Genomes and Genes
Summary: Thickening and loss of elasticity of the coronary arteries, leading to progressive insufficiency of the arteries (CORONARY DISEASE).
Publications210 found, 100 shown here
- Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-upEmmanouil S Brilakis
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Eur Heart J 26:137-44. 2005..We aimed to evaluate the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with coronary artery disease (CAD) risk factors, with the severity of angiographic CAD, and with the incidence of major adverse events...
- Coronary artery calcification and family history of premature coronary heart disease: sibling history is more strongly associated than parental historyKhurram Nasir
The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circulation 110:2150-6. 2004....
- Atherogenic lipoprotein particles in atherosclerosisRafael Carmena
Department of Endocrinology and Nutrition, Facultad de Medicina y Hospital Clinico Universitario, Valencia, Spain
Circulation 109:III2-7. 2004..Ultimately, better understanding of the roles of these lipid particles and subfractions in the initiation and progression of atherosclerosis may affect treatment decisions...
- Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null miceKazuhiko Inoue
Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565 8565 Osaka, Japan
Circ Res 97:176-84. 2005....
- Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trialDavid D Waters
Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
JAMA 288:2432-40. 2002..Hormone replacement therapy (HRT) and antioxidant vitamins are widely used for secondary prevention in postmenopausal women with coronary disease, but no clinical trials have demonstrated benefit to support their use...
- Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repairCaroline Schmidt-Lucke
Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
Circulation 111:2981-7. 2005..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
- Prognostic value of coronary vascular endothelial dysfunctionJulian P J Halcox
Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Circulation 106:653-8. 2002....
- T1 and M1 polymorphism in glutathione S-transferase gene and coronary artery disease in North Indian populationK M Girisha
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
Indian J Med Sci 58:520-6. 2004..In the present study the contribution of the polymorphism in the glutathione S-transferase gene to the development of coronary artery disease has been investigated...
- Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individualsPhilip Greenland
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill 90502, USA
JAMA 291:210-5. 2004..Although the Framingham Risk Score (FRS) is often recommended for this, it has been suggested that risk assessment may be improved by additional tests such as coronary artery calcium scoring (CACS)...
- Association of hypoadiponectinemia with coronary artery disease in menMasahiro Kumada
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Arterioscler Thromb Vasc Biol 23:85-9. 2003..This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD)...
- KLOTHO allele status and the risk of early-onset occult coronary artery diseaseDan E Arking
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hum Genet 72:1154-61. 2003..Modifiable risk factors, including hypertension, smoking status, and HDL-C level, appear to influence the risk imposed by this allele...
- Coronary artery, aortic wall, and valvular calcification in nondialyzed individuals with type 2 diabetes and renal diseaseRaffi Merjanian
Division of Nephrology and Hypertension, Department of Pediatrics, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90502, USA
Kidney Int 64:263-71. 2003..We undertook this study to test the hypothesis that vascular and valvular calcification begins and is often severe long before diabetic renal disease progresses to ESRD...
- Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery riskSerena Masetti
Sant Anna School, Pisa, Italy
J Mol Med (Berl) 81:488-94. 2003..These observations suggest that GST-null genotypes strengthen the effect of smoking on CAD risk by modulating the detoxification of genotoxic atherogens...
- Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) studyEric A Miller
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Atherosclerosis 171:265-72. 2003..The results of this study provide some limited evidence that GSTM1 and GSTT1 polymorphisms modify the effect of smoking on inflammation, hemostasis, and endothelial function...
- Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteriesJ Eduardo Sousa
Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil
Circulation 107:381-3. 2003..We sought to evaluate the angiographic, intravascular ultrasound (IVUS), and clinical outcomes of patients treated with sirolimus-eluting stents 2 years after implantation...
- E-selectin S128R polymorphism and severe coronary artery disease in ArabsKhaled K Abu-Amero
Genetics Department, King Faisal Specialist Hospital and Research Centre MBC 03, P, O, Box 3354, Riyadh 11211, Saudi Arabia
BMC Med Genet 7:52. 2006..The E-selectin p. S128R (g. A561C) polymorphism has been associated with the presence of angiographic coronary artery disease (CAD) in some populations, but no data is currently available on its association with CAD in Arabs...
- Efficacy of case method learning in general practice for secondary prevention in patients with coronary artery disease: randomised controlled studyAnna Kiessling
Centre for Clinical Education, Danderyd University Hospital and Karolinska Institute, SE 182 88 Stockholm, Sweden
BMJ 325:877-80. 2002..To study the efficacy of case method learning, for general practitioners, on patients' lipid concentrations in the secondary prevention of coronary artery disease...
- Prognostic significance of plasma concentrations of transforming growth factor-beta in patients with coronary artery diseaseHideki Tashiro
Division of Cardiology, St Mary s Hospital, Kurume, Japan
Coron Artery Dis 13:139-43. 2002..In this study, we examined whether those alterations in plasma levels of cytokines have a prognostic significance in patients with CAD...
- Human epicardial adipose tissue is a source of inflammatory mediatorsTomasz Mazurek
Department of Surgery, Thomas Jefferson University, Suite 623, 1025 Walnut St, Philadelphia, PA 19107, USA
Circulation 108:2460-6. 2003..In this study, we sought to compare expression of inflammatory mediators in epicardial and subcutaneous adipose stores in patients with critical CAD...
- Adipokines: molecular links between obesity and atheroslcerosisDavid C W Lau
Department of Medicine, Julia McFarlane Diabetes Research Center, University of Calgary, Calgary, Canada
Am J Physiol Heart Circ Physiol 288:H2031-41. 2005..Finally, we will discuss how these new insights may provide us with innovative therapeutic strategies to improve cardiovascular health...
- Echolucent carotid plaques predict future coronary events in patients with coronary artery diseaseOsamu Honda
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
J Am Coll Cardiol 43:1177-84. 2004..The purpose of this study was to examine whether echolucent carotid plaques predict future coronary events in patients with clinically stable coronary artery disease (CAD)...
- Increased Th1 activity in patients with coronary artery diseaseJuliano L Fernandes
Heart Institute InCor, University of Sao Paulo Medical School, Brazil
Cytokine 26:131-7. 2004....
- Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) projectAllen J Taylor
Department of Medicine, Cardiology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
J Am Coll Cardiol 46:807-14. 2005..We sought to examine the independent predictive value of coronary artery calcium detection for coronary outcomes in a non-referred cohort of healthy men and women ages 40 to 50 years...
- Predictive value of associations between carotid and coronary artery disease in patients with acute coronary syndromesRoman Komorovsky
Cardiovascular Research Foundation, Department of Angiology, S Giacomo Hospital, Castelfranco Veneto, Italy
Am J Cardiol 95:116-9. 2005..In treatment-stratified Cox's proportional hazards regression analysis, hard carotid plaques and coronary lesions of complex morphology were found to be independent predictors of future cardiac events...
- Getting to the heart of social support: a qualitative analysis of the types of instrumental support that are most helpful in motivating cardiac risk factor modificationCarla Boutin-Foster
The Joan and Sanford I Weill Medical College, Cornell University, New York, NY 10021, USA
Heart Lung 34:22-9. 2005..This study evaluates the types of instrumental social support that are perceived by patients with coronary artery disease as being most helpful to health behavior modification...
- Cardiovascular risk scores and the presence of subclinical coronary artery atherosclerosis in women with systemic lupus erythematosusC P Chung
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
Lupus 15:562-9. 2006..Measurement of coronary calcification may add information to identify asymptomatic women with lupus who might benefit from aggressive preventive measures...
- Associations of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery diseaseJohn R Crouse
Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Circulation 106:2061-6. 2002..Few studies have explored the association of risk factors with progression of IMT, and none have evaluated their associations with IMT progression specifically in patients with and without CAD...
- Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissueNoriyuki Ouchi
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Circulation 107:671-4. 2003..The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue...
- Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriographySun Ha Jee
Department of Epidemiology and Health Promotion, Graduate School of Health Science and Management, Yonsei University, Seoul 120 752, South Korea
Hum Genet 111:128-35. 2002..The results of this study also indicated that multifactorial inheritance was supported more strongly than Mendelian inheritance alone. Our findings may have implications for attempts to identify new homocysteine susceptible genes...
- Paclitaxel coating reduces in-stent intimal hyperplasia in human coronary arteries: a serial volumetric intravascular ultrasound analysis from the Asian Paclitaxel-Eluting Stent Clinical Trial (ASPECT)Myeong Ki Hong
Department of Medicine, University of Ulsan College of Medicine, Songpa Gu, Seoul, Korea
Circulation 107:517-20. 2003..The aim of this study was to use serial volumetric intravascular ultrasound (IVUS) to evaluate the effect of a paclitaxel coating on in-stent intimal hyperplasia (IH)...
- Effects of exercise and diet on chronic diseaseChristian K Roberts
Dept of Physiological Science, University of California Los Angeles, 4101 Life Sciences Bldg, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
J Appl Physiol (1985) 98:3-30. 2005....
- Usefulness of insulin resistance measured by homeostasis model assessment in predicting restenosis after coronary stent placement in nondiabetic patientsMakoto Sekiguchi
Department of Medicine and Biological Science, Graduate School of Medicine, Gunma University, Maebashi, Japan
Am J Cardiol 93:920-2. 2004..Our findings suggest that insulin resistance measured by the homeostasis model assessment predicts restenosis after coronary stent placement in nondiabetic patients...
- A tertiary care hospital-based study of conventional risk factors including lipid profile in proven coronary artery diseasePravin K Goel
Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow
Indian Heart J 55:234-40. 2003..Most data on lipid levels in Indians have been obtained from studies on migrant Asian Indians. There are insufficient data on lipid profile and other conventional risk factors in Indian patients living within India...
- Drug-eluting stents: clinical experiences and perspectivesE Grube
Heart Center Siegburg, Siegburg, Germany, Italy
Minerva Cardioangiol 50:469-73. 2002..Nevertheless, we need more trials and an agreement of definitions in order to evaluate this treatment concept and eliminate unwanted side-effects...
- Significant reduction in restenosis after the use of sirolimus-eluting stents in the treatment of chronic total occlusionsAngela Hoye
Department of Interventional Cardiology, Erasmus MC, Rotterdam, The Netherlands
J Am Coll Cardiol 43:1954-8. 2004..The aim of this study was to assess sirolimus-eluting stent (SES) implantation for the treatment of chronic total coronary occlusions (CTO)...
- Undertreatment of hyperlipidemia in patients with coronary artery disease and heart failureCarla A Sueta
Medical Review of North Carolina, Cary, North Carolina 27511, USA
J Card Fail 9:36-41. 2003..We examined the frequency of lipid assessment and prescription of lipid-lowering agents in outpatients with combined CAD+HF compared with patients with CAD alone...
- Clinical implications of carotid artery remodeling in acute coronary syndrome: ultrasonographic assessment of positive remodelingMasaya Kato
Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan
J Am Coll Cardiol 42:1026-32. 2003..We investigated the relationship between ultrasonographic features of the carotid artery and the angiographic features of coronary plaques in acute coronary syndrome (ACS)...
- Correlation of coronary arterial remodeling determined by intravascular ultrasound with angiographic diameter reduction of 20% to 60%Makoto Hirose
Cardiovascular Research Foundation, New York, NY 10021, USA
Am J Cardiol 92:141-5. 2003..7) were similar. Negative remodeling is frequently observed in lesions with intermediate stenosis. This suggests that negative remodeling occurs early in lesion formation...
- Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasisNatalie Khuseyinova
Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
Atherosclerosis 182:181-8. 2005..12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD...
- Transcription factor MEF2A mutations in patients with coronary artery diseaseM R Krishna Bhagavatula
Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Hum Mol Genet 13:3181-8. 2004..93%) may carry mutations in MEF2A, although further definition of the prevalence of MEF2A mutations is warranted...
- Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosisMuredach P Reilly
Cardiovascular Division and Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Circulation 110:803-9. 2004....
- Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factorsCecilia P Chung
Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
Arthritis Rheum 52:3045-53. 2005..To compare the prevalence and severity of coronary-artery atherosclerosis in patients with early and established rheumatoid arthritis (RA) and controls...
- Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up studyPeter H Stone
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
Circulation 108:438-44. 2003..The endothelium controls local arterial responses by transduction of shear stress. Characterization of endothelial shear stress (ESS) may allow for prediction of progression of atherosclerosis and in-stent restenosis...
- Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery diseaseGianluca Iacobellis
Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy
Cytokine 29:251-5. 2005..Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin...
- Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjectsErnst J Schaefer
Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA
Am J Cardiol 95:1025-32. 2005....
- Association of increased carotid intima-media thickness with the extent of coronary artery diseaseA Kablak-Ziembicka
Department of Cardiac and Vascular Diseases, The John Paul II Hospital, Krakow, Poland
Heart 90:1286-90. 2004..The coexistence of severe extracranial atherosclerosis in patients with CAD was also analysed...
- Risk factors for acute myocardial infarction in a rural population of central India: a hospital-based case-control studySamir S Patil
Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442102, Maharashtra, India
Natl Med J India 17:189-94. 2004..We conducted a prospective case-control study to determine the risk factors for acute myocardial infarction in a rural population of central India...
- Coronary artery calcium score, risk factors, and incident coronary heart disease eventsTimothy S Church
The Cooper Institute, Dallas, TX 75230, United States
Atherosclerosis 190:224-31. 2007..We sought to identify a potential threshold of coronary artery calcium for clinical use and examine the predictive power of coronary artery calcium in individuals categorized using conventional coronary heart disease risk assessment...
- Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery diseaseTetsuro Miyazaki
Department of Cardiology, Juntendo University School of Medicine, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
Atherosclerosis 179:139-45. 2005..However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined...
- Markers of endothelial dysfunction in the prediction of coronary artery disease in type 1 diabetes. The Pittsburgh Epidemiology of Diabetes Complications StudyTina Costacou
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
J Diabetes Complications 19:183-93. 2005..13, 95% Cl=1.03-1.24; HRs are per standard deviation increase) but not hard CAD. Study results suggest that E-selectin may enhance CAD prediction beyond traditional risk factors or markers of oxidative stress in Type 1 diabetes...
- Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion developmentA H Schoneveld
Department of Cardiology, Experimental Cardiology Laboratory, UMC, Heidelberglaan 100, Room G02 523, 3584 CX Utrecht, The Netherlands
Cardiovasc Res 66:162-9. 2005..Here, we determined whether Tlr2 stimulation promotes pro-inflammatory cytokine/chemokine production in vitro and augments neointima formation and development of atherosclerotic plaques in vivo...
- Added value of attenuation-corrected Tc-99m tetrofosmin SPECT for the detection of myocardial viability: comparison with FDG SPECTRiemer H J A Slart
Department of Nuclear Medicine, Groningen University Medical Center, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
J Nucl Cardiol 11:689-96. 2004..The aim of this study was to evaluate the value of attenuation correction of technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging for the detection of myocardial viability...
- Do longer delays for coronary artery bypass surgery contribute to preoperative mortality in less urgent patients?Boris G Sobolev
Department of Health Care and Epidemiology, The University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada
Med Care 44:680-6. 2006..We evaluated whether longer delays contribute to the probability of death before surgery among patients prioritized into the less urgent category...
- Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery diseaseSteven E Nissen
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
N Engl J Med 352:29-38. 2005..Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression...
- Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosisEleonora Simeoni
Division of Cardiology, University of Lausanne, Switzerland
Eur Heart J 25:1438-46. 2004..In a case-control study, we explored relations between these polymorphisms and coronary artery disease (CAD), with respect to angiographic abnormalities and acute coronary syndromes (ACS)...
- Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglyceridesHilary Coon
Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
Hum Genet 117:444-51. 2005..This study replicates the involvement of USF1 in FCHL and related lipid traits in a family sample not ascertained for FCHL...
- CT measurement of coronary calcium mass: impact on global cardiac risk assessmentChristoph R Becker
Department of Clinical Radiology, Ludwig Maximilians University Hospital Munich, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
Eur Radiol 15:96-101. 2005..The coronary calcium mass and age-related scoring system may have impact on the reassignment of patients with an intermediate Framingham risk to a lower or higher risk group...
- Genetic susceptibility to coronary artery disease: from promise to progressHugh Watkins
Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 9DU, UK
Nat Rev Genet 7:163-73. 2006..Recent findings particularly highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer...
- Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis diseaseH L Geng
Department of Laboratory Diagnosis, Changzheng Hospital, Second Military Medical University, Shanghai, China
Clin Exp Immunol 143:269-73. 2006..was to investigate the expression of TLR4 on peripheral-blood mononuclear cells (PBMCs) in patients with coronary arteriosclerosis disease (CAD)...
- A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart StudyNilesh J Samani
Department of Cardiovascular Sciences, University of Leicester, UK
Am J Hum Genet 77:1011-20. 2005..The exclusion of a common locus that increases risk of CAD to siblings by >50% has important implications for strategies for further defining the genetic basis of CAD...
- Collateral-flow measurements in humans by myocardial contrast echocardiography: validation of coronary pressure-derived collateral-flow assessmentRolf Vogel
Department of Cardiology, University Hospital Bern, CH 3010 Bern, Switzerland
Eur Heart J 27:157-65. 2006..The aims of this human study are (i) to test whether measurements of collateral-derived MBF by MCE are feasible during elective angioplasty and (ii) to validate the concept of pressure-derived collateral-flow assessment...
- Hormone therapy, lipoprotein subclasses, and coronary calcification: the Healthy Women StudyRachel H Mackey
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Arch Intern Med 165:510-5. 2005..To test this hypothesis, we evaluated differences in coronary calcification, lipids, and lipoprotein subclasses among HT users and nonusers in a longitudinal study of the menopause...
- Glutathione S-transferase gene polymorphism as a susceptibility factor in smoking-related coronary artery diseaseLulufer Tamer
Mersin University Medical Faculty, Department of Biochemistry, 33079, Mersin Turkey
Basic Res Cardiol 99:223-9. 2004..20 (1.37 - 7.45)) were at a higher risk for developing coronary heart disease. In conclusion, the finding of a significant association between GSTM1 and T1 with smoking status may influence cardiovascular disease via DNA damage...
- Safety and cardiac chronotropic responsiveness to the early injection of atropine during dobutamine stress echocardiography in the elderlyJ M Tsutsui
Echocardiography Laboratory, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
Heart 91:1563-7. 2005..To determine the safety and cardiac chronotropic responsiveness to early atropine dobutamine stress echocardiography (DSE) in the elderly...
- Coronary artery disease in Saudi ArabiaMansour M Al-Nozha
Taiba University, PO Box 344, Madina Al Munawarah, Kingdom of Saudi Arabia
Saudi Med J 25:1165-71. 2004..Further, to determine the prevalence and clinical pattern of the major modifiable risk factors for CAD among the same population. This work is part of a major national study on CAD in Saudis Study (CADISS)...
- Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomographyDaniel S Berman
Department of Imaging, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Am Coll Cardiol 44:923-30. 2004....
- Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian IndiansLu Fang
Johns Hopkins Singapore National Heart Centre Vascular Biology Program, National University of Singapore
Indian J Med Res 121:92-9. 2005....
- TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesionsEberhard Grube
Department of Cardiology Angiology, Heart Center Siegburg, Siegburg, Germany
Circulation 107:38-42. 2003..The TAXUS I trial was the first in-human experience evaluating safety and feasibility of the TAXUS NIRx stent system compared with bare NIR stents (control) (Boston Scientific Corp) for treatment of coronary lesions...
- Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesionsAntonio Colombo
Ospedale San Raffaele, Milano, Italy
Circulation 108:788-94. 2003..Early clinical studies demonstrated the feasibility of local paclitaxel delivery in reducing restenosis after treatment of de novo coronary lesions in small patient populations...
- Coronary artery calcification and cardiovascular risk factors: impact of the analytic approachMuredach P Reilly
Cardiovascular Division, Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19004 6160, USA
Atherosclerosis 173:69-78. 2004..We present analytic approaches that are likely to provide consistent results and recommend the use of at least two distinct multivariable methods...
- Significance of plasma nitric oxide/endothelial-1 ratio for prediction of coronary artery diseaseAkira Kurita
Department of Biomedical Engineering and Internal Medicine, National Defensse Medical College, Saitma, Japan
Angiology 56:259-64. 2005..The present results suggest that plasma NO/ET-1 ratio is a useful biological marker for predicting CAD...
- Safety and efficacy of bariatric surgery in patients with coronary artery diseaseFrancisco Lopez-Jimenez
Department of Internal Medicine and Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mayo Clin Proc 80:1157-62. 2005..To determine the safety and efficacy of bariatric surgery in obese patients with documented coronary artery disease (CAD)...
- In vivo quantitative tissue characterization of human coronary arterial plaques by use of integrated backscatter intravascular ultrasound and comparison with angioscopic findingsMasanori Kawasaki
Second Department of Internal Medicine, Gifu University School of Medicine, Japan
Circulation 105:2487-92. 2002..The purpose of the present study was to define whether integrated backscatter (IB) combined with conventional intravascular ultrasound (IVUS) makes tissue characterization of coronary arterial plaques possible...
- The influence of left ventricular hypertrophy on survival in patients with coronary artery disease: do race and gender matter?Mark A East
Outcomes Research and Assessment Group, The Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina 27715, USA
J Am Coll Cardiol 41:949-54. 2003..We sought to determine the overall prognostic importance of left ventricular hypertrophy (LVH) among patients with coronary artery disease (CAD), as well as to determine whether this risk varies as a function of race or gender...
- Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery Lesions) trialPatrick W Serruys
Thoraxcentre, Rotterdam, The Netherlands
Circulation 106:798-803. 2002..The goal of this intravascular ultrasound investigation was to provide a more detailed morphological analysis of the local biological effects of the implantation of a sirolimus-eluting stent compared with an uncoated stent...
- Coronary artery calcium scanning: Clinical paradigms for cardiac risk assessment and treatmentHarvey S Hecht
Lenox Hill Heart and Vascular Institute, New York, NY 10021, USA
Am Heart J 151:1139-46. 2006..Physician awareness of this technology and its appropriate uses and limitations is crucial to appropriate use...
- Role of surrogate markers in assessing patients with diabetes mellitus and the metabolic syndrome and in evaluating lipid-lowering therapyVenkataraman Rajaram
Rush University Medical Center, Chicago, Illinois, USA
Am J Cardiol 93:32C-48C. 2004..Thus, surrogate markers may not only help improve individual patient outcomes, they also may help direct scarce medical resources to maximize medical benefits, improve overall medical care, and minimize costs and untoward side effects...
- The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries (C-SIRIUS)Erick Schampaert
Hopital du Sacre Coeur de Montreal, 5400 Bl Gouin O, Montreal, Quebec, Canada H4J 1C5
J Am Coll Cardiol 43:1110-5. 2004..We assessed the safety and effectiveness of the sirolimus-eluting stent (SES) in treating single de novo long lesions in small native coronary arteries compared to an identical bare metal stent (BMS)...
- Association between the risk of coronary artery disease in South Asians and a deletion polymorphism in glutathione S-transferase M1Michael H Wilson
Molecular Epidemiology Unit, Epidemiology and Health Services Research, University of Leeds, Leeds, UK
Biomarkers 8:43-50. 2003..1). The results of this study indicate that the GSTM1 null genotype is protective against both CAD and AMI. However, further study is required in order to elucidate the, as yet unexplained, mechanisms underlying this association...
- The E-selectin S128R polymorphism is not a risk factor for coronary artery disease in patients with diabetes mellitus type 2Georg Endler
Department of Medical and Chemical Laboratory Diagnostics, Medical School, University of Vienna, Waehringer Gurtel 18 20, A 1090 Vienna, Austria
Thromb Res 112:47-50. 2003..The impact of the S128R polymorphism on the development of diabetic coronary artery disease has not been investigated yet...
- A comprehensive linkage analysis for myocardial infarction and its related risk factorsUlrich Broeckel
Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Nat Genet 30:210-4. 2002..Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease...
- Mutation of MEF2A in an inherited disorder with features of coronary artery diseaseLejin Wang
Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
Science 302:1578-81. 2003..These results identify a pathogenic gene for a familial vascular disease with features of CAD and implicate the MEF2A signaling pathway in the pathogenesis of CAD/MI...
- Relationship between infectious burden, systemic inflammatory response, and risk of stable coronary artery disease: role of confounding and reference groupDietrich Rothenbacher
Department of Epidemiology, German Centre for Research on Ageing at the University of Heidelberg, Heidelberg, Germany
Atherosclerosis 170:339-45. 2003..We also investigated whether the choice of a larger reference group might affect the results, and whether or not seropositivity to multiple agents was associated with a systemic inflammatory response...
- A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD StudyElizabeth R Hauser
Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 75:436-47. 2004..These data provide initial areas of the human genome where further investigation may reveal susceptibility genes for early-onset CAD...
- Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery diseaseNicolas Lamblin
Centre Hospitalier Universitaire de Lille, Lille Cedex, France
J Am Coll Cardiol 40:43-8. 2002..Our hypothesis was that functional polymorphisms in matrix metalloproteinase (MMP) genes may act as susceptibility factors for the development of coronary aneurysms (CAs)...
- Low TGF-beta1 serum levels are a risk factor for atherosclerosis disease in ESRD patientsSergio Stefoni
Nephrology Dialysis and Renal Transplantation Unit, Department of Clinical Medicine and Applied Biotechnology, S Orsola University Hospital, Bologna, Italy
Kidney Int 61:324-35. 2002....
- Stress echocardiographyE Picano
CNR, Institute of Clinical Physiology, Pisa, Italy
Curr Pharm Des 11:2137-49. 2005....
- Health status predicts long-term outcome in outpatients with coronary diseaseJohn A Spertus
Mid America Heart Institute and University of Missouri Kansas City, Kansas City, MO 64111, USA
Circulation 106:43-9. 2002..Demonstrating that they independently predict mortality and hospitalizations among outpatients with coronary disease could emphasize their clinical value...
- The impact of renal insufficiency on patients' outcomes in emergent angioplasty for acute myocardial infarctionAbid R Assali
The Cardiac Catheterization Laboratories, Cardiology Department, Rabin Medical Center, 39 Jabotinsky Road, Petah Tikva 49100, Israel
Catheter Cardiovasc Interv 69:395-400. 2007..Objectives: The authors analyzed the outcomes of AMI patients with impaired renal function tests treated using primary percutaneous coronary intervention (PCI), to determine factors associated with increased mortality risk...
- Inflammatory markers, angiographic severity of coronary artery disease, and patient outcomeRishi Sukhija
Division of Cardiovascular Medicine, Central Arkansas Veterans Healthcare System, and University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Am J Cardiol 99:879-84. 2007..In conclusion, in patients hospitalized with chest pain, we found no association of serum levels of hs-CRP, IL-6, or TNF-alpha with coronary atherosclerotic burden or MACEs at 6 months after adjustment for traditional CAD risk factors...
- Frequency of slow coronary flow following successful stent implantation and effect of NitroprussideFlavio Airoldi
San Raffaele Hospital IRCCS, Milan, Italy
Am J Cardiol 99:916-20. 2007..In conclusion, the standardized protocol of intracoronary NTP administration succeeded in normalizing SCF in all patients with AMI but in only 5 of 9 patients with SVG stenosis. This latter subgroup requires other therapeutic strategies...
- [Life saving angioplasty of left main coronary artery in a high risk patient]Jacek Arkowski
Klinika Kardiologii AM, ul M Skłodowskiej Curie 66, 53 369 Wrocław
Kardiol Pol 64:1121-4; discussion 1125. 2006..In 9 month follow-up angiography there was no restenosis in LMCA. In patients to whom cardiac surgery presents very high risk, an angioplasty of LMCA can be life-saving, with good long term effects...
- Off-pump supraarterial decompression myotomy for myocardial bridgingMersa M Baryalei
Department of Thoracic and Cardiovascular Surgery, Georg August University Gottingen, Germany
Heart Surg Forum 8:E49-54; discussion E49-54. 2005..Surgery with cardiopulmonary bypass (CPB) is a therapeutic option with considerable risk. We hypothesized that off-pump supraarterial myotomy could be an effective treatment modality...
- Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndromeErdal Cavusoglu
Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA
Am J Cardiol 99:1364-8. 2007..34 ng/ml was 88% compared with 74% in those whose values were >20.34 ng/ml (p = 0.0249 by log-rank test). In conclusion, these data demonstrate that baseline MPO levels independently predict MI at 2 years in patients with ACS...
- Prognostic value of myocardial contrast echocardiography in patients presenting to hospital with acute chest pain and negative troponinParamjit Jeetley
Department of Cardiovascular Medicine, Northwick Park Hospital and Institute for Medical Education and Research, Harrow, Middlesex, United Kingdom
Am J Cardiol 99:1369-73. 2007..0003). In conclusion, stress MCE was superior to TIMI risk score and exercise electrocardiography in the assessment of risk in patients with suspected acute coronary syndrome, nondiagnostic electrocardiogram, and negative troponin...
- Procalcitonin in patients with acute coronary syndrome: correlation with high-sensitive C-reactive protein, prognosis and severity of coronary artery diseaseTunay Senturk
Department of Cardiology, Uludag University School of Medicine Bursa, Turkey
Acta Cardiol 62:135-41. 2007....
- The effect of electrical neurostimulation on collateral perfusion during acute coronary occlusionJessica de Vries
Dept of Cardiology, Thoraxcenter, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
BMC Cardiovasc Disord 7:18. 2007..We sought to study the effect of electrical neurostimulation on collateral perfusion...
- Predictors and prognosis for complex coronary lesions in patients with acute myocardial infarction: data from RICO surveyGilles Rioufol
Service de cardiologie, CHU Bocage, Bd Mal de Lattre de Tassigny, Dijon, France
Am Heart J 154:330-5. 2007..We aimed to investigate the determinants and outcomes of multiple complex lesions (MCLs) on coronary angiography in patients with an acute myocardial infarction...
- Hybrid coronary revascularization in high-risk patientsMelih Hulusi Us
Department of Cardiovascular Surgery, GATA Haydarpasa Training Hospital, 81080 Istanbul, Turkey
Tex Heart Inst J 33:458-62. 2006..Hybrid coronary revascularization enables complete revascularization and may be an alternative method of treating selected patients who have concomitant disease...
- In-hospital and nine-month outcome of treatment of coronary bifurcational lesions with sirolimus-eluting stentLei Ge
EMO Centro Cuore Columbus and San Raffaele Hospital, Milan, Italy Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
Am J Cardiol 95:757-60. 2005..4% vs 8.9%, p = 0.76), target vessel revascularization (5.4% vs 11.1%, p = 0.51), and cumulative major adverse cardiac events (18.9% vs 23.3%, p = 0.76) at 9 months...
- Progression of coronary artery calcium and occurrence of myocardial infarction in patients with and without diabetes mellitusPaolo Raggi
Tulane University School of Medicine, 1430 Tulane Ave, SL 48, New Orleans, LA 70112, USA
Hypertension 46:238-43. 2005....
- Role of NFY in Irradiation Induced Gene activationNadia Jahroudi; Fiscal Year: 2002..endothelial cells is thus a major cause of complications including, thrombus formation, premature coronary arteriosclerosis, and myocardial infarction, or fibrosis, that occur as a consequence of irradiation therapy...
- Determinants of arterial function in hypertensionIftikhar J Kullo; Fiscal Year: 2010..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
- Proteomic Markers of ArteriosclerosisIftikhar Kullo; Fiscal Year: 2008..unreadable] [unreadable]..
- Biomarkers of Peripheral Arterial DiseaseIftikhar Kullo; Fiscal Year: 2007..abstract_text> ..
- Functional Arterial Changes in AtherogenesisIftikhar Kullo; Fiscal Year: 2007..abstract_text> ..
- AtherothrombosisPeter Libby; Fiscal Year: 2005..This effort will hasten the translation of research discoveries to promote health of the heart and blood vessels at home and abroad. ..
- Inflammatory Mechanisms of AtherosclerosisPeter Libby; Fiscal Year: 2006..5. We will explore a putative functional role of a novel prostaglandin E2 receptor EP4 interacting protein (EPRAP) in endogenous anti-inflammatory pathways. ..
- Ventricular Size and Valve Calcification Measures by CTMatthew J Budoff; Fiscal Year: 2010..abstract_text> ..
- Cardiac MDCT for Early Triage of Patients with ACSUdo Hoffmann; Fiscal Year: 2008..abstract_text> ..
- Socioeconimic Patterning of Inflammation and HemostasisAna Diez Roux; Fiscal Year: 2007..The study will provide a unique opportunity to elucidate the links between socioeconomic factors, stress, inflammation and hemostasis in a large and diverse population-based sample. ..
- Inflammation, Procoagulation, and Plaque VulnerabilityBurton Sobel; Fiscal Year: 2005..abstract_text> ..
- Renin Angiotensin for Coronary Microvascular DysfunctionCarl Pepine; Fiscal Year: 2005....
- Pharmacogenetic Antiplatelet Strategies in CHD PatientsGlen Cooke; Fiscal Year: 2007..Such information will be paramount in the targeting of antiplatelet therapies and will be based on genomlc information (pharmacogenetics)...
- Outcomes of Sleep Disorders in Older MenElizabeth Barrett Connor; Fiscal Year: 2007..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
- Net Lifetime Health Effects of Alcohol Use & AbuseCURTIS ELLISON; Fiscal Year: 2007..The study will produce a unique dataset and will provide information that should improve our knowledge of the net effects of alcohol throughout adult life. ..
- BARI II - FIBRINOLYSIS AND COAGULATION COREBurton Sobel; Fiscal Year: 2006..The investigators further expect that this collaborative effort will translate into a new practical clinical paradigm that will be used for treatment of Type II diabetic patients. ..
- Opioid Prescribing Patterns in the U.S.Mark Pletcher; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Platelet Functional Genomics in Cardiovascular DiseaseMarlene Williams; Fiscal Year: 2006..By following these career goals, the candidate will eventually be able to ask pertinent questions applicable to the acute coronary syndrome and platelet function and become an independent clinical investigator. ..
- Serum Protemic Patterns Associated With AtherosclerosisMark Pletcher; Fiscal Year: 2006....
- Pharmacogenetics of the Statin ResponseERNST SCHAEFER; Fiscal Year: 2006..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
- Mesenchymal Stem Cells for Myocardial InfarctionRobert Kloner; Fiscal Year: 2006..abstract_text> ..
- TOSCA-2 An Angiographic Substudy of the Occluded Arter*Vladimir Dzavik; Fiscal Year: 2004..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
- Biochemical Heterogeneity in Morbidly Obese Women in the WHI Observational StudyRachel Mackey; Fiscal Year: 2008..This will be the first epidemiology study to specifically focus on morbidy obesity Class III unselected for weight reduction, i.e. bariatric surgery, in black and white women. ..
- GENCAC - Framingham Field CenterCURTIS ELLISON; Fiscal Year: 2004..abstract_text> ..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..abstract_text> ..
- COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSESRobert Kloner; Fiscal Year: 2003....
- Endogenous/Exogenous Sex Hormones & CHD Risk FactorsElizabeth Barrett Connor; Fiscal Year: 2003..These observations may aid in deciding whether individual women should use HRT and, if so, which regimen would provide the most benefit with the least risk. ..
- CVD Predictors of Cognitive Function Trajectory over 20 YearsElizabeth L Barrett Connor; Fiscal Year: 2010..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
- Biologic Ventricular Assist DeviceRobert Kloner; Fiscal Year: 2004..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
- NEIGHBORHOOD ENVIRONMENTS AND CARDIOVASCULAR DISEASEAna Diez Roux; Fiscal Year: 2002..The investigators point ut that the proposed study builds on existing cohort studies of cardiovascular disease to explore hypotheses relevant to understanding the factors contributing to SES differences in CVD risk. ..
- GENDER DIFFERENCES IN OSTEOPOROSISElizabeth Barrett Connor; Fiscal Year: 2002....
- CORONARY CALCIFICATION PROGRESSION STUDYJOHN CROUSE; Fiscal Year: 2001..They point out that pilot data support the feasibility and likely informativeness of this study. ..
- Carotid Atherosclerosis (MRI) Progression Study (CAMP)JOHN CROUSE; Fiscal Year: 2008..abstract_text> ..
- MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCYERNST SCHAEFER; Fiscal Year: 2009..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
- HYPERGEN-BOSTON UNIVERSITY/FRAMINGHAM FIELD CENTERCURTIS ELLISON; Fiscal Year: 2004..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
- Fatty Acids and Cardiovascular HealthDariush Mozaffarian; Fiscal Year: 2007..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- New Cardiac Surgery Programs: Patients, Outcomes, AccessFRANCES LUCAS; Fiscal Year: 2008..procedures or result in an overall increase in the population-based rates of care, including CABG and total revascularization (either CABG or percutaneous coronary interventions) as additional capacity is brought online? ..
- Long Term Effects of Subclinical CAD on Cardiac FunctionRobert Detrano; Fiscal Year: 2007..The proposed research will determine the presence and extent of a link between sub-clinical atherosclerosis and its progression and subsequent cardiac function. [unreadable] [unreadable]..
- Novel Risk Factors for Chronic Kidney DiseaseRonald Klein; Fiscal Year: 2008..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
- INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGESIRA A TABAS; Fiscal Year: 2010..abstract_text> ..
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Jay Mukamal; Fiscal Year: 2010..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- Discharge Planning and Telehealth for Post CABG EldersRuth Kleinpell; Fiscal Year: 2009....
- Mentored Career Development in Patient Oriented ResearchDaniel Rader; Fiscal Year: 2006..abstract_text> ..
- Pathways for the Inflammatory Damage of BiomoleculesJay Heinecke; Fiscal Year: 2006..abstract_text> ..
- BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMESMary McDermott; Fiscal Year: 2004....
- Targeting Apolipoprotein E4-related NeuropathologyRobert Mahley; Fiscal Year: 2004..Ultimately, it will be our goal to take "hits" to lead compounds that may give rise to a drug that prevents or retards apoE4-related neuropathology. ..
- CLINICAL INVESTIGATOR TRAINING ENHANCEMENT: CITE PROGRAMKurt Kroenke; Fiscal Year: 2004..abstract_text> ..
- TRAINING IN TISSUE ENGINEERING & IMPLANT SCIENCEJoachim Kohn; Fiscal Year: 2004..abstract_text> ..
- MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSISDaniel Rader; Fiscal Year: 2004..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..
- SES, health behaviors and CVD among Vietnam-era-TwinsJeanne McCaffery; Fiscal Year: 2005..The primary method of analysis will be twin structural equation modeling. ..
- Conference on Cellular Biology of AtherosclerosisIra Tabas; Fiscal Year: 2005....
- Multi-Ethnic Study of Atherosclerosis-Eye StudyRonald Klein; Fiscal Year: 2005..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
- Microvascular - Macrovascular Disease in Type 2 DiabetesRonald Klein; Fiscal Year: 2005....
- Lipid Testing /Treatment in Older MI PatientsJoAnne Foody; Fiscal Year: 2005..This work will ultimately improve care for the elderly patient with cardiovascular disease. ..
- GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVESStephen Turner; Fiscal Year: 2006....
- Genetic Predictors of Comorbid Depressive Symptoms + CADJeanne McCaffery; Fiscal Year: 2005....
- HOSTILITY, MARITAL INTERACTION AND HEALTH IN AGINGTimothy Smith; Fiscal Year: 2004..g., fluid and crystallized intelligence). The long-term goal of the research is to identify potentially modifiable determinants of cardiovascular risk, marital adjustment, and cognitive aging in adulthood. ..
- RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITYRonald Klein; Fiscal Year: 2002..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
- Cardiovascular-Oxytocin Links in Social InteractionTimothy Smith; Fiscal Year: 2005..Explication of the psychobiology of social support and related psychosocial risk factors in personal relationships could guide the refinement of risk reducing, preventive interventions. ..
- Non-Invasive Localization of Vulnerable PlaquesCynthia McCollough; Fiscal Year: 2009....
- GENETIC DETERMINATION OF ALLOGRAFT VASCULOPATHYRaymond Benza; Fiscal Year: 2002..If his faculty mentor were to leave the institution, a new mentor will be appointed and his continued development toward becoming a independent physician scientist supported and encouraged. ..
- Conference on Angiogenesis in Cancer and Other DiseasesRakesh Jain; Fiscal Year: 2002..The meeting's synthesis of available information will be particularly thought-provoking for students and post- doctoral fellows. ..
- Lipoproteins, HIV, and Antiretroviral Therapy in SMARTDaniel Duprez; Fiscal Year: 2008..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
- Mesenchymal Stem Cells and Ventricular RemodelingJoshua Hare; Fiscal Year: 2004..Furthermore, these noninvasive techniques will be immediately transferable to human clinical trials. ..
- PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISMPaul Bray; Fiscal Year: 2001..These studies will enhance our understanding of the role of integrin biology (especially in platelets), and help to achieve our long-term goal of implementing a more rational anti-thrombotic therapy. ..
- OXIDATIVE STRESS IN HEART FAILURE: MECHANISMSJoshua Hare; Fiscal Year: 2008..Finally, the present studies in 3 highly relevant animal models will provide mechanistic insights complementary to those expected from ongoing clinical trials designed to test the utility of XO inhibitors in human HF therapy. ..
- Behavioral Ecology and Hostility & Cardiac ANS ControlRichard Sloan; Fiscal Year: 2007..Thus, we expect to demonstrate how personality traits, in combination with social interactions and behavior throughout the day, drive the risk of CHD through an autonomic mechanism. ..
- Cytokine-induced depression & the serotonin transporterRichard Sloan; Fiscal Year: 2007..unreadable] [unreadable]..
- HOSTILITY REDUCTION AND AUTONOMIC CONTROL OF THE HEARTRichard Sloan; Fiscal Year: 2004....
- GENCAC - North Carolina Field CenterLynne Wagenknecht; Fiscal Year: 2004..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
- CT EVALUATION OF DIABETIC TIBIAL ARTERY CALCIFICATIONRAUL GUZMAN; Fiscal Year: 2006..Our ultimate goal is to prevent the marco-vascular complications of diabetes, and to decrease the incidence of lower extremity amputation that causes disability in our patients. ..
- Integrative Biology of Tumor MetastasisRakesh Jain; Fiscal Year: 2009..Finally, we have the resources and the clinical collaborators in place to initiate a clinical trial based on our findings, as attested by our ongoing trial using a VEGF-specific antibody. ..
- Anti-Angiogenesis/Drugs in Tumors--Bench /Bedside & BackRakesh Jain; Fiscal Year: 2005..Attendance at this conference will provide an excellent opportunity for young investigators working on cancer to educate and familiarize themselves with the field of angiogenesis and the complexities of the system. ..
- WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEASRonald Klein; Fiscal Year: 2002....
- Postmenopause CHD risk: Platelet genes & hormone therapyPaul Bray; Fiscal Year: 2006..abstract_text> ..
- GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASISLynne Wagenknecht; Fiscal Year: 2009..abstract_text> ..