myocarditis

Summary

Summary: Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.

Top Publications

  1. ncbi Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches
    Hassan Abdel-Aty
    Franz Volhard Klinik, Charite Campus Buch, Universität Medizin Berlin, Berlin, Germany
    J Am Coll Cardiol 45:1815-22. 2005
  2. pmc Cardiovascular magnetic resonance in myocarditis: A JACC White Paper
    Matthias G Friedrich
    Department of Cardiac Sciences and Radiology, Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Canada
    J Am Coll Cardiol 53:1475-87. 2009
  3. pmc IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
    Ester Roffe
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:649-60. 2012
  4. pmc Atlantic salmon reovirus infection causes a CD8 T cell myocarditis in Atlantic salmon (Salmo salar L.)
    Aase B Mikalsen
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    PLoS ONE 7:e37269. 2012
  5. pmc Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
    Daniela Cihakova
    Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 172:1195-208. 2008
  6. ncbi Update on myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Strasse 1, Homburg Saar, Germany
    J Am Coll Cardiol 59:779-92. 2012
  7. ncbi Long-term follow-up of biopsy-proven viral myocarditis: predictors of mortality and incomplete recovery
    Stefan Grün
    Department of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, Stuttgart, Germany
    J Am Coll Cardiol 59:1604-15. 2012
  8. ncbi Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis
    Makiko Ohshima
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Osaka, Japan
    J Mol Cell Cardiol 53:420-8. 2012
  9. pmc Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
    Masashi Morita
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Mol Cell Biol 24:6719-27. 2004
  10. ncbi Presentation, patterns of myocardial damage, and clinical course of viral myocarditis
    Heiko Mahrholdt
    Division of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, 70376 Stuttgart, Germany
    Circulation 114:1581-90. 2006

Detail Information

Publications350 found, 100 shown here

  1. ncbi Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches
    Hassan Abdel-Aty
    Franz Volhard Klinik, Charite Campus Buch, Universität Medizin Berlin, Berlin, Germany
    J Am Coll Cardiol 45:1815-22. 2005
    The aim of this research was to identify the diagnostic performance of gadolinium-enhanced and T2-weighted cardiovascular magnetic resonance (CMR) in suspected acute myocarditis.
  2. pmc Cardiovascular magnetic resonance in myocarditis: A JACC White Paper
    Matthias G Friedrich
    Department of Cardiac Sciences and Radiology, Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Canada
    J Am Coll Cardiol 53:1475-87. 2009
    ..has become the primary tool for noninvasive assessment of myocardial inflammation in patients with suspected myocarditis. The International Consensus Group on CMR Diagnosis of Myocarditis was founded in 2006 to achieve consensus ..
  3. pmc IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
    Ester Roffe
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:649-60. 2012
    ..pathologic, immunologic, and molecular parameters in two mouse models with opposite susceptibility to acute myocarditis caused by the myotropic Colombiana strain of T...
  4. pmc Atlantic salmon reovirus infection causes a CD8 T cell myocarditis in Atlantic salmon (Salmo salar L.)
    Aase B Mikalsen
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    PLoS ONE 7:e37269. 2012
    ..is a disease characterized by a chronic myocarditis involving the epicardium and the compact and spongious part of the heart ventricle...
  5. pmc Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
    Daniela Cihakova
    Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 172:1195-208. 2008
    We report here that interleukin (IL)-13 protects BALB/c mice from myocarditis, whether induced by peptide immunization or by viral infection...
  6. ncbi Update on myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Strasse 1, Homburg Saar, Germany
    J Am Coll Cardiol 59:779-92. 2012
    b>Myocarditis is an inflammatory disease of the heart frequently resulting from viral infections and/or post-viral immune-mediated responses. It is one of the important causes of dilated cardiomyopathy worldwide...
  7. ncbi Long-term follow-up of biopsy-proven viral myocarditis: predictors of mortality and incomplete recovery
    Stefan Grün
    Department of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, Stuttgart, Germany
    J Am Coll Cardiol 59:1604-15. 2012
    This study sought to evaluate the long-term mortality in patients with viral myocarditis, and to establish the prognostic value of various clinical, functional, and cardiovascular magnetic resonance (CMR) parameters.
  8. ncbi Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis
    Makiko Ohshima
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Osaka, Japan
    J Mol Cell Cardiol 53:420-8. 2012
    ..mesenchymal stem cells (MSCs) similarly attenuated myocardial injury in rats with experimental autoimmune myocarditis (EAM)...
  9. pmc Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
    Masashi Morita
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Mol Cell Biol 24:6719-27. 2004
    ..Unexpectedly, Trex1(-/-) mice exhibit a dramatically reduced survival and develop inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure.
  10. ncbi Presentation, patterns of myocardial damage, and clinical course of viral myocarditis
    Heiko Mahrholdt
    Division of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, 70376 Stuttgart, Germany
    Circulation 114:1581-90. 2006
    Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) and human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples.
  11. ncbi V gamma 1+ T cells suppress and V gamma 4+ T cells promote susceptibility to coxsackievirus B3-induced myocarditis in mice
    S A Huber
    Department of Pathology, University of Vermont, Burlington, VT 05446, USA
    J Immunol 165:4174-81. 2000
    ..mice, which express the MHC class II IA but not IE Ag, results in virus replication in the heart but minimal myocarditis. In contrast, Bl.Tg...
  12. ncbi MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis
    Maarten F Corsten
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Circ Res 111:415-25. 2012
    Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in previously healthy people...
  13. ncbi Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
    Alida L P Caforio
    Division of Cardiology, Department of Cardiological Thoracic and Vascular Sciences, University of Padua, Padova, Italy
    Eur Heart J 34:2636-48, 2648a-2648d. 2013
    ..an expert consensus group reviews the current knowledge on clinical presentation, diagnosis and treatment of myocarditis, and proposes new diagnostic criteria for clinically suspected myocarditis and its distinct biopsy-proven ..
  14. pmc A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-κB signaling
    Jun Gui
    Institute for Immunobiology, Shanghai Medical College, Fudan University, Shanghai, People s Republic of China
    PLoS ONE 7:e46515. 2012
    Viral myocarditis, which is most prevalently caused by Coxsackievirus B3 (CVB3) infection, is a serious clinical condition characterized by cardiac inflammation...
  15. ncbi MicroRNA- 1 represses Cx43 expression in viral myocarditis
    Hong fei Xu
    Department of Forensic Medicine, Shanghai Medical College, Fudan University, Xuhui District, Shanghai, People s Republic of China
    Mol Cell Biochem 362:141-8. 2012
    ..In this study, we investigated miR-1 expression and its potential role in the mouse model of viral myocarditis (VMC)...
  16. pmc Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis
    Hai Yan Pan
    Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
    Cardiovasc Res 89:595-603. 2011
    ..We investigated the pathological roles of trypsin up-regulation in the progression of IAV-induced myocarditis, cytokine induction, and viral replication in the hearts, and also investigated the protective effects of ..
  17. ncbi Myopericarditis: Etiology, management, and prognosis
    Massimo Imazio
    Cardiology Department, Maria Vittoria Hospital, Via Cibrario 72, 10141 Torino, Italy
    Int J Cardiol 127:17-26. 2008
    Acute pericarditis is often accompanied by some degree of myocarditis. In clinical practice both pericarditis and myocarditis coexist because they share common etiologic agents, mainly cardiotropic viruses...
  18. ncbi Suspected chronic myocarditis at cardiac MR: diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence
    Matthias Gutberlet
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Charite, Campus Virchow Klinikum, Berlin, Germany
    Radiology 246:401-9. 2008
    ..cardiac magnetic resonance (MR) imaging approaches for the detection of histologic and immunohistologic criteria (reference standard) proved myocardial inflammation in patients clinically suspected of having chronic myocarditis (CMC).
  19. ncbi Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy
    G Christian Baldeviano
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 106:1646-55. 2010
    One-third of myocarditis cases progresses to dilated cardiomyopathy (DCM), but the mechanisms controlling this process are largely unknown...
  20. ncbi Predictors of outcome in patients with suspected myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Circulation 118:639-48. 2008
    The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy.
  21. ncbi Molecular biology and pathogenesis of viral myocarditis
    Mitra Esfandiarei
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Providence Health Care Research Institute, Vancouver, Canada
    Annu Rev Pathol 3:127-55. 2008
    b>Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. Several viruses have been associated with myocarditis in humans. However, coxsackievirus B3 is still considered the dominant etiological agent...
  22. ncbi Fatal coxsackievirus A16 infection
    Chung Yi Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatr Infect Dis J 23:275-6. 2004
    A 15-month-old boy presenting with hand, foot and mouth disease died of myocarditis and intractable shock caused by coxsackievirus A16 infection. It is apparent that coxsackievirus A16 infection is not always a benign infection.
  23. ncbi Histologic and in situ viral findings in the myocardium in cases of sudden, unexpected death
    Adina M Cioc
    Department of Pathology, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Mod Pathol 15:914-22. 2002
    ..In summary, in situ viral detection was documented in each case of idiopathic myocarditis associated with sudden, unexpected death; in 6/13 cases, the myocarditis was focal and minimal...
  24. ncbi Quantitative analysis of cardiac lesions in chronic canine chagasic cardiomyopathy
    Marcelo Vidigal Caliari
    Departamento de Patologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brasil
    Rev Inst Med Trop Sao Paulo 44:273-8. 2002
    ..All of the infected dogs showed chronic myocarditis with variable reduction levels of cardiac muscle, fibrosis and adipose tissue replacement...
  25. ncbi Extracorporeal membranous oxygenation support for acute fulminant myocarditis: analysis of a single center's experience
    Kang Hong Hsu
    Department of Cardiovascular Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Eur J Cardiothorac Surg 40:682-8. 2011
    Acute fulminant myocarditis (AFM) is a disease category that is easily neglected. Circulatory mechanical support is sometimes required for this devastating condition...
  26. ncbi Pathology of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salar
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    Dis Aquat Organ 59:217-24. 2004
    ..Microscopic lesions are compared and discussed in relation to published descriptions of pancreas disease (PD) and cardiomyopathy syndrome (CMS). It is concluded that HSMI is histopathologically distinguishable from PD and CMS...
  27. ncbi Expression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis
    M Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Japan
    J Am Coll Cardiol 36:1288-94. 2000
    We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis.
  28. ncbi Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results
    R Wojnicz
    Silesian Center of Heart Disease, Zabrze, Poland
    Circulation 104:39-45. 2001
    ..Thus, restoration of immunosuppressive therapy for such patients should be considered...
  29. ncbi T(1) mapping for the diagnosis of acute myocarditis using CMR: comparison to T2-weighted and late gadolinium enhanced imaging
    Vanessa M Ferreira
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    JACC Cardiovasc Imaging 6:1048-58. 2013
    This study sought to test the diagnostic performance of native T1 mapping in acute myocarditis compared with cardiac magnetic resonance (CMR) techniques such as dark-blood T2-weighted (T2W)-CMR, bright-blood T2W-CMR, and late gadolinium ..
  30. ncbi Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Life Sci 90:289-300. 2012
    ..We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM].
  31. pmc Immunohistochemical detection of piscine reovirus (PRV) in hearts of Atlantic salmon coincide with the course of heart and skeletal muscle inflammation (HSMI)
    Oystein Wessel Finstad
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Postboks 8146 Dep, N 0033 OSLO Norwegian, Norway
    Vet Res 43:27. 2012
    ..The disease is characterized by epi-, endo- and myocarditis, myocardial necrosis, myositis and necrosis of the red skeletal muscle...
  32. ncbi Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 46:154-63. 2012
    ..that treatment with quercetin at a dose of 10 mg/kg protects from the progression of experimental autoimmune myocarditis (EAM) to dilated cardiomyopathy (DCM), we have used the rat model of EAM induced by porcine cardiac myosin...
  33. ncbi HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion
    Zhaoliang Su
    Department of Immunology, Jiangsu University, Zhenjiang, PR China
    Eur J Immunol 41:3586-95. 2011
    ..DCM), one of the leading causes of heart failure, is often caused by coxsackievirus B3-triggered myocarditis and promoted by the post-infectious autoimmune process...
  34. ncbi Myocarditis
    Sandeep Sagar
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Lancet 379:738-47. 2012
    b>Myocarditis is an underdiagnosed cause of acute heart failure, sudden death, and chronic dilated cardiomyopathy...
  35. pmc Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis
    Elisa Opitz
    Medizinische Klinik für Kardiologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Pathog 7:e1002233. 2011
    ..Here, we report on the role of IPs in acute coxsackievirus B3 (CVB3) myocarditis reflecting one of the most common viral disease entities among young people...
  36. ncbi Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells
    Kun Lv
    Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, PR China
    Clin Immunol 140:92-101. 2011
    In this study we explored the effects of galectin-9 on CVB3 induced myocarditis and its possible mechanisms involved...
  37. ncbi Detection of enterovirus capsid protein VP1 in myocardium from cases of myocarditis or dilated cardiomyopathy by immunohistochemistry: further evidence of enterovirus persistence in myocytes
    Hongyi Zhang
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, UK
    Med Microbiol Immunol 193:109-14. 2004
    ..This retrospective study investigated the involvement of enterovirus in myocarditis or dilated cardiomyopathy (DCM) by detection of viral antigens in myocardial samples from a new patient series ..
  38. ncbi Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response
    Matthias Pauschinger
    Department of Internal Medicine II, Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Heart Fail 7:444-52. 2005
    ..Beta-adrenergic receptor stimulation influences the production of cytokines heralding the possibility of modulating cytokine production by beta-adrenergic blockers...
  39. ncbi CD69 limits the severity of cardiomyopathy after autoimmune myocarditis
    Aranzazu Cruz-Adalia
    Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernandez Almagro, Madrid, Spain
    Circulation 122:1396-404. 2010
    Experimental autoimmune myocarditis (EAM), a mouse model of post-infectious cardiomyopathy, reflects mechanisms of inflammatory cardiomyopathy in humans...
  40. ncbi Acute myocarditis in dengue hemorrhagic fever: a case report and review of cardiac complications in dengue-affected patients
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Int J Infect Dis 14:e919-22. 2010
    We report a case of dengue hemorrhagic fever (DHF) complicated by acute myocarditis and review the literature...
  41. ncbi Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy
    Michel Noutsias
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Eur J Heart Fail 13:611-8. 2011
    To quantify and functionally characterize the intramyocardial T-cells in endomyocardial biopsies (EMBs) from patients presenting with acute myocarditis (AMC) and dilated cardiomyopathy (DCM).
  42. pmc Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 165:1883-94. 2004
    Inflammatory fibrosis is a characteristic feature of myocarditis, dilated cardiomyopathy (DCM), and congestive heart failure...
  43. ncbi Tenascin-C is a useful marker for disease activity in myocarditis
    Kyoko Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Japan
    J Pathol 197:388-94. 2002
    ..This study examined the diagnostic value of TNC for assessing disease activity of myocarditis. Expression of TNC was examined in myosin-induced autoimmune myocarditis mouse models...
  44. ncbi Cardiomyocyte apoptosis in experimental coxsackievirus B3 myocarditis
    Antti Saraste
    Department of Anatomy, University of Turku, Turku, Finland
    Cardiovasc Pathol 12:255-62. 2003
    ..We studied whether cardiomyocyte apoptosis occurs upon coxsackievirus B3 (CVB3) infection and whether virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis.
  45. ncbi Cardiac troponin T: a marker in the diagnosis of acute myocarditis in children
    J Soongswang
    Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, 2 Prannok Road, Bangkok, 10700, Thailand
    Pediatr Cardiol 26:45-9. 2005
    ..to assess the use of serum cardiac troponin T (cTnT) level as a noninvasive indicator to diagnose acute myocarditis in children. Noninvasive conventional methods often fail to diagnose myocarditis, A median cTnT level of 0...
  46. ncbi CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis
    Alan Valaperti
    Experimental Critical Care Medicine, Department of Research, University Hospital, Petersgraben 4, Basel, Switzerland
    J Immunol 180:2686-95. 2008
    Experimental autoimmune myocarditis (EAM) represents a Th17 T cell-mediated mouse model of postinflammatory heart disease...
  47. ncbi T2-weighted cardiovascular magnetic resonance imaging
    Hassan Abdel-Aty
    Franz Volhard Klinik and Department of Radiology, Charite University Hospital, Berlin, Germany
    J Magn Reson Imaging 26:452-9. 2007
    ..In this article, we review technical considerations and discuss clinical indications of myocardial T2-weighted imaging...
  48. ncbi From infection to autoimmunity
    D Fairweather
    The Department of Pathology and The W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins University, Baltimore, Maryland, USA
    J Autoimmun 16:175-86. 2001
    We have investigated two models of virally-induced autoimmune myocarditis in mice using widely different infectious agents...
  49. ncbi T cells expressing the gamma delta T cell receptor induce apoptosis in cardiac myocytes
    S A Huber
    Department of Pathology, University of Vermont, Colchester 05446, USA
    Cardiovasc Res 45:579-87. 2000
    Enterovirus infections are major etiological factors in myocarditis and dilated cardiomyopathy...
  50. ncbi Myocarditis: current trends in diagnosis and treatment
    Jared W Magnani
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Circulation 113:876-90. 2006
  51. pmc Cardiac myosin autoimmunity in acute Chagas' heart disease
    J S Leon
    Department of Pathology and Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Infect Immun 69:5643-9. 2001
    ..cruzi infection. A/J mice infected with the Brazil strain of T. cruzi for 21 days developed severe myocarditis, accompanied by humoral and cellular autoimmunity. Specifically, T...
  52. ncbi Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice
    Roland Zell
    Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
    Med Microbiol Immunol 193:91-100. 2004
    ..CVB3-infected NMRI outbred mice showed significantly reduced signs of myocarditis after treatment with GTN or ISDN...
  53. pmc Low dose carvedilol inhibits progression of heart failure in rats with dilated cardiomyopathy
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Kamisin ei cho, Niigata 950 2081, Japan
    Br J Pharmacol 130:1489-95. 2000
    ..beta-adrenoceptor blocking agent) were studied in a rat model of dilated cardiomyopathy induced by autoimmune myocarditis. Twenty-eight days after immunization, surviving Lewis rats (32/43=74%) were divided into three groups to be ..
  54. pmc IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis
    Nir Grabie
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 111:671-80. 2003
    Cardiac antigen-specific CD8(+) T cells are involved in the autoimmune component of human myocarditis. Here, we studied the differentiation and migration of pathogenic CD8(+) T cell effector cells in a new mouse model of autoimmune ..
  55. pmc Diagnosis and treatment of viral myocarditis
    Jason C Schultz
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:1001-9. 2009
    b>Myocarditis, an inflammatory disease of heart muscle, is an important cause of dilated cardiomyopathy worldwide...
  56. pmc Vgamma4(+) T cells promote autoimmune CD8(+) cytolytic T-lymphocyte activation in coxsackievirus B3-induced myocarditis in mice: role for CD4(+) Th1 cells
    S A Huber
    Department of Pathology, University of Vermont, Burlington, Vermont, USA
    J Virol 76:10785-90. 2002
    T cells expressing the Vgamma4 T-cell receptor (TCR) promote myocarditis in coxsackievirus B3 (CVB3)-infected BALB/c mice...
  57. ncbi Regulated on activation, normal T cell expressed and secreted (RANTES) antagonist (Met-RANTES) controls the early phase of Trypanosoma cruzi-elicited myocarditis
    Ana Paula M P Marino
    Department of Immunology, IOC FIOCRUZ, Rio de Janeiro, Brazil
    Circulation 110:1443-9. 2004
    Comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate strategies aimed at ameliorating the inflammation associated with heart dysfunction...
  58. ncbi Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study
    Andrea Frustaci
    Cardiovascular and Respiratory Sciences Department, La Sapienza University, Viale del Policlinico 155, Rome 00161, Italy
    Eur Heart J 30:1995-2002. 2009
    ..To evaluate the efficacy of immunosuppression in virus-negative inflammatory cardiomyopathy...
  59. ncbi The management of myocarditis
    Heinz Peter Schultheiss
    Charite Hospital, Berlin, Germany
    Eur Heart J 32:2616-25. 2011
    Despite considerable advances in our understanding of myocarditis pathogenesis, the clinical management of myocarditis has changed relatively little in the last few years...
  60. ncbi High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction
    Uwe Kuhl
    Charite University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200 Berlin, Germany
    Circulation 111:887-93. 2005
    For a long time, enteroviruses have been considered to be the most common cause of acute viral myocarditis (MC), with possible transition from MC to dilated cardiomyopathy (DCM)...
  61. pmc Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity
    Delisa Fairweather
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Methods 41:118-22. 2007
    ..A significant proportion of heart disease in Western populations is associated with inflammation. Myocarditis, or inflammation of the heart muscle, is the major cause of sudden death in young adults...
  62. pmc A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy
    Carlos Gorbea
    Department of Pediatrics Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Biol Chem 285:23208-23. 2010
    ..and the absence of TLR3 in mice significantly increases mortality after infection with enteroviruses that cause myocarditis and/or dilated cardiomyopathy...
  63. ncbi Effects of free immunoglobulin light chains on viral myocarditis
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Circ Res 106:1533-40. 2010
    In recent work, we have demonstrated a crucial role of mast cells in the development of viral myocarditis. Viral infection could lead to increased synthesis of free immunoglobulin light chains (FLC) and our earlier work showed that FLC ..
  64. ncbi Chinese medicinal herb Radix Astragali suppresses cardiac contractile dysfunction and inflammation in a rat model of autoimmune myocarditis
    Peng Zhao
    Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan 250021, PR China
    Toxicol Lett 182:29-35. 2008
    ..myocardial dysfunction, cardiac remodeling and morphological alteration in an experimental model of autoimmune myocarditis, a clinical condition often resulting in dilated cardiomyopathy...
  65. ncbi Pathogenesis of myocarditis and dilated cardiomyopathy
    Daniela Cihakova
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Adv Immunol 99:95-114. 2008
    b>Myocarditis is a disease with a variable clinical presentation, ranging from asymptomatic to a fatal outcome...
  66. ncbi Cardiac magnetic resonance monitors reversible and irreversible myocardial injury in myocarditis
    Anja Zagrosek
    Franz Volhard Klinik, Kardiologie, Charite Campus Buch, HELIOS Klinikum Berlin, Universitatsmedizin Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 2:131-8. 2009
    We sought to assess the value of cardiac magnetic resonance (CMR) to monitor the spectrum of myocarditis-related injuries over the course of the disease.
  67. ncbi The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries
    Ravi G Assomull
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London SW3 6NP, UK
    Eur Heart J 28:1242-9. 2007
    ..However, some patients have no coronary obstruction on angiography, leading to diagnostic uncertainty. We evaluated the incremental diagnostic value of cardiovascular magnetic resonance (CMR) in these patients...
  68. pmc A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
    Hideo Negishi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:20446-51. 2008
    ..TLR3-deficient mice show a vulnerability to CVB3, accompanied by acute myocarditis, whereas transgenic expression of TLR3 endows even type I IFN signal-deficient mice resistance to CVB3 and ..
  69. ncbi Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development
    Nisha Garg
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Biochim Biophys Acta 1638:106-20. 2003
    In this study, we report the host genetic responses that characterize Trypanosoma cruzi-induced myocarditis in a murine model of infection and disease development...
  70. ncbi Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis
    Kang Li
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    Circ Res 105:353-64. 2009
    Myocardial infiltrating macrophages play an important role in the pathogenesis of viral myocarditis in male BALB/c mice following coxsackievirus B3 (CVB3) infection...
  71. pmc Fatal encephalitis and myocarditis in young domestic geese (Anser anser domesticus) caused by West Nile virus
    D E Swayne
    U S Department of Agriculture, Agricultural Research Service, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30605, USA
    Emerg Infect Dis 7:751-3. 2001
    ..caused depression, weight loss, torticollis, opisthotonus, and death with accompanying encephalitis and myocarditis. Based on this experimental study and a field outbreak in Israel, WN virus is a disease threat to young ..
  72. ncbi Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines
    Hideki Futamatsu
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ Res 96:823-30. 2005
    ..We examined the influence of HGF on T cells and the effects of HGF therapy in acute myocarditis. Lewis rats were immunized on day 0 with cardiac myosin to establish experimental autoimmune myocarditis (EAM)...
  73. pmc MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi
    Aruna K Behera
    New England Medical Center, Box 41, 750 Washington St, Boston, MA 02111
    Infect Immun 74:1462-70. 2006
    ..burgdorferi and inducing these chemokines are present in the muscle and kidneys. Interleukin-18 signaling through MyD88 does not appear to play a role in either control of infection or inflammation...
  74. ncbi Persistent coxsackievirus infection: enterovirus persistence in chronic myocarditis and dilated cardiomyopathy
    N M Chapman
    University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Curr Top Microbiol Immunol 323:275-92. 2008
    Enteroviral infection of the heart has been noted in a significant proportion of cases of myocarditis and dilated cardiomyopathy...
  75. pmc An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain
    Raina T Gay
    Nutritional Immunology Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 103:13825-30. 2006
    ..These results demonstrate that the aged host promotes rapid selection of a pathogenic variant of CVB3 from an avirulent strain and introduces a host-virus paradigm for studies of viral infection in the aged...
  76. ncbi Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection
    M A Opavsky
    Centre for Cardiovascular Research, The Toronto Hospital, University of Toronto, Toronto, Ontario, Canada
    Circ Res 85:551-8. 1999
    Viral myocarditis is an important cause of heart failure and dilated cardiomyopathy. T lymphocytes are implicated in myocardial damage in murine models of coxsackievirus B3 (CVB3) myocarditis...
  77. pmc Children with fulminant myocarditis rescued with extracorporeal membrane oxygenation
    E T Wu
    Heart 92:1325-6. 2006
  78. ncbi Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus-induced myocarditis
    Delisa Fairweather
    The Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Rev Med Virol 15:17-27. 2005
    ..TLR4 signalling also increases acute myocarditis and proinflammatory cytokines in the heart...
  79. ncbi Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy
    Veronika Nindl
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Eur J Immunol 42:2311-21. 2012
    b>Myocarditis is a potentially lethal inflammatory heart disease of children and young adults that frequently leads to dilated cardiomyopathy (DCM)...
  80. pmc Mesenchymal stromal cells but not cardiac fibroblasts exert beneficial systemic immunomodulatory effects in experimental myocarditis
    Konstantinos Savvatis
    Department of Cardiology and Pneumology, Campus Benjamin Franklin CBF, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e41047. 2012
    ..We therefore investigated the regulation of the immune response in coxsackievirus B3 (CVB3)-induced acute myocarditis after intravenous application of MSCs...
  81. pmc Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis
    Alice Weithäuser
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Berlin, Germany Institute for Chemistry Biochemistry, Freie Universitat Berlin, Berlin, Germany
    J Am Coll Cardiol 62:1737-45. 2013
    This study sought to evaluate the role of protease-activated receptor-2 (PAR2) in coxsackievirus B3 (CVB3)-induced myocarditis.
  82. ncbi Viral heart disease: molecular diagnosis, clinical prognosis, and treatment strategies
    Matthias Pauschinger
    Department of Cardiology, Medical Clinic II, Charite, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Med Microbiol Immunol 193:65-9. 2004
    b>Myocarditis is considered as a potent predisposing factor for dilated cardiomyopathy (DCM)...
  83. pmc Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Int J Biol Sci 7:1077-92. 2011
    ..effects of telmisartan, a well-known angiotensin receptor blockers (ARBs) against experimental autoimmune myocarditis (EAM). EAM was induced in Lewis rats by immunization with porcine cardiac myosin...
  84. ncbi IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis
    Tomomi Yamashita
    Department of Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Science, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cardiovasc Res 91:640-8. 2011
    ..Th17) cells have been proposed to participate in the pathogenesis of chronic inflammation, such as autoimmune myocarditis. IL-6 gene ablation confers the resistance to experimental autoimmune myocarditis (EAM)...
  85. ncbi Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders
    Andrea Frustaci
    Department of Cardiology, Catholic University, Rome, Italy
    Circulation 107:857-63. 2003
    The beneficial effect of immunosuppressive treatment on myocarditis is still controversial, possibly because the immunologic and virological profile of potential candidates is largely unknown.
  86. ncbi Myocarditis associated with reovirus in turkey poults
    H L Shivaprasad
    California Animal Health and Food Safety Laboratory System, University of California, Davis, Davis, California, USA
    Avian Dis 53:523-32. 2009
    b>Myocarditis associated with reovirus was diagnosed in 17-day-old, male turkey poults, based on virus isolation, reverse transcriptase-polymerase chain reaction (RT-PCR), demonstration of reovirus antigen in the cytoplasm of mononuclear ..
  87. ncbi Mechanical circulatory support for the treatment of children with acute fulminant myocarditis
    B W Duncan
    Division of Cardiac Surgery, Children's Hospital and Regional Medical Center, University of Washington, School of Medicine, Seattle, Wash, USA
    J Thorac Cardiovasc Surg 122:440-8. 2001
    BACKGROUND: Viral myocarditis may follow a rapidly progressive and fatal course in children...
  88. ncbi Role of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis
    Christoph Leib
    Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Circ Res 109:130-40. 2011
    This study was performed to gain insights into novel therapeutic approaches for the treatment of autoimmune myocarditis.
  89. ncbi Myocarditis: infection versus autoimmunity
    Noel R Rose
    Departments of Pathology and of Molecular Microbiology and Immunology, Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, Room 659, Baltimore, MD 21205, USA
    J Clin Immunol 29:730-7. 2009
    b>Myocarditis, which is the inflammation of the heart muscle, remains a vexing therapeutic problem...
  90. ncbi Subclinical rheumatic valvitis: a long-term follow-up
    Cristina Costa Duarte Lanna
    Division of Paediatric Cardiology, Department of Paediatrics, Hospital das Clinicas, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Cardiol Young 13:431-8. 2003
    ....
  91. pmc Prospective comparison of clinical and echocardiographic diagnosis of rheumatic carditis: long term follow up of patients with subclinical disease
    F E Figueroa
    Facultad de Medicina, Universidad de Los Andes, Avenida San Carlos de Apoquindo 2200, Santiago de Chile, Chile
    Heart 85:407-10. 2001
    ..To determine the frequency of occurrence and long term evolution of subclinical carditis in patients with acute rheumatic fever...
  92. ncbi Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice
    Kanjo Yamamoto
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 42:2000-6. 2003
    This study examined the role of angiotensin II (Ang-II) in a murine model of viral myocarditis.
  93. ncbi Inflammation in dilated cardiomyopathy
    Sabine Pankuweit
    Department of Internal Medicine Cardiology, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Herz 29:788-93. 2004
    ..inflammatory component in the pathogenesis of dilated cardiomyopathy (DCM), and there is growing evidence, that myocarditis and DCM are closely related...
  94. ncbi Inhibition of mast cells by interleukin-10 gene transfer contributes to protection against acute myocarditis in rats
    Suresh S Palaniyandi
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Eur J Immunol 34:3508-15. 2004
    Progression of acute myocarditis involves a variety of inflammatory events. Mast cells have been implicated as the source of various cytokines, chemokines and histamine in acute inflammation and fibrosis...
  95. ncbi Quantitative trait locus analysis, pathway analysis, and consomic mapping show genetic variants of Tnni3k, Fpgt, or H28 control susceptibility to viral myocarditis
    Sean A Wiltshire
    Department of Human Genetics, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Immunol 186:6398-405. 2011
    Coxsackievirus B3 (CVB3) infection is the most common cause of viral myocarditis. The pathogenesis of viral myocarditis is strongly controlled by host genetic factors...
  96. ncbi Glutathione peroxidase protects mice from viral-induced myocarditis
    M A Beck
    Frank Porter Graham Child Development Center, University of North Carolina at Chapel Hill, 27599 8180, USA
    FASEB J 12:1143-9. 1998
    ..Previous investigations determined that mice deficient in selenium developed myocarditis when infected with a benign strain of coxsackievirus B3 (CVB3/0)...
  97. pmc PET/MRI of inflammation in myocardial infarction
    Won Woo Lee
    Center for Systems Biology, Massachusetts General Hospital, Boston, USA
    J Am Coll Cardiol 59:153-63. 2012
    ..The aim of this study was to explore post-myocardial infarction (MI) myocardial inflammation...
  98. pmc Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance
    J R Gebhard
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 153:417-28. 1998
    Viral myocarditis is remarkably common, being detected in approximately 1% of unselected asymptomatic individuals. Many cases are attributable to enteroviral infection, and in particular to coxsackievirus B3...
  99. ncbi Influenza myocarditis and myositis: case presentation and review of the literature
    Kanwal Kumar
    Institute of Cardiovascular Sciences, St Boniface Research Centre, Winnipeg, Manitoba, Canada
    Can J Cardiol 27:514-22. 2011
    b>Myocarditis, a general inflammatory condition of the heart muscle, can result from a variety of etiologies, the most common being viral. Despite common pathogens, concomitant myocarditis and myositis remains a rare event...
  100. ncbi Fulminant myocarditis associated with novel H1N1 influenza A
    Rami N Khouzam
    Division of Cardiology, Winthrop University Hospital, Mineola, New York 11501, USA
    Heart Lung 40:566-8. 2011
    b>Myocarditis secondary to H1N1 influenza has been described in children, but only very rarely in adults. We describe a 36-year-old man with no significant medical history who presented with flu-like symptoms of 3-week duration...
  101. ncbi Clinical features and outcomes of eosinophilic myocarditis patients treated with prednisolone at a single institution over a 27-year period
    Sayaka Kawano
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan
    Intern Med 50:975-81. 2011
    Eosinophilic myocarditis is a rare clinical entity characterized by eosinophilia and myocardial inflammation with infiltrating eosinophils...

Research Grants64

  1. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..of diseases in human and veterinary medicine, including polyarthritis, cutaneous vasculitis, endocarditis, myocarditis, epistaxis, peliosis hepatis, granulomatous inflammatory disease, and, most recently, neurological dysfunction ..
  2. Enterovirus RNA Translation and Replication
    David J Barton; Fiscal Year: 2013
    ..spectrum of human diseases including acute flaccid paralysis (paralytic poliomyelitis), aseptic meningitis, myocarditis, conjunctivitis and fatal systemic infections of neonates...
  3. Autoimmunity in the Mediation of Infectious Myocarditis
    Jay Reddy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heart disease is the leading cause of death in humans, and myocarditis is a predominant cause of heart failure in young adolescents...
  4. Sex Differences in Complement during Myocarditis/DCM
    Delisa Fairweather; Fiscal Year: 2013
    ..Men have a higher incidence and severity of cardiovascular diseases (CVDs) including myocarditis/dilated cardiomyopathy (DCM) and heart failure than women...
  5. Role of Lipoproteins in Chagasic heart disease
    JYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013
    ..Chagasic heart disease is characterized by myocarditis associated with prominent fibrotic scarring, cardiac hypertrophy, arrhythmia, cardiomyopathy, heart failure and ..
  6. control of Inflammation by regulatory T cells and BCL6
    Alexander L Dent; Fiscal Year: 2012
    ..BCL6 as a novel regulatory mediator of T-reg activity can offer new insights into the molecular etiology of myocarditis and vasculitis, thus facilitating the development of new therapies targeting BCL6 for treatment of inflammation ..
  7. Transcriptional control of chemokine receptors and naive T cell trafficking
    Eric Sebzda; Fiscal Year: 2013
    ..as well as clinical conditions such as pathogen clearance and T cell-mediated diseases like autoimmune myocarditis. Public Health Relevance: T lymphocytes mediate immune responses, both desired (such as clearance of disease-..
  8. Regulation of reovirus induced apoptosis
    John S Parker; Fiscal Year: 2012
    ..Reoviruses cause pathologic damage (myocarditis and encephalitis) by inducing apoptosis...
  9. Origin and Function of Inflammatory Dendritic Cells in Psoriasis.
    Michelle A Lowes; Fiscal Year: 2013
    ..becoming inflammatory DCs and macrophages in murine models, including colitis, infections, atherosclerosis, and myocarditis. Although much less in known in humans, circulating CD16+ monocytes are elevated in psoriasis and other many ..
  10. Cell Biology of Enterovirus Infection in Polarized Epithelial Cells
    Jeffrey M Bergelson; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Enteroviruses are the major cause of viral meningitis, and the second major cause of myocarditis in the US, and interaction with polarized epithelium is the first step in infection...
  11. Genetic mechanisms of autoimmune myocarditis
    Noel Rose; Fiscal Year: 2009
    Autoimmune myocarditis develops due to an immune response to cardiac-specific antigens expressed in the heart. The MHC is important in determining susceptibility to autoimmune myocarditis;however other genetic factors are also critical...
  12. Eosinophilic Myocarditis
    Noel R Rose; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eosinophilic myocarditis is a rare form of myocarditis with a poorly understood pathogenesis and an exceptionally poor prognosis...
  13. Mucosal dendritic cell function following enteric virus infection
    Christopher F Cuff; Fiscal Year: 2010
    ..Besides gastroenteritis, other diseases caused by enteric viruses include hepatitis, myocarditis, and inflammation of the central nervous system...
  14. Enterovirus infection of polarized intestinal cells
    Carolyn B Coyne; Fiscal Year: 2013
    ..of diverse syndromes, including meningitis, pericarditis, febrile illness, diabetes, dilated cardiomyopathy and myocarditis. A key event in CVB pathogenesis is the induction of host cell death...
  15. Mechanisms of B cell activation by Complement Receptor 2
    Taras Lyubchenko; Fiscal Year: 2013
    ..activation of B cells is important in autoimmune diseases such as rheumatoid arthritis, lupus and myocarditis where complement and antibodies play important role in pathogenesis...
  16. Autoimmune Determinants of Human Cardiac Myosin
    Madeleine W Cunningham; Fiscal Year: 2013
    Abstract: Myocarditis and rheumatic carditis are sequelae of viral or bacterial infections, respectively, and occur in humans and animal models following viral infection, group A streptococcal infection, or immunization with cardiac ..
  17. Enterovirus RNA Translation and Replication
    David Barton; Fiscal Year: 2009
    ..spectrum of human diseases including acute flaccid paralysis (paralytic poliomyelitis), aseptic meningitis, myocarditis, conjunctivitis and fatal systemic infections of neonates...
  18. Reovirus modulation of the cardiac innate response: Type I interferon and HSP25
    Barbara Sherry; Fiscal Year: 2013
    ..Indeed, we have shown that the cardiac interferon (IFN) response is unique, and that in reovirus-induced murine myocarditis the IFN response differs between virus strains and is critical for protection...
  19. NLRP1 activation induces deletion of hematopoietic progenitor cells
    BEN ADAM CROKER; Fiscal Year: 2013
    ..Nlrp1aQ593P/Q593P mice develop lethal meningoencephalitis, pneumonitis and myocarditis. This disease is dependent on IL-1[unreadable] and Caspase-1 but not ASC or Caspase-11 and is unexpectedly, ..
  20. Innate and Adaptive Immune Responses in the Virus-Infected Heart
    J Lindsay Whitton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxsackieviruses are the commonest infectious cause of acute myocarditis, a disease that causes substantial human morbidity and mortality...
  21. Receptors and Signals in Coxsackievirus Pathogenesis
    Jeffrey M Bergelson; Fiscal Year: 2011
    ..in cultured intestinal epithelium, determine whether calpain activation contributes to the pathogenesis of myocarditis and pancreatitis in infected animals, and test whether calpain inhibitors reduce the severity of disease...
  22. Reovirus Modulation of the Cardiac Innate Response: Type I Interferon and HSP25
    Barbara Sherry; Fiscal Year: 2009
    ..we have shown that the cardiac Type I interferon (IFN) response is unique, and that in reovirus-induced murine myocarditis the IFN response differs between virus strains and is critical for protection...
  23. 5'End Genomic Deletions and Enterovirus Persistence
    Nora M Chapman; Fiscal Year: 2012
    ..term effects upon heart function including debilitating conditions such as dilated cardiomyopathy and chronic myocarditis. Understanding how selection of these variant viruses occurs and how these viruses replicate will provide the ..
  24. Adenovirus myocarditis: defining host factors contributing to pathogenesis
    JASON BRICE WEINBERG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute myocarditis is a significant cause of disease in children and adults...
  25. COXSACKIE MYOCARDITIS AND VIRAL PERSISTENCE IN THE HEART
    J Lindsay Whitton; Fiscal Year: 2013
    Coxsackievirus B3 causes myocarditis, pancreatitis and meningo-encephalitis but, despite the resulting human morbidity and mortality, neither a treatment, nor a vaccine, is available...
  26. Functional biology of Il-25
    Steven A Saenz; Fiscal Year: 2010
    ..expansion of T helper (TH) 17 populations has been implicated in numerous inflammatory diseases such as myocarditis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and asthma...
  27. Role of the Thrombin PAR-1 Pathway in Viral Infection
    Nigel Mackman; Fiscal Year: 2013
    ..of TF or thrombin, as well as a deficiency of PAR-1 significantly increased coxsackievirus B3 (CVB3)-induced myocarditis. PAR-1 deficient mice were also more susceptible to infection with influenza A...
  28. Structural Studies of Virus and Receptor Interaction
    Susan Hafenstein; Fiscal Year: 2010
    ..Relevance: Picornaviruses cause severe myocarditis, aseptic meningitis and are implicated in diabetes...
  29. Defining mechanisms underlying Listeria monocytogenes cardiac infections
    NANCY ELIZABETH FREITAG; Fiscal Year: 2013
    ..These studies will provide a detailed understanding of the pathogenesis and maturation of myocarditis resulting from Lm infection, and will clarify bacterial factors that contribute to specific host tisue tropisms...
  30. Picornavirus-initiated inflamation: novel parallels from Drosophila
    Siddharth Balachandran; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Virus infections are recognized as a major cause of myocarditis (or inflammation of the heart muscle), and chronic myocarditis often leads to more severe cardiac disease (including dilated ..
  31. Late Gadolinium Enhancement MRI for Patients with Implantable Cardiac Devices
    Peng Hu; Fiscal Year: 2013
    ..means of accurately diagnosing and differentiating various forms of non-ischemic cardiomyopathy, including myocarditis, arrhythmogenic right ventricular dysplasia, amyloidosis, and sarcoidosis...
  32. Tregulatory cells in myocarditis
    Sally A Huber; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myocarditis is an inflammation of the heart muscle which often follows microbial infections and evidence indicates that autoimmunity to heart antigens contributes to cardiac injury...
  33. The Role of dsRNA Sensors in Viral Myocarditis
    Stephen McCartney; Fiscal Year: 2010
    b>Myocarditis is an inflammatory disease in which the heart becomes injured in the absence of an ischemic event. In the US, most cases of myocarditis are caused by viruses...
  34. Role of Natural Killer Cells in Myocarditis and Dilated Cardiomyopathy
    Sufey Ong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Myocarditis, the inflammation of the heart muscle, is a one of the leading causes of cardiac-related deaths in individuals under the age of 40...
  35. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    James Bert Flanegan; Fiscal Year: 2010
    ..Diseases associated with these viruses include paralytic poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold...
  36. Innate Immunity in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Myocarditis is an inflammation of the myocardium which often follows microbial infections. Enteroviruses (picornaviruses) and adenoviruses are most frequently implicated in clinical disease...
  37. Peptide Vaccine for Experimental Autoimmune Myocarditis
    Daniel Zimmerman; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): In A/J Mice Experimental Autoimmune Myocarditis (EAM) can be induced by infection with coxsackie virus B 3 or by immunization with murine or porcine cardiac myosin or a cardiogenic peptide from ..
  38. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
    ..is cardiac injury which includes varying degrees of atrioventricular (AV) block, most often third degree, and myocarditis. The mortality approaches 20% and the majority of children require lifelong pacing...
  39. Genetic Risk for Smallpox Vaccine Related to Myocarditis
    Deborah A Nickerson; Fiscal Year: 2010
    ..This contract will study the genetic risk for smallpox vaccine related to myocarditis
  40. Poxvirus adverse effects on cardiac cells and the heart
    Barbara Sherry; Fiscal Year: 2005
    ..Notably, myocarditis has been diagnosed in 18 recent smallpox vaccinees in the USA...
  41. CAR PROTEIN AND AUTO IMMUNITY
    Robert Finberg; Fiscal Year: 2002
    ..Many auto-immune diseases are thought to be triggered by viral infections. In particular auto-immune diabetes and myocarditis are said to follow infections with enteroviruses...
  42. GENETIC ANALYSIS OF PICORNAVIRUS RNA REPLICATION IN VIVO
    JAMES FLANEGAN; Fiscal Year: 2006
    ..Some of the diseases associated with these viruses include meningitis, encephalitis, poliomyelitis, myocarditis, respiratory infections and hepatitis...
  43. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
    ..Chagas' disease caused by the protozoan parasite Trypanosoma cruzi, is an important cause of acute myocarditis and chronic cardiomyopathy in endemic regions of Latin America...
  44. Transgenic Mouse Model for Echovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2004
    ..Echoviruses are important human pathogens and are responsible for aseptic meningitis, neonatal sepsis, myocarditis, exanthemas, respiratory illness and gastrointestinal disease...
  45. TRANSLATION-INHIBITION OF HEPATITIS C AND POLIO VIRUSES
    Asim Dasgupta; Fiscal Year: 2003
    ..A) and chronic hepatitis (hepatitis C), common cold (rhinovirus), and myocarditis and encephalitis (coxsackie) among others...
  46. T cell costimulation and regulation in myocarditis
    Andrew Lichtman; Fiscal Year: 2006
    Auotimmune myocarditis, which can occur after viral infection, underlies many cases of dilated cardiomyopathy...
  47. Role of TLR3-TRIF Variants in host susceptibility to viral myocarditis
    NEIL BOWLES; Fiscal Year: 2009
    Viral heart disease (myocarditis and dilated cardiomyopathy (DCM)) are important causes of morbidity and mortality...
  48. Evaluating dendritic cell activation and function during coxsackievirus infection
    CHRISTOPHER KEMBALL; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Type B coxsackieviruses (CVB) are the most common infectious cause of myocarditis, a serious disease that can lead to dilated cardiomyopathy and cardiac failure...
  49. Role of autoimmunity in transplant rejection
    Gilles Benichou; Fiscal Year: 2007
    ..CM is known to initiate autoimmune myocarditis, an autoimmune disease causing cardiac tissue damage and heart failure...
  50. IMMUNOSUPPRESSIVE THERAPY FOR BIOPSY-PROVEN MYOCARDITIS
    Jay Mason; Fiscal Year: 1991
    ..research study designed to determine if immunosuppressive treatment improves cardiac function in patients with myocarditis documented by endomyocardial biopsy. Patients with unexplained cardiac dysfunction will undergo cardiac biopsy...
  51. PHYSICAL BASIS OF T CELL ACTIVATION BY SUPERANTIGENS
    Roy Mariuzza; Fiscal Year: 2000
    ..indicates that infections play an important role in the induction of autoimmune disorders such as autoimmune myocarditis and diabetes mellitus...
  52. MECHANISMS OF COCAINE INDUCED EXACCERBATION OF VIRAL MYO
    James Morgan; Fiscal Year: 2003
    ..cocaine abusers have an increased incidence of Human Immunodeficiency Virus (HIV) infection and HIV-related myocarditis. These data indicate a causal relationship between cocaine use and myocarditic viral pathogenicity, which we ..
  53. The Scientific Basis of Heart Failure in the Young
    RONALD PAYNE; Fiscal Year: 2007
    ..In addition, inherited cardiomyopathies, and acquired heart disease, such as myocarditis, contribute to the overall burden of HF in the young...
  54. MYOCARDITIS--RECEPTORS FOR A CARDIOTROPIC VIRUS
    Jeffrey Bergelson; Fiscal Year: 2001
    Viral myocarditis is believed to initiate the pathologic processes that lead to nearly 9,000 deaths from dilated cardiomyopathy in the US each year...
  55. MECHANISMS OF PICORNAVIRUS AUTOIMMUNITY
    JOHN CRAIGHEAD; Fiscal Year: 1990
    ..in this program will address this specific issue in using three well characterized models of human disease (myocarditis and congestive myocardopathy, demyelinating encephalomyelitis, and Type I diabetes mellitus)-induced with a ..
  56. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..Additionally, with clozapine, cardiomyopathy, cardiac arrhythmias, and myocarditis are known to occur...
  57. PCR ANALYSIS OF CARDIAC INFLAMMATION AND VIRAL INFECTION
    KENNETH SCHOWENGERDT; Fiscal Year: 1999
    ..Acute myocarditis typically presents with severe clinical manifestations and, unfortunately, in many cases cardiac dysfunction is ..
  58. Molecular Mechanisms of Autoimmune Heart Disease
    Myra Lipes; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Autoimmune myocarditis is a major cause of sudden death in children and young adults. Although widely thought to be of infectious etiology, in the majority of cases the cause of disease is unknown...
  59. POSTINFECTIOUS AUTOIMMUNITY
    Noel Rose; Fiscal Year: 1999
    Through the development of mouse models of coxsackievirus B3 (CB3)-induced and cardiac myosin-induced autoimmune myocarditis, we have shown that modulation of cytokines, IL-1, TNF-alpha and IFN-gamma affects the severity of both virus ..
  60. NOVEL SIGNALING PATHWAYS FOR ANGIOTENSIN II IN THE HEART
    Kenneth Baker; Fiscal Year: 2002
    ..plays an important role in cardiac and vascular pathology associated with hypertension, coronary heart disease, myocarditis and congestive heart failure...
  61. Cellular Determinants of Coxsackievirus Myocarditis
    Paul Krogstad; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Group B coxsackieviruses (CVB) are a leading cause of infectious myocarditis. Although the replication of enteroviruses is generally well understood, our understanding of CVB pathogenesis is ..
  62. AIDS ASSOCIATED CARDIOMYOPATHY
    AHVIE HERSHKOWITZ; Fiscal Year: 1993
    ..A high prevalence of myocarditis has also been described...
  63. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  64. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    b>Myocarditis is an inflammation of the heart which usually follows microbial infections. Men are more likely to develop myocarditis than women...