coronary stenosis

Summary

Summary: Narrowing or constriction of a coronary artery.

Top Publications

  1. ncbi A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease
    Gregg W Stone
    Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York 10022, USA
    N Engl J Med 350:221-31. 2004
  2. ncbi Functional measurement of coronary stenosis
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 59:1045-57. 2012
  3. ncbi Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coro
    Matthew J Budoff
    Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California, USA
    J Am Coll Cardiol 52:1724-32. 2008
  4. ncbi Noninvasive coronary angiography by 320-row computed tomography with lower radiation exposure and maintained diagnostic accuracy: comparison of results with cardiac catheterization in a head-to-head pilot investigation
    Marc Dewey
    Charite, Medical School, Departments of Radiology, Humboldt Universitat zu Berlin, Freie Universitat Berlin, Berlin, Germany
    Circulation 120:867-75. 2009
  5. ncbi Comprehensive assessment of coronary artery stenoses: computed tomography coronary angiography versus conventional coronary angiography and correlation with fractional flow reserve in patients with stable angina
    W Bob Meijboom
    Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 52:636-43. 2008
  6. ncbi Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study
    Nico H J Pijls
    Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 49:2105-11. 2007
  7. ncbi Diagnostic and prognostic value of absence of coronary artery calcification
    Ammar Sarwar
    Cardiac PET CT MRI Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    JACC Cardiovasc Imaging 2:675-88. 2009
  8. ncbi Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial
    David E Kandzari
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 48:2440-7. 2006
  9. ncbi Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction
    Argyrios Ntalianis
    Cardiovascular Center, Aalst, OLV Clinic, Moorselbaan 164, Aalst, Belgium
    JACC Cardiovasc Interv 3:1274-81. 2010
  10. ncbi Influence of heart rate on the diagnostic accuracy of dual-source computed tomography coronary angiography
    Ulrike Ropers
    Department of Internal Medicine 2 Cardiology Angiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Coll Cardiol 50:2393-8. 2007

Detail Information

Publications278 found, 100 shown here

  1. ncbi A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease
    Gregg W Stone
    Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York 10022, USA
    N Engl J Med 350:221-31. 2004
    ..Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The delivery of paclitaxel to the site of vascular injury may reduce the incidence of neointimal hyperplasia and restenosis...
  2. ncbi Functional measurement of coronary stenosis
    Nico H J Pijls
    Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 59:1045-57. 2012
    ..In this state-of-the-art paper, the basic concept of FFR and its application, characteristics, and use in several subsets of patients are discussed from a practical point of view...
  3. ncbi Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coro
    Matthew J Budoff
    Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California, USA
    J Am Coll Cardiol 52:1724-32. 2008
    ..The purpose of this study was to evaluate the diagnostic accuracy of electrocardiographically gated 64-multidetector row coronary computed tomographic angiography (CCTA) in individuals without known coronary artery disease (CAD)...
  4. ncbi Noninvasive coronary angiography by 320-row computed tomography with lower radiation exposure and maintained diagnostic accuracy: comparison of results with cardiac catheterization in a head-to-head pilot investigation
    Marc Dewey
    Charite, Medical School, Departments of Radiology, Humboldt Universitat zu Berlin, Freie Universitat Berlin, Berlin, Germany
    Circulation 120:867-75. 2009
    ..We evaluated coronary angiography using whole-heart 320-row CT, which avoids exposure-intensive overscanning and overranging...
  5. ncbi Comprehensive assessment of coronary artery stenoses: computed tomography coronary angiography versus conventional coronary angiography and correlation with fractional flow reserve in patients with stable angina
    W Bob Meijboom
    Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 52:636-43. 2008
    ..coronary angiography [CTCA]) and quantitative computed tomography coronary angiography (QCT) to predict the hemodynamic significance of a coronary stenosis, using intracoronary fractional flow reserve (FFR) as the reference standard.
  6. ncbi Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study
    Nico H J Pijls
    Catharina Hospital Eindhoven, Eindhoven, The Netherlands
    J Am Coll Cardiol 49:2105-11. 2007
    ..The purpose of this study was to investigate the appropriateness of stenting a functionally nonsignificant stenosis...
  7. ncbi Diagnostic and prognostic value of absence of coronary artery calcification
    Ammar Sarwar
    Cardiac PET CT MRI Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    JACC Cardiovasc Imaging 2:675-88. 2009
    ..In this study, we systematically assessed the diagnostic and prognostic value of absence of coronary artery calcification (CAC) in asymptomatic and symptomatic individuals...
  8. ncbi Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial
    David E Kandzari
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 48:2440-7. 2006
    ..This trial examined the relative clinical efficacy, angiographic outcomes, and safety of zotarolimus-eluting coronary stents (ZES) with a phosphorylcholine polymer versus sirolimus-eluting stents (SES)...
  9. ncbi Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction
    Argyrios Ntalianis
    Cardiovascular Center, Aalst, OLV Clinic, Moorselbaan 164, Aalst, Belgium
    JACC Cardiovasc Interv 3:1274-81. 2010
    ..We investigated the reliability of fractional flow reserve (FFR) of nonculprit coronary stenoses during percutaneous coronary intervention (PCI) in acute myocardial infarction...
  10. ncbi Influence of heart rate on the diagnostic accuracy of dual-source computed tomography coronary angiography
    Ulrike Ropers
    Department of Internal Medicine 2 Cardiology Angiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Coll Cardiol 50:2393-8. 2007
    ..We evaluated the influence of heart rate on image quality and diagnostic accuracy of dual-source computed tomography (DSCT) coronary angiography...
  11. ncbi Computational fluid dynamics applied to cardiac computed tomography for noninvasive quantification of fractional flow reserve: scientific basis
    Charles A Taylor
    HeartFlow, Inc, Redwood City, California, USA
    J Am Coll Cardiol 61:2233-41. 2013
    ..Given the significant interest in this novel method for determining the physiological significance of coronary artery disease, we herein present a review on the scientific principles that underlie this technology...
  12. ncbi Acute and long-term outcomes of the novel side access (SLK-View) stent for bifurcation coronary lesions: a multicenter nonrandomized feasibility study
    Fumiaki Ikeno
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94304, USA
    Catheter Cardiovasc Interv 67:198-206. 2006
    ..To evaluate technical feasibility and procedural safety of SLK-View stent for treating bifurcation lesions...
  13. ncbi The Frontier stent registry: safety and feasibility of a novel dedicated stent for the treatment of bifurcation coronary artery lesions
    Thierry Lefevre
    Institut Hospitalier Jacques Cartier, Massy, France
    J Am Coll Cardiol 46:592-8. 2005
    ..Santa Clara, California), a novel dedicated device designed for permanent side branch (SB) access, stent delivery by simultaneous kissing balloon inflation, and optimal main branch (MB) and SB ostium scaffolding...
  14. ncbi Randomized comparison of 64-slice single- and dual-source computed tomography coronary angiography for the detection of coronary artery disease
    Stephan Achenbach
    Department of Cardiology, University of Erlangen, Germany
    JACC Cardiovasc Imaging 1:177-86. 2008
    ..The purpose of this study was to analyze the influence of a systematic approach to lower heart rate for coronary computed tomography (CT) angiography on diagnostic accuracy of 64-slice single- and dual-source CT...
  15. ncbi Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    B G Brown
    Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
    N Engl J Med 345:1583-92. 2001
    ..The end points were arteriographic evidence of a change in coronary stenosis and the occurrence of a first cardiovascular event (death, myocardial infarction, stroke, or ..
  16. ncbi Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease
    Fleur R de Graaf
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Eur Heart J 31:1908-15. 2010
    ..The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD...
  17. ncbi Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation
    Pim A L Tonino
    Department of Cardiology, Catharina Hospital, Michelangelolaan 2, Eindhoven 5623 EJ, The Netherlands
    J Am Coll Cardiol 55:2816-21. 2010
    ..The purpose of this study was to investigate the relationship between angiographic and functional severity of coronary artery stenoses in the FAME (Fractional Flow Reserve Versus Angiography in Multivessel Evaluation) study...
  18. ncbi Paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction
    Gregg W Stone
    Columbia University Medical Center and New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10022, USA
    N Engl J Med 360:1946-59. 2009
    ....
  19. ncbi Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions
    Antonio Colombo
    EMO Centro Cuore Columbus, Milan, Italy
    Circulation 109:1244-9. 2004
    ..A sirolimus-eluting stent (Cypher, Cordis Corp) has been reported to markedly decrease restenosis in selected lesions; higher-risk lesions, including coronary bifurcations, have not been studied...
  20. ncbi Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drug-eluting versus bare-metal stents
    Matthias Pfisterer
    Department of Cardiology, University Hospital, Basel, Switzerland
    J Am Coll Cardiol 48:2584-91. 2006
    ..We sought to define the incidence of late clinical events and late stent thrombosis in patients treated with drug-eluting (DES) versus bare-metal stents (BMS) after the discontinuation of clopidogrel as well as their timing and outcome...
  21. ncbi Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease
    Alexandre Berger
    Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium
    J Am Coll Cardiol 46:438-42. 2005
    ....
  22. ncbi Impact of intravascular ultrasound guidance on long-term clinical outcomes in patients treated with drug-eluting stent for bifurcation lesions: data from a Korean multicenter bifurcation registry
    Jung Sun Kim
    Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea
    Am Heart J 161:180-7. 2011
    ..The aim of this study was to investigate the impact of IVUS guidance on long-term clinical outcomes during drug-eluting stent (DES) implantation for bifurcation lesions...
  23. ncbi A challenging case of dislodged stent retrieval with the use of Goose neck snare kit
    Chao Yang Soon
    Division of Cardiology, Alexandra Hospital, Singapore, Singapore
    Catheter Cardiovasc Interv 75:630-3. 2010
    ..The patient recovered well and was discharged the following day...
  24. ncbi Final kissing ballooning and long-term clinical outcomes in coronary bifurcation lesions treated with 1-stent technique: results from the COBIS registry
    Hyeon Cheol Gwon
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Heart 98:225-31. 2012
    ..Whether final kissing ballooning (FKB) is mandatory in the 1-stent technique is uncertain...
  25. ncbi The impact of patient and lesion complexity on clinical and angiographic outcomes after revascularization with zotarolimus- and everolimus-eluting stents: a substudy of the RESOLUTE All Comers Trial (a randomized comparison of a zotarolimus-eluting stent
    Giulio G Stefanini
    Bern University Hospital, Bern, Switzerland
    J Am Coll Cardiol 57:2221-32. 2011
    ..The aim of this study was to investigate the impact of patient and lesion complexity on outcomes with newer-generation zotarolimus-eluting stents (ZES) and everolimus-eluting stents (EES)...
  26. pmc Relationship of epicardial fat volume to coronary plaque, severe coronary stenosis, and high-risk coronary plaque features assessed by coronary CT angiography
    Ronak Rajani
    Department of Imaging, Cedars Sinai Medical Center, Cedars Sinai Heart Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Cardiovasc Comput Tomogr 7:125-32. 2013
    ..Associations of epicardial fat volume (EFV) measured on noncontrast cardiac CT (NCT) include coronary plaque, myocardial ischemia, and adverse cardiac events...
  27. ncbi The impact of pravastatin pre-treatment on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention
    Kenichi Fujii
    Cardiovascular Division, Hyogo College of Medicine, Nishinomiya, Japan
    JACC Cardiovasc Interv 4:513-20. 2011
    ..This study evaluated the effect of pravastatin pre-treatment on post-procedural index of microcirculatory resistance (IMR) values that are introduced for assessing the status of the microcirculation independently of the epicardial area...
  28. pmc Fibroblast growth factor 23 and fetuin A are independent predictors for the coronary artery disease extent in mild chronic kidney disease
    Mehmet Kanbay
    Department of Internal Medicine, Section of Nephrology, Fatih University School of Medicine, Ankara, Turkey
    Clin J Am Soc Nephrol 5:1780-6. 2010
    ....
  29. ncbi Resting Pd/Pa measured with intracoronary pressure wire strongly predicts fractional flow reserve
    Mamas A Mamas
    Manchester Heart Centre, Manchester Royal Infirmary, Biomedical Research Centre, Manchester, United Kingdom
    J Invasive Cardiol 22:260-5. 2010
    ..To investigate the relationship between resting distal coronary pressure to aortic pressure ratio (Pd/Pa) and fractional flow reserve (FFR) obtained during maximal hyperemia...
  30. ncbi Assessment of coronary stenosis by a 16-slice MDCT scanner in asymptomatic diabetic patients starting dialysis therapy
    Kenichiro Iio
    Department of Nephrology, Izumisano Municipal Hospital, Rinku General Medical Center, Izumisano, Japan
    Nephron Clin Pract 109:c72-9. 2008
    The accuracy for the detection of coronary stenosis by multidetector row computed tomography (MDCT) has been getting more recognition. However, the usefulness of MDCT in patients with chronic kidney disease (CKD) has not been confirmed.
  31. ncbi Usefulness of noninvasive fractional flow reserve computed from coronary computed tomographic angiograms for intermediate stenoses confirmed by quantitative coronary angiography
    James K Min
    Cedars Sinai Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Cardiol 110:971-6. 2012
    ..03 ± 0.12, p = 0.054). In conclusion, FFR(CT) is a novel noninvasive method for diagnosis of lesion-specific ischemia of coronary lesions of intermediate stenosis severity...
  32. ncbi First-pass myocardial perfusion cardiovascular magnetic resonance at 3 Tesla
    Mao Yuan M Su
    Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan
    J Cardiovasc Magn Reson 9:633-44. 2007
    ....
  33. ncbi Morphometric assessment of coronary stenosis relevance with optical coherence tomography: a comparison with fractional flow reserve and intravascular ultrasound
    Nieves Gonzalo
    Department of Interventional Cardiology, Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain
    J Am Coll Cardiol 59:1080-9. 2012
    ..Concomitant OCT and intravascular ultrasound (IVUS) area measurements were performed in a subgroup of patients to compare the diagnostic efficiency of both techniques...
  34. ncbi Noninvasive detection of coronary artery stenoses with multislice computed tomography or magnetic resonance imaging
    Marc Dewey
    Department of Radiology, Charite Medical School, Humboldt Universitat, Berlin, Germany
    Ann Intern Med 145:407-15. 2006
    ....
  35. pmc Epicardial adipose tissue thickness is an indicator for coronary artery stenosis in asymptomatic type 2 diabetic patients: its assessment by cardiac magnetic resonance
    Hyun Min Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Cardiovasc Diabetol 11:83. 2012
    ..We used cardiovascular magnetic resonance (CMR) to investigate the association between epicardial adipose tissue (EAT) thickness and silent myocardial ischemia, as well as coronary artery stenosis, in asymptomatic type 2 diabetic patients...
  36. ncbi Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure-Only Ratios Against Indices Using Flow Study
    Sayan Sen
    International Centre for Circulatory Health, National Heart and Lung Institute, London, United Kingdom
    J Am Coll Cardiol 61:1409-20. 2013
    ..This study sought to determine if adenosine administration is required for the pressure-only assessment of coronary stenoses...
  37. ncbi Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population
    Lamia Rebhi
    Biochemistry Department, Sahloul University Hospital, 4054 Sousse, Tunisia
    Mol Biol Rep 39:9893-901. 2012
    ..Our aim was to study the association between six polymorphisms, haplotypes and significant coronary stenosis (SCS), disease severity and lipid parameters in Tunisian patients...
  38. ncbi Angiographic surrogate end points in drug-eluting stent trials: a systematic evaluation based on individual patient data from 11 randomized, controlled trials
    Stuart J Pocock
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Am Coll Cardiol 51:23-32. 2008
    ..We sought to validate 4 angiographic measures as potential surrogates for clinical restenosis (target lesion revascularization [TLR]) after stent implantation...
  39. ncbi VERIFY (VERification of Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis Severity in EverydaY Practice): a multicenter study in consecutive patients
    Colin Berry
    BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
    J Am Coll Cardiol 61:1421-7. 2013
    ..This study sought to compare fractional flow reserve (FFR) with the instantaneous wave-free ratio (iFR) in patients with coronary artery disease and also to determine whether the iFR is independent of hyperemia...
  40. ncbi The human coronary collateral circulation
    Christian Seiler
    Cardiology, University Hospital, Bern, Switzerland
    Eur J Clin Invest 40:465-76. 2010
    ..Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) mitigate myocardial infarcts and improve survival...
  41. ncbi Four polymorphisms of cholesteryl ester transfer protein gene and coronary stenosis in a Tunisian population
    Jihene Rejeb
    Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia
    J Cardiovasc Med (Hagerstown) 13:546-53. 2012
    ..We studied the association of four polymorphisms (Taq1B, I405V, R451Q and A373P) in the CETP gene with lipid profile and coronary artery disease...
  42. ncbi Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention
    Michael C H Leung
    Cardiovascular Research Centre, Monash Medical Centre and Monash Univ, Melbourne, Victoria, Australia
    Am J Physiol Heart Circ Physiol 290:H624-30. 2006
    ..In 18 subjects undergoing elective PCI, a Doppler velocity guidewire was positioned proximal to a severe coronary stenosis to measure resting and adenosine-induced hyperemic CBF before and after PCI...
  43. ncbi Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease
    Bin Wang
    Department of Pharmacology, Institute of Clinical Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Najing, 210029 Jiangsu Province, China
    Atherosclerosis 184:425-30. 2006
    ..001) and the extent score of coronary stenosis (P<0.001)...
  44. ncbi Comparison of effects of rosuvastatin and atorvastatin on plaque regression in Korean patients with untreated intermediate coronary stenosis
    Young Joon Hong
    Heart Center of Chonnam National University Hospital, Gwangju, Korea
    Circ J 75:398-406. 2011
    Serial intravascular ultrasound (IVUS) was used to compare the effects of moderate doses of rosuvastatin and atorvastatin on plaque regression in patients with intermediate coronary stenosis.
  45. ncbi Quantification of coronary arterial stenoses by multidetector CT angiography in comparison with conventional angiography methods, caveats, and implications
    Armin Arbab-Zadeh
    Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
    JACC Cardiovasc Imaging 4:191-202. 2011
    ..and composition in addition to lumen obstruction shows strong promise for improved risk assessment and may at last enable us to move beyond mere coronary stenosis assessment for the management of patients with coronary artery disease.
  46. ncbi Dual-source CT angiography for detection and quantification of in-stent restenosis in the left main coronary artery: comparison with intracoronary ultrasound and coronary angiography
    Josef Veselka
    Department of Cardiology, Cardiovascular Center, University Hospital Motol, Vuvalu 84, Prague 5, 15000, Czech Republic
    J Invasive Cardiol 23:460-4. 2011
    ....
  47. ncbi Physiologic assessment of jailed side branch lesions using fractional flow reserve
    Bon Kwon Koo
    Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center and Cardiovascular Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    J Am Coll Cardiol 46:633-7. 2005
    ....
  48. ncbi Coronary CT angiography and myocardial perfusion imaging to detect flow-limiting stenoses: a potential gatekeeper for coronary revascularization?
    Oliver Gaemperli
    Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Eur Heart J 30:2921-9. 2009
    ....
  49. pmc 64-Slice CT coronary angiography in patients with non-ST elevation acute coronary syndrome
    Willem B Meijboom
    Department of Cardiology, Thoraxcenter, and Radiology, Rotterdam, The Netherlands
    Heart 93:1386-92. 2007
    ....
  50. ncbi Incidence and predictors of drug-eluting stent fracture in human coronary artery a pathologic analysis
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, Maryland, USA
    J Am Coll Cardiol 54:1924-31. 2009
    ..The aim of this study was to perform pathologic assessment on stent fracture...
  51. ncbi The incidence and clinical impact of stent strut fractures developed after drug-eluting stent implantation
    Wook Sung Chung
    Catholic University Saint Mary s Hospital, Youeuido dong, Youngdeungpo gu, Seoul, 150 713 Korea
    Int J Cardiol 125:325-31. 2008
    ..Then we sought to define the incidence and clinical implications of SSFs developed after drug-eluting stent (DES) implantation...
  52. ncbi Assessment of intermediate severity coronary lesions in the catheterization laboratory
    Jonathan Tobis
    David Geffen School of Medicine at UCLA, Department of Medicine, Division of Cardiology, Los Angeles, California 90095 1717, USA
    J Am Coll Cardiol 49:839-48. 2007
    ..In addition, the importance of IVUS and FFR in the management of patients with serial stenosis, bifurcation lesions, left main disease, saphenous vein graft disease, and acute coronary syndrome will be discussed...
  53. ncbi Functional and structural adaptations of coronary microvessels distal to a chronic coronary artery stenosis
    Oana Sorop
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circ Res 102:795-803. 2008
    ..These structural and functional alterations may aggravate flow abnormalities distal to a chronic coronary artery stenosis...
  54. ncbi Diagnostic accuracy of dual-source computed tomography in the diagnosis of coronary artery disease
    Thorsten R C Johnson
    Department Clinical Radiology, Medical Clinic I, University of Munich, Grosshadern Campus, Munich, Germany
    Invest Radiol 42:684-91. 2007
    ....
  55. ncbi Potential and limitations of wave intensity analysis in coronary arteries
    Maria Siebes
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Med Biol Eng Comput 47:233-9. 2009
    ..In conclusion, although SPc lacks accuracy in determining local coronary wave speed it is within limits still applicable for wave separation in coronary WIA...
  56. ncbi Comparison of percutaneous versus surgical revascularization of severe unprotected left main coronary stenosis in matched patients
    Sorin J Brener
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 101:169-72. 2008
    ..Diabetes mellitus and advanced co-morbidity were the principal determinants of survival. These findings support the need for randomized trials with adequate follow-up to compare the 2 approaches...
  57. pmc Randomized trial on routine vs. provisional T-stenting in the treatment of de novo coronary bifurcation lesions
    Miroslaw Ferenc
    Herz Zentrum Bad Krozingen, Suedring 15, 79189 Bad Krozingen, Germany
    Eur Heart J 29:2859-67. 2008
    ..We investigated whether routine T-stenting reduces restenosis of the side branch as compared with provisional T-stenting in patients with de novo coronary bifurcation lesions...
  58. ncbi Culprit vessel only versus multivessel and staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-segment elevation myocardial infarction: a pairwise and network meta-analysis
    Pieter J Vlaar
    Department of Cardiology, Thorax Center, University Medical Center Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 58:692-703. 2011
    ....
  59. ncbi Stent deployment failure: reasons, implications, and short- and long-term outcomes
    Evgenia Nikolsky
    Division of Invasive Cardiology, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Catheter Cardiovasc Interv 59:324-8. 2003
    ..3%, mainly due to failure to deliver the stent to the site. Another stent was successfully deployed in the majority of cases and these patients had favorable short- and long-term outcomes...
  60. ncbi Impact of intravascular ultrasound guidance on long-term mortality in stenting for unprotected left main coronary artery stenosis
    Seung Jung Park
    Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Circ Cardiovasc Interv 2:167-77. 2009
    ..Although intravascular ultrasound (IVUS) guidance has been useful in stenting for unprotected left main coronary artery stenosis, its impact on long-term mortality is still unclear...
  61. ncbi Cardiac magnetic resonance perfusion imaging for the functional assessment of coronary artery disease: a comparison with coronary angiography and fractional flow reserve
    Johannes Rieber
    Department of Cardiology, Division of Internal Medicine, University of Munich Germany
    Eur Heart J 27:1465-71. 2006
    ..To prospectively assess the diagnostic value of CMRI for the detection of haemodynamically significant coronary lesions, compared with coronary angiography (CA) and FFR...
  62. ncbi Sirolimus-eluting stent implantation aggravates endothelial vasomotor dysfunction in the infarct-related coronary artery in patients with acute myocardial infarction
    Jyun Ei Obata
    Department of Internal Medicine II, University of Yamanashi, Yamanashi Prefecture, Japan
    J Am Coll Cardiol 50:1305-9. 2007
    ..This study examined whether sirolimus-eluting stent (SES) implantation may affect endothelial vasomotor dysfunction in resistance and epicardial infarct-related coronary arteries in acute myocardial infarction (AMI)...
  63. ncbi Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, University of California, San Diego, La Jolla, CA 92093 0682, USA
    N Engl J Med 353:46-57. 2005
    ....
  64. ncbi Coronary collateral flow in response to endurance exercise training
    Rainer Zbinden
    Department of Cardiology, University Hospital, Bern, Switzerland
    Eur J Cardiovasc Prev Rehabil 14:250-7. 2007
    ....
  65. ncbi Decreased number of circulating plasmacytoid dendritic cells in patients with atherosclerotic coronary artery disease
    Emily A Van Vré
    Division of Cardiology, University of Antwerp, Wilrijk, Belgium
    Coron Artery Dis 17:243-8. 2006
    ..The relation with the extent of coronary artery disease, the clinical syndrome and with a marker of inflammation will be documented...
  66. ncbi Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis
    Demosthenes G Katritsis
    Department of Cardiology, Athens Euroclinic, Athens, Greece
    Circulation 111:2906-12. 2005
    ..Therefore, we performed a meta-analysis of 11 randomized trials comparing PCI to conservative treatment in patients with stable CAD...
  67. ncbi Reliable high-speed coronary computed tomography in symptomatic patients
    Annick C Weustink
    Department of Cardiology, Thoraxcenter, Rotterdam, The Netherlands
    J Am Coll Cardiol 50:786-94. 2007
    ....
  68. ncbi Comparison of efficacy and safety of lower-dose to higher-dose oral prednisone after percutaneous coronary interventions (the IMPRESS-LD study)
    Valeria Ferrero
    Division of Cardiology, Universita di Verona, Italy
    Am J Cardiol 99:1082-6. 2007
    ..A 50% dose decrease in oral prednisone, as tested in this study, is less effective than the previously tested HD IMPRESS therapeutic scheme...
  69. ncbi Image quality in a low radiation exposure protocol for retrospectively ECG-gated coronary CT angiography
    Tobias Pflederer
    Department of Internal Medicine 2 Cardiology, University of Erlangen, Ulmenweg 18, D 91054 Erlangen, Germany
    AJR Am J Roentgenol 192:1045-50. 2009
    ..The purpose of our study was to systematically compare the image quality of dual-source CT coronary angiography using 100 kV instead of 120 kV...
  70. ncbi Prognostic value of coronary computed tomographic angiography for prediction of cardiac events in patients with suspected coronary artery disease
    Martin Hadamitzky
    Klinik für Herz und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Munich, Germany
    JACC Cardiovasc Imaging 2:404-11. 2009
    ..We assessed the rate of cardiac events after detection or exclusion of obstructive coronary artery disease (CAD) by coronary computed tomography angiography (CCTA)...
  71. ncbi Diagnostic performance of magnetic resonance first pass perfusion imaging is equally potent in female compared to male patients with coronary artery disease
    Nico Merkle
    Clinic of Internal Medicine II Cardiology, University Hospital of Ulm, Albert Einstein Allee 23, 89081, Ulm, Germany
    Clin Res Cardiol 99:21-8. 2010
    ..Therefore, we tested the diagnostic power of cardiac magnetic resonance first pass perfusion imaging (CMR-FPPI) for the diagnosis of significant coronary stenoses in females versus males...
  72. ncbi Update on dedicated bifurcation stents
    Imad Sheiban
    From the Interventional Cardiology, Division of Cardiology, University of Turin, Turin, Italy
    J Interv Cardiol 22:150-5. 2009
    ..The development of further drug-eluting platforms and larger controlled studies should demonstrate their clinical applicability, efficacy, and safety before they are widely incorporated into daily practice...
  73. ncbi Effectiveness of dual-source CT coronary angiography for the evaluation of coronary artery disease in patients with atrial fibrillation: initial experience
    Dilek Oncel
    Department of Radiology, Sifa Medical Center, Fevzipasa Boulevard No 172 2, 35340 Basmane Izmir, Turkey
    Radiology 245:703-11. 2007
    To prospectively evaluate the sensitivity and specificity of dual-source CT for significant coronary stenosis (>50% narrowing) in patients with atrial fibrillation (AF), by using conventional coronary angiography as the reference ..
  74. ncbi Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention
    Jason B Lindsey
    Division of Cardiovascular Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Cardiovasc Revasc Med 9:47-51. 2008
    ..Extrinsic compression of the LMCA should be considered in patients with severe PH and angina; IVUS may aid in the diagnosis. Percutaneous stent implantation may be the preferred treatment in this high-risk group of patients...
  75. ncbi Evaluation of the haemodynamic characteristics of drug-eluting stents at implantation and at follow-up
    Marcel van't Veer
    Department of Cardiology, Catharina Hospital, PO Box 1350, 5602 ZA Eindhoven, The Netherlands
    Eur Heart J 27:1811-7. 2006
    ....
  76. ncbi Does the instantaneous wave-free ratio approximate the fractional flow reserve?
    Nils P Johnson
    Weatherhead PET Center for Preventing and Reversing Atherosclerosis, Division of Cardiology, Department of Medicine, University of Texas Medical School and Memorial Hermann Hospital, Houston, Texas
    J Am Coll Cardiol 61:1428-35. 2013
    ..This study sought to examine the clinical performance of and theoretical basis for the instantaneous wave-free ratio (iFR) approximation to the fractional flow reserve (FFR)...
  77. ncbi Non-invasive assessment of plaque rupture by 64-slice multidetector computed tomography--comparison with intravascular ultrasound
    Atsushi Tanaka
    Wakayama Medical University, Department of Cardiovascular Medicine, Wakayama, Japan
    Circ J 72:1276-81. 2008
    ..In this study, we investigated whether 64-slice MDCT could non-invasively detect a plaque rupture in patients with de novo angina...
  78. ncbi Comparison of 64-slice multi-detector computed tomography coronary angiography between asymptomatic, type 2 diabetes mellitus and impaired glucose tolerance patients
    Shigenori Sassa
    Department of Internal Medicine, Sassa Medical Clinic, Osaka, Japan
    J Cardiol 52:133-9. 2008
    ..In this study, we investigated whether 64-slice MDCT can non-invasively identify significant coronary artery stenosis in asymptomatic, type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) patients...
  79. ncbi Effect of coronary stenosis on adjacent bed flow reserve: assessment of microvascular mechanisms using myocardial contrast echocardiography
    John J Pacella
    Cardiovascular Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Circulation 114:1940-7. 2006
    During coronary stenosis, flow reserve in the adjacent nonstenotic bed decreases, but the microvascular mechanisms are unknown...
  80. ncbi Fractional flow reserve to guide coronary revascularization
    Nico H J Pijls
    Catharina Hospital, Eindhoven, The Netherlands
    Circ J 77:561-9. 2013
    ..This review can be read as an overview of the state-of-the-art of FFR and as a guide to further reading. ..
  81. ncbi CT coronary angiography: impact of adapted statistical iterative reconstruction (ASIR) on coronary stenosis and plaque composition analysis
    Tobias A Fuchs
    Department of Radiology, Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091 Zurich, Switzerland
    Int J Cardiovasc Imaging 29:719-24. 2013
    ..Modern image reconstruction algorithms such as ASIR, which has been developed for noise reduction in latest high resolution CCTA scans, can be used reliably without interfering with the plaque analysis and stenosis severity assessment...
  82. pmc Takayasu's arteritis with ostial and left main coronary artery stenosis
    G Venkata Ramana Kumar
    P K Sen Department of Cardiovascular and Thoracic Surgery, King Edward Memorial Hospital and Seth G S Medical College, Mumbai 400012, India
    Tex Heart Inst J 34:470-4. 2007
    ..Timely coronary artery bypass grafting relieved our patient's angina, and in early follow-up she has shown good effort tolerance...
  83. ncbi Association of three polymorphisms of scavenger receptor class BI gene (exon8, exon1, intron5) with coronary stenosis in a coronary Tunisian population
    Jihene Rejeb
    Biochemistry Department, UR MSP 28 04, Sahloul University Hospital, Sousse, Tunisia
    Gene 511:383-8. 2012
    ..We tested the relationship of SCARB1 polymorphisms with significant coronary stenosis (SCS) and lipid profile in a coronary Tunisian population.
  84. ncbi Pressure-diameter relationship in human coronary arteries
    Olivier Muller
    Cardiovascular Centre Aalst, OLV Clinic, Belgium
    Circ Cardiovasc Interv 5:791-6. 2012
    ..To quantify the changes in arterial dimensions after the acute changes in pressure associated with percutaneous coronary intervention (PCI)...
  85. ncbi Noninvasive diagnosis of ischemia-causing coronary stenosis using CT angiography: diagnostic value of transluminal attenuation gradient and fractional flow reserve computed from coronary CT angiography compared to invasively measured fractional flow reser
    Yeonyee E Yoon
    Department of Medicine, Seoul National University Hospital, Seoul, Korea
    JACC Cardiovasc Imaging 5:1088-96. 2012
    ....
  86. ncbi Determinants of reduction of coronary flow reserve in patients with type 2 diabetes mellitus or arterial hypertension without angiographically determined epicardial coronary stenosis
    Maurizio Galderisi
    Department of Clinical and Experimental Medicine, Federico II University Hospital of Naples, Naples, Italy
    Am J Hypertens 20:1283-90. 2007
    ..We investigated the determinants of CFR impairment in Type 2 diabetes mellitus (DM2) and in arterial hypertension (HTN) without epicardial coronary artery stenosis...
  87. ncbi Reduced antegrade flow in the coronary sinus is a predictor of coronary artery stenosis in hypertensive patients
    Xiaozhi Zheng
    Department of Ultrasound, Fourth Affiliated Hospital of Nantong University First People s Hospital of Yancheng, Yancheng, China
    J Ultrasound Med 31:7-14. 2012
    ..The purpose of this study was to evaluate the feasibility of assessing blood flow in the coronary sinus by transthoracic Doppler echocardiography for detecting coronary artery stenosis in hypertensive patients...
  88. ncbi Validation of intravascular ultrasound-derived parameters with fractional flow reserve for assessment of coronary stenosis severity
    Soo Jin Kang
    Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Circ Cardiovasc Interv 4:65-71. 2011
    ..We assessed optimal intravascular ultrasound (IVUS) criteria for predicting functional significance of intermediate coronary lesions...
  89. ncbi Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 39:604-9. 2002
    ..The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients...
  90. ncbi Combination of free-breathing and breathhold steady-state free precession magnetic resonance angiography for detection of coronary artery stenoses
    Marc Dewey
    Department of Radiology, Charite Medical School, Free University and Humboldt University, Berlin, Germany
    J Magn Reson Imaging 23:674-81. 2006
    ..To analyze the incremental diagnostic value of a combination of two approaches (free-breathing and breathhold) vs. the sole free-breathing approach to coronary magnetic resonance angiography (CMRA) for detection of significant stenoses...
  91. pmc Does a well developed collateral circulation predispose to restenosis after percutaneous coronary intervention? An intravascular ultrasound study
    D Perera
    Department of Cardiology, Rayne Institute, St Thomas Hospital Campus, King s College London, UK
    Heart 92:763-7. 2006
    ..To evaluate whether a well developed collateral circulation predisposes to restenosis after percutaneous coronary intervention (PCI)...
  92. ncbi Determination of fractional flow reserve (FFR) based on scaling laws: a simulation study
    Jerry T Wong
    Department of Radiological Sciences, University of California, Irvine, CA 92697, USA
    Phys Med Biol 53:3995-4011. 2008
    ..Changes in coronary arterial flow and volume due to coronary stenosis, aortic pressure and venous pressure were examined to evaluate the potential use of flow and volume for FFR ..
  93. ncbi Radiation dose in coronary artery angiography with 320-detector row CT and its diagnostic accuracy: comparison with 64-detector row CT
    T Zhang
    Department of Radiology, Harbin Medical University, Harbin, China
    Minerva Med 102:249-59. 2011
    ..The aim of this study was the comparison of image quality, diagnostic accuracy and radiation dose of ECG-gated volume scan mode of 320-detector row CT with 64-detector row CT...
  94. ncbi Functional and anatomical diagnosis of coronary artery stenoses
    Abhijit Sinha Roy
    Department of Mechanical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0072, USA
    J Surg Res 150:24-33. 2008
    ..We sought to develop a single prognostic parameter correlating stenosis-specific anatomy, pressure gradient, and velocities that could be measured during catheterization...
  95. ncbi [Comparative analysis of atherosclerotic plaque distribution in the left main coronary artery and proximal segments of left anterior descending and left circumflex arteries in patients qualified for percutaneous coronary angioplasty]
    Aneta Iwona Gziut
    Klinika Kardiologii Inwazyjnej, Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji, Warszawa
    Ann Acad Med Stetin 52:51-62; discussion 62-3. 2006
    ..The aim of study was to evaluate plaques in LMS and proximal LAD and LCX segments in patients with symptomatic multivessel coronary disease who underwent PCI...
  96. ncbi Validation of minimal luminal area measured by intravascular ultrasound for assessment of functionally significant coronary stenosis comparison with myocardial perfusion imaging
    Jung Min Ahn
    Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    JACC Cardiovasc Interv 4:665-71. 2011
    ..This study sought to evaluate the ability of minimal luminal area (MLA) measured by intravascular ultrasound (IVUS) to assess the functional significance of coronary artery disease...
  97. ncbi Invasive versus noninvasive evaluation of coronary artery disease
    Joanne D Schuijf
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    JACC Cardiovasc Imaging 1:190-9. 2008
    ....
  98. ncbi Severity of coronary artery disease but not degree of coronary stenosis is correlated to cerebrovascular reactivity
    B Rosengarten
    Center of Neurology and Neurosurgery, Department of Neurology, Justus Liebig University of Giessen, Giessen, Germany
    Cerebrovasc Dis 28:290-7. 2009
    ..Therefore, we hypothesize that early indicators of cerebrovascular disease such as parameters of the neurovascular coupling show a higher correlation to coronary artery disease than morphologic parameters...
  99. ncbi Learning curve for coronary CT angiography: what constitutes sufficient training?
    Francesca Pugliese
    Department of Radiology, Erasmus MC University Medical Centre Rotterdam, Dr Molewaterplein 40, 3015GD Rotterdam, The Netherlands
    Radiology 251:359-68. 2009
    ..To prospectively evaluate the effect of experience with coronary computed tomographic (CT) angiography on the capability to detect coronary stenoses of 50% or more...
  100. ncbi Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model
    Tuomo Nieminen
    Department of Pharmacological Sciences, Medical School, University of Tampere, Finland
    Heart Rhythm 8:608-14. 2011
    ....
  101. ncbi Long-term results of saphenous vein graft for coronary stenosis caused by Kawasaki disease
    Yuko Wakisaka
    Department of Pediatrics, National Cardiovascular Center, Suita, Japan
    Circ J 73:73-7. 2009
    Although saphenous vein grafts (SVG) have been used from 1975 to treat coronary stenosis caused by Kawasaki disease, long-term results after more than 20 years remain unknown.

Research Grants63

  1. Amplification of Cardiosphere-Derived Cell Therapy
    BRIAN RAYMOND WEIL; Fiscal Year: 2013
    ..myocardial contractile function and perfusion in swine with hibernating myocardium resulting from a chronic coronary stenosis. In Aim 2, the ability of Y-CDCs and A-CDCs to increase myocyte nuclear density, stimulate myocyte ..
  2. Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction
    Carl J Pepine; Fiscal Year: 2013
    ..An additional subgroup of 200 women with no coronary stenosis >20% in any epicardial coronary artery will undergo CRT...
  3. SFRP2, cell survival, and coronary vascular angiogenesis
    DOROTHY EILEEN VATNER; Fiscal Year: 2013
    ..Therefore, we developed a swine model of repetitive episodes of low-flow coronary stenosis, which reproduces the conditions of transient and repeated ischemic episodes found in patients with ischemic ..
  4. Role of RTN-4 in Atherosclerosis
    Jun Yu; Fiscal Year: 2013
    ..The ApoE-/-Nogo-/- mice also developed severe coronary stenosis, a phenotype that is rarely observed in current mouse models of atherosclerosis...
  5. Chemokines and Neovascularization in Coronary Artery Disease
    ELLEN CATHERINE KEELEY; Fiscal Year: 2013
    ..A striking, but mechanistically unexplained, clinical observation is that patients with similar degrees of coronary stenosis and myocardial ischemia have markedly heterogenous extent of myocardial neovascularization...
  6. STICH Trial-Statistical and Data Coordinatiing Center
    Kerry L Lee; Fiscal Year: 2010
    ..These patients first will be characterized by angina intensity or presence of left main coronary stenosis as appropriate for only surgical therapy or either medical or surgical therapy...
  7. Blood Markers of Vulnerability in High Risk Vascular Patients
    Mary Mcgrae McDermott; Fiscal Year: 2012
    ..Findings may help clinicians identify patients who are at particularly high-risk for an impending heart attack. Results are also expected to elucidate specific triggers of acute coronary events. ..
  8. STICH Trial-Coordinating Center
    Robert H Jones; Fiscal Year: 2011
    ..These patients first will be characterized by angina intensity or presence of left main coronary stenosis as appropriate for only surgical therapy or either medical or surgical therapy...
  9. In Vivo Myocardial Microcirculatory Function
    ERIK LEO RITMAN; Fiscal Year: 2010
    ..abstract_text> ..
  10. Gender-Specific Coronary Plaque Characteristics and Risk of Myocardial Infarction
    James K Min; Fiscal Year: 2013
    ..Coronary CT angiography (CT) is a non-invasive test that permits diagnosis of coronary stenosis with high diagnostic accuracy in women and men, as well as evaluation of atherosclerotic plaque and coronary ..
  11. RESCUE: Randomized Evaluation of Patients with Stable Angina Comparing Utilizatio
    Arthur E Stillman; Fiscal Year: 2010
    ..Compare the effectiveness of computed tomography (CT) angiography and conventional angiography in assessing coronary stenosis in patients at moderate pretest risk of coronary artery disease...
  12. HIV Infection, Cocaine Use and Coronary Artery Disease in HIV+ African Americans
    Shenghan Lai; Fiscal Year: 2012
    ....
  13. CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
    WILLIAM SANTAMORE; Fiscal Year: 1990
    ..This new knowledge will be of vital importance to millions of Americans suffering from coronary heart disease and may help to interpret clinical data and shape future therapy...
  14. Fractional flow reserve measurement based on coronary angiographic images
    SABEE Y MOLLOI; Fiscal Year: 2010
    ..Furthermore, pathologic findings have shown a lack of correlation between the severity of coronary stenosis as estimated from coronary arteriogram and the actual severity of stenotic lesions measured in postmortem ..
  15. MYOCARDIAL ISCHEMIA INDUCED BY INHALED ANESTHETICS
    CHARLES BUFFINGTON; Fiscal Year: 1993
    ..In parallel laboratory experiments, both halothane and isoflurane will be administered to dogs with a coronary stenosis. Measurements of transmural perfusion (microspheres), myocardial metabolism (oxygen consumption and lactate ..
  16. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..3. Whether phasic changes in MBV can be used to detect the presence and magnitude of coronary stenosis at rest. 4. Whether changes in blood viscosity affect coronary blood flow reserve...
  17. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..3. Whether phasic changes in MBV can be used to detect the presence and magnitude of coronary stenosis at rest. 4. Whether changes in blood viscosity affect coronary blood flow reserve...
  18. QUANTITATIVE CORONARY ANGIOGRAPHY BY DUAL ENERGY DSA
    Sabee Molloi; Fiscal Year: 1993
    ..Furthermore, pathologic findings have shown a lack of correlation between the severity of coronary stenosis as estimated from coronary angiograms and the actual severity of stenotic lesions measured in postmortem ..
  19. Early Noninvasive Detection of Myocardial Microbascular Dysfunction in Diabetes
    Angela M Taylor; Fiscal Year: 2013
    ..End of Abstract) ..
  20. QUANTITATIVE VENTRICULOGRAPHY USING DUAL-ENERGY DSA
    MICHAEL VAN LYSEL; Fiscal Year: 1992
    ..Furthermore, these techniques have the potential to provide a high resolution outpatient test for coronary artery disease and for the serial assessment of rest and exercise ventricular function in patients with cardiac disease...
  21. TECHNIQUES FOR DETECTION OF LESIONS IN CORONARY ARTERIES
    HOWARD KANTOR; Fiscal Year: 1991
    ..evaluate these techniques in the following systems: a) a phantom 2-5 mm polyvinyl chloride tubing model of coronary stenosis with pulsatile flow and associated with a model of respiratory related motion, b) a porcine model of ..
  22. FUNCTIONAL CHARACTERISTICS OF THE LEFT HEART
    HAROLD DODGE; Fiscal Year: 1990
    ..and global left and right ventricular performance in myocardial infarction, (2) the effect of residual coronary stenosis on regional ventricular performance after thrombolytic therapy in myocardial infarction, (3) regional ..
  23. THROMBOLYSIS IN MYOCARDIAL ISCHEMIA COORDINATING CENTER
    Genell Knatterud; Fiscal Year: 1992
    ....
  24. IMAGING INTIMAL HYPERPLASIA, MYOCYTE HYPOXIA, NECROSIS
    Lynne Johnson; Fiscal Year: 2000
    ..may be a sensitive marker for very early and very mild myocyte necrosis occurring with pacing and underlying coronary stenosis. BMS-194796, a nitroheterocycle, is retained in hypoxic tissue...
  25. MYOCARDIAL ISCHEMIA AND CORONARY ARTERY REPERFUSION
    STEPHEN VATNER; Fiscal Year: 2000
    ..to ischemia, and potentially part of the mechanism of maintenance of blood flow with subacute and chronic coronary stenosis. (2) Myocardial stunning and myocardial hibernation have similar mechanisms...
  26. ECHOCARDIOGRAPHY OF REGIONAL MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 1990
    ..perfusion and function and the inadequacy of coronary angiography in determining the significance of coronary stenosis. During my work with myocardial contrast agents, I became interested in their potential use for determining ..
  27. Innovative Cardiac Imaging Phantom Approach for Tc-99
    SHELBY CULLOM; Fiscal Year: 2003
    ..abstract_text> ..
  28. CORONARY FLOW RESERVE BY AUTOMATED QUANTITATIVE PET
    K Gould; Fiscal Year: 1992
    ....
  29. Coronary Vasa Vasorum - Role of 3D Branching Geometry
    Erik Ritman; Fiscal Year: 2009
    ..abstract_text> ..
  30. DIASTOLIC RELAXATION IN ISCHEMIA/HYPERTROPHY/FAILURE
    William Grossman; Fiscal Year: 1992
    ..The research program will provide new information important to the basic understanding of myocardial relaxation and for the clinical care of patients with diastolic dysfunction...
  31. Sustained Coronary Stenosis and Hibernating Myocardium
    RAYMOND KUDEJ; Fiscal Year: 2005
    ..acquired from this proposal will be directly applicable to humans with coronary artery disease and chronic coronary stenosis. Additionally, understanding the basic mechanisms underlying the enhanced performance of myocardial tissue ..
  32. Myocardial Perfusion Quantitation with Dual Spectra Echo
    Marek Belohlavek; Fiscal Year: 2006
    ..Aim 4: Validate the new method for quantitation of myocardial perfusion during coronary stenosis. Aim 5: Validate the dual spectrum method for perfusion quantitation in microvascular obstruction...
  33. THROMBOLYSIS IN MYOCARDIAL ISCHEMIA-CLINICAL APPLICATION
    Eugene Braunwald; Fiscal Year: 1992
    ..aims: (1) To determine if t-PA produces improvement in angiographically determined myocardial perfusion or coronary stenosis (TIMI IIIA); and, (2) to identify the optimal initial and follow-up management strategy (TIMI IIIB)...
  34. STICH TRIAL - NEUROHORMONAL/ CYTOKINE/ GENETIC CORE LAB
    Arthur Feldman; Fiscal Year: 2007
    ..These patients first will be characterized by angina intensity or presence of left main coronary stenosis as appropriate for only surgical therapy or both medical and surgical therapy...
  35. CHD INCIDENCE, MORTALITY, RISK FACTOR RELATIONSHIPS
    THOMAS KOTTKE; Fiscal Year: 1990
    ..needs for therapeutic procedures such as ventricular assist devices, artificial hearts, laser catheters for coronary stenosis, etc...
  36. ANGIOGRAPHIC IMAGING OF CORONARY LESION MORPHOLOGY
    James Whiting; Fiscal Year: 1992
    ..Thus, the potential health related impact of this research may be a more accurate means of identifying high risk coronary lesions and thus improve clinical decision making in patients with coronary artery disease...
  37. Echocardiographic Evaluation of Endothelial Function
    Flordeliza Villanueva; Fiscal Year: 2005
    ..abstract_text> ..
  38. STICH-Trial Cardiovascular Magenetic Resonance Core Lab
    Gerald Pohost; Fiscal Year: 2007
    ..These patients first will be characterized by angina intensity or presence of left main coronary stenosis as appropriate for only surgical therapy or either medical or surgical therapy...
  39. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007
    ..These patients first will be characterized by angina intensity or presence of left main coronary stenosis as appropriate for only surgical therapy or either medical or surgical therapy...
  40. STICH Trial-Echocardiographic Core Laboratory
    Jae Oh; Fiscal Year: 2007
    ..These patients first will be characterized by angina intensity or presence of left main coronary stenosis as appropriate for only surgical therapy or either medical or surgical therapy...
  41. COAGULATION AND FIBRINOLYSIS IN TIMI III
    Kenneth Mann; Fiscal Year: 1991
    ..aims: 1) to determine if rt-PA produces improvement in angiographically determined myocardial perfusion or coronary stenosis (TIMI III A); and 2) to identify the optimal initial and follow-up management strategy (TIMI III B)...
  42. THROMBOLYSIS IN MYOCARDIAL ISCHEMIA-CORE APPLICATION
    Eugene Braunwald; Fiscal Year: 1991
    ..A special strength of the application is the prior experience of each of the laboratories with the tasks they will perform in TIMI III...
  43. ASSESSMENT OF MYOCARDIAL PERFUSION & VIABILITY
    George Beller; Fiscal Year: 1992
    ..redistribution at rest will be more accurate for identifying viable but underperfused myocardium distal to a coronary stenosis, than MIBI uptake; (2) MIBI uptake patterns will underestimate degree of myocardial salvage during ..
  44. PHONOANGIOGRAPHIC SPECTRAL ANALYZER FOR CORONARY ARTERY
    KENNETH SCHLAGER; Fiscal Year: 1991
    A reliable and inexpensive noninvasive procedure for detecting coronary stenosis would be highly useful in the diagnosis and in following the treatment of coronary artery disease...
  45. IMAGING MYOCARDIAL PERFUSION WITH NMR
    Robert Weisskoff; Fiscal Year: 1999
    ....
  46. MRI-Guided Angioplasty of Coronary Artery Stenosis
    Debiao Li; Fiscal Year: 2006
    ..After more experience is gained, we anticipate a shift towards MIRI guidance for coronary interventions because of its capability to perform accurate functional assessment at the time of the intervention. ..
  47. EPIDEMIOLOGY OF CORONARY ARTERY CALCIFICATION
    PATRICIA PEYSER; Fiscal Year: 2005
    ....
  48. ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTER
    Carl Pepine; Fiscal Year: 2001
    ..disease, and to determine the frequency of myocardial ischemia in the absence of significant epicardial coronary stenosis, as well as the frequency of non-ischemic or non-cardiac chest pain...
  49. HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEA
    Andrew Levy; Fiscal Year: 2003
    ....
  50. CONSOLE FOR 2-0 T MRI SPECTROMETER
    JEROME ACKERMAN; Fiscal Year: 1990
    ..The quality and productivity of both current and future PHS-supported health research will be enormously enhanced by the acquisition of the instrumentation requested in this proposal...
  51. DYNAMICS OF NORMAL & STENOTIC CORONARY ARTERIES
    Jeffrey Schwartz; Fiscal Year: 1990
    ..In the presence of a severe compliant coronary stenosis, even small changes in the area of the stenosis due to physiologic processes or to drugs may importantly ..
  52. Detection of Coronary Stenoses Using T2-Weighted MRI
    Debiao Li; Fiscal Year: 2006
    ..Positive results from this project will warrant clinical studies in patients to evaluate the role of T2-weighted MR imaging in detecting functionally significant coronary artery disease. ..
  53. CT ANALYSIS OF MYOCARDIAL MICROCIRCULATORY FUNCTION
    Erik Ritman; Fiscal Year: 2000
    ..The investigators propose that the contrast for these studies can be injected interveneously, and therefore the technique will be less invasive than intra-arterial coronary angiography. ..
  54. TECHNIQUES FOR DETECTION OF LESIONS IN CORONARY ARTERIES
    Erik Ritman; Fiscal Year: 1990
    ..other demonstrated capabilities of the DSR images, provide quantitation of the presence and severity of a coronary stenosis, the volume of the plaque causing the stenosis and the impact on myocardial perfusion distal to the stenosis;..
  55. HIGH RESOLUTION INTERACTIVE CORONARY ARTERY MRA
    Stephen Riederer; Fiscal Year: 2002
    ..The methods will be studied in a pig model of coronary artery stenosis and compared with x-ray angiography. ..
  56. Inhomogeneous Sympathetic Innervation in IHD
    JAMES FALLAVOLLITA; Fiscal Year: 2008
    ..Therefore, these studies will translate basic observations in animals to clinical pathophysiology in humans and identify novel substrate factors that contribute to the risk of SD in chronic ischemic heart disease. ..
  57. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..