left ventricular dysfunction

Summary

Summary: A condition in which the left ventricle of the heart exhibits a decreased functionality. This decreased function could lead to congestive heart failure or myocardial infarction, among other cardiovascular diseases. Diagnostic measurements that indicate this condition include a diminished ejection fraction and a depressed level of motility of the left ventricular wall.

Top Publications

  1. ncbi Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiograph
    Roberto M Lang
    University of Chicago Hospitals, Chicago, IL, USA
    J Am Soc Echocardiogr 18:1440-63. 2005
  2. ncbi Recommendations for chamber quantification
    Roberto M Lang
    Med Klinik 2, Erlangen University, Ulmenweg 18, 91054 Erlangen, Germany
    Eur J Echocardiogr 7:79-108. 2006
  3. ncbi Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    Bertram Pitt
    University of Michigan, Ann Arbor, USA
    N Engl J Med 348:1309-21. 2003
  4. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  5. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
  6. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
  7. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
  8. ncbi Subclinical left ventricular dysfunction in asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration
    Hiromi Nakai
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Eur J Echocardiogr 10:926-32. 2009
  9. ncbi Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction
    Zoran B Popovic
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 292:H2809-16. 2007
  10. ncbi Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms
    Stefan Hein
    Kerckhoff Clinic, Department of Thoracic and Cardiovascular Surgery, Bad Nauheim, Germany
    Circulation 107:984-91. 2003

Detail Information

Publications334 found, 100 shown here

  1. ncbi Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiograph
    Roberto M Lang
    University of Chicago Hospitals, Chicago, IL, USA
    J Am Soc Echocardiogr 18:1440-63. 2005
  2. ncbi Recommendations for chamber quantification
    Roberto M Lang
    Med Klinik 2, Erlangen University, Ulmenweg 18, 91054 Erlangen, Germany
    Eur J Echocardiogr 7:79-108. 2006
    ..This document reviews the technical aspects on how to perform quantitative chamber measurements of morphology and function, which is a component of every complete echocardiographic examination...
  3. ncbi Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    Bertram Pitt
    University of Michigan, Ann Arbor, USA
    N Engl J Med 348:1309-21. 2003
    ..placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure.
  4. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  5. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
    ..This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes...
  6. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
    ..We evaluated its effects on morbidity and mortality...
  7. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
    ..In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden...
  8. ncbi Subclinical left ventricular dysfunction in asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration
    Hiromi Nakai
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Eur J Echocardiogr 10:926-32. 2009
    ..Subclinical left ventricular (LV) systolic dysfunction may be identified by a reduction in longitudinal function, which can be assessed using 2D speckle tracking echocardiography (STE)...
  9. ncbi Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction
    Zoran B Popovic
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 292:H2809-16. 2007
    ..0001) than on percent fibrosis (P<0.002). STE correctly identifies segmental LV dysfunction induced by scarring that follows myocardial infarction in rats...
  10. ncbi Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms
    Stefan Hein
    Kerckhoff Clinic, Department of Thoracic and Cardiovascular Surgery, Bad Nauheim, Germany
    Circulation 107:984-91. 2003
    ....
  11. ncbi Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan
    K Tsuchihashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    J Am Coll Cardiol 38:11-8. 2001
    ....
  12. pmc Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction
    Andre Schmidt
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:2006-14. 2007
    ....
  13. ncbi Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
    ..Further, diastolic function is seldom systematically assessed based on standardized techniques...
  14. ncbi The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    James C C Moon
    Centre for Advanced Magnetic Resonance in Cardiology CAMRIC, London, United Kingdom
    J Am Coll Cardiol 43:2260-4. 2004
    ..We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM)...
  15. ncbi Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
    ..It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven...
  16. ncbi Noninvasive estimation of left ventricular filling pressure by E/e' is a powerful predictor of survival after acute myocardial infarction
    Graham S Hillis
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Am Coll Cardiol 43:360-7. 2004
    ..The aim of this study was to assess the prognostic value of a noninvasive measure of left ventricular diastolic pressure (LVDP) early after acute myocardial infarction (MI)...
  17. pmc Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population
    T A McDonagh
    Department of Medical Cardiology, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Heart 86:21-6. 2001
    ....
  18. ncbi Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial
    H J Dargie
    Department of Cardiology, Western Infirmary, G11 2NT, Glasgow, UK
    Lancet 357:1385-90. 2001
    ..We investigated the long-term efficacy of carvedilol on morbidity and mortality in patients with left-ventricular dysfunction after acute myocardial infarction treated according to current evidence-based practice...
  19. ncbi A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction
    Matthias Manz
    Department of Cardiology, Marienhof Hospital, Koblenz, Germany
    Cardiology 100:149-55. 2003
    ..Thus, a single intravenous dose of ivabradine produced a substantial reduction in resting heart rate without affecting LV function in patients with regional or global LV dysfunction...
  20. pmc Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    Stem Cells 26:1646-55. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  21. ncbi Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms
    Cecilia Linde
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    J Am Coll Cardiol 52:1834-43. 2008
    ....
  22. pmc Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction
    Xian Liang Tang
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 121:293-305. 2010
    ..Therefore, we sought to determine whether CPCs are beneficial in the more clinically relevant setting of an old MI (scar)...
  23. ncbi Mechanical dyssynchrony after myocardial infarction in patients with left ventricular dysfunction, heart failure, or both
    Sung Hee Shin
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 121:1096-103. 2010
    ..Mechanical dyssynchrony is considered an independent predictor for adverse cardiovascular outcomes in patients with heart failure. However, its importance as a risk factor after myocardial infarction is not well defined...
  24. ncbi Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function
    Marina Leitman
    Cardiology Department, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    J Am Soc Echocardiogr 17:1021-9. 2004
    ..We sought to assess the feasibility of 2-dimensional strain, a novel software for real-time quantitative echocardiographic assessment of myocardial function...
  25. ncbi Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction
    Mei Sun
    Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, and University Health Network, Toronto, Ontario, Canada
    Circulation 110:3221-8. 2004
    ....
  26. ncbi Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 113:969-76. 2006
    ..In the present study, the relationship between transmural posterolateral scar tissue and response to CRT was evaluated...
  27. ncbi Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction
    Iain B Squire
    Department of Medicine and Therapeutics, University of Leicester, Leicester, United Kingdom
    J Card Fail 10:328-33. 2004
    ..The aims of this study were to investigate plasma MMP-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 concentrations following acute myocardial infarction and their relationships with measures of left ventricular function...
  28. ncbi Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay
    S Cazeau
    InParys, Saint-Cloud, France
    N Engl J Med 344:873-80. 2001
    ..001). CONCLUSIONS: Although it is technically complex, atriobiventricular pacing significantly improves exercise tolerance and quality of life in patients with chronic heart failure and intraventricular conduction delay...
  29. ncbi Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia
    Ling Chen
    Div of Pulmonary and Critical Care Medicine, Univ of Maryland, Baltimore, 685 West Baltimore St, MSTF 816, Baltimore, MD 21201, USA
    J Appl Physiol (1985) 104:218-23. 2008
    ..In conclusion, CIH-mediated LV global dysfunction is associated with myocyte hypertrophy and apoptosis at the cellular level...
  30. ncbi Brain natriuretic peptide based strategy to detect left ventricular dysfunction in Chagas disease: a comparison with the conventional approach
    Antonio Luiz P Ribeiro
    Postgraduate Course of Tropical Medicine, Internal Medicine Department, School of Medicine, Federal University of Minas Gerais, Av Alfredo Balena, 190 Campus Saúde, 30130 100, Belo Horizonte, Brazil
    Int J Cardiol 109:34-40. 2006
    b>Left ventricular dysfunction (LVd) is the main predictor of mortality in Chagas disease (ChD).
  31. ncbi Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    N Engl J Med 346:877-83. 2002
    ..This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients...
  32. ncbi Racial differences in the outcome of left ventricular dysfunction
    D L Dries
    Clinical Trials Scientific Research Group, Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7936, USA
    N Engl J Med 340:609-16. 1999
    ..Although these factors probably account for some of the higher mortality due to congestive heart failure among blacks, we hypothesized that racial differences in the natural history of left ventricular dysfunction might also have a role.
  33. ncbi Prognostic significance of delayed-enhancement magnetic resonance imaging: survival of 857 patients with and without left ventricular dysfunction
    Benjamin Y C Cheong
    Department of Diagnostic and Interventional Radiology, St Luke s Episcopal Hospital and the Texas Heart Institute, 6720 Bertner Ave, MC 2 270, Houston, TX 77030, USA
    Circulation 120:2069-76. 2009
    ..To date, relatively limited data are available on the prognostic value of DE-MRI, so we sought to determine whether DE-MRI findings independently predict survival...
  34. ncbi Circumferential and longitudinal strain in 3 myocardial layers in normal subjects and in patients with regional left ventricular dysfunction
    Marina Leitman
    Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, Israel
    J Am Soc Echocardiogr 23:64-70. 2010
    ..The aim of this study was to analyze strain in 3 myocardial layers using speckle-tracking echocardiography...
  35. ncbi Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction
    A Luchner
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg, F J Strauss Allee 11, 93042, Regensburg, Germany
    Cardiovasc Res 51:601-7. 2001
    ....
  36. ncbi Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy
    Denis Duboc
    French Working Group of Heart Involvement in Myopathies Investigators, Paris, France
    J Am Coll Cardiol 45:855-7. 2005
    ..The aim of this research was to examine the effects of perindopril on cardiac function in patients with Duchenne muscular dystrophy (DMD)...
  37. ncbi Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis
    Volkhard Kurowski
    Medical Clinic II, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Chest 132:809-16. 2007
    ..The frequency and potential differences between patients with apical ("typical") and midventricular ("atypical") ballooning have not been described...
  38. ncbi Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity
    Patrick W Fisher
    Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University Medical Center, Richmond 23298, USA
    Circulation 111:1601-10. 2005
    ..It is unclear whether sildenafil would provide similar protection from doxorubicin-induced cardiotoxicity...
  39. ncbi Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and/or left ventricular dysfunction: a VALIANT study
    Eldrin F Lewis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 29:748-56. 2008
    ..We sought to assess the incidence of and prognostic factors for heart failure (HF) hospitalization among survivors of high-risk acute myocardial infarction (MI)...
  40. ncbi Validation of echocardiographic two-dimensional speckle tracking longitudinal strain imaging for viability assessment in patients with chronic ischemic left ventricular dysfunction and comparison with contrast-enhanced magnetic resonance imaging
    Stijntje D Roes
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 104:312-7. 2009
    ..A cutoff value of -4.5% for regional strain discriminated between segments with viable myocardium and those with transmural scar tissue on contrast-enhanced MRI with a sensitivity of 81.2% and specificity of 81.6%...
  41. ncbi Diabetic cardiomyopathy: the search for a unifying hypothesis
    Indu G Poornima
    Department of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circ Res 98:596-605. 2006
    ..The recent recognition that diabetes involves more than abnormal glucose homeostasis provides important new opportunities to examine and understand the impact of complex metabolic disturbances on cardiac structure and function...
  42. ncbi Dialysis-induced regional left ventricular dysfunction is ameliorated by cooling the dialysate
    Nicholas M Selby
    Department of Renal Medicine, Derby City Hospital, Derby, UK
    Clin J Am Soc Nephrol 1:1216-25. 2006
    ..This study confirms previous findings of reversible LV RWMA that develop during hemodialysis. It also shows that this phenomenon can be ameliorated by reducing dialysate temperature, a simple intervention with no cost implications...
  43. pmc Circulating heat shock proteins and inflammatory markers in patients with idiopathic left ventricular dysfunction: their relationships with myocardial and microvascular impairment
    Daniela Giannessi
    Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa 56100, Italy
    Cell Stress Chaperones 12:265-74. 2007
    ..These results suggest a pathogenic role of infective-metabolic insult and inflammatory reaction in the development of vascular and myocardial damage in patients with heart failure even in the absence of overt coronary artery disease...
  44. ncbi Fragmented QRS and mortality risk in patients with left ventricular dysfunction
    Aamir Cheema
    Mid America Heart Institute and the University of Missouri, Kansas City, MO, USA
    Circ Arrhythm Electrophysiol 3:339-44. 2010
    ..Whether fQRS improves patient selection for primary prevention patients eligible for implantable cardioverter-defibrillator (ICD) therapy remains unknown...
  45. ncbi Diuretic use, progressive heart failure, and death in patients in the Studies Of Left Ventricular Dysfunction (SOLVD)
    Michael Domanski
    Clinical Trials Group, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7936, USA
    J Am Coll Cardiol 42:705-8. 2003
    ..We sought to determine whether non-potassium-sparing diuretics (PSDs) in the absence of a PSD may result in progressive heart failure (HF)...
  46. ncbi High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction
    Uwe Kuhl
    Charite University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 111:887-93. 2005
    ....
  47. pmc Diastolic dysfunction and diastolic heart failure: diagnostic, prognostic and therapeutic aspects
    Maurizio Galderisi
    Division of Cardioangiology, CCU Department of Clinical and Experimental Medicine, Federico II University, Medical School Napoli, Italy
    Cardiovasc Ultrasound 3:9. 2005
    ..Several trials, completed or ongoing, have been planned to treat DD and diastolic HF...
  48. ncbi "Indeterminate" microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction
    Elizabeth S Kaufman
    Heart and Vascular Research Center, MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Am Coll Cardiol 48:1399-404. 2006
    ..This study tested the hypothesis that an "indeterminate" microvolt T-wave alternans (MTWA) test, when due to ectopy, unsustained MTWA, or low exercise heart rate (HR), has prognostic significance similar to a positive MTWA test...
  49. ncbi Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 352:2581-8. 2005
    ..We assessed the risk and time course of sudden death in high-risk patients after myocardial infarction...
  50. ncbi Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus
    John K Boyer
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Cardiol 93:870-5. 2004
    ..TDI markedly improved the echocardiographic detection of diastolic dysfunction in asymptomatic patients with type 2 diabetes...
  51. ncbi QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: a prospective study
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, Universita La Sapienza, Viale del Policlinico, 00161 Rome, Italy
    Eur Heart J 28:1344-50. 2007
    ..We assessed whether the indices of QT variability from a short-term electrocardiographic (ECG) recording predict sudden death...
  52. ncbi Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    Michael R Bristow
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 350:2140-50. 2004
    ....
  53. pmc Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in the general community: determinants and detection of left ventricular dysfunction
    Lisa C Costello-Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 47:345-53. 2006
    ..This study sought to characterize factors influencing amino-terminal pro-B-type natriuretic peptide (NT-proBNP) and to evaluate the ability of NT-proBNP to detect left ventricular (LV) dysfunction in a large community sample...
  54. ncbi Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review
    Monica Gianni
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    Eur Heart J 27:1523-9. 2006
    ..To clarify the major features of the apical ballooning syndrome, we performed a systematic review of the existing literature...
  55. pmc Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice
    Theodore P Abraham
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Cardiovasc Res 82:84-92. 2009
    ....
  56. ncbi Ampulla cardiomyopathy ('Takotusbo' cardiomyopathy)--reversible left ventricular dysfunction: with ST segment elevation
    S Kawai
    Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
    Jpn Circ J 64:156-9. 2000
    ..The presence of myocardial lesions suggested that focal and disseminated myocardial damage had occurred...
  57. ncbi Cardiac dysfunction assessed by echocardiographic tissue Doppler imaging is an independent predictor of mortality in the general population
    Rasmus Mogelvang
    Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    Circulation 119:2679-85. 2009
    Tissue Doppler imaging (TDI) detects left ventricular dysfunction in patients with heart failure and normal ejection fraction, but the prognostic significance of left ventricular dysfunction by TDI in the general population is unknown.
  58. ncbi Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging
    Yuichi Notomi
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 45:2034-41. 2005
    ....
  59. ncbi Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials. Studies of Left Ventric
    D L Dries
    Clinical Trials Scientific Research Group, The National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    J Am Coll Cardiol 32:695-703. 1998
    ..to determine if the presence of atrial fibrillation in patients with asymptomatic and symptomatic left ventricular dysfunction was associated with increased mortality and, if so, whether the increase could be attributed to ..
  60. ncbi Metabolic syndrome is associated with abnormal left ventricular diastolic function independent of left ventricular mass
    Lisa De Las Fuentes
    Cardiovascular Imaging and Clinical Research Core Laboratory, Campus Box 8086, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Eur Heart J 28:553-9. 2007
    ..To characterize the extent to which metabolic syndrome criteria predict left ventricular (LV) structure and function...
  61. ncbi Two-dimensional strain--a Doppler-independent ultrasound method for quantitation of regional deformation: validation in vitro and in vivo
    Josef Korinek
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 18:1247-53. 2005
    ..We compared strains measured in vitro and in vivo by 2DSE with those obtained by sonomicrometry...
  62. ncbi Prevalence of left ventricular diastolic dysfunction in the community. Results from a Doppler echocardiographic-based survey of a population sample
    M Fischer
    Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, Franz Josef Strauss Allee 11, Germany
    Eur Heart J 24:320-8. 2003
    ....
  63. ncbi Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
    Martin G St John Sutton
    Division of Cardiology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Circulation 107:1985-90. 2003
    ..The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT...
  64. ncbi Central sleep apnea in left ventricular dysfunction: prevalence and implications for arrhythmic risk
    Paola A Lanfranchi
    Division of Cardiology, Fondazione Salvatore Maugeri IRCCS, Veruno, Italy
    Circulation 107:727-32. 2003
    ....
  65. ncbi Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus
    D Westermann
    Department of Cardiology and Pneumology, Charite University Hospital, Benjamin Franklin Campus, Berlin, Germany
    Diabetologia 49:2507-13. 2006
    ..We investigated the effect of SB 203580, a pharmacological inhibitor of p38 mitogen-activated protein kinase (MAPK), on cardiac inflammation, cardiac fibrosis, and left ventricular function using an animal model of diabetic cardiomyopathy...
  66. ncbi Utility of B-type natriuretic peptide (BNP) as a screen for left ventricular dysfunction in patients with diabetes
    Victoria Epshteyn
    Department of Medicine, Veteran s Affairs Medical Center, San Diego, California 92161, USA
    Diabetes Care 26:2081-7. 2003
    ..B-type natriuretic peptide (BNP) is secreted from the left ventricle in response to pressure overload and is elevated in both systolic and diastolic dysfunction...
  67. ncbi Gender differences in clinical outcome and primary prevention defibrillator benefit in patients with severe left ventricular dysfunction: a systematic review and meta-analysis
    Pasquale Santangeli
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    Heart Rhythm 7:876-82. 2010
    ..Women are underrepresented in primary prevention implantable cardioverter-defibrillator (ICD) trials, and data on the benefit of ICD therapy in this subgroup are controversial...
  68. ncbi Magnetic resonance assessment of aortic pulse wave velocity, aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus
    Rutger W van der Meer
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Magn Reson 9:645-51. 2007
    ..Furthermore, CMR is a reliable method for assessing left ventricular (LV) function. The purpose of this study was to assess LV function, PWV, and aortic distensibility in patients with DM2 using MR...
  69. ncbi Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
    Alan S Maisel
    University of California, San Diego, Veterans Affairs Medical Center, San Diego 92161, USA
    N Engl J Med 347:161-7. 2002
    ..B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension...
  70. pmc Differences in the incidence of congestive heart failure by ethnicity: the multi-ethnic study of atherosclerosis
    Hossein Bahrami
    Division of Cardiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    Arch Intern Med 168:2138-45. 2008
    ..Our objective was to evaluate the relationship between race/ethnicity and incident CHF...
  71. ncbi Circulating endothelial microparticles correlate inversely with endothelial function in patients with ischemic left ventricular dysfunction
    Daniel Bulut
    Herzzentrum der Kliniken der Ruhr Universität Bochum, Standort St Josef Hospital, Gudrunstrasse 56, 44791 Bochum, Germany
    J Card Fail 14:336-40. 2008
    ..The patients were divided in 2 groups, those with preserved or normal function (n = 17; EF 65 +/- 6%) and those with reduced left ventricular (LV) function (n = 18; EF 36 +/- 11%)...
  72. ncbi Neopterin levels and left ventricular dysfunction in patients with chronic stable angina pectoris
    Rodrigo Estévez-Loureiro
    Cardiovascular Biology Research Centre, Division of Cardiac and Vascular Sciences, St George s, University of London, London, UK
    Atherosclerosis 207:514-8. 2009
    ..We therefore sought to investigate whether C reactive protein (CRP) and neopterin correlate with LV dysfunction in patients with CSA...
  73. ncbi Effect of revascularization on long-term survival in patients with ischemic left ventricular dysfunction and a wide range of viability
    Stephen G Sawada
    Krannert Institute of Cardiology, Department of Medicine, Indiana University Medical Center, Indianapolis, IN, USA
    Am J Cardiol 106:187-92. 2010
    Short-term survival in patients with viability and ischemic left ventricular dysfunction appears improved by revascularization, but no randomized studies have shown a long-term benefit of revascularization in patients with a wide range of ..
  74. ncbi Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction
    Kevin A Bybee
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Ann Intern Med 141:858-65. 2004
    ..pain, relatively minor elevation of cardiac enzyme and biomarker levels, and transient apical systolic left ventricular dysfunction despite the absence of obstructive epicardial coronary disease...
  75. pmc Changes in diastolic dysfunction in diabetes mellitus over time
    Aaron M From
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Cardiol 103:1463-6. 2009
    ..LV diastolic dysfunction is predictive of all-cause mortality in patients with DM independent of hypertension and coronary disease...
  76. pmc Echocardiography-based left ventricular mass estimation. How should we define hypertrophy?
    Murilo Foppa
    Graduate Studies Program in Cardiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre RS, Brazil
    Cardiovasc Ultrasound 3:17. 2005
    ....
  77. ncbi Gender related differential effects of Omega-3E treatment on diabetes-induced left ventricular dysfunction
    Erkan Tuncay
    Department of Biophysics, School of Medicine, Ankara University, Ankara, Turkey
    Mol Cell Biochem 304:255-63. 2007
    ..Present data show that there are gender related differences in diabetic heart dysfunction and the response to antioxidant treatment...
  78. ncbi F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2)
    Rob S B Beanlands
    National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 50:2002-12. 2007
    ..We conducted a randomized trial to assess the effectiveness of F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-assisted management in patients with severe ventricular dysfunction and suspected coronary disease...
  79. ncbi Diagnostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for left ventricular dysfunction in patients with chronic kidney disease stage 5 on haemodialysis
    Sascha David
    Department of Nephrology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nephrol Dial Transplant 23:1370-7. 2008
    ..N-terminal pro-B-type natriuretic peptide (NT-proBNP) have become increasingly important in diagnosing left ventricular dysfunction (LVD), however, in patients with chronic kidney disease (CKD), their use is confounded by concomitant ..
  80. doi Stunning, hibernation, and assessment of myocardial viability
    Paolo G Camici
    Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 117:103-14. 2008
  81. ncbi Echocardiographic indices of increased left ventricular filling pressure and dilation after acute myocardial infarction
    Graham S Hillis
    Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 19:450-6. 2006
    ..These data suggest that the E/e' ratio may be a useful predictor of LV dilation after acute myocardial infarction. In particular, an E/e' ratio greater than 15 identifies patients at increased risk...
  82. ncbi Natural history of asymptomatic left ventricular systolic dysfunction in the community
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 108:977-82. 2003
    ..We sought to characterize the natural history of ALVD, by studying unselected individuals with this condition in the community...
  83. ncbi Co-existence of COPD and left ventricular dysfunction in vascular surgery patients
    Willem Jan Flu
    Department of Anaesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Respir Med 104:690-6. 2010
    ..This study determined the relationship and clinical relevance of COPD and subclinical LV dysfunction in vascular surgery patients...
  84. ncbi Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophic cardiomyopathy
    Toru Kubo
    Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan
    Clin Cardiol 33:E1-7. 2010
    ..Serum cardiac troponin I (cTnI) is a sensitive and specific marker of myocardial injury. However, a systematic evaluation of cTnI in hypertrophic cardiomyopathy (HCM) patients has not been performed...
  85. ncbi Does cardioplegia type affect outcome and survival in patients with advanced left ventricular dysfunction? Results from the CABG Patch Trial
    J E Flack
    Department of Surgery, Baystate Medical Center, Springfield, MA, USA
    Circulation 102:III84-9. 2000
    ..The CABG Patch Trial enrolled a high-risk group of coronary artery disease patients with an ejection fraction of <36%. Thus, they constitute an ideal group to benefit most from optimal cardioplegic protection...
  86. ncbi Prevention of disease progression by cardiac resynchronization therapy in patients with asymptomatic or mildly symptomatic left ventricular dysfunction: insights from the European cohort of the REVERSE (Resynchronization Reverses Remodeling in Systolic Le
    Claude Daubert
    Departement de Cardiologie et Maladies Vasculaires, CHU, Rennes, France
    J Am Coll Cardiol 54:1837-46. 2009
    ..study was to determine the long-term effects of cardiac resynchronization therapy (CRT) in the European cohort of patients enrolled in the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) trial.
  87. pmc TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction
    Nithya Mariappan
    Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA
    Free Radic Biol Med 46:462-70. 2009
    ....
  88. ncbi Previously known and newly diagnosed atrial fibrillation: a major risk indicator after a myocardial infarction complicated by heart failure or left ventricular dysfunction
    Lars Køber
    Department of Cardiology, Non Invasive Lab, Rigshospitalet, 9 Blegdamsvej, Copenhagen, Denmark
    Eur J Heart Fail 8:591-8. 2006
    ....
  89. pmc Alterations in transmural myocardial strain: an early marker of left ventricular dysfunction in mitral regurgitation?
    Carl J Carlhäll
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305 5247, USA
    Circulation 118:S256-62. 2008
    ..We hypothesized that changes in LV transmural myocardial strain represent an early marker of LV dysfunction in an ovine chronic MR model...
  90. ncbi The relation between quantitative right ventricular ejection fraction and indices of tricuspid annular motion and myocardial performance
    Darryl Miller
    University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Am Soc Echocardiogr 17:443-7. 2004
    ..Assessment of right ventricular (RV) function remains challenging because of complex RV chamber geometry and a paucity of easily derived and objective functional methods...
  91. ncbi Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 351:2481-8. 2004
    ..Whether benefit occurs in patients early after myocardial infarction is unknown...
  92. ncbi Deteriorating glucose tolerance status is associated with left ventricular dysfunction--the Hoorn Study
    R M A Henry
    Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Neth J Med 66:110-7. 2008
    ..We investigated, in a population-based cohort (n=746), the association between glucose tolerance status and SDF and DDF ...
  93. ncbi Usefulness of abnormal heart rate turbulence to predict cardiovascular mortality in high-risk patients with acute myocardial infarction and left ventricular dysfunction (from the EPHESUS study)
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri, USA
    Am J Cardiol 103:1495-9. 2009
    ..Holter monitoring in 481 hospitalized patients after AMI with heart failure and/or diabetes with left ventricular dysfunction before randomization in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and ..
  94. ncbi Cardiomyoblast-like cells differentiated from human adipose tissue-derived mesenchymal stem cells improve left ventricular dysfunction and survival in a rat myocardial infarction model
    Hanayuki Okura
    Department of Somatic Stem Cell Therapy, Foundation for Biomedical Research and Innovation, Kobe, Japan
    Tissue Eng Part C Methods 16:417-25. 2010
    ..Thus, transplantation of hCLC patches is a potentially effective therapeutic strategy for future cardiac tissue regeneration...
  95. ncbi Aortic elasticity and size are associated with aortic regurgitation and left ventricular dysfunction in tetralogy of Fallot after pulmonary valve replacement
    H B Grotenhuis
    Department of Radiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Heart 95:1931-6. 2009
    ..Aortic wall pathology and concomitant aortic dilatation have been described in tetralogy of Fallot (TOF) patients, which may negatively affect aortic valve and left ventricular systolic function...
  96. ncbi Aortic arch calcification and arterial stiffness are independent factors for diastolic left ventricular dysfunction in chronic hemodialysis patients
    Ayuko Fujiu
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Circ J 72:1768-72. 2008
    ....
  97. ncbi Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction
    S R Mehta
    Division of Cardiology, Hamilton Health Sciences Corporation, McMaster University, Ontario, Canada
    J Am Coll Cardiol 37:37-43. 2001
    ..We sought to evaluate the prognostic impact of right ventricular (RV) myocardial involvement in patients with inferior myocardial infarction (MI)...
  98. ncbi Iodine-123 metaiodobenzylguanidine imaging and carbon-11 hydroxyephedrine positron emission tomography compared in patients with left ventricular dysfunction
    Ichiro Matsunari
    The Medical and Pharmacological Research Center Foundation, Hakui, Japan
    Circ Cardiovasc Imaging 3:595-603. 2010
    ....
  99. ncbi High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction
    Julie H Rennison
    Dept of Physiology and Biophysics, School of Medicine E558, Case Western Reserve Univ, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 292:H1498-506. 2007
    ....
  100. ncbi Early detection of left ventricular dysfunction with strain imaging in thalassemia patients
    Ahmet Kaya Bilge
    Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Clin Cardiol 33:E29-34. 2010
    ..The aim of this study is to evaluate left ventricular (LV) functions by tissue velocity imaging (TVI) and strain imaging (SI) in thalassemia patients without overt heart failure...
  101. ncbi Pathogenesis of sudden unexpected death in a clinical trial of patients with myocardial infarction and left ventricular dysfunction, heart failure, or both
    Anne Catherine Pouleur
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 122:597-602. 2010
    ....

Research Grants65

  1. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2003
    DESCRIPTION (Adapted from the applicant's abstract):Left ventricular dysfunction (LVD) is a syndrome which presents as dyspnea on exertion, wheezing, a rapid respiratory rate, and increased secretion of mucus...
  2. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..Infusion/treatment of mice with salubrinal reduced the extent of 2-AR-stimulated and MI-induced left ventricular dysfunction and cardiac myocyte apoptosis in the heart...
  3. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..strategies whose administration at the time of acute myocardial infarction might reduce post-ischemic left ventricular dysfunction and favorably improve long-term outcomes, such as heart failure and cardiac sudden death...
  4. Extracellular ubiquitin: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2010
    ..Infusion of mice with exogenous ubiquitin inhibited ?AR-stimulated left ventricular dysfunction, cardiac myocyte apoptosis and myocardial fibrosis in mice...
  5. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
  6. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
  7. Cardioprotective Signaling following Phosphodiesterase-5 Inhibition
    Rakesh C Kukreja; Fiscal Year: 2012
    ..The most common long-term complication of AMI is the late occurrence of left ventricular dysfunction and heart failure...
  8. The Role of RAGE in Diabetes and Myocardial Infarction.
    KAREN O'SHEA; Fiscal Year: 2013
    ..We will assess differences in I/R-induced left ventricular dysfunction due to genetic strain by echocardiography...
  9. In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRS
    Adil Bashir; Fiscal Year: 2013
    ..evidence that a mismatch in myocardial energy supply and demand contributes to the development of left ventricular dysfunction. Heart uses chemical energy in the form of adenosine triphosphate (ATP) to support systolic and ..
  10. Directing Stem Cell Differentiation on Biologically Inspired Micropatterned Surfa
    Anita Shukla; Fiscal Year: 2012
    ..have shown promise in the treatment of a variety of diseases, including osteogenesis imperfecta and left ventricular dysfunction. Better understanding of hMSC lineage commitment will allow the development of superior regenerative ..
  11. Fundamental Biology of SCD and its Application to Identify Patients at Risk
    GORDON FRANK TOMASELLI; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): More than 5 million people in the United States alone have advanced left ventricular dysfunction with an increased risk of dying suddenly and by current guidelines are candidates for implantable ..
  12. UFCC for Cardiovascular Cell Therapy Research Network
    Carl J Pepine; Fiscal Year: 2011
    ..The two UFCC protocols propose to develop cell therapy for CAD patients with left ventricular dysfunction/heart failure using direct intramural implantation by percutaneous catheter...
  13. Amplification of Cardiosphere-Derived Cell Therapy
    BRIAN RAYMOND WEIL; Fiscal Year: 2013
    ..cells from older adults, ultimately leading to the development of novel strategies to optimize cardiac repair and prevent the progression of left ventricular dysfunction to clinical heart failure in patients wth coronary artery disease.
  14. Computational Tools to Describe Cardiac Post-MI Structure and Function Remodeling
    Siamak Ardekani; Fiscal Year: 2012
    ..For example, in patients with coronary artery disease and left ventricular dysfunction, ventricular remodeling results in a gradual increase of ventricular end-diastolic and end- systolic ..
  15. Electro-mechanical Resynchronization Therapy For Arrhythmogenic Right Ventricular
    Harikrishna Tandri; Fiscal Year: 2012
    ..Recent studies have highlighted the role of dyssynchrohous electrical activation in left ventricular dysfunction associated with LBBB, and for this disorder, bi-ventricular pacing or cardiac resynchronization therapy ..
  16. The molecular mechanisms underlying arrhythmogenic right ventricular dysplasia/ca
    Farah Sheikh; Fiscal Year: 2013
    ..is a genetic form of cardiomyopathy, which is typically characterized by right but also recently left ventricular dysfunction, fibrotic/fatty replacement of the ventricle and ventricular arrhythmias leading to sudden cardiac ..
  17. ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPS
    SUSAN S REDLINE; Fiscal Year: 2013
    ..For example, African Americans have a considerably higher prevalence of hypertension, left ventricular dysfunction, and heart failure than Caucasians despite lipid patterns and coronary artery calcium levels that ..
  18. Exercise and TZD Effects on Myocardial Substrate Metabolism and Function in HIV
    William Todd Cade; Fiscal Year: 2010
    ..myocardial glucose utilization and elevated peripheral and myocardial FFA oxidation is associated with left ventricular dysfunction. Furthermore, both GET and TZD treatment will improve ventricular function through an increase of ..
  19. Cellular Cardiomyoplasty for Chronic Heart Failure
    Joshua M Hare; Fiscal Year: 2013
    ..the potential to regenerate new myocardium and decrease progression of heart failure in patients with left ventricular dysfunction due to healed myocardial infarction...
  20. Data Coordinating Center for VEST and PREDICTS
    Stephen B Hulley; Fiscal Year: 2010
    ..vest will reduce overall mortality during the first 60 days following an Ml in patients with left ventricular dysfunction (EF<35%)...
  21. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    ..Such left ventricular dysfunction often leads to congestive heart failure which results in substantial part from efforts of the heart to ..
  22. Xanthine Oxidase and Bioenergetic Function in Volume Overload
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Mechanisms of left ventricular dysfunction in models of volume overload are not well understood and there is currently no recommended medical ..
  23. Clinical and Genetic Evaluation of Donors for Cardiac Transplantation
    KIRAN KAUR KHUSH; Fiscal Year: 2013
    ..the resources available at Stanford University to identify clinical and genetic risk factors for graft left ventricular dysfunction (Aim 1), to identify donor clinical and genetic predictors of poor recipient outcomes after ..
  24. Probing the Atrial Arrhythmogenic Substrate with Sustained Adrenergic Stimulation
    Brian R Overholser; Fiscal Year: 2013
    ..Specific Aim 2 will test electrophysiological mechanisms for atrial arrhythmogenesis during left ventricular dysfunction by assessing the interplay of focal triggers and reentrant mechanisms...
  25. Nkx2.5-dependent pathways in postnatal cardiomyocytes
    Hideko Kasahara; Fiscal Year: 2009
    ..5 cause progressive conduction defects, various cardiac anomalies and occasional left ventricular dysfunction suggesting that this transcription factor plays important roles in formation of the developing heart as ..
  26. Delayed-Enhancement Cardiac MRI: Prognostic Implications and Improved Imaging
    Raymond J Kim; Fiscal Year: 2013
    ..We propose to study patients with left ventricular dysfunction due to cardiomyopathy, a group at increased risk for sudden death (Aim 1)...
  27. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ..S. One important determinant of early and late mortality is the extent of left ventricular dysfunction. Although early reperfusion by either pharmacologic or mechanical means has been conclusively shown to ..
  28. Subclinical Atherosclerosis in HIV plus Black Cocaine Users
    Shenghan Lai; Fiscal Year: 2013
    ..will investigate why HIV-infected African Americans have high rates of cardiac steatosis and regional left ventricular dysfunction. The study could provide critical information for understanding the mechanisms of premature heart ..
  29. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2002
    ..with the immediate transition from MV to SpV due to hemodynamic instability caused by pre-existing left ventricular dysfunction. The purpose of this study is to examine interventions to optimize the cardiopulmonary (CP) hemodynamic ..
  30. Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine
    Michael Argenziano; Fiscal Year: 2013
    ..benefits of optimized perioperative biventricular pacing (BiVP) versus no pacing (NoP) in patients with left ventricular dysfunction and intraventricular conduction delay undergoing open heart surgery (OHS)...
  31. Angiogenesis in a model of diabetes and endothelial dysfunction
    Frank Sellke; Fiscal Year: 2009
    ..factor (VEGF) and fibroblast growth factor-2 (FGF-2), which has been shown to improve coronary flow and left ventricular dysfunction in numerous animal models, is a particularly attractive therapeutic option for diabetic patients with ..
  32. Aging and Heart Failure are not Similar Syndromes of Sympathetic Dysregulation
    MICHAEL KENNEY; Fiscal Year: 2009
    ..nerve discharge (SND) responses to acute stress in young and old rats with the same degree of left ventricular dysfunction and congestive HF, despite evidence demonstrating diversity in mechanisms regulating physiological ..
  33. REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Julius Guccione; Fiscal Year: 1999
    The global left ventricular dysfunction that is characteristic of left ventricular aneurysm (LVA) is associated with stretching of muscle fibers in the adjacent noninfarcted (border zone) region during isovolumic systole...
  34. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2002
    ..Quantification of gene expression of angiogenic factors, mediators of inflammation, and markers of left ventricular dysfunction will be performed by Real Time PCR on the endomyocardial biopsy samples...
  35. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2004
    ..Quantification of gene expression of angiogenic factors, mediators of inflammation, and markers of left ventricular dysfunction will be performed by Real Time PCR on the endomyocardial biopsy samples...
  36. Neurohormonal Blockade and Outcomes in Diastolic Heart Failure
    Ali Ahmed; Fiscal Year: 2010
    ..We base our hypothesis on the observations that despite differences in nature of left ventricular dysfunction, the pathogenesis (including neurohormonal activation), clinical presentation, and outcomes in systolic ..
  37. SOFTWARE EFFECT ON PROMOTING ADHERENCE TO CHF GUIDELINES
    Lawrence Baruch; Fiscal Year: 2005
    ..infarction, and beta-blockers and angiotensin converting enzyme inhibitors in patients with systolic left ventricular dysfunction. In addition to being underutilized, even when beta-blockers and angiotensin converting enzyme ..
  38. Cardiac Parasympathetic Effect in Exercise and Recovery
    Jeffrey Goldberger; Fiscal Year: 2006
    ..effect on recovery of heart rate and QT interval in subjects with coronary artery disease and left ventricular dysfunction -- this will be assessed by serial exercise tests with and without parasympathetic blockade; c) a new ..
  39. Novel approaches to ischemic tissue repair
    Raj Kishore; Fiscal Year: 2012
    ..insertion, patients with congestive heart failure (CHF) are optimized in medical treatment and, if the left ventricular dysfunction is secondary to ischemia, revascularization, consisting of bypass surgery and/or percutaneous ..
  40. PHYSIOLOGIC BENEFITS OF BIVENTRICULAR PACING IN CHF
    Mohamed Hamdan; Fiscal Year: 2002
    ..Acute biventricular (BV) pacing has been shown to result in hemodynamic improvement in patients with left ventricular dysfunction. Based on these studies, the effect of long term BV pacing on exercise tolerance and quality of life ..
  41. Labeled inhibitors for angiotensin converting enzyme
    John Babich; Fiscal Year: 2004
    ..Heart failure is associated with poor morbidity and mortality; the more severe the clinical failure and left ventricular dysfunction, the worse the prognosis...
  42. ASSESSMENT OF DIASTOLIC FUNCTION IN HUMANS
    James Thomas; Fiscal Year: 1999
    ..is critically important to produce systolic blunting of pulmonary venous flow observed in significant left ventricular dysfunction and systolic reversal in severe mitral regurgitation; 3) mitral inertance varies by disease state, ..
  43. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..of these adverse outcomes are related to the cardiac consequences of the infarct itself, namely left ventricular dysfunction, cardiogenic shock, and congestive heart failure; in spite of the fact that indices of infarct size ..
  44. PREVALENCE OF ASYMPTOMATIC VENTRICULAR DYSFUNCTION
    Richard Rodeheffer; Fiscal Year: 2004
    ..measure cardiac function in a community cohort, to define and characterize the natural history of left ventricular dysfunction (LVD), and to develop means for early detection of LVD...
  45. STATISTICAL PROBLEMS IN MULTIVARIATE SURVIVAL ANALYSIS
    Jianwen Cai; Fiscal Year: 2001
    ..Software will be developed. Data from the Studies of Left Ventricular Dysfunction (SOLVD) will be analyzed using the proposed method...
  46. PROGNOSTIC SIGNIFICANCE OF T WAVE ALTERNANS
    J Bigger; Fiscal Year: 2003
    ..that implantation of an ICD will reduce mortality in patients with congestive heart failure (CHF) and left ventricular dysfunction without any further risk stratification...
  47. Myocardial Gene Transfer during Cardiac Surgery in Swine
    Carmelo Milano; Fiscal Year: 2006
    ..States of left ventricular dysfunction or heart failure (HF) can be ameliorated with exogenous genes which alter the native #-adrenergic ..
  48. IMMUNOMODULATION OF RETROVIRAL CARDIOPATHOLOGY
    RONALD WATSON; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract) Pericardial effusion, cardiomyopathy, and left ventricular dysfunction are prevalent in patients with AIDS...
  49. Genes Differentially Expressed During Heart Failure
    JUDITH GWATHMEY; Fiscal Year: 2005
    ..more patients are surviving their first myocardial infarction, they go on to develop progressive left ventricular dysfunction and end-stage heart failure. As a result, the incidence of congestive heart failure is increasing...
  50. HEART RATE VARIABILILTY AND SUDDEN CARDIAC DEATH
    J Bigger; Fiscal Year: 1992
    ..after myocardial infarction, predicts mortality in the subsequent two to four years independently of left ventricular dysfunction and spontaneous ventricular arrhythmias...
  51. Software Promotes NCEP/AHA Provider Guideline Adherence
    Lawrence Baruch; Fiscal Year: 2003
    ..infarction, and the usage of t3-blockers and converting enzyme inhibitors in patients with systolic left ventricular dysfunction. The failure of implementation of optimal evidenced based guideline care has been attributed to a ..
  52. ALCOHOL INDUCED IMMUNOMODULATION--RETROVIRAL CARDIOPATH
    RONALD WATSON; Fiscal Year: 2003
    Cardiomyopathy and left ventricular dysfunction are prevalent in people with AIDS or chronic alcohol use. However almost nothing is known of the combined effects of retroviral infection plus alcohol on heart disease...
  53. Cellular Cardiomyoplasty for Acute and Chronic Ischemic
    Eduardo Marban; Fiscal Year: 2009
    ..cellular cardiomyoplasty for the treatment of ischemic heart disease, both post-myocardial infarction left ventricular dysfunction as well as chronic ischemic cardiomyopathy...
  54. Implanted Cardiac Defibrillators for Heart Failure Patients with Kidney Disease
    David Kent; Fiscal Year: 2009
    ..First, we will use primary data from a HF population without an ICD enrolled in the Study of Left Ventricular Dysfunction (SOLVD) trials to estimate how variation in severity of HF and CKD affect the risk of cause-specific ..
  55. ALTERNATIVES TO ECMO FOR PEDIATRIC CIRCULATORY SUPPORT
    George Pantalos; Fiscal Year: 2002
    ..Experiments using an acutely prepared, infant animal model of left ventricular dysfunction will compare the efficacy of ECMO to CF and PF assist devices and the IABP by determining the ability ..
  56. STUDIES OF LEFT VENTRICULAR DYSFUNCTION
    Robert Kohn; Fiscal Year: 1991
    ..which is one of an estimated twenty five centers that will conduct a large scale clinical trial on left ventricular dysfunction. The primary objective of the trial is to answer two questions: (1) In patients with moderate left ..
  57. CHRONIC ISCHEMIC LEFT VENTRICULAR DYSFUNCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The drug we will test is carvedilol because of its unique adrenergic inhibitor properties as well as its anti-oxidant and anti-apoptotic properties. ..
  58. ANGIOTENSIN II AND MITOGEN ACTIVATED PROTEIN KINASE
    Willa Hsueh; Fiscal Year: 2003
    Applicant's Abstract Cardiac fibrosis progression to left ventricular dysfunction and ultimately heart failure are a common in diabetes...