aortic valve insufficiency

Summary

Summary: Backflow of blood from the aorta into the left ventricle, owing to imperfect functioning of the aortic semilunar valve.

Top Publications

  1. ncbi Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography
    William A Zoghbi
    J Am Soc Echocardiogr 16:777-802. 2003
  2. ncbi Evaluation of left ventricular dimensions and function in Marfan's syndrome without significant valvular regurgitation
    Lilian J Meijboom
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 95:795-7. 2005
  3. ncbi Congenital quadricuspid aortic valve: report of nine surgical cases
    Goichi Yotsumoto
    Second Department of Surgery, Kagoshima University, Faculty of Medicine, Sakuragaoka, Kagoshima, Japan
    Ann Thorac Cardiovasc Surg 9:134-7. 2003
  4. ncbi Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery
    Veronica Jackson
    Cardiothoracic Surgery Unit at the Department of Molecular Medicine and Surgery at Karolinska Institutet and Karolinska University Hospital
    Eur J Cardiothorac Surg 40:e118-24. 2011
  5. ncbi Quadricuspid aortic valve plasty: is it worth it to repair as an alternative to substitution?
    Andrea Daprati
    Department of Cardiovascular Disease, Cardiac Surgery Unit, IRCCS Centro Cardiologico Fondazione Monzino, Milano, Italy
    Ann Thorac Surg 95:e7-8. 2013
  6. ncbi Quadricuspid aortic valve: a rare etiology of aortic regurgitation
    O Godefroid
    Cardiology Unit, Mont Godinne University Hospital, Avenue G Therasse 1, B 5530 Yvoir, Belgium
    Eur J Echocardiogr 7:168-70. 2006
  7. ncbi Cardiovascular changes in children with mucopolysaccharide disorders
    U R Mohan
    Departments of Paediatric Cardiology and Paediatric Metabolic Medicine Willink Biochemical Genetics Unit, Royal Manchester Children s Hospital, Hospital Road, Pendelbury, Manchester, UK
    Acta Paediatr 91:799-804. 2002
  8. ncbi Bicuspid aortic valve associated with aortic dilatation: a community-based study
    Vuyisile T Nkomo
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 23:351-6. 2003
  9. ncbi Regression of left ventricular hypertrophy during 10 years after valve replacement for aortic stenosis is related to the preoperative risk profile
    Ole Lund
    Department of Thoracic and Cardiovascular Surgery, Aarhus University Hospital in Skejby, Aarhus, Denmark
    Eur Heart J 24:1437-46. 2003
  10. pmc Prevalence and clinical significance of incidental paraprosthetic valvar regurgitation: a prospective study using transoesophageal echocardiography
    A Ionescu
    University of Wales College of Medicine, Cardiff, UK
    Heart 89:1316-21. 2003

Research Grants

  1. Rapid Flow Evaluaton by Magnetic Resonance Imaging
    Mark Doyle; Fiscal Year: 2006
  2. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
  3. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2008
  4. Genetic Basis of Aortic Aneurysms/Dissections
    Dianna Milewicz; Fiscal Year: 2009
  5. Libman-Sacks Endocarditis and NPSLE
    Carlos Roldan; Fiscal Year: 2009
  6. DETERMINANTS OF PROCEDURE USE IN MYOCARDIAL INFARCTION
    James Jollis; Fiscal Year: 2003
  7. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
  8. MICROSCOPIC CARDIAC MATERIAL PROPERTIES IN AGING
    Samuel Wickline; Fiscal Year: 2002
  9. Thrombophilia In Cryptogenic Stroke (THICK) Study
    JORGE KIZER; Fiscal Year: 2006
  10. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007

Detail Information

Publications234 found, 100 shown here

  1. ncbi Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography
    William A Zoghbi
    J Am Soc Echocardiogr 16:777-802. 2003
  2. ncbi Evaluation of left ventricular dimensions and function in Marfan's syndrome without significant valvular regurgitation
    Lilian J Meijboom
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 95:795-7. 2005
    ..Some involvement of the left ventricle may have been present in a small group of these patients. No patients, however, fulfilled the criteria for dilated cardiomyopathy...
  3. ncbi Congenital quadricuspid aortic valve: report of nine surgical cases
    Goichi Yotsumoto
    Second Department of Surgery, Kagoshima University, Faculty of Medicine, Sakuragaoka, Kagoshima, Japan
    Ann Thorac Cardiovasc Surg 9:134-7. 2003
    ..Valve repair failed in one patient and was converted to valve replacement during the operation. All patients underwent successful aortic valve replacement (AVR)...
  4. ncbi Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery
    Veronica Jackson
    Cardiothoracic Surgery Unit at the Department of Molecular Medicine and Surgery at Karolinska Institutet and Karolinska University Hospital
    Eur J Cardiothorac Surg 40:e118-24. 2011
    ....
  5. ncbi Quadricuspid aortic valve plasty: is it worth it to repair as an alternative to substitution?
    Andrea Daprati
    Department of Cardiovascular Disease, Cardiac Surgery Unit, IRCCS Centro Cardiologico Fondazione Monzino, Milano, Italy
    Ann Thorac Surg 95:e7-8. 2013
    ..1 according to Hurwits and Roberts classification) with a marked lack of coaptation that caused a severe aortic valve insufficiency. The patient underwent a repair of the defect with a tricuspidalization of the aortic valve, restoring ..
  6. ncbi Quadricuspid aortic valve: a rare etiology of aortic regurgitation
    O Godefroid
    Cardiology Unit, Mont Godinne University Hospital, Avenue G Therasse 1, B 5530 Yvoir, Belgium
    Eur J Echocardiogr 7:168-70. 2006
    ..We report two unusual cases of this valvular pathology associated with a dilatation of the aortic root. The mechanism leading to this valve incompetence is incompletely understood and is discussed in regard to these cases...
  7. ncbi Cardiovascular changes in children with mucopolysaccharide disorders
    U R Mohan
    Departments of Paediatric Cardiology and Paediatric Metabolic Medicine Willink Biochemical Genetics Unit, Royal Manchester Children s Hospital, Hospital Road, Pendelbury, Manchester, UK
    Acta Paediatr 91:799-804. 2002
    ..However, left ventricular hypertrophy, mitral valve abnormalities and type II MPS were not significant risk factors for death, with borderline significance for aortic valve abnormalities...
  8. ncbi Bicuspid aortic valve associated with aortic dilatation: a community-based study
    Vuyisile T Nkomo
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 23:351-6. 2003
    ..An independent association of BAV and aortic dilatation in a community-based study has not been demonstrated...
  9. ncbi Regression of left ventricular hypertrophy during 10 years after valve replacement for aortic stenosis is related to the preoperative risk profile
    Ole Lund
    Department of Thoracic and Cardiovascular Surgery, Aarhus University Hospital in Skejby, Aarhus, Denmark
    Eur Heart J 24:1437-46. 2003
    ..The potential for hypertrophy regression could therefore be related to the preoperative risk profile...
  10. pmc Prevalence and clinical significance of incidental paraprosthetic valvar regurgitation: a prospective study using transoesophageal echocardiography
    A Ionescu
    University of Wales College of Medicine, Cardiff, UK
    Heart 89:1316-21. 2003
    ..To assess the prevalence, mechanisms, and significance of paraprosthetic regurgitation detected incidentally by transoesophageal echocardiography (TOE) in patients after heart valve replacement...
  11. ncbi Tricuspidation of quadricuspid aortic valve: case reports
    Hugues Jeanmart
    Department of Cardiothoracic and Vascular Surgery, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    J Heart Valve Dis 16:148-50. 2007
    ..After one year and six months' follow up, respectively, both patients presented with trivial aortic regurgitation and good mobility of the three leaflets...
  12. ncbi Percutaneous aortic valve replacement: resection before implantation
    Rene Quaden
    Department of Cardiovascular Surgery, School of Medicine, Christian Albrechts University of Kiel, Arnold Heller Strasse 7, D 24105 Kiel, Germany
    Eur J Cardiothorac Surg 27:836-40. 2005
    ..After transluminal endovascular implantation of a new valved stent, the aim of this study was to evaluate the feasibility of using a high-pressure water stream to endovascularly resect human calcified aortic valves...
  13. ncbi Quadricuspid aortic valve with ascending aortic aneurysm: report of a case and discussion of embryological mechanisms
    Robert R Attaran
    Sarver Heart Center, University of Arizona, Tucson, AZ 85724, USA
    Cardiovasc Pathol 18:49-52. 2009
    ..We describe the case of a patient with a QAV associated with aortic aneurysm. Pertinent literature on the QAV is reviewed, and embryological factors that may contribute to its pathogenesis are discussed...
  14. ncbi Transcatheter aortic valve implantation for stenosed and regurgitant aortic valve bioprostheses CoreValve for failed bioprosthetic aortic valve replacements
    Muhammed Z Khawaja
    Sussex Cardiac Centre, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK
    J Am Coll Cardiol 55:97-101. 2010
    ..We present the first series of such patients with degenerative bioprosthetic stenosis or regurgitation successfully treated with CoreValve (Medtronic, Luxembourg) implantation...
  15. ncbi Effects of exercise training after open heart surgery on quality of life and exercise tolerance in patients with mitral regurgitation or aortic regurgitation
    Kenji Ueshima
    Iwate Medical University, Memorial Heart Center, Iwate 020 8505, Japan
    Jpn Heart J 45:789-97. 2004
    ..It is suggested that changes in subjective and social parameters contribute to an exercise training-related improvement in the QOL...
  16. ncbi Steps toward percutaneous aortic valve replacement
    Younes Boudjemline
    Service de Cardiologie Pediatrique, Hopital Necker Enfants Malades, Paris, France
    Circulation 105:775-8. 2002
    ..Percutaneous pulmonary valve replacement has recently opened new perspectives on transcatheter replacement of cardiac valves. We report our experience of aortic valve replacement through a percutaneous technique in lambs...
  17. ncbi Aortic valve repair for quadricuspid aortic valve associated with aortic regurgitation and ascending aortic aneurysm
    Kozo Naito
    Department of Cardiovascular Surgery, Saga Prefectural Hospital, Koseikan, 1 12 9 Mizugae, Saga 840 8571, Japan
    J Thorac Cardiovasc Surg 128:759-60. 2004
  18. ncbi Successful repair of a quadricuspid aortic valve illustrated by transoesophageal echocardiography, 64-slice multidetector computed tomography, and cardiac magnetic resonance
    Anne Catherine Pouleur
    Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10 2806, B 1200 Woluwe St Lambert, Brussels, Belgium
    Eur Heart J 28:2769. 2007
  19. ncbi Congenital quadricuspid aortic valve: analysis of 11 surgical cases
    Yang feng Tang
    Department of Cardiothoracic Surgery, Changhai Hospital of the Second Military Medical University, Shanghai 200433, China
    Chin Med J (Engl) 124:2779-81. 2011
    ..Congenital quadricuspid aortic valve is rarely seen during aortic valve replacement (AVR). The diagnosis and treatment of the disease were reported in 11 cases...
  20. ncbi Images in cardiovascular medicine. A quadricuspid aortic valve with severe aortic regurgitation
    Michèle Desruennes
    Clinique La Francilienne, Pontault Combault, France
    Circulation 114:e642-3. 2006
  21. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
    ....
  22. pmc Quadricuspid aortic valve in a patient with mitral valve prolapse
    Mehmet Fatih Ozlu
    Department of Cardiology, Yuksek Ihtisas Hospital, Ankara, Turkey
    Can J Cardiol 24:e27. 2008
  23. ncbi Left ventricular function in the Marfan syndrome without significant valvular regurgitation
    Ritu Chatrath
    Division of Pediatric Cardiology, Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 91:914-6. 2003
  24. ncbi Multiple intracardiac lesions after blunt chest trauma
    A Aris
    Department of Cardiac Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Ann Thorac Surg 70:1692-4. 2000
    ..He underwent surgical repair of these lesions, but aortic insufficiency developed 2 years later and the aortic valve was replaced with a mechanical prosthesis...
  25. ncbi Cardiology patient pages. Aortic valve disease
    Rick A Nishimura
    Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA rnishimura mayo edu
    Circulation 106:770-2. 2002
  26. ncbi Reoperation after the Ross procedure: incidence, management, and survival
    Francis Juthier
    Department of Cardiovascular Surgery, Centre Hospitalier Regional et Universitaire de Lille, Lille, France
    Ann Thorac Surg 93:598-604; discussion 605. 2012
    ..The risk of reoperation on the autograft and homograft is the major long-term drawback of the Ross procedure. The incidence and clinical implications of reoperations after the Ross procedure are reported...
  27. ncbi Prevalence and associated risk factors for intervention in 313 children with subaortic stenosis
    Tara Karamlou
    Division of Cardiovascular Surgery, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 84:900-6; discussion 906. 2007
    ....
  28. ncbi Impact of prosthesis-patient mismatch on long-term survival in patients with small St Jude Medical mechanical prostheses in the aortic position
    Dania Mohty
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 113:420-6. 2006
    ..The impact of aortic prosthesis-patient mismatch (P-PtM) on long-term survival is unclear...
  29. ncbi Preliminary results following reinforcement of the pulmonary autograft to prevent dilatation after the Ross procedure
    Thierry Carrel
    Clinic for Cardiovascular Surgery, University Hospital, University Berne, Berne, Switzerland
    J Thorac Cardiovasc Surg 136:472-5. 2008
    ..We present our early experience with an external reinforcement of the autograft, which is inserted into a prosthetic Dacron graft with an artificial aortic root configuration. This detail should help to prevent neoaortic root dilatation...
  30. ncbi Transesophageal echocardiographic scoring for transcatheter aortic valve implantation: impact of aortic cusp calcification on postoperative aortic regurgitation
    Andrea Colli
    Department of Cardiac Surgery, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
    J Thorac Cardiovasc Surg 142:1229-35. 2011
    ..The aim of this study was to evaluate whether echocardiographic assessment of aortic stenosis using a calcification score is useful to predict outcomes of transcatheter aortic valve implantation in elderly high-risk patients...
  31. ncbi Ross and Ross-Konno procedure in children and adolescents: mid-term results
    V Hraska
    Department of Pediatric Cardiac Surgery, University Hospital Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
    Eur J Cardiothorac Surg 25:742-7. 2004
    ..The aim of the study was to analyze mid-term results of aortic root replacement with pulmonary autograft in children and adolescents in two centers...
  32. ncbi Left ventricular remodeling with intensive exercise after aortic valve replacement
    Axel Pressler
    Department for Prevention and Sports Medicine, Technische Universitat Munchen, Munich, Germany
    J Heart Valve Dis 20:91-3. 2011
    ..These findings indicate that even intensive endurance training after AVR seems to be feasible and safe, and may have a beneficial effect on postoperative cardiac remodeling...
  33. ncbi Dilatation of the pulmonary autograft and native aorta after the Ross procedure: a comprehensive echocardiographic study
    Obaid Aljassim
    Department of Cardiovascular Surgery and Anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Thorac Cardiovasc Surg 142:634-40, 640.e1. 2011
    ..Whether the remaining native aorta dilates is not known. The aim of the study was to describe the prevalence and severity of autograft and native aortic dilatation over time and to identify possible determinants...
  34. ncbi The Ross procedure in children: preoperative haemodynamic manifestation has significant effect on late autograft re-operation
    Bahaaldin Alsoufi
    King Faisal Heart Institute, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Eur J Cardiothorac Surg 38:547-55. 2010
    ..We examined whether preoperative haemodynamic manifestation (e.g., stenosis, regurgitation and mixed aortic valve disease) affected late re-operation risk...
  35. ncbi Measurement of physical work capacity in patients with chronic aortic regurgitation: a potential improvement in patient management
    Eva Tamás
    Department of Cardiothoracic Surgery, Ostergötland Heart Centre, University Hospital and Department of Medical and Health Sciences, University of Linkoping, Linkoping, Sweden
    Clin Physiol Funct Imaging 29:453-7. 2009
    ..Exercise testing is recommended upon uncertainty about functional limitations but reports on cardiopulmonary exercise testing (CPET) in populations with pure chronic AR are scarce...
  36. ncbi The role of cardiopulmonary exercise test in mitral and aortic regurgitation: it can predict post-operative results
    Hyun Joong Kim
    Division of Cardiovascular Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 170, Korea
    Korean J Intern Med 18:35-9. 2003
    ..We evaluated the efficacy of the cardiopulmonary exercise test as an objective indicator of functional status and as a pre-operative prognostic indicator in patients with mitral regurgitation (MR) and aortic regurgitation (AR)...
  37. ncbi Ross operation in children: late results
    R C Elkins
    Section of Thoracic and Cardiovascular Surgery, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    J Heart Valve Dis 10:736-41. 2001
    ..CONCLUSION: Survival and freedom from aortic valve replacement are excellent in children. Homograft valve late function remains a concern, and efforts to improve homograft durability should be encouraged...
  38. ncbi Acute aortic valve insufficiency and cardiogenic shock due to an isolated giant cell inflammation of the aortic valve leaflets: case report and review of the literature
    Lars Niclauss
    Department of Cardiovascular Surgery, University Hospital CHUV, Lausanne, Switzerland
    J Heart Valve Dis 17:343-7. 2008
    ..institution with acute cardiac failure, severe left ventricular systolic dysfunction and grade III aortic valve insufficiency. The aortic valve was excised and replaced in the usual manner with a pericardial tissue heart valve...
  39. ncbi Long-term results of a strategy of aortic valve repair in the pediatric population
    Yves d'Udekem
    Department of Cardiac Surgery, Royal Children s Hospital, Flemington Rd, Parkville, Melbourne 3052, Victoria, Australia
    J Thorac Cardiovasc Surg 145:461-7; discussion 467-9. 2013
    ..To determine rate of reoperation subsequent to primary valve repair in a pediatric population...
  40. ncbi Multiple floppy valves with all cardiac valves prolapsing: clinical course and treatment
    K Suzuki
    Department of Pediatric Cardiology, Sakakibara Heart Institute, Tokyo, Japan
    Pediatr Cardiol 12:110-3. 1991
    ..None of the patients had any stigmata of Marfan or Ehlers-Danlos syndrome, except for the presence of hyperextensive joints. There may be an unknown collagen disorder that caused floppiness in all the valves...
  41. ncbi The Ross operation in children and young adults: a fifteen-year, single-institution experience
    Joseph B Clark
    Department of Pediatrics, Penn State Hershey, Hershey, Pennsylvania 17033, USA
    Ann Thorac Surg 91:1936-41; discussion 1941-2. 2011
    ..The goal of this study is to report our experience with the Ross operation and the need for reintervention at intermediate follow-up...
  42. ncbi Surgical treatment of subaortic obstruction in adolescent and adults: long-term follow-up
    Vedat Erentug
    Department of Cardiovascular Surgery, Kosuyolu Heart and Research Hospital, Istanbul, Turkey
    J Card Surg 20:16-21. 2005
    ....
  43. ncbi Major adverse cardiac and cerebrovascular events after the Ross procedure: a report from the German-Dutch Ross Registry
    Hans H Sievers
    University of Luebeck, Department of Cardiac and Thoracic Vascular Surgery, Luebeck, Germany
    Circulation 122:S216-23. 2010
    ..These data could provide an additional basis for discussions among physicians and a source of information for patients...
  44. ncbi Exercise performance in children and adolescents after the Ross procedure
    Bradley S Marino
    Division of Cardiology, at the Cardiac Center of The Children s Hospital of Philadelphia, and the Department of Pediatrics at the University of Pennsylvania School of Medicine 19104, USA
    Cardiol Young 16:40-7. 2006
    ..The Ross procedure is increasingly utilized in the treatment of aortic valvar disease in children and adolescents. Our purpose was to compare pre- and post-operative exercise state in this population...
  45. ncbi ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Manage
    Robert O Bonow
    Circulation 114:e84-231. 2006
  46. ncbi Hemodynamics and early performance of the St. Jude Medical Regent aortic valve prosthesis
    D S Bach
    The Department of Medicine, University of Michigan, Ann Arbor 48109, USA
    J Heart Valve Dis 10:436-42. 2001
    ..In all cases of adverse events, rates fell within Objective Performance Criteria guidelines. Long-term clinical assessment is on-going...
  47. ncbi Is aortic wall degeneration related to bicuspid aortic valve anatomy in patients with valvular disease?
    Claudio F Russo
    Angelo De Gasperis Department of Cardiac Surgery, Niguarda Ca Granda Hospital, Piazza Ospedale Maggiore, Milan, Italy
    J Thorac Cardiovasc Surg 136:937-42. 2008
    ..Patients with bicuspid aortic valve are at increased risk for aortic complications...
  48. ncbi Aortic valve replacement in patients with impaired ventricular function
    Ram Sharony
    Division of Cardiothoracic Surgery, Department of Surgery, New York University School of Medicine, New York, New York, USA
    Ann Thorac Surg 75:1808-14. 2003
    ..Patients with reduced ventricular function undergoing aortic valve replacement have increased operative risks, but the impact of valvular pathophysiology and other risk factors has not been clearly defined...
  49. ncbi The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in infants, children, and young adults
    Sara K Pasquali
    Division of Cardiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 49:1806-12. 2007
    ..The purpose of this study was to describe the relationship between neo-aortic root size, neo-aortic insufficiency (AI), and reintervention at mid-term follow-up...
  50. ncbi Surgical management of aortic regurgitation associated with takayasu arteritis and other forms of aortitis
    Osamu Adachi
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Ann Thorac Surg 84:1950-3. 2007
    ..Postoperative morbidity includes progressive dilatation of the aortic root. We sought to assess our midterm and long-term results of surgical management of aortic regurgitation associated with aortitis...
  51. ncbi Traumatic aortic regurgitation: aortic valvuloplasty controlled by aortoscopy
    J P Meunier
    Department of Cardiac Surgery, Pasteur Hospital, University of Nice, France
    J Heart Valve Dis 10:784-8. 2001
    ..Replacement is the safest treatment for complex or multiple injuries of the aortic valve, however...
  52. ncbi Effect of valve suture technique on incidence of paraprosthetic regurgitation and 10-year survival
    Sukumaran K Nair
    Department of Cardiothoracic Surgery, St George s Hospital NHS Trust, London, United Kingdom
    Ann Thorac Surg 89:1171-9. 2010
    ..The secondary objective was to estimate the risk of redo valve surgery and 10-year survival after valve replacement performed using either suture technique...
  53. ncbi One year hemodynamic performance of the Perimount Magna pericardial xenograft and the Medtronic Mosaic bioprosthesis in the aortic position: a prospective randomized study
    María José Dalmau
    Department of Cardiac Surgery, Salamanca University Hospital, Paseo de San Vicente 58 182, 37007 Salamanca, Spain
    Interact Cardiovasc Thorac Surg 6:345-9. 2007
    ..8% (MM) vs. 6.9% (EPM) of the patients (P=0.01). When the same AAD is taken as a reference, the EPM-valve was hemodynamically superior to the MM-bioprosthesis. The EPM-prosthesis significantly reduced the incidence of PPM...
  54. ncbi Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine
    D H Ryan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 7:313-22. 1999
    ..We studied 86 patients who had echocardiograms before treatment with appetite suppressants to determine the incidence of new cases and to evaluate the clinical implication of the echocardiographic findings...
  55. ncbi Surgical treatment of aortic regurgitation due to Takayasu arteritis: long-term morbidity and mortality
    Kaoru Matsuura
    Department of Cardiovascular Surgery, National Cardiovascular Center, Suita, Osaka, Japan
    Circulation 112:3707-12. 2005
    ..The goal of this retrospective study was to determine the late outcome of surgical treatment for aortic valve regurgitation due to Takayasu arteritis and correlate it with evidence of inflammation on pathological examination...
  56. ncbi Evaluation of aortic valve disorders using stress echocardiography
    Wen Chih Wu
    Division of Cardiology, Providence VA Medical Center, and The Miriam Hospital, Brown Medical School, Providence, Rhode Island 02908, USA
    Echocardiography 21:459-66. 2004
    ....
  57. ncbi Risk factor analysis for proximal and distal reoperations after surgery for acute type A aortic dissection
    Matthias Kirsch
    Service de Chirurgie Thoracique et Cardiovasculaire, Hopital Henri Mondor, Creteil, France
    J Thorac Cardiovasc Surg 123:318-25. 2002
    ..This study was undertaken to determine significant risk factors for proximal or distal reoperations after surgical correction of acute type A aortic dissection...
  58. ncbi Aortic valve sclerosis is associated with systemic endothelial dysfunction
    Elisa Poggianti
    Echocardiography Laboratory, Institute of Clinical Physiology, CNR, Pisa, Italy
    J Am Coll Cardiol 41:136-41. 2003
    ..We sought to examine the association between aortic valve sclerosis (AVS) and systemic endothelial manifestations of the atherosclerotic process...
  59. ncbi Is prosthesis-patient mismatch a clinically relevant entity?
    Tirone E David
    Circulation 111:3186-7. 2005
  60. ncbi Valvular heart disease: aortic regurgitation
    Raffi Bekeredjian
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Circulation 112:125-34. 2005
    ..The goal of vasodilator therapy is to achieve a significant decrease in systolic arterial pressure. Future therapies may focus on molecular mechanisms to prevent adverse LV remodeling and fibrosis...
  61. ncbi 64-slice multidetector computed tomography (MDCT) for detection of aortic regurgitation and quantification of severity
    Davinder S Jassal
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, and the Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Invest Radiol 42:507-12. 2007
    ..Recent advances in 64-slice multidetector computed tomography (MDCT) provide an opportunity to assess coronary artery disease, left ventricular function and, potentially, valvular heart disease...
  62. ncbi Echocardiographic and histological assessment of age-related valvular changes in normal rats
    Steven Droogmans
    Department of Cardiology, UZ Brussel, Laarbeeklaan 101, Brussels, Belgium
    Ultrasound Med Biol 35:558-65. 2009
    ..In conclusion, aging leads to morphologic and functional valvular changes in normal rats. This is important when investigating models of valvular heart disease in small animals...
  63. ncbi Aortic valves stenosis and regurgitation: assessment with dual source computed tomography
    Xiaofei Li
    Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    Int J Cardiovasc Imaging 25:591-600. 2009
    ..DSCT can achieve an exhaustive and comprehensive preoperative assessment of patients with AS and AR...
  64. ncbi Qualitative echocardiographic assessment of aortic valve regurgitation with quantitative cardiac magnetic resonance: a comparative study
    Shelby Kutty
    University of Nebraska Creighton University Joint Division of Pediatric Cardiology, Children s Hospital and Medical Center, Omaha, NE 68114, USA
    Pediatr Cardiol 30:971-7. 2009
    ..Quantitative CMR is a potentially useful supplement to ECHO for management decisions and assessments of medical and surgical therapies in children and young adults with AR...
  65. ncbi Comprehensive assessment of the severity and mechanism of aortic regurgitation using multidetector CT and MR
    Céline Goffinet
    Cardiology Division, Cliniques Universitaires St Luc UCL, Av Hippocrate 10 2806, 1200, Woluwe St Lambert, Belgium
    Eur Radiol 20:326-36. 2010
    ..Measurement of ARO by both MDCT and MR allows accurate quantitative assessment of AR. Both techniques can also accurately determine the mechanism of AR...
  66. ncbi Aortic regurgitation: assessment with 64-section CT
    Hatem Alkadhi
    Institute of Diagnostic Radiology, Clinic for Cardiovascular Surgery, and Cardiovascular Center, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Radiology 245:111-21. 2007
    ..To prospectively evaluate diagnostic accuracy of 64-section computed tomography (CT) for evaluation of aortic regurgitation (AR), with transthoracic echocardiography (TTE) as reference...
  67. ncbi Clinical practice. Aortic regurgitation
    Maurice Enriquez-Sarano
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    N Engl J Med 351:1539-46. 2004
  68. ncbi Effectiveness of beta-blockade in experimental chronic aortic regurgitation
    Eric Plante
    Groupe de Recherche sur les Valvulopathies, Centre de recherche Hopital Laval, Institut de Cardiologie de Quebec, Universite Laval, Quebec, Canada
    Circulation 110:1477-83. 2004
    ..We therefore tested the effects of metoprolol treatment on the left ventricular (LV) function and remodeling in severe chronic AR in rats...
  69. ncbi Hemodynamic evaluation of aortic regurgitation by magnetic resonance imaging
    Thomas Wittlinger
    Department of Thoracic and Cardiovascular Surgery, University Hospital, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Asian Cardiovasc Thorac Ann 16:278-83. 2008
    ....
  70. ncbi Long-term vasodilator therapy in patients with severe aortic regurgitation
    Artur Evangelista
    Servei de Cardiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
    N Engl J Med 353:1342-9. 2005
    ..Accordingly, it has been suggested that such therapy may reduce or delay the need for aortic-valve replacement...
  71. ncbi Surgical strategy for the bicuspid aortic valve: tricuspidization with cusp extension versus pulmonary autograft
    David Michael McMullan
    Cardiovascular Surgery, Children s National Medical Center, Washington, DC, USA
    J Thorac Cardiovasc Surg 134:90-8. 2007
    ..This study compares the midterm clinical outcome in patients undergoing valve repair by tricuspidization with cusp extension with those receiving a pulmonary autograft (Ross)...
  72. ncbi Bicuspidization of the unicuspid aortic valve: a new reconstructive approach
    Hans Joachim Schäfers
    Department of Thoracic and Cardiovascular Surgery, University Hospitals of Saarland, Homburg Saar, Germany
    Ann Thorac Surg 85:2012-8. 2008
    ..Unicuspid anatomy of the aortic valve is infrequent but may require intervention by age 40 for severe regurgitation. We propose a new repair technique for the regurgitant unicuspid valve by converting it into a bicuspid aortic valve...
  73. ncbi Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation
    Michio Nakanishi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Circ J 71:1310-6. 2007
    ..In the present study it was examined whether blockade of angiotensin II type 1 receptor (AT1) could improve survival in cases of chronic severe AR...
  74. ncbi Causes of pure aortic regurgitation in patients having isolated aortic valve replacement at a single US tertiary hospital (1993 to 2005)
    William Clifford Roberts
    Department of Pathology, Division of Cardiology, Baylor Heart and Vascular Institute, Baylor University Medical Center, 3500 Gaston Ave, Dallas, TX 75246, USA
    Circulation 114:422-9. 2006
    ..The causes of aortic regurgitation (AR) severe enough to warrant aortic valve replacement (AVR) have received little attention in the last 20 years...
  75. ncbi Severity of mitral and aortic regurgitation as assessed by cardiovascular magnetic resonance: optimizing correlation with Doppler echocardiography
    Eli V Gelfand
    Department of Medicine Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cardiovasc Magn Reson 8:503-7. 2006
    ..Therefore, we sought to define the CMR regurgitant fractions that best correlate with qualitative mild, moderate, and severe regurgitation by color Doppler echocardiography...
  76. ncbi Diagnostic performance of MDCT for detecting aortic valve regurgitation
    Gudrun M Feuchtner
    Clinical Department of Radiology II, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    AJR Am J Roentgenol 186:1676-81. 2006
    ..This study evaluates whether ECG-gated 16-MDCT coronary angiography provides a reliable imaging technique for detecting aortic regurgitation (AR)...
  77. ncbi Valvular heart disease: focus on women
    Catherine M Otto
    Division of Cardiology, University of Washington, Seattle, Washington 98195, USA
    Cardiol Rev 15:291-7. 2007
    ....
  78. ncbi Impact of anesthesia on valvular function in normal rats during echocardiography
    Steven Droogmans
    Department of Cardiology, UZ Brussel, Belgium
    Ultrasound Med Biol 34:1564-72. 2008
    ..In conclusion, anesthesia causes hemodynamic changes that may result in functional valvular regurgitations in normal rats...
  79. ncbi 64-MDCT for diagnosis of aortic regurgitation in patients referred to CT coronary angiography
    Gudrun M Feuchtner
    Clinical Department of Radiology II, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    AJR Am J Roentgenol 191:W1-7. 2008
    ..Therefore, the purpose of this study was to evaluate whether aortic valve regurgitation can be diagnosed with 64-MDCT in comparison with transthoracic echocardiography...
  80. ncbi Quadricuspid aortic valve: a rare cause of aortic regurgitation and stenosis
    Selman Vefa Yildirim
    Division of Pediatric Cardiology, Baskent University, Adana Training and Medical Research Center, Adana, Turkey
    Turk J Pediatr 50:500-2. 2008
    ..The patient was diagnosed as having a quadricuspid aortic valve associated with aortic regurgitation, severe aortic stenosis, and an ascending aortic aneurysm...
  81. ncbi Mid-term results of freestyle aortic stentless bioprosthetic valve: clinical impact of quantitative analysis of in-vivo three-dimensional flow velocity profile by magnetic resonance imaging
    Hajime Matsue
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Suita, Japan
    J Heart Valve Dis 14:630-6. 2005
    ..The study aim was to investigate the in-vivo flow profiles of a stentless aortic bioprosthetic valve by MRI flow quantification, and to identify the clinical implication of prosthesis size and implantation method...
  82. ncbi Doppler echocardiographic assessment of valvular regurgitation severity by measurement of the vena contracta: an in vitro validation study
    Julia Mascherbauer
    Department of Cardiology, Vienna General Hospital, University of Vienna, Vienna, Austria
    J Am Soc Echocardiogr 18:999-1006. 2005
    ..Measurements of the vena contracta (VC) by color Doppler echocardiography have been proposed but limited data are available on the actual accuracy of this method...
  83. ncbi Assessment of aortic regurgitation by live three-dimensional transthoracic echocardiographic measurements of vena contracta area: usefulness and validation
    Ligang Fang
    Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Echocardiography 22:775-81. 2005
    ..95), with improved dispersion between angiographic grades demonstrated by the 3D TTE technique. Live 3D TTE color Doppler measurements of VCA can be used for accurate assessment of AR and are comparable to assessment by aortography...
  84. ncbi Impact of prosthesis-patient size on functional recovery after aortic valve replacement
    Colleen Gorman Koch
    Department of Cardiothoracic Anesthesia, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 111:3221-9. 2005
    ..Our objectives were to examine the impact of valve replacement, continuous prosthesis-patient size, and other factors on functional recovery after aortic valve replacement (AVR) with the Duke Activity Status Index (DASI)...
  85. ncbi Measurement of aortic valve anatomic regurgitant area using transesophageal echocardiography: implications for the quantitation of aortic regurgitation
    Mehmet Ozkan
    Kosuyolu Heart and Research Hospital, Istanbul, Turkey
    J Am Soc Echocardiogr 15:1170-4. 2002
    ..Various echocardiographic methods for the assessment of the severity of the aortic regurgitation (AR) by have been described with no general consensus...
  86. ncbi Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents
    K E Volmar
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Arch Pathol Lab Med 125:1555-61. 2001
    ..Few published studies of the pathology of fenfluramine-phentermine (fen-phen) valvulopathy, described by Connolly and colleagues in 1997, have appeared...
  87. ncbi Evaluation of effective aortic regurgitant orifice area and its effect on aortic regurgitant volume with Doppler echocardiography
    K Mizushige
    Second Department of Internal Medicine, Kagawa Medical University, Japan
    Angiology 51:241-6. 2000
    ..The values of ROA by the two methods showed a good correlation (r = 0.93, p < 0.001). Thus, the authors conclude that the ROA is a basic determinant of the RV in AR and that color Doppler can be employed to precisely assess the ROA...
  88. ncbi Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities
    J G Jollis
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 101:2071-7. 2000
    ..The prevalence and clinical significance of regurgitation among patients treated with these medications has yet to be fully established...
  89. ncbi Clinical and echocardiographic follow-up of patients previously treated with dexfenfluramine or phentermine/fenfluramine
    J M Gardin
    Division of Cardiology, St John Hospital and Medical Center, 22201 Moross Rd, PB II, Suite 470, Detroit, MI 48236, USA
    JAMA 286:2011-4. 2001
    ..Use of anorexigen therapy is associated with valvular abnormalities, although there is limited information on long-term changes in valvular regurgitation following discontinuation of these agents...
  90. ncbi Determination of vena contracta and its value in evaluating severity of aortic regurgitation
    Mehmet Eren
    Siyami Ersek Thoracic and Cardiovascular Surgery Center, Cardiology Department, Istanbul, Turkey
    J Heart Valve Dis 11:567-75. 2002
    ..The study aim was to quantify aortic regurgitation (AR) by using color Doppler imaging of the VC...
  91. ncbi Human tissue valves in aortic position: determinants of reoperation and valve regurgitation
    T P Willems
    Department of Cardiothoracic Surgery, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Circulation 103:1515-21. 2001
    ..In both techniques, progression of aortic regurgitation over time is small but accelerated in young adults...
  92. ncbi Tricuspidization of incompetent bicuspid aortic valve
    Kohei Kawazoe
    Department of Cardiovascular Surgery, Iwate Medical University Memorial Heart Center, Chuodori 1 2 1, Morioka, Iwate, Japan
    J Thorac Cardiovasc Surg 126:908-10. 2003
  93. ncbi Heart valvular disease in patients with Parkinson's disease treated with high-dose pergolide
    G Van Camp
    Department of Cardiology, Vrije Universiteit Brussels, Belgium
    Neurology 61:859-61. 2003
    ..The findings suggest a possible role of high doses of pergolide in inducing restrictive valvular disease...
  94. ncbi Eight-year results after aortic valve replacement with the Freestyle stentless bioprosthesis
    David S Bach
    Department of Medicine, Division of Cardiology, University of Michigan, Ann Arbor, 48109, USA
    J Thorac Cardiovasc Surg 127:1657-63. 2004
    ..We sought to describe the hemodynamic and clinical outcomes for the Freestyle aortic root bioprosthesis (Medtronic, Inc, Minneapolis, Minn) in a large multicenter cohort prospectively followed for 8 years...
  95. ncbi Use of pulse wave and color flow Doppler echocardiography in mouse models of human disease
    Richard D Patten
    Division of Cardiology and the Molecular Cardiology Research Institute, Department of Medicine, New England Medical Center, Boston, 02111, USA
    J Am Soc Echocardiogr 15:708-14. 2002
    ..In addition, this study indicates that these modalities may be potentially useful to screen transgenic mice for valve abnormalities...
  96. ncbi Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies
    Molly Sachdev
    Duke Clinical Research Institute and the School of Medicine, Duke University, Durham, NC, USA
    Am Heart J 144:1065-73. 2002
    ..We systematically reviewed evidence regarding the prevalence of valvular disease after fenfluramine exposure...
  97. ncbi Contemporary approach to aortic and mitral regurgitation
    Jeffrey S Borer
    Division of Cardiovascular Pathophysiology and The Howard Gilman Institute for Valvular Heart Diseases, Weill Medical College of Cornell University, New York, NY, USA
    Circulation 108:2432-8. 2003
  98. ncbi Aortic valve replacement for the asymptomatic patient with aortic regurgitation: a new piece of the strategic puzzle
    Jeffrey S Borer
    Circulation 106:2637-9. 2002
  99. ncbi Impact of implant technique following freestyle stentless aortic valve replacement
    David S Bach
    Department of Medicine, Division of Cardiology, University of Michigan, Ann Arbor, USA
    Ann Thorac Surg 74:1107-13; discussion 1113-4. 2002
    ..The purpose of the present study was to determine whether implant technique of the Freestyle aortic root bioprosthesis impacts clinical outcomes or hemodynamic performance...
  100. ncbi Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Med 112:710-5. 2002
    ..We assessed whether the use of the appetite suppressants fenfluramine/dexfenfluramine, either alone or with phentermine, was associated with aortic regurgitation while adjusting for these variables...
  101. ncbi Prevalence and determinants of valvulopathy in patients treated with dexfenfluramine
    B K Shively
    Cardiology Divisions of Oregon Health Sciences University, Portland, OR, USA
    Circulation 100:2161-7. 1999
    ..Valve regurgitation has been associated with dexfenfluramine, but its prevalence and severity are uncertain. Additional factors that may contribute to valve regurgitation in patients exposed to this drug are poorly understood...

Research Grants17

  1. Rapid Flow Evaluaton by Magnetic Resonance Imaging
    Mark Doyle; Fiscal Year: 2006
    ..Following the development stage, clinical application will be made to patients with aortic valvular diseases. ..
  2. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  3. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2008
    ..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..
  4. Genetic Basis of Aortic Aneurysms/Dissections
    Dianna Milewicz; Fiscal Year: 2009
    ..Therefore, identification of the genes that predispose individuals to TAAD is critical in preventing premature deaths due to dissections. ..
  5. Libman-Sacks Endocarditis and NPSLE
    Carlos Roldan; Fiscal Year: 2009
    ....
  6. DETERMINANTS OF PROCEDURE USE IN MYOCARDIAL INFARCTION
    James Jollis; Fiscal Year: 2003
    ..We will also examine "which rate is right?" by comparing adjusted outcomes (mortality, resource use, and costs), and by comparing procedure use to approaches based on medical evidence. ..
  7. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  8. MICROSCOPIC CARDIAC MATERIAL PROPERTIES IN AGING
    Samuel Wickline; Fiscal Year: 2002
    ....
  9. Thrombophilia In Cryptogenic Stroke (THICK) Study
    JORGE KIZER; Fiscal Year: 2006
    ..Interactions among thrombophilias, thrombophilias and traditional cardiovascular risk factors, and thrombophilias and other potential cardiac sources of embolism will also be investigated. ..
  10. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007
    ..abstract_text> ..
  11. Targeting MMPS to Image Atherosclerosis
    Jagat Narula; Fiscal Year: 2007
    ..The extent of inflammation and MMP expression in the plaques will be ascertained histopathologically. [unreadable] (End of Abstract) [unreadable] [unreadable] [unreadable]..
  12. SPECIFIC TISSUE TARGETED ULTRASONIC CONTRAST AGENT
    Samuel Wickline; Fiscal Year: 2002
    ....
  13. CHARACTERIZING MICROFIBRIL ABNORMALITIES IN SCLERODERMA
    Dianna Milewicz; Fiscal Year: 2003
    ..The research proposed in this grant will determine the contribution of abnormalities in fibrillin-1-containing microfibrils to the activation of fibroblasts, which leads to the fibrosis that characterizes SSc. ..
  14. ULTRASONIC TISSUE CHARACTERIZATION OF CARDIAC REMODELING
    Samuel Wickline; Fiscal Year: 2004
    ....
  15. ANGIOTENSIN-II BLOCKADE IN MITRAL REGURGITATION
    Maurice Enriquez Sarano; Fiscal Year: 2004
    ..The results of this clinical trial should provide strong evidence regarding medical treatment of patients with organic MR and define future strategies to minimize mortality and morbidity of organic MR. ..
  16. Imaging Apoptosis to Detect Unstable Atheromatous Plaque
    Jagat Narula; Fiscal Year: 2004
    ..The impending surgical intervention will allow histopathological evaluation of the endarterectomy specimens to define potential utility of annexin imaging. ..
  17. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..The final phase will study mechanisms of vascular protection afforded by aprotinin. The proposed study has the potential to reduce the risk of brain injury in children and adults undergoing heart surgery. ..