vascular diseases

Summary

Top Publications

  1. ncbi Vascular calcification mechanisms
    Cecilia M Giachelli
    Bioengineering Department, Box 351720, University of Washington, Okanogan Lane, Bagley Hall, Seattle, WA 98195, USA
    J Am Soc Nephrol 15:2959-64. 2004
  2. ncbi Role of microRNAs in vascular diseases, inflammation, and angiogenesis
    Carmen Urbich
    Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cardiovasc Res 79:581-8. 2008
  3. pmc Oxidative stress and microRNAs in vascular diseases
    Alessandra Magenta
    Istituto Dermopatico del Immacolata IRCCS, Vascular Pathology Laboratory, Via dei Monti di Creta 104, Rome 00167, Italy
    Int J Mol Sci 14:17319-46. 2013
  4. ncbi BMP signaling in vascular diseases
    Jie Cai
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
    FEBS Lett 586:1993-2002. 2012
  5. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
  6. ncbi Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    Lorenz C Hofbauer
    Department of Gastroenterology, Philipps University, Marburg, Germany
    JAMA 292:490-5. 2004
  7. ncbi Endoglin in angiogenesis and vascular diseases
    Peter Ten Dijke
    Department of Molecular Cell Biology, Leiden University Medical Center, Building 2, Room R 02 022, Postzone S 1 P, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Angiogenesis 11:79-89. 2008
  8. ncbi Periodontal bacteremia and various vascular diseases
    T Iwai
    Tsukuba Vascular Center and Buerger Disease Research Institute, Tatsuzawa, Moriya city, Japan
    J Periodontal Res 44:689-94. 2009
  9. pmc Differentiation of multipotent vascular stem cells contributes to vascular diseases
    Zhenyu Tang
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Nat Commun 3:875. 2012
  10. ncbi Matrix metalloproteinase inhibition therapy for vascular diseases
    Andrew C Newby
    Bristol Heart Institute, University of Bristol, UK
    Vascul Pharmacol 56:232-44. 2012

Detail Information

Publications342 found, 100 shown here

  1. ncbi Vascular calcification mechanisms
    Cecilia M Giachelli
    Bioengineering Department, Box 351720, University of Washington, Okanogan Lane, Bagley Hall, Seattle, WA 98195, USA
    J Am Soc Nephrol 15:2959-64. 2004
    ..Whether or not vascular calcification can be reversed is not yet known, but exciting new studies suggest that this may be possible in the future...
  2. ncbi Role of microRNAs in vascular diseases, inflammation, and angiogenesis
    Carmen Urbich
    Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Cardiovasc Res 79:581-8. 2008
    ..Thus, the identification of miRNAs and their respective targets may offer new therapeutic strategies to treat vascular diseases such as atherosclerosis, to improve neovascularization after ischaemia, or to prevent tumour progression.
  3. pmc Oxidative stress and microRNAs in vascular diseases
    Alessandra Magenta
    Istituto Dermopatico del Immacolata IRCCS, Vascular Pathology Laboratory, Via dei Monti di Creta 104, Rome 00167, Italy
    Int J Mol Sci 14:17319-46. 2013
    Oxidative stress has been demonstrated to play a causal role in different vascular diseases, such as hypertension, diabetic vasculopathy, hypercholesterolemia and atherosclerosis...
  4. ncbi BMP signaling in vascular diseases
    Jie Cai
    Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
    FEBS Lett 586:1993-2002. 2012
    ..and mice showed that perturbations in BMP signaling lead to various diseases, such as skeletal diseases, vascular diseases and cancer...
  5. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  6. ncbi Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    Lorenz C Hofbauer
    Department of Gastroenterology, Philipps University, Marburg, Germany
    JAMA 292:490-5. 2004
    ..Moreover, alterations of the OPG/RANKL/RANK system have been implicated in vascular diseases. RANKL blockade (using OPG or RANK fusion proteins or RANKL antibodies) has prevented bone loss caused by ..
  7. ncbi Endoglin in angiogenesis and vascular diseases
    Peter Ten Dijke
    Department of Molecular Cell Biology, Leiden University Medical Center, Building 2, Room R 02 022, Postzone S 1 P, Postbus 9600, 2300 RC, Leiden, The Netherlands
    Angiogenesis 11:79-89. 2008
    ..These exciting advances provide opportunities for the development of new therapies for diseases with vascular abnormalities...
  8. ncbi Periodontal bacteremia and various vascular diseases
    T Iwai
    Tsukuba Vascular Center and Buerger Disease Research Institute, Tatsuzawa, Moriya city, Japan
    J Periodontal Res 44:689-94. 2009
    ..Serum titer levels of each bacterium are now available and have shown a significant relationship between severity and individual differences...
  9. pmc Differentiation of multipotent vascular stem cells contributes to vascular diseases
    Zhenyu Tang
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Nat Commun 3:875. 2012
    ..These findings support a new hypothesis that the differentiation of multipotent vascular stem cells, rather than the de-differentiation of smooth muscle cells, contributes to vascular remodelling and diseases...
  10. ncbi Matrix metalloproteinase inhibition therapy for vascular diseases
    Andrew C Newby
    Bristol Heart Institute, University of Bristol, UK
    Vascul Pharmacol 56:232-44. 2012
    ..This review documents the established actions of MMPs and their inhibitors in vascular pathologies and considers the prospects for translating these findings into new treatments...
  11. ncbi RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases
    F Lamoureux
    Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, EA3822, Universite de Nantes, Nantes Atlantique Universites, F 44035, Nantes, France
    Cell Mol Life Sci 64:2334-50. 2007
    ..interactions and activities as well as the current evidence for their participation in osteoimmunology and vascular diseases. In fine, the targeting of the OPG/RANK/RANKL axis as novel therapeutic approaches will be discussed.
  12. ncbi Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
    Jialiang Hu
    Rega Institute for Medical Research, Catholic University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Nat Rev Drug Discov 6:480-98. 2007
    ..that the use of selective inhibitors might lead to new therapies for acute and chronic inflammatory and vascular diseases. In this Review, we compare the major classes of MMP inhibitors and advocate that future drug discovery ..
  13. pmc The association between mood and anxiety disorders with vascular diseases and risk factors in a nationally representative sample
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    J Psychosom Res 70:145-54. 2011
    To investigate the association between mood and anxiety disorders and vascular diseases after controlling for vascular disease risk factors.
  14. ncbi The role of inflammation in vascular diseases
    G W Sullivan
    University of Virginia, Department of Medicine, Health Sciences Center, Charlottesville 22908, USA
    J Leukoc Biol 67:591-602. 2000
    ..This review focuses on the causes, the inflammatory processes involved, and possible strategies for decreasing vascular disease through regulation of the inflammatory response...
  15. ncbi Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases
    Leszek Kalinowski
    Department of Biochemistry, Ohio University, Athens, OH 45701, USA
    Circulation 109:2511-7. 2004
    ..We hypothesized that the differences in endothelial NO/O2-/ONOO- metabolism may highlight the potential predisposition to endothelial dysfunction and cardiovascular complications prevalent in blacks...
  16. pmc Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Kaohsiung, Taiwan
    Environ Health Perspect 111:155-59. 2003
    ..However, the prevalence of diabetes and related vascular diseases in the entire southwestern arseniasis-endemic and nonendemic areas remains to be elucidated...
  17. ncbi The role of information in supporting self-care in vascular conditions: a conceptual and empirical review
    Christian Blickem
    NIHR Collaboration for Leadership in Applied Health Research CLARHC for Greater Manchester, Health Sciences Research Group, The University of Manchester, Manchester, UK
    Health Soc Care Community 19:449-59. 2011
    ..g. tailored information, use of narratives and user generated content). Developing a framework for the effective use of information needs to take account the full range of the factors identified...
  18. ncbi Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy
    Cytokine 63:92-6. 2013
    ..6; p=0.01), while showing a negative correlation with RI (R=-0.5; p=0.03). The potential implications of our findings for the pathophysiology of CVD are discussed...
  19. ncbi VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection)
    Yibo Wang
    Sino German Laboratory for Molecular Medicine, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College and National Genome Center, Beijing, People s Republic of China
    Circulation 113:1615-21. 2006
    ..We hypothesized that VKORC1-dependent effects on the coagulation cascade and atherosclerosis would contribute to susceptibility for vascular diseases.
  20. ncbi Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, University of Naples, Italy
    Arch Pharm Res 32:1103-8. 2009
    ....
  21. ncbi Angiotensin II-mediated development of vascular diseases
    Alan Daugherty
    Department of Medicine, and the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Trends Cardiovasc Med 14:117-20. 2004
    ..The definition of the cellular mechanisms by which Ang II promotes these vascular pathologies may provide new therapeutic strategies...
  22. ncbi Vascular abnormalities in patients with neurofibromatosis syndrome type I: clinical spectrum, management, and results
    Gustavo S Oderich
    Division of Vascular Surgery, Mayo Clinic, Gonda Vascular Center, Rochester, MN 55905, USA
    J Vasc Surg 46:475-484. 2007
    ..Vascular abnormalities are a well-recognized manifestation of NF-I. The purpose of this study is to review the spectrum, management, and clinical outcome of patients with vascular abnormalities and NF-I...
  23. pmc Predictors of primary care referrals to a vascular disease prevention lifestyle program among participants in a cluster randomised trial
    Megan E Passey
    University of Sydney, Lismore, Australia
    BMC Health Serv Res 12:234. 2012
    ..This paper examines patient and practice predictors of referral to a lifestyle modification program (LMP) offered as part of a cluster randomised controlled trial (RCT) of prevention of vascular disease in primary care...
  24. ncbi The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting
    Jianguang Qi
    Department of Pediatrics, First Hospital of Peking University, Xi An Men Street No 1, 100034, Beijing, P R China
    Heart Vessels 19:81-8. 2004
    ..Nitric oxide, as a modifying factor, might be involved in the regulation of pulmonary vascular structural remodeling...
  25. ncbi Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases
    D J Beech
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U K
    Biochem Soc Trans 35:890-4. 2007
    ..is the VSMC (vascular smooth-muscle cell), a fascinating cell that contributes significantly to occlusive vascular diseases by virtue of its ability to 'modulate' to a cell that no longer contracts and arranges radially in the ..
  26. ncbi Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
    ..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
  27. ncbi Homocysteine lowering with folic acid and B vitamins in vascular disease
    Eva Lonn
    Population Health Research Institute, Hamilton General Hospital, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont
    N Engl J Med 354:1567-77. 2006
    ..Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease...
  28. pmc Mechanisms of oxidative stress and vascular dysfunction
    Z S Nedeljkovic
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Postgrad Med J 79:195-199; quiz 198-200. 2003
    ..In this review, the role of oxidative stress in mechanisms of vascular dysfunction is discussed, and potential antioxidant strategies are reviewed...
  29. ncbi RAGE, vascular tone and vascular disease
    David G S Farmer
    Integrative and Systems Biology, Faculty of Biological and Life Sciences, West Medical Building, University of Glasgow, G12 UQQ, United Kingdom
    Pharmacol Ther 124:185-94. 2009
    ..In addition to atherosclerosis and vascular diseases associated with diabetes, recent data from studies in transgenic mice overexpressing the RAGE ligand S100A4/..
  30. ncbi Magnetic resonance imaging permits in vivo monitoring of catheter-based vascular gene delivery
    X Yang
    Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Circulation 104:1588-90. 2001
    ..CONCLUSIONS: We present a technical development that uses high-resolution MR imaging as an in vivo imaging tool to monitor catheter-based vascular gene delivery...
  31. ncbi Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases
    Catherine C Neto
    Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA
    Mol Nutr Food Res 51:652-64. 2007
    ..have the potential ability to limit the development and severity of certain cancers and vascular diseases including atherosclerosis, ischemic stroke, and neurodegenerative diseases of aging...
  32. pmc Mortality in neurofibromatosis 1: an analysis using U.S. death certificates
    S A Rasmussen
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Hum Genet 68:1110-8. 2001
    ....
  33. ncbi Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis
    Michael Schoppet
    Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    J Clin Endocrinol Metab 89:4104-12. 2004
    ....
  34. ncbi Arterial stiffness, vascular disease, and risk of cardiovascular events
    Jay N Cohn
    Circulation 113:601-3. 2006
  35. ncbi Vascular calcification in chronic kidney disease
    Shuichi Jono
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    J Bone Miner Metab 24:176-81. 2006
    ..These findings suggest that the balance of inducers, such as phosphate, and inhibitors, such as MGP, fetuin-A, and others, are likely to control whether or not calcification occurs under pathological conditions...
  36. ncbi Vascular calcifications: pathogenesis, management, and impact on clinical outcomes
    Jorge B Cannata-Andia
    Bone and Mineral Research Unit, Instituto Reina Sofia de Investigacion, Hospital Universitario Central de Asturias, Universidad de Oviedo, Julian Claveria s n, Oviedo 33006, Spain
    J Am Soc Nephrol 17:S267-73. 2006
    ..Despite that new strategies may improve the management of vascular diseases and specifically have a positive impact on the high prevalence of vascular calcifications, still the best ..
  37. ncbi Molecular strategies to treat vascular diseases: circulating vascular progenitor cell as a potential target for prophylactic treatment of atherosclerosis
    Masataka Sata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo and PRESTO, Japan Science and Technology Agency, Kawaguchi
    Circ J 67:983-91. 2003
    ..the recent findings on circulating vascular precursors and describes the potential therapeutic strategies for vascular diseases, targeting mobilization, homing, differentiation and proliferation of circulating progenitor cells.
  38. ncbi CD40 ligand: a neo-inflammatory molecule in vascular diseases
    Ghada S Hassan
    Laboratoire d Immunologie Cellulaire et Moléculaire, Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Montréal QC H2X 1P1, Canada
    Immunobiology 217:521-32. 2012
    ..In addition, the CD40L system was demonstrated a major player in the pathology of vascular diseases, such as atherosclerosis and restenosis...
  39. ncbi Validity for use in research on vascular diseases of the SIDIAP (Information System for the Development of Research in Primary Care): the EMMA study
    Rafel Ramos
    Unidad de Investigación en Atención Primaria de Girona, IDIAP Jordi Gol, Institut Catala de la Salut, Girona, Espana
    Rev Esp Cardiol (Engl Ed) 65:29-37. 2012
    ..We sought to analyze the validity of the data used in the EMMA study based on data from the Information System for the Development of Research in Primary Care...
  40. ncbi Current status on plasma biomarkers for acute mesenteric ischemia
    Stefan Acosta
    Vascular Center, Skane University Hospital, Malmo, Sweden
    J Thromb Thrombolysis 33:355-61. 2012
    ..None of the proposed plasma-derived tests for acute mesenteric ischemia has as yet entered routine clinical practice. The proposed biomarkers need to be evaluated in a prospective clinical research project in patients with acute abdomen...
  41. ncbi Transfemoral aortic valve implantation new criteria to predict vascular complications
    Kentaro Hayashida
    Institut Cardiovasculaire Paris Sud, Massy, France
    JACC Cardiovasc Interv 4:851-8. 2011
    ..This study sought to evaluate the incidence, impact, and predictors of vascular complications in transcatheter aortic valve implantation (TAVI)...
  42. ncbi Initial imaging recommendations for Vasovist angiography
    Mike Hartmann
    EPIX Pharmaceuticals, 161 First Street Cambridge, MA 02142, USA
    Eur Radiol 16:B15-23. 2006
    ..Preliminary technical recommendations for the optimization of contrast-enhanced MRA with Vasovist can be deducted from current clinical trial experience in various vessel beds...
  43. ncbi Thiol compounds metabolism in mice, rats and humans: comparative study and potential explanation of rodents protection against vascular diseases
    Vasiliki Likogianni
    Assistance Publique Hopitaux de Paris, Service de Biochimie, Hopital Europeen Georges Pompidou, Paris, France
    Clin Chim Acta 372:140-6. 2006
    ..We investigated whether species-specific differences in thiols metabolism may explain the respective sensitivity of rodents and humans to hyperhomocysteinemia...
  44. ncbi Morbidity and mortality after bowel resection for acute mesenteric ischemia
    Prateek K Gupta
    Department of Surgery, Creighton University, Omaha, NE 68131, USA
    Surgery 150:779-87. 2011
    ....
  45. pmc Roles of transglutaminases in cardiac and vascular diseases
    David C Sane
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1045, USA
    Front Biosci 12:2530-45. 2007
    ..In this review, we summarize the cardiovascular biology of two members of the family of transglutaminases, Factor XIII and TG2...
  46. ncbi Telmisartan improves vascular function independently of metabolic and antihypertensive effects in hypertensive subjects with impaired glucose tolerance
    Sabine Perl
    Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Austria
    Int J Cardiol 139:289-96. 2010
    ..The aim of the present study was to compare vascular effects of telmisartan and losartan in relation to their metabolic and antihypertensive effects in hypertensive patients with IGT...
  47. pmc Validation of the murine aortic arch as a model to study human vascular diseases
    Christophe Casteleyn
    Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Anat 216:563-71. 2010
    ..thoracic aorta and its main branches are widely studied to gain more insight into the pathogenesis of human vascular diseases, detailed anatomical data on the murine aorta are sparse...
  48. ncbi A cluster randomised controlled trial of vascular risk factor management in general practice
    Mark F Harris
    Centre for Primary Health Care and Equity, University of New South Wales, Sydney, NSW, Australia
    Med J Aust 197:387-93. 2012
    ..To evaluate the impact of a lifestyle intervention in Australian general practice to reduce the risk of vascular disease...
  49. ncbi SIRT1 as a novel potential treatment target for vascular aging and age-related vascular diseases
    F Wang
    State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, New Building 507, Beijing, 100005, People s Republic of China
    Curr Mol Med 13:155-64. 2013
    Aging is one of the greatest risk factors in vascular diseases (VDs)...
  50. ncbi A study on 107 patients with acute mesenteric ischemia over 30 years
    Etem Alhan
    Department of Surgery, Karadeniz Technical University, Farabi Hospital, 61080 Trabzon, Turkey
    Int J Surg 10:510-3. 2012
    ..A high index of suspicion with prompt diagnostic evaluation with CT angiography may reduce time prior to surgical intervention which may lead to improved patient survival...
  51. pmc Platelets as cellular effectors of inflammation in vascular diseases
    Matthew T Rondina
    Department of Medicine and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
    Circ Res 112:1506-19. 2013
    ..Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.
  52. pmc Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis
    Paola Margutti
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    Blood 111:4559-70. 2008
    ..These findings suggest that autoantibodies to RLIP76 play a pathogenetic role in immune-mediated vascular diseases and represent a valuable peripheral blood bioindicator of atherosclerosis and immune-mediated vascular ..
  53. ncbi Percutaneous aortic valve replacement: vascular outcomes with a fully percutaneous procedure
    Stefan Toggweiler
    Department of Cardiology, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    J Am Coll Cardiol 59:113-8. 2012
    ..The aim of this study was to evaluate vascular complications in a consecutive patient population undergoing transfemoral percutaneous aortic valve replacement (PAVR) applying current Valve Academic Research Consortium definitions...
  54. pmc Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy
    Yoshihide Asano
    Arthritis Center, Boston University Medical Center, Boston, MA 02118, USA
    Am J Pathol 176:1983-98. 2010
    ..Importantly, vascular characteristics of Fli1 CKO mice are recapitulated by SSc microvasculature. Thus, persistently reduced levels of Fli1 in endothelial cells may play a critical role in the development of SSc vasculopathy...
  55. ncbi Risk of vascular events in emergency department patients discharged home with diagnosis of dizziness or vertigo
    Anthony S Kim
    Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
    Ann Emerg Med 57:34-41. 2011
    ..Given the concern that important diagnoses could be missed, we measure the incidence of subsequent major vascular events in patients after discharge home...
  56. pmc Uric acid, hyperuricemia and vascular diseases
    Ming Jin
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Front Biosci (Landmark Ed) 17:656-69. 2012
    ....
  57. ncbi Arterial wall-determined risk factors to vascular diseases: a nonhuman primate model
    Xing Li Wang
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Cell Biochem Biophys 40:371-88. 2004
    ..In the current review, we discuss the importance of arterial wall factors in vascular diseases and present a baboon model for practical studies of arterial wall factors and their interaction with ..
  58. ncbi Retinoids: pleiotropic agents of therapy for vascular diseases?
    Jeffrey W Streb
    Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Drug Targets Cardiovasc Haematol Disord 3:31-57. 2003
    ..Retinoid-response genes, therefore, represent promising targets of therapy for the refined treatment of vascular diseases. The purpose of this review is to summarize the emerging importance of retinoids in the control of vascular ..
  59. ncbi Venous stenosis in a pig arteriovenous fistula model--anatomy, mechanisms and cellular phenotypes
    Yang Wang
    Division of Nephrology, University of Cincinnati, Albert Sabin Way, Cincinnati, OH 45267 0585, USA
    Nephrol Dial Transplant 23:525-33. 2008
    ..The aim of this study was to develop and validate a pig model of AV fistula stenosis and then use it to dissect out the mechanisms responsible for this lesion...
  60. pmc Associations between vascular co-morbidities and depression in insulin-naive diabetes patients: the DIAZOB Primary Care Diabetes study
    B Koopmans
    Center of Research on Psychology in Somatic Diseases, Department of Medical Psychology, Tilburg University, The Netherlands
    Diabetologia 52:2056-63. 2009
    ..The aim of the study was to determine the prevalence of depression in insulin-naive diabetes patients and to investigate the associations between different forms of vascular co-morbidity and depression...
  61. ncbi Postpartum angiopathy with reversible posterior leukoencephalopathy
    Aneesh B Singhal
    Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Arch Neurol 61:411-6. 2004
    ..The pathophysiological features of RPLS are related to small-vessel dysfunction and breakdown of the blood-brain barrier...
  62. ncbi Vascular complications of transfemoral aortic valve implantation with the Edwards SAPIEN prosthesis: incidence and impact on outcome
    Gregory Ducrocq
    Department of Cardiology, Bichat Claude Bernard Hospital, Paris, France
    EuroIntervention 5:666-72. 2010
    ..Vascular complications remain the main limitation of transfemoral aortic valve implantation. Based on a single-centre experience, we aim to detail the type, management and impact of those vascular complications...
  63. ncbi Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyri
    Abdelouahid Samadi
    Laboratorio de Radicales Libres y Química Computacional IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
    Bioorg Med Chem 18:5861-72. 2010
    ..can be considered as attractive multipotent therapeutic molecules on two key pharmacological receptors playing key roles in the progress of Alzheimer, that is, cholinergic dysfunction and oxidative stress, and neuronal vascular diseases.
  64. ncbi Acute exacerbation of interstitial pneumonia associated with collagen vascular diseases
    Takafumi Suda
    2nd Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Respir Med 103:846-53. 2009
    ..However, the incidence of AE in CVD-IP and its clinical characteristics remain to be fully determined. This study was conducted to elucidate cumulative incidence of AE in CVD-IP and its clinical features...
  65. ncbi Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases
    Francisco R M Laurindo
    Vascular Biology Laboratory, Heart Institute InCor, University of Sao Paulo School of Medicine, Brazil
    Antioxid Redox Signal 10:1101-13. 2008
    ..These data may clarify an integrative view of oxidase activation in disease conditions, including stress responses...
  66. ncbi The microenvironment can shift erythrocytes from a friendly to a harmful behavior: pathogenetic implications for vascular diseases
    Maurizio Minetti
    Department of Cell Biology and Neurosciences, Istituto Superiore Sanita, Rome, Italy
    Cardiovasc Res 75:21-8. 2007
    ..In line with recent data from the literature, erythrocytes can be proposed as bioindicators of progression in chronic or acute diseases characterized, as a hallmark, by oxidative alterations...
  67. ncbi Vascular Ehlers-Danlos syndrome
    Dominique P Germain
    Clinical Genetics Unit, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France
    Ann Genet 47:1-9. 2004
    ....
  68. ncbi Molecular basis for arsenic-induced alteration in nitric oxide production and oxidative stress: implication of endothelial dysfunction
    Yoshito Kumagai
    Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Toxicol Appl Pharmacol 198:450-7. 2004
    ..studies have suggested that prolonged exposure of humans to arsenic in drinking water is associated with vascular diseases. The exact mechanism of how this occurs currently unknown...
  69. ncbi Graft vascular disease: immune response meets the vessel wall
    Richard N Mitchell
    Department of Pathology, Health Sciences and Technology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Pathol 4:19-47. 2009
    ..Because GVD shares many features with more common vascular pathologies, insights gleaned from our understanding of allograft vasculopathy may well impact our treatment for "traditional" atherosclerosis or restenosis lesions...
  70. ncbi Nitric oxide, oxidative excess, and vascular complications of diabetes mellitus
    Dierk H Endemann
    Clinical Research Institute of Montreal, 110 Pine Avenue W, Montreal, Quebec, Canada H2W 1R7
    Curr Hypertens Rep 6:85-9. 2004
    ..Advances in understanding the pathophysiologic mechanisms leading to vascular damage in diabetes will result in discovery of new therapeutic targets, which should help reduce cardiovascular risk in these patients...
  71. ncbi Algorithm for using a long-pulsed Nd:YAG laser in the treatment of deep cutaneous vascular lesions
    Don Groot
    University of Alberta, Canada
    Dermatol Surg 29:35-42. 2003
    ..New laser systems offer greater potential to treat these difficult lesions, but the lack of specific treatment guidelines has restricted consistent success...
  72. ncbi Analysis of risk factors for myocardial infarction and cardiac mortality after major vascular surgery
    J Sprung
    Department of General Anesthesiology, The Cleveland Clinic Foundation, OH 44195, USA
    Anesthesiology 93:129-40. 2000
    ..Patients undergoing vascular surgical procedures are at high risk for perioperative myocardial infarction (PMI). This study was undertaken to identify predictors of PMI and in-hospital death in major vascular surgical patients...
  73. ncbi Vascular effects of photodynamic therapy
    B Krammer
    Institute of Physics and Biophysics, University of Salzburg, Austria
    Anticancer Res 21:4271-7. 2001
    ..Successful application of PDT mainly for vessel occlusion and thrombosis in intimal hyperplasia, restenosis, atherosclerotic plaques, corneal and choroidal neovascularisation and port-wine stains is reported...
  74. ncbi Involvement of periodontopathic biofilm in vascular diseases
    K Okuda
    Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Mihama ku, Chiba, Japan
    Oral Dis 10:5-12. 2004
    ..We focus on the relationships between periodontal disease-associated bacteria forming biofilms and vascular diseases including atherosclerosis and carotid coronary stenotic artery disease, and we discuss the direct and ..
  75. ncbi Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity
    Jonathan C Choy
    The iCAPTUR4E Centre UBC McDonald Research Laboratories, Department of Pathology and Laboratory Medicine, St Paul s Hospital Providence Health Care University of British Columbia, Vancouver, British Columbia, Canada
    Mod Pathol 16:460-70. 2003
    ..These observations suggest that granzyme B-mediated apoptosis may contribute to the pathogenesis of these diseases...
  76. ncbi Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway
    Mariano Janiszewski
    Cellular Biology Laboratory, Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, Avenida Albert Einstein, Sao Paulo, Brazil
    Crit Care Med 32:818-25. 2004
    ....
  77. ncbi Proteinase-activated Receptor 2 (PAR2): a challenging new target for treatment of vascular diseases
    John J McGuire
    Cardiovascular Research Group, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    Curr Pharm Des 10:2769-78. 2004
    Proteinase-activated Receptor 2 (PAR2) is a potential target for the design of drug treatments for vascular diseases. Its unique mechanism of activation by serine proteinases, questions regarding the identities of endogenous agonists and ..
  78. ncbi Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases
    Y Yatomi
    Department of Laboratory Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Curr Pharm Des 12:575-87. 2006
    ..In this review, I will summarize recent findings on possible roles of Sph-1-P in vascular biology and its therapeutical implications...
  79. ncbi Pulmonary and vascular manifestations of Behcet disease: imaging findings
    Naim Ceylan
    Department of Radiology, Ege University School of Medicine, Bornova, Izmir, Turkey
    AJR Am J Roentgenol 194:W158-64. 2010
    ..CT is an important diagnostic imaging technique in the evaluation of patients with Behçet disease...
  80. ncbi Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction
    S Bo
    Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Endocrinol Invest 31:499-504. 2008
    ..The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are all linked to cardiovascular disease...
  81. ncbi Vascular complications with transcatheter aortic valve implantation using the 18 Fr Medtronic CoreValve System: the Rotterdam experience
    Nicolas M Van Mieghem
    Department of Cardiology, Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands
    EuroIntervention 5:673-9. 2010
    ..Access site complications, therefore, can be a concern. The aim of this study is to present the 30-day incidence of major and minor vascular complications in patients treated with the third generation 18 Fr Medtronic CoreValve System...
  82. ncbi Microparticles in vascular diseases
    Françoise Dignat George
    INSERM U 608, laboratoire d hématologie et d immunologie, Marseille, France
    Thromb Res 122:S55-9. 2008
    ..In these clinical settings, the pharmacological modulation of MP level or activity provides challenging issues...
  83. pmc Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow
    Joseph E Brayden
    Department of Pharmacology, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Clin Exp Pharmacol Physiol 35:1116-20. 2008
    ..g. hypertension, stroke, vasospasm)...
  84. ncbi Arterial calcification in diabetes
    Neal X Chen
    Department of Medicine, Indiana University School of Medicine, 1001 West 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Curr Diab Rep 3:28-32. 2003
    ..Further understanding of the mechanism by which diabetes induces this complication is needed to design effective therapeutic strategies to intervene with this process...
  85. ncbi Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I
    Mark A Creager
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1527-32. 2003
  86. ncbi Increased incidence of coronary atherosclerosis in type 2 diabetes mellitus: mechanisms and management
    R Todd Hurst
    Mayo Clinic, Scottsdale, Arizona 85259, USA
    Ann Intern Med 139:824-34. 2003
    ..However, patients with diabetes benefit more from treatments that reduce coronary artery disease risk...
  87. ncbi Contribution of B cells and antibody to cardiac allograft vasculopathy
    Alison Gareau
    Department of Surgery, Atlantic Centre for Transplantation Research, Microbiology and Immunology and Pathology, Dalhousie University, Halifax, NS, Canada
    Transplantation 88:470-7. 2009
    ..No studies have been conducted in the presence of a clinically relevant immunosuppressant. In our study, we use cyclosporin A, a calcineurin inhibitor...
  88. ncbi Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease
    John Kanellis
    Department of Nephrology and Medicine, University of Melbourne, Austin Hospital, Australia
    Semin Nephrol 25:39-42. 2005
    ..Experimental evidence suggests a complex but potentially direct causal role for uric acid in the pathogenesis of hypertension and atherosclerosis...
  89. ncbi Risk of elevated resting heart rate on the development of type 2 diabetes in patients with clinically manifest vascular diseases
    Remy H H Bemelmans
    Department of Vascular Medicine, Julius Center for Health Sciences and Primary Care Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Endocrinol 166:717-25. 2012
    ..Resting heart rate (RHR) reflects sympathetic nerve activity. We investigated the effect of RHR on the incidence of type 2 diabetes mellitus (T2DM) in patients with clinically manifest vascular diseases.
  90. ncbi Determinants of coronary vascular calcification in patients with chronic kidney disease and end-stage renal disease: a systematic review
    Peter A McCullough
    Department of Medicine, Divisions of Cardiology, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Nephrol 17:205-15. 2004
    ..Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are conditions associated with metabolic disorders related to soft tissue calcification...
  91. ncbi Vascular cell lines expressing SSAO/VAP-1: a new experimental tool to study its involvement in vascular diseases
    Montse Solé
    Institut de Neurociències i Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Biol Cell 103:543-57. 2011
    ..However, the study of this enzyme is difficult, owing to its loss of expression in cell cultures...
  92. ncbi Systematic appraisal of the management of the major vascular complications of pancreatitis
    Srinivasan Balachandra
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9RN, United Kingdom
    Am J Surg 190:489-95. 2005
    ..This study is a systematic appraisal of the management of major vascular complications of pancreatitis conducted by collating individual patient-episode data from published literature...
  93. ncbi The role of sex on VARC outcomes following transcatheter aortic valve implantation with both Edwards SAPIEN™ and Medtronic CoreValve ReValving System® devices: the Milan registry
    Gill Louise Buchanan
    Interventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy
    EuroIntervention 7:556-63. 2011
    ..To assess outcomes after transcatheter aortic valve implantation (TAVI) according to sex, with the two available valves and four recognised delivery approaches...
  94. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..We propose that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy...
  95. ncbi Genetic determinants of obesity and related vascular diseases
    Yaroslav Winter
    Department of Neurology, Philipps University, Marburg Germany
    Vitam Horm 91:29-48. 2013
    Obesity is one of the major risk factors of vascular diseases, and its prevalence is increasing worldwide. In the past decade, progress has been made in the understanding of genetic determinants of obesity and obesity-associated diseases...
  96. ncbi Antibiotics for vascular diseases: a meta-analysis of randomized controlled trials
    Kachi O Illoh
    Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Atherosclerosis 179:403-12. 2005
    Trials of antibiotic treatment of vascular diseases, in attempts to eradicate possible microbial initiators, have had mixed results...
  97. ncbi Low-dose, time-resolved, contrast-enhanced 3D MR angiography in cardiac and vascular diseases: correlation to high spatial resolution 3D contrast-enhanced MRA
    M S Krishnam
    Department of Radiological Sciences, University of California at Los Angeles, Los Angeles, CA 90095 7206, USA
    Clin Radiol 63:744-55. 2008
    ..time-resolved, three-dimensional (3D) magnetic resonance (MR) angiography (TR-MRA) in the assessment of various cardiac and vascular diseases, and to compare the results with high-resolution contrast-enhanced MRA (CE-MRA).
  98. pmc Migraine in women: the role of hormones and their impact on vascular diseases
    Simona Sacco
    Department of Neurology and Regional Referral Center for Headache Disorders, University of L Aquila, Piazzale Salvatore Tommasi, 1, 67100, L Aquila, Italy
    J Headache Pain 13:177-89. 2012
    ..Consequently, in women suffering from migraine with aura caution should be deserved when prescribing combined oral contraceptives...
  99. ncbi Intermittent intravenous cyclophosphamide pulse therapy for the treatment of active interstitial lung disease associated with collagen vascular diseases
    Makoto Okada
    Department of Internal Medicine, Division of Rheumatology, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Mod Rheumatol 17:131-6. 2007
    The availability of intravenous cyclophosphamide (CYC) pulse therapy for collagen vascular diseases (CVD)-associated interstitial lung disease (ILD) has been indicated...
  100. ncbi Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice
    Xue Gao
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA
    Circulation 115:245-54. 2007
    ..We hypothesized that the inflammatory cytokine tumor necrosis factor-alpha (TNF) produces endothelial dysfunction in type 2 diabetes...
  101. ncbi Adipocytokines - novel link between inflammation and vascular function?
    T J Guzik
    Department of Internal Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    J Physiol Pharmacol 57:505-28. 2006
    ..Moreover future treatments of metabolic system associated disorders should focus on the regulation of adipocytokines and their modes of action...

Research Grants69

  1. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..of new therapies resulting in improved outcomes and lower costs for treating pulmonary emphysema and vascular diseases, which is are common among veterans...
  2. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..Accumulating evidence indicates that one key factor that contributes to the pathogenesis of vascular diseases, including PAH, is an increase in reactive oxygen species, such as superoxide (O2-), that exceed antioxidant ..
  3. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases.
  4. Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zipper
    Xing Ming Shi; Fiscal Year: 2012
    ..and the diseases that are associated with excess body fat, such as insulin resistance and coronary vascular diseases. Peroxisome proliferators-activated receptor-gamma2 (PPAR(2), also known as the "master" regulator of ..
  5. Regulation of the Endothelial Citrulline-Nitric Oxide Cycle
    Duane C Eichler; Fiscal Year: 2010
    ..be used to prevent or inhibit vascular endothelial dysfunction found in diabetes, obesity and other related vascular diseases. PUBLIC HEALTH RELEVANCE Impairment of vascular wall function has been suggested to be an early, causative ..
  6. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
    ..on cardiovascular tissues that account for the majority of the protective effects of estrogen against vascular diseases. The direct effects of estrogen on the vasculature are mediated by two ligand-activated transcription ..
  7. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..provide a novel perspective for future studies to understand cardiovascular defects during development and vascular diseases. PUBLIC HEALTH RELEVANCE: Vascular complications are a leading cause of morbidity and mortality in a number ..
  8. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    ..balance, will provide novel insights that would lead to new strategies and paradigms in the management of vascular diseases. With the overwhelming prevalence of vascular disease nationally, and worldwide, new insights and strategies ..
  9. GPCR Signaling &Vascular Wall Remodeling
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Vascular smooth muscle cell (VSMC) migration and proliferation play an important role in peripheral vascular diseases such as atherosclerosis and restenosis following angioplasty or vein grafting...
  10. Endothelial Lipoxygenase Metabolites and Vascular Tone
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2013
    ..Therapeutic approaches restoring endothelial function represent promising new treatments for cardio- vascular diseases with a major impact on health...
  11. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..to various neurological disease with diminished CBF including Alzheimer's and vascular type dementia, vascular diseases such as vasospasm, amyloidosis, atherosclerosis, venous hypertension, and CSF hydrodynamic disorders such as ..
  12. Histone deacetylase 7 and its interacting proteins in endothelial cells
    Hung Ying Kao; Fiscal Year: 2013
    ..inflammation, proliferation, apoptosis, and angiogenesis may have therapeutic implications for treating vascular diseases. PUBLIC HEALTH RELEVANCE: Endothelial cells reprogram their transcriptional network in response to cytokine ..
  13. Heme Oxygenase Polymorphisms and Hepatopulmonary Syndrome
    KARI EVAN ROBERTS; Fiscal Year: 2012
    ..program is to develop scientific expertise in and new understanding of the pathophysiology of pulmonary vascular diseases such as Hepatopulmonary syndrome (HPS)...
  14. HIGH SALT DIET, ANGIOTENSIN II, AND MICROVESSEL DILATION
    Julian H Lombard; Fiscal Year: 2012
    ..occurring in rats and other species fed high salt diet are reminiscent of pathological alterations seen in vascular diseases such as hypertension, atherosclerosis, and hypercholesterolemia...
  15. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    ..and dilation and has effects on platelet aggregation, with pathologies including hypertension and other vascular diseases. Autoimmune mechanisms trigger NO production by iNOS, leading to apoptosis of pancreatic beta cells in both ..
  16. Regulation and Function of the Matricellular Protein CCN1 in Ischemic Retinopathy
    Brahim Chaqour; Fiscal Year: 2013
    ..and pathological processes will have important therapeutic implications for the treatment of human retinal vascular diseases. The long term goal of our laboratory is to uncover the in vivo functions of the matricellular protein CCN1, ..
  17. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..It is also well known that persons of AD have an increased prevalence of systemic and cerebral vascular diseases. Given these findings, this study is designed to investigate if abnormal ocular perfusion pressure and blood ..
  18. Nox4 and Vascular Homeostasis
    John F Keaney; Fiscal Year: 2013
    ..In patients with vascular diseases such as hypertension and atherosclerosis, NO bioactivity is impaired predisposing these patients to vascular ..
  19. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    John H Streiff; Fiscal Year: 2010
    ..are routinely involved in renal hypertensive disorders, chronic kidney diseases with hypertension, and vascular diseases. Cystic fibrosis is a disease of children and young adults that causes mortality due to its progressive and ..
  20. ACTIVATION OF XENOGENEIC ENDOTHELIUM TO RESIST INJURY
    Agustin P Dalmasso; Fiscal Year: 2010
    ..This will also provide knowledge for new treatments for vascular diseases, including ischemia and atherosclerosis.
  21. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    Erik Schwiebert; Fiscal Year: 2009
    ..are routinely involved in renal hypertensive disorders, chronic kidney diseases with hypertension, and vascular diseases. Cystic fibrosis is a disease of children and young adults that causes mortality due to its progressive and ..
  22. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..processes and in a wide variety of pathological conditions of human diseases, including ischemic vascular diseases, atherosclerosis, tumor growth and metastasis, diabetic retinopathy, age-related macular degeneration, and ..
  23. NFATs and Vascular Injury
    Gadiparthi N Rao; Fiscal Year: 2013
    ..monocyte chemoattractant protein-1 (MCP-1), a potent chemokine that appears to play an important role in vascular diseases, possesses the capacity to activate NFATs in human aortic smooth muscle cells (HASMCs)...
  24. PAI-1 and Vitronectin in Failure of Coronary Revascularization
    William P Fay; Fiscal Year: 2013
    ..coronary intervention (PCI) and are central processes in the development of atherosclerosis and other human vascular diseases. Available studies suggest that PAI-1 and VN can either promote or inhibit VSMC migration and intimal ..
  25. Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries
    Sean M Wilson; Fiscal Year: 2013
    ..RyR channelopathies actively participate in the pathogenesis of neuronal, skeletal muscle, cardiac, and vascular diseases and yet their role in fetal programming of pulmonary vascular disease is unknown...
  26. Dietary control of angiogenesis in retinopathy models
    Lois Smith; Fiscal Year: 2013
    ..Lipid biochemistry has been inadequately explored in this area although dyslipidemia is closely associated with progression of ocular vascular diseases. Dietary lipids may be safe, potent, and inexpensive treatment options.
  27. Effect of White Matter Disease on Gait and Balance in Cerebral Amyloid Angiopathy
    Anand Viswanathan; Fiscal Year: 2013
    ..It is the applicant's career goal to obtain expertise in the clinical and radiologic investigation of vascular diseases of white matter...
  28. The control of retinal vascular development by Norrin and Frizzled4
    Jeremy Nathans; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinal vascular diseases are major causes of vision loss in the United States and around the world...
  29. EICOSANOIDS AND VASCULAR WALL REMODELING
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Such knowledge would be useful in the development of therapeutic drugs against vascular diseases such as atherosclerosis.
  30. Mechanisms mediating circadian oscillations of leukocyte migration
    Paul S Frenette; Fiscal Year: 2012
    ..Circadian manifestations of vascular diseases, including ischemic vasculopathies and sickle cell disease, have been well documented...
  31. Regulation and Function of AKAP12A in the Vessel Wall
    Joseph M Miano; Fiscal Year: 2013
    ..SRF) and the potent SRF coactivator, Myocardin (MYOCD) and its down-regulation in experimental and clinical vascular diseases;another isoform (Akap12b) is low in VSMC in vivo, but increases upon cell culture...
  32. Molecular Characterization of NoxA1 in VSMC NADPH Oxidase Activation
    Marschall S Runge; Fiscal Year: 2013
    ..In particular, dysregulation of Nox1 NADPH oxidase has been implicated in many vascular diseases including atherosclerosis, aortic dissection, hypertension and stroke...
  33. The Fat1 Cadherin in Atherosclerotic Vascular Disease
    NICHOLAS E SIBINGA; Fiscal Year: 2013
    ..by applicant): Vascular remodeling is a central process in the pathogenesis of clinically important vascular diseases such as atherosclerosis, restenosis, coronary artery bypass graft failure, and arteriosclerosis that occurs ..
  34. Mechanisms for Arsenic-Induced Vascular Disease
    Aaron Barchowsky; Fiscal Year: 2012
    ..In general, the pathogenesis of As III induced vascular diseases has been understudied, in part, due to a lack of relevant animal models sensitive to chronic low dose As III ..
  35. Novel Approaches in Treatment of Vascular Injury Following Balloon Angioplasty
    YEVGENIYA EMRE KOSHMAN; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Vascular diseases affect millions of Americans and are the leading cause of death and disability in the United States...
  36. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    ..by applicant): Although thoracic aortic aneurysm and dissection (TAAD) are not as common as some forms of vascular diseases, e.g. coronary artery disease, it is a clinically insidious disease with high fatality...
  37. CELL BIOLOGIC APPROACHES TO DIABETES RESEARCH
    Marco Colonna; Fiscal Year: 2013
    ..8) diabetic neuropathy, 9) glucose transporters &Type 2 diabetes , 10) lipid synthesis, metabolism &vascular diseases in diabetes, 11) obesity, diabetes &nutrition, 12) diabetes-induced pregnancy loss &malformations...
  38. Role of miR-145 in Vascular Smooth Muscle Cell BiologyRole of
    Chunxiang Zhang; Fiscal Year: 2013
    ..migration and proliferation, plays a critical role in the pathogenesis of a variety of proliferative vascular diseases such as atherosclerosis and restenosis...
  39. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2012
    ..by applicant): Lung transplantation (LTx) is a treatment option for end-stage pulmonary parenchymal and vascular diseases. However, long-term survival of the lung allograft is limited by the development of bronchiolitis obliterans ..
  40. Atherogenic Mechanisms Associated with Hyperhomocysteinemia
    Hong Wang; Fiscal Year: 2013
    ..Collectively, these findings implicate HHcy in the etiology of inflammatory vascular diseases. The hypothesis to be tested in this proposal is that HHcy accelerates atherosclerosis by activating ..
  41. Arterial Remodeling in Chronic Liver Diseases
    Yasuko Iwakiri; Fiscal Year: 2013
    ..Furthermore, it is likely that our findings will be relevant to other vascular diseases. PUBLIC HEALTH RELEVANCE: Life-threatening complications of liver disease, such as variceal hemorrhage with ..
  42. Morphogenesis of the pulmonary artery smooth muscle layer
    Daniel Greif; Fiscal Year: 2012
    ..and motility of vascular smooth muscle cells (VSMCs) are key elements in the pathogenesis of many vascular diseases. Thus, a detailed understanding of the development of the VSMC layer of normal blood vessels promises to ..
  43. Molecular Imaging of Protease Activation in Aneurysm
    Mehran M Sadeghi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vascular diseases, including aortic aneurysm, are major causes of morbidity and mortality in the US...
  44. In Utero Programming of Adult Vascular Function
    Monica Longo; Fiscal Year: 2010
    ..environment and adult diseases may be confounded by a genetic predisposition toward specific diseases (eg, vascular diseases) as the maternal genes that are transmitted o the fetus may also set the uterine environment...
  45. Human tissue-engineered blood vessels using induced pluripotent stem cells
    Yibing Qyang; Fiscal Year: 2013
    ..human body including functional vascular SMCs, providing ideal cell sources for generating TEBVs to treat vascular diseases. We recently established hiPSC lines and derived unlimited amounts of highly homogeneous functional vascular ..
  46. The Role of Ets-1 in Vascular Inflammation
    J PETER PETER OETTGEN; Fiscal Year: 2011
    ..of vascular inflammation and is therefore required for mediating inflammatory responses in a number of vascular diseases. The goals of these studies are to: 1) Characterize how Ets-1 is regulated by Ang II at the transcriptional, ..
  47. Expression of PKG in Vascular Smooth Muscle Cells
    Thomas M Lincoln; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atherosclerosis and other vascular diseases account for more deaths in the U.S. than any other cause...
  48. Mechanisms Mediating Age-Related Impairments in Microvascular Collaterals
    STEVEN JEFFREY MILLER; Fiscal Year: 2012
    ..a rapidly increasing aged population will result in markedly increased incidences of all types of occlusive vascular diseases. The normal compensatory response to an arterial occlusion is the enlargement of preexisting collateral ..
  49. Insulin Resistance Intervention after Stroke (IRIS) Trial
    Walter N Kernan; Fiscal Year: 2013
    ..Insulin resistance is a common, novel risk factor for stroke and other vascular diseases. It is also, along with failed pancreatic secretion of insulin, one of the 2 main causes of diabetes...
  50. PROGERIN ENDOTHELIAL DYSFUNCTION AND VASCULAR DISEASE
    Michael A Gimbrone; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vascular diseases, in particular atherosclerosis and its complications (e.g...
  51. Vascular Endothelial Activation in Sleep Apnea
    Sanja Jelic; Fiscal Year: 2013
    ..of endothelial activation in OSA and may allow (1) early identification of OSA patients who are at risk for vascular diseases and (2) provide basis for functional studies that may lead to the development of novel therapeutic ..
  52. Identification and study of the vascular disease gene at 9p21.3
    Thomas Quertermous; Fiscal Year: 2013
    ..In addition to CHD, variants at C9CAR have been associated with other vascular diseases, including abdominal aortic aneurysm, stroke, and peripheral vascular disease...
  53. Mutations in Smooth Muscle Contractile Proteins: Pathways to Vascular Diseases
    Dianna M Milewicz; Fiscal Year: 2013
    ..with the kinase that controls SMC contraction, myosin light chain kinase (MYLK), predispose individuals to vascular diseases, including thoracic aortic aneurysms and aortic dissections and occlusive vascular diseases, such as early ..
  54. Regulation of Protease-activated Receptor-1 Signaling
    JoAnn Trejo; Fiscal Year: 2012
    ..ability to manipulate it, may provide new strategies for the prevention and treatment of thrombin-related vascular diseases. Protease- activated receptors (PARs) are G-protein coupled receptors (GPCRs) that mediate most, if not all, ..
  55. TRAINING GRANT IN MECHANISMS OF VASCULAR DISEASE
    Paul E Bock; Fiscal Year: 2013
    ..The areas are: (1) Microbial Vascular Diseases;(2) Atherosclerosis, Obesity, and Hypertension;(3) Cardiovascular Development and Vasculogenesis;(4) ..
  56. Novel Associations of Anxiety, Depression and Telomeres across Mid- and Late-Life
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2013
    ..Further, by exploring mediation by medical conditions, such as vascular diseases and risk factors, we can elucidate pathways - addressing whether any identified telomere-mental health ..
  57. PGE2 receptors: therapeutic targets in occlusive and aneurysmal vascular diseases
    Domenick J Falcone; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Complications of atherosclerotic and aneurysmal vascular diseases remain a major cause of morbidity and mortality in the United States...
  58. The EphB4 Receptor as a Novel Breast Cancer Target
    Elena B Pasquale; Fiscal Year: 2010
    ..The EphB4-targeting molecules that we propose to develop will also be useful for therapies against vascular diseases involving EphB4 and ephrin-B2...
  59. Novel Regulators of Vascular Disease
    Paul W Sanders; Fiscal Year: 2013
    ..diseases such as systolic hypertension, cerebrovascular, cardiovascular, renovascular, and peripheral vascular diseases - all represent a significant burden affecting the Veteran population...
  60. Signaling Mechanisms in Myogenic Tone of Skeletal Muscle Arterioles: Role of BKCa
    Michael A Hill; Fiscal Year: 2012
    ..impact on design and utilization of channel modulators developed as therapeutic measures for treatment of vascular diseases. PUBLIC HEALTH RELEVANCE: This study will improve our knowledge of how small arteries can vary their ..
  61. Aldosterone impairs endothelin B-dependent synthesis of nitric oxide to promote p
    BRADLEY MARON; Fiscal Year: 2013
    ..These studies aim to identify novel treatment targets for PAH and other vascular diseases with similar pathobiology.
  62. Transcriptional Regulation and Vascular Protection by IL-10
    Anthony A Cuneo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The development of multiple vascular diseases is inflammatory in nature...
  63. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..damage has been implicated in the pathogenesis of numerous degenerative diseases including coronary vascular diseases (CVD)...
  64. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..While there are well known associated disease states with primary PHT (collagen vascular diseases, anorexigen exposure, idiopathic) and secondary PHT (COPD, congenital heart disease) the initial injury ..
  65. POLYAMINES AND MONOCROTALINE PNEUMOTOXICITY (AHR-F1)
    JACK OLSON; Fiscal Year: 1999
    ..A feature common to all forms of pulmonary hypertension and vascular diseases in the initial insult/injury that leads to pathogenic progressive vascular remodeling...
  66. INTRACELLULAR TRAFFICKING OF TROPOELASTIN
    Frederick Grinnell; Fiscal Year: 2002
    ..Increasing evidence suggests that in virtually all vascular diseases, some aspect of elastic fiber assembly or structure is affected...
  67. XANTHINE OXIDASE MODULATION OF CELL OXIDANT PRODUCTION
    Margaret Tarpey; Fiscal Year: 2004
    ..of oxidants contribute to defective vascular function and are implicated in the pathogenesis of diverse vascular diseases. However, the tissue sources of enhanced vascular cell oxidant production and the sites of oxidant action ..
  68. Cytomegalovirus infection of blood vessels
    Fenyong Liu; Fiscal Year: 2005
    ..Moreover, HCMV has also been implicated as a possible etiologic factor in the pathogenesis of vascular diseases, including atherosclerosis, arterial restenosis following angioplasty, and solid organ transplant vascular ..
  69. R-HOMOCYSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 1999
    ..Even moderate homocysteinemia is now regarded as a riskfactor for cardiac and vascular diseases. In order to meet the need for a simple, high through-put assay for homocysteine that can utilize modern ..