heart arrest

Summary

Summary: Cessation of the heart beat.

Top Publications

  1. pmc Regional variation in out-of-hospital cardiac arrest incidence and outcome
    Graham Nichol
    Department of Biostatistics, University of Washington Clinical Trial Center, Seattle, WA, USA
    JAMA 300:1423-31. 2008
  2. ncbi Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resusci
    Ian Jacobs
    Circulation 110:3385-97. 2004
  3. ncbi Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis
    Comilla Sasson
    Departments of Emergency Medicine and Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Circ Cardiovasc Qual Outcomes 3:63-81. 2010
  4. ncbi Quality of cardiopulmonary resuscitation during out-of-hospital cardiac arrest
    Lars Wik
    National Competence Center for Emergency Medicine, Ulleval University Hospital, Oslo, Norway
    JAMA 293:299-304. 2005
  5. ncbi Hypothermia after cardiac arrest should be further evaluated--a systematic review of randomised trials with meta-analysis and trial sequential analysis
    Niklas Nielsen
    Department of Clinical Sciences, Section of Anesthesia and Intensive Care, Lund University, S 221 85 Lund, Sweden
    Int J Cardiol 151:333-41. 2011
  6. pmc Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation
    Jim Christenson
    MSc, Emergency and Health Services Commission of British Columbia, 302 2955 Virtual Way, Vancouver, British Columbia, Canada V5M 4X6
    Circulation 120:1241-7. 2009
  7. ncbi Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis
    Yih Sharng Chen
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Lancet 372:554-61. 2008
  8. ncbi Estimating effectiveness of cardiac arrest interventions: a logistic regression survival model
    T D Valenzuela
    Department of Surgery, University of Arizona, Tucson, USA
    Circulation 96:3308-13. 1997
  9. ncbi Chest compression rates during cardiopulmonary resuscitation are suboptimal: a prospective study during in-hospital cardiac arrest
    Benjamin S Abella
    Emergency Resuscitation Center and Section of Emergency Medicine, University of Chicago Hospitals, Chicago, Ill 60637, USA
    Circulation 111:428-34. 2005
  10. ncbi CPR training and CPR performance: do CPR-trained bystanders perform CPR?
    Robert Swor
    Department of Emergency Medicine, Royal Oak William Beaumont Hospital, Royal Oak, MI, USA
    Acad Emerg Med 13:596-601. 2006

Research Grants

Detail Information

Publications290 found, 100 shown here

  1. pmc Regional variation in out-of-hospital cardiac arrest incidence and outcome
    Graham Nichol
    Department of Biostatistics, University of Washington Clinical Trial Center, Seattle, WA, USA
    JAMA 300:1423-31. 2008
    ..The health and policy implications of regional variation in incidence and outcome of out-of-hospital cardiac arrest remain to be determined...
  2. ncbi Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resusci
    Ian Jacobs
    Circulation 110:3385-97. 2004
    ..Uniform collection and tracking of registry data should enable better continuous quality improvement within every hospital, emergency medical services system, and community...
  3. ncbi Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis
    Comilla Sasson
    Departments of Emergency Medicine and Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Circ Cardiovasc Qual Outcomes 3:63-81. 2010
    ..We also examined trends in OHCA survival over time...
  4. ncbi Quality of cardiopulmonary resuscitation during out-of-hospital cardiac arrest
    Lars Wik
    National Competence Center for Emergency Medicine, Ulleval University Hospital, Oslo, Norway
    JAMA 293:299-304. 2005
    ..There is little information on adherence to these guidelines during advanced cardiac life support in the field...
  5. ncbi Hypothermia after cardiac arrest should be further evaluated--a systematic review of randomised trials with meta-analysis and trial sequential analysis
    Niklas Nielsen
    Department of Clinical Sciences, Section of Anesthesia and Intensive Care, Lund University, S 221 85 Lund, Sweden
    Int J Cardiol 151:333-41. 2011
    ..Our objective was to systematically evaluate the evidence for MIH taking into consideration the risks of systematic and random error and to GRADE the evidence...
  6. pmc Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation
    Jim Christenson
    MSc, Emergency and Health Services Commission of British Columbia, 302 2955 Virtual Way, Vancouver, British Columbia, Canada V5M 4X6
    Circulation 120:1241-7. 2009
    ....
  7. ncbi Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis
    Yih Sharng Chen
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Lancet 372:554-61. 2008
    ..We aimed to assess whether extracorporeal CPR was better than conventional CPR for patients with in-hospital cardiac arrest of cardiac origin...
  8. ncbi Estimating effectiveness of cardiac arrest interventions: a logistic regression survival model
    T D Valenzuela
    Department of Surgery, University of Arizona, Tucson, USA
    Circulation 96:3308-13. 1997
    ..The study objective was to develop a simple, generalizable predictive model for survival after out-of-hospital cardiac arrest due to ventricular fibrillation...
  9. ncbi Chest compression rates during cardiopulmonary resuscitation are suboptimal: a prospective study during in-hospital cardiac arrest
    Benjamin S Abella
    Emergency Resuscitation Center and Section of Emergency Medicine, University of Chicago Hospitals, Chicago, Ill 60637, USA
    Circulation 111:428-34. 2005
    ..We sought to measure in-hospital chest compression rates and to determine compliance with published international guidelines...
  10. ncbi CPR training and CPR performance: do CPR-trained bystanders perform CPR?
    Robert Swor
    Department of Emergency Medicine, Royal Oak William Beaumont Hospital, Royal Oak, MI, USA
    Acad Emerg Med 13:596-601. 2006
    ..To determine factors associated with cardiopulmonary resuscitation (CPR) provision by CPR-trained bystanders and to determine factors associated with CPR performance by trained bystanders...
  11. ncbi Predicting neurological outcome after cardiac arrest
    Mauro Oddo
    Department of Intensive Care Medicine, Neurology Service, Centre Hospitalier Universitaire Vaudois, University Hospital, Faculty of Biology and Medicine, Lausanne, Switzerland
    Curr Opin Crit Care 17:254-9. 2011
    ..However, therapeutic hypothermia alters prognostic accuracy. Parameters for outcome prediction, validated by the American Academy of Neurology before the introduction of therapeutic hypothermia, need further update...
  12. ncbi Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest
    Xian Fei Ji
    Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China
    Resuscitation 81:1031-6. 2010
    ..To compare the efficacy of nifekalant and amiodarone in the treatment of cardiac arrest in a porcine model...
  13. ncbi Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies
    Jocelyn Berdowski
    Department of Cardiology, Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands
    Resuscitation 81:1479-87. 2010
    ..The aim of this investigation was to estimate and contrast the global incidence and outcome of out-of-hospital cardiac arrest (OHCA) to provide a better understanding of the variability in risk and survival of OHCA...
  14. ncbi Inter-hospital variability in post-cardiac arrest mortality
    Brendan G Carr
    The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania School of Medicine UPENN SOM, USA
    Resuscitation 80:30-4. 2009
    ..We examined hospital-level variation in mortality of patients admitted to United States intensive care units (ICUs) with a diagnosis of cardiac arrest...
  15. ncbi Long-term prognosis after out-of-hospital cardiac arrest
    Tina I Horsted
    Department of Anaesthesia, Centre of Head and Orthopaedics 4231, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Resuscitation 72:214-8. 2007
    ..In this study we aimed to report survival beyond 6 months, including quality of life, for patients after out-of-hospital cardiac arrest (OHCA) with a physician-based EMS in an urban area...
  16. pmc Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 21:893-901. 2010
    ..However, limited data exist regarding the efficacy and limitations of this form of medical management within high-risk subsets of these populations...
  17. ncbi Intracisternal administration of glibenclamide or 5-hydroxydecanoate does not reverse the neuroprotective effect of ketogenic diet against ischemic brain injury-induced neurodegeneration
    K K Tai
    Long Beach Memorial Medical Center, Long Beach, CA 90806, USA
    Brain Inj 23:1081-8. 2009
    ..To investigate the role of ATP-sensitive potassium (K(ATP)) channels in the neuroprotective effects of a ketogenic diet against cardiac arrest-induced cerebral ischemic brain injury-induced neurodegeneration...
  18. ncbi Assessment of BLS skills: optimizing use of instructor and manikin measures
    Bonnie Lynch
    University of Dundee School of Medicine, Dundee, Tayside Centre for General Practice, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF, United Kingdom
    Resuscitation 76:233-43. 2008
    ..Comparisons of instructors' subjective assessments with objective data from recording manikins provide one means of understanding the magnitude and type of instructor errors in assessment...
  19. ncbi Subarachnoid haemorrhage as a cause of out-of-hospital cardiac arrest: a prospective computed tomography study
    Joji Inamasu
    Department of Emergency Medicine, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan
    Resuscitation 80:977-80. 2009
    ..Early identification of SAH-induced OHCA with the use of brain computed tomography (CT) scan obtained immediately after resuscitation may help emergency physicians make therapeutic decision as quickly as they can...
  20. ncbi Cardiac arrest in schools
    Katayoun Lotfi
    Emergency Medical Services Division, Public Health Seattle and King County, 401 Fifth Ave, Suite 1200, Seattle, WA 98104, USA
    Circulation 116:1374-9. 2007
    ..The purpose of the present study is to improve understanding of the epidemiology of cardiac arrest in the school setting, with a special focus on the role of school-based automated external defibrillators...
  21. ncbi Therapeutic hypothermia in Italian intensive care units: a national survey
    A Bianchin
    Anesthesia and Intensive Care Unit, Azienda ULSS 8, Hospital of Montebelluna, Treviso, Italy
    Minerva Anestesiol 75:357-62. 2009
    ..The aim of this study was to investigate the use of therapeutic hypothermia (TH) in Italian Intensive Care Units (ICUs)...
  22. ncbi "Identifying the hospitalised patient in crisis"--a consensus conference on the afferent limb of rapid response systems
    Michael A DeVita
    West Penn Allegheny Health System, Pittsburgh, PA, USA
    Resuscitation 81:375-82. 2010
    ..There is no consensus regarding how best to detect patient deterioration or a clear description of what constitutes patient monitoring...
  23. pmc Rationale, development and implementation of the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest
    Laurie J Morrison
    Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Suite C753, Toronto, Ontario, Canada M4N 3M5
    Resuscitation 78:161-9. 2008
    ..To describe the development, design and consequent scientific implications of the Resuscitation Outcomes Consortium (ROC) population-based registry; ROC Epistry-Cardiac Arrest...
  24. ncbi Quality of chest compressions during 10min of single-rescuer basic life support with different compression: ventilation ratios in a manikin model
    Conrad Arnfinn Bjørshol
    Department of Anaesthesia and Intensive Care, Division of Acute Care Medicine, Stavanger University Hospital, Stavanger, Norway
    Resuscitation 77:95-100. 2008
    ..As fatigue may reduce BLS performance over time we wanted to examine the quality of chest compressions in a single-rescuer scenario during prolonged BLS with different compression:ventilation ratios (C:V ratios)...
  25. ncbi Intestinal ischaemia during cardiac arrest and resuscitation: comparative analysis of extracellular metabolites by microdialysis
    Ulrike Korth
    Faculty of Clinical Medicine Mannheim, Institute of Anesthesiology, University of Heidelberg, 68165 Mannheim, Germany
    Resuscitation 58:209-17. 2003
    ..Comparative analysis by multi-site microdialysis reveals that the intestine is equally or even more sensitive to ischaemia than brain or muscle...
  26. ncbi Incidence, location and reasons for avoidable in-hospital cardiac arrest in a district general hospital
    Timothy J Hodgetts
    Royal Centre for Defence Medicine, Selly Oak Hospital, Birmingham B29 6 JD, UK
    Resuscitation 54:115-23. 2002
    ..To establish how location and individual or system factors influence avoidable cardiac arrest in order to develop an evidence-based preventive strategy...
  27. pmc Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 4:e7588. 2009
    ..This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postconditioning are cardioprotective in a model of cardiopulmonary resuscitation following acute myocardial ischemia...
  28. ncbi Improving in-hospital cardiac arrest process and outcomes with performance debriefing
    Dana P Edelson
    Section of General Internal Medicine, University of Chicago, Chicago, Illinois, USA
    Arch Intern Med 168:1063-9. 2008
    ....
  29. ncbi Incidence of EMS-treated out-of-hospital cardiac arrest in Europe
    Christie Atwood
    School of Medicine, University of Washington, Seattle, WA 98104, USA
    Resuscitation 67:75-80. 2005
    ..The aim of the investigation was to determine a representative European incidence and survival from cardiac arrest in all-rhythms and in ventricular fibrillation treated by the emergency medical services (EMS)...
  30. ncbi Education in resuscitation: an ILCOR symposium: Utstein Abbey: Stavanger, Norway: June 22-24, 2001
    Douglas A Chamberlain
    Circulation 108:2575-94. 2003
  31. pmc Characteristics and outcome among patients having out of hospital cardiac arrest at home compared with elsewhere
    J Herlitz
    Division of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Heart 88:579-82. 2002
    ..To describe the characteristics and outcome of patients who have a cardiac arrest at home compared with elsewhere out of hospital...
  32. ncbi Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion
    R J Litz
    Department of Anaesthesiology and Intensive Care Medicine, Fetscher Str 74, University Hospital Dresden, 01307 Dresden, Germany
    Anaesthesia 61:800-1. 2006
    ..This case shows that lipid infusion may have a beneficial role in cases of local anaesthetic toxicity when conventional resuscitation has been unsuccessful...
  33. ncbi Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    Stephen A Bernard
    Intensive Care Unit, Dandenong Hospital, Dandenong, Australia
    N Engl J Med 346:557-63. 2002
    ..In a randomized, controlled trial, we compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest...
  34. ncbi Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation
    Pierre Yves Gueugniaud
    Service d Aide Médicale Urgente 69, Hospices Civils de Lyon, University of Lyon 1, Lyon, France
    N Engl J Med 359:21-30. 2008
    ....
  35. ncbi Manual chest compression vs use of an automated chest compression device during resuscitation following out-of-hospital cardiac arrest: a randomized trial
    Al Hallstrom
    Department of Biostatistics, University of Washington, Seattle, WA 98105, USA
    JAMA 295:2620-8. 2006
    ..Compared with manual chest compression, an automated load-distributing band (LDB) chest compression device produces greater blood flow to vital organs and may improve resuscitation outcomes...
  36. ncbi Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial
    Theresa M Olasveengen
    Institute for Experimental Medical Research, Oslo University Hospital, Ullevaal, N 0407 Oslo, Norway
    JAMA 302:2222-9. 2009
    ....
  37. ncbi The impact of a new CPR assist device on rate of return of spontaneous circulation in out-of-hospital cardiac arrest
    Michael Casner
    San Francisco Fire Department, San Francisco, California 94107, USA
    Prehosp Emerg Care 9:61-7. 2005
    ..A retrospective chart review was undertaken to determine whether the AutoPulse had altered short-term patient outcome, specifically, return of spontaneous circulation (ROSC)...
  38. ncbi Value of debriefing during simulated crisis management: oral versus video-assisted oral feedback
    Georges L Savoldelli
    St Michael s Anesthesia Research into Teaching Simulation Group, Department of Anesthesia, St Michael s Hospital, University of Toronto, Ontario, Canada
    Anesthesiology 105:279-85. 2006
    ....
  39. ncbi Public use of automated external defibrillators
    Sherry L Caffrey
    City of Chicago Department of Aviation, O Hare International Airport, Chicago, IL 60666, USA
    N Engl J Med 347:1242-7. 2002
    ..We performed a two-year prospective study at three Chicago airports to assess whether random bystanders witnessing out-of-hospital cardiac arrests would retrieve and successfully use automated external defibrillators...
  40. ncbi Use of an automated, load-distributing band chest compression device for out-of-hospital cardiac arrest resuscitation
    Marcus Eng Hock Ong
    Department of Epidemiology and Community Health, Virginia Commonwealth University, Richmond, USA
    JAMA 295:2629-37. 2006
    ..Only 1% to 8% of adults with out-of-hospital cardiac arrest survive to hospital discharge...
  41. ncbi Cardiac arrests associated with hyperkalemia during red blood cell transfusion: a case series
    Hugh M Smith
    Department of Anesthesiology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Anesth Analg 106:1062-9, table of contents. 2008
    ..We examined the clinical scenarios and outcomes of patients who developed hyperkalemia and cardiac arrest during rapid RBC transfusion...
  42. ncbi Quality of out-of-hospital cardiopulmonary resuscitation with real time automated feedback: a prospective interventional study
    Jo Kramer-Johansen
    Institute for Experimental Medical Research, University of Oslo, N 0407 Oslo, Norway
    Resuscitation 71:283-92. 2006
    ..To compare quality of CPR during out-of-hospital cardiac arrest with and without automated feedback...
  43. ncbi Emergency percutaneous coronary intervention in patients with ST-elevation myocardial infarction complicated by out-of-hospital cardiac arrest: early and medium-term outcome
    Corrado Lettieri
    Department of Cardiology, Ospedale Carlo Poma, Mantova, Italy
    Am Heart J 157:569-575.e1. 2009
    ..The aim of this study was to evaluate the in-hospital and postdischarge outcomes of STEMI patients surviving OHCA and undergoing emergency angioplasty (percutaneous coronary intervention [PCI]) within an established regional network...
  44. ncbi Anxiety, depression, and PTSD following cardiac arrest: a systematic review of the literature
    Kathryn P Wilder Schaaf
    Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA 23298 0542, USA
    Resuscitation 84:873-7. 2013
    ..Identify the occurrence rate of post-arrest psychological distress; evaluate methodological approaches; suggest future research priorities; address clinical implications...
  45. ncbi Ketogenic diet prevents cardiac arrest-induced cerebral ischemic neurodegeneration
    K K Tai
    The Parkinson s and Movement Disorder Research Laboratory, Long Beach Memorial Medical Center, 2625 Pasadena Ave, Long Beach, CA, USA
    J Neural Transm 115:1011-7. 2008
    ..The results demonstrate that KD can prevent cardiac arrest-induced cerebral ischemic neurodegeneration in selected brain regions...
  46. ncbi Determinants of quality of life in survivors of cardiac arrest
    Véronique R M P Moulaert
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Rehabil Med 42:553-8. 2010
    ..To study factors related to quality of life after a hypoxic period due to cardiac arrest...
  47. ncbi A comparison of 2 types of chest compressions in a porcine model of cardiac arrest
    Jun Yuan Wu
    Emergency Department, affiliated Chao Yang Hospital of Capital Medical University, Chao Yang District, Beijing 100020, China
    Am J Emerg Med 27:823-9. 2009
    ..This study was designed to compare the effects of these clinical quality chest compressions with standard manual chest compressions in a porcine model of cardiac arrest...
  48. ncbi Validation of a rule for termination of resuscitation in out-of-hospital cardiac arrest
    Laurie J Morrison
    Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ont, Canada
    N Engl J Med 355:478-87. 2006
    ..Otherwise, the rule recommends transportation to the hospital, in accordance with routine practice...
  49. pmc Post-cardiac arrest temperature manipulation alters early EEG bursting in rats
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 78:367-73. 2008
    ..EEG recovers through periodic bursting from isoelectricity after CA, the duration of which is associated with outcome in normothermia. We quantified burst frequency to study the effect of temperature on early EEG recovery after CA...
  50. ncbi Intraoperative thrombolysis in a patient with cardiopulmonary arrest undergoing caesarean delivery
    M Wenk
    Department of Anesthesiology and Intensive Care, St Franziskus Hospital Muenster, Muenster, Germany
    Anaesth Intensive Care 39:671-4. 2011
    ..The patient survived and was later discharged without any major neurological deficit...
  51. pmc Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors
    Greg J Norman
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 31:3446-52. 2011
    ..Furthermore, we provide evidence that pharmacological activation of α7 nicotinic acetylcholine receptors provide significant protection against ischemia-related cell death and inflammation within a clinically relevant time frame...
  52. pmc Trends in survival after in-hospital cardiac arrest
    Saket Girotra
    University of Iowa Hospitals and Clinics, Department of Internal Medicine, Division of Cardiovascular Diseases, 200 Hawkins Dr, Suite 4430 RCP, Iowa City, IA 52242, USA
    N Engl J Med 367:1912-20. 2012
    ..Despite advances in resuscitation care in recent years, it is not clear whether survival and neurologic function after in-hospital cardiac arrest have improved over time...
  53. pmc Management of brain injury after resuscitation from cardiac arrest
    Romergryko G Geocadin
    Neurosciences Critical Care Division, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurol Clin 26:487-506, ix. 2008
    ....
  54. ncbi Postresuscitation myocardial dysfunction: correlated factors and prognostic implications
    Wei Tien Chang
    Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Chung Shan South Road 7, 100, Taipei, Taiwan, R O C
    Intensive Care Med 33:88-95. 2007
    ..To evaluate the clinical factors correlated with postresuscitation myocardial dysfunction and the prognostic implication such dysfunction may have...
  55. ncbi Molecular mechanisms of therapeutic hypothermia on neurological function in a swine model of cardiopulmonary resuscitation
    Hong Zhao
    Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Resuscitation 83:913-20. 2012
    ..To explore the molecular mechanisms by which mild hypothermia following resuscitation improves neurological function in a porcine model of cardiac arrest...
  56. ncbi Effects of therapeutic hypothermia on coagulopathy and microcirculation after cardiopulmonary resuscitation in rabbits
    Hu Chun-Lin
    Department of Emergency Medicine, Sun Yat Sen University, Guangzhou 510080, China
    Am J Emerg Med 29:1103-10. 2011
    ..The aim of this study was to investigate the effects of therapeutic hypothermia (TH) on coagulopathy and cerebral microcirculation disorder after cardiopulmonary resuscitation (CPR) in rabbits...
  57. pmc Incidence of treated cardiac arrest in hospitalized patients in the United States
    Raina M Merchant
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 39:2401-6. 2011
    ..The incidence and incidence over time of cardiac arrest in hospitalized patients is unknown. We sought to estimate the event rate and temporal trends of adult inhospital cardiac arrest treated with a resuscitation response...
  58. pmc Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation
    Michael P Hutchens
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, United States
    Resuscitation 76:89-94. 2008
    ..0001 versus WT). We conclude that sEH plays an important role in cardiovascular regulation, and that reduced sEH levels or function reduces survival from cardiac arrest...
  59. ncbi Shen-fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest
    Xian Fei Ji
    Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    Shock 35:530-6. 2011
    ..Shen-Fu injection can attenuate postresuscitation myocardial dysfunction through beneficial effects on energy metabolism and remarkable antioxidant capacity...
  60. ncbi Pathophysiology and pathogenesis of post-resuscitation myocardial stunning
    Athanasios Chalkias
    Department of Anatomy, Medical School, University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece
    Heart Fail Rev 17:117-28. 2012
    ..This article covers a huge gap in the existing literature regarding the pathophysiology of post-resuscitation period and provides a better understanding of the pathophysiology and pathogenesis of post-resuscitation myocardial stunning...
  61. ncbi The influence of induced hypothermia and delayed prognostication on the mode of death after cardiac arrest
    Irina Dragancea
    Department of Neurology, Skane University Hospital, Lund, Sweden
    Resuscitation 84:337-42. 2013
    ..Induced hypothermia is recommended as neuroprotective treatment after (CA) but may affect prognostic parameters. We evaluated the effect of delayed neurological prognostication on the mode of death in hypothermia-treated CA-survivors...
  62. ncbi Effect of continuous compressions and 30:2 cardiopulmonary resuscitation on global ventilation/perfusion values during resuscitation in a porcine model
    Shuo Wang
    Department of Emergency Medicine, Beijing Chaoyang Hospital affiliated with Capital Medical University, Beijing, China
    Crit Care Med 38:2024-30. 2010
    ....
  63. ncbi Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions
    Adriana Miclescu
    Department of Surgical Sciences Anaesthesiology and Critical Care Medicine, Uppsala University, Uppsala, Sweden
    Crit Care Med 38:2199-206. 2010
    ....
  64. ncbi Nitrotyrosine and nitrate/nitrite levels in cardiac arrest survivors treated with endovascular hypothermia
    A Kruger
    Cardiovascular Center, Department of Cardiology, Na Homolce Hospital, Prague, Czech Republic
    Physiol Res 61:425-30. 2012
    ..These data suggest that attenuation of OS and NO production may be involved in the protective effect of hypothermia in adult CAS...
  65. ncbi Changing incidence of out-of-hospital ventricular fibrillation, 1980-2000
    Leonard A Cobb
    Department of Medicine, University of Washington and Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    JAMA 288:3008-13. 2002
    ..Recent reports from 2 European cities and an earlier observation from Seattle, Wash, suggest that the number of patients treated for out-of-hospital ventricular fibrillation (VF) has declined...
  66. ncbi Cardiac arrests and deaths associated with malignant hyperthermia in north america from 1987 to 2006: a report from the north american malignant hyperthermia registry of the malignant hyperthermia association of the United States
    Marilyn Green Larach
    The North American Malignant Hyperthermia Registry, Pittsburgh, Pennsylvania, USA
    Anesthesiology 108:603-11. 2008
    ....
  67. ncbi Adherence to resuscitation guidelines during prehospital care of cardiac arrest patients
    Hetti Kirves
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, 00029 HUS, Helsinki, Finland
    Eur J Emerg Med 14:75-81. 2007
    ..This study describes adherence to the resuscitation guidelines, factors associated with poor adherence and possible impact of prehospital postresuscitation care on the outcome of out-of-hospital cardiac arrest...
  68. ncbi Good outcome in every fourth resuscitation attempt is achievable--an Utstein template report from the Stavanger region
    Thomas Werner Lindner
    Department of Anaesthesiology and Intensive Care, Stavanger University Hospital, Norway
    Resuscitation 82:1508-13. 2011
    ..Out-of-hospital cardiac arrest (OHCA) is a major cause of death in the western world. We wanted to study changes in survival over time and factors linked to this in a region which have already reported high survival rates...
  69. ncbi Adverse hemodynamic effects of interrupting chest compressions for rescue breathing during cardiopulmonary resuscitation for ventricular fibrillation cardiac arrest
    R A Berg
    University of Arizona College of Medicine, Steele Memorial Children s Research Center, Department of Pediatrics, Sarver Heart Center, Tucson, Arizona, USA
    Circulation 104:2465-70. 2001
    ....
  70. ncbi Neuron-specific enolase correlates with other prognostic markers after cardiac arrest
    T Cronberg
    Division of Neurology, Department of Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden
    Neurology 77:623-30. 2011
    ..This prospective, observational study describes the pattern of commonly used prognostic markers in a hypothermia-treated cohort of cardiac arrest patients with prolonged coma...
  71. pmc Predictors of survival after cardiac or respiratory arrest in critical care units
    Demetrios J Kutsogiannis
    Division of Critical Care Medicine, University of Alberta, Edmonton, Alta
    CMAJ 183:1589-95. 2011
    ..We investigated survival outcomes of adults whose arrest occurred in ICUs and determined predictors of decreased survival...
  72. ncbi Advanced cardiac life support training improves long-term survival from in-hospital cardiac arrest
    Miguel Antonio Moretti
    Heart Institute INCOR at the University of Sao Paulo, Sao Paulo, Brazil
    Resuscitation 72:458-65. 2007
    ..In spite of the wide dissemination of ACLS training, it has been difficult to demonstrate improved outcome following such training...
  73. pmc Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest
    Philip E Empey
    Department of Pharmacy and Therapeutics, School of Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 40:1221-8. 2012
    ....
  74. ncbi Does hypothermia influence the predictive value of bilateral absent N20 after cardiac arrest?
    Christoph Leithner
    Department of Neurology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Neurology 74:965-9. 2010
    ..Recent evidence suggests that hypothermia treatment affects the predictive value of clinical findings in cardiac arrest patients, raising the question whether the predictive value of N20 responses has changed as well...
  75. ncbi In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival
    Claudio Sandroni
    Intensive Care Unit, Catholic University School of Medicine, Rome, Italy
    Intensive Care Med 33:237-45. 2007
    ..Review...
  76. pmc Sedation confounds outcome prediction in cardiac arrest survivors treated with hypothermia
    Edgar A Samaniego
    Stanford University School of Medicine, Stanford University Medical Center, 780 Welch Road, Suite 205, Palo Alto, CA 94304, USA
    Neurocrit Care 15:113-9. 2011
    ..Therapeutic hypothermia is commonly used in comatose survivors' post-cardiopulmonary resuscitation (CPR). It is unknown whether outcome predictors perform accurately after hypothermia treatment...
  77. ncbi Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER)
    Andrew D Krahn
    University of Western Ontario, London, Ontario, Canada
    Circulation 120:278-85. 2009
    ..Provocative testing to unmask a phenotype is often necessary to detect primary electrical disease, direct genetic testing, and perform family screening...
  78. pmc Brain stem death as the vital determinant for resumption of spontaneous circulation after cardiac arrest in rats
    Alice Y W Chang
    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, and Center for Neuroscience, National Sun Yat Sen University, Kaohsiung County, Taiwan, Republic of China
    PLoS ONE 4:e7744. 2009
    ....
  79. ncbi Perioperative cardiac arrests in children between 1988 and 2005 at a tertiary referral center: a study of 92,881 patients
    Randall P Flick
    Department of Anesthesiology, Mayo Clinic College of Medicine, MN 55905, USA
    Anesthesiology 106:226-37; quiz 413-4. 2007
    ..The objective of this study was to determine the incidence and outcome of perioperative cardiac arrest (CA) in children younger than 18 yr undergoing anesthesia for noncardiac and cardiac procedures at a tertiary care center...
  80. ncbi The chain of survival
    Jerry Nolan
    Department of Anaesthesia and Intensive Care Medicine, Royal United Hospital, Combe Park, Bath, Banes BA1 3NG, United Kingdom
    Resuscitation 71:270-1. 2006
  81. ncbi Resuscitation Guidelines 2005: does experienced nursing staff need training and how effective is it?
    Michael R Preusch
    Department of Cardiology, Angiology, Pneumology, University Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    Am J Emerg Med 28:477-84. 2010
    ..This study evaluated the need for basic life support training in nurses with emergency experience...
  82. ncbi Predictors of poor neurologic outcome in patients after cardiac arrest treated with hypothermia: a retrospective study
    Laurens L A Bisschops
    Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Resuscitation 82:696-701. 2011
    ..We determined the effect of mild therapeutic hypothermia on the validity of the currently used clinical practice parameters...
  83. ncbi Anesthesia-related cardiac arrest in children with heart disease: data from the Pediatric Perioperative Cardiac Arrest (POCA) registry
    Chandra Ramamoorthy
    Department of Anesthesiology, S tanford University School of Medicine, Stanford, California, USA
    Anesth Analg 110:1376-82. 2010
    ..From 1994 to 2005, the Pediatric Perioperative Cardiac Arrest Registry collected data on 373 anesthesia-related cardiac arrests (CAs) in children, 34% of whom had congenital or acquired heart disease (HD)...
  84. ncbi The role of hypothermia in post-cardiac arrest patients with return of spontaneous circulation: a systematic review
    James H Walters
    Intensive Care Medicine, Royal United Hospital, Bath BA1 3NG, UK
    Resuscitation 82:508-16. 2011
    ..The specific question addressed was: 'in post-cardiac arrest patients with a return of spontaneous circulation, does the induction of mild hypothermia improve morbidity or mortality when compared with usual care?'..
  85. ncbi Augmentation of tissue perfusion by a novel compression device increases neurologically intact survival in a porcine model of prolonged cardiac arrest
    Fumiaki Ikeno
    Division of Cardiovascular Medicine, Stanford University, Palo Alto, CA, USA
    Resuscitation 68:109-18. 2006
    ..This study was performed to determine the potential efficacy of an automated device with a load-distributing band (AutoPulse, Revivant Corporation), in improving neurologically intact survival after cardiac arrest...
  86. ncbi Changing cardiac arrest and hospital mortality rates through a medical emergency team takes time and constant review
    John Santamaria
    Department of Intensive Care Unit, St Vincent s Hospital, Melbourne, Australia
    Crit Care Med 38:445-50. 2010
    ..To determine the long-term impact of a medical emergency team on survival and to assess the utility of administrative data to monitor outcomes...
  87. ncbi Evaluation of cerebral metabolism by ¹H-magnetic resonance spectroscopy for 4°C saline-induced therapeutic hypothermia in pig model of cardiac arrest
    Zhiyu Su
    Emergency Department, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Am J Emerg Med 29:913-21. 2011
    ..In this study, we aim to evaluate hypothermia-induced changes in pigs' cerebral metabolism by (1)H-magnetic resonance spectroscopy (¹H-MRS)...
  88. ncbi Pre-hospital cardiac arrest in Prague, Czech Republic--the Utstein-style report
    Ondrej Franek
    EMS Prague, Korunní 98, Prague 10, Czech Republic
    Resuscitation 81:831-5. 2010
    ..This study aimed to report results of pre-hospital cardiopulmonary resuscitation (CPR) in the city of Prague in accordance with 'Utstein-style' recommendations...
  89. ncbi Development of a formative assessment tool for measurement of performance in multi-professional resuscitation teams
    Peter Oluf Andersen
    Danish Institute for Medical Simulation, Herlev Hospital, Capital Region of Denmark, Denmark
    Resuscitation 81:703-11. 2010
    ....
  90. pmc Rescuer fatigue during actual in-hospital cardiopulmonary resuscitation with audiovisual feedback: a prospective multicenter study
    Noah T Sugerman
    Department of Emergency Medicine, Center for Resuscitation Science, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Resuscitation 80:981-4. 2009
    ....
  91. ncbi Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia
    Tuomas Oksanen
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
    Resuscitation 80:165-70. 2009
    ....
  92. pmc Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death
    Viktoria Vereczki
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Cereb Blood Flow Metab 26:821-35. 2006
    ..Moreover, these findings indicate the need for clinical trials comparing the effects of different ventilatory oxygen levels on neurologic outcome after cardiac arrest...
  93. ncbi Circulatory arrest as a model for studies of global ischemic injury and neuroprotection
    Lars Wiklund
    Department of Surgical Sciences Anesthesiology and Intensive Care Medicine, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Ann N Y Acad Sci 1053:205-19. 2005
    ..These observations suggest that our model can be used to explore neuroprotective effects of potential therapeutic agents...
  94. ncbi High dose versus standard dose epinephrine in cardiac arrest - a meta-analysis
    C Vandycke
    Department of Emergency Medicine, AZ St Jan, Brugge, Belgium
    Resuscitation 45:161-6. 2000
    ..The possibility that patients who have already sustained irreversible neurologic injury will be resuscitated carries potential adverse social and economic implications...
  95. ncbi Long-term prognosis after out-of-hospital cardiac arrest and primary percutaneous coronary intervention
    B Bendz
    Department of Cardiology, Ulleval University Hospital, N 0407 Oslo, Norway
    Resuscitation 63:49-53. 2004
    ....
  96. pmc Hypothermia as a cytoprotective strategy in ischemic tissue injury
    Xian N Tang
    Department of Neurology, University of California, San Francisco, CA 94121, USA
    Ageing Res Rev 9:61-8. 2010
    ..This review will discuss the application of hypothermia especially as it pertains to its effects neurological outcome, cooling methods, and important parameters in optimizing hypothermic protection...
  97. ncbi Identifying non-technical skills and barriers for improvement of teamwork in cardiac arrest teams
    Peter Oluf Andersen
    Danish Institute for Medical Simulation, Herlev Hospital, Capital Region of Denmark, Denmark
    Resuscitation 81:695-702. 2010
    ..The aim of this study was to identify NTSs suitable for improving team performance in multi-professional cardiac arrest teams, and to describe barriers to the use and implementation of such NTSs by using a qualitative method...
  98. ncbi Outcomes of chest compression only CPR versus conventional CPR conducted by lay people in patients with out of hospital cardiopulmonary arrest witnessed by bystanders: nationwide population based observational study
    Toshio Ogawa
    Nara Medical University School of Medicine, Department of Public Health, Health Management and Policy, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    BMJ 342:c7106. 2011
    ..To compare the effectiveness of cardiopulmonary resuscitation (CPR) with chest compression only and conventional CPR on outcomes after cardiopulmonary arrest out of hospital...
  99. ncbi Early direct coronary angioplasty in survivors of out-of-hospital cardiac arrest
    Paul C Keelan
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Cardiol 91:1461-3, A6. 2003
  100. ncbi Neurologic preservation by Na+-H+ exchange inhibition prior to 90 minutes of hypothermic circulatory arrest
    Manuel Castella
    Department of Surgery, Division of Cardiothoracic Surgery, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
    Ann Thorac Surg 79:646-54; discussion 646-54. 2005
    ..The effects of pretreatment with cariporide (HOE 642 Aventis Pharma, Strasbourg-Cedex, France), a Na+-H+ exchanger (NHE) blocker, were studied in a cerebral ischemia-reperfusion model of hypothermic arrest...
  101. ncbi Dispatcher assisted CPR: implementation and potential benefit. A 12-year study
    Alfred P Hallstrom
    Department of Biostatistics, Clinical Trial Center, University of Washington, 1107 N E 45th St, Suite 505, Seattle, WA 98105 4689, USA
    Resuscitation 57:123-9. 2003
    ....

Research Grants63

  1. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2007
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. [unreadable] [unreadable]..
  2. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2008
    ..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..
  3. BRAIN ISCHEMIA AND MAP KINASE ACTIVATION
    Clifton Callaway; Fiscal Year: 2003
    ..The conduct of this project will provide extensive opportunities for collaboration with other basic scientists at the University of Pittsburgh, and promote the candidate's growth as an independent researcher. ..
  4. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2005
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  5. OPTIMAL PREHOSPITAL CARE OF CHILDHOOD CARDIAC ARREST
    Ian Stiell; Fiscal Year: 2004
    ..The PIs propose to conduct a large feasibility review in five urban areas and to conduct four study planning workshops. ..
  6. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  7. INSULIN RECEPTOR SUBSTRATE -1 AND FLUID SHEAR STRESS
    Francis Kim; Fiscal Year: 2005
    ..To further characterize this potential link between insulin and NO signaling. Specific Aim 3: Characterize FSS dependent signaling elements which associate with IRS-1...
  8. IKKBeta Mediated Impairment of Endothelial Nitric Oxide Production
    Francis Kim; Fiscal Year: 2010
    ..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
  9. TZD Treatment of Cocaine Toxicity
    Guy Weinberg; Fiscal Year: 2005
    ..We will also establish an isolated heart model to study the potential for clinical application of TZDs to treat acute cocaine cardiac toxicity. ..
  10. Transducer for indirect blood pressure& O2 saturation
    Leslie Geddes; Fiscal Year: 2005
    ..The neonatologist, the premature infant physician and the small-infant pediatrician have no single instrument that provides all of these vital signs. ..
  11. Calpain mediated injury in post ischemic neurons
    ROBERT NEUMAR; Fiscal Year: 2008
    ..The results will provide fundamental insights into the mechanism of delayed post-ischemic neuronal necrosis, and facilitate the development of effective therapies for patients suffering from cardiac arrest and stroke. ..
  12. Field Measures of Functional Tasks for CIT Intervention
    Paolo Bonato; Fiscal Year: 2006
    ..They will remotely monitor functional upper limb use outside the clinic in the homes and in the community of patients undergoing CIT. ..
  13. CARDIAC MAPPING OF VENTRICULAR DEFIBRILLATION
    Raymond Ideker; Fiscal Year: 2006
    ..It is hoped that the basic knowledge gained about defibrillation mechanisms through these studies will lead to the improvement of defibrillation in patients. ..
  14. Separation of brain glial and neuronal mitochondria
    Tibor Kristian; Fiscal Year: 2006
    ..As a control, mitochondria isolated from pure primary neuronal and astrocytic cell culture obtained from transgenic animals will be employed. Cell mitochondria will be isolated by using a new technique of nitrogen cavitation. ..
  15. Cardiac care in specialty and general hospitals
    Peter M Cram; Fiscal Year: 2010
    ..Together these analyses will provide much needed information on the relative quality of care provided by specialty cardiac hospitals to policy makers, payors, providers and patients. ..
  16. Buprenorphine Maintenance for Opioid Addicted Persons in Jail and Post-Release
    Stephen Magura; Fiscal Year: 2007
    ..Outcomes will be assessed at 6 months after release from jail by chart review, personal interviews and toxicologies for drugs of abuse. [unreadable] [unreadable]..
  17. Ecological Approaches to Understanding Post-Disaster Distress
    Sandro Galea; Fiscal Year: 2008
    ..Key hypotheses will be tested using multi-level hierarchical models and ecologic analyses. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. Novel device for improving standard CPR outcomes
    Keith Lurie; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. Data Mining Based Noninvasive Intracranial Pressure Assessment
    Xiao Hu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Physiology of Prolonged Ventricular Fibrillation
    JAMES MENEGAZZI; Fiscal Year: 2008
    ..These studies are novel because they will use a recently discovered, clinically available indicator (the ScE) in a model that will also allow examination of resuscitation outcomes. ..
  21. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..abstract_text> ..
  22. INNOVATIVE JOB PLACEMENT MODEL FOR METHADONE PATIENTS
    Stephen Magura; Fiscal Year: 2004
    ..4) To conduct benefit-cost and cost-effectiveness analyses of the modified IPS vocational rehabilitation program. ..
  23. THROMBOGENIC FACTORS AND RECURRENT CORONARY EVENTS
    Arthur Moss; Fiscal Year: 2003
    ..abstract_text> ..
  24. EMG-BASED METHODS FOR TESTING NON-KEYBOARD IMPUT DEVICES
    Paolo Bonato; Fiscal Year: 2002
    ..Future studies by the applicant will focus on utilizing the innovation to gain a better understanding of overuse injury mechanisms related to work tasks and the operation of devices in the workplace. ..
  25. MOLECULAR GENETIC BASIS FOR FAMILIAL ATRIAL FIBRILLATION
    RAMON BRUGADA TERRADELLAS; Fiscal Year: 2004
    ....
  26. LEVELS OF CARE AND OUTCOMES IN ALCOHOLISM TREATMENT
    Stephen Magura; Fiscal Year: 2002
    ..Using treatment cost data and outcome results, a cost-effectiveness analysis of matching and mismatching at different Levels of Care will be conducted. ..
  27. LONG QT SYNDROME--GENETIC STUDIES
    Arthur Moss; Fiscal Year: 2002
    ....
  28. GROUP MOTIVATIONAL INTERVENTION IN DRUG ABUSE TREATMENT
    Stephen Magura; Fiscal Year: 2002
    ..Because even a brief group therapy may add to treatment costs, it is important6 to determine the cost per patient for each additional unit of positive outcome achieved (assuming outcomes improve). ..
  29. PEER MENTORS FOR ADOLESCENTS IN HIV-AFFECTED FAMILIES
    Stephen Magura; Fiscal Year: 2003
    ..Primary outcomes will continue to be defined as in specific aim #1. ..
  30. Nitric Oxide/cGMP/Endotoxin-Induced Myocardial Dysfunct
    Fumito Ichinose; Fiscal Year: 2008
    ....
  31. Hsp90/Client Protein Interactions in the Newborn Lung
    Judy Aschner; Fiscal Year: 2008
    ..These studies will improve understanding of the neonatal pulmonary hypertensive response to chronic hypoxia and are critical to the formulation of novel treatment strategies for infants with PH. ..
  32. Effect of Out-of-Hospital Endotracheal Intubation Errors
    Henry Wang; Fiscal Year: 2008
    ..These analyses are innovative in the fields of EMS, patient safety and health services research and will help to justify system-wide efforts to reduce errors in this complex procedure. ..
  33. CARDIOVASCULAR RESEARCH TRAINING
    Douglas Zipes; Fiscal Year: 2003
    ..In addition, the program is ideally suited to effectively recruit under-represented minorities. We proposed to train 3 postdoctoral Fellows each year for 2 years as part of this grant. ..
  34. HEPATITIS C IN NEW IDUS: IMPLICATIONS FOR HIV PREVENTION
    Sandro Galea; Fiscal Year: 2004
    ....
  35. Clinical Research Training in Geriatric Mood Disorders
    Dan Blazer; Fiscal Year: 2008
    ..Students will be paired with a single mentor who will guide them in undertaking a focused research project. Findings will be presented at a National meeting. ..
  36. REGULATION OF PULMONARY RESISTANCE VESSELS
    Judy Aschner; Fiscal Year: 2002
    ....
  37. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
    ..The significance of this work relates to the future use of molecular therapeutics to treat ion-channel disorders associated with congenital and acquired cardiac repolarization disorders. ..
  38. Impedance Threshold Value for Improving Standard CPR
    Keith Lurie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. VENTRICULAR FIBRILLATION AND ITS ALTERATION BY PACING
    Raymond E Ideker; Fiscal Year: 2010
    ..We will test the hypotheses that pacing from the dominant domain (1) captures the maximum amount of tissue during VF and (2) halts the most organized types of VF. ..
  40. Diagnostic Utility of MRI in Intracerebral Hemorrhage
    CHRISTINE A WIJMAN; Fiscal Year: 2010
    ..We anticipate that the findings from this study will have a major impact on the management of ICH patients and will facilitate the development of practice guidelines for the use of MRI in these patients. ..
  41. Impact of sleepiness on heart failure self-care
    Barbara Riegel; Fiscal Year: 2009
    ..This study is expected to expand existing knowledge and clarify our understanding of the mechanisms linking EDS, failed self-care, poor HRQL, and unplanned hospitalizations in persons with heart failure. ..
  42. A Data Fusion Method for Bedside Monitoring of Lumped Cerebral Arterial Radii
    Xiao Hu; Fiscal Year: 2008
    ..abstract_text> ..
  43. SERVICE OUTREACH TO HOMELESS DRUG USERS
    Stephen Magura; Fiscal Year: 2003
    ..3) To determine the client characteristics and service process variables which predict entry to and retention in treatment/interventions for drug addiction, as well as other differences in outcomes. ..
  44. Control Trial of Self-Help for Dually-Diagnosed Persons
    Stephen Magura; Fiscal Year: 2005
    ..5. To conduct a process evaluation focusing on the implementation and on-going growth and development of the DTR groups (in the study clinics), as well as DTR group climate. ..
  45. Antidepressant Use by Older Adults
    Dan Blazer; Fiscal Year: 2003
    ..We will also test hypotheses specific to individual domains in the larger model. ..
  46. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith Lurie; Fiscal Year: 2006
    ..If a significant clinical benefit is demonstrated, the ITPR could become a standard piece of equipment and treatment for patients with hemorrhagic shock and traumatic brain injury. [unreadable] [unreadable]..
  47. MEDIC ONE STROKE SCALE
    David Tirschwell; Fiscal Year: 2003
    ..As stroke therapeutic research moves into the prehospital setting, the MOSS will serve as a standardized evaluation tool allowing early and accurate stroke diagnosis and severity stratification. ..
  48. NURSING INTERVENTIONS FOLLOWING SUDDEN CARDIAC ARREST
    CYNTHIA DOUGHERTY; Fiscal Year: 2001
    ..The findings are expected to be generalizable to other populations of high risk patients who leave the hospital after a very short stay, and to whom close follow-up cre by advanced practice nurses would be advantageous. ..
  49. Molecular Dissection of Melatonin Synthesis In Vivo
    Jimo Borjigin; Fiscal Year: 2003
    ....
  50. Brain Manganese Deposition in High Risk Neonates
    Judy Aschner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Exception from informed consent in pediatrics
    Marilyn Morris; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  52. STUDY PF TRANSIENT EVOKED POTENTIAL
    Nitish Thakor; Fiscal Year: 2003
    ..The long-term benefits should be improved diagnosis and novel therapeutic strategies targeted to each phase of recovery from HI injury. ..
  53. MAGNETIC RESONANCE GUIDED ELECTROPHYSIOLOGY INTERVENTION
    Henry Halperin; Fiscal Year: 2008
    ..Irvine Biomedical is supplying non-magnetic electrode catheters for use in the MRI scanner. ..
  54. HIGH RESOLUTION MRI OF MYOCARDIAL DEFORMATION
    Henry Halperin; Fiscal Year: 2001
    ....
  55. PS06-003, Opt-out HIV Testing in Emergency Dept settings
    Jason Haukoos; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  56. New Technologies in Electrophysiology Intervention
    Henry Halperin; Fiscal Year: 2005
    ..That protected time would allow him more time to pursue the patient-oriented studies outlined in this proposal, and help train young clinical investigators. ..
  57. Analysis of a Novel Family of Lipid Receptors
    Yan Xu; Fiscal Year: 2004
    ....
  58. TM Domain Structures of Ligand-Gated Ion Channels by NMR
    Yan Xu; Fiscal Year: 2007
    ..abstract_text> ..
  59. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  60. NMR STUDIES OF MECHANISMS OF GENERAL ANESTHESIA
    Yan Xu; Fiscal Year: 2003
    ..abstract_text> ..
  61. CEREBRAL PROTECTION & RECOVERY AFTER CIRCULATORY ARREST
    Yan Xu; Fiscal Year: 2007
    ..It is hoped that these specific investigations wilt pave the way to ultimately identifying the causal interaction between angiogenesis and neurogenesis after resuscitation from global ischemia. ..
  62. Planning Hypothermia Trial for Pediatric Cardiac Arrest
    Frank Moler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..