coronary arteriosclerosis

Summary

Summary: Thickening and loss of elasticity of the coronary arteries, leading to progressive insufficiency of the arteries (CORONARY DISEASE).

Top Publications

  1. ncbi Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-up
    Emmanouil S Brilakis
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 26:137-44. 2005
  2. ncbi Coronary artery calcification and family history of premature coronary heart disease: sibling history is more strongly associated than parental history
    Khurram Nasir
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circulation 110:2150-6. 2004
  3. ncbi Atherogenic lipoprotein particles in atherosclerosis
    Rafael Carmena
    Department of Endocrinology and Nutrition, Facultad de Medicina y Hospital Clinico Universitario, Valencia, Spain
    Circulation 109:III2-7. 2004
  4. ncbi Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice
    Kazuhiko Inoue
    Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565 8565 Osaka, Japan
    Circ Res 97:176-84. 2005
  5. ncbi Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial
    David D Waters
    Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
    JAMA 288:2432-40. 2002
  6. ncbi Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
  7. ncbi Prognostic value of coronary vascular endothelial dysfunction
    Julian P J Halcox
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circulation 106:653-8. 2002
  8. ncbi T1 and M1 polymorphism in glutathione S-transferase gene and coronary artery disease in North Indian population
    K M Girisha
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Med Sci 58:520-6. 2004
  9. ncbi Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals
    Philip Greenland
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill 90502, USA
    JAMA 291:210-5. 2004
  10. ncbi Association of hypoadiponectinemia with coronary artery disease in men
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Arterioscler Thromb Vasc Biol 23:85-9. 2003

Research Grants

  1. Role of NFY in Irradiation Induced Gene activation
    Nadia Jahroudi; Fiscal Year: 2002
  2. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
  3. Proteomic Markers of Arteriosclerosis
    Iftikhar Kullo; Fiscal Year: 2008
  4. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
  5. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
  6. Atherothrombosis
    Peter Libby; Fiscal Year: 2005
  7. Inflammatory Mechanisms of Atherosclerosis
    Peter Libby; Fiscal Year: 2006
  8. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
  9. Cardiac MDCT for Early Triage of Patients with ACS
    Udo Hoffmann; Fiscal Year: 2008
  10. Socioeconimic Patterning of Inflammation and Hemostasis
    Ana Diez Roux; Fiscal Year: 2007

Detail Information

Publications210 found, 100 shown here

  1. ncbi Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-up
    Emmanouil S Brilakis
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 26:137-44. 2005
    ..We aimed to evaluate the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with coronary artery disease (CAD) risk factors, with the severity of angiographic CAD, and with the incidence of major adverse events...
  2. ncbi Coronary artery calcification and family history of premature coronary heart disease: sibling history is more strongly associated than parental history
    Khurram Nasir
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circulation 110:2150-6. 2004
    ....
  3. ncbi Atherogenic lipoprotein particles in atherosclerosis
    Rafael Carmena
    Department of Endocrinology and Nutrition, Facultad de Medicina y Hospital Clinico Universitario, Valencia, Spain
    Circulation 109:III2-7. 2004
    ..Ultimately, better understanding of the roles of these lipid particles and subfractions in the initiation and progression of atherosclerosis may affect treatment decisions...
  4. ncbi Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice
    Kazuhiko Inoue
    Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565 8565 Osaka, Japan
    Circ Res 97:176-84. 2005
    ....
  5. ncbi Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial
    David D Waters
    Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
    JAMA 288:2432-40. 2002
    ..Hormone replacement therapy (HRT) and antioxidant vitamins are widely used for secondary prevention in postmenopausal women with coronary disease, but no clinical trials have demonstrated benefit to support their use...
  6. ncbi Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
    ..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
  7. ncbi Prognostic value of coronary vascular endothelial dysfunction
    Julian P J Halcox
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circulation 106:653-8. 2002
    ....
  8. ncbi T1 and M1 polymorphism in glutathione S-transferase gene and coronary artery disease in North Indian population
    K M Girisha
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Med Sci 58:520-6. 2004
    ..In the present study the contribution of the polymorphism in the glutathione S-transferase gene to the development of coronary artery disease has been investigated...
  9. ncbi Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals
    Philip Greenland
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill 90502, USA
    JAMA 291:210-5. 2004
    ..Although the Framingham Risk Score (FRS) is often recommended for this, it has been suggested that risk assessment may be improved by additional tests such as coronary artery calcium scoring (CACS)...
  10. ncbi Association of hypoadiponectinemia with coronary artery disease in men
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Arterioscler Thromb Vasc Biol 23:85-9. 2003
    ..This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD)...
  11. pmc KLOTHO allele status and the risk of early-onset occult coronary artery disease
    Dan E Arking
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 72:1154-61. 2003
    ..Modifiable risk factors, including hypertension, smoking status, and HDL-C level, appear to influence the risk imposed by this allele...
  12. ncbi Coronary artery, aortic wall, and valvular calcification in nondialyzed individuals with type 2 diabetes and renal disease
    Raffi Merjanian
    Division of Nephrology and Hypertension, Department of Pediatrics, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90502, USA
    Kidney Int 64:263-71. 2003
    ..We undertook this study to test the hypothesis that vascular and valvular calcification begins and is often severe long before diabetic renal disease progresses to ESRD...
  13. ncbi Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk
    Serena Masetti
    Sant Anna School, Pisa, Italy
    J Mol Med (Berl) 81:488-94. 2003
    ..These observations suggest that GST-null genotypes strengthen the effect of smoking on CAD risk by modulating the detoxification of genotoxic atherogens...
  14. ncbi Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study
    Eric A Miller
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Atherosclerosis 171:265-72. 2003
    ..The results of this study provide some limited evidence that GSTM1 and GSTT1 polymorphisms modify the effect of smoking on inflammation, hemostasis, and endothelial function...
  15. ncbi Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries
    J Eduardo Sousa
    Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil
    Circulation 107:381-3. 2003
    ..We sought to evaluate the angiographic, intravascular ultrasound (IVUS), and clinical outcomes of patients treated with sirolimus-eluting stents 2 years after implantation...
  16. pmc E-selectin S128R polymorphism and severe coronary artery disease in Arabs
    Khaled K Abu-Amero
    Genetics Department, King Faisal Specialist Hospital and Research Centre MBC 03, P, O, Box 3354, Riyadh 11211, Saudi Arabia
    BMC Med Genet 7:52. 2006
    ..The E-selectin p. S128R (g. A561C) polymorphism has been associated with the presence of angiographic coronary artery disease (CAD) in some populations, but no data is currently available on its association with CAD in Arabs...
  17. pmc Efficacy of case method learning in general practice for secondary prevention in patients with coronary artery disease: randomised controlled study
    Anna Kiessling
    Centre for Clinical Education, Danderyd University Hospital and Karolinska Institute, SE 182 88 Stockholm, Sweden
    BMJ 325:877-80. 2002
    ..To study the efficacy of case method learning, for general practitioners, on patients' lipid concentrations in the secondary prevention of coronary artery disease...
  18. ncbi Prognostic significance of plasma concentrations of transforming growth factor-beta in patients with coronary artery disease
    Hideki Tashiro
    Division of Cardiology, St Mary s Hospital, Kurume, Japan
    Coron Artery Dis 13:139-43. 2002
    ..In this study, we examined whether those alterations in plasma levels of cytokines have a prognostic significance in patients with CAD...
  19. ncbi Human epicardial adipose tissue is a source of inflammatory mediators
    Tomasz Mazurek
    Department of Surgery, Thomas Jefferson University, Suite 623, 1025 Walnut St, Philadelphia, PA 19107, USA
    Circulation 108:2460-6. 2003
    ..In this study, we sought to compare expression of inflammatory mediators in epicardial and subcutaneous adipose stores in patients with critical CAD...
  20. ncbi Adipokines: molecular links between obesity and atheroslcerosis
    David C W Lau
    Department of Medicine, Julia McFarlane Diabetes Research Center, University of Calgary, Calgary, Canada
    Am J Physiol Heart Circ Physiol 288:H2031-41. 2005
    ..Finally, we will discuss how these new insights may provide us with innovative therapeutic strategies to improve cardiovascular health...
  21. ncbi Echolucent carotid plaques predict future coronary events in patients with coronary artery disease
    Osamu Honda
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Am Coll Cardiol 43:1177-84. 2004
    ..The purpose of this study was to examine whether echolucent carotid plaques predict future coronary events in patients with clinically stable coronary artery disease (CAD)...
  22. ncbi Increased Th1 activity in patients with coronary artery disease
    Juliano L Fernandes
    Heart Institute InCor, University of Sao Paulo Medical School, Brazil
    Cytokine 26:131-7. 2004
    ....
  23. ncbi Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project
    Allen J Taylor
    Department of Medicine, Cardiology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
    J Am Coll Cardiol 46:807-14. 2005
    ..We sought to examine the independent predictive value of coronary artery calcium detection for coronary outcomes in a non-referred cohort of healthy men and women ages 40 to 50 years...
  24. ncbi Predictive value of associations between carotid and coronary artery disease in patients with acute coronary syndromes
    Roman Komorovsky
    Cardiovascular Research Foundation, Department of Angiology, S Giacomo Hospital, Castelfranco Veneto, Italy
    Am J Cardiol 95:116-9. 2005
    ..In treatment-stratified Cox's proportional hazards regression analysis, hard carotid plaques and coronary lesions of complex morphology were found to be independent predictors of future cardiac events...
  25. ncbi Getting to the heart of social support: a qualitative analysis of the types of instrumental support that are most helpful in motivating cardiac risk factor modification
    Carla Boutin-Foster
    The Joan and Sanford I Weill Medical College, Cornell University, New York, NY 10021, USA
    Heart Lung 34:22-9. 2005
    ..This study evaluates the types of instrumental social support that are perceived by patients with coronary artery disease as being most helpful to health behavior modification...
  26. ncbi Cardiovascular risk scores and the presence of subclinical coronary artery atherosclerosis in women with systemic lupus erythematosus
    C P Chung
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Lupus 15:562-9. 2006
    ..Measurement of coronary calcification may add information to identify asymptomatic women with lupus who might benefit from aggressive preventive measures...
  27. ncbi Associations of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery disease
    John R Crouse
    Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 106:2061-6. 2002
    ..Few studies have explored the association of risk factors with progression of IMT, and none have evaluated their associations with IMT progression specifically in patients with and without CAD...
  28. ncbi Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 107:671-4. 2003
    ..The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue...
  29. ncbi Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Health Science and Management, Yonsei University, Seoul 120 752, South Korea
    Hum Genet 111:128-35. 2002
    ..The results of this study also indicated that multifactorial inheritance was supported more strongly than Mendelian inheritance alone. Our findings may have implications for attempts to identify new homocysteine susceptible genes...
  30. ncbi Paclitaxel coating reduces in-stent intimal hyperplasia in human coronary arteries: a serial volumetric intravascular ultrasound analysis from the Asian Paclitaxel-Eluting Stent Clinical Trial (ASPECT)
    Myeong Ki Hong
    Department of Medicine, University of Ulsan College of Medicine, Songpa Gu, Seoul, Korea
    Circulation 107:517-20. 2003
    ..The aim of this study was to use serial volumetric intravascular ultrasound (IVUS) to evaluate the effect of a paclitaxel coating on in-stent intimal hyperplasia (IH)...
  31. ncbi Effects of exercise and diet on chronic disease
    Christian K Roberts
    Dept of Physiological Science, University of California Los Angeles, 4101 Life Sciences Bldg, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
    J Appl Physiol (1985) 98:3-30. 2005
    ....
  32. ncbi Usefulness of insulin resistance measured by homeostasis model assessment in predicting restenosis after coronary stent placement in nondiabetic patients
    Makoto Sekiguchi
    Department of Medicine and Biological Science, Graduate School of Medicine, Gunma University, Maebashi, Japan
    Am J Cardiol 93:920-2. 2004
    ..Our findings suggest that insulin resistance measured by the homeostasis model assessment predicts restenosis after coronary stent placement in nondiabetic patients...
  33. ncbi A tertiary care hospital-based study of conventional risk factors including lipid profile in proven coronary artery disease
    Pravin K Goel
    Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow
    Indian Heart J 55:234-40. 2003
    ..Most data on lipid levels in Indians have been obtained from studies on migrant Asian Indians. There are insufficient data on lipid profile and other conventional risk factors in Indian patients living within India...
  34. ncbi Drug-eluting stents: clinical experiences and perspectives
    E Grube
    Heart Center Siegburg, Siegburg, Germany, Italy
    Minerva Cardioangiol 50:469-73. 2002
    ..Nevertheless, we need more trials and an agreement of definitions in order to evaluate this treatment concept and eliminate unwanted side-effects...
  35. ncbi Significant reduction in restenosis after the use of sirolimus-eluting stents in the treatment of chronic total occlusions
    Angela Hoye
    Department of Interventional Cardiology, Erasmus MC, Rotterdam, The Netherlands
    J Am Coll Cardiol 43:1954-8. 2004
    ..The aim of this study was to assess sirolimus-eluting stent (SES) implantation for the treatment of chronic total coronary occlusions (CTO)...
  36. ncbi Undertreatment of hyperlipidemia in patients with coronary artery disease and heart failure
    Carla A Sueta
    Medical Review of North Carolina, Cary, North Carolina 27511, USA
    J Card Fail 9:36-41. 2003
    ..We examined the frequency of lipid assessment and prescription of lipid-lowering agents in outpatients with combined CAD+HF compared with patients with CAD alone...
  37. ncbi Clinical implications of carotid artery remodeling in acute coronary syndrome: ultrasonographic assessment of positive remodeling
    Masaya Kato
    Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan
    J Am Coll Cardiol 42:1026-32. 2003
    ..We investigated the relationship between ultrasonographic features of the carotid artery and the angiographic features of coronary plaques in acute coronary syndrome (ACS)...
  38. ncbi Correlation of coronary arterial remodeling determined by intravascular ultrasound with angiographic diameter reduction of 20% to 60%
    Makoto Hirose
    Cardiovascular Research Foundation, New York, NY 10021, USA
    Am J Cardiol 92:141-5. 2003
    ..7) were similar. Negative remodeling is frequently observed in lesions with intermediate stenosis. This suggests that negative remodeling occurs early in lesion formation...
  39. ncbi Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis
    Natalie Khuseyinova
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Atherosclerosis 182:181-8. 2005
    ..12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD...
  40. pmc Transcription factor MEF2A mutations in patients with coronary artery disease
    M R Krishna Bhagavatula
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Mol Genet 13:3181-8. 2004
    ..93%) may carry mutations in MEF2A, although further definition of the prevalence of MEF2A mutations is warranted...
  41. ncbi Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis
    Muredach P Reilly
    Cardiovascular Division and Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 110:803-9. 2004
    ....
  42. ncbi Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors
    Cecilia P Chung
    Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Arthritis Rheum 52:3045-53. 2005
    ..To compare the prevalence and severity of coronary-artery atherosclerosis in patients with early and established rheumatoid arthritis (RA) and controls...
  43. ncbi Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study
    Peter H Stone
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:438-44. 2003
    ..The endothelium controls local arterial responses by transduction of shear stress. Characterization of endothelial shear stress (ESS) may allow for prediction of progression of atherosclerosis and in-stent restenosis...
  44. ncbi Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease
    Gianluca Iacobellis
    Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy
    Cytokine 29:251-5. 2005
    ..Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin...
  45. ncbi Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjects
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 95:1025-32. 2005
    ....
  46. pmc Association of increased carotid intima-media thickness with the extent of coronary artery disease
    A Kablak-Ziembicka
    Department of Cardiac and Vascular Diseases, The John Paul II Hospital, Krakow, Poland
    Heart 90:1286-90. 2004
    ..The coexistence of severe extracranial atherosclerosis in patients with CAD was also analysed...
  47. ncbi Risk factors for acute myocardial infarction in a rural population of central India: a hospital-based case-control study
    Samir S Patil
    Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442102, Maharashtra, India
    Natl Med J India 17:189-94. 2004
    ..We conducted a prospective case-control study to determine the risk factors for acute myocardial infarction in a rural population of central India...
  48. ncbi Coronary artery calcium score, risk factors, and incident coronary heart disease events
    Timothy S Church
    The Cooper Institute, Dallas, TX 75230, United States
    Atherosclerosis 190:224-31. 2007
    ..We sought to identify a potential threshold of coronary artery calcium for clinical use and examine the predictive power of coronary artery calcium in individuals categorized using conventional coronary heart disease risk assessment...
  49. ncbi Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease
    Tetsuro Miyazaki
    Department of Cardiology, Juntendo University School of Medicine, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Atherosclerosis 179:139-45. 2005
    ..However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined...
  50. ncbi Markers of endothelial dysfunction in the prediction of coronary artery disease in type 1 diabetes. The Pittsburgh Epidemiology of Diabetes Complications Study
    Tina Costacou
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Diabetes Complications 19:183-93. 2005
    ..13, 95% Cl=1.03-1.24; HRs are per standard deviation increase) but not hard CAD. Study results suggest that E-selectin may enhance CAD prediction beyond traditional risk factors or markers of oxidative stress in Type 1 diabetes...
  51. ncbi Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development
    A H Schoneveld
    Department of Cardiology, Experimental Cardiology Laboratory, UMC, Heidelberglaan 100, Room G02 523, 3584 CX Utrecht, The Netherlands
    Cardiovasc Res 66:162-9. 2005
    ..Here, we determined whether Tlr2 stimulation promotes pro-inflammatory cytokine/chemokine production in vitro and augments neointima formation and development of atherosclerotic plaques in vivo...
  52. ncbi Added value of attenuation-corrected Tc-99m tetrofosmin SPECT for the detection of myocardial viability: comparison with FDG SPECT
    Riemer H J A Slart
    Department of Nuclear Medicine, Groningen University Medical Center, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    J Nucl Cardiol 11:689-96. 2004
    ..The aim of this study was to evaluate the value of attenuation correction of technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging for the detection of myocardial viability...
  53. ncbi Do longer delays for coronary artery bypass surgery contribute to preoperative mortality in less urgent patients?
    Boris G Sobolev
    Department of Health Care and Epidemiology, The University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada
    Med Care 44:680-6. 2006
    ..We evaluated whether longer delays contribute to the probability of death before surgery among patients prioritized into the less urgent category...
  54. ncbi Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 352:29-38. 2005
    ..Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression...
  55. ncbi Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis
    Eleonora Simeoni
    Division of Cardiology, University of Lausanne, Switzerland
    Eur Heart J 25:1438-46. 2004
    ..In a case-control study, we explored relations between these polymorphisms and coronary artery disease (CAD), with respect to angiographic abnormalities and acute coronary syndromes (ACS)...
  56. ncbi Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
    Hum Genet 117:444-51. 2005
    ..This study replicates the involvement of USF1 in FCHL and related lipid traits in a family sample not ascertained for FCHL...
  57. ncbi CT measurement of coronary calcium mass: impact on global cardiac risk assessment
    Christoph R Becker
    Department of Clinical Radiology, Ludwig Maximilians University Hospital Munich, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Eur Radiol 15:96-101. 2005
    ..The coronary calcium mass and age-related scoring system may have impact on the reassignment of patients with an intermediate Framingham risk to a lower or higher risk group...
  58. ncbi Genetic susceptibility to coronary artery disease: from promise to progress
    Hugh Watkins
    Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 9DU, UK
    Nat Rev Genet 7:163-73. 2006
    ..Recent findings particularly highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer...
  59. pmc Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease
    H L Geng
    Department of Laboratory Diagnosis, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Clin Exp Immunol 143:269-73. 2006
    ..was to investigate the expression of TLR4 on peripheral-blood mononuclear cells (PBMCs) in patients with coronary arteriosclerosis disease (CAD)...
  60. pmc A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Am J Hum Genet 77:1011-20. 2005
    ..The exclusion of a common locus that increases risk of CAD to siblings by >50% has important implications for strategies for further defining the genetic basis of CAD...
  61. ncbi Collateral-flow measurements in humans by myocardial contrast echocardiography: validation of coronary pressure-derived collateral-flow assessment
    Rolf Vogel
    Department of Cardiology, University Hospital Bern, CH 3010 Bern, Switzerland
    Eur Heart J 27:157-65. 2006
    ..The aims of this human study are (i) to test whether measurements of collateral-derived MBF by MCE are feasible during elective angioplasty and (ii) to validate the concept of pressure-derived collateral-flow assessment...
  62. ncbi Hormone therapy, lipoprotein subclasses, and coronary calcification: the Healthy Women Study
    Rachel H Mackey
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Arch Intern Med 165:510-5. 2005
    ..To test this hypothesis, we evaluated differences in coronary calcification, lipids, and lipoprotein subclasses among HT users and nonusers in a longitudinal study of the menopause...
  63. ncbi Glutathione S-transferase gene polymorphism as a susceptibility factor in smoking-related coronary artery disease
    Lulufer Tamer
    Mersin University Medical Faculty, Department of Biochemistry, 33079, Mersin Turkey
    Basic Res Cardiol 99:223-9. 2004
    ..20 (1.37 - 7.45)) were at a higher risk for developing coronary heart disease. In conclusion, the finding of a significant association between GSTM1 and T1 with smoking status may influence cardiovascular disease via DNA damage...
  64. pmc Safety and cardiac chronotropic responsiveness to the early injection of atropine during dobutamine stress echocardiography in the elderly
    J M Tsutsui
    Echocardiography Laboratory, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Heart 91:1563-7. 2005
    ..To determine the safety and cardiac chronotropic responsiveness to early atropine dobutamine stress echocardiography (DSE) in the elderly...
  65. ncbi Coronary artery disease in Saudi Arabia
    Mansour M Al-Nozha
    Taiba University, PO Box 344, Madina Al Munawarah, Kingdom of Saudi Arabia
    Saudi Med J 25:1165-71. 2004
    ..Further, to determine the prevalence and clinical pattern of the major modifiable risk factors for CAD among the same population. This work is part of a major national study on CAD in Saudis Study (CADISS)...
  66. ncbi Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomography
    Daniel S Berman
    Department of Imaging, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Am Coll Cardiol 44:923-30. 2004
    ....
  67. ncbi Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians
    Lu Fang
    Johns Hopkins Singapore National Heart Centre Vascular Biology Program, National University of Singapore
    Indian J Med Res 121:92-9. 2005
    ....
  68. ncbi TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions
    Eberhard Grube
    Department of Cardiology Angiology, Heart Center Siegburg, Siegburg, Germany
    Circulation 107:38-42. 2003
    ..The TAXUS I trial was the first in-human experience evaluating safety and feasibility of the TAXUS NIRx stent system compared with bare NIR stents (control) (Boston Scientific Corp) for treatment of coronary lesions...
  69. ncbi Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions
    Antonio Colombo
    Ospedale San Raffaele, Milano, Italy
    Circulation 108:788-94. 2003
    ..Early clinical studies demonstrated the feasibility of local paclitaxel delivery in reducing restenosis after treatment of de novo coronary lesions in small patient populations...
  70. ncbi Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19004 6160, USA
    Atherosclerosis 173:69-78. 2004
    ..We present analytic approaches that are likely to provide consistent results and recommend the use of at least two distinct multivariable methods...
  71. ncbi Significance of plasma nitric oxide/endothelial-1 ratio for prediction of coronary artery disease
    Akira Kurita
    Department of Biomedical Engineering and Internal Medicine, National Defensse Medical College, Saitma, Japan
    Angiology 56:259-64. 2005
    ..The present results suggest that plasma NO/ET-1 ratio is a useful biological marker for predicting CAD...
  72. ncbi Safety and efficacy of bariatric surgery in patients with coronary artery disease
    Francisco Lopez-Jimenez
    Department of Internal Medicine and Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:1157-62. 2005
    ..To determine the safety and efficacy of bariatric surgery in obese patients with documented coronary artery disease (CAD)...
  73. ncbi In vivo quantitative tissue characterization of human coronary arterial plaques by use of integrated backscatter intravascular ultrasound and comparison with angioscopic findings
    Masanori Kawasaki
    Second Department of Internal Medicine, Gifu University School of Medicine, Japan
    Circulation 105:2487-92. 2002
    ..The purpose of the present study was to define whether integrated backscatter (IB) combined with conventional intravascular ultrasound (IVUS) makes tissue characterization of coronary arterial plaques possible...
  74. ncbi The influence of left ventricular hypertrophy on survival in patients with coronary artery disease: do race and gender matter?
    Mark A East
    Outcomes Research and Assessment Group, The Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 41:949-54. 2003
    ..We sought to determine the overall prognostic importance of left ventricular hypertrophy (LVH) among patients with coronary artery disease (CAD), as well as to determine whether this risk varies as a function of race or gender...
  75. ncbi Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery Lesions) trial
    Patrick W Serruys
    Thoraxcentre, Rotterdam, The Netherlands
    Circulation 106:798-803. 2002
    ..The goal of this intravascular ultrasound investigation was to provide a more detailed morphological analysis of the local biological effects of the implantation of a sirolimus-eluting stent compared with an uncoated stent...
  76. ncbi Coronary artery calcium scanning: Clinical paradigms for cardiac risk assessment and treatment
    Harvey S Hecht
    Lenox Hill Heart and Vascular Institute, New York, NY 10021, USA
    Am Heart J 151:1139-46. 2006
    ..Physician awareness of this technology and its appropriate uses and limitations is crucial to appropriate use...
  77. ncbi Role of surrogate markers in assessing patients with diabetes mellitus and the metabolic syndrome and in evaluating lipid-lowering therapy
    Venkataraman Rajaram
    Rush University Medical Center, Chicago, Illinois, USA
    Am J Cardiol 93:32C-48C. 2004
    ..Thus, surrogate markers may not only help improve individual patient outcomes, they also may help direct scarce medical resources to maximize medical benefits, improve overall medical care, and minimize costs and untoward side effects...
  78. ncbi The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries (C-SIRIUS)
    Erick Schampaert
    Hopital du Sacre Coeur de Montreal, 5400 Bl Gouin O, Montreal, Quebec, Canada H4J 1C5
    J Am Coll Cardiol 43:1110-5. 2004
    ..We assessed the safety and effectiveness of the sirolimus-eluting stent (SES) in treating single de novo long lesions in small native coronary arteries compared to an identical bare metal stent (BMS)...
  79. ncbi Association between the risk of coronary artery disease in South Asians and a deletion polymorphism in glutathione S-transferase M1
    Michael H Wilson
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, University of Leeds, Leeds, UK
    Biomarkers 8:43-50. 2003
    ..1). The results of this study indicate that the GSTM1 null genotype is protective against both CAD and AMI. However, further study is required in order to elucidate the, as yet unexplained, mechanisms underlying this association...
  80. ncbi The E-selectin S128R polymorphism is not a risk factor for coronary artery disease in patients with diabetes mellitus type 2
    Georg Endler
    Department of Medical and Chemical Laboratory Diagnostics, Medical School, University of Vienna, Waehringer Gurtel 18 20, A 1090 Vienna, Austria
    Thromb Res 112:47-50. 2003
    ..The impact of the S128R polymorphism on the development of diabetic coronary artery disease has not been investigated yet...
  81. ncbi A comprehensive linkage analysis for myocardial infarction and its related risk factors
    Ulrich Broeckel
    Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Genet 30:210-4. 2002
    ..Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease...
  82. pmc Mutation of MEF2A in an inherited disorder with features of coronary artery disease
    Lejin Wang
    Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Science 302:1578-81. 2003
    ..These results identify a pathogenic gene for a familial vascular disease with features of CAD and implicate the MEF2A signaling pathway in the pathogenesis of CAD/MI...
  83. ncbi Relationship between infectious burden, systemic inflammatory response, and risk of stable coronary artery disease: role of confounding and reference group
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing at the University of Heidelberg, Heidelberg, Germany
    Atherosclerosis 170:339-45. 2003
    ..We also investigated whether the choice of a larger reference group might affect the results, and whether or not seropositivity to multiple agents was associated with a systemic inflammatory response...
  84. pmc A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study
    Elizabeth R Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 75:436-47. 2004
    ..These data provide initial areas of the human genome where further investigation may reveal susceptibility genes for early-onset CAD...
  85. ncbi Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease
    Nicolas Lamblin
    Centre Hospitalier Universitaire de Lille, Lille Cedex, France
    J Am Coll Cardiol 40:43-8. 2002
    ..Our hypothesis was that functional polymorphisms in matrix metalloproteinase (MMP) genes may act as susceptibility factors for the development of coronary aneurysms (CAs)...
  86. ncbi Low TGF-beta1 serum levels are a risk factor for atherosclerosis disease in ESRD patients
    Sergio Stefoni
    Nephrology Dialysis and Renal Transplantation Unit, Department of Clinical Medicine and Applied Biotechnology, S Orsola University Hospital, Bologna, Italy
    Kidney Int 61:324-35. 2002
    ....
  87. ncbi Stress echocardiography
    E Picano
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Curr Pharm Des 11:2137-49. 2005
    ....
  88. ncbi Health status predicts long-term outcome in outpatients with coronary disease
    John A Spertus
    Mid America Heart Institute and University of Missouri Kansas City, Kansas City, MO 64111, USA
    Circulation 106:43-9. 2002
    ..Demonstrating that they independently predict mortality and hospitalizations among outpatients with coronary disease could emphasize their clinical value...
  89. ncbi The impact of renal insufficiency on patients' outcomes in emergent angioplasty for acute myocardial infarction
    Abid R Assali
    The Cardiac Catheterization Laboratories, Cardiology Department, Rabin Medical Center, 39 Jabotinsky Road, Petah Tikva 49100, Israel
    Catheter Cardiovasc Interv 69:395-400. 2007
    ..Objectives: The authors analyzed the outcomes of AMI patients with impaired renal function tests treated using primary percutaneous coronary intervention (PCI), to determine factors associated with increased mortality risk...
  90. ncbi Inflammatory markers, angiographic severity of coronary artery disease, and patient outcome
    Rishi Sukhija
    Division of Cardiovascular Medicine, Central Arkansas Veterans Healthcare System, and University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Am J Cardiol 99:879-84. 2007
    ..In conclusion, in patients hospitalized with chest pain, we found no association of serum levels of hs-CRP, IL-6, or TNF-alpha with coronary atherosclerotic burden or MACEs at 6 months after adjustment for traditional CAD risk factors...
  91. ncbi Frequency of slow coronary flow following successful stent implantation and effect of Nitroprusside
    Flavio Airoldi
    San Raffaele Hospital IRCCS, Milan, Italy
    Am J Cardiol 99:916-20. 2007
    ..In conclusion, the standardized protocol of intracoronary NTP administration succeeded in normalizing SCF in all patients with AMI but in only 5 of 9 patients with SVG stenosis. This latter subgroup requires other therapeutic strategies...
  92. ncbi [Life saving angioplasty of left main coronary artery in a high risk patient]
    Jacek Arkowski
    Klinika Kardiologii AM, ul M Skłodowskiej Curie 66, 53 369 Wrocław
    Kardiol Pol 64:1121-4; discussion 1125. 2006
    ..In 9 month follow-up angiography there was no restenosis in LMCA. In patients to whom cardiac surgery presents very high risk, an angioplasty of LMCA can be life-saving, with good long term effects...
  93. ncbi Off-pump supraarterial decompression myotomy for myocardial bridging
    Mersa M Baryalei
    Department of Thoracic and Cardiovascular Surgery, Georg August University Gottingen, Germany
    Heart Surg Forum 8:E49-54; discussion E49-54. 2005
    ..Surgery with cardiopulmonary bypass (CPB) is a therapeutic option with considerable risk. We hypothesized that off-pump supraarterial myotomy could be an effective treatment modality...
  94. ncbi Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome
    Erdal Cavusoglu
    Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Am J Cardiol 99:1364-8. 2007
    ..34 ng/ml was 88% compared with 74% in those whose values were >20.34 ng/ml (p = 0.0249 by log-rank test). In conclusion, these data demonstrate that baseline MPO levels independently predict MI at 2 years in patients with ACS...
  95. ncbi Prognostic value of myocardial contrast echocardiography in patients presenting to hospital with acute chest pain and negative troponin
    Paramjit Jeetley
    Department of Cardiovascular Medicine, Northwick Park Hospital and Institute for Medical Education and Research, Harrow, Middlesex, United Kingdom
    Am J Cardiol 99:1369-73. 2007
    ..0003). In conclusion, stress MCE was superior to TIMI risk score and exercise electrocardiography in the assessment of risk in patients with suspected acute coronary syndrome, nondiagnostic electrocardiogram, and negative troponin...
  96. ncbi Procalcitonin in patients with acute coronary syndrome: correlation with high-sensitive C-reactive protein, prognosis and severity of coronary artery disease
    Tunay Senturk
    Department of Cardiology, Uludag University School of Medicine Bursa, Turkey
    Acta Cardiol 62:135-41. 2007
    ....
  97. pmc The effect of electrical neurostimulation on collateral perfusion during acute coronary occlusion
    Jessica de Vries
    Dept of Cardiology, Thoraxcenter, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    BMC Cardiovasc Disord 7:18. 2007
    ..We sought to study the effect of electrical neurostimulation on collateral perfusion...
  98. ncbi Predictors and prognosis for complex coronary lesions in patients with acute myocardial infarction: data from RICO survey
    Gilles Rioufol
    Service de cardiologie, CHU Bocage, Bd Mal de Lattre de Tassigny, Dijon, France
    Am Heart J 154:330-5. 2007
    ..We aimed to investigate the determinants and outcomes of multiple complex lesions (MCLs) on coronary angiography in patients with an acute myocardial infarction...
  99. pmc Hybrid coronary revascularization in high-risk patients
    Melih Hulusi Us
    Department of Cardiovascular Surgery, GATA Haydarpasa Training Hospital, 81080 Istanbul, Turkey
    Tex Heart Inst J 33:458-62. 2006
    ..Hybrid coronary revascularization enables complete revascularization and may be an alternative method of treating selected patients who have concomitant disease...
  100. ncbi In-hospital and nine-month outcome of treatment of coronary bifurcational lesions with sirolimus-eluting stent
    Lei Ge
    EMO Centro Cuore Columbus and San Raffaele Hospital, Milan, Italy Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
    Am J Cardiol 95:757-60. 2005
    ..4% vs 8.9%, p = 0.76), target vessel revascularization (5.4% vs 11.1%, p = 0.51), and cumulative major adverse cardiac events (18.9% vs 23.3%, p = 0.76) at 9 months...
  101. ncbi Progression of coronary artery calcium and occurrence of myocardial infarction in patients with and without diabetes mellitus
    Paolo Raggi
    Tulane University School of Medicine, 1430 Tulane Ave, SL 48, New Orleans, LA 70112, USA
    Hypertension 46:238-43. 2005
    ....

Research Grants78

  1. Role of NFY in Irradiation Induced Gene activation
    Nadia Jahroudi; Fiscal Year: 2002
    ..endothelial cells is thus a major cause of complications including, thrombus formation, premature coronary arteriosclerosis, and myocardial infarction, or fibrosis, that occur as a consequence of irradiation therapy...
  2. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  3. Proteomic Markers of Arteriosclerosis
    Iftikhar Kullo; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  4. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  5. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  6. Atherothrombosis
    Peter Libby; Fiscal Year: 2005
    ..This effort will hasten the translation of research discoveries to promote health of the heart and blood vessels at home and abroad. ..
  7. Inflammatory Mechanisms of Atherosclerosis
    Peter Libby; Fiscal Year: 2006
    ..5. We will explore a putative functional role of a novel prostaglandin E2 receptor EP4 interacting protein (EPRAP) in endogenous anti-inflammatory pathways. ..
  8. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..
  9. Cardiac MDCT for Early Triage of Patients with ACS
    Udo Hoffmann; Fiscal Year: 2008
    ..abstract_text> ..
  10. Socioeconimic Patterning of Inflammation and Hemostasis
    Ana Diez Roux; Fiscal Year: 2007
    ..The study will provide a unique opportunity to elucidate the links between socioeconomic factors, stress, inflammation and hemostasis in a large and diverse population-based sample. ..
  11. Inflammation, Procoagulation, and Plaque Vulnerability
    Burton Sobel; Fiscal Year: 2005
    ..abstract_text> ..
  12. Renin Angiotensin for Coronary Microvascular Dysfunction
    Carl Pepine; Fiscal Year: 2005
    ....
  13. Pharmacogenetic Antiplatelet Strategies in CHD Patients
    Glen Cooke; Fiscal Year: 2007
    ..Such information will be paramount in the targeting of antiplatelet therapies and will be based on genomlc information (pharmacogenetics)...
  14. Outcomes of Sleep Disorders in Older Men
    Elizabeth Barrett Connor; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  15. Net Lifetime Health Effects of Alcohol Use & Abuse
    CURTIS ELLISON; Fiscal Year: 2007
    ..The study will produce a unique dataset and will provide information that should improve our knowledge of the net effects of alcohol throughout adult life. ..
  16. BARI II - FIBRINOLYSIS AND COAGULATION CORE
    Burton Sobel; Fiscal Year: 2006
    ..The investigators further expect that this collaborative effort will translate into a new practical clinical paradigm that will be used for treatment of Type II diabetic patients. ..
  17. Opioid Prescribing Patterns in the U.S.
    Mark Pletcher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. Platelet Functional Genomics in Cardiovascular Disease
    Marlene Williams; Fiscal Year: 2006
    ..By following these career goals, the candidate will eventually be able to ask pertinent questions applicable to the acute coronary syndrome and platelet function and become an independent clinical investigator. ..
  19. Serum Protemic Patterns Associated With Atherosclerosis
    Mark Pletcher; Fiscal Year: 2006
    ....
  20. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
  21. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  22. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2004
    ..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
  23. Biochemical Heterogeneity in Morbidly Obese Women in the WHI Observational Study
    Rachel Mackey; Fiscal Year: 2008
    ..This will be the first epidemiology study to specifically focus on morbidy obesity Class III unselected for weight reduction, i.e. bariatric surgery, in black and white women. ..
  24. GENCAC - Framingham Field Center
    CURTIS ELLISON; Fiscal Year: 2004
    ..abstract_text> ..
  25. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..abstract_text> ..
  26. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  27. Endogenous/Exogenous Sex Hormones & CHD Risk Factors
    Elizabeth Barrett Connor; Fiscal Year: 2003
    ..These observations may aid in deciding whether individual women should use HRT and, if so, which regimen would provide the most benefit with the least risk. ..
  28. CVD Predictors of Cognitive Function Trajectory over 20 Years
    Elizabeth L Barrett Connor; Fiscal Year: 2010
    ..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
  29. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  30. NEIGHBORHOOD ENVIRONMENTS AND CARDIOVASCULAR DISEASE
    Ana Diez Roux; Fiscal Year: 2002
    ..The investigators point ut that the proposed study builds on existing cohort studies of cardiovascular disease to explore hypotheses relevant to understanding the factors contributing to SES differences in CVD risk. ..
  31. GENDER DIFFERENCES IN OSTEOPOROSIS
    Elizabeth Barrett Connor; Fiscal Year: 2002
    ....
  32. CORONARY CALCIFICATION PROGRESSION STUDY
    JOHN CROUSE; Fiscal Year: 2001
    ..They point out that pilot data support the feasibility and likely informativeness of this study. ..
  33. Carotid Atherosclerosis (MRI) Progression Study (CAMP)
    JOHN CROUSE; Fiscal Year: 2008
    ..abstract_text> ..
  34. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2009
    ..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
  35. HYPERGEN-BOSTON UNIVERSITY/FRAMINGHAM FIELD CENTER
    CURTIS ELLISON; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  36. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  37. New Cardiac Surgery Programs: Patients, Outcomes, Access
    FRANCES LUCAS; Fiscal Year: 2008
    ..procedures or result in an overall increase in the population-based rates of care, including CABG and total revascularization (either CABG or percutaneous coronary interventions) as additional capacity is brought online? ..
  38. Long Term Effects of Subclinical CAD on Cardiac Function
    Robert Detrano; Fiscal Year: 2007
    ..The proposed research will determine the presence and extent of a link between sub-clinical atherosclerosis and its progression and subsequent cardiac function. [unreadable] [unreadable]..
  39. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2008
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  40. INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGES
    IRA A TABAS; Fiscal Year: 2010
    ..abstract_text> ..
  41. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Jay Mukamal; Fiscal Year: 2010
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  42. Discharge Planning and Telehealth for Post CABG Elders
    Ruth Kleinpell; Fiscal Year: 2009
    ....
  43. Mentored Career Development in Patient Oriented Research
    Daniel Rader; Fiscal Year: 2006
    ..abstract_text> ..
  44. Pathways for the Inflammatory Damage of Biomolecules
    Jay Heinecke; Fiscal Year: 2006
    ..abstract_text> ..
  45. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  46. Targeting Apolipoprotein E4-related Neuropathology
    Robert Mahley; Fiscal Year: 2004
    ..Ultimately, it will be our goal to take "hits" to lead compounds that may give rise to a drug that prevents or retards apoE4-related neuropathology. ..
  47. CLINICAL INVESTIGATOR TRAINING ENHANCEMENT: CITE PROGRAM
    Kurt Kroenke; Fiscal Year: 2004
    ..abstract_text> ..
  48. TRAINING IN TISSUE ENGINEERING & IMPLANT SCIENCE
    Joachim Kohn; Fiscal Year: 2004
    ..abstract_text> ..
  49. MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS
    Daniel Rader; Fiscal Year: 2004
    ..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..
  50. SES, health behaviors and CVD among Vietnam-era-Twins
    Jeanne McCaffery; Fiscal Year: 2005
    ..The primary method of analysis will be twin structural equation modeling. ..
  51. Conference on Cellular Biology of Atherosclerosis
    Ira Tabas; Fiscal Year: 2005
    ....
  52. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  53. Microvascular - Macrovascular Disease in Type 2 Diabetes
    Ronald Klein; Fiscal Year: 2005
    ....
  54. Lipid Testing /Treatment in Older MI Patients
    JoAnne Foody; Fiscal Year: 2005
    ..This work will ultimately improve care for the elderly patient with cardiovascular disease. ..
  55. GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES
    Stephen Turner; Fiscal Year: 2006
    ....
  56. Genetic Predictors of Comorbid Depressive Symptoms + CAD
    Jeanne McCaffery; Fiscal Year: 2005
    ....
  57. HOSTILITY, MARITAL INTERACTION AND HEALTH IN AGING
    Timothy Smith; Fiscal Year: 2004
    ..g., fluid and crystallized intelligence). The long-term goal of the research is to identify potentially modifiable determinants of cardiovascular risk, marital adjustment, and cognitive aging in adulthood. ..
  58. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  59. Cardiovascular-Oxytocin Links in Social Interaction
    Timothy Smith; Fiscal Year: 2005
    ..Explication of the psychobiology of social support and related psychosocial risk factors in personal relationships could guide the refinement of risk reducing, preventive interventions. ..
  60. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ....
  61. GENETIC DETERMINATION OF ALLOGRAFT VASCULOPATHY
    Raymond Benza; Fiscal Year: 2002
    ..If his faculty mentor were to leave the institution, a new mentor will be appointed and his continued development toward becoming a independent physician scientist supported and encouraged. ..
  62. Conference on Angiogenesis in Cancer and Other Diseases
    Rakesh Jain; Fiscal Year: 2002
    ..The meeting's synthesis of available information will be particularly thought-provoking for students and post- doctoral fellows. ..
  63. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  64. Mesenchymal Stem Cells and Ventricular Remodeling
    Joshua Hare; Fiscal Year: 2004
    ..Furthermore, these noninvasive techniques will be immediately transferable to human clinical trials. ..
  65. PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISM
    Paul Bray; Fiscal Year: 2001
    ..These studies will enhance our understanding of the role of integrin biology (especially in platelets), and help to achieve our long-term goal of implementing a more rational anti-thrombotic therapy. ..
  66. OXIDATIVE STRESS IN HEART FAILURE: MECHANISMS
    Joshua Hare; Fiscal Year: 2008
    ..Finally, the present studies in 3 highly relevant animal models will provide mechanistic insights complementary to those expected from ongoing clinical trials designed to test the utility of XO inhibitors in human HF therapy. ..
  67. Behavioral Ecology and Hostility & Cardiac ANS Control
    Richard Sloan; Fiscal Year: 2007
    ..Thus, we expect to demonstrate how personality traits, in combination with social interactions and behavior throughout the day, drive the risk of CHD through an autonomic mechanism. ..
  68. Cytokine-induced depression & the serotonin transporter
    Richard Sloan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  69. HOSTILITY REDUCTION AND AUTONOMIC CONTROL OF THE HEART
    Richard Sloan; Fiscal Year: 2004
    ....
  70. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
    ..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
  71. CT EVALUATION OF DIABETIC TIBIAL ARTERY CALCIFICATION
    RAUL GUZMAN; Fiscal Year: 2006
    ..Our ultimate goal is to prevent the marco-vascular complications of diabetes, and to decrease the incidence of lower extremity amputation that causes disability in our patients. ..
  72. Integrative Biology of Tumor Metastasis
    Rakesh Jain; Fiscal Year: 2009
    ..Finally, we have the resources and the clinical collaborators in place to initiate a clinical trial based on our findings, as attested by our ongoing trial using a VEGF-specific antibody. ..
  73. Anti-Angiogenesis/Drugs in Tumors--Bench /Bedside & Back
    Rakesh Jain; Fiscal Year: 2005
    ..Attendance at this conference will provide an excellent opportunity for young investigators working on cancer to educate and familiarize themselves with the field of angiogenesis and the complexities of the system. ..
  74. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  75. Postmenopause CHD risk: Platelet genes & hormone therapy
    Paul Bray; Fiscal Year: 2006
    ..abstract_text> ..
  76. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
    ..abstract_text> ..