congestive heart failure

Summary

Summary: A complication of HEART DISEASES. Defective cardiac filling and/or impaired contraction and emptying, resulting in the heart's inability to pump a sufficient amount of blood to meet the needs of the body tissues or to be able to do so only with an elevated filling pressure. (from Braunwald, Heart Disease, 5th ed)

Top Publications

  1. ncbi Long-term trends in the incidence of and survival with heart failure
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    N Engl J Med 347:1397-402. 2002
  2. ncbi Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial
    Stefanie S Schleithoff
    Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany
    Am J Clin Nutr 83:754-9. 2006
  3. ncbi Family caregiving and congestive heart failure. Review and analysis
    Gerard J Molloy
    School of Psychology, University of St Andrews, St Andrews KY16 9JU, Scotland
    Eur J Heart Fail 7:592-603. 2005
  4. ncbi Insulin resistance and risk of congestive heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    JAMA 294:334-41. 2005
  5. ncbi Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
  6. ncbi Lifetime risk for developing congestive heart failure: the Framingham Heart Study
    Donald M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Circulation 106:3068-72. 2002
  7. ncbi Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    J Am Coll Cardiol 44:810-9. 2004
  8. ncbi Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (AT
    Eugene S Chung
    The Lindner Center and Ohio Heart Health Center, Cincinnati 45219, USA
    Circulation 107:3133-40. 2003
  9. ncbi Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials
    Sandra M Swain
    National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20889, USA
    Cancer 97:2869-79. 2003
  10. ncbi Impact of dialysis modality on survival of new ESRD patients with congestive heart failure in the United States
    Austin G Stack
    Division of Renal Diseases and Hypertension, Department of Internal Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Kidney Int 64:1071-9. 2003

Detail Information

Publications345 found, 100 shown here

  1. ncbi Long-term trends in the incidence of and survival with heart failure
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    N Engl J Med 347:1397-402. 2002
    ..Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized...
  2. ncbi Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial
    Stefanie S Schleithoff
    Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany
    Am J Clin Nutr 83:754-9. 2006
    Elevated circulating concentrations of proinflammatory cytokines may contribute to the pathogenesis of congestive heart failure (CHF)...
  3. ncbi Family caregiving and congestive heart failure. Review and analysis
    Gerard J Molloy
    School of Psychology, University of St Andrews, St Andrews KY16 9JU, Scotland
    Eur J Heart Fail 7:592-603. 2005
    ..In this paper, we provide a review and analysis of studies that have explicitly investigated these issues in the informal carers of CHF patients...
  4. ncbi Insulin resistance and risk of congestive heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    JAMA 294:334-41. 2005
    Diabetes and obesity are established risk factors for congestive heart failure (CHF) and are both associated with insulin resistance.
  5. ncbi Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality.
  6. ncbi Lifetime risk for developing congestive heart failure: the Framingham Heart Study
    Donald M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Circulation 106:3068-72. 2002
    b>Congestive heart failure (CHF) is an increasing public health problem.
  7. ncbi Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    J Am Coll Cardiol 44:810-9. 2004
    ..The aim of this study was to determine whether multidisciplinary strategies improve outcomes for heart failure (HF) patients...
  8. ncbi Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (AT
    Eugene S Chung
    The Lindner Center and Ohio Heart Health Center, Cincinnati 45219, USA
    Circulation 107:3133-40. 2003
    ..We evaluated the efficacy and safety of infliximab, a chimeric monoclonal antibody to TNFalpha, in patients with moderate-to-severe heart failure...
  9. ncbi Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials
    Sandra M Swain
    National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20889, USA
    Cancer 97:2869-79. 2003
    ..the cardiotoxicity of doxorubicin reported that an estimated 7% of patients developed doxorubicin-related congestive heart failure (CHF) after a cumulative dose of 550 mg/m(2)...
  10. ncbi Impact of dialysis modality on survival of new ESRD patients with congestive heart failure in the United States
    Austin G Stack
    Division of Renal Diseases and Hypertension, Department of Internal Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Kidney Int 64:1071-9. 2003
    ..hypothesized, but not proven, that peritoneal dialysis might be the optimal treatment for end-stage renal disease (ESRD) patients with established congestive heart failure (CHF) through better volume regulation compared with hemodialysis.
  11. ncbi Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
    ..It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven...
  12. ncbi Obesity and the risk of heart failure
    Satish Kenchaiah
    Framingham Heart Study, Framingham, Mass 01702, USA
    N Engl J Med 347:305-13. 2002
    ..Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk...
  13. ncbi Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support
    Michel White
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada, H1T 1C8
    Clin Sci (Lond) 110:483-9. 2006
    ..pro-inflammatory mediators and markers of oxidative stress in patients with decompensated CHF (congestive heart failure) and assessed whether clinical recompensation by short-term inotropic therapy influences these parameters...
  14. ncbi Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure
    Gust H Bardy
    Seattle Institute for Cardiac Research, Seattle, WA 98103, USA
    N Engl J Med 352:225-37. 2005
    Sudden death from cardiac causes remains a leading cause of death among patients with congestive heart failure (CHF)...
  15. ncbi Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure
    Aun Yeong Chong
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK
    J Am Coll Cardiol 43:423-8. 2004
    ..research was to test the hypothesis that plasma angiopoietin (Ang-1), its soluble receptor tie-2, and Ang-2 levels would be abnormal in patients with acute and chronic congestive heart failure (CHF) when compared with healthy controls.
  16. ncbi Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer
    Mary C Pinder
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:3808-15. 2007
    Limited data are available on long-term cardiac safety of adjuvant anthracycline chemotherapy in breast cancer patients over age 65 years. We evaluated rates and predictors of congestive heart failure (CHF) in this population.
  17. pmc Circulating adiponectin concentrations in patients with congestive heart failure
    J George
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Heart 92:1420-4. 2006
    To determine concentrations of adiponectin and its predictive value on outcome in a cohort of patients with congestive heart failure (CHF).
  18. ncbi Benefits of comprehensive inpatient education and discharge planning combined with outpatient support in elderly patients with congestive heart failure
    Cheryl Anderson
    Department of Medicine, Division of Cardiovascular Medicine, Bridgeport Hospital, Bridgeport, CT 06610, USA
    Congest Heart Fail 11:315-21. 2005
    Multidisciplinary disease management programs for congestive heart failure have been shown to substantially reduce readmission rates, resulting in a reduction of costs...
  19. ncbi Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure
    Tae Joon Cha
    5000 Belanger St East, Montreal, Quebec, H1T 1C8, Canada
    Circulation 109:412-8. 2004
    b>Congestive heart failure (CHF) downregulates atrial transient outward (I(to)), slow delayed rectifier (I(Ks)), and L-type Ca(2+) (I(Ca,L)) currents and upregulates Na(+)-Ca(2+) exchange current (I(NCX)) (ionic remodeling) and causes ..
  20. ncbi Retinopathy and risk of congestive heart failure
    Tien Y Wong
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    JAMA 293:63-9. 2005
    b>Congestive heart failure (CHF) affects a substantial proportion of adults including those without preexisting coronary heart disease...
  21. ncbi A perspective on the muscle reflex: implications for congestive heart failure
    Lawrence I Sinoway
    Division of Cardiology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Appl Physiol (1985) 99:5-22. 2005
    ..Data supporting the concept that the metaboreflex is attenuated and that the mechanoreflex is accentuated are presented. The role the muscle mechanoreflex plays in evoking renal vasoconstriction is also described...
  22. ncbi Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham Heart Study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Ann Intern Med 138:10-6. 2003
    Although hypertension is a principal precursor of congestive heart failure (CHF), the separate relations of systolic, diastolic, and pulse pressure with risk for heart failure have not been fully elucidated.
  23. pmc Effectiveness of transcendental meditation on functional capacity and quality of life of African Americans with congestive heart failure: a randomized control study
    Ravishankar Jayadevappa
    Department of Medicine, University of Pennsylvania, 224, Ralston Penn Center, 3615 Chestnut Street, Philadelphia, PA 19104 2676, USA
    Ethn Dis 17:72-7. 2007
    To evaluate the effectiveness of a Transcendental Meditation (TM) stress reduction program for African Americans with congestive heart failure (CHF).
  24. pmc Diastolic dysfunction and diastolic heart failure: diagnostic, prognostic and therapeutic aspects
    Maurizio Galderisi
    Division of Cardioangiology, CCU Department of Clinical and Experimental Medicine, Federico II University, Medical School Napoli, Italy
    Cardiovasc Ultrasound 3:9. 2005
    ..Several trials, completed or ongoing, have been planned to treat DD and diastolic HF...
  25. ncbi Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure
    Nessrine Hanna
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Cardiovasc Res 63:236-44. 2004
    b>Congestive heart failure (CHF) causes arrhythmogenic remodeling in both atria and ventricles, but differences between atrial and ventricular remodeling in CHF have not been well characterized.
  26. ncbi Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    J Card Fail 10:334-8. 2004
    ..pathophysiologic role of oxidative stress and the protective role of naturally occurring antioxidants in congestive heart failure (CHF)...
  27. ncbi Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial
    Franz Hartmann
    Medizinische Klinik II, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Circulation 110:1780-6. 2004
    ..the occurrence of death and hospitalization was prospectively evaluated in the COPERNICUS study, which enrolled patients with an ejection fraction <25% and symptoms of chronic congestive heart failure at rest or on minimal exertion.
  28. ncbi Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 105:1760-3. 2002
    ..Little is known, however, about the utility of these biomarkers in combination...
  29. ncbi Effect of a standardized nurse case-management telephone intervention on resource use in patients with chronic heart failure
    Barbara Riegel
    School of Nursing, San Diego State University, San Diego, CA 92182 4158, USA
    Arch Intern Med 162:705-12. 2002
    ..Case management is believed to promote continuity of care and decrease hospitalization rates, although few controlled trials have tested this approach...
  30. ncbi Autoantibodies against the myocardial beta1-adrenergic and M2-muscarinic receptors in patients with congestive heart failure
    Lin Zhang
    Institute of Cardiovascular Diseases, Heart Center, Beijing Chao Yang Hospital, Beijing 100020, China
    Chin Med J (Engl) 115:1127-31. 2002
    To determine whether autoantibodies against beta(1)-adrenergic and M(2)-muscarinic receptors are related to patients with congestive heart failure (CHF).
  31. pmc Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant
    Satsuki Yamada
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 577:1053-65. 2006
    ..2-KO. Within 48 h following aortic constriction, fulminant biventricular congestive heart failure, characterized by exercise intolerance, cardiac contractile dysfunction, hepatopulmonary congestion and ..
  32. ncbi Prolonged oxygen uptake kinetics during low-intensity exercise are related to poor prognosis in patients with mild-to-moderate congestive heart failure
    Christoph Schalcher
    Division of Cardiology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Chest 124:580-6. 2003
    To investigate the prognostic value of oxygen uptake (O(2)) kinetics during low-intensity exercise in patients with congestive heart failure.
  33. pmc Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure
    N Wisniacki
    Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK
    Heart 91:32-7. 2005
    ..To evaluate insulin resistance and systemic inflammation in older patients with systolic (SHF) or diastolic heart failure (DHF)...
  34. ncbi Circulating matrix metalloproteinase-2 is elevated in patients with congestive heart failure
    Taketoshi Yamazaki
    First Department of Internal Medicine, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, Fukui, 910 1193, Japan
    Eur J Heart Fail 6:41-5. 2004
    ..However, there are few reports describing the role of elevated level of circulating MMPs in congestive heart failure (CHF) patients...
  35. pmc Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)
    M F Piepoli
    Cardiac Medicine, Royal Brompton Hospital, Imperial College of Science Technology and Medicine, London
    BMJ 328:189. 2004
    ..To determine the effect of exercise training on survival in patients with heart failure due to left ventricular systolic dysfunction...
  36. ncbi Prevalence of depression in hospitalized patients with congestive heart failure
    Kenneth E Freedland
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63124, USA
    Psychosom Med 65:119-28. 2003
    Prevalence estimates of depression in hospitalized patients with congestive heart failure (CHF) differ considerably across studies...
  37. ncbi Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure
    Kersten M Small
    Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267 0564, USA
    N Engl J Med 347:1135-42. 2002
    ..We hypothesized that this combination of receptor variants, which results in increased synaptic norepinephrine release and enhanced receptor function at the myocyte, would predispose persons to heart failure...
  38. ncbi Atrial fibrillation and congestive heart failure: specific considerations at the intersection of two common and important cardiac disease sets
    Joachim R Ehrlich
    Division of Cardiology, J W Goethe University, Frankfurt, Germany
    J Cardiovasc Electrophysiol 13:399-405. 2002
    Atrial fibrillation (AF) and congestive heart failure (CHF) are two increasingly common cardiac disorders with a growing prevalence in the overall population...
  39. ncbi Cardiac resynchronization in chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington 40536 0284, USA
    N Engl J Med 346:1845-53. 2002
    ..We conducted a double-blind trial to evaluate this therapeutic approach...
  40. ncbi Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing
    Gerardo Ansalone
    Department of Heart Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 39:489-99. 2002
    ..The goal of this study was to compare the efficacy of biventricular pacing (BIV) at the most delayed wall of the left ventricle (LV) and at other LV walls...
  41. ncbi Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    Michael R Bristow
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 350:2140-50. 2004
    ....
  42. ncbi C-reactive protein as a predictor of improvement and readmission in heart failure
    J L Alonso-Martinez
    Department of Internal Medicine, Hospital de Navarra, Irunlarrea 3, 31008, Pamplona, Spain
    Eur J Heart Fail 4:331-6. 2002
    ....
  43. ncbi Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea
    L Katherine Morrison
    Division of Cardiology, Veteran s Affairs Medical Center, San Diego, California 92161, USA
    J Am Coll Cardiol 39:202-9. 2002
    ..Since B-type natriuretic peptide (BNP) is secreted by the left ventricle (LV) in response to volume elevated LV pressure, we sought to assess whether a rapid assay for BNP levels could differentiate cardiac from pulmonary causes of dyspnea...
  44. ncbi Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
    Alan S Maisel
    University of California, San Diego, Veterans Affairs Medical Center, San Diego 92161, USA
    N Engl J Med 347:161-7. 2002
    ..B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension...
  45. ncbi The effects of cognitive impairment on mortality among hospitalized patients with heart failure
    Giuseppe Zuccala
    Department of Gerontology, Catholic University of the Sacred Heart, Rome, Italy
    Am J Med 115:97-103. 2003
    ..Because cerebral metabolic abnormalities have been associated with reduced survival in younger patients with advanced heart failure, we assessed the effect of cognitive impairment on the survival of older patients with heart failure...
  46. ncbi Cognitive impairment: a key feature of congestive heart failure in the elderly
    Luigi Trojano
    Dept of Psychology, 2nd University of Naples, Caserta, Italy
    J Neurol 250:1456-63. 2003
    b>Congestive heart failure (CHF) has been proposed as a possible cause of cognitive dysfunction but only a few studies have directly assessed cognitive performance in CHF...
  47. ncbi Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
    ..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...
  48. ncbi Nocturnal oxygen therapy prevents progress of congestive heart failure with central sleep apnea
    Meiei Shigemitsu
    The Department of Internal Medicine, Yamanashi Red Cross Hospital, 6663 1 Funatsu, Fujikawaguchiko machi, Minamitsuru gun, Yamanashi, 401 0301 Japan
    Int J Cardiol 115:354-60. 2007
    Sleep disordered breathing has been reported to be associated with congestive heart failure (CHF). Nocturnal oxygen has been shown to abolish apnea...
  49. ncbi Effects of continuous positive airway pressure on pulmonary function and exercise tolerance in patients with congestive heart failure
    Veronica L Wittmer
    Physiological Sciences Graduate Program, Biomedical Center, Federal University of Espirito Santo, Av Marechal Campos 1468, Vitoria, 29042 755 ES, Brazil
    Chest 130:157-63. 2006
    ..has been used to improve cardiopulmonary function and reduce pulmonary edema symptoms in patients with congestive heart failure (CHF)...
  50. ncbi Prospective clinical evaluation of an ELISA B-type natriuretic peptide assay in the diagnosis of congestive heart failure in dogs presenting with cough or dyspnea
    Teresa C DeFrancesco
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Vet Intern Med 21:243-50. 2007
    B-type natriuretic peptide (BNP) is increased in dogs with congestive heart failure (CHF).
  51. ncbi Risks for atrial fibrillation and congestive heart failure in patients >/=65 years of age with abnormal left ventricular diastolic relaxation
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 93:54-8. 2004
    We sought to determine the risk for the first episodes of atrial fibrillation (AF) and congestive heart failure (CHF) in a cohort of patients aged >/=65 years who had abnormal left ventricular (LV) diastolic relaxation...
  52. ncbi Impact of race on health care utilization and outcomes in veterans with congestive heart failure
    Anita Deswal
    Houston Center for Quality of Care and Utilization Studies, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Cardiol 43:778-84. 2004
    ..were to determine racial differences in mortality in a national cohort of patients hospitalized with congestive heart failure (CHF) within a financially "equal-access" healthcare system, the Veterans Health Administration (VA), and ..
  53. ncbi On the rise: The current and projected future burden of congestive heart failure hospitalization in Canada
    Helen Johansen
    Health Statistics Division, Statistics Canada, Ottawa, Ontario, Canada
    Can J Cardiol 19:430-5. 2003
    The incidence of congestive heart failure (CHF) has increased due, in part, to an aging population and improvements in the diagnosis and treatment of myocardial infarction...
  54. pmc Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice
    Steven P Jones
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 100:4891-6. 2003
    b>Congestive heart failure results in cardiovascular dysfunction and diminished vascular nitric oxide (NO) production...
  55. ncbi Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
    K M Fox
    Cardiology Department, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Lancet 362:782-8. 2003
    ..We assessed whether the ACE inhibitor perindopril reduced cardiovascular risk in a low-risk population with stable coronary heart disease and no apparent heart failure...
  56. ncbi Time trends in the use of beta-blockers and other pharmacotherapies in older adults with congestive heart failure
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, Wash, USA
    Am Heart J 148:710-7. 2004
    Evidence supporting pharmacotherapy of congestive heart failure (CHF) has grown substantially over the past decade and includes large, placebo-controlled trials with mortality end points...
  57. ncbi Health outcomes in decompensated congestive heart failure: a comparison of tertiary hospitals in Brazil and United States
    Luis E Rohde
    Heart Failure and Cardiac Transplantation Units, Divisions of Cardiology at the Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul Medical School, Porto Alegre, Brazil
    Int J Cardiol 102:71-7. 2005
    Few international studies prospectively compared evidence-based practices and health outcomes among congestive heart failure (CHF) cohorts from countries with different cultural and economic backgrounds.
  58. pmc Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial
    Anique Ducharme
    Department of Medicine, Montreal Heart Institute, University of Montreal, Que
    CMAJ 173:40-5. 2005
    Although multidisciplinary congestive heart failure clinics in the United States appear to be effective in reducing the number of hospital readmissions, it is unclear whether the same benefit is seen in countries such as Canada, where ..
  59. ncbi Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity
    Maria Cristina Polidori
    Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    Free Radic Biol Med 32:148-52. 2002
    ..lycopene, and alpha- and beta-carotene were measured in 30 patients with class II and III congestive heart failure (CHF) according to the New York Heart Association (NYHA) classification and in 55 controls...
  60. ncbi Noninvasive assessment of cardiac pumping capacity during exercise predicts prognosis in patients with congestive heart failure
    Christoph Scharf
    Heart Failure and Cardiac Transplantation Unit, Division of Cardiology, University Hospital of Zurich, Zurich, Switzerland
    Chest 122:1333-9. 2002
    Prognostic parameters in patients with congestive heart failure (CHF) are important for guiding therapeutic options...
  61. ncbi Mechanical dyssynchrony assessed by tissue Doppler imaging is a powerful predictor of mortality in congestive heart failure with normal QRS duration
    Goo Yeong Cho
    Division of Cardiology, Hangang Sacred Heart Hospital, University of Hallym, Seoul, Korea
    J Am Coll Cardiol 46:2237-43. 2005
    We sought to test whether the mechanical dyssynchrony assessed by tissue Doppler imaging (TDI) is a predictor of cardiac events in patients with congestive heart failure (CHF) and QRS duration < or =120 ms.
  62. ncbi Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?
    Armin Zittermann
    Department of Nutrition Science, University of Bonn, Germany
    J Am Coll Cardiol 41:105-12. 2003
    This study was designed to evaluate the association between vitamin D status and congestive heart failure (CHF).
  63. ncbi Genetic susceptibility to atrial fibrillation in patients with congestive heart failure
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
    Heart Rhythm 3:808-12. 2006
    ..Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS)...
  64. ncbi Prognostic judgments and triage decisions for patients with acute congestive heart failure
    Wally R Smith
    Division of Quality Health Care, Department of Medicine, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298 0306, USA
    Chest 121:1610-7. 2002
    To determine how well triage physicians judge the probability of death or severe complications that require treatment only available in an ICU to maintain life for patients with acute congestive heart failure (CHF).
  65. ncbi The adequacy of laboratory monitoring in patients treated with spironolactone for congestive heart failure
    Keyur B Shah
    Department of Medicine, The University of Maryland School of Medicine and the Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
    J Am Coll Cardiol 46:845-9. 2005
    ..This study was designed to determine the adequacy of monitoring patients receiving spironolactone as well as spironolactone's relationship to hyperkalemia...
  66. pmc Heart failure and the aging population: an increasing burden in the 21st century?
    S Stewart
    CRI in Heart Failure, University of Glasgow, Glasgow, UK
    Heart 89:49-53. 2003
    ..Despite an overall decline in age adjusted mortality from coronary heart disease in developed countries, the number of patients with heart failure may be increasing...
  67. ncbi Effects of heat stress on thermoregulatory responses in congestive heart failure patients
    Jian Cui
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Circulation 112:2286-92. 2005
    ..with cardiovascular diseases, particularly those associated with impaired ventricular function and congestive heart failure (CHF)...
  68. ncbi Congestive heart failure in chronic kidney disease: disease-specific mechanisms of systolic and diastolic heart failure and management
    Bryan M Curtis
    Division of Nephrology and Clinical Epidemiology Unit Patient Research Centre, Health Sciences Centre, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland A1B 3V6, Canada
    Cardiol Clin 23:275-84. 2005
    ..Nonetheless, interventions such as controlling hypertension, specific pharmacologic options, lifestyle modification, anemia management, and early nephrology referral are recommended when appropriate...
  69. ncbi Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure
    Nicholas C Dang
    Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Heart Lung Transplant 25:1-6. 2006
    ..Few studies have examined outcomes for LVAD patients who subsequently develop RHF. This study details one center's experience with RHF in chronic congestive heart failure (CHF) patients.
  70. ncbi Association between congestive heart failure and hospitalization in patients with type 2 diabetes mellitus receiving treatment with insulin or pioglitazone: a retrospective data analysis
    Rukmini Rajagopalan
    Takeda Pharmaceuticals North America, Inc, Lincolnshire, Illinois 60069, USA
    Clin Ther 26:1400-10. 2004
    ..However, concerns have been raised regarding the association between TZD use and a heightened risk for congestive heart failure (CHF).
  71. ncbi Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with congestive heart failure and chronic kidney disease
    Alan K Berger
    Section of Cardiovascular Medicine, Department of Medicine, University of MN, Minneapolis, MN 55454, USA
    Am Heart J 153:1064-73. 2007
    ....
  72. ncbi Congestive heart failure is a rare event in patients receiving imatinib therapy
    Ehab Atallah
    Department of Leukemia, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:1233-7. 2007
    ..A total of 18 patients had previous medical conditions predisposing to cardiac failure: congestive heart failure (CHF; 6 [27%] patients), diabetes mellitus (6 [27%] patients), hypertension (10 [45%] patients), coronary ..
  73. ncbi Disease management programmes for older people with heart failure: crucial characteristics which improve post-discharge outcomes
    Doris S F Yu
    The Nethersole School of Nursing, The Chinese University of Hong Kong, Room 729, Esther Lee Building, Shatin, New Territories, Hong Kong
    Eur Heart J 27:596-612. 2006
    ..This may be explained by variations in the design of DMPs. The aim is to identify the characteristics of DMPs which are crucial to reducing hospital readmission and/or mortality of older people with heart failure...
  74. ncbi Trends in heart failure incidence and survival in a community-based population
    Veronique L Roger
    Division of Cardiovascular Diseases and Internal Medicine, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minn 55095, USA
    JAMA 292:344-50. 2004
    ..The epidemic of heart failure has yet to be fully investigated, and data on incidence, survival, and sex-specific temporal trends in community-based populations are limited...
  75. ncbi From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease
    Alan H Gradman
    Western Pennsylvania Hospital, Pittsburgh, PA 15224, USA
    Prog Cardiovasc Dis 48:326-41. 2006
    ..In patients with established LVH, regression is both possible and desirable and results in a significant reduction in adverse clinical endpoints...
  76. ncbi An angiotensin receptor blocker reduces the risk of congestive heart failure in elderly hypertensive patients with renal insufficiency
    Tsukasa Nakamura
    Shinmatsudo Central General Hospital, Matsudo, Japan
    Hypertens Res 28:415-23. 2005
    ..32/ 38). In particular, candesartan-based treatment reduced the incidence of congestive heart failure by 66.4% in these patients...
  77. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
    ..We evaluated its effects on morbidity and mortality...
  78. ncbi Regulation of cardiac remodeling by nitric oxide: focus on cardiac myocyte hypertrophy and apoptosis
    Kai C Wollert
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Heart Fail Rev 7:317-25. 2002
    ..In the future, these novel insights into the role of NO in cardiac remodeling should allow the development of novel therapeutic strategies to treat cardiac remodeling and failure...
  79. ncbi Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart
    Deborah M Dickey
    University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street Southeast, Minneapolis, Minnesota 55455, USA
    Endocrinology 148:3518-22. 2007
    ..Physiological responses to ANP and BNP are diminished in congestive heart failure (CHF) by an unknown mechanism...
  80. ncbi Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study
    John S Gottdiener
    St Francis Hospital, Roslyn, New York Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 137:631-9. 2002
    Most persons with congestive heart failure are elderly, and many elderly persons with congestive heart failure have normal left ventricular systolic function.
  81. ncbi Prognostic value of heart rate variability in chronic congestive heart failure (Veterans Affairs' Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure)
    Kenneth C Bilchick
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 90:24-8. 2002
    ..data from 179 patients in the Veterans Affairs' Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure to determine if HRV (expressed as the SD of the normal-to-normal RR intervals [SDNN]) would be useful as ..
  82. ncbi Diurnal blood pressure pattern and risk of congestive heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    JAMA 295:2859-66. 2006
    High blood pressure is the most important risk factor for congestive heart failure (CHF) at a population level, but the relationship of an altered diurnal blood pressure pattern to risk of subsequent CHF is unknown.
  83. ncbi Sleep-disordered breathing occurs frequently in stable outpatients with congestive heart failure
    Katherine Ferrier
    WellSleep, Department of Medicine, Wellington School of Medicine and Health Sciences, New Zealand
    Chest 128:2116-22. 2005
    Sleep-disordered breathing (SDB) has a potential role in the pathogenesis of congestive heart failure (CHF)...
  84. ncbi Congestive heart failure in Latin America: the next epidemic
    Luz A Cubillos-Garzón
    Heart Failure Council, Colombian Society of Cardiology, Bogota, Colombia
    Am Heart J 147:412-7. 2004
    Coronary artery disease is the main cause of congestive heart failure (CHF) in all populations...
  85. ncbi Gender, age, and heart failure with preserved left ventricular systolic function
    Frederick A Masoudi
    Denver Health Medical Center, Division of Cardiology, Colorado 80204, USA
    J Am Coll Cardiol 41:217-23. 2003
    ..This study was designed to determine if women are more likely than men to have heart failure (HF) with preserved systolic function after adjustment for potential confounders, including age...
  86. ncbi Congestive heart failure in copper-deficient mice
    Laila Elsherif
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40202, USA
    Exp Biol Med (Maywood) 228:811-7. 2003
    ..This study shows that CuD leads to systolic and diastolic dysfunction in association with histopathological changes, which are indices commonly used to diagnose congestive heart failure.
  87. ncbi Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized study
    Amit N Patel
    Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    J Thorac Cardiovasc Surg 130:1631-8. 2005
    ..A randomized study was conducted with a novel epicardial technique to deploy stem cells as an adjuvant to conventional revascularization therapy in patients with congestive heart failure.
  88. ncbi Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans
    Prashanthan Sanders
    Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia
    Circulation 108:1461-8. 2003
    Atrial fibrillation (AF) frequently complicates congestive heart failure (CHF). However, the electrophysiological substrate for AF in humans with CHF remains unknown...
  89. ncbi Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition
    Andreas Schafer
    Medizinische Universitatsklinik, Wurzburg, Germany
    Thromb Haemost 89:1024-30. 2003
    An increased risk of thrombembolic events in congestive heart failure (CHF) has been attributed to a hypercoagulable state including vascular endothelial dysfunction and platelet activation...
  90. ncbi Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study
    Saif Anwaruddin
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:91-7. 2006
    ..Even in the presence of renal insufficiency, NT-proBNP remained a valuable tool for the diagnosis of acute congestive heart failure and it provides important prognostic information.
  91. ncbi Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Site 2, Framingham, MA 01702 5803, USA
    JAMA 289:1251-7. 2003
    Elevated plasma homocysteine levels are associated with increased risk of vascular disease. It is unclear whether elevated homocysteine levels are a risk factor for congestive heart failure (CHF).
  92. ncbi Does hospitalization for congestive heart failure occur more frequently in Ramadan: a population-based study (1991-2001)
    J Al Suwaidi
    Department of Cardiology and Cardiovascular Surgery, Hamad Medical Corporation and Hamad General Hospital, P O Box 3050 Doha, State of Qatar
    Int J Cardiol 96:217-21. 2004
    ..radical change in lifestyle for the period of one lunar month, so it is important to see the response of congestive heart failure patients to this change...
  93. ncbi Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure
    Andreas Daiber
    Klinikum der Johannes Gutenberg Universitat, II Medizinische Klinik und Poliklinik, Labor für Molekulare Kardiologie, 55101 Mainz, Germany
    Biochem Biophys Res Commun 338:1865-74. 2005
    ..ISDN) will favorably influence the nitroso-redox balance in the cardiovascular system in patients with congestive heart failure and may explain at least in part the improvement of prognosis in patients with chronic congestive heart ..
  94. ncbi An economic analysis of specialist heart failure nurse management in the UK; can we afford not to implement it?
    S Stewart
    Department of Cardiology, The Queen Elizabeth Hospital University of Adelaide, Australia
    Eur Heart J 23:1369-78. 2002
    ..This study evaluated the economic impact of applying specialist nurse management programmes that limit heart failure-related hospital readmissions within a whole population...
  95. ncbi Exercise-induced pulmonary edema in heart failure
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
    Circulation 108:2666-71. 2003
    ..If pulmonary edema developed, alveolar-capillary membrane conductance (Dm), measured immediately after exercise, would decrease. To test this hypothesis, we measured Dm before and at 2 and 60 minutes after exercise...
  96. ncbi Are beta-blockers as efficacious in patients with diabetes mellitus as in patients without diabetes mellitus who have chronic heart failure? A meta-analysis of large-scale clinical trials
    Steven Joseph Haas
    NHMRC Centre of Clinical Research Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Am Heart J 146:848-53. 2003
    ....
  97. ncbi Home-based intervention in congestive heart failure: long-term implications on readmission and survival
    Simon Stewart
    Division of Health Sciences, University of South Australia
    Circulation 105:2861-6. 2002
    ..to what extent initially observed benefits of postdischarge programs of care for patients with chronic congestive heart failure (CHF) in respect to event-free survival, readmissions, and healthcare costs persist in the long term...
  98. ncbi Cost-effectiveness of primary implanted cardioverter defibrillator for sudden death prevention in congestive heart failure
    Lei Chen
    Department of Pharmaceutical Economics and Policy, University of Southern California, Los Angeles, CA 90089, USA
    Cardiovasc Drugs Ther 18:161-70. 2004
    Implanted cardioverter defibrillator (ICD) is expensive but highly effective in preventing sudden death. The value of primary prophylactic ICD in preventing sudden death for congestive heart failure patients (CHF) has not been established.
  99. ncbi Congestive heart failure: what should be the initial therapy and why?
    Kanu Chatterjee
    Chatterjee Center for Cardiac Research, Moffitt Long Hospital, University of California, San Francisco, California 94143 0124, USA
    Am J Cardiovasc Drugs 2:1-6. 2002
    ....
  100. ncbi QRS duration and mortality in patients with congestive heart failure
    Stephen Iuliano
    Veterans Affairs and Georgetown University Medical Centers, Washington, DC 20422, USA
    Am Heart J 143:1085-91. 2002
    ..The purpose of this study was to examine the association between QRS duration and survival in patients with heart failure...
  101. pmc National survey of the prevalence, incidence, primary care burden, and treatment of heart failure in Scotland
    N F Murphy
    Department of Cardiology, Western Infirmary, Glasgow, UK
    Heart 90:1129-36. 2004
    ..To examine the epidemiology, primary care burden, and treatment of heart failure in Scotland, UK...

Research Grants77

  1. Labeled inhibitors for angiotensin converting enzyme
    John Babich; Fiscal Year: 2004
    ..the trend of decreasing death rates attributable to ischemic heart disease and stroke, the prevalence of congestive heart failure and the resultant death rates in the United States have almost tripled over the past three decades...
  2. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..transporter is a potential drug target for treating a variety of conditions ranging from hypertension, congestive heart failure, to syndrome of inappropriate secretion of antidiuretic hormone compounds (SIADH)...
  3. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..It increases a person's risk for kidney disease, stroke, coronary artery disease, congestive heart failure and overall mortality...
  4. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..The Na,K-ATPase is the pharmacological target for cardiac glycosides, a widely used therapy for congestive heart failure. Considering the mounting evidence that cellular distribution of Na,K-ATPase plays a key role in its ..
  5. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the proliferation of therapies, congestive heart failure (HF) remains a progressive disease...
  6. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..the respiratory chemoreflexes during sleep could have clinical use, as 1) In certain conditions like congestive heart failure, chemoreflex sensitivity is reliably increased, correlates with disease severity and outcomes, and ..
  7. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..Narrative Blood pressure abnormalities are major risk factors for coronary artery disease, stroke, congestive heart failure and syncope...
  8. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..e. coronary heart disease, stroke and congestive heart failure) compared to individuals with an apnea/hypopnea index of less than 1 event per hour...
  9. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..Dysfunction of VP release contributes to human pathophysiology, such as congestive heart failure, and the results may suggest novel treatment strategies and/or new insights into genomic underpinnings of ..
  10. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..including: hypertension, stroke, coronary artery disease, cardiomyopathies, myocardial infarction, congestive heart failure, and sudden cardiac death...
  11. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..CKD afflicts more individuals over 65 years old than diabetes or congestive heart failure, approximately 40% of older patients...
  12. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..This Pilot study may also provide insights into other chronic illness characterized by fatigue and other musculoskeletal symptoms, such as peripheral vascular disease and congestive heart failure.
  13. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ..Obesity and other health disparities Complicating Filipino Women's Health and Reproduction Update on Congestive Heart Failure The Spectrum of Ischemic Heart Disease Preeclampsia in disadvantaged population - Diagnosis and ..
  14. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..as chronic hypertension and ischemic heart disease result in cardiac hypertrophy and the development of congestive heart failure. Heart failure is associated with high mortality and morbidity and poor quality of life...
  15. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
    ..cultured cardiac myocytes by stretch and Angiotensin II (AII), a hormone implicated in hypertension and congestive heart failure. Destabilization is induced by Nadph oxidase (Nox)-generated superoxide and activation of ASK1 and p38 ..
  16. Mediators &prognostic value of muscle mass &function in chronic kidney disease
    Francis Perry Wilson; Fiscal Year: 2013
    ..powerful predictors of mortality in aging and a variety of chronic conditions including AIDS, cancer and congestive heart failure. Cross-sectional studies suggest correlations between low muscle mass and eGFR in patients with CKD, but ..
  17. GILZ Regulation of ENaC
    David Pearce; Fiscal Year: 2012
    ..of this hormone are a major cause of hypertension, and are implicated in fluid overload states such as congestive heart failure. This proposal examines the molecules involved in mediating aldosterone signaling, and how it causes salt ..
  18. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  19. Clinical Impact of Human Coronaviruses and Viral Diversity
    Geoffrey J Gorse; Fiscal Year: 2012
    ..with a range of respiratory illnesses that affect the status of underlying chronic lung diseases and congestive heart failure. In 1998-99, prototype HCoV strains (229E and OC43) were associated with about 1/7th of acute respiratory ..
  20. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..chronic alcohol abusers display cardiac dysfunction, leading to dilated cardiomyopathy and eventually to congestive heart failure. Functionally, alcoholic cardiomyopathy (ACM) is characterized by reversible and irreversible alterations...
  21. Phospholemman and Cardiac Contracility
    Joseph Y Cheung; Fiscal Year: 2013
    ..2 classes of drugs (b-blockers and ACE inhibitors) that have been clinically found to be efficacious in congestive heart failure and ischemic heart disease may have PLM as a common target...
  22. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..cause of death in the United States and is associated with a variety of clinical abnormalities, including congestive heart failure, ventricular remodeling, ischemia, ion homeostasis, arrhythmias, and sudden cardiac death...
  23. Silencing cardiac-specific microRNAs to prevent pathological remodeling in conges
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2011
    ..to define microRNA changes associated with cardiac remodeling and dysfunction in the setting of congestive heart failure (CHF)...
  24. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    ..AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  25. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..abberant CSF pulsations observed in other clinical diseases including stroke, closed head injury, and congestive heart failure which may be at risk for further neurological damage related to decreased CBF and abnormal CSF ..
  26. Role of Protein Acetylation in Ncx1 Expression
    Donald R Menick; Fiscal Year: 2012
    b>Congestive heart failure is a complex disorder in which the heart is unable to pump a sufficient quantity of blood to meet the metabolic needs of the individual...
  27. Purinergic signaling in sleep apnea
    Elzbieta Kaczmarek; Fiscal Year: 2012
    ..of cardiovascular diseases, including systemic and pulmonary hypertension, coronary artery disease, congestive heart failure, stroke, cardiac arrhythmias, and sudden cardiac death...
  28. STATINS AND ACE INHIBITORS IN ADULTS WITH DIABETES AND COMORBID CONDITIONS
    David E Grembowski; Fiscal Year: 2010
    ..Co-morbid conditions are hypertension, coronary artery disease, congestive heart failure, and depression. Study Design. Population-based, retrospective longitudinal cohort. Data Sources...
  29. Genome-wide Association Study: Fetal Hemoglobin Phenotypes in Sickle Cell Disease
    Betty Pace; Fiscal Year: 2009
    ..including those with peripheral artery disease, intermittent claudication, coronary artery disease, congestive heart failure, asthma, COPD, and the elderly (>75y)...
  30. Analysis of distal conboluted tubule function in vivo
    James A McCormick; Fiscal Year: 2012
    ..in the United States and is an important risk factor for death from stroke, myocardial infarction, congestive heart failure, and chronic kidney disease...
  31. The role of the Wnt/planar cell polarity pathway in pulmonary angiogenesis
    Vinicio A de Jesus Perez; Fiscal Year: 2013
    ..progressive disorder associated with abnormally elevated pulmonary pressures that, if untreated, lead to congestive heart failure and premature death...
  32. Cell Death in Alcoholic Heart and Muscle
    Emanuel Rubin; Fiscal Year: 2013
    ..In fact, the most common cause of cardiomyopathy with congestive heart failure is chronic alcoholism. However, the pathogenesis of these conditions still remains obscure...
  33. Stem Cells For Myocardial Repair: A Large Bore Magnet Study
    Jianyi Zhang; Fiscal Year: 2012
    ..After a period stable hypertrophy myocardial dysfunction can develop and may ultimately lead to overt congestive heart failure (CHF) that is a most significant clinical problem...
  34. Development of an In Vivo Stem Cell Tracking Method Using Ultrasound Imaging
    Flordeliza S Villanueva; Fiscal Year: 2010
    ..b>Congestive heart failure resulting from myocardial infarction and subsequent adverse left ventricular remodeling is a major cause ..
  35. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..Chronic congestive heart failure is the largest unsolved problem in cardiac care today. There are over 5...
  36. Genetics of risk of chemotherapy-induced cardiotoxicity in cancer survivors
    Peter Demant; Fiscal Year: 2013
    ..However, in 50% of survivors they cause subclinical heart injury that can progress into incurable congestive heart failure. As ACT contributes significantly to morbidity and mortality of cancer survivors, prediction of ACT risk ..
  37. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    ..While an estimated 40,000 congestive heart failure patients are candidates for heart transplantation, only 2,200 donor hearts are made available each year ..
  38. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    In the US, congestive heart failure (HF) is a common and lethal disease with 500,000 patients being diagnosed, and with ~300,000 deaths each year. Sympathoexcitation plays a prominent role in disease progression...
  39. Characterization of a Novel Erythropoietin Signaling Pathway
    Adam N Goldfarb; Fiscal Year: 2013
    ..The most prominent adverse side-effects of Epo consist of cardiovascular complications, particularly congestive heart failure (CHF)...
  40. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..changes involving KATP channels during the response to cardiac stress contribute to the development of congestive heart failure (CHF)...
  41. Histamine Receptor Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2013
    ..selective H3-receptor agonists) mimicking the beneficial effects of preconditioning and enabling a safe and effective treatment of congestive heart failure with natriuretic peptides. and ATP sensory/sympathetic nerves will be assessed
  42. Regulation of Aldosterone Production in the Adrenal
    Wendy B Bollag; Fiscal Year: 2013
    ..the adrenal gland result in and/or exacerbate several human diseases including high blood pressure and congestive heart failure. These disorders are prevalent in the veteran population, with nearly 3...
  43. Aldosterone and Sodium Regulation in Postural Tachycardia Syndrome
    Satish R Raj; Fiscal Year: 2013
    ..POTS have significantly diminished health-related quality of life, to levels comparable to patients with congestive heart failure or chronic obstructive pulmonary disease...
  44. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..is well recognized as a major risk factor for a broad range of cardiovascular diseases such as stroke, congestive heart failure, renal disease, and congestive heart failure...
  45. Attenuation of cardiac parasympathetic nerve acetylcholine release in obesity by
    Wohaib Hasan; Fiscal Year: 2012
    ..Abnormal autonomic drive is a causal factor in hypertension and congestive heart failure, and may similarly promote cardiovascular disturbances in obesity...
  46. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..When post-operative causes are excluded, pneumonia, chronic obstructive pulmonary disease (COPD), and congestive heart failure comprise the top three reasons for initiating mechanical ventilation...
  47. Mitochondrial Matrix Metalloproteinase-2 and Cardiac Injury
    David H Lovett; Fiscal Year: 2013
    ..of a specific MMP, (MMP-2), in models of cardiac injury and in the settings of myocardial infarction or congestive heart failure. Clinically, MMP-2 directly contributes to progressive ventricular remodeling and congestive heart ..
  48. Insulin Sensitivity using Aerobic Interval Conditioning (ISAIC)
    Conrad P Earnest; Fiscal Year: 2010
    ..including those with peripheral artery disease, intermittent claudication, coronary artery disease, congestive heart failure, asthma, COPD, and the elderly (>75y)...
  49. Catalase therapy for cardiac regeneration
    Michael E Davis; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Congestive heart failure is a leading cause of morbidity and mortality worldwide and effective treatment options are greatly ..
  50. Intermittent hypoxia, adiponectin, and insulin resistance in cardiovascular risk
    NARASIMHAM LAXMI PARINANDI; Fiscal Year: 2013
    ..OSA is very common in congestive heart failure (CHF) occurring in up to a third of patients...
  51. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    In the US, congestive heart failure (HF) is a common and lethal disease with 500,000 patients being diagnosed, and with ~300,000 deaths each year. Sympathoexcitation plays a prominent role in disease progression...
  52. Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
    William F Weitzel; Fiscal Year: 2013
    ..managing the fluid status for a number of disease states, including chronic kidney disease (CKD), congestive heart failure (CHF), liver failure, and lymphedema...
  53. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
    ..g., congestive heart failure, ischemic vascular disease)...
  54. Statins protect against adverse cardiac events during pneumonia
    Carlos J Orihuela; Fiscal Year: 2012
    ..of individuals >65 years of age experience some form of adverse cardiac event including arrhythmias, congestive heart failure, or myocardial infarction...
  55. Enhanced Risk Adjustment Using Laboratory Test and Pharmacy Data
    Amresh Hanchate; Fiscal Year: 2013
    ..of all VA admissions (16 percent) and inpatient deaths (30 percent) - acute myocardial infarction, congestive heart failure, cirrhosis and alcoholic hepatitis, chronic obstructive pulmonary disease, gastrointestinal hemorrhage, ..
  56. Determinants and Cardiovascular Consequences of Diabetes in Older Adults
    Susan J Zieman; Fiscal Year: 2012
    ..portion of the US population, and it dramatically increases the risks of cardiovascular disease (CVD) and congestive heart failure (CHF) in this age group...
  57. Interleukin-18 and post infarct myocardial remodeling
    Bysani Chandrasekar; Fiscal Year: 2013
    ..Post-infarct myocardial remodeling, hypertrophy and its transition to congestive heart failure are important diseases, resulting in quarter million deaths and one million hospitalizations annually in ..
  58. Role of natriuretic peptides in the ductus arteriosus
    JOHN JEFFREY REESE; Fiscal Year: 2013
    ..and may prolong patency of the postnatal DA, and 2) elevated postnatal NP levels due to PDA and secondary congestive heart failure help to maintain the DA in a non-contractile state...
  59. Cardiac Regenerative Therapy with Cyclin A2
    Hina W Chaudhry; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Congestive heart failure is the leading cause of hospitalization in the U.S...
  60. Sudden Cardiac Death in Heart Failure Trial 10 year Follow-up (SCD-HeFT 10 yr.)
    Gust H Bardy; Fiscal Year: 2010
    ..policy for ICD therapy and remains the reference point for all other ICD evaluations in patients with congestive heart failure from ischemic or non-ischemic systolic dysfunction...
  61. Coordinated Telehealth Care Program for Rural Elders with Congestive Heart Failur
    Hongtu Chen; Fiscal Year: 2010
    ..telehealth/remote patient monitoring and care coordination for rural, older patients with a diagnosis of congestive heart failure (CHF)...
  62. Gap Junction Trafficking to and within the Plasma Membrane
    ROBIN MARK SHAW; Fiscal Year: 2013
    ..by applicant): Ischemic heart disease and its associated complications of sudden cardiac death and congestive heart failure remain leading causes of morbidity and mortality in the United States...
  63. Vasomotor Sympathetic Activity during Early Pregnancy in Humans
    Qi Fu; Fiscal Year: 2010
    ..Caucasian women that during early pregnancy, sympathetic activity was extremely high (similar to those of congestive heart failure patients), while paradoxically their blood pressure and peripheral vascular resistance were normal...
  64. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Project Summary/Abstract Myocardial infarction and resulting congestive heart failure remain the number one cause of mortality in the United States and affect the aging veteran population particularly...
  65. Stimulation Induced Modulation of Sleep
    MATTHEW TARLER; Fiscal Year: 2009
    ..In congestive heart failure, augmented carotid chemoreflexes contributes to the increased sympathetic drive so typical of the disease...
  66. Shared Decision-Making in End-Stage Heart & Lung Disease
    Mark Sullivan; Fiscal Year: 2005
    b>Congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are among the most common causes of death in U.S. adults, yet they have received relatively little attention in the hospice or palliative care literature...
  67. DEVELOPING CELLULAR CARDIOMYOPLASTY FOR INJURED HEART
    DORIS TAYLOR; Fiscal Year: 2001
    ..end result of ischemic heart disease (IHD) is often progression of acute myocardial infarction (AMI) to congestive heart failure (CHF) resulting in the death of over 41,000 persons annually...
  68. PROVIDING TELE HOME CARE TO CHRONICALLY ILL RURAL OLDER
    Pamela Whitten; Fiscal Year: 2000
    ..and organizational delivery impacts of monitoring chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) patients who are attempting to manage their condition without prescribed home health services...
  69. OXIDATIVE PHOSPHORYLATION IN CARDIAC HYPERTROPHY
    TERRENCE O BRIEN; Fiscal Year: 2000
    ..understand the mechanisms of cardiac hypertrophic stimulation and its subsequent progression to congestive heart failure, sense must be made of a complex cascade of hemodynamic and molecular events that affect the cardiocyte's ..
  70. Xanthine oxidase inhibitor for congestive heart failure
    Alex Nivorozhkin; Fiscal Year: 2002
    b>Congestive heart failure (CHF) is a major market opportunity for therapeutics that targets the fundamental etiology of the ventricular injury...
  71. Nox Isoforms and Vascular Cell Phenotype
    John Keaney; Fiscal Year: 2009
    Clinical manifestations of cardiovascular disease, such as heart attack, stroke, and congestive heart failure, are the number one cause of death in the developed world...
  72. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
    ..early disease states usually go unrecognized clinically, since patients seldom experience any symptom of congestive heart failure When the extent of cardiac dysfunction becomes clinically evident, the disease has invariably resulted in ..
  73. Bone Marrow Angioblasts for Myocardial Vasculogenesis
    Silviu Itescu; Fiscal Year: 2006
    b>Congestive heart failure remains a major public health problem, and is frequently the result of left ventricular remodeling after myocardial infarction...
  74. Advanced Source Reconstruction Techniques for Fetal Magnetocardiography
    Mihai Popescu; Fiscal Year: 2009
    ..heart anomalies is critical for monitoring or prompt interventions, which can reduce the risks of congestive heart failure. This calls for sustained efforts to improve the existing tools and methodologies used for the non-..
  75. MYOSIN CROSSBRIDGE FUNCTION IN HUMAN HEART FAILURE
    Norman Alpert; Fiscal Year: 1999
    In congestive heart failure due to mitral regurgitation (MR) and idiopathic dilated cardiomyopathy (IDCM) the dilated ventricle undergoes dramatic decreases in the velocity of myocardial shortening and power output...
  76. BASIS FOR RENAL RESISTANCE TO ATRIAL NATRIURETIC PEPTIDE
    Michael Humphreys; Fiscal Year: 2004
    DESCRIPTION: States of pathological sodium retention and edema formation such as congestive heart failure, nephrotic syndrome, and cirrhosis of the liver are characterized by renal resistance to the natriuretic action of atrial ..
  77. MYOCARDIAL PROTEIN KINASE C & B-ADRENOCEPTORS IN CHF
    Chang Seng Liang; Fiscal Year: 1990
    ..whether activation of protein kinase C is responsible for cardiac beta-adrenergic desensitization in congestive heart failure, we propose 1) to compare the number and/or activity of cardiac sarcolemmal protein kinase C in heart ..