hyperemia

Summary

Summary: The presence of an increased amount of blood in a part or organ. (Stedman, 25th ed)

Top Publications

  1. ncbi Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites
    D R Harder
    Cardiovascular Research Center and Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Stroke 29:229-34. 1998
  2. ncbi Reactive hyperemia and cardiovascular risk
    Andrew Philpott
    Arterioscler Thromb Vasc Biol 27:2065-7. 2007
  3. ncbi Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
    Jeffrey T Kuvin
    Department of Medicine, Division of Cardiology, Tufts New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 146:168-74. 2003
  4. ncbi Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
    Piero O Bonetti
    Center for Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 44:2137-41. 2004
  5. pmc Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study
    Naomi M Hamburg
    Cardiology Section, Whitaker Cardiovascular Institute, School of Medicine, Boston University, Boston, Mass 01702, USA
    Circulation 117:2467-74. 2008
  6. ncbi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
  7. ncbi Role of nitric oxide in the regulation of digital pulse volume amplitude in humans
    Anju Nohria
    Cardiovascular Div, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Appl Physiol (1985) 101:545-8. 2006
  8. ncbi Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 115:2390-7. 2007
  9. ncbi Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease
    Piero O Bonetti
    Center for Coronary Physiology and Imaging and the Cardiac Catheterization Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Am Coll Cardiol 41:1761-8. 2003
  10. pmc The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study
    Edward V R DiBella
    UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, USA
    Int J Cardiovasc Imaging 28:1435-44. 2012

Detail Information

Publications344 found, 100 shown here

  1. ncbi Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites
    D R Harder
    Cardiovascular Research Center and Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Stroke 29:229-34. 1998
    Cerebral blood flow is tightly coupled to neuronal metabolic activity, a phenomenon referred to as functional hyperemia. The mechanisms underlying functional hyperemia in the brain have been extensively studied, but the link between ..
  2. ncbi Reactive hyperemia and cardiovascular risk
    Andrew Philpott
    Arterioscler Thromb Vasc Biol 27:2065-7. 2007
  3. ncbi Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
    Jeffrey T Kuvin
    Department of Medicine, Division of Cardiology, Tufts New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA
    Am Heart J 146:168-74. 2003
    ..We evaluated the relationship between changes in PWA of the finger and peripheral endothelial function...
  4. ncbi Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
    Piero O Bonetti
    Center for Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 44:2137-41. 2004
    We investigated the value of reactive hyperemia peripheral arterial tonometry (RH-PAT) as a noninvasive tool to identify individuals with coronary microvascular endothelial dysfunction.
  5. pmc Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study
    Naomi M Hamburg
    Cardiology Section, Whitaker Cardiovascular Institute, School of Medicine, Boston University, Boston, Mass 01702, USA
    Circulation 117:2467-74. 2008
    Digital pulse amplitude augmentation in response to hyperemia is a novel measure of peripheral vasodilator function that depends partially on endothelium-derived nitric oxide...
  6. ncbi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
    ..We examined whether endothelial dysfunction, as detected by non-invasive peripheral arterial tonometry (EndoPAT), can predict late CV events...
  7. ncbi Role of nitric oxide in the regulation of digital pulse volume amplitude in humans
    Anju Nohria
    Cardiovascular Div, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Appl Physiol (1985) 101:545-8. 2006
    Measurement of the increase in digital pulse volume amplitude (PVA) during reactive hyperemia relative to baseline (PVA-RH) is being applied widely as a convenient test of nitric oxide bioavailability...
  8. ncbi Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 115:2390-7. 2007
    ..We assessed the hypothesis that FMD predicts incident cardiovascular events in a population-based cohort of older adults...
  9. ncbi Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease
    Piero O Bonetti
    Center for Coronary Physiology and Imaging and the Cardiac Catheterization Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Am Coll Cardiol 41:1761-8. 2003
    ..The goal of this study was to examine the effect of enhanced external counterpulsation (EECP) on endothelial function...
  10. pmc The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study
    Edward V R DiBella
    UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, USA
    Int J Cardiovasc Imaging 28:1435-44. 2012
    ..of heart disease, it is important to know whether the fixed dose of regadenoson produces maximal coronary hyperemia in subjects of widely varying body size. Thirty subjects (12 female, 18 male, mean BMI 30.3 ± 6.5, range 19...
  11. pmc Ultrasound assessment of flow-mediated dilation
    Ryan A Harris
    Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
    Hypertension 55:1075-85. 2010
    ..Therefore, this tutorial provides timely insight into recent advances and practical information related to the ultrasonic assessment of vascular endothelial function in humans...
  12. pmc Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Cardiovasc Magn Reson 13:66. 2011
    Post-occlusive hyperemia is often used as a paradigm to evaluate vascular reactivity, for example by measuring post-ischemic flow-mediated dilation, arterial blood flow or temporally resolved venous blood oxygenation (HbO2)...
  13. ncbi Direct observation of epicardial coronary capillary hemodynamics during reactive hyperemia and during adenosine administration by intravital video microscopy
    Takahiko Kiyooka
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Am J Physiol Heart Circ Physiol 288:H1437-43. 2005
    ..of the beating canine heart in vivo to elucidate its functional role under control conditions, during reactive hyperemia (RH), and during intracoronary adenosine administration...
  14. ncbi Association between glycosylated haemoglobin A(1c) and endothelial function in an adult non-diabetic population
    Roberto Lorbeer
    Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Germany
    Atherosclerosis 217:358-63. 2011
    ..To investigate the impact of long-term glucose homeostasis on endothelial function in an adult non-diabetic population, we analysed the association of serum HbA(1c) levels with endothelial function...
  15. ncbi Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Glifada, Athens, Greece
    Atherosclerosis 170:261-7. 2003
    ..Forearm vasodilatory response to reactive hyperemia (RH%) was expressed as the percentage change from baseline to post reactive hyperemia blood flow...
  16. ncbi Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation
    Brett J Wong
    Department of Exercise and Movement Science, University of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol 95:504-10. 2003
    Reactive hyperemia is the sudden rise in blood flow after release of an arterial occlusion. Currently, the mechanisms mediating this response in the cutaneous circulation are poorly understood. The purpose of this study was to 1)...
  17. ncbi Endothelial pulse amplitude testing: feasibility and reproducibility in adolescents
    Elif Seda Selamet Tierney
    Department of Cardiology, Children s Hospital, Boston, MA 02155, USA
    J Pediatr 154:901-5. 2009
    ..To test prospectively the reproducibility and feasibility of endothelial pulse amplitude testing (Endo-PAT), a novel Food and Drug Administration-approved technology, in healthy adolescents...
  18. pmc Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex
    Xiaoguang Liu
    Dept of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 North Wolfe St Blalock 1404, Baltimore, MD 21287 4961, USA
    Am J Physiol Heart Circ Physiol 295:H619-31. 2008
    ..These results indicate that 20-HETE synthesis normally does not substantially restrict functional hyperemia. Increased NO production during functional activation may act dynamically to suppress 20-HETE synthesis or ..
  19. ncbi Variability of peripheral arterial tonometry in the measurement of endothelial function in healthy men
    Jianmin Liu
    Research Development and Engineering, Altria Client Services, Richmond, Virginia
    Clin Cardiol 32:700-4. 2009
    ..5 hours (7 times within a day) to evaluate the variability of the reactive hyperemia index (RHI)...
  20. pmc Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain
    Francisco Fernández-Klett
    Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, D 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 107:22290-5. 2010
    ..However, our data suggest that precapillary and penetrating arterioles, rather than pericytes in capillaries, are responsible for the blood flow increase induced by neural activity...
  21. ncbi Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex
    Laibaik Park
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Cereb Blood Flow Metab 24:334-42. 2004
    ..the amyloid precursor protein (APP) and to determine whether the Abeta-induced attenuation in functional hyperemia is mediated by free radical overproduction...
  22. ncbi Resting Pd/Pa measured with intracoronary pressure wire strongly predicts fractional flow reserve
    Mamas A Mamas
    Manchester Heart Centre, Manchester Royal Infirmary, Biomedical Research Centre, Manchester, United Kingdom
    J Invasive Cardiol 22:260-5. 2010
    To investigate the relationship between resting distal coronary pressure to aortic pressure ratio (Pd/Pa) and fractional flow reserve (FFR) obtained during maximal hyperemia.
  23. ncbi Flow-mediated dilation of the radial artery is offset by flow-induced reduction in transmural pressure
    Benyu Jiang
    King s College London, British Heart Foundation Centre, London, United Kingdom
    Hypertension 57:1145-50. 2011
    ..dilation was measured in the radial artery using a standard protocol and after flow interruption at peak hyperemia during brachial artery infusion of saline and the NO synthase inhibitor N(G)-monomethyl-L-arginine (8 μmol/min)...
  24. ncbi Racial differences in central blood pressure and vascular function in young men
    Kevin S Heffernan
    Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, Rehabilitation Education Center, University of Illinois at Urbana Champaign, 1207 S Oak St Champaign, IL 61820, USA
    Am J Physiol Heart Circ Physiol 295:H2380-7. 2008
    ....
  25. ncbi Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia
    Sarah Itzhaki
    Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep 28:594-600. 2005
    The aim of this study was to investigate endothelial functioning in sleep apnea patients using a novel plethysmographic device that monitors peripheral arterial tone response in the finger to reactive hyperemia induced by forearm ischemia.
  26. ncbi Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model
    J J J van Giezen
    Department of Bioscience, AstraZeneca R and D, Molndal, Sweden
    J Cardiovasc Pharmacol Ther 17:164-72. 2012
    ....
  27. ncbi Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia
    N H Buus
    Center for Clinical Pharmacology, Department of Cardiology, PET Center, Aarhus University Hospital, Denmark
    Circulation 104:2305-10. 2001
    Myocardial perfusion during adenosine-induced hyperemia is used both in clinical diagnosis of coronary heart disease and for scientific investigations of the myocardial microcirculation...
  28. ncbi Body weight loss by very-low-calorie diet program improves small artery reactive hyperemia in severely obese patients
    J Merino
    Vascular Medicine and Metabolism Unit, Lipids and Atherosclerosis Research Unit, Sant Joan University Hospital, Institut d Investigació Sanitària Pere Virgili, Faculty of Medicine, Universitat Rovira i Virgili Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders CIBERDEM, Barcelona, Spain
    Obes Surg 23:17-23. 2013
    ..We aimed to assess the impact of weight loss induced by an intensive very-low-calorie diet (VLCD) on arterial wall function in severely obese patients (SOP)...
  29. ncbi Reproducibility of peripheral arterial tonometry for the assessment of endothelial function in adults
    Luísa C C Brant
    aBrazilian Longitudinal Study of Adult Health, ELSA Brasil bHospital das Clínicas and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    J Hypertens 31:1984-90. 2013
    ..However, there is a paucity of data about its reproducibility. The aim of this study was to assess the feasibility and reproducibility of PAT in adults...
  30. ncbi Effect of antianginal medication on resting myocardial perfusion and pharmacologically induced hyperemia
    Morten Bøttcher
    Department of Cardiology B, Aarhus University Hospital Skejby Sygehus, DK 8200 Aarhus N, Denmark
    J Nucl Cardiol 10:345-52. 2003
    ..The MET and AML groups were also studied during dipyridamole-induced hyperemia (0.56 mg. kg(-1). min(-1) for 4 minutes)...
  31. ncbi Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure-Only Ratios Against Indices Using Flow Study
    Sayan Sen
    International Centre for Circulatory Health, National Heart and Lung Institute, London, United Kingdom
    J Am Coll Cardiol 61:1409-20. 2013
    ..This study sought to determine if adenosine administration is required for the pressure-only assessment of coronary stenoses...
  32. ncbi Variability of flow-mediated dilation measurements with repetitive reactive hyperemia
    Ryan A Harris
    Clinical Exercise Physiology Laboratory, Indiana University, Bloomington, Indiana 47404, USA
    Vasc Med 11:1-6. 2006
    ..The effect of repetitive reactive hyperemia on endothelial function and the measurement of FMD are unknown...
  33. pmc Prolonged low flow reduces reactive hyperemia and augments low flow mediated constriction in the brachial artery independent of the menstrual cycle
    Mark Rakobowchuk
    Department of Biological Sciences, University of Essex, Colchester, United Kingdom
    PLoS ONE 8:e55385. 2013
    ..The data suggest substantial alterations in vascular function proximal to areas of ischemia with potential clinical implications following reperfusion...
  34. ncbi VERIFY (VERification of Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis Severity in EverydaY Practice): a multicenter study in consecutive patients
    Colin Berry
    BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
    J Am Coll Cardiol 61:1421-7. 2013
    This study sought to compare fractional flow reserve (FFR) with the instantaneous wave-free ratio (iFR) in patients with coronary artery disease and also to determine whether the iFR is independent of hyperemia.
  35. ncbi Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans
    Marvin S Medow
    Department of Pediatrics, The Center for Pediatric Hypotension, New York Medical College, 19 Bradhurst Avenue, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 293:H425-32. 2007
    ..COXs) or COX products inhibit nitric oxide (NO) synthesis and thereby mask potential effects of NO on reactive hyperemia in the cutaneous circulation...
  36. ncbi Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Circulation 112:3722-8. 2005
    ..Aortic stiffness and small-artery structure and function share various risk factors; however, relations between these 2 measures of vascular function are complex and incompletely understood...
  37. pmc Measurement of skeletal muscle perfusion during postischemic reactive hyperemia using contrast-enhanced MRI with a step-input function
    Richard B Thompson
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 54:289-98. 2005
    The regional distribution of skeletal muscle blood flow was measured during postischemic reactive hyperemia using Gd-DTPA contrast-enhanced (CE) MRI...
  38. ncbi Cardiac PET imaging for the detection and monitoring of coronary artery disease and microvascular health
    Thomas H Schindler
    Nuclear Cardiology and Cardiac Imaging, Division of Cardiology, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland
    JACC Cardiovasc Imaging 3:623-40. 2010
    ..Individualized, image-guided cardiovascular therapy may likely change this paradigm in the near future...
  39. pmc Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise
    David M Gundermann
    The Univ of Texas Medical Branch, Dept of Nutrition and Metabolism, Division of Rehabilitation Sciences, 301 Univ Blvd, Galveston, TX 77555 1124, USA
    J Appl Physiol (1985) 112:1520-8. 2012
    ..The purpose of this study was to test the hypothesis that reactive hyperemia is the mechanism responsible for stimulating mTORC1 signaling and MPS following BFR exercise...
  40. ncbi Noninvasive interrogation of microvasculature for signs of endothelial dysfunction in patients with chronic renal failure
    Julian Stewart
    Division of Nephrology and Renal Research Institute, New York Medical College, Center for Pediatric Hypotension, Suite 618, Munger Pavilion, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2687-96. 2004
    ..flowmetry (LDF) and scanned laser Doppler imaging (LDI) to quantify parameters of the postocclusion reactive hyperemia and thermal hyperemic responses (local heating to 43 degrees C) in ESRD patients (n=63) and healthy individuals (..
  41. pmc Muscle protein metabolism responds similarly to exogenous amino acids in healthy younger and older adults during NO-induced hyperemia
    E Lichar Dillon
    Divisions of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1408-17. 2011
    ..older individuals, respectively. Provision of AAs during NO-induced local skeletal muscle hyperemia stimulates skeletal muscle protein metabolism in older adults to a similar extent as in younger adults...
  42. ncbi Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry
    M Roustit
    Inserm CIC3, Grenoble Clinical Research Center, Grenoble University Hospital, France
    Microvasc Res 79:102-8. 2010
    The primary objective of this study was to evaluate 1-week reproducibility of post-occlusive reactive hyperemia (PORH) and local thermal hyperemia (LTH) assessed by single-point laser-Doppler flowmetry (LDF) on different skin sites...
  43. ncbi Ocular surface tolerability of prostaglandin analogs in patients with glaucoma or ocular hypertension
    Jess T Whitson
    UT Southwestern Medical Center, Dallas, Texas 75390 8866, USA
    J Ocul Pharmacol Ther 26:287-92. 2010
    ..005% preserved with 0.02% benzalkonium chloride (BAK), bimatoprost 0.03% preserved with 0.005% BAK, and travoprost 0.004% preserved with the proprietary preservative system sofZia in patients previously treated with latanoprost...
  44. ncbi Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction
    Ji Song
    Dept of Biomedical Engineering, Univ of Virginia, Box 800759, UVA Health System, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 287:H2754-61. 2004
    ..with pulsed 1-MHz ultrasound creates a bioeffect that stimulates arteriogenesis and a chronic increase in hyperemia blood flow in normal rat muscle...
  45. pmc Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy
    Anusha Mishra
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    Glia 58:1996-2004. 2010
    ..This response, termed functional hyperemia, is diminished in the retinas of diabetic patients, possibly contributing to the development of diabetic ..
  46. ncbi Digital assessment of endothelial function and ischemic heart disease in women
    Yasushi Matsuzawa
    Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 55:1688-96. 2010
    We investigated the utility of digital reactive hyperemia peripheral arterial tonometry (RH-PAT) in predicting ischemic heart disease (IHD), including obstructive coronary artery disease (CAD) and nonobstructive coronary artery disease (..
  47. ncbi Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 44:134-9. 2004
    ..Flow-mediated dilation of the brachial artery in response to postischemic reactive hyperemia is impaired in patients with cardiovascular disease risk factors and may reflect local endothelial dysfunction ..
  48. ncbi Influence of vascular filling and perfusion on BOLD contrast during reactive hyperemia in human skeletal muscle
    S Duteil
    NMR Laboratory, AFM and CEA, IFR 14, Institut de Myologie, Pitie Salpetriere University Hospital, Paris, France
    Magn Reson Med 55:450-4. 2006
    ..perfusion by ASL, and BOLD response in the calf muscle of 6 healthy volunteers during post-ischemic reactive hyperemia. We tested whether the relation between the two was altered for varying degrees of leg vascular replenishment ..
  49. ncbi Adenosine-induced maximal coronary hyperemia for myocardial fractional flow reserve measurements: comparison of administration by femoral venous versus antecubital venous access
    Michael Lindstaedt
    Medizinische Klinik II, Universitätsklinik Bergmannsheil, Ruhr Universitat Bochum, 44789 Bochum, Germany
    Clin Res Cardiol 98:717-23. 2009
    Maximal hyperemia is a critical prerequisite for correct fractional flow reserve (FFR) measurements. Continuous administration of adenosine by femoral venous access is considered the gold-standard...
  50. ncbi Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy
    Claire Mayeur
    Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Universite Paris Sud, Le Kremlin Bicetre, France
    Crit Care Med 39:695-701. 2011
    ..The data may support a standardized method to appropriately measure the postischemic recovery slope, which is currently emphasized as a quantitative marker of the microvascular reserve in septic patients...
  51. ncbi Postischemic reperfusion: ultrastructural blood-brain barrier and hemodynamic correlative changes in an awake model of transient forebrain ischemia
    Miguel A Melgar
    Department of Neurosurgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Neurosurgery 56:571-81. 2005
    ..The purpose of this study was to characterize the time course of CBF and BBB ultrastructural changes during reperfusion in an awake, recovery model of transient global forebrain ischemia (GFI)...
  52. ncbi Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice?
    Christian Binggeli
    Cardiovascular Center, Division of Cardiology, University Hospital, CH 8091 Zurich, Switzerland
    J Am Coll Cardiol 42:71-7. 2003
    ..The present study aims to investigate whether laser Doppler flowmetry can be used to monitor improvements in vascular function during statin therapy...
  53. ncbi Fractional flow reserve to guide coronary revascularization
    Nico H J Pijls
    Catharina Hospital, Eindhoven, The Netherlands
    Circ J 77:561-9. 2013
    ..is given with respect to using resting pressure indexes, which seem attractive because they avoid the need for hyperemia, but negatively affect the accuracy of the measurements...
  54. pmc Role of echo Doppler ultrasonography in the evaluation of postprandial hyperemia in cirrhotic patients
    Osman Ozdogan
    Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey
    World J Gastroenterol 14:260-4. 2008
    To assess the role of echo-Doppler ultrasonography in postprandial hyperemia in cirrhotic patients by comparing the results with the hepatic vein catheterization technique.
  55. ncbi Maximal hyperemia in the assessment of fractional flow reserve: intracoronary adenosine versus intracoronary sodium nitroprusside versus intravenous adenosine: the NASCI (Nitroprussiato versus Adenosina nelle Stenosi Coronariche Intermedie) study
    Antonio Maria Leone
    Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy
    JACC Cardiovasc Interv 5:402-8. 2012
    ..This study sought to compare increasing doses of intracoronary (i.c.) adenosine or i.c. sodium nitroprusside versus intravenous (i.v.) adenosine for fractional flow reserve (FFR) assessment...
  56. ncbi Does the instantaneous wave-free ratio approximate the fractional flow reserve?
    Nils P Johnson
    Weatherhead PET Center for Preventing and Reversing Atherosclerosis, Division of Cardiology, Department of Medicine, University of Texas Medical School and Memorial Hermann Hospital, Houston, Texas
    J Am Coll Cardiol 61:1428-35. 2013
    ..This study sought to examine the clinical performance of and theoretical basis for the instantaneous wave-free ratio (iFR) approximation to the fractional flow reserve (FFR)...
  57. ncbi Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts
    Annie Rochetaing
    Laboratoire de Préconditionnement et de Remodelage du Myocarde, UFR Sciences, Angers Cedex, France
    J Thorac Cardiovasc Surg 125:1516-25. 2003
    Our study was undertaken to clarify the impact of the shear stress-induced reactive hyperemia (associated with reperfusion) in preconditioning-mediated protection.
  58. pmc Peripheral microvascular response to muscle contraction is unaltered by early diabetes but decreases with age
    Jill M Slade
    Dept of Radiology, East Lansing, MI 48824, USA
    J Appl Physiol (1985) 111:1361-71. 2011
    ..Peripheral macrovascular function of the popliteal and tibial arteries was assessed during exercise hyperemia with phase contrast magnetic resonance angiography following repetitive exercise...
  59. ncbi Evaluation of the haemodynamic characteristics of drug-eluting stents at implantation and at follow-up
    Marcel van't Veer
    Department of Cardiology, Catharina Hospital, PO Box 1350, 5602 ZA Eindhoven, The Netherlands
    Eur Heart J 27:1811-7. 2006
    ....
  60. ncbi Diagnostic accuracy of combined intracoronary pressure and flow velocity information during baseline conditions: adenosine-free assessment of functional coronary lesion severity
    Tim P van de Hoef
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Cardiovasc Interv 5:508-14. 2012
    ..reserve and the more widely used fractional flow reserve relies critically on the establishment of maximal hyperemia. We evaluated the diagnostic accuracy of the stenosis resistance index during nonhyperemic conditions, baseline ..
  61. ncbi Automatic model-based analysis of skeletal muscle BOLD-MRI in reactive hyperemia
    Kiril Schewzow
    MR Center of Excellence, Medical University of Vienna, Austria Department of Clinical Pharmacology, Medical University of Vienna, Austria Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria
    J Magn Reson Imaging 38:963-9. 2013
    To propose a quantitative model for a reliable and operator independent estimation of parameters describing blood oxygen-level dependent (BOLD) MRI time course in calf muscles during reactive hyperemia.
  62. ncbi Blood oxygenation level-dependent (BOLD) MRI of human skeletal muscle at 1.5 and 3 T
    Sasan Partovi
    Department of Radiology, University Hospital Bruderholz, Basel, Switzerland
    J Magn Reson Imaging 35:1227-32. 2012
    To evaluate the dependence of skeletal muscle blood oxygenation level-dependent (BOLD) effect and time course characteristics on magnetic field strength in healthy volunteers using an ischemia/reactive hyperemia paradigm.
  63. pmc Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults
    Anne R Crecelius
    Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado 80523 1582, USA
    Am J Physiol Heart Circ Physiol 299:H1633-41. 2010
    ..Together, our data indicate that the increase in muscle blood flow during dynamic exercise with acute AA administration in older adults is mediated primarily via an increase in the bioavailability of NO derived from the NOS pathway...
  64. ncbi Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts
    Jurgen W G E VanTeeffelen
    Dept of Medical Physics, Cardiovascular Research Institute Amsterdam, Academic Medical Center, Univ of Amsterdam, Meibergdreef 15, 1100 AZ Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 289:H2508-13. 2005
    Because adenosine is commonly used for inducing maximal coronary hyperemia in the clinic, it is imperative that adenosine-induced hyperemia (AH) resembles coronary hyperemia that can be attained by endogenous stimuli...
  65. pmc Effect of extraluminal ATP application on vascular tone and blood flow in skeletal muscle: implications for exercise hyperemia
    Michael Nyberg
    Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R281-90. 2013
    ..muscle blood flow, indicating that the contraction-induced increase in skeletal muscle interstitial [ATP] is important for exercise hyperemia. The vasodilator effect of ATP application is mediated by NO and prostanoid formation.
  66. ncbi Vascular smooth muscle: integrator of vasoactive signals during exercise hyperemia
    M H Laughlin
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Med Sci Sports Exerc 33:81-91. 2001
    ..of this review is to discuss the importance of vascular smooth muscle function in mechanisms underlying exercise hyperemia in skeletal muscle...
  67. ncbi Evidence for a rapid vasodilatory contribution to immediate hyperemia in rest-to-mild and mild-to-moderate forearm exercise transitions in humans
    Natasha R Saunders
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Appl Physiol 97:1143-51. 2004
    Controversy exists regarding the contribution of a rapid vasodilatory mechanism(s) to immediate exercise hyperemia. Previous in vivo investigations have exclusively examined rest-to-exercise (R-E) transitions where both the muscle pump ..
  68. ncbi Relationship between peripheral arterial reactive hyperemia and residual platelet reactivity after 600 mg clopidogrel
    Michalis Hamilos
    Cardiovascular Center Aalst, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium
    J Thromb Thrombolysis 32:64-71. 2011
    ..before and at least 12 h after 600 mg clopidogrel in 43 SA pts undergoing elective PCI by: (a) reactive hyperemia peripheral arterial tonometry (measuring the Endoscore); (b) circulating endothelial microparticles (EMPs)...
  69. ncbi Minimum recovery time between reactive hyperemia stimulus in the repeated measurement of brachial flow-mediated dilatation
    Matthew Barton
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutrition Science, University of Reading, Reading, United Kingdom
    Ultrasound Med Biol 37:879-83. 2011
    ....
  70. ncbi Postocclusive reactive hyperemia in healthy volunteers and patients with peripheral vascular disease measured by three noninvasive methods
    Tomaz Jarm
    University of Ljubljana, Faculty of Electrical Engineering, Trzaska 25, SI 1000 Ljubljana, Slovenia
    Adv Exp Med Biol 530:661-9. 2003
    Postocclusive reactive hyperemia (PORH) was evaluated in three healthy volunteers and in three patients with different etiologies and suffering from peripheral arterial occlusive disease (PAOD)...
  71. ncbi High-throughput ambulatory assessment of digital reactive hyperemia: concurrent validity with known cardiovascular risk factors and potential confounding
    Elisabeth Truschel
    Mannheim Institute of Public Health, Social and Preventive Medicine, Universitatsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Ludolf Krehl Strasse 7 11, 68167 Mannheim, Germany
    Prev Med 49:468-72. 2009
    Reactive hyperemia index (RHI) measurement through digital peripheral arterial tonometry (PAT) is proposed for cardiovascular disease (CVD) risk screening...
  72. pmc Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, New York, New York, USA
    Am J Physiol Heart Circ Physiol 301:H704-11. 2011
    ..postural tachycardia syndrome (POTS) is a form of chronic orthostatic intolerance associated with splanchnic hyperemia. To test the hypothesis that there is excessive constitutive NOS in POTS, we determined whether cutaneous ..
  73. ncbi BOLD MRI mapping of transient hyperemia in skeletal muscle after single contractions
    Ronald A Meyer
    Department of Physiology, Molecular Imaging Research Center, Michigan State University, East Lansing 48824, USA
    NMR Biomed 17:392-8. 2004
    ..The transients can be exploited for muscle functional imaging analogous to BOLD-based brain functional imaging, and might provide an index of peripheral vascular function...
  74. ncbi Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy
    Debbie L Shawcross
    Liver Failure Group, Institute of Hepatology, Royal Free and University College London Medical School, London, UK
    Hepatology 39:471-5. 2004
    ..of terlipressin, at a dose that did not alter systemic hemodynamics, resulted in worsening of cerebral hyperemia and intracranial hypertension in patients with ALF and severe hepatic encephalopathy...
  75. ncbi Assessment of peripheral vascular endothelial function in the ambulatory setting
    Jeffrey T Kuvin
    Department of Medicine Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Vasc Med 12:13-6. 2007
    ..In this study, we evaluated endothelial function in two peripheral vascular beds before and during reactive hyperemia in an outpatient clinic setting...
  76. ncbi Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes
    Michael J Haller
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, FL, USA
    Pediatr Diabetes 8:193-8. 2007
    To assess the ability of reactive hyperemia-peripheral artery tonometry (RH-PAT) to serve as a surrogate marker of endothelial dysfunction in children with type 1 diabetes (T1D).
  77. ncbi Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Atherosclerosis 178:359-63. 2005
    ..Data are expressed as median [25th-75th percentile]. Forearm vasodilatory response to reactive hyperemia was significantly improved in atorvastatin-treated patients (from 38.1% [32.0-59.1] to 70.0% [61.1-106...
  78. ncbi Increased laser Doppler flow in skin tumors corresponds to elevated vessel density and reactive hyperemia
    Markus Stucker
    Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    Skin Res Technol 12:1-6. 2006
    ..This study investigated whether this phenomenon is originated by elevated blood vessel density or by reactive hyperemia.
  79. ncbi Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans
    Jean Luc Cracowski
    Clinical Pharmacology Department, Institut National de la Santé et de la Recherche Médicale CIC3, University Hospital, Grenoble, France
    J Appl Physiol (1985) 114:245-51. 2013
    Several mediators contribute to postocclusive reactive hyperemia (PORH) of the skin, including sensory nerves and endothelium-derived hyperpolarizing factors...
  80. ncbi Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice
    Mia Phillipson
    Dept of Medical Cell Biology, Uppsala University, PO Box 571, SE 751 23 Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 285:G154-62. 2003
    The role of different isoforms of nitric oxide synthase (NOS) in the gastric mucosal hyperemia, induced by 155 mM luminal hydrochloric acid (pH approximately 0.8) without a barrier breaker, was investigated...
  81. ncbi Reproducibility of parameters of postocclusive reactive hyperemia measured by near infrared spectroscopy and transcutaneous oximetry
    R Kragelj
    Faculty of Electrical Engineering, University of Ljubljana, Trzaska, Slovenia
    Ann Biomed Eng 28:168-73. 2000
    ..The combined use of both methods yields deeper insight into conditions of blood flow and tissue oxygenation...
  82. ncbi Automated hyperemia analysis software: reliability and reproducibility in healthy subjects
    Tsuyoshi Yoneda
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku 783 8505, Japan
    Jpn J Ophthalmol 56:1-7. 2012
    To evaluate the reliability and reproducibility of automated software to analyze human bulbar hyperemia.
  83. pmc Low fingertip temperature rebound measured by digital thermal monitoring strongly correlates with the presence and extent of coronary artery disease diagnosed by 64-slice multi-detector computed tomography
    Naser Ahmadi
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Int J Cardiovasc Imaging 25:725-38. 2009
    ..temperature rebound measured by digital thermal monitoring (DTM) during a 5 min arm-cuff induced reactive hyperemia and both the Framingham Risk Score (FRS), and coronary artery calcification (CAC) in asymptomatic populations...
  84. ncbi Laser Doppler imaging of reactive hyperemia exposes blood flow deficits in a rat model of experimental limb ischemia
    Halea A Corcoran
    Department of Molecular Endocrinology, Merck Research Laboratories, West Point, PA 19454, USA
    J Cardiovasc Pharmacol 53:446-51. 2009
    ..These findings will enhance the ability to effectively study pharmacologic therapies aimed at promoting the growth and development of collateral vessels...
  85. pmc Limb movement-induced hyperemia has a central hemodynamic component: evidence from a neural blockade study
    Joel D Trinity
    Geriatric Research, Education, and Clinical Center, George E Whalen Veterans Affairs Medical Center, Salt Lake City, Utah, USA
    Am J Physiol Heart Circ Physiol 299:H1693-700. 2010
    ..response due to passive limb movement, which then results in an attenuated and delayed movement-induced hyperemia. In combination, these findings provide evidence that limb movement-induced hyperemia has a significant central ..
  86. ncbi Repetitive concentric wave-ring spread of oligemia/hyperemia in the sensorimotor cortex accompanying K(+)-induced spreading depression in rats and cats
    Yutaka Tomita
    Department of Neurology, Saitama Municipal Hospital, 2460 Mimuro, Saitama City, Saitama 336 8522, Japan
    Neurosci Lett 322:157-60. 2002
    ..provoked CBV changes that appeared as a repetitive propagation of concentric wave-rings of ischemia followed by hyperemia expanding peripherally from the injection site at speeds of 1.9-3.2 mm/min...
  87. ncbi Electroacupuncture attenuates both glutamate release and hyperemia after transient ischemia in gerbils
    Jinning Pang
    Department of Neurobiology, Kagawa Medical University, Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Am J Chin Med 31:295-303. 2003
    ..both ischemia-induced glutamate release and transient increase of cerebral blood flow (CBF) during reperfusion (hyperemia)...
  88. ncbi A model for post-occlusive reactive hyperemia as measured with laser-Doppler perfusion monitoring
    Frits F M de Mul
    Department of Biomedical Engineering, University of Groningen, Faculty of Medicine, 9713 AV Groningen, The Netherlands
    IEEE Trans Biomed Eng 52:184-90. 2005
    ..For this reason, we also developed a computer program to perform the fit of the model to measured data...
  89. ncbi Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats
    Jefferson C Frisbee
    Center for Interdisciplinary Research in Cardiovascular Science, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26505, USA
    Am J Physiol Heart Circ Physiol 290:H2066-74. 2006
    ..Treatment of animals with an antioxidant (polythethylene glycol-superoxide dismutase) had no effect on reactive hyperemia, although blockade of alpha-adrenoreceptors (alpha1 > alpha2) improved responses to 30 and 90 s of occlusion; ..
  90. ncbi Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease
    Dimitris Tousoulis
    Int J Cardiol 124:127-9. 2008
  91. ncbi Isocortical hyperemia and allocortical inflammation and atrophy following generalized convulsive seizures of thalamic origin in the rat
    Sima Mraovitch
    Laboratoire de Recherches Cerebrovasculaires, CNRS, FRE 2363, Universite Paris VII, Paris, France
    Cell Mol Neurobiol 23:773-91. 2003
    ..However the origin of medial lobe atrophy remain uncertain. Our results provide evidence that the allocortical microvascular inflammation may be in origin of the neurovascular degenerative processes leading to atrophy...
  92. ncbi Impact of repeated increases in shear stress via reactive hyperemia and handgrip exercise: no evidence of systematic changes in brachial artery FMD
    K E Pyke
    Cardiovascular Stress Response Laboratory, School of Kinesiology and Health Studies, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Heart Circ Physiol 300:H1078-89. 2011
    Reactive hyperemia (RH) creates an uncontrolled, transient increase in brachial artery (BA) shear stress (SS) for flow-mediated dilation (FMD) assessment...
  93. pmc Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans
    Mark Rakobowchuk
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Exp Physiol 97:375-85. 2012
    ..However, circulating progenitor cell numbers were not increased, suggesting that these cells are not likely to be upregulated as a result of training...
  94. ncbi Evidence of functional hyperemia in the rat hippocampus during mild treadmill running
    Takeshi Nishijima
    Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba 305 8574, Ibaraki, Japan
    Neurosci Res 54:186-91. 2006
    ..We aimed to examine whether functional hyperemia, an increase in cerebral blood flow in response to neuronal activation, can occur in the exercising rat ..
  95. ncbi Inhibition of phospholipase A2 attenuates functional hyperemia in the hamster cremaster muscle
    L C Nuttle
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol 276:H1289-94. 1999
    ..This study was designed to determine the role of phospholipase A2 (PLA2) and AA release in functional hyperemia in the hamster cremaster muscle...
  96. ncbi Characterizing reactive hyperemia via tissue reflectance spectroscopy in response to an ischemic load across gender, age, skin pigmentation and diabetes
    Stephen Sprigle
    Helen Hayes Hospital, Center for Rehabilitation Technology, Rte 9W, NY, West Haverstraw 10993, USA
    Med Eng Phys 24:651-61. 2002
    ..This study characterized the hyperemic response to a localized ischemic load in people with diabetes and amputation and compared it to that of subjects without diabetes or amputation...
  97. ncbi Low flow-mediated constriction occurs in the radial but not the brachial artery in healthy pregnant and nonpregnant women
    Tracey L Weissgerber
    Department of Obstetrics, Gynecology, and Reproductive Science, Magee Women s Research Institute, 204 Craft Ave, Pittsburgh, PA 15213, USA
    J Appl Physiol (1985) 108:1097-105. 2010
    ..Studies should clarify the underlying stimulus and mechanisms regulating L-FMC, and test the hypothesis that endothelial dysfunction is manifested as enhanced brachial artery L-FMC, but attenuated radial artery L-FMC...
  98. ncbi Two weeks of muscle immobilization impairs functional sympatholysis but increases exercise hyperemia and the vasodilatory responsiveness to infused ATP
    S P Mortensen
    The Copenhagen Muscle Research Centre, Rigshospitalet, Denmark
    Am J Physiol Heart Circ Physiol 302:H2074-82. 2012
    ..These results suggest that muscle inactivity impairs functional sympatholysis and that the magnitude of hyperemia and blood pressure response to exercise is dependent on the training status of the muscle...
  99. ncbi Effect of reactive hyperemia after coronary recanalization on myocardial tissue reperfusion by thrombolysis in myocardial infarction flow grade in acute myocardial infarction
    Atsunori Okamura
    Division of Cardiology, Sakurabashi Watanabe Hospital, Watanabe, Japan
    Am J Cardiol 97:617-23. 2006
    ..70, -2.69 +/- 0.31, and -2.88 +/- 0.48 SD/chord, respectively, p <0.01). In conclusion, compensatory reactive hyperemia preserves epicardial coronary flow velocity even in patients with microvascular damage, and with the progression ..
  100. ncbi Simultaneous dynamic blood oxygen level-dependent magnetic resonance imaging of foot and calf muscles: aging effects at ischemia and postocclusive hyperemia in healthy volunteers
    Sebastian Kos
    Institute of Radiology, Divisions of Interventional Radiology, University of Basel Hospital, Basel, Switzerland
    Invest Radiol 44:741-7. 2009
    ..of simultaneous blood oxygen level-dependent (BOLD) magnetic resonance imaging of calf and foot muscles and investigate age-related changes of BOLD signal changes during ischemia and postocclusive hyperemia in healthy volunteers.
  101. ncbi Postocclusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosis
    Jean Luc Cracowski
    INSERM ESPRI HP2 Laboratory, EA 3745, Grenoble Medical School, Grenoble, France
    Free Radic Biol Med 40:1732-7. 2006
    ..The primary objective of this study was to test whether there is a link between peak postocclusive hyperemia and urinary levels of the F2-isoprostane 15-F2t-IsoP (8-iso-PGF2alpha) in patients suffering from systemic ..

Research Grants66

  1. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..tissue, are associated with smooth muscles that allow them to constrict and dilate, a process termed functional hyperemia. The chemical signaling that controls the capillaries'diameter primarily originates from astrocytes, glial ..
  2. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..skeletal muscle into respective feed arteries (ascending vasodilation;AVD) is an essential component of exercise hyperemia. Pilot data from mice with mild HHcy (deficiency in the homocysteine-metabolizing enzyme, CBS v wild type ..
  3. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..change the MAPK isoform expression/activation profile in an LRP dependent process to elicit both initial hyperemia and NMDA impairment of cerebral hemodynamics producing marked histopathology post insult in the newborn but only ..
  4. Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible Subjects
    Mark W Frampton; Fiscal Year: 2010
    ..vascular function will be assessed using blood pressure and heart rate, forearm plethysmography and reactive hyperemia, platelet activation, and circulating microparticles...
  5. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..in venous oxygen saturation serving as an endogenous label in the femoral artery and vein during reactive hyperemia, (2) a high- speed, ungated, projection-based technique for measuring time-resolved arterial blood flow, (3) a ..
  6. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2013
    ..Function - based on ultrasound measurement of flow mediated dilatation of the brachial artery during reactivity hyperemia;and 5) Metabolic Risk - determined based on meeting standard criteria for the metabolic syndrome or exhibiting ..
  7. CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE
    Costantino Iadecola; Fiscal Year: 2013
    ..to the brain by altering vital regulatory mechanisms that assure adequate cerebral perfusion, such as functional hyperemia and cerebrovascular autoregulation;(2) CIH exerts its deleterious cerebrovascular effects by inducing vascular ..
  8. Arginine, Nitric Oxide, and Severe Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..shown that adults with moderately severe malaria have endothelial dysfunction as determined by abnormal reactive hyperemia-peripheral arterial tonometry measurements. This reactive hyperemia is primarily dependent on NO...
  9. MODifiable Effectors of Renin System Activation: Treatment Evaluation
    John P Forman; Fiscal Year: 2013
    ..The secondary endpoint will be endothelial dependent dilation measured by reactive hyperemia with high resolution ultrasound, and the tertiary endpoint will mean 24 hour systolic and diastolic blood ..
  10. Characterization of persistent hyperemic foci and their role in photocarcinogenes
    Raymond L Konger; Fiscal Year: 2013
    ..We show that focal areas of hyperemia occur following the application of chemical carcinogens or ultraviolet (UV) light to mouse skin...
  11. Thoroughfare Channels in CBF Autoregulation at High ICP
    Edwin M Nemoto; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cerebral edema, hyperemia and elevated intracranial pressure (ICP) frequently occur after stroke, traumatic brain injury, cardiac arrest, hepatic encephalopathy, etc...
  12. Ultrasound Assessment of Microvascular Function in Insulin Resistant Primates
    Jonathan R Lindner; Fiscal Year: 2011
    ..and in proportion to abnormal capillary responses to other physiologic responses such as exercise, reactive hyperemia, and NO-dependent vasodilation. ...
  13. Endothelial Insulin Resistance, Inflammation and Vascular Function in Diabetes
    NAOMI MIRIAM HAMBURG; Fiscal Year: 2013
    ..of endothelial vasomotor dysfunction (flow-mediated dilation, peripheral arterial tonometry and reactive hyperemia) in 120 patients with diabetes and 120 control subjects...
  14. Microcirculation in Health and Disease
    Robert L Hester; Fiscal Year: 2012
    ..flow in response to exercise, and the mechanisms underlying this abnormal increase in blood flow (functional hyperemia) are unclear...
  15. Comprehensive Magnetic Resonance in PAD
    Christopher M Kramer; Fiscal Year: 2013
    ..Cuff occlusion/hyperemia as a means of increasing blood flow may be best suited to those who can't exercise and may be more ..
  16. Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic Brain
    Maiken Nedergaard; Fiscal Year: 2010
    ..neural activity form the basis for functional brain imaging, yet the mechanisms of such activity-dependent hyperemia remain poorly defined...
  17. Impact of Aging on Skeletal Muscle Blood Flow Kinetics During Exercise
    DARREN PATRICK CASEY; Fiscal Year: 2013
    ..SUMMARY/ABSTRACT During dynamic exercise skeletal muscle blood flow increases rapidly and dramatically (exercise hyperemia) to meet the metabolic needs of the contracting tissue...
  18. Impact of Aging on Skeletal Muscle Blood Flow Kinetics During Exercise
    DARREN PATRICK CASEY; Fiscal Year: 2012
    ..by applicant): During dynamic exercise skeletal muscle blood flow increases rapidly and dramatically (exercise hyperemia) to meet the metabolic needs of the contracting tissue...
  19. MRI Assessment of Vascular Reactivity
    Felix W Wehrli; Fiscal Year: 2013
    ..protocol comprise high-speed projection mapping of time-resolved femoral artery velocity at baseline and during hyperemia, simultaneously with a method for quantifying the dynamics of venous blood oxygen resaturation during hyperemia, ..
  20. Inhibition of NO Dependent Splanchnic Hyperemia Improves CFS/POTS
    ANTHONY JAMES OCON; Fiscal Year: 2012
    ..that many CFS/POTS patients have a redistributive form of central hypovolemia that is associated with splanchnic hyperemia and hypervolemia also known as "splanchnic pooling"...
  21. Surrogate measures of endothelial dysfunction with integrated MRI
    MICHAEL LANGHAM; Fiscal Year: 2013
    ..the femoral artery and for quantifying the time-course of blood oxygen resaturation in the femoral vein during hyperemia, referred to as "dynamic oximetry...
  22. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..supine testing designed to specifically stimulate a specific reflex (limb hang, large pressure step and reactive hyperemia) and measuring peripheral resistance. 3) Cardiac autonomic findings are secondary to circulatory changes...
  23. In vivo two-photon imaging of brain vascular endothelial cell calcium dynamics
    TYLER CLARK BROWN; Fiscal Year: 2013
    ..unit leads to increased blood flow and volume to the activated brain region, a process known as "functional hyperemia"...
  24. Supressor ANGII Determines Acute & Chronic Renal Injury
    Luis A Juncos; Fiscal Year: 2010
    ..is characterized by oxidant-dependent increases in renal vascular reactivity, blunting of salt-induced cortical hyperemia, and attendant salt-sensitive HTN;additionally, SP-Angll upregulates inflammatory chemokines (i.e...
  25. Physiology of Inflammatory Arthritis in High Resolution
    Xueding Wang; Fiscal Year: 2013
    ..we will explore the potential of SPAT in assessing new physiological biomarkers of synovitis including hyperemia and hypoxia...
  26. Nutritional and Contractile Regulation of Muscle Growth
    Blake B Rasmussen; Fiscal Year: 2012
    ..based on our preliminary data, our general hypothesis is that anabolic nutrients, metabolic stress/reactive hyperemia, and age are independent factors that can regulate anabolic signaling, anabolic and catabolic gene expression, ..
  27. Potassium Channels as Macromolecular Complexes
    Thomas A Neubert; Fiscal Year: 2013
    ..regulation of basal flow as well as responses to metabolic impairment (hypoxic dilatation and ischemic reactive hyperemia)...
  28. Elucidating Pathways of Vascular Dysfunction and Myocardial Injury in ESRD
    Ruth Dubin; Fiscal Year: 2013
    ..function (area under the curve (AUC) of the brachial artery velocity-time relationship during reactive hyperemia), and arterial stiffness (assessed as pulse wave velocity (PWV))...
  29. Brain Vasodilator Responses in Healthy and Cognitively Impaired Humans
    JILL NICOLE BARNES; Fiscal Year: 2012
    ..CO2-mediated vasodilation in the middle cerebral artery (MCA) and the forearm blood flow response to reactive hyperemia in 3 groups: 1) young healthy adults;2) cognitively intact older adults;and 3) older adults with MCI...
  30. Glial cell regulation of blood flow in the normal and diabetic retina
    Eric A Newman; Fiscal Year: 2013
    ..Stimulating the eye with light results in an increase in retinal blood flow, a response termed functional hyperemia. This response, which supplies active neurons with oxygen and nutrients, is essential for healthy retinal ..
  31. CM-65, a Targeted Contrast Agent for Cardiac Magnetic Resonance Perfusion Imaging
    Valerie Humblet; Fiscal Year: 2013
    ..We have shown in preliminary studies in pigs that CM-65 can be administered during stress (hyperemia) and identify perfusion defects in the heart even after stress is ceased...
  32. Biological Spatial Resolution Limits in fMRI
    JONATHAN RIZZO POLIMENI; Fiscal Year: 2013
    ..identifying pathological tissue in patients with visual deficits or amblyopia, measuring the impact of localized hyperemia in patients with occipital cerebral amyloid angiopathy, designing cortical prostheses, and will enable future ..
  33. Role of Adenosine in Compensatory Dilation During Hypoxic Exercise
    DARREN PATRICK CASEY; Fiscal Year: 2010
    ..major role in hypoxia-induced skeletal muscle vasodilation but does not appear to be obligatory during exercise hyperemia. In this context, this application addresses the overall hypothesis that adenosine participates in the ..
  34. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
    ..week in glaucoma patients with careful monitoring of: local and systemic symptoms; visual acuity; conjunctival hyperemia; accommodative amplitude; pupillary diameter; aqueous flare; anterior chamber cellular response; IOP; pulse; ..
  35. Testing the Hemo-Neural Hypothesis: Tetrode, Two-photon &Computational Studies
    Dorea Vierling-Claassen; Fiscal Year: 2012
    ..applicant): Neural activity creates a spatio-temporally localized increase in blood supply known as functional hyperemia, known to underlie neuroimaging signals such as functional magnetic resonance imaging...
  36. REGULATING CEREBRAL MICROCIRCULATION BY ASTROCYTES
    DAVID RAE HARDER; Fiscal Year: 2013
    ..to modify the extent of hyperemic flow by constricting cerebral arterioles which are activated during functional hyperemia, or play an, as of yet, unidentified role...
  37. In-vivo imaging of the evolution of hemodynamic control in the developing brain
    MARIEL GAILEY KOZBERG; Fiscal Year: 2013
    ..of the response between postnatal days 12 - 23 via an intermediate bi-phasic response in which localized initial hyperemia gradually increased until the response was fully positive...
  38. Investigating astrocytic Gq-GPCR and Ca2+ signaling in functional hyperemia in vi
    Daniel Bonder; Fiscal Year: 2013
    ..with neuronal metabolic demand, blood flow to active brain regions is increased, a phenomenon termed functional hyperemia. This vascular response is the basis of blood oxygen level-dependent (BOLD) functional MRI, an important tool ..
  39. An Experimental Investigation into Staging CTS Utilizing Portable Ultrasound...
    Kevin D Evans; Fiscal Year: 2011
    ..Power Doppler has the ability to record acute changes such as hyperemia and increased blood flow in the perineural arterioles...
  40. The Impact of Ischemia on Alzheimer's Disease
    Maya A Koike; Fiscal Year: 2010
    ..These include ischemic stroke, oligemic incident, traumatic brain injury, hypoxia, cardiac arrest, hyperemia and cerebral blood pressure that is excessively lower or higher than the periphery...
  41. Clinical and Genetic Correlates of Vascular Function in African Americans: JHS
    Ervin R Fox; Fiscal Year: 2013
    ..We will measure (1) flow-mediated brachial artery dilation (FMD) and reactive hyperemia, (2) digital peripheral arterial tonometry (PAT) waveforms, and (3) aortic pulse wave velocity (PWV) and ..
  42. Dual Energy CT Evaluation of Airway Inflammation
    David P Naidich; Fiscal Year: 2012
    ..Key to our hypothesis is the well established fact that inflammation leads to bronchial arterial hyperemia previously requiring either invasive angiography or sophisticated laboratory techniques rarely utilized...
  43. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..seen in the normal coronary circulation and that capillary blood volume decreases distal to a stenosis during hyperemia. We have also shown that perfusion defects on nuclear tracer imaging is related to reversible decreases in MBV ..
  44. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..seen in the normal coronary circulation and that capillary blood volume decreases distal to a stenosis during hyperemia. We have also shown that perfusion defects on nuclear tracer imaging is related to reversible decreases in MBV ..
  45. SPLANCHNIC HEMODYNAMICS IN PORTAL HYPERTENSION
    JAMES SITZMANN; Fiscal Year: 1992
    ..The effect of normalization of portal pressure (portosystemic shunt) on the hyperemia of human portal hypertension will be studied...
  46. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..that, in animals chronically treated with the eNOS inhibitor L-NAME, the contribution of adenosine to metabolic hyperemia is increased...
  47. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ..In Specific Aim 3 we will explore the contribution of adenosine to reactive and metabolic hyperemia, both in normals and in medication-free hyperlipemic patients...
  48. BRONCHIAL CIRCULATION AND LUNG FLUID BALANCE
    George Kramer; Fiscal Year: 1993
    ..circulation; 5) to evaluate the effectiveness of various anti-inflammatory agents and local anesthetics on the hyperemia and permeability alterations of inflammation...
  49. ECHOCARDIOGRAPHIC ASSESSMENT OF MICROVASCULAR PERFUSION
    Kevin Wei; Fiscal Year: 2003
    ..In the presence of exogenous hyperemia, capillaries may collapse in the bed distal to the stenosis...
  50. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2001
    ..Increasing anatomic evidence points to a role for nitric oxide as a mediator of female genital hyperemia, similar to the situation in the male...
  51. MECHANISMS OF PHOSPHOLIPASE A2 REGULATION
    John Bell; Fiscal Year: 1990
    ..Excess PLA2 activity is implicated in a number of diseases including rheumatoid arthritis inflammatory hyperemia, inflammatory problems associated with burns and trauma, eczema, psoriasis, pancreatitis, trypanosomiasis, ..
  52. PREVENTION OF HYPEREMIA & HEMORRHAGE IN NEWBORN BRAIN
    Jan Goddard Finegold; Fiscal Year: 1991
    ..Our studies have shown that a marked increase in brain blood flow is common to these insults, and that such hyperemia is associated with the production of microvascular lesions in the pup brain...
  53. Hormone Replacement Therapy, SERMs & Leg Blood Flow in Postmenopausal Women
    DOUGLAS SEALS; Fiscal Year: 2007
    ..LVC, cardiac output, muscle sympathetic nerve activity, plasma catecholamine concentrations, leg peak reactive hyperemia and VC, measures of local vasodilatory/vasoconstrictor influences (including flow-mediated dilation and vascular ..
  54. CEREBRAL BLOOD FLOW AND METABOLISM DURING INFANT CPR
    Charles Schleien; Fiscal Year: 1990
    ..We will find out if the blood brain barrier is disrupted during CPR or during the cerebral hyperemia that follows cardioversion, or if circulating epinephrine gains entry into the brain by saturating the enzymatic ..
  55. SEVERE DIFFUSE TRAUMATIC BRAIN INJURY
    P David Adelson; Fiscal Year: 2001
    ..closed head injury weight-drop) in immature (17 d) rats; 2) to describe the acute and chronic changes in CBF (hyperemia vs ischemia) and CO2 vasoresponsivity after this injury; and 3) to determine if moderate hypothermia (32 +/- 0...
  56. Exercise Training and Myocardial K-ATP Channel Function
    RUSSELL MOORE; Fiscal Year: 2007
    ..We also observed a marked Tr-induced hyperemia that was apparent throughout the ischemia reperfusion protocol...
  57. SYSTEMATIC STUDY OF THE BRONCHIAL CIRCULATION
    MICHAEL MAGNO; Fiscal Year: 1980
    ..It has also been shown that the bronchial circulation does not show a true reactive hyperemia which may be related to the presence of collaterals or it may indicate that autoregulation of blood flow does ..
  58. Effects of EECP on Arterial Function
    RANDY BRAITH; Fiscal Year: 2006
    ..Specifically, we propose that EECP, by promoting lower extremity arterial "runoff" and intermittent reactive hyperemia in the legs with each inflation/deflation cycle of the compressive cuffs, improves peripheral vascular function...
  59. FUNCTIONAL HYPEREMIA--PERIPHERAL AND CENTRAL INTERACTION
    STEVEN SEGAL; Fiscal Year: 1992
    ..Findings may offer novel methods for treatment of hypertension and ischemic disorders...
  60. REGULATION OF MUSCLE BLOOD FLOW IN OLDER WOMEN AND MEN
    David Proctor; Fiscal Year: 2009
    ..of diminished (hypothesis 3) and enhanced (hypothesis 4A: ischemic handgrip, IHG) sympathetic modulation of leg hyperemia, endothelium-mediated vasodilation during exercise (hypothesis 4B;combined NO/PG blockade), and the interaction ..
  61. Vascular KATP Channel Modulation in Hypercapnic Acidosis
    Chun Jiang; Fiscal Year: 2006
    ..KATP) couple the intermediary metabolism to cellular excitability, and play an important role in reactive hyperemia. It is known that hyperemia underlies the cardio-protective effect of ischemic preconditioning and the activity-..
  62. Age, gender and skeletal muscle microcirculation
    LEAH HAMMER; Fiscal Year: 2004
    ..The increase in skeletal muscle blood flow that accompanies muscle contraction (functional hyperemia) is impaired in aged male rats but is unaltered in aged female rats...
  63. PATHOGENESIS OF CONJUNCTIVITIS IN THE EYE
    SANTA ONO; Fiscal Year: 2000
    ..innocuous substances and suffer from symptoms ranging from mild itching and burning, to chemosis, conjunctival hyperemia, lid edema and at its worst, scarring of the ocular surface and permanent visual impairment...
  64. LOCAL MECHANISMS OF ARTERIOLAR CONTROL IN EXERCISE
    INGRID SARELIUS; Fiscal Year: 2001
    ..We will ask if the response is initiated by mediators commonly implicated in exercise hyperemia. These studies will establish the pathway which directly couples local muscle activity to capillary blood flow, ..
  65. RENAL HEMODYNAMIC ABNORMALITIES IN EARLY DIABETES
    NORMAN BANK; Fiscal Year: 1991
    ..This should also reduce intracellular IP3. Renal hemodynamics will be measured to determine whether hyperemia develops, as it does in diabetes...
  66. NURSING STUDY OF SLEEP AND FIBROMYALGIA IN MIDLIFE WOMEN
    Carol Landis; Fiscal Year: 1999
    ..amplified muscle pain, somatic and psychological distress symptoms and inflammatory or immune changes like hyperemia, NK cell activity suppressions and altered T cell activation markers...