left ventricular hypertrophy

Summary

Summary: Enlargement of the left ventricle of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.

Top Publications

  1. ncbi The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association
    Coral Hanevold
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 3795, USA
    Pediatrics 113:328-33. 2004
  2. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
  3. ncbi Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression
    Carmine Zoccali
    Institute of Biomedicine Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy
    Kidney Int 65:1492-8. 2004
  4. ncbi Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: follow-up of an interventional study
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    J Am Soc Nephrol 12:2759-67. 2001
  5. ncbi Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy
    Cordelia J Barrick
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Heart Circ Physiol 292:H2119-30. 2007
  6. pmc Diagnostic and prognostic utility of electrocardiography for left ventricular hypertrophy defined by magnetic resonance imaging in relationship to ethnicity: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Aditya Jain
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am Heart J 159:652-8. 2010
  7. ncbi Left ventricular hypertrophy and geometry in hypertensive patients with chronic kidney disease
    Emilio Nardi
    Dipartimento di Medicina Interna, Cattedra di Medicina Interna and Hypertension Excellence Centre of the European Society of Hypertension, Universita degli Studi di Palermo, Palermo, Italy
    J Hypertens 27:633-41. 2009
  8. ncbi Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy
    Lars Rothermund
    Institut fur Klinische Pharmakologie und Toxikologie, Berlin, Germany
    Am J Hypertens 15:644-52. 2002
  9. pmc Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin bindin
    J R Ortlepp
    Medical Clinic I, Department of Cardiology, University Hospital of Aachen, Aachen, Germany
    Heart 87:270-5. 2002
  10. ncbi Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study
    Martin K Rutter
    Framingham Heart Study, Burlington, Mass, USA
    Circulation 107:448-54. 2003

Detail Information

Publications362 found, 100 shown here

  1. ncbi The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association
    Coral Hanevold
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 3795, USA
    Pediatrics 113:328-33. 2004
    To determine the prevalence of left ventricular hypertrophy (LVH) in a multiethnic group of children and adolescents with hypertension.
  2. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..b>Left ventricular hypertrophy and coronary artery calcification are potent risk factors for mortality in CKD, and FGFs have been ..
  3. ncbi Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression
    Carmine Zoccali
    Institute of Biomedicine Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy
    Kidney Int 65:1492-8. 2004
    Regression of left ventricular hypertrophy (LVH) in the setting of a well-planned intervention study has been associated with longer survival in hemodialysis patients...
  4. ncbi Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: follow-up of an interventional study
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    J Am Soc Nephrol 12:2759-67. 2001
    ..72 (95% confidence interval, 0.51 to 0.90) for mortality due to CV disease. These results show that a partial LVH regression in patients with ESRD had a favorable and independent effect on patients' all-cause and CV survival...
  5. ncbi Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy
    Cordelia J Barrick
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Heart Circ Physiol 292:H2119-30. 2007
    b>Left ventricular hypertrophy (LVH), a risk factor for cardiovascular morbidity and mortality, is commonly caused by essential hypertension...
  6. pmc Diagnostic and prognostic utility of electrocardiography for left ventricular hypertrophy defined by magnetic resonance imaging in relationship to ethnicity: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Aditya Jain
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am Heart J 159:652-8. 2010
    ..Ethnicity is believed to affect electrocardiographic (ECG) performance. We evaluated the diagnostic and prognostic performance of ECG for left ventricular hypertrophy (LVH) as defined by MRI in relationship to ethnicity.
  7. ncbi Left ventricular hypertrophy and geometry in hypertensive patients with chronic kidney disease
    Emilio Nardi
    Dipartimento di Medicina Interna, Cattedra di Medicina Interna and Hypertension Excellence Centre of the European Society of Hypertension, Universita degli Studi di Palermo, Palermo, Italy
    J Hypertens 27:633-41. 2009
    To evaluate the prevalence of left ventricular hypertrophy (LVH) and left ventricular geometry in a group of 293 hypertensive patients with stage 2-5 chronic kidney disease (CKD), compared with 289 essential hypertensive patients with ..
  8. ncbi Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy
    Lars Rothermund
    Institut fur Klinische Pharmakologie und Toxikologie, Berlin, Germany
    Am J Hypertens 15:644-52. 2002
    ..The objective of this study was to analyze extracellular matrix protein (ECMP) expression in Ang II-dependent left ventricular (LV) hypertrophy (LVH), LV dysfunction, and to investigate right ventricular changes...
  9. pmc Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin bindin
    J R Ortlepp
    Medical Clinic I, Department of Cardiology, University Hospital of Aachen, Aachen, Germany
    Heart 87:270-5. 2002
    ..Phenotypic expression is heterogeneous even within families with the same aetiological mutation and may be influenced by additional genetic factors...
  10. ncbi Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study
    Martin K Rutter
    Framingham Heart Study, Burlington, Mass, USA
    Circulation 107:448-54. 2003
    ..Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias...
  11. ncbi Impact of valve prosthesis-patient mismatch on left ventricular mass regression following aortic valve replacement
    Giordano Tasca
    Department of Cardiac Surgery, Poliambulanza Hospital, Brescia, Italy
    Ann Thorac Surg 79:505-10. 2005
    ..The persistence of high gradients may hinder or delay the regression of left ventricular hypertrophy after aortic valve replacement.
  12. ncbi Effect of sirolimus on left ventricular hypertrophy in kidney transplant recipients: a 1-year nonrandomized controlled trial
    Ernesto Paoletti
    Divisione di Nefrologia, Dialisi, e Trapianto, Azienda Ospedaliera Universitaria S Martino, Genova, Italy
    Am J Kidney Dis 52:324-30. 2008
    b>Left ventricular hypertrophy (LVH) after renal transplantation may be affected by immunosuppressive therapy.
  13. ncbi Prognostic significance of left ventricular mass change during treatment of hypertension
    Richard B Devereux
    Department of Medicine, New York Presbyterian Hospital, Cornell Medical Center, New York, NY 10021, USA
    JAMA 292:2350-6. 2004
    ..Increased baseline left ventricular (LV) mass predicts cardiovascular (CV) complications of hypertension, but the relation between lower LV mass and outcome during treatment for hypertension is uncertain...
  14. ncbi Methylene tetrahydrofolate reductase C677T mutation and left ventricular hypertrophy in Turkish patients with type II diabetes mellitus
    Hulya Yilmaz
    Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey
    J Biochem Mol Biol 37:234-8. 2004
    ..population, the association of methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and left ventricular hypertrophy (LVH) in patients with type II diabetes mellitus...
  15. ncbi Association between biomarkers of inflammation and left ventricular hypertrophy in moderate chronic kidney disease
    S Cottone
    Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Divisione di Medicina Interna, Nefrologia ed Ipertensione ed Unità Operativa semplice di Malattie Renali ed Ipertensione, Universita di Palermo, Italy
    Clin Nephrol 67:209-16. 2007
    b>Left ventricular hypertrophy (LVH) is a predictor for cardiovascular mortality, and it is considered to be a surrogate marker of preclinical cardiovascular disease...
  16. ncbi Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events
    Peter M Okin
    Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY 10021, USA
    JAMA 292:2343-9. 2004
    Electrocardiographic left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular (CV) morbidity and mortality...
  17. ncbi Regression of pressure overload-induced left ventricular hypertrophy in mice
    Xiao Ming Gao
    Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Am J Physiol Heart Circ Physiol 288:H2702-7. 2005
    ..In conclusion, LVH regression comprises a variety of morphological, functional, and genetic components that show distinct time courses. A longer period of pressure overload is associated with a slower rate of LVH regression...
  18. pmc Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review
    Daniel Pewsner
    Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, CH 3012 Berne, Switzerland
    BMJ 335:711. 2007
    To review the accuracy of electrocardiography in screening for left ventricular hypertrophy in patients with hypertension.
  19. ncbi Gender-related association of serum uric acid and left ventricular hypertrophy in hypertension
    Kiyoshi Matsumura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ J 70:885-8. 2006
    The aim of the present study was to determine whether sex differences contribute to the association of serum uric acid and left ventricular hypertrophy in individuals with hypertension.
  20. ncbi Prevalence of left ventricular hypertrophy in hypertensive patients without and with blood pressure control: data from the PAMELA population. Pressioni Arteriose Monitorate E Loro Associazioni
    Giuseppe Mancia
    Clinica Medica e Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie, Universita Milano Bicocca, Ospedale San Gerardo, Monza Milano, Italy
    Hypertension 39:744-9. 2002
    ..the normotensive group, left ventricular mass index, left ventricular wall thickness, and prevalence of left ventricular hypertrophy were markedly increased not only in untreated hypertensive patients but also in treated hypertensives ..
  21. ncbi A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension
    Arnfried U Klingbeil
    Department of Medicine IV, University of Erlangen Nurnberg, Nuremberg, Germany
    Am J Med 115:41-6. 2003
    ..Antihypertensive medications have different effects on left ventricular mass. We conducted a meta-analysis of double-blind trials that measured the effects of antihypertensive therapy on left ventricular mass...
  22. ncbi Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO* and beyond
    Rebecca H Ritchie
    Heart Failure Pharmacology, Baker IDI Heart and Diabetes Institute Melbourne, Victoria, Australia
    Pharmacol Ther 124:279-300. 2009
    b>Left ventricular hypertrophy (LVH), an increased left ventricular (LV) mass, is common to many cardiovascular disorders, initially developing as an adaptive response to maintain myocardial function...
  23. ncbi Reverse correlation between ankle-brachial index and left ventricular hypertrophy in patients on maintenance haemodialysis
    Wencheng Fu
    Department of Nephrology, Center of Kidney Disease, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Nephrology (Carlton) 11:9-14. 2006
    b>Left ventricular hypertrophy (LVH) and peripheral vascular disease (PVD) are highly prevalent among patients undergoing maintenance haemodialysis (MHD) and contribute to most cardiovascular mortalities in this population...
  24. ncbi Left ventricular hypertrophy and abnormal ventricular geometry in children and adolescents with obstructive sleep apnea
    Raouf S Amin
    Department of Pulmonary Medicine, Allergy and Clinical Immunology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Respir Crit Care Med 165:1395-9. 2002
    ..2; confidence interval, 1.9-64). Abnormality of LV geometry was present in 15% of children with PS compared with 39% of children with OSA. We conclude that OSA in children is associated with increased LV mass...
  25. pmc Delayed hyperenhancement in magnetic resonance imaging of left ventricular hypertrophy caused by aortic stenosis and hypertrophic cardiomyopathy: visualisation of focal fibrosis
    K Debl
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat, Regensburg, Germany
    Heart 92:1447-51. 2006
    ....
  26. ncbi Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension
    S Ichihara
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Circulation 104:346-51. 2001
    ..In the present study, we examined the hypothesis that signaling by AT(2) is important to the development of left ventricular hypertrophy and cardiac fibrosis by Ang II infusion in mice lacking the AT(2) gene (Agtr2-/Y).
  27. ncbi Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Cornell Medical College, New York 10021, USA
    J Hypertens 28:384-8. 2010
    ..Data regarding the relative impacts of central and brachial pressures on left ventricular hypertrophy and geometry are limited.
  28. ncbi Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: a randomized controlled trial
    Bruce F Culleton
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 298:1291-9. 2007
    ..Morbidity and mortality rates in hemodialysis patients remain excessive. Alterations in the delivery of dialysis may lead to improved patient outcomes...
  29. ncbi Effects of short daily versus conventional hemodialysis on left ventricular hypertrophy and inflammatory markers: a prospective, controlled study
    Juan Carlos Ayus
    Division of Nephrology, Texas Diabetes Institute, University of Texas Health Science Center San Antonio, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 16:2778-88. 2005
    b>Left ventricular hypertrophy (LVH) and inflammation independently increase risk for death in people who receive hemodialysis...
  30. ncbi Upregulating the heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months
    Joseph Fomusi Ndisang
    Department of Physiology, University of Saskatchewan College of Medicine, Saskatoon, SK, Canada
    J Card Fail 15:616-28. 2009
    ..The multifaceted interaction between HO-1 and aldosterone-PLC profibrotic axis in cardiac hypertrophy of spontaneously hypertensive rats (SHR) was studied...
  31. ncbi Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients
    Heng Jung Hsu
    School of Medicine, Chang Gung University, and Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan
    Am J Med Sci 337:116-22. 2009
    b>Left ventricular hypertrophy (LVH) is a common cardiovascular disorder and an independent risk factor for cardiovascular death in dialysis patients. Hyperphosphatemia is associated with LVH...
  32. ncbi Left ventricular concentric geometry during treatment adversely affects cardiovascular prognosis in hypertensive patients
    Maria Lorenza Muiesan
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Hypertension 43:731-8. 2004
    ..001 in the third tertile; P<0.0001 in concentric versus eccentric geometry). Persistence or development of concentric geometry during follow-up may have additional prognostic significance in hypertensive patients with and without LVH...
  33. ncbi Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression
    Daniela Sorriento
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
    Hypertension 56:696-704. 2010
    ..In conclusion, our study supports the regulation of LVH based on the GRK5-NT inhibition of the NF-κB transduction signaling...
  34. ncbi Left ventricular hypertrophy and arterial wall thickening in children with essential hypertension
    Mieczysław Litwin
    Department of Nephrology, Division of Nephrology and Arterial Hypertension, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Pediatr Nephrol 21:811-9. 2006
    Our aim was to determine the prevalence of left ventricular hypertrophy (LVH) and increased intima-media thickness (IMT) in Caucasian children with newly diagnosed, untreated essential hypertension (EH).
  35. pmc Echocardiography-based left ventricular mass estimation. How should we define hypertrophy?
    Murilo Foppa
    Graduate Studies Program in Cardiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre RS, Brazil
    Cardiovasc Ultrasound 3:17. 2005
    b>Left ventricular hypertrophy is an important risk factor in cardiovascular disease and echocardiography has been widely used for diagnosis...
  36. ncbi Genetic polymorphisms and heart failure
    Gysèle S Bleumink
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Genet Med 6:465-74. 2004
    ..Research on left ventricular hypertrophy is also included. The majority of genetic association studies focused on the ACE I/D polymorphism...
  37. ncbi Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study)
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Cardiol 93:40-4. 2004
    ..Therefore, abnormal LV geometry and function are related to the MS. Increased BP is the component of the MS most strongly associated with cardiac markers of preclinical disease, even in the absence of traditionally defined hypertension...
  38. ncbi Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy
    Frank Grothues
    Centre for Advanced MR in Cardiology, Cardiovascular MR Unit, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London, United Kingdom
    Am J Cardiol 90:29-34. 2002
    ..Thus, CMR has excellent interstudy reproducibility in normal, dilated, and hypertrophic hearts, and is superior to 2-dimensional echocardiography...
  39. ncbi Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy
    Justin E Davies
    International Centre for Circulatory Health, St Mary s Hospital, Imperial College, Paddington, London W2 1LA, UK
    Circulation 113:1768-78. 2006
    ..Current models fail to completely explain this phenomenon. We present a new approach-using wave intensity analysis-to explain this phenomenon in normal subjects and to evaluate the effects of left ventricular hypertrophy (LVH).
  40. pmc AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice
    Ping Zhang
    Cardiovascular Division, University of Minnesota, Minneapolis, MN 55455, USA
    Hypertension 52:918-24. 2008
    ..These data indicate that AMPKalpha2 exerts a cardiac protective effect against pressure-overload-induced ventricular hypertrophy and dysfunction...
  41. ncbi Long-term CAPD patients are volume expanded and display more severe left ventricular hypertrophy than haemodialysis patients
    G Enia
    Centro di Fisiologia Clinica del CNR e Divisione di Nefrologia, Reggio Calabria, Italy
    Nephrol Dial Transplant 16:1459-64. 2001
    BACKGROUND: Whether hypertension and left ventricular hypertrophy (LVH) are more prevalent in CAPD than in haemodialysis (HD) patients is still under discussion...
  42. ncbi Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Hypertens 20:323-31. 2002
    ..To determine whether combinations of metabolic risk factors (obesity, diabetes and hypercholesterolemia) influence the magnitude of left ventricular (LV) mass and prevalence of LV hypertrophy...
  43. ncbi Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation
    Yukiko Abe
    Department of Cardiovascular Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto, 606 8507, Japan
    Am J Physiol Heart Circ Physiol 292:H2387-96. 2007
    ..13 +/- 0.09 mm). These results demonstrate that leptin induces the elongation of cardiac myocytes via a JAK/STAT pathway and chronic leptin infusion causes eccentric dilatation with augmented systolic function after myocardial infarction...
  44. pmc Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction
    Zhongbing Lu
    Center for Vascular Biology, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hypertension 51:19-25. 2008
    ..In response to TAC for 6 weeks, extracellular SOD-deficient mice developed more severe left ventricular hypertrophy (heart weight increased 2.56-fold in extracellular SOD-deficient mice as compared with 1...
  45. ncbi Gender differences in electrical remodeling and susceptibility to ventricular arrhythmias in rabbits with left ventricular hypertrophy
    Marcelo O Biagetti
    Cardiac Electrophysiology Laboratory, Physiology Department, Favaloro University, Buenos Aires, Argentina
    Heart Rhythm 3:832-9. 2006
    b>Left ventricular hypertrophy (LVH) is associated with an increased risk of death, vulnerability to ventricular arrhythmia, and multiple electrophysiological abnormalities.
  46. ncbi A novel association between residual renal function and left ventricular hypertrophy in peritoneal dialysis patients
    Angela Yee Moon Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, China
    Kidney Int 62:639-47. 2002
    b>Left ventricular hypertrophy (LVH) and dialysis adequacy are both important predictors for mortality in dialysis patients...
  47. ncbi Prevalence and determinants of electrocardiographic left ventricular hypertrophy among a multiethnic population of postmenopausal women (The Women's Health Initiative)
    Albert Oberman
    Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham School of Medicine, USA
    Am J Cardiol 97:512-9. 2006
    Our objectives were to determine the prevalence and factors related to left ventricular hypertrophy (LVH) among older women for commonly used electrocardiographic criteria...
  48. ncbi Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy
    Andreas Kjaer
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet University Hospital, Copenhagen, Denmark
    Am J Cardiol 96:1692-8. 2005
    Myocardial perfusion (MP) may differ in physiologic and pathologic left ventricular hypertrophy (LVH). We compared MP in LVH in elite athletes and patients with hypertension with healthy, age-matched subjects...
  49. ncbi Differentiation between pathologic and physiologic left ventricular hypertrophy by tissue Doppler assessment of long-axis function in patients with hypertrophic cardiomyopathy or systemic hypertension and in athletes
    D Vinereanu
    Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Cardiol 88:53-8. 2001
    ..These simple new echocardiographic parameters can differentiate between pathologic and physiologic hypertrophy...
  50. ncbi Left ventricular hypertrophy is more prevalent in blacks than whites in the general population: the Dallas Heart Study
    Mark H Drazner
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Hypertension 46:124-9. 2005
    Although recent studies have suggested that blacks compared with whites have an increased prevalence of left ventricular hypertrophy, it remains uncertain whether this is true despite adjustment for body composition (fat mass and fat-free ..
  51. ncbi Changes in left ventricular mass index in children and adolescents after renal transplantation
    M M Mitsnefes
    Division of Nephrology and Hypertension, Department of Pediatrics, University of Cincinnati College of Medicine, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Pediatr Transplant 5:279-84. 2001
    Recent reports indicate a high prevalence of left ventricular hypertrophy (LVH) in children on dialysis and after renal transplantation (Tx), as identified by cross-sectional analysis...
  52. ncbi Regression of left ventricular hypertrophy after conversion to nocturnal hemodialysis
    Christopher T Chan
    Division of Nephrology, Department of Medicine, The Toronto General Hospital, University Health Network, Ontario, Canada
    Kidney Int 61:2235-9. 2002
    b>Left ventricular hypertrophy (LVH) is an independent risk factor for mortality in the dialysis population. LVH has been attributed to several factors, including hypertension, excess extracellular fluid (ECF) volume, anemia and uremia...
  53. ncbi Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure?
    Markku Kupari
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, 00029 Helsinki, Finland
    Eur Heart J 26:1790-6. 2005
    ..The present work aimed to clarify the role of LV hypertrophy in AS-related heart failure (HF) in man...
  54. ncbi Adverse prognostic significance of new diabetes in treated hypertensive subjects
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
    Hypertension 43:963-9. 2004
    ..In treated hypertensive subjects, occurrence of new diabetes portends a risk for subsequent cardiovascular disease that is not dissimilar from that of previously known diabetes...
  55. ncbi Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling
    Andre Rudolph
    Franz Volhard Klinik, Charite Campus Buch, HELIOS Kliniken Berlin, Universitatsmedizin Berlin, Berlin, Germany
    J Am Coll Cardiol 53:284-91. 2009
    We aimed to evaluate the incidence and patterns of late gadolinium enhancement (LGE) in different forms of left ventricular hypertrophy (LVH) and to determine their relation to severity of left ventricular (LV) remodeling.
  56. ncbi Plasma adiponectin levels are associated with left ventricular hypertrophy in a random sample of middle-aged subjects
    Tero Pääkkö
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Ann Med 42:131-7. 2010
    A low adiponectin level is associated with high blood pressure which, in turn, often results in left ventricular hypertrophy. We evaluated the association between plasma adiponectin concentrations and echocardiographic measurements, ..
  57. ncbi Development, prevention, and potential reversal of left ventricular hypertrophy in chronic kidney disease
    Lawrence P McMahon
    Department of Nephrology, Western and Royal Melbourne Hospitals, Melbourne, Victoria 3050, Australia
    J Am Soc Nephrol 15:1640-7. 2004
    ....
  58. ncbi Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1
    Anne Lumiaho
    Department of Medicine, Kuopio University Hospital Kuopio, Finland
    Am J Kidney Dis 41:1219-24. 2003
    b>Left ventricular hypertrophy (LVH) is common in patients with autosomal dominant polycystic kidney disease (ADPKD)...
  59. ncbi High prevalence of the metabolic syndrome and associated left ventricular hypertrophy in pediatric renal transplant recipients
    Amy C Wilson
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Pediatr Transplant 14:52-60. 2010
    ..A total of patients from four centers had routine echocardiogram at one-yr post-transplant. LVH was significantly more common in those with metabolic syndrome (55%) than in those without (32%) (OR 2.6, 95% CI 1.2-5.9)...
  60. ncbi Correlates of left atrial size in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
    Eva Gerdts
    Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
    Hypertension 39:739-43. 2002
    b>Left ventricular hypertrophy has been suggested to mediate the relation between hypertension and left atrial enlargement, with associated risks of atrial fibrillation and stroke...
  61. ncbi Discrepancy between increased left ventricular mass and "normal" QRS voltage is associated with decreased connexin 43 expression in early stage of left ventricular hypertrophy in spontaneously hypertensive rats
    Ljuba Bacharova
    International Laser Center, Bratislava, Slovak Republic
    J Electrocardiol 41:730-4. 2008
    ..ventricular mass (LVM) and electrocardiographic (ECG) findings not exceeding the upper normal limits in left ventricular hypertrophy (LVH) are conditioned by the electrical remodeling of hypertrophied myocardium...
  62. pmc Progressive regression of left ventricular hypertrophy two years after bariatric surgery
    Mohamed F Algahim
    Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am J Med 123:549-55. 2010
    ..We hypothesized that the decrease in fat mass and lean mass after weight loss surgery is associated with a decrease in left ventricular mass...
  63. ncbi The impact of different echocardiographic diagnostic criteria on the prevalence of left ventricular hypertrophy in essential hypertension: the VITAE study. Ventriculo Izquierdo Tension Arterial España
    A Coca
    Hypertension Unit, Hospital Clinic, University of Barcelona, Spain
    J Hypertens 17:1471-80. 1999
    The prevalence of echocardiographic left ventricular hypertrophy in essential hypertension ranges from 12 to 96% depending on the threshold values used to define it, and on the selection bias.
  64. ncbi The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension
    Xiaojian Wang
    Sino German Laboratory for Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics of Ministry of Education, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Clin Sci (Lond) 118:137-45. 2010
    ..In the present study, we have investigated the relationship between GDF15 gene variants and left ventricular hypertrophy in human essential hypertension...
  65. pmc Association of left atrial volume with mortality among ESRD patients with left ventricular hypertrophy referred for kidney transplantation
    Rajan K Patel
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK
    Am J Kidney Dis 55:1088-96. 2010
    b>Left ventricular hypertrophy (LVH) is common in patients with end-stage renal disease (ESRD) and an independent risk factor for premature cardiovascular death...
  66. ncbi The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model
    Moto o Date
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Am Coll Cardiol 39:907-12. 2002
    ..In order to identify the role of reactive oxygen species (ROS) in cardiac hypertrophy, we examined the effect of N-2-mercaptopropionyl glycine (MPG) on cardiac hypertrophy...
  67. pmc Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy
    Naveen Sharma
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Cardiovasc Res 73:257-68. 2007
    ..composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized...
  68. ncbi Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure
    Takao Kato
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ Heart Fail 3:420-30. 2010
    ..Congestive heart failure (CHF) is associated with a change in cardiac energy metabolism. However, the mechanism by which this change is induced and causes the progression of CHF is unclear...
  69. ncbi Angiotensin II type 1 receptor antagonist, losartan, causes regression of left ventricular hypertrophy in end-stage renal disease
    Yasunoba Shibasaki
    Department of Medicine II, Kansai Medical University, Moriguchi, Osaka, Japan
    Nephron 90:256-61. 2002
    b>Left ventricular hypertrophy (LVH) commonly occurs in patients with end-stage renal disease (ESRD) and is an independent risk factor for cardiovascular events...
  70. ncbi Obesity and daytime pulse pressure are predictors of left ventricular hypertrophy in true normotensive individuals
    Vasilios Kotsis
    Hypertension Center, Third Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
    J Hypertens 28:1065-73. 2010
    To investigate predictors of left ventricular mass corrected for height2.7 (LVMI) and left ventricular hypertrophy in patients who were found to be normotensive with both office and 24-h ambulatory blood pressure (BP) measurements.
  71. ncbi Left ventricular hypertrophy: an overlooked cardiovascular risk factor
    Michael A Bauml
    Department of Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cleve Clin J Med 77:381-7. 2010
    b>Left ventricular hypertrophy (LVH) is common in hypertensive patients, and it increases the risk of myocardial infarction, stroke, and death...
  72. ncbi Angiotensin receptor antagonist regresses left ventricular hypertrophy associated with diabetic nephropathy in dialysis patients
    Yoshihiko Kanno
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    J Cardiovasc Pharmacol 43:380-6. 2004
    b>Left ventricular hypertrophy (LVH) is frequently found at the initiation of dialysis therapy for diabetic and hypertensive patients, and is highly predictive of future cardiac morbidity and mortality...
  73. ncbi Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly men
    J Sundstrom
    Departments of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Circulation 103:2346-51. 2001
    The increased risk associated with left ventricular hypertrophy (LVH) diagnosed echocardiographically (Echo-LVH) or electrocardiographically (ECG-LVH) is well known, but the clinically relevant question of how much additional prognostic ..
  74. ncbi Studies on left ventricular hypertrophy regression in arterial hypertension: a clear message for the clinician?
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    Am J Hypertens 21:458-63. 2008
    ....
  75. pmc Performance of electrocardiographic criteria for left ventricular hypertrophy as compared with cardiac computed tomography: from the Rule Out Myocardial Infarction Using Computer Assisted Tomography trial
    Quynh A Truong
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Hypertens 28:1959-67. 2010
    ..that provides an accurate noninvasive method to quantify left ventricular mass for analysis of left ventricular hypertrophy (LVH)...
  76. ncbi Left ventricular hypertrophy: the next treatable, silent killer?
    Julius M Gardin
    JAMA 292:2396-8. 2004
  77. pmc Marked regional left ventricular heterogeneity in hypertensive left ventricular hypertrophy patients: a losartan intervention for endpoint reduction in hypertension (LIFE) cardiovascular magnetic resonance and echocardiographic substudy
    Robert W W Biederman
    Division of Cardiology, Department of Cardiovascular MRI, Gerald McGuiness Center, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
    Hypertension 52:279-86. 2008
    ....
  78. ncbi Effects of papillary muscles and trabeculae on left ventricular quantification: increased impact of methodological variability in patients with left ventricular hypertrophy
    Matthew Janik
    Greenberg Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York 10021, USA
    J Hypertens 26:1677-85. 2008
    Accurate quantification of left ventricular mass and ejection fraction is important for patients with left ventricular hypertrophy. Although cardiac magnetic resonance imaging has been proposed as a standard for these indices, prior ..
  79. ncbi Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings
    Jiang Deng
    Department of Pharmacology, Zunyi Medical College, Zunyi, Guizhou, PR China
    Eur J Pharmacol 608:42-7. 2009
    ..This study aims to investigate whether Rg(1) has protective effect on rat left ventricular hypertrophy and to probe its protective mechanisms...
  80. ncbi Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats
    Danelle Badenhorst
    Cardiovascular Pathophysiology Research Unit, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa
    Cardiovasc Res 57:632-41. 2003
    ....
  81. ncbi Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension
    Guido Iaccarino
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II di Napoli, Italy
    Clin Pharmacol Ther 80:633-45. 2006
    Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication...
  82. ncbi Left ventricular hypertrophy in nondiabetic predialysis CKD
    Ernesto Paoletti
    Divisionse di Nefrologia, Dialisi e Trapianto and Cardiologia, Azienda Ospedaliera Universitaria S Martino, Genova, Italy
    Am J Kidney Dis 46:320-7. 2005
    Although left ventricular hypertrophy (LVH) is a strong predictor of mortality in patients with end-stage renal disease, few studies are available before the start of dialysis treatment...
  83. pmc Accuracy of advanced versus strictly conventional 12-lead ECG for detection and screening of coronary artery disease, left ventricular hypertrophy and left ventricular systolic dysfunction
    Todd T Schlegel
    Human Adaptation and Countermeasures Division, NASA Johnson Space Center, Houston, TX, USA
    BMC Cardiovasc Disord 10:28. 2010
    Resting conventional 12-lead ECG has low sensitivity for detection of coronary artery disease (CAD) and left ventricular hypertrophy (LVH) and low positive predictive value (PPV) for prediction of left ventricular systolic dysfunction (..
  84. ncbi Regression of left ventricular hypertrophy after arteriovenous fistula closure in renal transplant recipients: a long-term follow-up
    Philippe Unger
    Department of Cardiology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Transplant 4:2038-44. 2004
    ..However, residual concentric remodeling geometry as well as diastolic blood pressure increase may blunt the expected beneficial cardiac effects of the procedure...
  85. ncbi Role of nitric oxide in ginsenoside Rg(1)-induced protection against left ventricular hypertrophy produced by abdominal aorta coarctation in rats
    Jiang Deng
    Department of Pharmacology, Zunyi Medical College, China
    Biol Pharm Bull 33:631-5. 2010
    ..These results demonstrate that Rg(1)-induced protection against LV hypertrophy elicited by abdominal aorta coarctation in rats is mediated, at least in part, via endogenous NO production and release...
  86. ncbi Prognostic impact of the indexation of left ventricular mass in patients undergoing dialysis
    C Zoccali
    Centre of Clinical Physiology and Division of Nephrology, Morelli Hospital, Reggio Cal, Italy
    J Am Soc Nephrol 12:2768-74. 2001
    b>Left ventricular hypertrophy (LVH) is exceedingly frequent in patients undergoing dialysis...
  87. ncbi Different normalizations for body size and population attributable risk of left ventricular hypertrophy: the MAVI study
    Giovanni de Simone
    Department of Clinical and Experimental Medicine, Federico II University Hospital, School of Medicine, Naples, Italy
    Am J Hypertens 18:1288-93. 2005
    ..Preliminary results from a population with high prevalence of obesity suggest that the population attributable-risk percent (PAR%) of LVH is substantially higher when LV mass is normalized for allometric power of height...
  88. ncbi Patterns of left ventricular hypertrophy in essential hypertension: should echocardiography guide the pharmacological treatment?
    Diego F Davila
    Instituto de Investigaciones Cardiovasculares Universidad de Los Andes Mérida, Venezuela
    Int J Cardiol 124:134-8. 2008
    ..These facts raise a relevant question: Should ventricular geometry be considered when deciding which antihypertensive drug is to be prescribed?..
  89. ncbi Influence of low high-density lipoprotein cholesterol on left ventricular hypertrophy and diastolic function in essential hypertension
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Hypertens 16:938-44. 2003
    ..Although low high-density lipoprotein (HDL) cholesterol is well known to be a major risk factor for coronary heart disease, it is unclear whether HDL cholesterol plays a role in hypertensive heart disease...
  90. ncbi Role of aldosterone in left ventricular hypertrophy in hypertension
    Kiyoshi Matsumura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Am J Hypertens 19:13-8. 2006
    ..The aim of the present study was to determine the role of aldosterone in LV geometry and to investigate other types of target organ damage in hypertensive patients...
  91. pmc Prevalence and covariates of electrocardiographic left ventricular hypertrophy in diabetic patients in Tanzania
    J J K Lutale
    Institute of Medicine and Centre for International Health, University of Bergen, Bergen, Norway
    Cardiovasc J Afr 19:8-14. 2008
    b>Left ventricular hypertrophy (LVH) has been demonstrated to be a powerful predictor of cardiovascular (CV) morbidity and mortality in diabetic as well as hypertensive patients...
  92. ncbi Left ventricular hypertrophy and renin-angiotensin system blockade
    Brett R Cowan
    Centre for Advanced MRI, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1142, New Zealand
    Curr Hypertens Rep 11:167-72. 2009
    ..system (RAS), an important control system for blood pressure and intravascular volume, also causes left ventricular hypertrophy (LVH) and fibrosis...
  93. ncbi Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: the Cardiovascular Health Study
    Mark H Drazner
    Heart Failure Research Unit, Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Coll Cardiol 43:2207-15. 2004
    ..Our aim in this study was to determine whether increased left ventricular mass (LVM) is a risk factor for the development of a reduced left ventricular ejection fraction (LVEF)...
  94. ncbi A systematic review of the effect of nocturnal hemodialysis on blood pressure, left ventricular hypertrophy, anemia, mineral metabolism, and health-related quality of life
    Michael Walsh
    Department of Medicine, University of Calgary, Alberta, Canada
    Kidney Int 67:1500-8. 2005
    ..A systematic review of the current available literature was undertaken to examine the effect of nocturnal hemodialysis on key health outcomes...
  95. ncbi Associations of insulin levels with left ventricular structure and function in American Indians: the strong heart study
    Arzu Ilercil
    Montefiore Medical Center of the Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 51:1543-7. 2002
    ....
  96. ncbi Sex-differences in prevalence of electrocardiographic left ventricular hypertrophy in Type 2 diabetes: the Casale Monferrato Study
    G Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabet Med 21:823-8. 2004
    AIMS Although left ventricular hypertrophy (LVH) defined by either standard 12-lead ECG or echocardiography strongly predicts cardiovascular mortality, its prevalence in Type 2 diabetes is largely unknown...
  97. ncbi Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension: the prospective randomized enalapril study evaluat
    R B Devereux
    Cornell Medical Center, New York, NY, 10021, USA
    Circulation 104:1248-54. 2001
    ....
  98. ncbi Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study
    Benedicte P Wiik
    Department of Cardiology, Oslo University Hospital, Norway
    Am J Hypertens 23:845-51. 2010
    ..acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH)...
  99. ncbi Association between wasted pressure effort and left ventricular hypertrophy in hypertension: influence of arterial wave reflection
    Junichiro Hashimoto
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Am J Hypertens 21:329-33. 2008
    ..The purpose of this study was to extract that component of extra myocardial oxygen requirement that is due to early systolic wave reflection, define it as wasted effort (DeltaE(w)), and examine its relationship to LV hypertrophy (LVH)...
  100. ncbi From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease
    Alan H Gradman
    Western Pennsylvania Hospital, Pittsburgh, PA 15224, USA
    Prog Cardiovasc Dis 48:326-41. 2006
    Other than age, left ventricular hypertrophy (LVH) is the most potent predictor of adverse cardiovascular outcomes in the hypertensive population, and is an independent risk factor for coronary heart disease, sudden death, heart failure ..
  101. ncbi Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans
    M A Rossi
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Hypertens 16:1031-41. 1998
    To investigate pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans.

Research Grants70

  1. Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis
    Steven M Kawut; Fiscal Year: 2010
    ..While the importance of systemic hypertension and subsequent left ventricular hypertrophy is quite well-defined, our understanding of the effects of pulmonary hypertension on the RV is ..
  2. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013
    ..and secondary hyperparathyroidism, increased bone remodeling and bone loss, arterial calcification, and left ventricular hypertrophy, accurately reflecting the clinical disease progression observed in humans with CKD...
  3. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..hyperglycemia in wild type (WT) mice caused a loss of cardiac progenitor cells and the development of left ventricular hypertrophy. Hyperglycemia-induced cardiac abnormalities in this acute hyperglycemia model were completely reversed ..
  4. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..Further, acute hyperglycemia in wild type (WT) mice demonstrated loss of cardiac progenitor cells and left ventricular hypertrophy. Hyperglycemia- induced cardiac abnormalities in this acute hyperglycemia model were completely ..
  5. ETS-1 and Vascular and Renal Injury in Salt Sensitive Hypertension
    Edgar A Jaimes; Fiscal Year: 2013
    ..is associated with an increased risk for the development of end-organ injury including atherosclerosis, left ventricular hypertrophy and renal disease...
  6. Endogenous Cardiac Glycosides in AASK
    Brad C Astor; Fiscal Year: 2010
    ..is partially explained by an elevated prevalence of several CVD risk factors, including hypertension, left ventricular hypertrophy (LVH) and heart failure, which increase in prevalence and severity as kidney function declines...
  7. Using a MALDI-TOF System for SNP Analysis
    Nadereh Jafari; Fiscal Year: 2010
    ..Sclerosis, e) investigate the genetic and structural determinants of heart failure and left ventricular hypertrophy, f)rapidly genotype the Y-chromosome and autosomal SNPs to assess the nature of the evolutionary ..
  8. A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney Disease
    Joachim H Ix; Fiscal Year: 2013
    ..Higher serum Pi induces arterial calcification, arterial stiffness, and left ventricular hypertrophy in animals...
  9. RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
    Robert Schneider; Fiscal Year: 2010
    ..stress, insulin resistance-metabolic syndrome, myocardial ischemia, carotid atherosclerosis, left ventricular hypertrophy, and mortality rates...
  10. Reduced contractile reserve: a therapeutic target in heart failure with normal EF
    Nancy K Sweitzer; Fiscal Year: 2012
    ..patients with shortness of breath due to pulmonary disease, and those with hypertension and left ventricular hypertrophy without clinical heart failure...
  11. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..Clinical characteristics include left ventricular hypertrophy (LVH), myocardial fibrosis, diastolic dysfunction, and an increased risk for arrhythmias, sudden death ..
  12. Attenuation of cardiac parasympathetic nerve acetylcholine release in obesity by
    Wohaib Hasan; Fiscal Year: 2012
    ..provided by applicant): Obesity can lead to several cardiovascular problems including hypertension and left ventricular hypertrophy. In addition, increased heart rate and plasma catecholamines, and reduced heart rate variability in ..
  13. HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
    Stefan Neubauer; Fiscal Year: 2013
    ..It is characterized by unexplained left ventricular hypertrophy (LVH), diffuse and patchy fibrosis, and myofibrillar disarray...
  14. Environmental Toxicants, Race, and Cardiovascular Disease Risk in Children
    Brooks B Gump; Fiscal Year: 2013
    ..Moreover, studies suggest a positive association between Pb and blood pressure, left ventricular hypertrophy, and CVD mortality...
  15. Acuson Sequoia C512 Echocardiography System
    Sandrine V Pierre; Fiscal Year: 2010
    ..of damaged cardiomyoctes, and the role of TRPC3 channels in atherogenesis and the development of left ventricular hypertrophy will also benefit from the availability of the requested imaging system...
  16. Disordered Mineral Metabolism in the CKiD Children: Role of FGF-23
    Anthony A Portale; Fiscal Year: 2013
    ..CKD, before the development of hyperphosphatemia, and the increased FGF-23 levels are associated with left ventricular hypertrophy, coronary artery calcification, and mortality...
  17. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel L Dries; Fiscal Year: 2011
    ....
  18. A Novel Device for Managing Hypervolemia in CHF Patients
    Mohamed E Labib; Fiscal Year: 2011
    ..Aside from the implied benefit of controlling congestive heart failure and potentially reducing left ventricular hypertrophy (LVH), a major cause of morbidity and mortality in dialysis patients, this device would be expected to ..
  19. Mechanisms of Regulation Of NHE-1
    John R Raymond; Fiscal Year: 2012
    ..NHE-1 has also been implicated in clinically relevant conditions such as hypertension, left ventricular hypertrophy, and ischemia-reperfusion injury...
  20. Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies
    Jil C Tardiff; Fiscal Year: 2013
    ..the thin filament proteins is particularly complex, whereby many patients do not develop the "classic" left ventricular hypertrophy, but instead undergo aggressive ventricular remodeling and experience a significant frequency of sudden ..
  21. AGE/RAGE Interaction in Patients with Pressure Overload-Induced Heart Failure
    Michael R Zile; Fiscal Year: 2013
    ..valve stenosis, the myocardium undergoes hypertrophic remodeling that results in the development of left ventricular hypertrophy (LVH)...
  22. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2013
    ..in wild-type mice show that pressure overload induced by transverse aortic constriction (TAC) leads to left ventricular hypertrophy (LVH) and increased IL-18 expression...
  23. Genetics of Hypertension Risk Factors and Sequela in African Americans
    Yan Sun; Fiscal Year: 2010
    ..genome-wide regions containing evidence of disease susceptibility loci for hypertension, obesity, left ventricular hypertrophy, and kidney function, we will perform analyses in each African American populations to identify ..
  24. Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He
    Flora Sam; Fiscal Year: 2013
    ..Recently our lab showed that hypoadiponectinemia in hypertension-induced diastolic HF exacerbates left ventricular hypertrophy, diastolic dysfunction and diastolic HF...
  25. Onset and Progression of Contractile Dysfunction in Hypertrophic Cardiomyopathy
    PETER P CHEN; Fiscal Year: 2012
    ..of hypertrophic cardiomyopathy (HCM), a genetically heterogeneous disease of the heart characterized by left ventricular hypertrophy and impaired contractile function...
  26. ESRD Endocrinopathy and Daily Dialysis
    Joan C Lo; Fiscal Year: 2012
    ..to mineral metabolism and inflammation, and whether these changes are associated with differences in left ventricular hypertrophy. PUBLIC HEALTH RELEVANCE: Project Narrative This is a proposed ancillary study to the Frequent ..
  27. Epigenetic Regulation of Cardiac Hypertrophy and Heart Failure
    Zhi Ping Liu; Fiscal Year: 2013
    ..heart undergoes a series of histopathological and structural changes (cardiac remodeling), including left ventricular hypertrophy (LVH) that can progress to heart failure...
  28. Arterial Structure and Function and Atrial Fibrillation
    Lin Yee Chen; Fiscal Year: 2013
    ..for this association: structural and functional changes in the vasculature lead to hypertension, left ventricular hypertrophy, and finally, structural remodeling in the atria. However, several knowledge gaps remain...
  29. FGF-23 and clinical outcomes in ADPKD patients
    MYLES S WOLF; Fiscal Year: 2013
    ..b>Left ventricular hypertrophy is an important manifestation of cardiovascular disease in ADPKD with an incidence that is twice as ..
  30. STIM1 mediated calcium entry: A new paradigm of metabolic regulation of cardiomyo
    John C Chatham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Left ventricular hypertrophy (LVH) and diabetes are among the most potent risk factors for the development of heart failure;furthermore, the combination of diabetes with additional risk factors such ..
  31. Morbidity and Mortality Relating to Gastric Bypass Surgery
    Steven C Hunt; Fiscal Year: 2013
    ..Echocardiograms for left ventricular hypertrophy, heart structure and function, CT scans for coronary calcium, epicardial fat and visceral fat, as well ..
  32. Intracellular Sorting of Connexin 43 by the Ubiquitin Ligase Wwp1
    LYDIA ELEANOR MATESIC; Fiscal Year: 2013
    ..Grossly, HCM is characterized by left ventricular hypertrophy (LVH) in the absence of identifiable clinical causes...
  33. Genome Wide Haplotype Association Analysis
    Nianjun Liu; Fiscal Year: 2012
    ..generated in our collaborators'ongoing projects, including data sets concerning genetic effects on left ventricular hypertrophy, rheumatoid arthritis, and obesity...
  34. Health Disparities and CVD: Admixture Mapping in the Jackson Heart Study
    JAMES GRAHAM WILSON; Fiscal Year: 2010
    ..differences in prevalence between African Americans and Europeans: hypertension, serum lipid levels, left ventricular hypertrophy, and low birth weight...
  35. Predictors of Coronary Artery Calcification in an African-American Cohort
    PATRICIA PEYSER; Fiscal Year: 2010
    ..g., hypertension) and associated co-morbidities (e.g., end stage renal disease and left ventricular hypertrophy), poor risk factor control, and reduced access to care are likely contributors to some, but not all, ..
  36. Improving Cardiovascular Outcomes in Individuals with a History of Incarceration
    EMILY AI HUA WANG; Fiscal Year: 2013
    ..has shown that having a history of incarceration is an independent risk for developing hypertension and left ventricular hypertrophy, even after adjusting for confounding factors...
  37. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2013
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. Specific aims: #1...
  38. Mentored Patient Oriented Research in Mineral Metabolism
    MYLES S WOLF; Fiscal Year: 2013
    ..we recently demonstrated that elevated FGF23 contributes causally to the frequent development of left ventricular hypertrophy in CKD patients...
  39. Pilot Studies Targeting Mineral Metabolism in Chronic Kidney Disease
    MYLES S WOLF; Fiscal Year: 2013
    ..validated by new preliminary data, suggest potential underlying pathogenic mechanisms: FGF23 induces left ventricular hypertrophy and accelerates CKD progression, and phosphate excess and klotho deficiency induce arterial ..
  40. Role of FGF23 in Mineral Metabolism Across the Spectrum of Chronic Kidney Disease
    MYLES S WOLF; Fiscal Year: 2013
    ..Elevated FGF23 contributes directly to the pathogenesis of left ventricular hypertrophy, suggesting one potential mechanism for the high risk of CVD and death that is attributable to elevated ..
  41. FGF23 and Cardiovascular Disease in CKD
    MYLES S WOLF; Fiscal Year: 2013
    ..that elevated FGF23 is likely a mechanism of disease that contributes directly to the pathogenesis of left ventricular hypertrophy, which is a common manifestation of cardiovascular disease in CKD and a leading risk factor for major ..
  42. Adjunct vitamin D therapy as a means to reduce the disparity in subclinical targe
    PHILLIP DAVID LEVY; Fiscal Year: 2013
    ..Specifically, we seek to ascertain the effect of adjunct vitamin D therapy on left ventricular hypertrophy (primary aim), myocardial fibrosis and central vascular function (secondary aims) at one-year using a ..
  43. Leukocyte Telomere Length and Cardiovascular Disease in Jackson Heart Study
    JAMES GRAHAM WILSON; Fiscal Year: 2013
    ..been found to be relatively short in patients with atherosclerosis and relatively long in patients with left ventricular hypertrophy (LVH)...
  44. HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY
    Donna K Arnett; Fiscal Year: 2013
    ....
  45. SPRINT - Heart
    Dalane W Kitzman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Left ventricular hypertrophy (LVH) is very common, is a strong independent predictor of major adverse cardiovascular (CV) events and mortality, and has a large attributable population risk...
  46. Research Centers in Minority Institutions Clinical Rese*
    Eve Higginbotham; Fiscal Year: 2009
    ..is characterized by a more virulent course, a higher prevalence of target organ damage such as left ventricular hypertrophy (LVH), heart failure and renal failure...
  47. Mechanisms of Myocardial Recovery
    CRAIG HAROLD SELZMAN; Fiscal Year: 2013
    ..and in particular, understanding and preventing the transition from adaptive to maladaptive left ventricular hypertrophy (LVH)...
  48. Subclinical and clinical heart disease and the effect on kidney injury and diseas
    Meyeon Park; Fiscal Year: 2013
    ..S. Small studies have found that left ventricular hypertrophy and subclinical cardiovascular disease are predictors of progression of CKD in non-diabetic patients ..
  49. Dysregulated Angiogenesis in ADPKD
    BERENICE YOLANDE GITOMER; Fiscal Year: 2013
    ..Moreover, early onset of hypertension in ADPKD patients and increased incidence of left ventricular hypertrophy are associated with heightened mortality risk...
  50. Cardiac Myocycte-Role of PKG I Alpha in Aging-Dependent Cardiac Remodeling
    ROBERT MORRIS BLANTON; Fiscal Year: 2013
    ..In the baseline state, the LZM mice develop progressive, age-related left ventricular hypertrophy (LVH), a key component of remodeling...
  51. GWAS Using Integrated CNV and SNP Information
    Rui Feng; Fiscal Year: 2013
    ..publicly available HapMap data and human data sets from our collaborators studying genetic effects on left ventricular hypertrophy, triglycerides, and blood pressure...
  52. Coronary calcification in hemodialysis patients
    Sylvia Rosas; Fiscal Year: 2009
    ..Vascular calcification (VC) which leads to arterial stiffness and left ventricular hypertrophy is likely to be a major contributant to the pathology...
  53. Patient Oriented Studies of Vitamin D in Chronic Kidney Disease
    Ravi Thadhani; Fiscal Year: 2013
    ..and ex-vivo response to infection;(2) in PRIMO - an industry sponsored trial of active vitamin D and left ventricular hypertrophy [LVH], diastolic function, and cardiac hospitalization in patients with stage 3/4 CKD - his team will ..
  54. EPIDEMIC HYPERTENSION IN NIGERIAN WORKERS
    Clareann Bunker; Fiscal Year: 1999
    ..There was a high prevalence of left ventricular hypertrophy, based on ECG voltage criteria (ECG-LVH), in both Senior and Junior staff, males and females, which was ..
  55. MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
    Donald R Menick; Fiscal Year: 2013
    ..microtubule network density is one cause of contractile dysfunction in high wall stress right or left ventricular hypertrophy. We then showed that increased affinity of microtubule-associated protein 4 [MAP4] for microtubules is ..
  56. Pathways influencing left ventricular hypertrophy in hemodialysis patients
    Christopher T Chan; Fiscal Year: 2012
    ..The results from this ancillary study proposal will provide unique biological insights into the mechanisms and potential therapeutic targets to improve the health of patients receiving dialysis in North America. ..
  57. Functional GWAS for LVH using iPS-derived Cardiomyocytes: The HyperGEN ciPS Stud
    Junying Yu; Fiscal Year: 2013
    ..one of the largest multi-ethnic genome-wide association studies for Left Ventricular Mass (LVM) and Left Ventricular Hypertrophy (LVH)...
  58. IDENTIFYING HIGH RISK PATIENTS WITH SYNCOPE
    Wishwa Kapoor; Fiscal Year: 1991
    ..predictors included a history of diabetes mellitus, renal insufficiency (creatinine greater than 2), left ventricular hypertrophy, left bundle branch block and left axis deviation...
  59. Executive Function in Children with Hypertension
    Marc B Lande; Fiscal Year: 2013
    ..Hypertensive children often manifest evidence of target organ damage such as left ventricular hypertrophy. Studies show that young adults with hypertension have decreased performance on neurocognitive testing ..
  60. Impact of vitamin D supplementation on cardiac structure and function
    Thomas J Wang; Fiscal Year: 2013
    ..by applicant): Experimental and observational data suggest that vitamin D supplementation reduces left ventricular hypertrophy and improves cardiac function. Prospective clinical data, however, are lacking...
  61. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ..disease [PAD]) as well as the progression of sub-clinical CVD (coronary artery calcification score, left ventricular hypertrophy identified by Echo, and ankle-brachial index) among patients with CKD...
  62. ADAPTATIONS TO EXERCISE IN OLDER HYPERTENSIVE SUBJECTS
    Ali Ehsani; Fiscal Year: 2000
    ..to determine whether endurance exercise-training can lower blood pressure (BP) and induce regression of left ventricular hypertrophy (LVH) in older hypertensive men and women...
  63. AUTONOMIC RECEPTOR FUNCTION IN LV HYPERTROPHY & FAILURE
    Dorothy Vatner; Fiscal Year: 1991
    ..alterations in beta-adrenergic and muscarinic receptor function and adenylate cyclase activity in left ventricular hypertrophy and failure...
  64. CARDIAC GROWTH REGULATION
    Kaie Ojamaa; Fiscal Year: 1999
    The heart responds to various hemodynamic and humoral stimuli by changes in myocyte size and function. Left ventricular hypertrophy such as arises from hypertension or valvular disease is a sensitive predictor for morbidity and mortality ..
  65. ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMM
    Marco Di Tullio; Fiscal Year: 2003
    ..A population-based prospective cohort study is proposed to determine the independent contribution of left ventricular hypertrophy (LVH) and geometric pattern, decreased LV ejection fraction, segmental wall motion abnormalities and ..
  66. EFFECT OF HYPERTENSION AND HYPERTROPHY ON LV ISCHEMIA
    PETER ROAN; Fiscal Year: 1980
    b>Left ventricular hypertrophy (LVH), hypertension and atherosclerotic coronary arterial disease commonly coexist...
  67. MYOCARDIAL FA METABOLISM GENE-GENE INTERACTIONS IN HYPERTENSIVE HEART DISEASE
    Lisa De Las Fuentes; Fiscal Year: 2010
    ..Hypertensive heart disease (HHD) results from long-standing hypertension (HTN) and manifests early as left ventricular hypertrophy (LVH) and/or left ventricular diastolic dysfunction (LVDD)...
  68. Role of H11 kinase in cardiac cell growth
    Christophe Depre; Fiscal Year: 2007
    ..and protein are upregulated in large mammalian models of reversible ischemia/reperfusion and chronic left ventricular hypertrophy. Our preliminary data show that overexpression of H11 kinase in isolated cardiac myocytes promotes cell ..
  69. CONTRACTILE PERFORMANCE OF HYPERTROPHIED CARDIOCYTES
    Douglas Mann; Fiscal Year: 1991
    ..this technique will be used to study the contractile function of cardiocytes isolated from right and left ventricular hypertrophy models during exposure of such cells to two sets of defined in vitro loading conditions: first, ..
  70. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2007
    ..provided by applicant): Plasma natriuretic peptide levels are markedly elevated in individuals with left ventricular hypertrophy (LVH), one of the key precursors of diastolic heart failure (DHF)...