diabetic retinopathy using digital fundus images: a review
    Oliver Faust
    Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore, Singapore
    J Med Syst 36:145-57. 2012
    ..However, this review shows that the classification results improved has improved recently, and it is getting closer to the classification capabilities of human ophthalmologists...
  66. ncbi Intrathoracic aneurysm of the innominate and right subclavian arteries: report of a case
    F Kasashima
    First Department of Surgery, Kanazawa University School of Medicine, Ishikawa, Japan
    Surg Today 31:51-4. 2001
    ..man who presented with facial anhidrosis that developed several years after blunt thoracic trauma, in whom an aneurysm involving the innominate and subclavian arteries was revealed by preoperative examinations...
  67. ncbi Rabbit aneurysm model mediated by the application of elastase
    Kuri Sasaki
    Department of Neurosurgery, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neurol Med Chir (Tokyo) 44:467-73, discussion 473-4. 2004
    The concentrations and application methods of elastase in the rabbit aneurysm model were optimized to control the initiation of aneurysms and to cause rupture in a stepwise, controlled fashion...
  68. ncbi A non-bleeding complex intracerebral giant aneurysm case: case report
    Feyzi Birol Sarica
    Baskent University Faculty of Medicine, Neurosurgery, Ankara, Turkey
    Turk Neurosurg 18:236-40. 2008
    An intracranial aneurysm with a diameter larger than 25 mm is considered a giant aneurysm (GA), and represent about 3-5% of all aneurysms. They are divided into two forms, specifically saccular and fusiform...
  69. ncbi Surgical repair of an aberrant splenic artery aneurysm: report of a case
    Giulio Illuminati
    The Francesco Durante Department of Surgery, University of Rome La Sapienza, Rome, Italy
    Ann Vasc Surg 21:216-8. 2007
    ..We report one more case of aneurysm of an aberrant splenic artery, treated with surgical resection, and preservation of the spleen.
  70. ncbi Primary popliteal venous aneurysm
    Andrew L Tambyraja
    Edinburgh Vascular Surgical Service, Royal Infimary of Edinburgh, Scotland
    J Vasc Surg 40:830. 2004
  71. ncbi Laparoscopic management of splenic artery aneurysms
    Uthaiah Kokkalera
    Department of Surgery, Guthrie Clinic, Sayre, Pennsylvania 18840, USA
    J Laparoendosc Adv Surg Tech A 16:604-8. 2006
    ..Historically, the surgical approach to their management has consisted of laparotomy with resection of the aneurysm and a possible splenectomy...
  72. doi Metalloproteinase expression in venous aneurysms
    Chance Irwin
    Division of Vascular Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    J Vasc Surg 48:1278-85. 2008
    ..Although recognized with increasing frequency, the pathogenesis of venous aneurysms (VA) remains poorly understood. We evaluated 8 patients with 10 VA for the presence, localization and activity of metalloproteinases (MMPs)...
  73. ncbi Nitrogen-rich coatings for promoting healing around stent-grafts after endovascular aneurysm repair
    Sophie Lerouge
    Research Center, Centre Hospitalier de l Universite de Montreal, Montreal, QC, Canada
    Biomaterials 28:1209-17. 2007
    Complications following endovascular aneurysm repair (EVAR) are related to deficient healing around the stent-graft (SG). New generations of SG with surface properties that foster vascular repair could overcome this limitation...
  74. ncbi Combined percutaneous endovascular and open surgical approach in the treatment of a persistent sciatic artery aneurysm presenting with acute limb-threatening ischemia--a case report and review of the literature
    Gregorio Maldini
    Department of Surgery, Straub Clinic and Hospital, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    Vasc Endovascular Surg 36:403-8. 2002
    ..Persistent sciatic artery aneurysm (PSAA) was first described in 1864...
  75. ncbi Delayed post-traumatic aneurysms of aorta, carotid and innominate arteries
    B Chiappini
    Department of Cardiovascular Surgery, Policlinico S Orsola, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    Eur J Cardiothorac Surg 20:1246-8. 2001
    ..We report here, to our knowledge, the first successful case of combined treatment (surgical and by interventional neuroradiology) in a patient with delayed post-traumatic aneurysms of the aorta, carotid and innominate arteries...
  76. doi The posterior approach in the treatment of popliteal artery aneurysm: feasibility and analysis of outcome
    Francesco Zaraca
    Department of Vascular and Thoracic Surgery, Regional Hospital Bozen, Bozen, Italy
    Ann Vasc Surg 24:863-70. 2010
    ....
  77. ncbi Innominate artery aneurysm
    Alexandra A MacLean
    Weill Medical College, Cornell University, United States
    Eur J Cardiothorac Surg 32:803. 2007
  78. ncbi Massive lower gastrointestinal tract bleeding due to splenic artery aneurysm: a case report
    Sanjiv Rao
    Department of Surgery, Mount Sinai Medical Center, Miami, FL, USA
    Ann Vasc Surg 21:388-91. 2007
    True aneurysm of the splenic artery is the third most common intraabdominal aneurysm and constitutes 60% of all visceral aneurysms. The incidence of splenic artery aneurysms ranges from 0.01% to as high as 10.4% in the elderly...
  79. doi Late-appearing brachiocephalic aneurysm: an atypical vascular sequella of Kawasaki disease
    Gaby Yang
    Division of Pediatric Cardiology, Department of Pediatrics, IWK Health Centre, Dalhousie University, P O Box 9700, Halifax, NS, Canada, B3K 6R8
    Pediatr Cardiol 30:197-9. 2009
    ..This report presents a case of KD with atypical findings of a late-appearing brachiocephalic artery aneurysm. The authors suggest that for patients with complicated KD, surveillance should include a careful vascular survey ..
  80. doi Fenestration of supraclinoid internal carotid artery and associated aneurysm: embryogenesis, recognition, and management
    Mahua Dey
    Division of Biological Sciences, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA
    World Neurosurg 76:592.e1-5. 2011
    ..Here we report two cases with successful surgical clipping of associated saccular aneurysms, and we systematically review the 12 previously reported cases...
  81. doi Endovascular treatment of symptomatic persistent sciatic artery aneurysm: a case report and review of literature
    Albeir Mousa
    Robert C Byrd Health Sciences Center, West Virginia University, Charleston, WV, USA
    Vasc Endovascular Surg 44:312-4. 2010
    ..b>Aneurysm formation complicates 40% to 61% of the PSA cases brought to medical attention...
  82. ncbi Giant aneurysm of the splenic artery in an elderly man short report and review of the literature
    Fabio Zampieri
    General and Emergency Surgery Unit, Department of Surgery, University of Pisa, Italy
    Ann Ital Chir 76:275-9. 2005
    ..Splenic Artery Aneurysms (SAAs) are usually single and small lesions, and their size rarely exceed 3 cm. In a review of the literature from 1950 to date, only 18 aneurysms defined as "giant" were found in 15 reported papers...
  83. doi Transplantation of kidneys with renal artery aneurysm
    Santosh A Olakkengil
    Department of Surgery Renal Transplantation Unit, The Queen Elizabeth Hospital, Woodville, SA, Australia
    Clin Transplant 25:E516-9. 2011
    ..Published literature on the outcome of transplanted kidneys with correctable vascular pathology has been reviewed...
  84. ncbi A case of gastroduodenal artery aneurysm in a HIV-positive patient treated by combined percutaneous thrombin injection and endovascular coil embolization
    G Piffaretti
    Department of Surgery, University of Insubria, Viale Borri 57, Varese, Italy
    J Cardiovasc Surg (Torino) 49:659-61. 2008
    ..e. HIV+). We report a case of a young patient affected by a HIV-related gastroduodenal artery aneurysm which was treated with a combined percutaneous and endovascular approach.
  85. doi Innominate artery aneurysm with hemoptysis and airway compression in a patient with bovine aortic arch
    Ivan Constenla
    Section of Vascular and Endovascular Surgery, Hospital Universitario Vall d Hebron, Universidad Autonoma de Barcelona, Barcelona, Spain
    J Vasc Surg 56:822-5. 2012
    ..5-cm (diameter) aneurysm of the innominate artery that compressed the trachea and obliterated the right subclavian artery...
  86. ncbi Transplanting a kidney with a renal artery aneurysm--a case report and literature review
    B Chiu
    Division of Vascular Surgery, Department of Surgery, Northwestern University Medical School, Chicago, IL, USA
    Vasc Surg 35:321-4. 2001
    As a rare postoperative complication, renal artery aneurysm has been reported in 0.95% of kidney transplants. A renal artery aneurysm was repaired prior to transplantation of the kidney.
  87. ncbi Surgical treatment of ascending aorta and innominate artery trunk aneurysm with displaced brachiocephalic vessels
    Uberto Da Col
    Department of Cardiac Surgery, Ospedale Silvestrini, Perugia, Italy
    J Cardiovasc Med (Hagerstown) 8:852-4. 2007
    ..Nevertheless, the presence of a significant innominate artery trunk aneurysm implies an adaptation of the surgical options available...
  88. ncbi Aneurysm of the popliteal artery in neurofibromatosis
    Yong Pil Cho
    Department of Surgery, University of Ulsan College of Medicine, Gangneung Asan Hospital, 415 Bangdong Ri, Sacheon myeon, Gangneung si, Gangwon Do, Republic of Korea
    Ann Vasc Surg 19:900-3. 2005
    ..In this report, we discuss the case of a 66-year-old woman with type 1 neurofibromatosis and a popliteal artery aneurysm who was operated upon because of threatened limb ischemia...
  89. doi Laparoscopic treatment of splenic artery aneurysms
    Andrea Pietrabissa
    Divisione di Chirurgia I Universitaria, Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Universita di Pisa, Pisa, Italy
    J Vasc Surg 50:275-9. 2009
    ..The purpose of this study was to report a series of 16 consecutive patients who underwent laparoscopic treatment of splenic artery aneurysms...
  90. doi Celiac artery aneurysm repair in Behcet disease complicated by recurrent thoracoabdominal aortic aneurysms
    Brant W Ullery
    Department of Vascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Vasc Endovascular Surg 44:146-9. 2010
    ..Herein, we report a 19-year-old male who initially presented with an isolated celiac artery aneurysm that was treated with open surgical repair...
  91. doi The effect of stent porosity and strut shape on saccular aneurysm and its numerical analysis with lattice Boltzmann method
    Yong Hyun Kim
    Department of Mechanical Engineering, Wayne State University, Detroit, MI, USA
    Ann Biomed Eng 38:2274-92. 2010
    ..is to study the effect of the stent strut shape and porosity on the hemodynamic properties of the flow inside an aneurysm using a numerical analysis...
  92. ncbi Left cervical aortic arch associated with aortic aneurysm, aortic coarctation, and branch artery aneurysm--a case report and review
    Osamu Tsukamoto
    Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Angiology 54:257-60. 2003
    ..Although, in CAA, other cardiovascular abnormalities including aortic aneurysm and aortic coarctation are occasionally accompanied, coexistence of those 2 aortic abnormalities on the same ..
  93. doi Saccular neck venous aneurysm on color duplex sonography: an analysis of 12 cases
    Chaoyang Wen
    Department of Ultrasound, Chinese PLA General Hospital, Beijing, People s Republic of China
    Clin Imaging 33:424-9. 2009
    To discuss the characteristics of saccular neck venous aneurysm on color duplex sonography.
  94. doi Supra-aortic vessels aneurysms: diagnosis and prompt intervention
    Marcelo Cury
    Department of Vascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Vasc Surg 49:4-10. 2009
    ..Aneurysms involving the supra-aortic vessels are rare but carry serious risk of embolization, thrombosis, and rupture. We describe our experience with the diagnosis, treatment strategies, and outcomes in patients with extended follow-up...
  95. doi Femoral profunda artery aneurysm as an unusual first presentation of Behcet disease
    Elizabeth A O'Leary
    Vascular Surgery, Washington Hospital Center, Washington, DC, USA
    Vasc Endovascular Surg 45:98-102. 2011
    ..He was also found to have a synchronous hypogastric artery aneurysm. The patient was immediately treated with corticosteroids and infliximab to control systemic and vascular ..
  96. ncbi Transcatheter coil embolization of splenic artery aneurysm
    Satoshi Yamamoto
    Department of Radiology, Hyogo College of Medicine, P O Box 663 8501, 1 1 Mukogawa cho, Nishinomiya, Japan
    Cardiovasc Intervent Radiol 31:527-34. 2008
    ..was to evaluate clinical results and technical problems of transcatheter coil embolization for splenic artery aneurysm. Subjects were 16 patients (8 men, 8 women; age range, 40-80 years) who underwent transcatheter embolization for ..
  97. doi A spontaneous true aneurysm of the superficial temporal artery treated by surgical resection
    Takashi Sakamoto
    Department of Otolaryngology and Head and Neck Surgery, The University of Tokyo, Japan
    Auris Nasus Larynx 38:119-22. 2011
    An aneurysm of the superficial temporary artery (STA) has a rarer occurrence than intracranial aneurysm. However, traumatic aneurysms of the STA are not unusual and have been reported about more than 400 cases...
  98. pmc Incidental splenic artery aneurysm
    R Kenningham
    Department of Surgery, Royal Liverpool University Hospital, Prescott Street, Liverpool L7 8XP, UK
    J R Soc Med 95:460-1. 2002
  99. doi Laparoscopic splenic artery aneurysm resection: review of current trends in management
    Jennifer Fong Ha
    Department of Vascular Surgery, University of Western Australia, Royal Perth Hospital, Perth, Western Australia
    Surg Laparosc Endosc Percutan Tech 19:e67-70. 2009
    Splenic artery aneurysm, although rare, is the commonest visceral aneurysm. Its management options have expanded with advances in minimally invasive techniques...
  100. ncbi Endovascular repair of an innominate artery true aneurysm
    P Puech-Leao
    Vascular Surgery Division, Faculty of Medicine, University of Sao Paulo, Brazil
    J Endovasc Ther 8:429-32. 2001
    To describe endovascular repair of a large aneurysm of the innominate artery in a patient with episodes of transient cerebral ischemia.
  101. ncbi Laparoscopic ligation of splenic artery aneurysm
    Rebecca M Sandford
    Department of Surgery, Level 2 RKCSB, Leicester Royal Infirmary, Leicester, UK
    Surg Laparosc Endosc Percutan Tech 16:102-3. 2006
    ..Presented is a case report describing laparoscopic ligation of a splenic artery aneurysm after failed attempt at embolization.

Research Grants74

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..6/million) and GCTA (20-200/100,000) to the arterial inflammation associated with atherosclerosis and aneurysm formation...
  2. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..the thrombin non-cleavable OPN R153A knockin mice in inflammation, hemopoietic stem cell mobilization, aortic aneurysm, and cancer models...
  3. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..This might be an attractive option to "screen" patients for the activity of the aneurysm and provide guidance for the therapy in the individual patient...
  4. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..the leading cause of death in patients with ADPKD is due to cardiovascular complications such as hypertension, aneurysm, and hemorrhage of unclear pathogenesis...
  5. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
    ..The clinical relevance of this proposal is underscored by the increasing incidence of AAAs among the VA population and the limited treatment options that are currently available. ..
  6. Tissue Factor &Clot Formation In Abdominal Aortic Aneurysm
    ALBERT PHILLIP OWENS; Fiscal Year: 2013
    ..on understanding the initiation and progression of cardiovascular disease with a focus on abdominal aortic aneurysm. Like every other scientist, I hope to one day find an effective treatment to alleviate the suffering of ..
  7. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..Candidate: My long-term career goal is to become a leading clinician-scientist in the field of cerebral aneurysm research...
  8. Angiotensin II uncoupling of eNOS in hypertension
    HUA LINDA CAI; Fiscal Year: 2013
    ..the proposed studies is to investigate an innovative role of eNOS uncoupling in the formation of abdominal aortic aneurysm (AAA)...
  9. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..Utilizing Plg deficient (Plg-/-) mice in peritonitis and abdominal aortic aneurysm (AAA) models, our studies provide in vivo evidence that Plg/plasmin is required for macrophage recruitment and ..
  10. HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
    Hugh Rosen; Fiscal Year: 2010
    ..these inhibitors have the potential to provide novel therapeutic approaches to inhibit hypertension, aortic aneurysm, myocardial infarction, pulmonary fibrosis, arthritis, Alzheimer's disease, stroke, cancer, and inflammation...
  11. Atomic Force Microscopic Studies of Dissecting Aneurysm
    Paul J Boor; Fiscal Year: 2013
    ..rats (dams) during their third trimester, results in a vascular lesion in newborn pups known as dissecting aortic aneurysm, or DAA. DAA is the sudden tearing, or splitting of the layers of the muscular wall of the thoracic aorta...
  12. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..studies will provide novel insights regarding a previously unappreciated transcriptional pathway governing aortic aneurysm development...
  13. Smooth Muscle Differentiation and Maturation
    Shiyou Chen; Fiscal Year: 2013
    ..of several prominent cardiovascular disease states including atherosclerosis, congenital heart diseases, aortic aneurysm, hypertension, and restenosis...
  14. Microfibril Fragments: Biomarkers of Aortic Disease
    Lynn Y Sakai; Fiscal Year: 2010
    ..For both TAAs and AAAs, monitoring the size of the aneurysm is the only determinant currently used to project the need for elective surgery and to avoid dissection or ..
  15. Syndecan-1 in Aortic Aneurysm Formation
    Elliot Chaikof; Fiscal Year: 2012
    ..of the heparan sulfate proteoglycan syndecan-1 may provide an important mechanism that inhibits abdominal aortic aneurysm (AAA) formation by limiting proteolytic or inflammatory activity and by promoting local reparative responses...
  16. Transforming Growth Factor-beta Signaling Pathways in Thoracic Aortic Aneurysms
    Jeffrey A Jones; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thoracic aortic aneurysm (TAA) disease is a potentially devastating disease process which often causes death by rupture in the absence of symptoms...
  17. The roles of primary cilia in cardiovascular system
    SURYA NAULI; Fiscal Year: 2012
    ..a kidney disease, the majority of patients with PKD die due to cardiovascular complications such as hypertension, aneurysm, hemorrhage, etc...
  18. Molecular Biology of Marfan Syndrome
    Harry C Dietz; Fiscal Year: 2013
    ..Many manifestations of MFS, including aortic aneurysm and tear, are driven by excessive TGFbeta signaling, particularly the noncanonical ERK cascade, and can be ..
  19. The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    Tomoki Hashimoto; Fiscal Year: 2013
    ..We have developed a novel mouse model of intracranial aneurysm. In this model, spontaneous aneurysmal rupture occurs with a predictable time course...
  20. Regulation of AT1R-signaling and pathology in vessels through microRNA
    Sadashiva S Karnik; Fiscal Year: 2013
    ..There is potential relevance for this knowledge base in understanding normal functioning aorta, vasculature in brain, kidney and heart, as well as the pathology of heart failure, atherosclerosis and aortic aneurysm.
  21. Loss of Matrix Regulation and Aortic Aneurysm Development in vivo
    Hiromi Yanagisawa; Fiscal Year: 2013
    ..This observation led us to hypothesize that fibulin-4 deficiency contributes to aneurysm formation through dysregulated angiotensin II (AngII) signaling in SMCs...
  22. EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATION
    Jay D Humphrey; Fiscal Year: 2010
    ..vasospasm, the leading cause of morbidity and mortality in patients surviving the rupture of an intracranial aneurysm, correlates strongly with clot burden and clot clearance rates...
  23. Recurrent laryngeal nerve connective tissues as a factor in vocal fold paralysis
    Julie M Barkmeier-Kraemer; Fiscal Year: 2013
    ..individuals with idiopathic UVP may have damage to the RLN at the level of the aortic arch related to a thoracic aneurysm. An aneurysm, or alternatively, increased aortic compliance, would impose increased stretch and compression to ..
  24. Endovascular Magnetic Catheter for Interventional MRI
    STEVEN WILLIAM HETTS; Fiscal Year: 2013
    ..Several major public health threats, including ischemic stroke, brain aneurysm, solid tumors, atherosclerosis, and cardiac arrhythmias are currently diagnosed and treated endovascularly under ..
  25. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Although thoracic aortic aneurysm and dissection (TAAD) are not as common as some forms of vascular diseases, e.g. coronary artery disease, it is a clinically insidious disease with high fatality...
  26. Age-Dependent Mechanisms in Thoracic Aortic Aneurysms
    John S Ikonomidis; Fiscal Year: 2013
    ..Because thoracic aortic aneurysm (TAAs) occur most frequently in persons 60-70 years of age, it follows that over the next two decades the ..
  27. Bifunctional Nitric Oxide Donor Refractory to Nitrate Tolerance
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..and life-threatening condition that increases the risk of cardiovascular events such as stroke and aortic aneurysm. We are developing a novel drug that targets the basic mechanisms of refractory hypertension and has been shown ..
  28. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
    ..Our experienced collaborative and highly productive team of Familial Intracranial Aneurysm (FIA) Investigators at 27 original sites in North America, Australia and New Zealand accomplished and surpassed ..
  29. CCN3 and aortic aneurysm
    Zhiyong Lin; Fiscal Year: 2013
    ..In Aim 1, we will fully characterize the role of CCN3 in aortic aneurysm formation...
  30. Gender Specific Evolution of Abdominal Aortic Aneurysm Composition and Properties
    Jay D Humphrey; Fiscal Year: 2013
    Gender Specific Evolution of Aortic Aneurysm Composition and Properties PROJECT SUMMARY Aortic aneurysms are focal dilatations of the arterial wall that are increasingly responsible for significant mortality and morbidity...
  31. Angiotensin II, oxidative stress and aneurysm formation
    Neal L Weintraub; Fiscal Year: 2013
    ..The mechanisms responsible for aneurysm formation are poorly understood, which has impeded identification of effective medical therapies for this disease...
  32. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..An abdominal aortic aneurysm (AAA) is a condition in which the aorta, the main blood vessel in the abdomen, expands like a balloon...
  33. Molecular Imaging of Protease Activation in Aneurysm
    Mehran M Sadeghi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vascular diseases, including aortic aneurysm, are major causes of morbidity and mortality in the US...
  34. Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and Haptics
    P Pat Banerjee; Fiscal Year: 2010
    ..Today, about 85% of intracranial aneurysms are treated endovascularly, e.g., by aneurysm coiling. There are already commercial virtual reality trainers for aneurysm coiling, such as the Mentice VIST"...
  35. Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty; Fiscal Year: 2010
    ..The unifying hypothesis of this amended program project application is that angiotensin II promotes aneurysm formation by initiating regional-specific matrix degradation in the media of the abdominal aorta, leading to ..
  36. Immunity and the pathogenesis of abdominal aortic aneurysms
    JOHN HUNT LILLVIS; Fiscal Year: 2012
    ..disease in the aging population, with approximately 10% of the population over the age of 65 harboring an aneurysm. The mortality from AAA is approximately 15,000 deaths per year, ranking it as the 13th leading cause of death in ..
  37. ROS Mechanisms in BAV Aortopathy
    THOMAS GILLETTE GLEASON; Fiscal Year: 2013
    ..composition of expertise and has devised a novel approach to prove that ROS accumulation in BAV-ascending aortic aneurysm (TAA) specimens leads to de-differentiation of SMCs, abnormal extracellular matrix (ECM) composition and ..
  38. The Effects of KLF4 in experimental aortic aneurysm formation
    Gorav Ailawadi; Fiscal Year: 2013
    ..by increased SMC production of MMPs and downregulation of SMC contractile marker genes prior to experimental aneurysm formation...
  39. Identifying Epidemiological Risk Factors for Abdominal Aortic Aneurysm
    Weihong Tang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is a common disease in the elderly and an important public health problem...
  40. Human tissue-engineered blood vessels using induced pluripotent stem cells
    Yibing Qyang; Fiscal Year: 2013
    ..elastin (ELN), which is essential to mechanical properties of blood vessels, providing recoil and resistance to aneurysm and dilation...
  41. CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSIS
    EDWARD FRANKLIN PLOW; Fiscal Year: 2013
    ..Plg-Rs have been implicated include peritonitis, sepsis, lung injury, angiogenesis, restenosis, atherogenesis, aneurysm and the response to biomaterial implants...
  42. Genetic Predisposition To Thoracic Aortic Aneurysms/Dissections
    Dianna M Milewicz; Fiscal Year: 2013
    ..aortic aneurysms progressively enlarge over time and ultimately lead to acute aortic dissections (TAAD);if the aneurysm is surgically repaired prior to dissection premature deaths can be prevented...
  43. CEREBRAL FUNCTION AFTER HYPOTHERMIC CIRCULATORY ARREST
    Gabriele DiLuozzo; Fiscal Year: 2012
    ..with aneurysms involving both the abdominal and thoracic aorta cannot be treated and consequently die when the aneurysm ruptures...
  44. Gender Differences in Experimental Aortic Aneurysms
    GILBERT RIVERS UPCHURCH; Fiscal Year: 2012
    ..Overall hypothesis: Gender- related differences in aortic aneurysm formation are mediated by the hormonal (androgen: estrogen ratio) regulation of leukocyte trafficking into the ..
  45. The role of CDKN2B in AAA disease
    NICHOLAS JAMES LEEPER; Fiscal Year: 2013
    ..seek to elucidate the relationship between the intergenic risk-associated region of 9p21 and abdominal aortic aneurysm (AAA) disease...
  46. 3D Ultrasound Guidance of Interventional Devices
    Stephen William Smith; Fiscal Year: 2012
    ..in the development and application of interventional medical devices including vascular stents, aortic aneurysm stent grafts, vena cava filters, vascular occluders, cardiac occluders, prosthetic cardiac valves, and catheter ..
  47. Cerebral artery Ca2+ signaling & subarachnoid hemorrhage
    George Wellman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cerebral vasospasm following aneurysm rupture and subarachnoid hemorrhage (SAH) is a devastating disorder that inflicts disability and death upon thousands of individuals each year...
  48. Identification and study of the vascular disease gene at 9p21.3
    Thomas Quertermous; Fiscal Year: 2013
    ..addition to CHD, variants at C9CAR have been associated with other vascular diseases, including abdominal aortic aneurysm, stroke, and peripheral vascular disease...
  49. Polycystin function in zebrafish (PA-06-158)
    Iain A Drummond; Fiscal Year: 2013
    ..with extracellular matrix seen in a variety of ADPKD pathologies including cystic kidney disease, vascular aneurysm, abdominal wall hernia, pericardial effusion, and defects in chondrogenesis...
  50. DNA Variants and AAA Disease
    Philip S Tsao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) disease is a common, morbid and highly lethal disease. Prior studies indicate a strong genetic component to the disease involving multiple loci...
  51. Alternative splicing in the vascular response to pathological shear stress
    PATRICK ANDRIES MURPHY; Fiscal Year: 2013
    ..forces exerted by blood flow on the vascular endothelium play an essential role in atherosclerosis, as well as aneurysm growth and pathological vascular remodeling...
  52. A novel atherosclerosis locus on mouse chromosome 4
    CARRIE LYNN WELCH; Fiscal Year: 2013
    ..Interestingly, this region contains the mouse homology with a widely-replicated human locus for CHD and aneurysm. The major goals of this proposal are: I) identify the gene(s) underlying the murine Athsq1 locus;2) to determine ..
  53. Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms
    Alexei Bogdanov; Fiscal Year: 2009
    The incidence of fatal and non-fatal aneurysm rupture in US is approximately 30,000 annually...
  54. TGF-beta Complex Serves as a Mechanosensor in the Vascular Wall
    Emily Wilson; Fiscal Year: 2010
    ..contribute to the pathological remodeling associated with diseases such as atherosclerosis, hypertension, and aneurysm formation...
  55. Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and Haptics
    P Pat Banerjee; Fiscal Year: 2013
    ..provided by applicant): IMMERSIVETOUCH(R) VIRTUAL REALITY-HAPTIC NEUROSURGERY SIMULATOR: CRANIOTOMY AND ANEURYSM CLIPPING Founded by principal investigator Dr. Pat Banerjee, ImmersiveTouch,(R) Inc...
  56. Molecular mechanisms in Abdominal Aortic Aneuysm
    Bo Liu; Fiscal Year: 2013
    Abdominal aortic aneurysm is a common age related and potentially lethal disease that develops as the result of a complex interplay among chronic inflammation, extracelluar matrix (ECM) degradation, and impaired ECM biosynthesis ..
  57. Roles of SMC TGF-beta Signaling in Aortic Health and Aneurysm Formation
    David A Dichek; Fiscal Year: 2013
    ..Aim 3 will test the hypothesis that loss of SMC TGF-[unreadable] signaling in a mouse model of acquired aortic aneurysm formation (chronic angiotensin II infusion) will accelerate SMC damage and aneurysm growth...
  58. Aortic Wall Behavior as a Predictor of Aortic Aneurysm Growth
    Rabih A Chaer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) rupture is the 13th leading cause of death among individuals aged 65-85.1 Small AAA growth and rupture are highly variable between patients and over time...
  59. AMPK as a redox sensor and modulator
    Ming Hui Zou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAAs) is the most common form of aortic aneurysm and ruptured AAAs cause at least 15,000 deaths each year in the US...
  60. Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling and Inflammation
    Tomoki Hashimoto; Fiscal Year: 2013
    ..Our preliminary data using a newly developed mouse model of intracranial aneurysm show that ovariectomy (surgical menopause) increased the incidence of intracranial aneurysms in female mice...
  61. Quantitative Analysis of Relationships Among Hemodynamics, Thrombus, and Abdomina
    Seungik Baek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is the focal enlargement of the aorta in the abdomen and its rupture is the 3rd leading cause of sudden death in men older than 65 years in the US...
  62. Correlation of MMP activity with anatomic changes in the ruptured AAA wall
    SEAN JASON ENGLISH; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is a lethal disease, with significant public health ramifications as the population ages. AAA rupture is associated with a uniformly high mortality rate (80%)...
  63. Endovascular device and treatment for stabilizing aortic aneurysms
    MATTHEW FRANK OGLE; Fiscal Year: 2010
    ..non-existent) for patients with small or moderate aneurysms, which comprise the largest percentage of all aneurysm patients...
  64. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..An abdominal aortic aneurysm (AAA) is a condition in which the aorta, the main blood vessel in the abdomen, expands like a balloon...
  65. Constrictor / Mitogen Induced Remodeling of Cerebral Arterioles
    JAY HUMPHREY; Fiscal Year: 2009
    ..presenting with a subarachnoid hemorrhage (SAH), the most common cause of which is a ruptured intracranial aneurysm. This delayed process has traditionally been associated with a short-term but marked reduction in the lumen of a ..
  66. HYPOTHERMIA DURING INTRACRANIAL ANEURYSM SURGERY
    Michael Todd; Fiscal Year: 2003
    ..performed to obliterate the source of bleeding; as many as 25 percent of patients who undergo craniotomy for aneurysm clipping will have a new neurologic deficit when examined 12-24hrs postoperatively...
  67. Bioengineering Studies of Abdominal Aortic Aneurysm Fluid and Wall Dynamics
    ENDER FINOL; Fiscal Year: 2009
    ..DESCRIPTION (provided by applicant): This proposal is designed to investigate the central hypothesis that, once an aneurysm is diagnosed, the primary biomechanical determinant of rupture potential is the non-uniform arterial wall ..
  68. Transcriptional Regulation of Matrix Metalloproteinase-3 (MMP-3)
    RUTH BORGHAEI; Fiscal Year: 2007
    ..periodontitis), homozygosity for the higher- expressing 5T allele is associated with myocardial infarction and aneurysm, while the lower- expressing 6T allele is associated with atherosclerosis...
  69. REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Julius Guccione; Fiscal Year: 1999
    The global left ventricular dysfunction that is characteristic of left ventricular aneurysm (LVA) is associated with stretching of muscle fibers in the adjacent noninfarcted (border zone) region during isovolumic systole...
  70. Ethyl Nitrite and Subarachnoid Hemorrhage
    Huaxin Sheng; Fiscal Year: 2009
    Cerebral vasospasm develops following subarachnoid hemorrhage (SAH), especially in patients with aneurysm rupture and causes major neurological and cognitive deficits and death...
  71. Measuring the Efficacy of Endovascular Treatment of AAA
    Peter Faries; Fiscal Year: 2007
    ..Abdominal aortic aneurysms are a leading cause of death due to aneurysm rupture...
  72. THE ROLE OF WALL STRESS DISTRIBUTION IN ABDOMINAL AORTIC
    Mark Fillinger; Fiscal Year: 2001
    In the clinical management of patients with an abdominal aortic aneurysm (AAA), physicians have long sought the ability to reliably identify patients with a high risk of rupture and those who are relatively safe from rupture...
  73. SURGERY FOR ACUTE MYOCARDIAL INFARCTION
    L Edmunds; Fiscal Year: 2000
    ..determine how the left ventricle remodels and whether or not ischemic mitral regurgitation, left ventricular aneurysm or global left ventricular dilatation with progressive loss of ventricular function occurs...
  74. BIOMECHANICAL EVALUATION OF ABDOMINAL AORTIC ANEURYSM
    DAVID ALAN VORP; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Abdominal aortic aneurysm (AAA) is a focal enlargement of the infrarenal aorta. If left untreated, AAA will gradually expand until rupture, an event that carries a mortality rate of 90%...