myocardial infarction

Summary

Summary: Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area. (Dorland, 27th ed)

Top Publications

  1. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
  2. ncbi Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  3. pmc Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
    Benjamin F Voight
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Lancet 380:572-80. 2012
  4. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  5. pmc Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:13027-32. 2008
  6. pmc A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction
    Joshua M Hare
    Department of Medicine, Cardiovascular Division and the Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Am Coll Cardiol 54:2277-86. 2009
  7. ncbi Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
  8. doi Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans
    Guo Kun Wang
    Department of Cardiology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, People s Republic of China
    Eur Heart J 31:659-66. 2010
  9. doi Prospective study on circulating MicroRNAs and risk of myocardial infarction
    Anna Zampetaki
    King s British Heart Foundation Centre, King s College London, United Kingdom
    J Am Coll Cardiol 60:290-9. 2012
  10. ncbi Explaining the decrease in U.S. deaths from coronary disease, 1980-2000
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 356:2388-98. 2007

Detail Information

Publications266 found, 100 shown here

  1. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  2. ncbi Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  3. pmc Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
    Benjamin F Voight
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Lancet 380:572-80. 2012
    High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear...
  4. ncbi Myocardial reperfusion injury
    Derek M Yellon
    Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, United Kingdom
    N Engl J Med 357:1121-35. 2007
  5. pmc Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:13027-32. 2008
    Acute myocardial infarction (MI) due to coronary artery occlusion is accompanied by a pathological remodeling response that includes hypertrophic cardiac growth and fibrosis, which impair cardiac contractility...
  6. pmc A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction
    Joshua M Hare
    Department of Medicine, Cardiovascular Division and the Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Am Coll Cardiol 54:2277-86. 2009
    Our aim was to investigate the safety and efficacy of intravenous allogeneic human mesenchymal stem cells (hMSCs) in patients with myocardial infarction (MI).
  7. ncbi Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure.
  8. doi Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans
    Guo Kun Wang
    Department of Cardiology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, People s Republic of China
    Eur Heart J 31:659-66. 2010
    ..We aim to determine the potential of cardiac-specific miRNAs in circulation to serve as biomarkers for acute myocardial infarction (AMI).
  9. doi Prospective study on circulating MicroRNAs and risk of myocardial infarction
    Anna Zampetaki
    King s British Heart Foundation Centre, King s College London, United Kingdom
    J Am Coll Cardiol 60:290-9. 2012
    This study sought to explore the association between baseline levels of microRNAs (miRNAs) (1995) and incident myocardial infarction (1995 to 2005) in the Bruneck cohort and determine their cellular origin.
  10. ncbi Explaining the decrease in U.S. deaths from coronary disease, 1980-2000
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 356:2388-98. 2007
    ..We conducted a study to determine how much of this decrease could be explained by the use of medical and surgical treatments as opposed to changes in cardiovascular risk factors...
  11. ncbi Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    Christopher P Cannon
    Thrombolysis in Myocardial Infarction TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 350:1495-504. 2004
    ..Lipid-lowering therapy with statins reduces the risk of cardiovascular events, but the optimal level of low-density lipoprotein (LDL) cholesterol is unclear...
  12. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  13. ncbi Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    D H O'Leary
    Department of Radiology, Tufts New England Medical Center, Boston, MA, USA
    N Engl J Med 340:14-22. 1999
    ..We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease.
  14. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
    ..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
  15. pmc Circulating microRNAs are new and sensitive biomarkers of myocardial infarction
    Yuri D'Alessandra
    Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Eur Heart J 31:2765-73. 2010
    Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice.
  16. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Circulation 116:2634-53. 2007
  17. pmc The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 204:3037-47. 2007
    Healing of myocardial infarction (MI) requires monocytes/macrophages...
  18. pmc Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat
    Baoyin Zhao
    Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    J Cell Mol Med 17:123-33. 2013
    ..the functional role of cardiac telocytes and possible changes in the cardiac telocyte population during myocardial infarction in the myocardium are not known...
  19. pmc A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse
    Erhe Gao
    Center for Translational Medicine, George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Thomas Jefferson University, 1025 Walnut St, Room 302, Philadelphia, PA 19107, USA
    Circ Res 107:1445-53. 2010
    coronary artery ligation to induce myocardial infarction (MI) in mice is typically performed by an invasive and time-consuming approach that requires ventilation and chest opening (classic method), often resulting in extensive tissue ..
  20. ncbi The inflammatory response in myocardial infarction
    Nikolaos G Frangogiannis
    Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
    Cardiovasc Res 53:31-47. 2002
    ..is to design strategies aimed at minimizing myocardial necrosis and optimizing cardiac repair following myocardial infarction. However, a sound understanding of the biology is necessary before a specific intervention is pursued on a ..
  21. pmc Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Stem Cell 5:54-63. 2009
    ..After myocardial infarction, i.v...
  22. doi 10-year follow-up of intensive glucose control in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    N Engl J Med 359:1577-89. 2008
    ..We conducted post-trial monitoring to determine whether this improved glucose control persisted and whether such therapy had a long-term effect on macrovascular outcomes...
  23. ncbi Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    Shao Liang Chen
    Division of Cardiology, Nanjing First Hospital, Nanjing University, Nanjing, Jiangsu Province, China
    Am J Cardiol 94:92-5. 2004
    ..patients who underwent primary percutaneous coronary intervention within 12 hours after onset of acute myocardial infarction were randomized to receive intracoronary injection of autologous bone marrow mesenchymal stem cell or ..
  24. pmc Paracrine mechanisms in adult stem cell signaling and therapy
    Massimiliano Gnecchi
    Mandel Center for Hypertension Research, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 103:1204-19. 2008
    Animal and preliminary human studies of adult cell therapy following acute myocardial infarction have shown an overall improvement of cardiac function...
  25. doi Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    Lars Wallentin
    Uppsala Clinical Research Center, Uppsala, Sweden
    N Engl J Med 361:1045-57. 2009
    ..Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel...
  26. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
    ..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
  27. ncbi Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials
    Ellen C Keeley
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Lancet 361:13-20. 2003
    ..transluminal coronary angioplasty (PTCA) with thrombolytic therapy for acute ST-segment elevation myocardial infarction (AMI)...
  28. ncbi Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
    b>Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time...
  29. pmc Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction
    Christopher J O'Donnell
    MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Circulation 124:2855-64. 2011
    ..by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI)...
  30. pmc Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction
    Guangwen Long
    Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Biol Sci 8:811-8. 2012
    ..was to clarify that circulating miR-1 and miR-126 in human plasma might be useful as biomarkers in acute myocardial infarction (AMI). In our study, after pre-test, two candidate miRNAs were detected by using real-time RT-PCR...
  31. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  32. ncbi Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    C Baigent
    Lancet 366:1267-78. 2005
    ..But each separate trial has limited power to assess particular outcomes or particular categories of participant...
  33. ncbi The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making
    E M Antman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 284:835-42. 2000
    Patients with unstable angina/non-ST-segment elevation myocardial infarction (MI) (UA/NSTEMI) present with a wide spectrum of risk for death and cardiac ischemic events.
  34. ncbi Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    Bertram Pitt
    University of Michigan, Ann Arbor, USA
    N Engl J Med 348:1309-21. 2003
    ..placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure.
  35. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Gade 2, DK 8000 Aarhus C, Denmark
    J Am Coll Cardiol 50:2173-95. 2007
  36. pmc Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Science 339:161-6. 2013
    ..inflammatory process of lipid-rich lesion growth in the vascular wall that can cause life-threatening myocardial infarction (MI)...
  37. pmc Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis
    C G Manole
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    J Cell Mol Med 15:2284-96. 2011
    We used rat experimental myocardial infarction to study the ultrastructural recovery, especially neo-angiogenesis in the infarction border zone...
  38. doi Effect of cyclosporine on reperfusion injury in acute myocardial infarction
    Christophe Piot
    Hopital Arnaud de Villeneuve, Montpellier, France
    N Engl J Med 359:473-81. 2008
    ..In this pilot trial, we sought to determine whether the administration of cyclosporine at the time of percutaneous coronary intervention (PCI) would limit the size of the infarct during acute myocardial infarction.
  39. pmc 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 168:1174-80. 2008
    ..Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans...
  40. pmc Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease
    Virginia A Triant
    Massachusetts General Hospital Program in Nutritional Metabolism, Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:2506-12. 2007
    ..Metabolic changes and smoking are common among HIV patients and may confer increased cardiovascular risk...
  41. doi Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction
    Jing Ai
    The Department of Pharmacology, Harbin Medical University, Harbin 150081, PR China
    Biochem Biophys Res Commun 391:73-7. 2010
    ..However, whether miR-1 could be a biomarker for predicting acute myocardial infarction (AMI) is unclear...
  42. ncbi Homocysteine lowering and cardiovascular events after acute myocardial infarction
    Kaare Harald Bønaa
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    N Engl J Med 354:1578-88. 2006
    Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction.
  43. ncbi Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure
    Yuji Okura
    Division of Cardiovascular Diseases and Internal Medicine, Department of Health Science Research, Mayo Clinic and Foundation, 200 First St SW, Rochester, Minnesota 55905, USA
    J Clin Epidemiol 57:1096-103. 2004
    ..Agreement between questionnaire responses and a criterion standard is important for optimal disease prevalence estimates. We measured the agreement between self-reported disease and medical record diagnosis of disease...
  44. pmc MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue
    Sashwati Roy
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, Columbus, OH 43210, USA
    Cardiovasc Res 82:21-9. 2009
    ..For the first time, we sought to test how myocardial ischaemia-reperfusion (IR) changes miR expression...
  45. ncbi Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    P M Ridker
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 101:1767-72. 2000
    ..Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse...
  46. ncbi Pathology of the vulnerable plaque
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 47:C13-8. 2006
    The majority of patients with acute coronary syndromes (ACS) present with unstable angina, acute myocardial infarction, and sudden coronary death...
  47. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Aarhus C, Denmark
    Eur Heart J 28:2525-38. 2007
  48. pmc Regulation of the inflammatory response in cardiac repair
    Nikolaos G Frangogiannis
    Family Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 110:159-73. 2012
    ..of the postinfarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction. This review manuscript discusses the cellular effectors and endogenous molecular signals implicated in ..
  49. ncbi Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    Peter Ferdinandy
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dom ter 9, Szeged, H 6720, Hungary
    Pharmacol Rev 59:418-58. 2007
    ..Reperfusion is the definitive treatment for acute coronary syndromes, especially acute myocardial infarction; however, reperfusion has the potential to exacerbate lethal tissue injury, a process termed "reperfusion ..
  50. ncbi Risk of myocardial infarction and stroke after acute infection or vaccination
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    N Engl J Med 351:2611-8. 2004
    ..There is evidence that chronic inflammation may promote atherosclerotic disease. We tested the hypothesis that acute infection and vaccination increase the short-term risk of vascular events...
  51. doi Population trends in the incidence and outcomes of acute myocardial infarction
    Robert W Yeh
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    N Engl J Med 362:2155-65. 2010
    Few studies have characterized recent population trends in the incidence and outcomes of myocardial infarction.
  52. pmc Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction
    Hidemasa Oh
    Center for Cardiovascular Development, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:12313-8. 2003
    ..By using a Cre/Lox donor/recipient pair (alphaMHC-Cre/R26R), differentiation was shown to occur roughly equally, with and without fusion to host cells...
  53. ncbi Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction
    Nagesh S Anavekar
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1285-95. 2004
    The presence of coexisting conditions has a substantial effect on the outcome of acute myocardial infarction. Renal failure is associated with one of the highest risks, but the influence of milder degrees of renal impairment is less well ..
  54. pmc Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study
    Emily Herrett
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    BMJ 346:f2350. 2013
    To determine the completeness and diagnostic validity of myocardial infarction recording across four national health record sources in primary care, hospital care, a disease registry, and mortality register.
  55. doi Use of circulating microRNAs to diagnose acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public, santé, Luxembourg
    Clin Chem 58:559-67. 2012
    Rapid and correct diagnosis of acute myocardial infarction (MI) has an important impact on patient treatment and prognosis...
  56. doi 25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies
    Peter Brøndum-Jacobsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Arterioscler Thromb Vasc Biol 32:2794-802. 2012
    We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death.
  57. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  58. doi Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Hei
    Kuanrong Li
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Heart 98:920-5. 2012
    ..However, findings of an ultimately decreased risk of cardiovascular disease (CVD) are limited. Instead, recent evidence warns that taking calcium supplements might increase myocardial infarction (MI) risk.
  59. doi Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    Jacob Lønborg
    Department of Cardiology, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Eur Heart J 33:1491-9. 2012
    ..We evaluated the cardioprotective effect of exenatide at the time of reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI).
  60. doi Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease
    Patrick W Serruys
    Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    N Engl J Med 360:961-72. 2009
    ..Our trial compared PCI and CABG for treating patients with previously untreated three-vessel or left main coronary artery disease (or both)...
  61. pmc Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
    Lancet 379:895-904. 2012
    Cardiosphere-derived cells (CDCs) reduce scarring after myocardial infarction, increase viable myocardium, and boost cardiac function in preclinical models...
  62. doi Plasma microRNA 499 as a biomarker of acute myocardial infarction
    Taichi Adachi
    Department of Cardiology, National Cardiovascular Center, Suita, Osaka, Japan
    Clin Chem 56:1183-5. 2010
    ..In the present study, we assessed the hypothesis that plasma concentrations of myocardial-specific miRNAs can be used to diagnose myocardial injury in humans...
  63. ncbi Combination antiretroviral therapy and the risk of myocardial infarction
    Nina Friis-Møller
    N Engl J Med 349:1993-2003. 2003
    It remains controversial whether exposure to combination antiretroviral treatment increases the risk of myocardial infarction.
  64. ncbi Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery
    Jeffrey W Moses
    Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute of New York, New York 10021, USA
    N Engl J Med 349:1315-23. 2003
    ..Preliminary reports of studies involving simple coronary lesions indicate that a sirolimus-eluting stent significantly reduces the risk of restenosis after percutaneous coronary revascularization...
  65. ncbi Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study
    Annika Rosengren
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Lancet 364:953-62. 2004
    ..The aim of the present analysis was to investigate the relation of psychosocial factors to risk of myocardial infarction in 24767 people from 52 countries.
  66. pmc A translational study of circulating cell-free microRNA-1 in acute myocardial infarction
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Clin Sci (Lond) 119:87-95. 2010
    ..and to determine the potential applications of circulating cell-free miR-1 (microRNA-1) in AMI (acute myocardial infarction)...
  67. pmc Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
    Luciano C Amado
    Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11474-9. 2005
    ..First, cells were safely injected by using a percutaneous-injection catheter 3 d after myocardial infarction. Second, cellular transplantation resulted in long-term engraftment, profound reduction in scar formation, ..
  68. ncbi Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    Michael A Laflamme
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Nat Biotechnol 25:1015-24. 2007
    ..myocardium attenuated ventricular dilation and preserved regional and global contractile function after myocardial infarction compared with controls receiving noncardiac hES cell derivatives or vehicle...
  69. ncbi Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction
    Ketil Lunde
    Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    N Engl J Med 355:1199-209. 2006
    ..function after intracoronary injection of autologous cells derived from bone marrow (BMC) in the acute phase of myocardial infarction. We designed a randomized, controlled trial to further investigate the effects of this treatment.
  70. doi Myocardial remodeling after infarction: the role of myofibroblasts
    Susanne W M van den Borne
    Cardiovascular Research Institute Maastricht, Department of Pharmacology and Toxicology and Cardiology, Maastricht University, Maastricht, The Netherlands
    Nat Rev Cardiol 7:30-7. 2010
    ..lead to cardiac stiffness, an inevitable process of myocardial remodeling that occurs in the aftermath of myocardial infarction and constitutes the basis of the development of heart failure...
  71. pmc Nerve growth factor promotes cardiac repair following myocardial infarction
    Marco Meloni
    Experimental Cardiovascular Medicine Division, Bristol Heart Institute, Bristol, United Kingdom
    Circ Res 106:1275-84. 2010
    ..Nerve growth factor (NGF) promotes angiogenesis and cardiomyocyte survival, which are both desirable for postinfarction myocardial healing. Nonetheless, the NGF potential for cardiac repair has never been investigated...
  72. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..of both phase-sensitive IR image reconstruction and surface coil intensity normalization for detecting myocardial infarction (MI)...
  73. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
    ..single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) for association with early-onset myocardial infarction in 2,967 cases and 3,075 controls...
  74. ncbi Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  75. doi Genetic determinants of response to clopidogrel and cardiovascular events
    Tabassome Simon
    Assistance Publique Hopitaux de Paris, Hopital Saint Antoine, and Universite Pierre et Marie Curie, Paris 06, France
    N Engl J Med 360:363-75. 2009
    ..The effect of these determinants on clinical outcomes after an acute myocardial infarction is unknown.
  76. ncbi Optimal medical therapy with or without PCI for stable coronary disease
    William E Boden
    Western New York Veterans Affairs Healthcare Network and Buffalo General Hospital SUNY, Buffalo, NY 14203, USA
    N Engl J Med 356:1503-16. 2007
    ....
  77. doi n-3 fatty acids and cardiovascular events after myocardial infarction
    Daan Kromhout
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    N Engl J Med 363:2015-26. 2010
    ..effect of the marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and of the plant-derived alpha-linolenic acid (ALA) on the rate of cardiovascular events among patients who have had a myocardial infarction.
  78. ncbi Isolation and expansion of adult cardiac stem cells from human and murine heart
    Elisa Messina
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Circ Res 95:911-21. 2004
    ..and can differentiate in vitro and after ectopic (dorsal subcutaneous connective tissue) or orthotopic (myocardial infarction) transplantation in SCID beige mouse to yield the major specialized cell types of the heart: myocytes (ie, ..
  79. ncbi Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    Bodo E Strauer
    Department of Medicine, Division of Cardiology, Heinrich Heine University of Dusseldorf, Germany
    Circulation 106:1913-8. 2002
    Experimental data suggest that bone marrow-derived cells may contribute to the healing of myocardial infarction (MI)...
  80. ncbi Mesenchymal stem cells and their potential as cardiac therapeutics
    Mark F Pittenger
    Osiris Therapeutics, Inc, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Circ Res 95:9-20. 2004
    ....
  81. ncbi The validity of the diagnosis of acute myocardial infarction in routine statistics: a comparison of mortality and hospital discharge data with the Danish MONICA registry
    Mette Madsen
    National Institute of Public Health, Svanemøllevej 25, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 56:124-30. 2003
    We analyzed the validity of the diagnosis of acute myocardial infarction (MI) in national registries by individual record linkage with the Danish MONICA registry...
  82. ncbi Plasma adiponectin levels and risk of myocardial infarction in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Channing Laboratory, Boston, Mass 02115, USA
    JAMA 291:1730-7. 2004
    ..Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans...
  83. ncbi Monitoring of bone marrow cell homing into the infarcted human myocardium
    Michael Hofmann
    Department of Nuclear Medicine, Hanover Medical School, Hanover, Germany
    Circulation 111:2198-202. 2005
    ..bone marrow cells (BMCs) promotes recovery of left ventricular systolic function in patients with acute myocardial infarction. Although the mechanisms of this effect remain to be established, homing of BMCs into the infarcted ..
  84. pmc Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    Konstantinos E Hatzistergos
    University of Miami Miller School of Medicine, Interdisciplinary Stem Cell Institute, Miami, FL 33136, USA
    Circ Res 107:913-22. 2010
    ..Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into cardiac myocytes...
  85. pmc Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    Cardiovasc Res 87:431-9. 2010
    ....
  86. doi Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    Kevin Bersell
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Cell 138:257-70. 2009
    ..cardiomyocyte cell-cycle activity and promotes myocardial regeneration, leading to improved function after myocardial infarction. Undifferentiated progenitor cells did not contribute to NRG1-induced cardiomyocyte proliferation...
  87. ncbi Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
    Birgit Assmus
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 106:3009-17. 2002
    ..The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown...
  88. ncbi Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction
    Volker Schachinger
    Department of Internal Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1210-21. 2006
    Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction.
  89. doi Vorapaxar in the secondary prevention of atherothrombotic events
    David A Morrow
    Thrombolysis in Myocardial Infarction TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 366:1404-13. 2012
    ..Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1...
  90. pmc Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
    Muredach P Reilly
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Lancet 377:383-92. 2011
    We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis.
  91. ncbi PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans
    G Peri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 102:636-41. 2000
    ..The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested.
  92. doi Comparison of zotarolimus-eluting and everolimus-eluting coronary stents
    Patrick W Serruys
    Department of Cardiology, Erasmus Medical Center, Molewaterplein 40, Ba 583, 3015 GD Rotterdam, The Netherlands
    N Engl J Med 363:136-46. 2010
    ..However, it is unclear whether there are differences in efficacy and safety between the two types of stents on the basis of prospectively adjudicated end points endorsed by the Food and Drug Administration...
  93. doi Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE
    Alexander Hirsch
    Department of Cardiology, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Eur Heart J 32:1736-47. 2011
    Previous trials that investigated cell therapy as an adjunctive therapy after acute myocardial infarction (AMI) have shown conflicting results...
  94. pmc Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial
    Samer S Najjar
    Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    JAMA 305:1863-72. 2011
    Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function.
  95. pmc Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Antioxid Redox Signal 14:781-90. 2011
    ..We provide novel evidence for a profound-but potentially reversible-diabetes-induced defect in the cardioprotective efficacy of PostC...
  96. doi Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study
    J O Beitnes
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Norway
    Heart 95:1983-9. 2009
    To investigate long-term safety and efficacy after intracoronary injection of autologous mononuclear bone marrow cells (mBMCs) in acute myocardial infarction (AMI).
  97. doi Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:342-7. 2009
    ..2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
  98. doi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  99. doi Intracoronary bone marrow cell transfer after myocardial infarction: 5-year follow-up from the randomized-controlled BOOST trial
    Gerd P Meyer
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 30:2978-84. 2009
    ..can have a sustained impact on left ventricular ejection fraction (LVEF) in patients after ST-elevation myocardial infarction (STEMI)...
  100. pmc Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRI
    Steffen Bohl
    BHF Experimental MR Unit, Wellcome Trust Centre for Human Genetics, Univ of Oxford, Roosevelt Dr, Oxford, OX3 7BN, United Kingdom
    Am J Physiol Heart Circ Physiol 296:H1200-8. 2009
    Conventional methods to quantify infarct size after myocardial infarction in mice are not ideal, requiring either tissue destruction for histology or relying on nondirect measurements such as wall motion...
  101. doi Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    Philip D Home
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, UK
    Lancet 373:2125-35. 2009
    ..We assessed cardiovascular outcomes after addition of rosiglitazone to either metformin or sulfonylurea compared with the combination of the two over 5-7 years of follow-up. We also assessed comparative safety...

Research Grants82

  1. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
    ..IPC) and hyperthermia (HT) are known to offer cardioprotection from ischemic injury such as myocardial infarction. While HT induces the heat shock proteins (HSP), which can act as chaperones in preventing myocardial ..
  2. Transforming PCI Informed Consent into an Evidence-based Decision-making Tool
    John A Spertus; Fiscal Year: 2010
    ..Bleeding is the most common, non-cardiac complication of PCI and is strongly associated with myocardial infarction (heart attack), stroke, increased length of stay/costs and death...
  3. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..In particular, the care of acute myocardial infarction has now been transformed by reperfusion therapy, which in most large community hospitals, provides faster, ..
  4. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..Recent evidence indicates that untreated OSA carries increased risk for the development of hypertension, myocardial infarction, and stroke...
  5. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..proposal provides the NHLBI with the opportunity to capitalize on an existing large South Asian myocardial infarction (MI) case-control study in which subjects have already been genome-wide genotyped...
  6. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..women is exacerbated by evidence indicating that post-menopausal women have higher mortality rates after myocardial infarction vs aged men, and it is unclear whether the effects of aging and estrogen (E2) deficiency are additive with ..
  7. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..represent the first evaluation of sEH inhibitors as a prophylaxis against, and a therapeutic treatment of, myocardial infarction. Potential Impact on Veteran's Health Care...
  8. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..Atherosclerosis is the most prevalent pathologic process leading to cardiovascular disease, including myocardial infarction and stroke - the number-one killers in the western hemisphere...
  9. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..of many clinical events such as organ transplants, cardiopulmonary bypass (CPB) used in cardiac surgery, myocardial infarction (MI), and stroke. There is currently no effective therapy to prevent or reduce IRI...
  10. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..GSK-3b is upregulated and GSK-3a is downregulated ex vivo facilitates the recovery of the heart after myocardial infarction (MI) through stimulation of cardiomyocyte differentiation and angiogenesis...
  11. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..expression of GRP-78 and Gadd153 and activation of caspase-12 was also observed in the heart following myocardial infarction (MI). Inhibition of GSK-32 inhibited 2-AR-stimulated increases in Gadd153 levels...
  12. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..g., myocardial infarction, cardiac arrhythmias, contractile dysfunction)...
  13. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The common cellular event that defines both myocardial infarction and the progression from compensated cardiac hypertrophy to decompensated heart failure is death of cardiomyocytes...
  14. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..prothrombinase complex contributes significantly to the pathogenesis of common clinical disorders such as myocardial infarction, deep vein thrombosis, pulmonary embolism, and stroke...
  15. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010
    ..S. Chronic arsenic ingestion causes atherosclerosis and is associated with increased mortality from myocardial infarction and stroke...
  16. Effectiveness and Safety of Antithrombotic Strategies after Joint Replacement
    Elaine Hylek; Fiscal Year: 2013
    ..VTE is the third leading cause of cardiovascular death after myocardial infarction and stroke...
  17. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): A Novel Regenerative Therapy for Myocardial Infarction Myocardial infarction (MI) is an acute public health problem killing one third of the 1.5 million Americans afflicted annually...
  18. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..These plaques often rupture, causing myocardial infarction, stroke, or death. The main risk factors include elevated lipid levels, hypertension, and diabetes...
  19. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..many cardiovascular diseases including: hypertension, stroke, coronary artery disease, cardiomyopathies, myocardial infarction, congestive heart failure, and sudden cardiac death...
  20. NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
    Vijay Sharma; Fiscal Year: 2013
    ..Successful execution of the outlined objectives should provide a molecular-targeted 68Ga-PET agent for MPI and management of CAD. ..
  21. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..the capability of transplanted UCB-MSCs obtained by the ECM adhesion to improve heart function after myocardial infarction (MI) using a well-established mouse model...
  22. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..These plaques often rupture, causing myocardial infarction, stroke, or death. The main risk factors include elevated lipid levels, hypertension, and diabetes...
  23. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..3 major hypotheses that we will investigate are: (1) lower melatonin production is associated with CVD (myocardial infarction [MI] and stroke) and T2DM;(2) common variants in circadian genes are associated with CVD and T2DM, and the ..
  24. Mitochondrial Mechanisms of Programmed Necrosis in the Aged Female Heart
    Alexandra M Machikas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute myocardial infarction (AMI) is the leading cause of death among aged Americans, with increased mortality in postmenopausal women compared to age-matched men...
  25. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    ..provided by applicant): Patients with Diabetes Mellitus (DM) have a higher incidence of death after myocardial infarction (MI) than do non-diabetic patients...
  26. microRNA mediation of Endothelial Progenitor Cell function in Myocardial Ichemia
    Prasanna Krishnamurthy; Fiscal Year: 2013
    ..of number of miRNAs related to cell survival/death and angiogenesis with a robust increase in miR-377, 3) myocardial infarction (MI) increased miR-377 expression in the myocardium, circulating EPCs and plasma, 3d post-MI;4) pre-miR-..
  27. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
    ..dipyridamole and treadmill stress tests independently predict survival or all-cause mortality, subsequent myocardial infarction (MI), or coronary revascularization alone and in combination, after adjustment for demographic, clinical, ..
  28. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..If we can avoid the untimely presence of these cells in ischemia, heart failure after myocardial infarction would then be diminished.
  29. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..In Specific Aim 1, we will study effects of the selective S1P1 receptor agonist SEW 2871 in two models of myocardial infarction. Model 1 is the Scavenger Receptor Class B Type I-deficient, hypomorphic apolipoprotein ER61 (SR- BI KO/..
  30. Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathy
    John P Konhilas; Fiscal Year: 2013
    ..differences exist in human cardiac disease resulting from many disease etoilogies including hypertension, myocardial infarction, and hypertrophic cardiomyopathy (HCM)...
  31. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2012
    ..In this application, we propose to develop a novel bioreducible polymer to deliver VEGF gene to primary myoblasts for the treatment of acute myocardial infarct to address these short- comings of current therapeutic strategies. ..
  32. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ..Preliminary data using the MBL assay in patients undergoing thrombolytic therapy for myocardial infarction demonstrate significantly higher MBL levels in MI patients that have died within the first 30 days of ..
  33. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..important factor in acute thrombotic complications of atherosclerosis such as stable and unstable angina, myocardial infarction, and ischemic stroke, it could be a key mediator of the cardiovascular toxicity associated with PM ..
  34. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute myocardial infarction is a leading cause of death throughout the world, while stroke is the third leading cause of death in the United States...
  35. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute myocardial infarction is the leading cause of death in most industrialized nations...
  36. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    ..will lead to (a) effective novel pharmacologic approaches to prevent apoptotic death in settings such as myocardial infarction and stroke and hemoprotein mediated oxidative damage in settings of subarachnoid hemorrhage and ..
  37. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2011
    ..via biochemical analysis, mathematical modeling, and systemic experiments in rats including the effect on myocardial infarction. Project 2 will examine PEG-Hbs' effects on the glycocalyx integrity, how PEG-Hbs'presence ..
  38. Remodeling of the guinea pig intrinsic cardiac plexus with chronic heart disease
    ELIZABETH MARIE SOUTHERLAND; Fiscal Year: 2013
    ..how the elements of the ICN adapt to chronic disease using two different animal models of heart disease: myocardial infarction (MI) and chronic pressure overload (PO)...
  39. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2013
    ..Arterial thrombosis and the acute ischemic events that follow, such as myocardial infarction and stroke, are among the leading causes of death, incapacitation, and rising health care costs in the ..
  40. The role of the orphan receptor tyrosine kinase Ros1 in vascular disease
    ZIAD ANWAR ALI; Fiscal Year: 2011
    ..Allelic variation in ROS1 has been implicated in myocardial infarction, ischemic stroke, in-stent stenosis and hypertension...
  41. Prolylcarboxypeptidase is a Risk Factor for Cardiovascular Disease
    Alvin H Schmaier; Fiscal Year: 2013
    ..The goal of this proposal is to determine if PRCP is a risk factor for hypertension and/or myocardial infarction (MI)/stroke with and without adjustment for body type, i.e. body mass index...
  42. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..We demonstrated that the incidence of myocardial infarction (MI) remained stable over time while trends diverged by age and sex with an increase in women and the ..
  43. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..there is a significant need for innovative oxygen delivery approaches to treat such conditions as stroke, myocardial infarction, coronary blockage, organ preservation for transplantation, and malignant disease which affect more than 4 ..
  44. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..of MI-R injury and provide the foundation for the development of H2S therapy for the treatment of acute myocardial infarction. PUBLIC HEALTH RELEVANCE: Despite numerous advances in health care, cardiovascular disease remains the ..
  45. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..therapy with aspirin, clopidogrel, or their combination, is currently standard of care for prevention of myocardial infarction (MI), stroke, and following percutaneous coronary intervention...
  46. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2012
    Air pollution is positively associated with an increased daily incidence of myocardial infarction and cardiovascular mortality...
  47. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2012
    ..By 2010, more than 600 cases of myocardial infarction will have been confirmed by medical record review among women in the fasting blood cohort...
  48. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..genes and their relationships to diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, myocardial infarction, stroke, and cognitive dysfunction outcomes...
  49. Cardiomyocyte Zinc and its Regulation of Contraction-Relaxation Function
    Bradley M Palmer; Fiscal Year: 2012
    ..function and occurs frequently in conditions (such as diabetes, hypertension coronary artery disease or myocardial infarction) that lead to related cardiomyopathies or heart failure...
  50. Impact of Cardiovascular and Weight Loss diets on Uric Acid and Gout Risk
    Hyon K Choi; Fiscal Year: 2013
    ..hypertension in 74% and obesity in 53% of cases) and their consequences (e.g., increased future risk of myocardial infarction and premature death)...
  51. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..Thrombus is implicated in a range of pathologies, e.g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis...
  52. MECHANISMS OF MALADAPTATION IN HEART FAILURE
    Howard A Rockman; Fiscal Year: 2013
    ..In contrast, activation of b1AR appears to exert a primarily adverse influence on post myocardial infarction (MI) cardiac remodeling...
  53. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    ..is the accumulation of cholesterol in arteries, resulting in plaque which can lead to a heart attack (myocardial infarction (MI))...
  54. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..b) Women with endometriosis are at greater risk of hypertension, hypercholesterolemia, type 2 diabetes, myocardial infarction, and ischemic stroke...
  55. Cardioprotective Signaling following Phosphodiesterase-5 Inhibition
    Rakesh C Kukreja; Fiscal Year: 2012
    Project Description Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. Nearly 200,000 patients die yearly of AMI in the US alone...
  56. Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis Postinfarction
    Yao Sun; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myocardial infarction (MI) has emerged as a major health problem during the past two decades. In the infarcted myocardium, loss of contractile myocardium and blood vessels is induced by MI...
  57. Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds
    Paul H Goldspink; Fiscal Year: 2013
    ..Aim 3 determines the cellular, molecular and functional gains that occur at different stages following myocardial infarction after MRS delivery of GFs to the border zone of an infarct...
  58. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2012
    ..The most common event is a myocardial infarction in the heart and this is the leading cause of death in the U.S...
  59. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    ..Research Design and Methods: In a rat model of myocardial infarction and ventricular remodeling, bone marrow production of EPCs will be stimulated with granulocyte macrophage ..
  60. Genetic and Cellular Basis of Resistance/Sensitivity to Myocardial Ischemia
    Howard J Jacob; Fiscal Year: 2012
    b>Myocardial infarction (MI) is a major health problem in the United States. The polygenic nature of the resistance and/or sensitivity of the heart to ischemia are well accepted...
  61. Association of a common variant of the PPAP2B gene with cardiovascular disease.
    Andrew J Morris; Fiscal Year: 2013
    ..gene expression could aggravate cellular events underlying atherosclerosis and increase the likelihood of myocardial infarction. The broad long-term goal of this research project is to explain how human genetic variation at the PPAP2B ..
  62. Structure-Based Design of Novel HNF4a Antagonists to Treat Metabolic Syndrome
    Arnold T Hagler; Fiscal Year: 2010
    ..and significantly increasing the risk of coronary heart disease (CHD), atherosclerosis, diabetes, myocardial infarction, stroke and even death in those afflicted...
  63. Histone Deacetylase Inhibition: A Novel Approach to Cardioprotection
    Ting C Zhao; Fiscal Year: 2012
    b>Myocardial infarction contributes a major reason for cardiovascular disease despite the multiple significant therapeutic advances. Myocardial ischemia/reperfusion injury is still a major unsolved problem...
  64. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John K Buolamwini; Fiscal Year: 2010
    ..explore the cardioprotective effects of ENT4 inhibitors in an isolated rat heart global ischemia model of myocardial infarction. The new ENT4 inhibitors will be compared with our recently discovered cardioprotective ENT1 inhibitors (..
  65. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Project Summary/Abstract Myocardial infarction and resulting congestive heart failure remain the number one cause of mortality in the United States and affect the aging veteran population ..
  66. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..has further been recognized as an independent risk factor for future cardiovascular events, in particular myocardial infarction and stroke...
  67. CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTES
    RICHARD HONKANEN; Fiscal Year: 2002
    ..Further study of the effects of this PP inhibitor may lead to greater insight concerning downstream effectors of preconditioning. ..
  68. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    ..by applicant): Ischemia-reperfusion injury (IRI) is a major problem in many clinical scenarios, including myocardial infarction and stroke...
  69. Mannose binding lectin and outcomes following CABG
    GREGORY L contact STAHL; Fiscal Year: 2010
    Coronary vascular disease can lead to myocardial infarction. While increased standards of care have greatly improved morbidity and mortality following infarction, it is now widely accepted that ischemia/reperfusion (I/R) injury occurs ..
  70. CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
    WILLIAM SANTAMORE; Fiscal Year: 1990
    ..have generated renewed interest that vasomotion might be involved in the etiology of angina pectoris and myocardial infarction. At the same time, post myocardial infarction thrombolytic therapy has proven to be very successful: a ..
  71. Prevention of ischemia reperfusion injury associated with acute myocardial infarc
    Craig Sherman; Fiscal Year: 2010
    ..Studies in animal models of acute myocardial infarction suggest that lethal ischemia-reperfusion injury can account for approximately 50% of the final size of a ..
  72. Nurses' Health Study: Short Sleep Duration and Risk of Hypertension
    JAMES GANGWISCH; Fiscal Year: 2009
    ..Daytime sleepiness has been shown to be associated with increased risk for stroke and myocardial infarction, but previous studies were not able to control for snoring which is highly emblematic of sleep apnea...
  73. Development of an In Vivo Stem Cell Tracking Method Using Ultrasound Imaging
    Flordeliza S Villanueva; Fiscal Year: 2010
    ..Congestive heart failure resulting from myocardial infarction and subsequent adverse left ventricular remodeling is a major cause of morbidity, mortality and health ..
  74. DEVELOPING CELLULAR CARDIOMYOPLASTY FOR INJURED HEART
    DORIS TAYLOR; Fiscal Year: 2001
    ..regenerate or repair itself, the end result of ischemic heart disease (IHD) is often progression of acute myocardial infarction (AMI) to congestive heart failure (CHF) resulting in the death of over 41,000 persons annually...
  75. Transfusion Trigger Trial in Coronary Artery Disease: A Pilot Study
    JEFFREY LEE CARSON; Fiscal Year: 2010
    ..clinical trial in 200 patients age 18 or older admitted to the hospital with 1) STEMI (ST segment elevated myocardial infarction), 2) NSTEMI (Non ST segment elevation myocardial infarction), 3) unstable angina, or 4) stable coronary ..
  76. SURGERY FOR ACUTE MYOCARDIAL INFARCTION
    L Edmunds; Fiscal Year: 2000
    ..applicant's abstract) The rationale for this proposal is that the size, transmurality and location of a myocardial infarction, the material properties of the healing infarct and the continued stimulation of the renin-angiotensin-..
  77. Cord Blood: Treatment for Acute Myocardial Infarction
    William Marshall; Fiscal Year: 2005
    ..is required; and in order to move this therapy into human clinical trials for the treatment of myocardial infarction and prevention of congestive heart failure which affects over 5 million patients in the U.S...
  78. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    ..in a healthy population to be used as cutoff levels for the sensitive and specific detection of acute myocardial infarction (AMI), supporting the replacement of creatine kinase MB (CKMB) as the new standard biochemical marker for ..
  79. Bone Marrow Angioblasts for Myocardial Vasculogenesis
    Silviu Itescu; Fiscal Year: 2006
    ..remains a major public health problem, and is frequently the result of left ventricular remodeling after myocardial infarction. We have recently shown that human adult bone marrow contains endothelial progenitors with phenotypic and ..
  80. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..verbatim): Older age is associated with a marked increase in cardiac morbidity and mortality following a myocardial infarction regardless of the administration of thrombolytic therapy, an early invasive approach, and the use of ..
  81. INTEGRATIVE APPROACH TO CORONARY THROMBOSIS
    Robert Montgomery; Fiscal Year: 2001
    ..The clinical syndromes of stable and unstable angina, myocardial infarction and reocclusion of a coronary artery following thrombolytic therapy, form a spectrum of thrombotic related ..
  82. Race and cardiac catheterization use in the setting of acute myocardial infarctio
    Saif Rathore; Fiscal Year: 2009
    ..and validate a means for classifying patients'appropriateness of cardiac catheterization following myocardial infarction using data from the CCP, a national cohort of Medicare patients hospitalized for myocardial infarction ..