- Vascular calcification mechanisms
Cecilia M Giachelli
Bioengineering Department, Box 351720, University of Washington, Okanogan Lane, Bagley Hall, Seattle, WA 98195, USA
J Am Soc Nephrol 15:2959-64. 2004
..Whether or not vascular calcification can be reversed is not yet known, but exciting new studies suggest that this may be possible in the future...
- Role of microRNAs in vascular diseases, inflammation, and angiogenesis
Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Cardiovasc Res 79:581-8. 2008
..Thus, the identification of miRNAs and their respective targets may offer new therapeutic strategies to treat vascular diseases such as atherosclerosis, to improve neovascularization after ischaemia, or to prevent tumour progression.
- Oxidative stress and microRNAs in vascular diseases
Istituto Dermopatico del Immacolata IRCCS, Vascular Pathology Laboratory, Via dei Monti di Creta 104, Rome 00167, Italy
Int J Mol Sci 14:17319-46. 2013
Oxidative stress has been demonstrated to play a causal role in different vascular diseases, such as hypertension, diabetic vasculopathy, hypercholesterolemia and atherosclerosis...
- BMP signaling in vascular diseases
Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
FEBS Lett 586:1993-2002. 2012
..and mice showed that perturbations in BMP signaling lead to various diseases, such as skeletal diseases, vascular diseases and cancer...
- Mechanisms underlying endothelial dysfunction in diabetes mellitus
Universitatskrankenhaus Eppendorf, Germany
Circ Res 88:E14-22. 2001
..The full text of this article is available at http://www.circresaha.org...
- Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
Lorenz C Hofbauer
Department of Gastroenterology, Philipps University, Marburg, Germany
JAMA 292:490-5. 2004
..Moreover, alterations of the OPG/RANKL/RANK system have been implicated in vascular diseases. RANKL blockade (using OPG or RANK fusion proteins or RANKL antibodies) has prevented bone loss caused by ..
- Endoglin in angiogenesis and vascular diseases
Peter Ten Dijke
Department of Molecular Cell Biology, Leiden University Medical Center, Building 2, Room R 02 022, Postzone S 1 P, Postbus 9600, 2300 RC, Leiden, The Netherlands
Angiogenesis 11:79-89. 2008
..These exciting advances provide opportunities for the development of new therapies for diseases with vascular abnormalities...
- Periodontal bacteremia and various vascular diseases
Tsukuba Vascular Center and Buerger Disease Research Institute, Tatsuzawa, Moriya city, Japan
J Periodontal Res 44:689-94. 2009
..Serum titer levels of each bacterium are now available and have shown a significant relationship between severity and individual differences...
- Differentiation of multipotent vascular stem cells contributes to vascular diseases
Department of Bioengineering, University of California, Berkeley, California 94720, USA
Nat Commun 3:875. 2012
..These findings support a new hypothesis that the differentiation of multipotent vascular stem cells, rather than the de-differentiation of smooth muscle cells, contributes to vascular remodelling and diseases...
- Matrix metalloproteinase inhibition therapy for vascular diseases
Andrew C Newby
Bristol Heart Institute, University of Bristol, UK
Vascul Pharmacol 56:232-44. 2012
..This review documents the established actions of MMPs and their inhibitors in vascular pathologies and considers the prospects for translating these findings into new treatments...
- RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases
Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, EA3822, Universite de Nantes, Nantes Atlantique Universites, F 44035, Nantes, France
Cell Mol Life Sci 64:2334-50. 2007
..interactions and activities as well as the current evidence for their participation in osteoimmunology and vascular diseases. In fine, the targeting of the OPG/RANK/RANKL axis as novel therapeutic approaches will be discussed.
- Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
Rega Institute for Medical Research, Catholic University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
Nat Rev Drug Discov 6:480-98. 2007
..that the use of selective inhibitors might lead to new therapies for acute and chronic inflammatory and vascular diseases. In this Review, we compare the major classes of MMP inhibitors and advocate that future drug discovery ..
- The association between mood and anxiety disorders with vascular diseases and risk factors in a nationally representative sample
Jess G Fiedorowicz
Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
J Psychosom Res 70:145-54. 2011
To investigate the association between mood and anxiety disorders and vascular diseases after controlling for vascular disease risk factors.
- The role of inflammation in vascular diseases
G W Sullivan
University of Virginia, Department of Medicine, Health Sciences Center, Charlottesville 22908, USA
J Leukoc Biol 67:591-602. 2000
..This review focuses on the causes, the inflammatory processes involved, and possible strategies for decreasing vascular disease through regulation of the inflammatory response...
- Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases
Department of Biochemistry, Ohio University, Athens, OH 45701, USA
Circulation 109:2511-7. 2004
..We hypothesized that the differences in endothelial NO/O2-/ONOO- metabolism may highlight the potential predisposition to endothelial dysfunction and cardiovascular complications prevalent in blacks...
- Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan
Shu Li Wang
Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Kaohsiung, Taiwan
Environ Health Perspect 111:155-59. 2003
..However, the prevalence of diabetes and related vascular diseases in the entire southwestern arseniasis-endemic and nonendemic areas remains to be elucidated...
- The role of information in supporting self-care in vascular conditions: a conceptual and empirical review
NIHR Collaboration for Leadership in Applied Health Research CLARHC for Greater Manchester, Health Sciences Research Group, The University of Manchester, Manchester, UK
Health Soc Care Community 19:449-59. 2011
..g. tailored information, use of narratives and user generated content). Developing a framework for the effective use of information needs to take account the full range of the factors identified...
- Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease
Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy
Cytokine 63:92-6. 2013
..6; p=0.01), while showing a negative correlation with RI (R=-0.5; p=0.03). The potential implications of our findings for the pathophysiology of CVD are discussed...
- VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection)
Sino German Laboratory for Molecular Medicine, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College and National Genome Center, Beijing, People s Republic of China
Circulation 113:1615-21. 2006
..We hypothesized that VKORC1-dependent effects on the coagulation cascade and atherosclerosis would contribute to susceptibility for vascular diseases.
- Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, University of Naples, Italy
Arch Pharm Res 32:1103-8. 2009
- Angiotensin II-mediated development of vascular diseases
Department of Medicine, and the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
Trends Cardiovasc Med 14:117-20. 2004
..The definition of the cellular mechanisms by which Ang II promotes these vascular pathologies may provide new therapeutic strategies...
- Vascular abnormalities in patients with neurofibromatosis syndrome type I: clinical spectrum, management, and results
Gustavo S Oderich
Division of Vascular Surgery, Mayo Clinic, Gonda Vascular Center, Rochester, MN 55905, USA
J Vasc Surg 46:475-484. 2007
..Vascular abnormalities are a well-recognized manifestation of NF-I. The purpose of this study is to review the spectrum, management, and clinical outcome of patients with vascular abnormalities and NF-I...
- Predictors of primary care referrals to a vascular disease prevention lifestyle program among participants in a cluster randomised trial
Megan E Passey
University of Sydney, Lismore, Australia
BMC Health Serv Res 12:234. 2012
..This paper examines patient and practice predictors of referral to a lifestyle modification program (LMP) offered as part of a cluster randomised controlled trial (RCT) of prevention of vascular disease in primary care...
- The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting
Department of Pediatrics, First Hospital of Peking University, Xi An Men Street No 1, 100034, Beijing, P R China
Heart Vessels 19:81-8. 2004
..Nitric oxide, as a modifying factor, might be involved in the regulation of pulmonary vascular structural remodeling...
- Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases
D J Beech
Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U K
Biochem Soc Trans 35:890-4. 2007
..is the VSMC (vascular smooth-muscle cell), a fascinating cell that contributes significantly to occlusive vascular diseases by virtue of its ability to 'modulate' to a cell that no longer contracts and arranges radially in the ..
- Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
Gerard M London
Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
Curr Opin Nephrol Hypertens 14:525-31. 2005
..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
- Homocysteine lowering with folic acid and B vitamins in vascular disease
Population Health Research Institute, Hamilton General Hospital, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont
N Engl J Med 354:1567-77. 2006
..Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease...
- Mechanisms of oxidative stress and vascular dysfunction
Z S Nedeljkovic
Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Postgrad Med J 79:195-199; quiz 198-200. 2003
..In this review, the role of oxidative stress in mechanisms of vascular dysfunction is discussed, and potential antioxidant strategies are reviewed...
- RAGE, vascular tone and vascular disease
David G S Farmer
Integrative and Systems Biology, Faculty of Biological and Life Sciences, West Medical Building, University of Glasgow, G12 UQQ, United Kingdom
Pharmacol Ther 124:185-94. 2009
..In addition to atherosclerosis and vascular diseases associated with diabetes, recent data from studies in transgenic mice overexpressing the RAGE ligand S100A4/..
- Magnetic resonance imaging permits in vivo monitoring of catheter-based vascular gene delivery
Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA
Circulation 104:1588-90. 2001
..CONCLUSIONS: We present a technical development that uses high-resolution MR imaging as an in vivo imaging tool to monitor catheter-based vascular gene delivery...
- Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases
Catherine C Neto
Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA
Mol Nutr Food Res 51:652-64. 2007
..have the potential ability to limit the development and severity of certain cancers and vascular diseases including atherosclerosis, ischemic stroke, and neurodegenerative diseases of aging...
- Mortality in neurofibromatosis 1: an analysis using U.S. death certificates
S A Rasmussen
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Am J Hum Genet 68:1110-8. 2001
- Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis
Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
J Clin Endocrinol Metab 89:4104-12. 2004
- Arterial stiffness, vascular disease, and risk of cardiovascular events
Jay N Cohn
Circulation 113:601-3. 2006
- Vascular calcification in chronic kidney disease
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
J Bone Miner Metab 24:176-81. 2006
..These findings suggest that the balance of inducers, such as phosphate, and inhibitors, such as MGP, fetuin-A, and others, are likely to control whether or not calcification occurs under pathological conditions...
- Vascular calcifications: pathogenesis, management, and impact on clinical outcomes
Jorge B Cannata-Andia
Bone and Mineral Research Unit, Instituto Reina Sofia de Investigacion, Hospital Universitario Central de Asturias, Universidad de Oviedo, Julian Claveria s n, Oviedo 33006, Spain
J Am Soc Nephrol 17:S267-73. 2006
..Despite that new strategies may improve the management of vascular diseases and specifically have a positive impact on the high prevalence of vascular calcifications, still the best ..
- Molecular strategies to treat vascular diseases: circulating vascular progenitor cell as a potential target for prophylactic treatment of atherosclerosis
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo and PRESTO, Japan Science and Technology Agency, Kawaguchi
Circ J 67:983-91. 2003
..the recent findings on circulating vascular precursors and describes the potential therapeutic strategies for vascular diseases, targeting mobilization, homing, differentiation and proliferation of circulating progenitor cells.
- CD40 ligand: a neo-inflammatory molecule in vascular diseases
Ghada S Hassan
Laboratoire d Immunologie Cellulaire et Moléculaire, Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Montréal QC H2X 1P1, Canada
Immunobiology 217:521-32. 2012
..In addition, the CD40L system was demonstrated a major player in the pathology of vascular diseases, such as atherosclerosis and restenosis...
- Validity for use in research on vascular diseases of the SIDIAP (Information System for the Development of Research in Primary Care): the EMMA study
Unidad de Investigación en Atención Primaria de Girona, IDIAP Jordi Gol, Institut Catala de la Salut, Girona, Espana
Rev Esp Cardiol (Engl Ed) 65:29-37. 2012
..We sought to analyze the validity of the data used in the EMMA study based on data from the Information System for the Development of Research in Primary Care...
- Current status on plasma biomarkers for acute mesenteric ischemia
Vascular Center, Skane University Hospital, Malmo, Sweden
J Thromb Thrombolysis 33:355-61. 2012
..None of the proposed plasma-derived tests for acute mesenteric ischemia has as yet entered routine clinical practice. The proposed biomarkers need to be evaluated in a prospective clinical research project in patients with acute abdomen...
- Transfemoral aortic valve implantation new criteria to predict vascular complications
Institut Cardiovasculaire Paris Sud, Massy, France
JACC Cardiovasc Interv 4:851-8. 2011
..This study sought to evaluate the incidence, impact, and predictors of vascular complications in transcatheter aortic valve implantation (TAVI)...
- Initial imaging recommendations for Vasovist angiography
EPIX Pharmaceuticals, 161 First Street Cambridge, MA 02142, USA
Eur Radiol 16:B15-23. 2006
..Preliminary technical recommendations for the optimization of contrast-enhanced MRA with Vasovist can be deducted from current clinical trial experience in various vessel beds...
- Thiol compounds metabolism in mice, rats and humans: comparative study and potential explanation of rodents protection against vascular diseases
Assistance Publique Hopitaux de Paris, Service de Biochimie, Hopital Europeen Georges Pompidou, Paris, France
Clin Chim Acta 372:140-6. 2006
..We investigated whether species-specific differences in thiols metabolism may explain the respective sensitivity of rodents and humans to hyperhomocysteinemia...
- Morbidity and mortality after bowel resection for acute mesenteric ischemia
Prateek K Gupta
Department of Surgery, Creighton University, Omaha, NE 68131, USA
Surgery 150:779-87. 2011
- Roles of transglutaminases in cardiac and vascular diseases
David C Sane
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1045, USA
Front Biosci 12:2530-45. 2007
..In this review, we summarize the cardiovascular biology of two members of the family of transglutaminases, Factor XIII and TG2...
- Telmisartan improves vascular function independently of metabolic and antihypertensive effects in hypertensive subjects with impaired glucose tolerance
Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Austria
Int J Cardiol 139:289-96. 2010
..The aim of the present study was to compare vascular effects of telmisartan and losartan in relation to their metabolic and antihypertensive effects in hypertensive patients with IGT...
- Validation of the murine aortic arch as a model to study human vascular diseases
Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
J Anat 216:563-71. 2010
..thoracic aorta and its main branches are widely studied to gain more insight into the pathogenesis of human vascular diseases, detailed anatomical data on the murine aorta are sparse...
- A cluster randomised controlled trial of vascular risk factor management in general practice
Mark F Harris
Centre for Primary Health Care and Equity, University of New South Wales, Sydney, NSW, Australia
Med J Aust 197:387-93. 2012
..To evaluate the impact of a lifestyle intervention in Australian general practice to reduce the risk of vascular disease...
- SIRT1 as a novel potential treatment target for vascular aging and age-related vascular diseases
State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, New Building 507, Beijing, 100005, People s Republic of China
Curr Mol Med 13:155-64. 2013
Aging is one of the greatest risk factors in vascular diseases (VDs)...
- A study on 107 patients with acute mesenteric ischemia over 30 years
Department of Surgery, Karadeniz Technical University, Farabi Hospital, 61080 Trabzon, Turkey
Int J Surg 10:510-3. 2012
..A high index of suspicion with prompt diagnostic evaluation with CT angiography may reduce time prior to surgical intervention which may lead to improved patient survival...
- Platelets as cellular effectors of inflammation in vascular diseases
Matthew T Rondina
Department of Medicine and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
Circ Res 112:1506-19. 2013
..Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.
- Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
Blood 111:4559-70. 2008
..These findings suggest that autoantibodies to RLIP76 play a pathogenetic role in immune-mediated vascular diseases and represent a valuable peripheral blood bioindicator of atherosclerosis and immune-mediated vascular ..
- Percutaneous aortic valve replacement: vascular outcomes with a fully percutaneous procedure
Department of Cardiology, St Paul s Hospital, University of British Columbia, Vancouver, Canada
J Am Coll Cardiol 59:113-8. 2012
..The aim of this study was to evaluate vascular complications in a consecutive patient population undergoing transfemoral percutaneous aortic valve replacement (PAVR) applying current Valve Academic Research Consortium definitions...
- Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy
Arthritis Center, Boston University Medical Center, Boston, MA 02118, USA
Am J Pathol 176:1983-98. 2010
..Importantly, vascular characteristics of Fli1 CKO mice are recapitulated by SSc microvasculature. Thus, persistently reduced levels of Fli1 in endothelial cells may play a critical role in the development of SSc vasculopathy...
- Risk of vascular events in emergency department patients discharged home with diagnosis of dizziness or vertigo
Anthony S Kim
Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
Ann Emerg Med 57:34-41. 2011
..Given the concern that important diagnoses could be missed, we measure the incidence of subsequent major vascular events in patients after discharge home...
- Uric acid, hyperuricemia and vascular diseases
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
Front Biosci (Landmark Ed) 17:656-69. 2012
- Arterial wall-determined risk factors to vascular diseases: a nonhuman primate model
Xing Li Wang
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Cell Biochem Biophys 40:371-88. 2004
..In the current review, we discuss the importance of arterial wall factors in vascular diseases and present a baboon model for practical studies of arterial wall factors and their interaction with ..
- Retinoids: pleiotropic agents of therapy for vascular diseases?
Jeffrey W Streb
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Curr Drug Targets Cardiovasc Haematol Disord 3:31-57. 2003
..Retinoid-response genes, therefore, represent promising targets of therapy for the refined treatment of vascular diseases. The purpose of this review is to summarize the emerging importance of retinoids in the control of vascular ..
- Venous stenosis in a pig arteriovenous fistula model--anatomy, mechanisms and cellular phenotypes
Division of Nephrology, University of Cincinnati, Albert Sabin Way, Cincinnati, OH 45267 0585, USA
Nephrol Dial Transplant 23:525-33. 2008
..The aim of this study was to develop and validate a pig model of AV fistula stenosis and then use it to dissect out the mechanisms responsible for this lesion...
- Associations between vascular co-morbidities and depression in insulin-naive diabetes patients: the DIAZOB Primary Care Diabetes study
Center of Research on Psychology in Somatic Diseases, Department of Medical Psychology, Tilburg University, The Netherlands
Diabetologia 52:2056-63. 2009
..The aim of the study was to determine the prevalence of depression in insulin-naive diabetes patients and to investigate the associations between different forms of vascular co-morbidity and depression...
- Postpartum angiopathy with reversible posterior leukoencephalopathy
Aneesh B Singhal
Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
Arch Neurol 61:411-6. 2004
..The pathophysiological features of RPLS are related to small-vessel dysfunction and breakdown of the blood-brain barrier...
- Vascular complications of transfemoral aortic valve implantation with the Edwards SAPIEN prosthesis: incidence and impact on outcome
Department of Cardiology, Bichat Claude Bernard Hospital, Paris, France
EuroIntervention 5:666-72. 2010
..Vascular complications remain the main limitation of transfemoral aortic valve implantation. Based on a single-centre experience, we aim to detail the type, management and impact of those vascular complications...
- Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyri
Laboratorio de Radicales Libres y Química Computacional IQOG, CSIC, C Juan de la Cierva 3, 28006 Madrid, Spain
Bioorg Med Chem 18:5861-72. 2010
..can be considered as attractive multipotent therapeutic molecules on two key pharmacological receptors playing key roles in the progress of Alzheimer, that is, cholinergic dysfunction and oxidative stress, and neuronal vascular diseases.
- Acute exacerbation of interstitial pneumonia associated with collagen vascular diseases
2nd Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
Respir Med 103:846-53. 2009
..However, the incidence of AE in CVD-IP and its clinical characteristics remain to be fully determined. This study was conducted to elucidate cumulative incidence of AE in CVD-IP and its clinical features...
- Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases
Francisco R M Laurindo
Vascular Biology Laboratory, Heart Institute InCor, University of Sao Paulo School of Medicine, Brazil
Antioxid Redox Signal 10:1101-13. 2008
..These data may clarify an integrative view of oxidase activation in disease conditions, including stress responses...
- The microenvironment can shift erythrocytes from a friendly to a harmful behavior: pathogenetic implications for vascular diseases
Department of Cell Biology and Neurosciences, Istituto Superiore Sanita, Rome, Italy
Cardiovasc Res 75:21-8. 2007
..In line with recent data from the literature, erythrocytes can be proposed as bioindicators of progression in chronic or acute diseases characterized, as a hallmark, by oxidative alterations...
- Vascular Ehlers-Danlos syndrome
Dominique P Germain
Clinical Genetics Unit, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015, Paris, France
Ann Genet 47:1-9. 2004
- Molecular basis for arsenic-induced alteration in nitric oxide production and oxidative stress: implication of endothelial dysfunction
Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
Toxicol Appl Pharmacol 198:450-7. 2004
..studies have suggested that prolonged exposure of humans to arsenic in drinking water is associated with vascular diseases. The exact mechanism of how this occurs currently unknown...
- Graft vascular disease: immune response meets the vessel wall
Richard N Mitchell
Department of Pathology, Health Sciences and Technology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Annu Rev Pathol 4:19-47. 2009
..Because GVD shares many features with more common vascular pathologies, insights gleaned from our understanding of allograft vasculopathy may well impact our treatment for "traditional" atherosclerosis or restenosis lesions...
- Nitric oxide, oxidative excess, and vascular complications of diabetes mellitus
Dierk H Endemann
Clinical Research Institute of Montreal, 110 Pine Avenue W, Montreal, Quebec, Canada H2W 1R7
Curr Hypertens Rep 6:85-9. 2004
..Advances in understanding the pathophysiologic mechanisms leading to vascular damage in diabetes will result in discovery of new therapeutic targets, which should help reduce cardiovascular risk in these patients...
- Algorithm for using a long-pulsed Nd:YAG laser in the treatment of deep cutaneous vascular lesions
University of Alberta, Canada
Dermatol Surg 29:35-42. 2003
..New laser systems offer greater potential to treat these difficult lesions, but the lack of specific treatment guidelines has restricted consistent success...
- Analysis of risk factors for myocardial infarction and cardiac mortality after major vascular surgery
Department of General Anesthesiology, The Cleveland Clinic Foundation, OH 44195, USA
Anesthesiology 93:129-40. 2000
..Patients undergoing vascular surgical procedures are at high risk for perioperative myocardial infarction (PMI). This study was undertaken to identify predictors of PMI and in-hospital death in major vascular surgical patients...
- Vascular effects of photodynamic therapy
Institute of Physics and Biophysics, University of Salzburg, Austria
Anticancer Res 21:4271-7. 2001
..Successful application of PDT mainly for vessel occlusion and thrombosis in intimal hyperplasia, restenosis, atherosclerotic plaques, corneal and choroidal neovascularisation and port-wine stains is reported...
- Involvement of periodontopathic biofilm in vascular diseases
Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Mihama ku, Chiba, Japan
Oral Dis 10:5-12. 2004
..We focus on the relationships between periodontal disease-associated bacteria forming biofilms and vascular diseases including atherosclerosis and carotid coronary stenotic artery disease, and we discuss the direct and ..
- Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity
Jonathan C Choy
The iCAPTUR4E Centre UBC McDonald Research Laboratories, Department of Pathology and Laboratory Medicine, St Paul s Hospital Providence Health Care University of British Columbia, Vancouver, British Columbia, Canada
Mod Pathol 16:460-70. 2003
..These observations suggest that granzyme B-mediated apoptosis may contribute to the pathogenesis of these diseases...
- Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway
Cellular Biology Laboratory, Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, Avenida Albert Einstein, Sao Paulo, Brazil
Crit Care Med 32:818-25. 2004
- Proteinase-activated Receptor 2 (PAR2): a challenging new target for treatment of vascular diseases
John J McGuire
Cardiovascular Research Group, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
Curr Pharm Des 10:2769-78. 2004
Proteinase-activated Receptor 2 (PAR2) is a potential target for the design of drug treatments for vascular diseases. Its unique mechanism of activation by serine proteinases, questions regarding the identities of endogenous agonists and ..
- Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases
Department of Laboratory Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
Curr Pharm Des 12:575-87. 2006
..In this review, I will summarize recent findings on possible roles of Sph-1-P in vascular biology and its therapeutical implications...
- Pulmonary and vascular manifestations of Behcet disease: imaging findings
Department of Radiology, Ege University School of Medicine, Bornova, Izmir, Turkey
AJR Am J Roentgenol 194:W158-64. 2010
..CT is an important diagnostic imaging technique in the evaluation of patients with Behçet disease...
- Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction
Department of Internal Medicine, University of Turin, 10126 Turin, Italy
J Endocrinol Invest 31:499-504. 2008
..The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are all linked to cardiovascular disease...
- Vascular complications with transcatheter aortic valve implantation using the 18 Fr Medtronic CoreValve System: the Rotterdam experience
Nicolas M Van Mieghem
Department of Cardiology, Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands
EuroIntervention 5:673-9. 2010
..Access site complications, therefore, can be a concern. The aim of this study is to present the 30-day incidence of major and minor vascular complications in patients treated with the third generation 18 Fr Medtronic CoreValve System...
- Microparticles in vascular diseases
Françoise Dignat George
INSERM U 608, laboratoire d hématologie et d immunologie, Marseille, France
Thromb Res 122:S55-9. 2008
..In these clinical settings, the pharmacological modulation of MP level or activity provides challenging issues...
- Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow
Joseph E Brayden
Department of Pharmacology, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
Clin Exp Pharmacol Physiol 35:1116-20. 2008
..g. hypertension, stroke, vasospasm)...
- Arterial calcification in diabetes
Neal X Chen
Department of Medicine, Indiana University School of Medicine, 1001 West 10th Street, OPW 526, Indianapolis, IN 46202, USA
Curr Diab Rep 3:28-32. 2003
..Further understanding of the mechanism by which diabetes induces this complication is needed to design effective therapeutic strategies to intervene with this process...
- Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I
Mark A Creager
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
Circulation 108:1527-32. 2003
- Increased incidence of coronary atherosclerosis in type 2 diabetes mellitus: mechanisms and management
R Todd Hurst
Mayo Clinic, Scottsdale, Arizona 85259, USA
Ann Intern Med 139:824-34. 2003
..However, patients with diabetes benefit more from treatments that reduce coronary artery disease risk...
- Contribution of B cells and antibody to cardiac allograft vasculopathy
Department of Surgery, Atlantic Centre for Transplantation Research, Microbiology and Immunology and Pathology, Dalhousie University, Halifax, NS, Canada
Transplantation 88:470-7. 2009
..No studies have been conducted in the presence of a clinically relevant immunosuppressant. In our study, we use cyclosporin A, a calcineurin inhibitor...
- Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease
Department of Nephrology and Medicine, University of Melbourne, Austin Hospital, Australia
Semin Nephrol 25:39-42. 2005
..Experimental evidence suggests a complex but potentially direct causal role for uric acid in the pathogenesis of hypertension and atherosclerosis...
- Risk of elevated resting heart rate on the development of type 2 diabetes in patients with clinically manifest vascular diseases
Remy H H Bemelmans
Department of Vascular Medicine, Julius Center for Health Sciences and Primary Care Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
Eur J Endocrinol 166:717-25. 2012
..Resting heart rate (RHR) reflects sympathetic nerve activity. We investigated the effect of RHR on the incidence of type 2 diabetes mellitus (T2DM) in patients with clinically manifest vascular diseases.
- Determinants of coronary vascular calcification in patients with chronic kidney disease and end-stage renal disease: a systematic review
Peter A McCullough
Department of Medicine, Divisions of Cardiology, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA
J Nephrol 17:205-15. 2004
..Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are conditions associated with metabolic disorders related to soft tissue calcification...
- Vascular cell lines expressing SSAO/VAP-1: a new experimental tool to study its involvement in vascular diseases
Institut de Neurociències i Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
Biol Cell 103:543-57. 2011
..However, the study of this enzyme is difficult, owing to its loss of expression in cell cultures...
- Systematic appraisal of the management of the major vascular complications of pancreatitis
Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9RN, United Kingdom
Am J Surg 190:489-95. 2005
..This study is a systematic appraisal of the management of major vascular complications of pancreatitis conducted by collating individual patient-episode data from published literature...
- The role of sex on VARC outcomes following transcatheter aortic valve implantation with both Edwards SAPIEN™ and Medtronic CoreValve ReValving System® devices: the Milan registry
Gill Louise Buchanan
Interventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy
EuroIntervention 7:556-63. 2011
..To assess outcomes after transcatheter aortic valve implantation (TAVI) according to sex, with the two available valves and four recognised delivery approaches...
- Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
Gregory J Kato
Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
Blood 107:2279-85. 2006
..We propose that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy...
- Genetic determinants of obesity and related vascular diseases
Department of Neurology, Philipps University, Marburg Germany
Vitam Horm 91:29-48. 2013
Obesity is one of the major risk factors of vascular diseases, and its prevalence is increasing worldwide. In the past decade, progress has been made in the understanding of genetic determinants of obesity and obesity-associated diseases...
- Antibiotics for vascular diseases: a meta-analysis of randomized controlled trials
Kachi O Illoh
Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Atherosclerosis 179:403-12. 2005
Trials of antibiotic treatment of vascular diseases, in attempts to eradicate possible microbial initiators, have had mixed results...
- Low-dose, time-resolved, contrast-enhanced 3D MR angiography in cardiac and vascular diseases: correlation to high spatial resolution 3D contrast-enhanced MRA
M S Krishnam
Department of Radiological Sciences, University of California at Los Angeles, Los Angeles, CA 90095 7206, USA
Clin Radiol 63:744-55. 2008
..time-resolved, three-dimensional (3D) magnetic resonance (MR) angiography (TR-MRA) in the assessment of various cardiac and vascular diseases, and to compare the results with high-resolution contrast-enhanced MRA (CE-MRA).
- Migraine in women: the role of hormones and their impact on vascular diseases
Department of Neurology and Regional Referral Center for Headache Disorders, University of L Aquila, Piazzale Salvatore Tommasi, 1, 67100, L Aquila, Italy
J Headache Pain 13:177-89. 2012
..Consequently, in women suffering from migraine with aura caution should be deserved when prescribing combined oral contraceptives...
- Intermittent intravenous cyclophosphamide pulse therapy for the treatment of active interstitial lung disease associated with collagen vascular diseases
Department of Internal Medicine, Division of Rheumatology, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
Mod Rheumatol 17:131-6. 2007
The availability of intravenous cyclophosphamide (CYC) pulse therapy for collagen vascular diseases (CVD)-associated interstitial lung disease (ILD) has been indicated...
- Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA
Circulation 115:245-54. 2007
..We hypothesized that the inflammatory cytokine tumor necrosis factor-alpha (TNF) produces endothelial dysfunction in type 2 diabetes...
- Adipocytokines - novel link between inflammation and vascular function?
T J Guzik
Department of Internal Medicine, Jagiellonian University School of Medicine, Krakow, Poland
J Physiol Pharmacol 57:505-28. 2006
..Moreover future treatments of metabolic system associated disorders should focus on the regulation of adipocytokines and their modes of action...