ventricular dysfunction

Summary

Summary: A condition in which the ventricles of the heart exhibit a decreased functionality.

Top Publications

  1. ncbi Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    Margaret M Redfield
    Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 9, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    JAMA 289:194-202. 2003
  2. ncbi Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy
    D Cesselli
    Department of Medicine, New York Medical College, Valhalla, NY, USA
    Circ Res 89:279-86. 2001
  3. pmc Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction
    Limei Zhou
    Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL 32816 2364, USA
    Circ Res 98:1177-85. 2006
  4. ncbi Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice
    Alessandra Medeiros
    School of Physical Education and Sport, University of Sao Paulo, Brazil
    J Appl Physiol (1985) 104:103-9. 2008
  5. pmc Racial differences in incident heart failure among young adults
    Kirsten Bibbins-Domingo
    Department of Medicine and the Division of General Internal Medicine and the UCSF Center for Vulnerable Populations, San Francisco General Hospital, University of California, San Francisco, San Francisco, USA
    N Engl J Med 360:1179-90. 2009
  6. ncbi Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
    Maria Paz Ocaranza
    Departamento Enfermedades Cardiovasculares, Escuela de Medicina, P Universidad Catolica de Chile
    Hypertension 48:572-8. 2006
  7. ncbi [Echocardiographic criteria for the definition of ventricular dysfunction severity in aortic banded rats]
    Vanessa Oliveira Moreira
    Faculdade de Medicina de Botucatu, UNESP, Botucatu, SP
    Arq Bras Cardiol 86:432-8. 2006
  8. ncbi Dysautonomia and ventricular dysfunction in the indeterminate form of Chagas disease
    Roberta B G Molina
    Departamento de Clinica Medica, Faculdade de Medicina de Botucatu Universidade Estadual Paulista, UNESP, Brazil
    Int J Cardiol 113:188-93. 2006
  9. pmc Clinical review: Myocardial depression in sepsis and septic shock
    Olivier Court
    Section of Critical Care Medicine, Health Sciences Center, University of Manitoba, Winnipeg, Canada
    Crit Care 6:500-8. 2002
  10. ncbi N-terminal probrain natriuretic peptide (NT-proBNP) in the emergency diagnosis and in-hospital monitoring of patients with dyspnoea and ventricular dysfunction
    Antoni Bayes-Genis
    Emergency Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Eur J Heart Fail 6:301-8. 2004

Detail Information

Publications242 found, 100 shown here

  1. ncbi Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    Margaret M Redfield
    Division of Cardiovascular Diseases, Department of Internal Medicine, Guggenheim 9, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    JAMA 289:194-202. 2003
    ..Yet, the prevalence of diastolic dysfunction and its relation to systolic dysfunction and CHF in the community remain undefined...
  2. ncbi Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy
    D Cesselli
    Department of Medicine, New York Medical College, Valhalla, NY, USA
    Circ Res 89:279-86. 2001
    ..In conclusion, cardiac cell death precedes ventricular decompensation and correlates with the time-dependent deterioration of function in this model. Oxidative stress may be critical for activation of apoptosis in the overloaded heart...
  3. pmc Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction
    Limei Zhou
    Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL 32816 2364, USA
    Circ Res 98:1177-85. 2006
    ..MCPIP expression increased in parallel with the development of ventricular dysfunction. In situ hybridization showed the presence of MCPIP transcripts in the cardiomyocytes and ..
  4. ncbi Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice
    Alessandra Medeiros
    School of Physical Education and Sport, University of Sao Paulo, Brazil
    J Appl Physiol (1985) 104:103-9. 2008
    ..We tested the hypothesis that ET would prevent Ca(2+) handling abnormalities and ventricular dysfunction in sympathetic hyperactivity-induced HF mice...
  5. pmc Racial differences in incident heart failure among young adults
    Kirsten Bibbins-Domingo
    Department of Medicine and the Division of General Internal Medicine and the UCSF Center for Vulnerable Populations, San Francisco General Hospital, University of California, San Francisco, San Francisco, USA
    N Engl J Med 360:1179-90. 2009
    ..The antecedents and epidemiology of heart failure in young adults are poorly understood...
  6. ncbi Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
    Maria Paz Ocaranza
    Departamento Enfermedades Cardiovasculares, Escuela de Medicina, P Universidad Catolica de Chile
    Hypertension 48:572-8. 2006
    ..Thus, the decrease in ACE2 expression and activity and circulating Ang-(1-9) levels in late ventricular dysfunction post-myocardial infarction were prevented with enalapril...
  7. ncbi [Echocardiographic criteria for the definition of ventricular dysfunction severity in aortic banded rats]
    Vanessa Oliveira Moreira
    Faculdade de Medicina de Botucatu, UNESP, Botucatu, SP
    Arq Bras Cardiol 86:432-8. 2006
    ..The purpose of this study was to identify echocardiographic parameters that allow distinguishing different levels of cardiac dysfunction in aortic banded rats...
  8. ncbi Dysautonomia and ventricular dysfunction in the indeterminate form of Chagas disease
    Roberta B G Molina
    Departamento de Clinica Medica, Faculdade de Medicina de Botucatu Universidade Estadual Paulista, UNESP, Brazil
    Int J Cardiol 113:188-93. 2006
    ..The associations between autonomic function and biventricular function in patients with the indeterminate form of Chagas disease remains to be elucidated...
  9. pmc Clinical review: Myocardial depression in sepsis and septic shock
    Olivier Court
    Section of Critical Care Medicine, Health Sciences Center, University of Manitoba, Winnipeg, Canada
    Crit Care 6:500-8. 2002
    ..The present paper reviews both the clinical manifestations and the molecular/cellular mechanisms of sepsis-induced myocardial depression...
  10. ncbi N-terminal probrain natriuretic peptide (NT-proBNP) in the emergency diagnosis and in-hospital monitoring of patients with dyspnoea and ventricular dysfunction
    Antoni Bayes-Genis
    Emergency Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Eur J Heart Fail 6:301-8. 2004
    To evaluate the utility of NT-proBNP in the emergency diagnosis and in-hospital monitoring of patients with acute dyspnoea and ventricular dysfunction.
  11. pmc Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction
    Tetsuro Shishido
    Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Circ Res 102:1416-25. 2008
    ..These results demonstrated that ERK5 transcriptional activity is subject to downregulation by diabetes-dependent SUMOylation, which resulted in a proapoptotic condition contributing to poor post-MI LV function...
  12. ncbi Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure
    Renata M Lataro
    Departments of Physiology and
    Am J Physiol Regul Integr Comp Physiol 305:R908-16. 2013
    ..administration of pyridostigmine started right after coronary artery ligation augmented cardiac vagal and reduced sympathetic tone, attenuating cardiac remodeling and left ventricular dysfunction during the progression of HF in rats.
  13. ncbi Blockade of NF-kappaB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in rats
    Shumei Li
    Department of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University, Fuzhou, China
    Basic Res Cardiol 105:139-50. 2010
    ..Patients with or at risk of CME may benefit from acute anti-inflammatory treatment with PDTC...
  14. ncbi Ventricular dysfunction associated with brain trauma is cause for exclusion of young heart donors
    M Godino
    Instituto Nacional de Donación y Transplante, Hospital de Clinicas, Montevideo, Uruguay
    Transplant Proc 42:1507-9. 2010
    b>Ventricular dysfunction (VD) in the context of brain death (BD) is one medical cause that may be reversed to extend the range of donors for cardiac transplant programs...
  15. ncbi Ventricular dysfunction and dilation in severe sepsis and septic shock: relation to endothelial function and mortality
    Thiago Furian
    Cardiology and Cardiovascular Sciences, Medical School from Rio Grande doSul Federal University, Brasil
    J Crit Care 27:319.e9-15. 2012
    ..The aim of this study was to evaluate echocardiography-based indices of myocardial function and markers of vascular inflammation and endothelial dysfunction in the early phases of severe sepsis...
  16. ncbi Long-term administration of tempol attenuates postinfarct ventricular dysfunction and sympathetic activity in rats
    Zhen Shi
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Pflugers Arch 458:247-57. 2009
    ..of this study was to determine whether the long-term administration of tempol attenuates postinfarct ventricular dysfunction and sympathetic activity in rats...
  17. ncbi Heart failure and ventricular dysfunction in patients with single or systemic right ventricles
    Sanaz Piran
    Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network, University of Toronto, University of Toronto, Canada
    Circulation 105:1189-94. 2002
    ..Previous studies suggested a high incidence of congestive heart failure in patients with single and/or systemic right ventricles. The corresponding risk in an adult population is unknown...
  18. ncbi Corticosteroid treatment retards development of ventricular dysfunction in Duchenne muscular dystrophy
    Larry W Markham
    Monroe Carell, Jr Children s Hospital Vanderbilt University, Division of Pediatric Cardiology, 2200 Children s Way, Suite 5230, Nashville, TN 37232, USA
    Neuromuscul Disord 18:365-70. 2008
    ..The primary objective of this work is to determine benefit from steroid treatment on the development of ventricular dysfunction in DMD...
  19. ncbi Epidemiology of heart failure and left ventricular dysfunction after acute myocardial infarction
    Robin A P Weir
    Department of Cardiology, Western Infirmary, Glasgow, G11 6NT, United Kingdom
    Curr Heart Fail Rep 3:175-80. 2006
    ..Advances in the management of acute myocardial infarction have led to reduced in-hospital mortality (even when complicated by heart failure), but longer-term mortality remains high in these patients...
  20. ncbi The failing Fontan: options for surgical therapy
    C B Huddleston
    Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO, USA
    Pediatr Cardiol 28:472-6. 2007
    ..Every effort should be made to identify which hemodynamic factors are responsible for late failures. However, cardiac transplantation will likely be necessary for the majority of patients...
  21. ncbi Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death?
    Marius Berman
    Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 29:957-65. 2010
    ..and the heart of a brain-dead donor: exposure of the heart to unusually high catecholamine levels, ventricular dysfunction, and prompt recovery...
  22. pmc IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart
    Indroneal Banerjee
    Department of Cell and Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA
    Am J Physiol Heart Circ Physiol 296:H1694-704. 2009
    ..Taken together, these data demonstrate that a loss of IL-6 causes cardiac dysfunction by shifting the cardiac cell populations, altering the extracellular matrix, and disrupting critical cell-cell interactions...
  23. ncbi Effect of high salt intake on local renin-angiotensin system and ventricular dysfunction following myocardial infarction in rats
    Micheline M de Resende
    Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, Espirito Santo, Brazil
    Clin Exp Pharmacol Physiol 34:274-9. 2007
    ..PRA, but did not prevent activation of the local RAS or the progression of cardiac remodelling and left ventricular dysfunction caused by MI. 6...
  24. ncbi Magnetic resonance imaging assessment of ventricular dyssynchrony: current and emerging concepts
    Albert C Lardo
    Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Coll Cardiol 46:2223-8. 2005
    ....
  25. ncbi Asymmetric dimethylarginine (ADMA) induces vascular endothelium impairment and aggravates post-ischemic ventricular dysfunction in rats
    Vito De Gennaro Colonna
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, Italy
    Eur J Pharmacol 557:178-85. 2007
    ..whether ADMA (10 mg/kg day for 14 days) affected endothelial function and aggravated post-ischemic ventricular dysfunction in the perfused rat heart...
  26. ncbi Association of hyperadiponectinemia with severity of ventricular dysfunction in congestive heart failure
    Tomohiro Nakamura
    Department of Medicine, Jichi Medical University Omiya Medical Center, Saitama Japan
    Circ J 70:1557-62. 2006
    ..Plasma adiponectin levels in patients with congestive heart failure (CHF) were determined, as well as relationships between the plasma levels of adiponectin and other hormones...
  27. ncbi Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony
    James A White
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 48:1953-60. 2006
    ..We evaluated the ability of delayed enhancement magnetic resonance imaging (DE-MRI) to predict clinical response to cardiac resynchronization therapy (CRT)...
  28. ncbi Ventricular dysfunction in early diabetic heart disease: detection, mechanisms and significance
    Gerald F Watts
    School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital Unit, GPO Box X22 13, Perth WA 6847, Australia
    Clin Sci (Lond) 105:537-40. 2003
    ..The aetiology of early ventricular dysfunction in diabetes relates to complex intramyocardial and extramyocardial mechanisms...
  29. ncbi Early experience with Levosimendan in children with ventricular dysfunction
    Poongundran Namachivayam
    Intensive Care Unit, The Royal Children s Hospital, Melbourne, Australia
    Pediatr Crit Care Med 7:445-8. 2006
    ..To describe our preliminary experience with Levosimendan, a new calcium-sensitizing agent in critically unwell infants and children with severe heart failure...
  30. ncbi Adverse effects of ACE inhibitors in patients with chronic heart failure and/or ventricular dysfunction : meta-analysis of randomised clinical trials
    Antonia Agustí
    Fundació Institut Català de Farmacologia Servei de Farmacologia Clínica, Hospital Universitari Vall d Hebron, and Department of Pharmacology, Therapeutics and Toxicology, Universitat Autonoma de Barcelona, Barcelona, Spain
    Drug Saf 26:895-908. 2003
    ..ample evidence that ACE inhibitors improve the symptoms and prognosis of chronic heart failure (CHF) and ventricular dysfunction. However, there is little systematic information on the tolerability and adverse effects associated with ..
  31. ncbi Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong
    Circulation 105:438-45. 2002
    ..This study investigated the effect of biventricular pacing on reverse remodeling and the underlying mechanisms...
  32. ncbi Critical appraisal of methods to assess mechanical dyssynchrony
    Cheuk Man Yu
    Institute of Vascular Medicine, Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University ofHong Kong, Shatin, NT Hong Kong
    Curr Opin Cardiol 24:18-28. 2009
    ..Also, controversies and problematic issues of the recent predictors of response to cardiac resynchronization therapy study were addressed...
  33. ncbi Transcriptional networks characterize ventricular dysfunction after myocardial infarction: a proof-of-concept investigation
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public, santé, Luxembourg
    J Biomed Inform 43:812-9. 2010
    There is currently no method powerful enough to identify patients at risk of developing ventricular dysfunction after myocardial infarction (MI)...
  34. ncbi Gender related differences in patients presenting with acute heart failure. Results from EuroHeart Failure Survey II
    Markku S Nieminen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland
    Eur J Heart Fail 10:140-8. 2008
    ..This analysis evaluates the gender differences in patients hospitalised for acute heart failure (AHF) in the EuroHeart Failure Survey II (EHFS)...
  35. ncbi Percutaneous treatment of neonatal aortic coarctation presenting with severe left ventricular dysfunction as a bridge to surgery
    Ivan Bouzguenda
    centre de référence des malformations congénitales complexes M3C, Universite Paris V, Necker Enfants Malades, 149 rue de Sevres, Paris, France
    Cardiol Young 19:244-51. 2009
    ..Neonatal aortic coarctation presenting with multiorgan failure is a life threatening condition...
  36. pmc Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting
    Amanda A Fox
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 110:738-47. 2009
    b>Ventricular dysfunction (VnD) after primary coronary artery bypass grafting is associated with increased hospital stay and mortality...
  37. ncbi Influence of valve prosthesis type on the recovery of ventricular dysfunction and subendocardial ischaemia following valve replacement for aortic stenosis
    Julian Collinson
    Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust and National Heart and Lung Institute, London, UK
    Int J Cardiol 97:535-41. 2004
    ..Following aortic valve surgery, LV function may improve and this may be accompanied by reversal of ischaemia. There is debate about the differential effects of valve substitutes...
  38. ncbi Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation
    Richard C Saumarez
    Department of Cardiology, Papworth Hospital, University of Cambridge, Cambridge CB3 8RE, UK
    Circulation 107:2595-600. 2003
    ....
  39. ncbi Usefulness of plasma B-type natriuretic peptide to identify ventricular dysfunction in pediatric and adult patients with congenital heart disease
    Yuk M Law
    Division of Pediatric Cardiology, Doernbecher Children s Hospital, Oregon Health and Science University, Portland, Oregon, USA
    Am J Cardiol 95:474-8. 2005
    The usefulness of B-type natriuretic peptide (BNP) levels to assess ventricular dysfunction in children and the congenital heart disease population remains largely unknown...
  40. pmc Preoperative B-type natriuretic peptide is as independent predictor of ventricular dysfunction and mortality after primary coronary artery bypass grafting
    Amanda A Fox
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 136:452-61. 2008
    ..We hypothesized that preoperative plasma B-type natriuretic peptide would independently predict in-hospital postoperative ventricular dysfunction, hospital stay, and up to 5-year mortality after primary coronary artery bypass grafting.
  41. ncbi Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure
    Tamara B Horwich
    Ahmanson UCLA Cardiomyopathy Center, UCLA Division of Cardiology, 47 123 CHS, 10833 Le Conte Ave, Los Angeles, Calif 90095 1679, USA
    Circulation 108:833-8. 2003
    ..Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes...
  42. ncbi Xanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction?
    Roger J Hajjar
    Circ Res 98:169-71. 2006
  43. ncbi Initial experience with nifekalant hydrochloride (MS-551), a novel class III antiarrhythmic agent, in patients with acute extensive infarction and severe ventricular dysfunction
    K Takenaka
    Division of Cardiology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Jpn Circ J 65:60-2. 2001
    ..agent, was used as the treatment in 4 patients with extensive anterior infarction and severe ventricular dysfunction. The malignant ventricular tachyarrhythmia was effectively suppressed at a relatively low dose, without ..
  44. pmc Biochemical diagnosis of ventricular dysfunction in elderly patients in general practice: observational study
    H Smith
    Primary Medical Care, University of Southampton, Aldermoor Health Centre, Southampton SO16 5ST
    BMJ 320:906-8. 2000
    ..To investigate the usefulness of measuring plasma concentrations of B type natriuretic peptide in the diagnosis of left ventricular systolic dysfunction in an unselected group of elderly people...
  45. ncbi Mitral regurgitation in patients with advanced systolic heart failure
    Jeetendra B Patel
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Card Fail 10:285-91. 2004
    ..Our objective was to define the prevalence, clinical correlates, and prognostic implications of functional MR and the use of mitral annuloplasty in patients with advanced systolic CHF evaluated in a heart failure clinic...
  46. ncbi Ejection fraction and QRS width as predictors of event rates in patients with implantable cardioverter defibrillators
    Mahi Lakshmi Ashwath
    Mercer University School of Medicine, Macon, GA, USA
    South Med J 98:513-7. 2005
    ..These ICDs were placed over the past 5 years for various indications...
  47. ncbi Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly
    Daisy Pavoni
    Division of Cardiology, S Maria degli Angeli Hospital, Pordenone, Italy
    Ital Heart J 4:891-4. 2003
    ..In our case this interatrial shunt was very accurately detected at bubble contrast echocardiography...
  48. ncbi [Arrhythmia in the long-term follow-up after intracardiac repair of tetralogy of Fallot]
    Ying Guo
    Department of Pediatrics, Xinhua Hospital, Shanghai Second Medical College, Shanghai Children s Medical Center, Shanghai 200127, China
    Zhonghua Er Ke Za Zhi 41:728-31. 2003
    ..The aim of the present study was to determine the incidence of arrhythmias after intracardiac repair of tetralogy of Fallot and their correlation with surgical and clinical findings...
  49. ncbi Prevalence of diastolic dysfunction as a possible cause of dyspnea in the elderly
    Frants Pedersen
    Frederiksberg University Hospital, Department of Cardiology and Endocrinology, Nordre Fasanvej 57, DK 2000 Frederiksberg Copenhagen, Denmark
    Am J Med 118:25-31. 2005
    ....
  50. ncbi Elevated brain natriuretic peptide and reduced exercise capacity in adult patients operated on for tetralogy of fallot is due to biventricular dysfunction as determined by the myocardial performance index
    Kambiz Norozi
    Department of Paediatric Cardiology and Intensive Care Medicine, Medical School Hannover, Hannover, Germany
    Am J Cardiol 97:1377-82. 2006
    ..The combined determinations of these 3 variables enable the identification of congenital heart disease with impaired cardiac function before they become clinically symptomatic...
  51. ncbi Increased intra-QRS fragmentation in magnetocardiography as a predictor of arrhythmic events and mortality in patients with cardiac dysfunction after myocardial infarction
    Petri Korhonen
    Division of Cardiology, Helsinki University Central Hospital, PL 340, 00029 HUS, Finland
    J Cardiovasc Electrophysiol 17:396-401. 2006
    ..The aim of this study was to investigate whether increased FRA in MCG predicts arrhythmic events and mortality after acute myocardial infarction (MI) with cardiac dysfunction...
  52. ncbi Effects of cardiac resynchronization therapy on ventricular repolarization in patients with congestive heart failure
    Thomas Berger
    Innsbruck Medical University, Clinical Division of Cardiology, A 6020 Innsbruck, Austria
    J Cardiovasc Electrophysiol 16:611-7. 2005
    ..The aim of our study was to evaluate the effect of biventricular pacing on ECG markers of ventricular repolarization in patients with congestive heart failure...
  53. ncbi Intrafamilial variability of noncompaction of the ventricular myocardium
    Mark T Johnson
    Department of Genetics, Case University, Cleveland, OH, USA
    Am Heart J 151:1012.e7-14. 2006
    ..Noncompaction of the ventricular myocardium (NVM) is a relatively uncommon form of cardiomyopathy characterized by a highly trabeculated myocardium. This report describes the clinical and genetic evaluation of a 3-generation kindred...
  54. ncbi Heart failure patients with ventricular dysynchrony: management with a cardiac resynchronization therapy device
    Jean Flanagan
    Washington University Medical Center, St Louis, MO, USA
    Prog Cardiovasc Nurs 18:184-9. 2003
    ..The focus on patient education throughout this article may allow it to serve as a reference for health care providers involved in the care of patients with severe heart failure...
  55. ncbi Cardiac resynchronisation therapy for patients with heart failure
    Robert Frodsham
    Coronary Care Unit, Whiston Hospital, Prescot, Liverpool
    Nurs Stand 19:46-50. 2005
    ..This article discusses symptoms, morbidity and mortality of heart failure; potential benefits of CRT to patients' quality of life; and the implications of CRT for nursing practice...
  56. ncbi Both systolic and diastolic dysfunction characterize nonischemic inhibition of myocardial energy metabolism: an experimental strain rate echocardiographic study
    Josef Korinek
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Echocardiogr 17:1239-44. 2004
    ..However, regional functional changes can be affected by structural alterations. We developed an experimental model of sole myocardial energy metabolism inhibition and characterized the resulting regional dysfunction...
  57. ncbi Chagas myocarditis and syncope
    Rajan A G Patel
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    J Cardiovasc Magn Reson 7:685-8. 2005
    ..The discussion summarizes the pathophysiology of cardiac Chagas disease. Acute, latent, and chronic Chagas myocarditis are described. The role of CMR in diagnosing Chagas myocarditis is discussed...
  58. ncbi Segmental wall motion abnormalities in idiopathic dilated cardiomyopathy and their effect on prognosis
    Laurent Fauchier
    Services de Service de Cardiologie B, Centre Hospitalier Universitaire Trousseau, Tours, France
    Am J Cardiol 93:1504-9. 2004
    ..Thus, segmental wall motion abnormalities are frequent in IDC and are associated with severe systolic dysfunction and a worse prognosis...
  59. ncbi Impact of conventional versus biventricular pacing on hemodynamics and tissue Doppler imaging indexes of resynchronization postoperatively in children with congenital heart disease
    Phat P Pham
    Oregon Health and Science University, Portland, Oregon, USA
    J Am Coll Cardiol 46:2284-9. 2005
    ....
  60. ncbi Dispersion of repolarization in cardiac resynchronization therapy
    Bart Hooft Van Huysduynen
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Heart Rhythm 2:1286-93. 2005
    ..The possibility of identifying these patients by ECG repolarization indices has been suggested...
  61. ncbi Cardiomyopathy in Becker muscular dystrophy--does regional fibrosis mimic infarction?
    Colin J Petrie
    Department of Cardiology, Western Infirmary, Glasgow, UK
    J Cardiovasc Magn Reson 7:823-5. 2005
    ....
  62. ncbi Comparison of left ventricular-biventricular pacing on ventricular synchrony, mitral regurgitation, and global left ventricular function in patients with severe chronic heart failure
    Dragos Vinereanu
    Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Am J Cardiol 94:519-21. 2004
    ..Intraventricular synchrony, regional and global systolic function, diastolic function and filling time, and the severity of secondary mitral regurgitation were similar between left ventricular and biventricular pacing...
  63. ncbi [Value and limitations of programmed ventricular stimulation]
    A Leenhardt
    Service de cardiologie, Hopital Lariboisiere, 2, rue Ambroise Pare, 75475 Paris
    Arch Mal Coeur Vaiss 98:6-14. 2005
    ....
  64. pmc Systolic and diastolic function in middle aged patients with sickle beta thalassaemia. An echocardiographic study
    I Moyssakis
    Cardiology Department, Laiko General Hospital, Athens, Greece
    Postgrad Med J 81:711-4. 2005
    ..To evaluate the right and left ventricular systolic and diastolic function in middle aged patients with sickle beta thalassaemia...
  65. ncbi Heart failure: what proportion of patients satisfy the electrocardiographic criteria for cardiac resynchronization therapy?
    Satya N Gupta
    Department of Cardiology, Christian Medical College and Hospital, Vellore
    Indian Heart J 55:619-23. 2003
    ..The purpose of this study was to find out what proportion of Indian patients with congestive heart failure may be candidates for cardiac resynchronization therapy based on electrocardiographic characteristics...
  66. ncbi Who is the best candidate for cardiac resynchronization therapy: implications of recent studies
    Arash Arya
    Department of Pacemaker and Electrophysiology, Rajaie Cardiovascular Medical Center, Mellat Park, Vali Asr Avenue, Tehran, Iran
    Indian Heart J 55:611-4. 2003
  67. ncbi Preoperative moderate to severe diastolic dysfunction: a novel Doppler echocardiographic long-term prognostic factor in patients with severe aortic stenosis
    Peter Gjertsson
    Department of Clinical Physiology, Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    J Thorac Cardiovasc Surg 129:890-6. 2005
    ..We studied long-term outcomes in severe aortic stenosis and the importance of prosthesis type (mechanical vs biologic) and size, preoperative left ventricular ejection fraction, diastolic function, and left ventricular mass...
  68. ncbi Cardiac resynchronization: a brief synopsis part I: patient selection and results from clinical trials
    David M Kalinchak
    Medtronic, Inc, 7000 Central Avenue NE, Minneapolis, MN 55432, USA
    J Interv Card Electrophysiol 9:155-61. 2003
    ....
  69. ncbi [Diastolic dysfunction--predictor of cardiac remodeling in arterial hypertension in young males]
    E E Mineeva
    Klin Med (Mosk) 86:23-5. 2008
    ..Diastolic dysfunction of left and right ventricle appears at the prehypertension stage and stage 1 arterial hypertension and precedes heart remodeling...
  70. ncbi Long-term effects of atrial synchronous ventricular pacing on systolic and diastolic ventricular function in patients with normal left ventricular ejection fraction
    John A Chiladakis
    Department of Cardiology, Patras University Hospital, Patras, Greece
    Cardiology 108:290-6. 2007
    ....
  71. ncbi Cardiac resynchronization therapy improves heart rate variability in patients with symptomatic heart failure
    Philip B Adamson
    Department of Internal Medicine, Cardiovascular Disease Section, University of Oklahoma Health Sciences Center, PO Box 26901, 920 SL Young Boulevard, WP3120, Oklahoma City, Okla 73104, USA
    Circulation 108:266-9. 2003
    ..The present study examined whether an improvement in ventricular performance from resynchronization therapy changes the autonomic control of heart rate...
  72. ncbi Myocardial dyssynchrony and resynchronization
    Theodore P Abraham
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Heart Fail Clin 2:179-92. 2006
  73. ncbi Chronic and acute effects of smoking on left and right ventricular relaxation in young healthy smokers
    Barbara Lichodziejewska
    Department of Internal Medicine and Cardiology, Institute of Dentistry, Warsaw Medical University, 02 005 Warsaw, Lindleya 4, Poland
    Chest 131:1142-8. 2007
    ..The aim of the study was to assess LV and right ventricular (RV) diastolic function in healthy, young, and slim smokers before and after smoking one cigarette...
  74. ncbi Quantification of regional right and left ventricular function by ultrasonic strain rate and strain indexes after surgical repair of tetralogy of Fallot
    Frank Weidemann
    Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Cardiol 90:133-8. 2002
    ..RV deformation abnormalities are associated with electrical depolarization abnormalities...
  75. ncbi Transient biventricular apical ballooning: a unique presentation of the "broken heart"
    Gregg Novak
    General Internal Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822 2160, USA
    Clin Cardiol 30:355-8. 2007
    ..Presence of RV dysfunction may affect the initial management of these patients and raises questions regarding the universal applicability of the currently proposed pathophysiologic mechanisms of this syndrome...
  76. ncbi Cardiac resynchronization therapy: left or left-and-right for optimal symptomatic effect--the LOLA ROSE study
    Alexander Sirker
    Sussex Cardiac Centre, Royal Sussex County Hospital, Eastern Road, Brighton BN2 5BE, East Sussex, UK
    Europace 9:862-8. 2007
    ..The impact of modern refinements in pacing optimization on the relative benefits of these two modes is unknown. We aimed to compare these two modes in patients with heart failure, using Echo-based optimization of each pacing mode...
  77. ncbi Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development
    D Vaidya
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Circ Res 88:1196-202. 2001
    ..This study demonstrates the contribution of Cx43 to the electrical function of the developing mouse heart and the essential role of this gene in maintaining heart rhythm in postnatal life...
  78. ncbi Circulatory support for long-term treatment of heart failure: experience with an intraventricular continuous flow pump
    Stephen Westaby
    Oxford Heart Centre, Oxford, UK
    Circulation 105:2588-91. 2002
    ..After extensive laboratory testing, we began clinical trials with an axial flow pump for long-term treatment of New York Heart Association class IV, transplant-ineligible patients...
  79. doi Letter by Hamilton and Filardo regarding article, "Reduced ventricular volumes and improved systolic function with cardiac resynchronization therapy: a randomized trial comparing simultaneous biventricular pacing, sequential biventricular pacing, and
    Cody Hamilton
    Circulation 117:e14; author reply e15. 2008
  80. ncbi Systolic heart failure: chronic and acute syndromes
    Kanu Chatterjee
    Chatterjee Center for Cardiac Research, University of California, San Francisco, USA
    Crit Care Med 36:S44-51. 2008
    ..This review discusses remodeling, initial therapy based on neurohormonal modulation, and treatment of decompensated and refractory heart failure. Diagnosis, prognosis, and management of acute myocarditis are also discussed...
  81. ncbi Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism
    Kenneth E Wood
    Department of Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
    Chest 121:877-905. 2002
    ..Thrombolytic therapy is acknowledged as the treatment of choice, with embolectomy reserved for those in whom thrombolysis is contraindicated...
  82. ncbi [Selection of patients for resynchronization therapy. "The role of echocardiography"]
    Ramón José Cué-Carpio
    Departamento de Urgencias y Unidad Coronaria, Instituto Nacional de Cardiologia Ignacio Chavez, Tlalpan, Mexico, DF
    Arch Cardiol Mex 77:S2-14-S2-23. 2007
    ..The aim of this article was to review the different techniques echocardiography's to guide in the selection patients who benefice of resynchronization therapy...
  83. ncbi Determinants of tissue Doppler measures of regional diastolic function during dobutamine stress echocardiography
    Ofelia Najos-Valencia
    University of Queensland, Brisbane, Australia
    Am Heart J 144:516-23. 2002
    ..We sought to examine the stress response of regional diastolic parameters to dobutamine echocardiography (DbE)...
  84. ncbi Diastolic dysfunction: pathophysiology, clinical features, and assessment with radionuclide methods
    A Aggarwal
    Cardiology Unit, University of Vermont, Burlington, VT 05401, USA
    J Nucl Cardiol 8:98-106. 2001
    Basic to our understanding of heart failure is the distinction between systolic and diastolic ventricular dysfunction. Diastolic dysfunction implies that the ventricle cannot accept blood at normally low pressures...
  85. ncbi Transient midventricular ballooning syndrome: a new variant
    R Todd Hurst
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona 85260, USA
    J Am Coll Cardiol 48:579-83. 2006
    ..of the transient ventricular ballooning syndromes and other cases of catecholamine-associated transient ventricular dysfunction are not well understood, the emergence of this new variant raises further questions in the understanding ..
  86. ncbi Comparative analysis of systolic and isolated diastolic dysfunction: Sado heart failure study
    Mahmoud M Ramadan
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int Heart J 49:459-69. 2008
    ..769-4.808]) was independently associated with SD. In conclusion, some factors/comorbidities were more likely to associate with IDD (female gender, stroke, and malignancy) or SD (previous MI) when IDD and SD were compared with each other...
  87. ncbi Camphor induced myocarditis: a case report
    Maneesha Bhaya
    Department of Cardiology, Sardar Patel Medical College, 6 Chanyakya Nagar New Shivbari Road, Bikaner 334003, India
    Cardiovasc Toxicol 7:212-4. 2007
    ..The medicinal uses of camphor are unsupported by evidence and safer, more effective alternatives exist. Its use in household products and edibles should be discouraged...
  88. ncbi Right ventricular pacing can induce ventricular dyssynchrony in patients with atrial fibrillation after atrioventricular node ablation
    Laurens F Tops
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 48:1642-8. 2006
    ..This study was designed to assess the effects of long-term right ventricular (RV) pacing on left ventricular (LV) dyssynchrony, LV function, and heart failure symptoms...
  89. ncbi Skin-autofluorescence, a measure of tissue advanced glycation end-products (AGEs), is related to diastolic function in dialysis patients
    Jasper W L Hartog
    Department of Cardiology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    J Card Fail 14:596-602. 2008
    ..The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction...
  90. pmc Endomyocardial fibrosis: progression to restricted ventricles and giant atria
    Eloi Marijon
    Service de cardiologie, Hopital Europeen Georges Pompidou, Paris, France
    Can J Cardiol 22:1163-4. 2006
  91. ncbi Cardiac resynchronization in 2008: an echo approach
    John Gorcsan
    The Cardiovascular Institute, University of Pittsburgh, Scaife Hall 564, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Curr Cardiol Rep 10:211-7. 2008
    ..Echocardiographic assessment of dyssynchrony continues to evolve, with new information being added continually, and appears to have promise for future clinical applications...
  92. ncbi Reduction of tricuspid annular doppler tissue velocities in pediatric heart transplant patients
    Derek A Fyfe
    Sibley Heart Center, Children s Healthcare of Atlanta, Atlanta, Georgia 30329, USA
    J Heart Lung Transplant 22:553-9. 2003
    ....
  93. ncbi Transposition of the great arteries
    Carole A Warnes
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 114:2699-709. 2006
    ..All patients should be seen periodically in a center where expertise in the clinical evaluation, imaging, and hemodynamic assessment of adult congenital heart disease is available...
  94. ncbi Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations
    Miho Kawaguchi
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 107:714-20. 2003
    ..We hypothesized that such patients also display combined ventricular-systolic and arterial stiffening that can exacerbate blood pressure lability and diastolic dysfunction under stress...
  95. ncbi Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity
    Qunying Yuan
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    Circulation 115:300-9. 2007
    ..The essential physiological effects of junctin and its potential regulatory roles in sarcoplasmic reticulum Ca cycling and Ca-dependent cardiac functions, such as myocyte contractility and automaticity, are unknown...
  96. pmc Fontan conversion to total cavopulmonary connection and arrhythmia ablation: clinical and functional results
    G Agnoletti
    Divisione di Cardiologia, Ospedali Riuniti, Bergamo, Italy
    Heart 89:193-8. 2003
    ..To assess the early results of conversion from atriopulmonary to total cavopulmonary connection in patients with failing Fontan operation...
  97. ncbi Assessment of early changes in the segmental functions of the left and the right ventricles after biventricular pacing in heart failure: a study with tissue Doppler imaging
    Ahmet Kaya Bilge
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey
    Angiology 59:179-84. 2008
    ..Resynchronization therapy improved systolic and diastolic functions in both ventricles. The difference between transition time to contraction of ventricles might be helpful in estimating optimal resynchronization...
  98. ncbi Diastolic asynchrony is more frequent than systolic asynchrony in dilated cardiomyopathy and is less improved by cardiac resynchronization therapy
    Iris Schuster
    Echocardiography Laboratory, La Timone Hospital, Marseille, France
    J Am Coll Cardiol 46:2250-7. 2005
    ....
  99. pmc Cardiovascular profile of 5 novel nitrate-esters: a comparative study with nitroglycerin in pigs with and without left ventricular dysfunction
    L J van Woerkens
    Laboratory for Experimental Cardiology, Thoraxcentre, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Br J Pharmacol 104:7-14. 1991
    ..6. The potential of CEDO 8956 in the treatment of chronic left ventricular dysfunction was evaluated during administration to conscious pigs (21-23 kg), in which the left circumflex coronary ..
  100. ncbi A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of aldosterone antagonists for postmyocardial infarction heart failure
    C McKenna
    Centre for Health Economics, University of York, York, UK
    Health Technol Assess 14:1-162. 2010
    ..Recent clinical guidelines recommend eplerenone after an acute myocardial infarction (MI) for patients with symptoms and/or signs of HF and left ventricular dysfunction.
  101. ncbi Mild subclinical hypothyroidism in thalassaemia major: prevalence, multigated radionuclide test, clinical and laboratory long-term follow-up study
    Vincenzo De Sanctis
    Department of Reproduction, Paediatric and Thalassaemia Unit, St Anna Hospital, Ferrara, Italy
    Pediatr Endocrinol Rev 6:174-80. 2008
    ..3%). Global or segmental left ventricular dysfunction at rest and during exercise were found in 8 patients (66.6%) and 10 patients (83.3%), respectively...

Research Grants74

  1. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..is therefore a desperate need for innovative rather than incremental therapies to reverse the course of ventricular dysfunction. HF induced by genetic or specific conditions, such as coronary artery disease, hypertension, diabetes, ..
  2. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..Infusion/treatment of mice with salubrinal reduced the extent of 2-AR-stimulated and MI-induced left ventricular dysfunction and cardiac myocyte apoptosis in the heart...
  3. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..whose administration at the time of acute myocardial infarction might reduce post-ischemic left ventricular dysfunction and favorably improve long-term outcomes, such as heart failure and cardiac sudden death...
  4. Extracellular ubiquitin: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2010
    ..Infusion of mice with exogenous ubiquitin inhibited ?AR-stimulated left ventricular dysfunction, cardiac myocyte apoptosis and myocardial fibrosis in mice...
  5. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
  6. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
  7. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..In the second model, we will study the efficacy of SEW 2871 on ventricular dysfunction caused by ligation of the left anterior descending coronary artery in mice provided by Dr. Michael Mann...
  8. Cardioprotective Signaling following Phosphodiesterase-5 Inhibition
    Rakesh C Kukreja; Fiscal Year: 2012
    ..The most common long-term complication of AMI is the late occurrence of left ventricular dysfunction and heart failure...
  9. Aromatase Inhibitors in Pulmonary Vascular Complications of Liver Disease
    Steven M Kawut; Fiscal Year: 2013
    ..He heads a federally-funded research program based on the epidemiology and treatment of PVD and right ventricular dysfunction. He has also mentored more than twenty-nine trainees to success in patient-oriented research (POR), ..
  10. The Role of RAGE in Diabetes and Myocardial Infarction.
    KAREN O'SHEA; Fiscal Year: 2013
    ..We will assess differences in I/R-induced left ventricular dysfunction due to genetic strain by echocardiography...
  11. Genetic Analysis of Murine Chronic Hypoxia-Induced Pulmonary Hypertension
    William C Nichols; Fiscal Year: 2013
    ..It is widely recognized that right ventricular dysfunction plays a pivotal role in heart failure in patients with pulmonary arterial hypertension (PAH), ..
  12. In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRS
    Adil Bashir; Fiscal Year: 2013
    ..evidence that a mismatch in myocardial energy supply and demand contributes to the development of left ventricular dysfunction. Heart uses chemical energy in the form of adenosine triphosphate (ATP) to support systolic and diastolic ..
  13. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..After myocardial ischemia, TNF levels, ventricular dysfunction, and apoptosis are decreased in female myocardium...
  14. Regulation of Hypoxic Pulmonary Hypertension by MIF
    Todd M Kolb; Fiscal Year: 2012
    ..MIF in the RV response to PH, and may help to clarify the links between RV hypertrophy, metabolic change, ventricular dysfunction, and failure...
  15. Directing Stem Cell Differentiation on Biologically Inspired Micropatterned Surfa
    Anita Shukla; Fiscal Year: 2012
    ..have shown promise in the treatment of a variety of diseases, including osteogenesis imperfecta and left ventricular dysfunction. Better understanding of hMSC lineage commitment will allow the development of superior regenerative ..
  16. Metabolic Profiling of Acute Myocardial Injury in Humans
    GREGORY DYER LEWIS; Fiscal Year: 2012
    ..Specific Aim 4 will be to extend metabolic profiling beyond ischemia to identify metabolic modulators of ventricular dysfunction. The candidate will ultimately integrate training and results from this proposed award with his ..
  17. Fundamental Biology of SCD and its Application to Identify Patients at Risk
    GORDON FRANK TOMASELLI; Fiscal Year: 2013
    ..provided by applicant): More than 5 million people in the United States alone have advanced left ventricular dysfunction with an increased risk of dying suddenly and by current guidelines are candidates for implantable ..
  18. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..surgery patients who tend to have respiratory problems (like obstructive sleep apnea), right ventricular dysfunction, pulmonary hypertension, and for whom post-operative vomiting could result in serious complications...
  19. UFCC for Cardiovascular Cell Therapy Research Network
    Carl J Pepine; Fiscal Year: 2011
    ..The two UFCC protocols propose to develop cell therapy for CAD patients with left ventricular dysfunction/heart failure using direct intramural implantation by percutaneous catheter...
  20. Mechanisms of Right Ventricular Dysfunction in PAH
    DAVID ALAN KASS; Fiscal Year: 2013
    ....
  21. Right Ventricular-Pulmonary Vascular Interactions in Pulmonary Hypertension
    Naomi C Chesler; Fiscal Year: 2013
    ..We hypothesize that proximal arterial stiffening is responsible for right ventricular dysfunction via inefficient hemodynamic interactions...
  22. Amplification of Cardiosphere-Derived Cell Therapy
    BRIAN RAYMOND WEIL; Fiscal Year: 2013
    ..cells from older adults, ultimately leading to the development of novel strategies to optimize cardiac repair and prevent the progression of left ventricular dysfunction to clinical heart failure in patients wth coronary artery disease.
  23. Neurohormonal Blockade and Outcomes in Diastolic Heart Failure
    Ali Ahmed; Fiscal Year: 2010
    ..We base our hypothesis on the observations that despite differences in nature of left ventricular dysfunction, the pathogenesis (including neurohormonal activation), clinical presentation, and outcomes in systolic ..
  24. A Pilot Clinical Study in Acute STEMI
    Weizhong Cai; Fiscal Year: 2011
    ..significant clinical interest is our finding that delayed BB3 administration also attenuates post-infarct ventricular dysfunction in both rat and pig...
  25. Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients
    Nader Najafi; Fiscal Year: 2013
    ..obstruction within the pulmonary vasculature, elevated pulmonary vascular resistance, or significant ventricular dysfunction can result in patients having elevated hemi-Fontan pressures...
  26. Computational Tools to Describe Cardiac Post-MI Structure and Function Remodeling
    Siamak Ardekani; Fiscal Year: 2012
    ..For example, in patients with coronary artery disease and left ventricular dysfunction, ventricular remodeling results in a gradual increase of ventricular end-diastolic and end- systolic ..
  27. Connexin 43 gap junction dynamics in the diabetic heart
    Joseph A Palatinus; Fiscal Year: 2013
    ..risk of fatal arrhythmias, decreased recovery after a myocardial insult, and a cardiomyopathy leading to ventricular dysfunction independent of arteriolosclerosis and hypertension...
  28. Electro-mechanical Resynchronization Therapy For Arrhythmogenic Right Ventricular
    Harikrishna Tandri; Fiscal Year: 2012
    ..Recent studies have highlighted the role of dyssynchrohous electrical activation in left ventricular dysfunction associated with LBBB, and for this disorder, bi-ventricular pacing or cardiac resynchronization therapy ..
  29. The molecular mechanisms underlying arrhythmogenic right ventricular dysplasia/ca
    Farah Sheikh; Fiscal Year: 2013
    ..is a genetic form of cardiomyopathy, which is typically characterized by right but also recently left ventricular dysfunction, fibrotic/fatty replacement of the ventricle and ventricular arrhythmias leading to sudden cardiac death...
  30. Genetics of gene expression in human left ventricular myocardium
    Jochen Daniel Muehlschlegel; Fiscal Year: 2013
    ..be genotyped and tested for association with perioperative myocardial injury, all-cause mortality and ventricular dysfunction in this very well phenotyped cohort...
  31. ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPS
    SUSAN S REDLINE; Fiscal Year: 2013
    ..For example, African Americans have a considerably higher prevalence of hypertension, left ventricular dysfunction, and heart failure than Caucasians despite lipid patterns and coronary artery calcium levels that ..
  32. Exercise and TZD Effects on Myocardial Substrate Metabolism and Function in HIV
    William Todd Cade; Fiscal Year: 2010
    ..glucose utilization and elevated peripheral and myocardial FFA oxidation is associated with left ventricular dysfunction. Furthermore, both GET and TZD treatment will improve ventricular function through an increase of ..
  33. Heart failure, chronic kidney disease, and renin-angiotensin system inhibition
    Ali Ahmed; Fiscal Year: 2009
    ..In addition, Studies of Left Ventricular Dysfunction (SOLVD) (N=2569;83 hospitals;mean age 61 years, 20% women, 20% nonwhite) data will be use to study the ..
  34. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
    ..The sequence of the molecular and cellular events that result in coronary sclerosis and ventricular dysfunction following TBI is not known...
  35. Cellular Cardiomyoplasty for Chronic Heart Failure
    Joshua M Hare; Fiscal Year: 2013
    ..potential to regenerate new myocardium and decrease progression of heart failure in patients with left ventricular dysfunction due to healed myocardial infarction...
  36. FAK signaling in cardiac growth and hypertrophy
    Joan M Taylor; Fiscal Year: 2013
    ..to divide, thus, injury to the heart typically causes permanent loss of muscle mass leading to ventricular dysfunction and heart failure...
  37. Data Coordinating Center for VEST and PREDICTS
    Stephen B Hulley; Fiscal Year: 2010
    ..vest will reduce overall mortality during the first 60 days following an Ml in patients with left ventricular dysfunction (EF<35%)...
  38. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    ..In the second model, we will study the efficacy of SEW 2871 on ventricular dysfunction caused by ligation of the left anterior descending coronary artery in mice...
  39. In-vivo Imaging of Calcium in the Heart
    Barry London; Fiscal Year: 2010
    ..Abnormalities in Ca2+ handling accompany most types of cardiac pathology, and may contribute to both ventricular dysfunction and arrhythmias...
  40. REGULATION OF ADENYLYL CYCLASE SIGNALING PATHWAYS
    Carmen W Dessauer; Fiscal Year: 2013
    ..However, chronic activation of the cAMP pathway induces hypertrophic growth and ventricular dysfunction, which ultimately leads to the development of chamber dilatation and heart failure...
  41. Aging and Homeostasis of Cardiac Stem Cell Niches
    Annarosa Leri; Fiscal Year: 2010
    ..Conversely, resistance to apoptosis accelerates cardiac aging and the onset of ventricular dysfunction. With age, CSCs-ECCs clustered in the niches may become less susceptible to apoptosis, less prone to re-..
  42. Xanthine Oxidase and Bioenergetic Function in Volume Overload
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Mechanisms of left ventricular dysfunction in models of volume overload are not well understood and there is currently no recommended medical ..
  43. ECHOCARDIOGRAPHY READING CENTER
    Scott Solomon; Fiscal Year: 2013
    ..clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants ..
  44. ECHOCARDIOGRAPHY READING CENTER
    Scott Solomon; Fiscal Year: 2012
    ..clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants ..
  45. 3D MRI-Based Modeling for Computer-Aided Right Ventricle Remodeling Surgery
    Dalin Tang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Right ventricular dysfunction developing late after congenital cardiac surgery is one of the most common causes of heart failure in adults with congenital heart disease...
  46. Probing the Atrial Arrhythmogenic Substrate with Sustained Adrenergic Stimulation
    Brian R Overholser; Fiscal Year: 2013
    ..Specific Aim 2 will test electrophysiological mechanisms for atrial arrhythmogenesis during left ventricular dysfunction by assessing the interplay of focal triggers and reentrant mechanisms...
  47. Clinical and Genetic Evaluation of Donors for Cardiac Transplantation
    KIRAN KAUR KHUSH; Fiscal Year: 2013
    ..resources available at Stanford University to identify clinical and genetic risk factors for graft left ventricular dysfunction (Aim 1), to identify donor clinical and genetic predictors of poor recipient outcomes after ..
  48. AGING OF THE HEART
    Piero Anversa; Fiscal Year: 2013
    ..aging of small (Projects 1 and 2) and large (Project 3) animals and humans (Project 4) will be investigated in an integrated manner to identify the variables that lead to ventricular dysfunction in the old heart.
  49. Nkx2.5-dependent pathways in postnatal cardiomyocytes
    Hideko Kasahara; Fiscal Year: 2009
    ..5 cause progressive conduction defects, various cardiac anomalies and occasional left ventricular dysfunction suggesting that this transcription factor plays important roles in formation of the developing heart as ..
  50. CLINICAL EXAMINATION CENTER
    Josef Coresh; Fiscal Year: 2013
    ..clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants ..
  51. ARIC CORC
    SALLY STEARNS; Fiscal Year: 2013
    ..clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants ..
  52. CENTRAL LABORATORY CENTER
    Christie Ballantyne; Fiscal Year: 2013
    ..clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants ..
  53. ARIC CLINICAL EXAMINATION CENTER
    Gerardo Heiss; Fiscal Year: 2012
    ..clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants ..
  54. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2003
    DESCRIPTION (Adapted from the applicant's abstract):Left ventricular dysfunction (LVD) is a syndrome which presents as dyspnea on exertion, wheezing, a rapid respiratory rate, and increased secretion of mucus...
  55. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ..S. One important determinant of early and late mortality is the extent of left ventricular dysfunction. Although early reperfusion by either pharmacologic or mechanical means has been conclusively shown to ..
  56. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2002
    ..with the immediate transition from MV to SpV due to hemodynamic instability caused by pre-existing left ventricular dysfunction. The purpose of this study is to examine interventions to optimize the cardiopulmonary (CP) hemodynamic ..
  57. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    ..abstract_text> ..
  58. REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Julius Guccione; Fiscal Year: 1999
    The global left ventricular dysfunction that is characteristic of left ventricular aneurysm (LVA) is associated with stretching of muscle fibers in the adjacent noninfarcted (border zone) region during isovolumic systole...
  59. Labeled inhibitors for angiotensin converting enzyme
    John Babich; Fiscal Year: 2004
    ..failure is associated with poor morbidity and mortality; the more severe the clinical failure and left ventricular dysfunction, the worse the prognosis...
  60. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2004
    ..Quantification of gene expression of angiogenic factors, mediators of inflammation, and markers of left ventricular dysfunction will be performed by Real Time PCR on the endomyocardial biopsy samples...
  61. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2002
    ..Quantification of gene expression of angiogenic factors, mediators of inflammation, and markers of left ventricular dysfunction will be performed by Real Time PCR on the endomyocardial biopsy samples...
  62. Angiogenesis in a model of diabetes and endothelial dysfunction
    Frank Sellke; Fiscal Year: 2009
    ..VEGF) and fibroblast growth factor-2 (FGF-2), which has been shown to improve coronary flow and left ventricular dysfunction in numerous animal models, is a particularly attractive therapeutic option for diabetic patients with end-..
  63. Aging and Heart Failure are not Similar Syndromes of Sympathetic Dysregulation
    MICHAEL KENNEY; Fiscal Year: 2009
    ..nerve discharge (SND) responses to acute stress in young and old rats with the same degree of left ventricular dysfunction and congestive HF, despite evidence demonstrating diversity in mechanisms regulating physiological ..
  64. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..of these adverse outcomes are related to the cardiac consequences of the infarct itself, namely left ventricular dysfunction, cardiogenic shock, and congestive heart failure; in spite of the fact that indices of infarct size tend ..
  65. In Vivo Measurement of Myocardial Oxygen Consumption
    BRIGITTE PONCELET; Fiscal Year: 2004
    ..Failure of the heart to convert oxygen into work is found in various forms of ventricular dysfunction unrelated to coronary disease (hypertrophy, cardiomyopathy)...