tachycardia

Summary

Summary: Excessive rapidity in the action of the heart, usually with a heart rate above 100 beats per minute.

Top Publications

  1. ncbi Intracellular calcium changes and tachycardia-induced contractile dysfunction in canine atrial myocytes
    H Sun
    Research Center and Department of Medicine, Montreal Heart Institute, Departments of Medicine and Physiology, University of Montreal, and Department of Pharmacology, McGill University, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8, Canada
    Cardiovasc Res 49:751-61. 2001
  2. ncbi Video-assisted thoracoscopy to treat atrial tachycardia arising from left atrial appendage
    Yuichiro Yamada
    Department of Cardiology, Tokyo Women s Medical University, Tokyo, Japan
    J Cardiovasc Electrophysiol 17:895-8. 2006
  3. ncbi Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 69:865-75. 2006
  4. ncbi The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome
    E M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Neurology 69:790-8. 2007
  5. ncbi Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection
    Gina Sanchez
    Programa de Fisiopatología, Instituto de Ciencias Biomédicas y Centro FONDAP de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Chile
    Cardiovasc Res 77:380-6. 2008
  6. ncbi Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats
    Arvinder K Dhalla
    Department of Pharmacology, CV Therapeutics, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 316:695-702. 2006
  7. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
  8. ncbi Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia
    Terry Ketch
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Circulation 105:2518-23. 2002
  9. pmc Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more
    Satish R Raj
    Departments of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 120:725-34. 2009
  10. ncbi Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome
    N Muenter Swift
    Department of Neurology Autonomic Disorders Center, Mayo Clinic, 200 First St SW, Charlton 7 271A, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H1226-33. 2005

Detail Information

Publications281 found, 100 shown here

  1. ncbi Intracellular calcium changes and tachycardia-induced contractile dysfunction in canine atrial myocytes
    H Sun
    Research Center and Department of Medicine, Montreal Heart Institute, Departments of Medicine and Physiology, University of Montreal, and Department of Pharmacology, McGill University, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8, Canada
    Cardiovasc Res 49:751-61. 2001
    ..Indirect evidence suggests a role for Ca(2+)-overload in electrical and mechanical alterations caused by atrial tachycardia. The present study assessed the alterations in cellular [Ca(2+)] and contractile function caused by rapid ..
  2. ncbi Video-assisted thoracoscopy to treat atrial tachycardia arising from left atrial appendage
    Yuichiro Yamada
    Department of Cardiology, Tokyo Women s Medical University, Tokyo, Japan
    J Cardiovasc Electrophysiol 17:895-8. 2006
    A 17-year-old male with tachycardia-induced cardiomyopathy presented with persistent, drug-resistant atrial tachycardia (AT)...
  3. ncbi Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 69:865-75. 2006
    ..This study evaluated the efficacy of anti-inflammatory and calcineurin-inhibitory drugs on promotion of atrial fibrillation by atrial tachycardia-induced remodeling in dogs.
  4. ncbi The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome
    E M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Neurology 69:790-8. 2007
    Previous studies of patients with postural tachycardia syndrome (POTS) have been hampered by relatively small cohorts, failure to control medications and diet, and inconsistent testing procedures.
  5. ncbi Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection
    Gina Sanchez
    Programa de Fisiopatología, Instituto de Ciencias Biomédicas y Centro FONDAP de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Chile
    Cardiovasc Res 77:380-6. 2008
    ..investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct size following coronary artery occlusion.
  6. ncbi Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats
    Arvinder K Dhalla
    Department of Pharmacology, CV Therapeutics, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 316:695-702. 2006
    Adenosine-induced tachycardia is suggested to be mediated via A(2A) receptors; however, the exact mechanism for this effect remains to be understood...
  7. pmc Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients
    A V Postma
    J Med Genet 42:863-70. 2005
    The aim of the study was to assess underlying genetic cause(s), clinical features, and response to therapy in catecholaminergic polymorphic ventricular tachycardia (CPVT) probands.
  8. ncbi Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia
    Terry Ketch
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Circulation 105:2518-23. 2002
    ..Such excursions may derive from endogenous factors such as stress or drowsiness, which result in quite high and quite low pressures, respectively. They may also derive from exogenous factors such as drugs or environmental influences...
  9. pmc Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more
    Satish R Raj
    Departments of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 120:725-34. 2009
    Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate on standing...
  10. ncbi Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome
    N Muenter Swift
    Department of Neurology Autonomic Disorders Center, Mayo Clinic, 200 First St SW, Charlton 7 271A, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H1226-33. 2005
    Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia during orthostasis...
  11. ncbi The postural tachycardia syndrome
    Marvin S Medow
    Department of Pediatrics, New York Medical College, Valhalla, New York 10598, USA
    Cardiol Rev 15:67-75. 2007
    Postural tachycardia syndrome (POTS) is a disorder of unknown etiology, and patients with this condition exhibit orthostatic intolerance (OI) and excessive tachycardia...
  12. ncbi Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow
    Julian M Stewart
    Department of Pediatrics, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 291:H904-13. 2006
    Previous investigations have demonstrated a subset of postural tachycardia syndrome (POTS) patients characterized by normal peripheral resistance and blood volume while supine but thoracic hypovolemia and splanchnic blood pooling while ..
  13. ncbi Diabetic cardiovascular autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Circulation 115:387-97. 2007
  14. ncbi Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling
    Brett Burstein
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Canada
    Cardiovasc Res 76:442-52. 2007
    Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia...
  15. pmc Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Heart Rhythm 6:546-52. 2009
    ..In HRV power spectral analysis, the low-frequency (LF) component diminishes in patients with CHF and the decrease is related to an increased risk of sudden death...
  16. ncbi Spontaneous pulmonary vein firing in man: relationship to tachycardia-pause early afterdepolarizations and triggered arrhythmia in canine pulmonary veins in vitro
    Eugene Patterson
    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Cardiovasc Electrophysiol 18:1067-75. 2007
    ..Rapid firing originating within pulmonary veins (PVs) initiates atrial fibrillation (AF). The following studies were performed to evaluate spontaneous PV firing in patients with AF to distinguish focal versus reentrant mechanisms...
  17. ncbi Blood volume perturbations in the postural tachycardia syndrome
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
    Am J Med Sci 334:57-60. 2007
    The postural tachycardia syndrome (POTS) is characterized by excessive orthostatic tachycardia with chronic symptoms that are associated with upright posture...
  18. ncbi Correlates of functional disability in patients with postural tachycardia syndrome: preliminary cross-sectional findings
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Health Psychol 22:643-8. 2003
    ..4% women, 10.6% men; mean age=34.2 years) with postural tachycardia syndrome (POTS), a clinical syndrome of orthostatic intolerance characterized by significant functional ..
  19. ncbi Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle
    Gina Sanchez
    Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70005, Santiago 7, Chile
    J Mol Cell Cardiol 39:982-91. 2005
    We have shown previously that electrically induced tachycardia effectively produces myocardial preconditioning...
  20. ncbi Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome
    Satish R Raj
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 111:1574-82. 2005
    Patients with postural tachycardia syndrome (POTS) experience considerable disability, but in most, the pathophysiology remains obscure. Plasma volume disturbances have been implicated in some patients...
  21. ncbi Intrinsic cardiac nervous system in tachycardia induced heart failure
    Rakesh C Arora
    Centre de Recherche, Hôpital du Sacré Coeur, 5400 Boulevard Gouin Ouest, Montreal, QC, Canada H4J 1C5
    Am J Physiol Regul Integr Comp Physiol 285:R1212-23. 2003
    ....
  22. ncbi Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome
    C J Mathias
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    Eur J Neurol 11:613-9. 2004
    ..diseases who have orthostatic intolerance, on the mechanisms that could be involved, and on whether this pressor response may be used in the management of orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome.
  23. ncbi Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trial
    Peter J Zimetbaum
    Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston, Mass 02215, USA
    Circulation 110:766-9. 2004
    ..We assessed the prognostic significance of ECG markers of conduction abnormalities and left ventricular hypertrophy in the Multicenter Unsustained Tachycardia Trial (MUSTT).
  24. pmc Autonomic nervous system activity measured directly and QT interval variability in normal and pacing-induced tachycardia heart failure dogs
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Am Coll Cardiol 54:840-50. 2009
    This study sought to find out more about the relationship between sympathetic and vagal nerve activity and the cardiac repolarization in a canine model of pacing-induced tachycardia congestive heart failure (CHF).
  25. ncbi Atrial tachycardia/fibrillation in the connexin 43 G60S mutant (Oculodentodigital dysplasia) mouse
    Jari M Tuomi
    Department of Physiology and Pharmacology, University of Western Ontario, London, Canada
    Am J Physiol Heart Circ Physiol 300:H1402-11. 2011
    ..Cx43(G60S/+) mice were compared with Cx40-deficient (Cx40(-/-)) mice to determine the role of Cxs in atrial tachycardia/fibrillation (AT/F)...
  26. pmc Sudden death in patients receiving drugs tending to prolong the QT interval
    Kate Jolly
    Schools of Health and Population Sciences, University of Birmingham College of Medicine and Dental Sciences, Birmingham, UK
    Br J Clin Pharmacol 68:743-51. 2009
    ..To examine risks of sudden death in the community associated with drugs grouped by their risk of causing torsades de pointes (TdP) and to explore the risks for individual drugs...
  27. pmc Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis
    Khalil Kanjwal
    Department of Medicine, Division of Cardiology Section of Electrophysiology, The University of Toledo, Toledo, OH 43614, USA
    Int J Med Sci 7:62-7. 2010
    ..However, there have been no reports on postural orthostatic tachycardia syndrome (POTS) in patients suffering from MS.
  28. ncbi Intraoperative tachycardia and hypertension are independently associated with adverse outcome in noncardiac surgery of long duration
    David L Reich
    Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Anesth Analg 95:273-7, table of contents. 2002
    ..095; P = 0.009) were associated with NSO in longer operations. Thus, intraoperative tachycardia and hypertension were associated independently with adverse outcomes after major noncardiac surgery of long ..
  29. ncbi Development of porcine model of chronic tachycardia-induced cardiomyopathy
    Urszula Paslawska
    Regional Specialist Hospital in Wroclaw, Research and Development Centre, Wroclaw, Poland
    Int J Cardiol 153:36-41. 2011
    There are few experimental models of heart failure (HF) in large animals, despite structural and functional similarities to human myocardium. We have developed a porcine model of chronic tachycardia-induced cardiomyopathy.
  30. ncbi Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia
    Nian Liu
    Cardiovascular Genetics Program, The Leon H Charney Division of Cardiology, New York University School of Medicine, New York, USA
    J Mol Cell Cardiol 50:214-22. 2011
    Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease characterized by life-threatening arrhythmias elicited by adrenergic activation...
  31. ncbi Cerebral autoregulation is preserved in postural tachycardia syndrome
    Ronald Schondorf
    Autonomic Reflex Laboratory, Dept of Neurology, McGill University, Sir Mortimer B Davis Jewish General Hospital, 3755 Chemin de la Cote St Catherine, Montreal Quebec, Canada H3T 1E2
    J Appl Physiol (1985) 99:828-35. 2005
    To test whether cerebral autoregulation is impaired in patients with postural tachycardia syndrome (POTS), we evaluated 17 healthy control subjects and 27 patients with POTS...
  32. ncbi Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages
    C C Hoppe
    Department of Anatomy, Monash University, Melbourne, Victoria, Australia
    Physiol Res 58:69-75. 2009
    ..These results demonstrate sustained changes in cardiovascular function when mice are housed in metabolism cages, which could potentially affect renal function...
  33. ncbi Histamine induces postprandial tachycardia through a direct effect on cardiac H2-receptors in pythons
    Nini Skovgaard
    Dept of Biological Sciences, Univ of Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 296:R774-85. 2009
    ..during digestion, suggesting that a nonadrenergic-noncholinergic factor contributes to the postprandial tachycardia. The regulating factor, however, remains elusive and difficult to identify...
  34. ncbi The postural tachycardia syndrome: a concise guide to diagnosis and management
    Blair P Grubb
    Electrophysiology Section, Division of Cardiology, Department of Medicine, The Medical University of Ohio, Toledo, Ohio 43614, USA
    J Cardiovasc Electrophysiol 17:108-12. 2006
  35. ncbi Induction of atrial tachycardia and fibrillation in the mouse heart
    H Wakimoto
    Department of Cardiology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Cardiovasc Res 50:463-73. 2001
    BACKGROUND: Atrial tachycardia and fibrillation in humans may be partly consequent to vagal stimulation. Induction of fibrillation in the small heart is considered to be impossible due to lack of a critical mass of > 100-200 mm2...
  36. doi Postural tachycardia syndrome
    Blair P Grubb
    Department of Medicine, University of Toledo, 3000 Arlington Ave, Toledo, Ohio 43614, USA
    Circulation 117:2814-7. 2008
  37. ncbi Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor β1
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, No 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    Cardiovasc Res 89:805-15. 2011
    ..We investigated the molecular mechanism of rapid-depolarization-induced atrial fibrosis...
  38. ncbi Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis
    Eiichiro Yamamoto
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    J Hypertens 24:2057-69. 2006
    To examine the mechanism and significance of tachycardia-induced cardiac damage, using azelnidipine, a relatively new dihydropyridine calcium channel blocker which does not increase heart rate.
  39. ncbi Quality of life in patients with postural tachycardia syndrome
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 77:531-7. 2002
    To quantify quality of life and identify demographic and clinical correlates of functioning in a well-characterized sample of patients with postural tachycardia syndrome (POTS).
  40. pmc Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles
    Andreas Goette
    Division of Cardiology, University Hospital Magdeburg, Otto von Guericke University, Leipzigerstr 44, 39120 Magdeburg, Germany
    Eur Heart J 30:1411-20. 2009
    ..However, in a large proportion of these patients, significant coronary artery disease is excluded by coronary angiography. Here we explored the potential underlying mechanism of these events...
  41. ncbi Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes
    Niels Voigt
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Cardiovasc Res 77:35-43. 2008
    Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (I K,ACh) that increases susceptibility to atrial fibrillation (AF), the underlying changes in I K,Ach ..
  42. ncbi Does tachycardia correlate with hypotension after trauma?
    Gregory P Victorino
    Department of Surgery, University of California, San Francisco East Bay, Oakland, California 94602, USA
    J Am Coll Surg 196:679-84. 2003
    b>Tachycardia is believed to be closely associated with hypotension and is often listed as an important sign in the initial diagnosis of hemorrhagic shock, but the correlation between heart rate and hypotension remains unproved.
  43. pmc Bidirectional ventricular tachycardia: ping pong in the His-Purkinje system
    Alex A Baher
    Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Heart Rhythm 8:599-605. 2011
    Bidirectional ventricular tachycardia (BVT), which is characterized by an alternating beat-to-beat ECG QRS axis, is a rare but intriguing arrhythmia associated with digitalis toxicity, familial catecholaminergic polymorphic ventricular ..
  44. ncbi Focal atrial tachycardia arising from the tricuspid annulus: electrophysiologic and electrocardiographic characteristics
    J B Morton
    Department of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia
    J Cardiovasc Electrophysiol 12:653-9. 2001
    INTRODUCTION: Focal right atrial tachycardia (RAT) arising from the crista terminalis, para-Hisian, and coronary sinus os regions are well described...
  45. ncbi Ruthenium red-induced transition from ventricular fibrillation to tachycardia in isolated rat hearts: possible involvement of changes in mitochondrial calcium uptake
    Koichi Kawahara
    Laboratory of Biomedical Control, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    Cardiovasc Pathol 12:311-21. 2003
    Ventricular tachycardia (VT) is considered to be the most common precursor of ventricular fibrillation (VF) and sudden cardiac death...
  46. pmc Enhanced QT shortening and persistent tachycardia after generalized seizures
    Rainer Surges
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 74:421-6. 2010
    ..Generalized tonic-clonic seizures (GTCS) are a major risk factor for sudden unexpected death in epilepsy (SUDEP). We investigated whether ictal/postictal cardiac features were dependent on seizure type within individual patients...
  47. ncbi Fever and tachycardia in a bird (Gallus domesticus) after simple handling
    M Cabanac
    Departement de Physiologie, Universite Laval, Quebec, Canada
    Physiol Behav 69:541-5. 2000
    ..When simply touched by an experimenter, the birds' mean heart rate rose from 198 +/- 6 to 249 +/- 15 beats/min. We conclude that fever and tachycardia might indicate the existence of emotion in birds.
  48. ncbi Early versus late postural tachycardia: a re-evaluation of a syndrome
    Kenneth A Mayuga
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Auton Res 18:155-7. 2008
    Postural tachycardia syndrome (POTS) involves an HR-rise within 10 minutes of head-up tilt...
  49. pmc Frequency and predictors of tachycardia-induced cardiomyopathy in patients with persistent atrial flutter
    Stephen Pizzale
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 25:469-72. 2009
    There are few data on the frequency and predictors of tachycardia-induced cardiomyopathy (TICM) in patients with persistent atrial flutter.
  50. ncbi Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation
    Nana Duhme
    Institute for Physiology and Pathophysiology, University of Heidelberg, INF 326, Heidelberg D 69120, Germany
    Eur Heart J 34:2768-75. 2013
    ..We asked whether dysfunctional HCN4 channels also contribute to the generation of cardiac tachyarrhythmias...
  51. ncbi Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction
    Yosuke Nakatani
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Am Coll Cardiol 61:582-8. 2013
    ..This study sought to assess the effects of tranilast on atrial remodeling in a canine atrial fibrillation (AF) model...
  52. pmc Expression and complex formation of MMP9, MMP2, NGAL, and TIMP1 in porcine myocardium but not in skeletal muscles in male pigs with tachycardia-induced systolic heart failure
    Liliana Kiczak
    Regional Specialist Hospital in Wroclaw, Research and Development Centre, Wroclaw, Poland
    Biomed Res Int 2013:283856. 2013
    ..In skeletal muscles from both diseased and healthy animals, in nonreducing and nondenaturing conditions, we found no HMW complexes, and proteolytic activity was associated with the presence of 72 and 68 kDa bands (proMMP2 and MMP2)...
  53. ncbi EP₃ receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats
    Hanna Kozłowska
    Department of Physiology and Pathophysiology, Medical University of Bialystok, Mickiewicza 2A, PL 15 089 Białystok, Poland
    Pharmacol Rep 64:1526-36. 2012
    ..of EP(3) receptors in human pulmonary arteries and (2) the examination of the potential involvement of these receptors in the regulation of neurogenic tachycardia in pithed rats. L-826266 served as the EP(3) receptor antagonist.
  54. ncbi Catheter ablation of right ventricular outflow tract tachycardia: a simplified remote-controlled approach
    Melanie Konstantinidou
    Department of Cardiology, Asklepios Klinik St Georg, Lohmuhlenstrasse 5, Hamburg, Germany
    Europace 13:696-700. 2011
    Manual mapping and ablation of right ventricular outflow tract (RVOT) tachycardia may be associated with cardiac perforation and complicated by mechanically induced ventricular extrasystoles (VESs)...
  55. ncbi Tachycardia-induced cardiomyopathy: a review of literature
    Atul Khasnis
    Division of Cardiology, Department of Internal Medicine, Michigan State University, East Lansing, MI 48910, USA
    Pacing Clin Electrophysiol 28:710-21. 2005
  56. pmc Rapid pacing of embryoid bodies impairs mitochondrial ATP synthesis by a calcium-dependent mechanism--a model of in vitro differentiated cardiomyocytes to study molecular effects of tachycardia
    Lorenz Schild
    Institute of Clinical Chemistry, Department of Pathobiochemistry, Otto von Guericke University Magdeburg, and Division of Cardiology, University Hospital Magdeburg, Germany
    Biochim Biophys Acta 1762:608-15. 2006
    b>Tachycardia may cause substantial molecular and ultrastructural alterations in cardiac tissue. The underlying pathophysiology has not been fully explored...
  57. ncbi Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis
    Tae Joon Cha
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 111:728-35. 2005
    The pulmonary veins (PVs) are important in the pathophysiology of atrial fibrillation (AF), as is atrial tachycardia (AT) remodeling. The relative importance of AT remodeling in PVs versus other atrial sites is unknown...
  58. ncbi Prevention of myocardial dysfunction by Eplerenon in experimental tachycardiomyopathy
    Juan Cosin-Aguilar
    Cardiocirculatory Unit, Research Center, Hospital La Fe, Valencia, Spain
    Med Sci Monit 15:BR141-7. 2009
    ..The aim was to study the factors that determine the persistence of myocardial dysfunction when ventricular tachycardia has ceased and hemodynamic conditions have been restored.
  59. ncbi Improvement of cardiac function and neurological remodeling in a patient with tachycardia-induced cardiomyopathy after catheter ablation
    Chikaya Omichi
    Division of Cardiology, Cardiovascular Center, Kitahara Hospital, 1 7 23 Owada cho, Hachioji, Tokyo 192 0045, Japan
    J Cardiol 54:134-8. 2009
    Incessant ventricular tachycardia and long-standing ectopic beats lead to tachycardia-induced cardiomyopathy. Catheter ablation eliminates ventricular tachycardia and reverses left ventricular (LV) dysfunction...
  60. pmc Influence of baroreflex-mediated tachycardia on the regulation of dynamic cerebral perfusion during acute hypotension in humans
    Shigehiko Ogoh
    Department of Biomedical Engineering, Toyo University, Kawagoe shi, Saitama, Japan
    J Physiol 588:365-71. 2010
    ..We identified dynamic CA with and without arterial baroreflex-mediated tachycardia and consequent changes in cardiac output during acute hypotension whilst continuously monitoring changes in ..
  61. ncbi Reduced stroke volume during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1128-35. 2007
    Postural tachycardia syndrome (POTS) is characterized by excessive tachycardia without hypotension during orthostasis. Most POTS patients also report exercise intolerance...
  62. ncbi Dopamine-beta-hydroxylase in postural tachycardia syndrome
    Emily M Garland
    Autonomic Dysfunction Center, AA3228 Medical Center North, Vanderbilt University, Nashville, TN 37232 2195, USA
    Am J Physiol Heart Circ Physiol 293:H684-90. 2007
    Norepinephrine is frequently elevated in postural tachycardia syndrome (POTS), a syndrome of heterogeneous etiology characterized by a >30 beats/min increase in heart rate with standing...
  63. ncbi Tachycardia in hypertension: a saga of progress despite prejudice, confusion, and inertia
    Stevo Julius
    University of Michigan Cardiovascular Center, Ann Arbor, MI, USA
    Prog Cardiovasc Dis 52:26-30. 2009
    b>Tachycardia is a strong predictor of both hypertension and excessive cardiovascular risk. This association is robust and prevails after multivariate adjustments for other cardiovascular risk factors...
  64. ncbi A pharmacodynamic study on clenbuterol-induced toxicity: beta1- and beta2-adrenoceptors involvement in guinea-pig tachycardia in an in vitro model
    Gabriela Mazzanti
    Department of Human Physiology and Pharmacology, University La Sapienza, P le Aldo Moro, 5 00185 Rome, Italy
    Food Chem Toxicol 45:1694-9. 2007
    ..Following consumption of meat or liver, intoxication cases were described, and cardiovascular toxic effects (tachycardia, hypertension) were of clinical relevance...
  65. ncbi Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome
    Istvan Bonyhay
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Neurol 61:332-9. 2007
    To elucidate the mechanisms whereby postural tachycardia syndrome (POTS) patients maintain orthostatic blood pressure and explain the greater prevalence of female cases in POTS cohorts.
  66. ncbi Elevated heart rate in cardiovascular diseases: a target for treatment?
    Paolo Palatini
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Prog Cardiovasc Dis 52:46-60. 2009
    ..Treatment of high heart rate in healthy subjects appears to be premature, but in clinical conditions such as hypertension or diabetes, the reduction of elevated heart rate appears a desirable additional goal of therapy...
  67. ncbi Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency
    J R Shannon
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville 37232 2195, USA
    N Engl J Med 342:541-9. 2000
    ..syndrome characterized by lightheadedness, fatigue, altered mentation, and syncope and associated with postural tachycardia and plasma norepinephrine concentrations that are disproportionately high in relation to sympathetic outflow...
  68. ncbi Comparative study of cerebral blood flow between postural tachycardia and neurocardiogenic syncope, during head-up tilt test
    A G Hermosillo
    Departamento de Electrofisiologia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico DF
    Europace 4:369-74. 2002
    ..to head-up tilt test in patients with typical neurocardiogenic syncope compared with patients showing postural tachycardia. Fifty patients (21 men) with history of orthostatic intolerance, younger than 50 years (mean 27 +/- 10), ..
  69. ncbi Characteristics of congestive heart failure accompanied by atrial fibrillation with special reference to tachycardia-induced cardiomyopathy
    Tadashi Fujino
    Cardiovascular Institute Hospital, Department of Cardiovascular Medicine, Toho University Omori Medical Center, 6 11 1 Omorinishi, Ota ku, Tokyo 143 8541, Japan
    Circ J 71:936-40. 2007
    Sustained tachycardia causes left ventricular (LV) systolic dysfunction leading to heart failure (HF), which is widely known as "tachycardia-induced cardiomyopathy (TIC)", but its prevalence and prognosis in Japanese remain unclear.
  70. ncbi Successful catheter ablation of incessant atrial tachycardia in pregnancy using three-dimensional electroanatomical mapping with minimal radiation
    H Wu
    Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Intern Med J 42:709-12. 2012
    ..We report a pregnant woman who underwent successful ablation of focal atrial tachycardia using three-dimensional electroanatomical mapping with minimal radiation exposure.
  71. ncbi New simplified technique for 3D mapping and ablation of right ventricular outflow tract tachycardia
    Moeen A Saleem
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Pacing Clin Electrophysiol 28:397-403. 2005
    To evaluate the safety and efficacy of using a circular multielectrode catheter for mapping and ablation of ventricular tachycardia (VT) or premature ventricular complexes (PVCs) from the right ventricular outflow tract (RVOT).
  72. ncbi Do we need a reflex tachycardia to stand up?
    Jacques Olivier Fortrat
    Laboratoire de Physiologie, Faculte de Medecine, Centre Hospitalo Universitaire, Faculte de Medecine, 49045 Angers Cedex, France
    Pacing Clin Electrophysiol 28:962-7. 2005
    ..We hypothesized that this approach would improve the cardiovascular response to standing in comparison with a regular pacing mode...
  73. ncbi Heart failure and sudden death in patients with tachycardia-induced cardiomyopathy and recurrent tachycardia
    Pamela Nerheim
    University of Iowa Hospitals, Iowa City, IA 52242 1081, USA
    Circulation 110:247-52. 2004
    b>Tachycardia-induced cardiomyopathy is a reversible cause of heart failure...
  74. ncbi Implications of progressive aberrancy versus true fusion for diagnosis of wide complex tachycardia
    Eugene Greenstein
    Division of Cardiology, Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois, USA
    Am J Cardiol 108:52-5. 2011
    At the onset of wide complex tachycardia, beats with intermediate morphologies sometimes occur between the normally conducted beats and the wide complex tachycardia QRS...
  75. ncbi Endothelial NO synthase polymorphisms and postural tachycardia syndrome
    Emily M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 46:1103-10. 2005
    Postural tachycardia syndrome (POTS) is a heterogeneous disorder characterized by an excessive rise in heart rate and symptoms consistent with cerebral hypoperfusion in the upright position...
  76. ncbi Assessment of atrial regional wall motion using strain Doppler imaging during biatrial pacing in the bradycardia-tachycardia syndrome
    Katsumi Matsumoto
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    Pacing Clin Electrophysiol 29:220-5. 2006
    ..Biatrial pacing is expected to have preventive effects on atrial fibrillation...
  77. ncbi Efficacy and safety of oral propranolol premedication to reduce reflex tachycardia during hypotensive anesthesia with sodium nitroprusside in orthognathic surgery: a double-blind randomized clinical trial
    Benjamas Apipan
    Department of Surgery, Mahidol University Faculty of Dentistry, Bangkok, Thailand
    J Oral Maxillofac Surg 68:120-4. 2010
    ..with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside could reduce reflex tachycardia, the amount of sodium nitroprusside used, and blood loss during hypotensive anesthesia for orthognathic surgery.
  78. ncbi Giant P waves and focal atrial tachycardia in a patient with ventricular noncompaction
    Yifeng Zhou
    Int J Cardiol 123:210-2. 2008
    A case of ventricular noncompaction with Giant P waves and focal atrial tachycardia is presented. A 36-year-old man was admitted to our hospital because of palpitations and a progressive worsening of heart failure...
  79. pmc Relation between time from myocardial infarction to enrolment and patient outcomes in the Multicenter UnSustained Tachycardia Trial
    Sana M Al-Khatib
    1 Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Europace 12:1112-8. 2010
    ..We sought to assess the relation between time from myocardial infarction (MI) to enrolment and patient outcomes and to examine the association between these outcomes and implantable cardioverter defibrillator (ICD) therapy...
  80. ncbi 8-OH-DPAT prevents cardiac arrhythmias and attenuates tachycardia during social stress in rats
    Eugene Nalivaiko
    School of Biomedical Sciences, Flinders Medical Centre, University of Newcastle, Newcastle, Australia
    Physiol Behav 96:320-7. 2009
    ....
  81. ncbi Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome
    Istvan Bonyhay
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 110:3193-8. 2004
    ..sympathetic nerve function are among the proposed pathophysiological changes in patients with the postural tachycardia syndrome (POTS)...
  82. ncbi Cardiovascular changes of conscious rats after simulated microgravity with and without daily -Gx gravitation
    Li Fan Zhang
    Department of Aerospace Physiology, Fourth Military Medical University, Xi an, China
    J Appl Physiol (1985) 105:1134-45. 2008
    ..Nonlinear measures, but not spectral analysis, might provide promising data to estimate the overall changes in cardiovascular autonomic regulation due to microgravity exposure...
  83. ncbi Ablation of post-surgical intra-atrial reentrant tachycardia. Predilection target sites and mapping approach
    W Anne
    Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Eur Heart J 23:1609-16. 2002
    ..The location of these tachycardias is very diverse due to the individual difference in the original anatomy, surgical corrections, and effects of atrial fibrosis. Nevertheless some recurrent patterns are emerging...
  84. ncbi Continuous progression of orthostatic tachycardia as a further feature of the postural tachycardia syndrome
    Rolf R Diehl
    Autonomic Laboratory, Department of Neurology, Krupp Hospital, Alfried Krupp Strasse 21, 45117 Essen, Germany
    Pacing Clin Electrophysiol 28:975-9. 2005
    The clinical diagnosis of the postural tachycardia syndrome (POTS) includes the demonstration of an upright heart rate (HR) of at least 30 beats per minute (bpm) above supine HR...
  85. pmc Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe
    B C Samuels
    Indiana University School of Medicine, Program in Medical Neurobiology, Indianapolis, IN 46202, USA
    J Physiol 538:941-6. 2002
    ..of neurons in the region of the dorsomedial hypothalamus (DMH) appears to generate the sympathetically mediated tachycardia seen in experimental stress in rats...
  86. ncbi Regional blood volume and peripheral blood flow in postural tachycardia syndrome
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 287:H1319-27. 2004
    Variants of postural tachycardia syndrome (POTS) are associated with increased ["high-flow" POTS (HFP)], decreased ["low-flow" POTS (LFP)], and normal ["normal-flow" POTS (NFP)] blood flow measured in the lower extremities while subjects ..
  87. ncbi Autonomic dysfunction presenting as postural tachycardia syndrome following traumatic brain injury
    Khalil Kanjwal
    Division of Cardiology, Section of Electrophysiology, Department of Medicine, Health Sciences Campus, University of Toledo Medical Center, Toledo, OH, USA
    Cardiol J 17:482-7. 2010
    ..However, until now, postural tachycardia syndrome (POTS) has not been reported as a long-term complication in patients who have suffered a TBI...
  88. ncbi A novel heart failure model induced by sequential coronary artery occlusions and tachycardiac stress in awake pigs
    Y T Shen
    Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Am J Physiol 277:H388-98. 1999
    ..Thus this model could provide a unique opportunity to study both the effects of preclinical therapeutic interventions and the mechanisms involved in the development of heart failure...
  89. ncbi Enalapril, irbesartan, and angiotensin-(1-7) prevent atrial tachycardia-induced ionic remodeling
    Enzhao Liu
    Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People s Republic of China
    Int J Cardiol 146:364-70. 2011
    ..The purpose of this study was to investigate the effects of the ACE inhibitor enalapril, the angiotensin-receptor blocker (ARB) irbesartan, and Ang-(1-7) on the chronic atrial ionic remodeling...
  90. ncbi Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome
    J M Stewart
    Department of Pediatrics, Center for Pediatric Hypotension, New York Medical College, Valhalla, New York 10595, USA
    J Appl Physiol (1985) 89:1505-12. 2000
    Chronic orthostatic intolerance is often related to the postural orthostatic tachycardia syndrome (POTS). POTS is characterized by upright tachycardia...
  91. ncbi Beneficial effects of biatrial pacing on cardiac function in patients with bradycardia -- tachycardia syndrome
    Katsumi Matsumoto
    Second Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
    Circ J 69:831-6. 2005
    ..Biatrial (BiA) pacing prevents atrial fibrillation. By an unknown mechanism. The purpose of this study was to use Doppler echocardiography to evaluate the hemodynamic effects during BiA pacing...
  92. ncbi Failure of corticosteroid therapy to prevent induction of ventricular tachycardia in sarcoidosis
    B Belhassen
    Department of Cardiology, Tel Aviv Medical Center, Ichilov Hospital, Israel
    Chest 95:918-20. 1989
    ..stimulation was performed in a patient with sarcoidosis who exhibited an episode of sustained ventricular tachycardia. Sustained rapid ventricular tachyarrhythmias requiring cardioversion for termination were induced by double ..
  93. ncbi Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1136-42. 2007
    Patients with postural tachycardia syndrome (POTS) have excessive tachycardia without hypotension during orthostasis as well as exercise...
  94. ncbi Effect of short-term microgravity and long-term hindlimb unloading on rat cardiac mass and function
    C A Ray
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Appl Physiol (1985) 91:1207-13. 2001
    ..These data suggest that cardiac atrophy does not occur after short-term exposure to microgravity and that neither short- nor long-term simulated microgravity alters cardiac mass or function...
  95. ncbi Radiofrequency catheter ablation of tachycardia in children with and without congenital heart disease: indications and limitations
    M H Wu
    Department of Pediatrics and Internal Medicine, National Taiwan University Hospital, Taipei
    Int J Cardiol 72:221-7. 2000
    From 1993 to 1998, a total of 100 consecutive pediatric patients with tachycardia (45 male and 55 female, aged 1 year 10 months to 17 years, 11+/-4 year) who underwent electrophysiological study were reviewed...
  96. ncbi Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs
    Jing Quan Zhong
    Cardiology Department, Qilu Hospital of Shandong University, 107 Wen Hua Xi Lu, Jinan 250012, Shandong Province, China
    Eur J Heart Fail 9:23-9. 2007
    To study changes in connexin, metalloproteinase and tissue inhibitor of metalloproteinase levels during tachycardia-induced cardiomyopathy (TIC).
  97. ncbi Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure
    Fadi G Akar
    Johns Hopkins Univ, School of Medicine, 720 Rutland Ave, Ross 844, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 288:H2887-96. 2005
    ..We determined whether downregulation of K(+) currents in a canine model of tachycardia-induced HF is caused by altered expression of underlying K(+) channel alpha- and beta-subunits encoding these ..
  98. ncbi Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 1161 21st Ave South, Nashville, TN 37232 2195, USA
    Circulation 111:2734-40. 2005
    Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance notable for an excessive increase in heart rate that occurs on standing...
  99. ncbi Diagnosis of tachycardia syndromes associated with orthostatic symptoms
    S Braune
    Neurologische Universitatsklinik Freiburg, Germany
    Clin Auton Res 9:97-101. 1999
    The postural tachycardia syndrome (POTS) is characterized by excessive tachycardia only in upright position without evidence of a cardiac or metabolic disease in combination with orthostatic symptoms like dizziness, lightheadedness or ..
  100. ncbi Sustained ventricular tachycardia in long QT syndrome: is propofol the culprit?
    Vimi Rewari
    Anesthesiology 99:764. 2003
  101. ncbi Activation of 5-HT(1A) receptors attenuates tachycardia induced by restraint stress in rats
    Sukonthar Ngampramuan
    Neuro Behavioural Biology Centre, Institute of Science and Technology for Research and Development, Mahidol University, Salaya Nakron Pathom, Thailand
    Am J Physiol Regul Integr Comp Physiol 294:R132-41. 2008
    ..Restraint stress caused tachycardia (an initial transient increase from 318 +/- 3 to 492 +/- 21 beats/min with a sustained component of 379 +/- 12 ..

Research Grants72

  1. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..phenotypes in TS cardiomyocytes: Using a variety of assays I will ask how TS mutation induce lethal ventricular tachycardia and whether TS mutation alters proliferation, differentiation, gene expression, contractility and ultra-..
  2. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..phenotypes in TS cardiomyocytes: Using a variety of assays I will ask how TS mutation induce lethal ventricular tachycardia and whether TS mutation alters proliferation, differentiation, gene expression, contractility and ultra-..
  3. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Sudden cardiac death (SCD) caused by severe arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF), claims the lives of 300,000-400,000 Americans annually...
  4. Purkinje Origin of Ischemic Ventricular Tachycardia and Fibrillation
    James B Martins; Fiscal Year: 2013
    ..This is a remarkably stable model of inducible ventricular tachycardia (VT) and ventricular fibrillation (VF);focal endocardial or Purkinje VT results in half of the experiments and ..
  5. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..Postural tachycardia syndrome (POTS) is the common chronic form of OI...
  6. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..Revascularization therapies and anti-tachycardia devices are available to prevent sudden death, but among the majority of patients who have received these ..
  7. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    ..myofilament Ca2+ sensitivity with EMD57033 in wild-type animals also increased the risk for ventricular tachycardia (VT)...
  8. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    ..USM from knock-in mice of RyR2 R176Q mutation (which causes catecholaminergic polymorphic ventricular tachycardia in human) generates less force when exposed to caffeine, a RyR agonist, and phenylephrine (PE), an alpha1-..
  9. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..of PPAR3, has prolonged QRS and QT intervals, and dies suddenly at 2-8 months of age from ventricular tachycardia (VT). PPAR3 is a ligand-activated transcription factor that regulates lipid and glucose metabolism...
  10. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    ..For example, pain can induce tachycardia, increase myocardial oxygen requirements, and produce cardiac ischemia...
  11. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..of the isolated rabbit heart with optical imaging of the metabolism associated with both regional ischemia and tachycardia, i.e., to create correlative Multimodal Cardiac Imaging (MCI)...
  12. Regulation of Drug Metabolizing Enzyme Ontogeny
    D Gail McCarver; Fiscal Year: 2012
    ..g., sensitivity to ventricular tachycardia in response cisapride therapy) that have resulted from these temporal-specific transitions...
  13. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic orthostatic intolerance takes the form of postural tachycardia syndrome (POTS) in many patients...
  14. Role of Protein Acetylation in Ncx1 Expression
    Donald R Menick; Fiscal Year: 2012
    ..function, and a greater potential for delayed after depolarizations (DADs), with subsequent ventricular tachycardia. Inhibition of exchanger activity or suppression of exchanger upregulation is expected to limit arrhythmias and ..
  15. NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONS
    David Mendelowitz; Fiscal Year: 2013
    ..Acute exposure to hypoxia evokes an initial tachycardia followed by a bradycardia...
  16. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..Myocardial ischemia is both a frequent cause and a consequence of ventricular tachycardia and fibrillation, two potentially lethal forms of cardiac arrhythmia...
  17. Ecstasy and the Dorsomedial Hypothalamus
    Daniel E Rusyniak; Fiscal Year: 2010
    ..Ultimately activation of these systems causes hyperthermia, tachycardia, hypertension, and cutaneous vasoconstriction, effects which are amplified in a warm environment...
  18. Targeted cell therapy for the treatment of ventricular tachycardia
    KENNETH LAURITA; Fiscal Year: 2010
    ..In many patients with chronically healed MI, SCD is due to reentrant ventricular tachycardia (VT) caused by abnormal electrical impulse conduction in the vicinity of scar tissue...
  19. Angiotensin converting enzyme, angiotensin II, and arrhythmia
    Samuel C Dudley; Fiscal Year: 2010
    ..Ventricular pacing readily induced ventricular tachycardia. This phenotype is associated with reductions in cardiac sodium channels...
  20. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    ..production from brown adipose tissue (BAT) thermogenesis, from shivering in skeletal muscle and from a marked tachycardia and increased heat conservation through cutaneous vasoconstriction (CVC)...
  21. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..Pacing-induced tachycardia will be used to produce CHF in dogs;animals will be chronically instrumented for measurement of left ..
  22. Aldosterone and Sodium Regulation in Postural Tachycardia Syndrome
    Satish R Raj; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Postural Tachycardia Syndrome (POTS) is a debilitating clinical condition characterized by intolerance to upright posture of at least 6 months duration, associated with consistent orthostatic ..
  23. Low energy ventricular defibrillator
    Qun Sha; Fiscal Year: 2012
    ..It is often caused by ventricular fibrillation (VF) and ventricular tachycardia (VT). VF is the most frequent mechanism of sudden death...
  24. FKBP Interaction with RYR Calcium Channels in Heart
    Donald M Bers; Fiscal Year: 2013
    ..reticulum (SR) calcium release channel contributes directly to catecholaminergic polymorphic ventricular tachycardia (CPVT) and heart failure (HF) in humans...
  25. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs and TdP...
  26. THAPCA Trials - Scientific Application
    Frank W Moler; Fiscal Year: 2012
    ..Recently, landmark RCTs in adults with OH ventricular fibrillation or tachycardia associated CA and in newborns with birth associated hypoxic ischemic encephalopathy have demonstrated improved ..
  27. Calcineurin's role in circadian regulation of cardiac function and remodeling
    Beverly A Rothermel; Fiscal Year: 2012
    ..In humans, the incidence of adverse cardiac events, such as myocardial infarction, ventricular tachycardia, and death from ischemic heart disease, vary according to the time of day, and forced changes in circadian ..
  28. THAPCA Trials - DCC Application
    JONATHAN MICHAEL DEAN; Fiscal Year: 2013
    ..Recently, landmark RCTs in adults with OH ventricular fibrillation or tachycardia associated CA and in newborns with birth associated hypoxic ischemic encephalopathy have demonstrated improved ..
  29. Autonomic Rare Diseases Clinical Research Consortium
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..atrophy, MSA;(2) pure autonomic failure;(3) autoimmune autonomic gangljonopathy;and (4) hypovolemic postural tachycardia syndrome...
  30. Azithromycin and Sudden Cardiac Death: Electrophysiologic Mechanisms
    Katherine T Murray; Fiscal Year: 2013
    ..Moreover, case reports indicate that while QT prolongation is rarely causative, polymorphic ventricular tachycardia can occur in the absence of ECG abnormalities, implying novel pharmacologic effects, a concept also supported ..
  31. Fundamental Biology of SCD and its Application to Identify Patients at Risk
    GORDON FRANK TOMASELLI; Fiscal Year: 2013
    ..and divided into groups who experience an appropriate ICD firing for rapid symptomatic ventricular tachycardia or ventricular fibrillation, and those who remain free of life-threatening ventricular arrhythmias for a period ..
  32. Calsequestrin in Ventricular Arrhythmia and Sudden Death
    Bjorn C Knollmann; Fiscal Year: 2013
    ..In humans, CASQ2 mutations cause the syndrome of catecholaminergic polymorphic ventricular tachycardia (CPVT) and sudden cardiac death...
  33. Neurobiological Mechanisms of Sympathetic Regulation in Sleep Apnea
    Anne M Fink; Fiscal Year: 2013
    ..g., elevated blood pressure, tachycardia, and increased renal sympathetic nerve activity)...
  34. Structural and Signaling Roles for Cardiac Ankyrin-B
    SHANE CUNHA; Fiscal Year: 2013
    ..that are collectively referred to as "ankyrin-B syndrome" and include catecholamine polymorphic ventricular tachycardia, sinus arrhythmia, atrial fibrillation, and delayed conduction/conduction block...
  35. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..Patients with FD suffer recurrent uncontrollable nausea and vomiting accompanied by skin flushing, tachycardia and arterial hypertension...
  36. Dopamine-B-Hydroxylase in Human Cardiovascular Control
    DAVID HERLIE ROBERTSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Postural tachycardia syndrome (POTS) is the most common form of orthostatic intolerance, affecting an estimated 500,000 Americans, principally young women...
  37. Rational Design of New Drugs to Treat Ventricular Arrhythmias
    Jonathan J Abramson; Fiscal Year: 2012
    ..Treatment options for the termination or suppression of episodes of ventricular tachycardia include implantable cardioverter-defibrillators (ICD), catheter ablation, and anti-arrhythmic drugs...
  38. PHOSPHORYLATION OF GAP JUNCTION PROTEINS
    Paul D Lampe; Fiscal Year: 2013
    ..the role Cx43 regulation plays during fundamental biological processes such as in the heart during ischemia, tachycardia and preconditioning, in skin during wound repair, and in the eye during development...
  39. CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEART
    Sandor Gyorke; Fiscal Year: 2013
    ..RyR2 channel are linked to a broad range of arrhythmias, encompassing catecholaminergic polymorphic ventricular tachycardia (CPVT) and post-infarction sudden cardiac death, which are associated with dysregulated SR Ca release and ..
  40. Late Sodium Current Blockade in High-Risk ICD Patients - DCC
    Arthur J Moss; Fiscal Year: 2013
    ..to a decrease in the number of patients reaching a composite arrhythmia endpoint consisting of ventricular tachycardia or fibrillation requiring appropriate ICD shocks, or death (whichever occurs first)...
  41. The Role of the Transient Outward Current in Genetically Elusive Sudden Death
    John R Giudicessi; Fiscal Year: 2013
    ..SCD), with particular attention to primary channelopathies such as catecholaminergic polymorphic ventricular tachycardia (CPVT), Long-QT Syndrome (LQTS), and Brugada Syndrome (BrS)...
  42. Abstinence and Drug Withdrawal: Innovative Translational Methods for Neonates
    ELISABETH BLOCH SALISBURY; Fiscal Year: 2013
    ..g., bradycardia, tachycardia) and respiration, including decreasing incidents of apnea, periodic breathing and tachypnea;2) Inhibits sleep ..
  43. Molecular Mechanisms of RyR2-triggered Arrhythmias
    Hector H Valdivia; Fiscal Year: 2013
    ..point mutations in the cardiac RyR gene (hRYR2) are associated with Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), an arrhythmogenic syndrome characterized by the development of adrenergically-mediated ventricular ..
  44. Applications of Magnetic Resonance for Management of Ventricular Tachycardia
    Saman Nazarian; Fiscal Year: 2013
    ..in clinical translation of new methodologies for risk stratification and therapy of patients with ventricular tachycardia (VT). My proposed career development plan incorporates patient-oriented research guided by the mentorship of Dr...
  45. Cardiac dysfunction in epilepsy: a candidate mechanism in sudden unexpected death
    Anne E Anderson; Fiscal Year: 2012
    ..Sudden cardiac death resulting from cardiac arrhythmia such as ventricular tachycardia and fibrillation is associated with alterations in cardiac ion channels responsible for the regulation of the ..
  46. Muscle: Excitation/Contraction Coupling Gordon Research Conference
    Paul D Allen; Fiscal Year: 2011
    ..5. Timothy syndrome (Cardiac DHPR). and 5. catecholaminergic polymorphic ventricular tachycardia (RyR2 and Calsequestrin 2)...
  47. Biochemical, Structural and Polymorphic Characterization of Human ALDH1B1
    BRIAN CHRISTOPHER JACKSON; Fiscal Year: 2013
    ..adducts and cellular dysfunction at the molecular level, and acetaldehyde accumulation causes facial flushing, tachycardia, headache and nausea, and alcohol avoidance at the physiological level...
  48. Human Induced Pluripotent Cell Models of Pediatric Cardiac Disorders
    Ihor R Lemischka; Fiscal Year: 2013
    ..hypertrophic cardiomyopathy (HCM) associated with RAS signaling abnormalities and atrial muscle-related tachycardia associated with increased HRAS signaling...
  49. Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRI
    Raymond Y Kwong; Fiscal Year: 2012
    ..PIZCMR contains the structural and electrical substrate essential for the generation of reentrant ventricular tachycardia, and that its healing can be promoted by [unreadable]-3 FA, translating to a reduced risk of SCD and/or ..
  50. Mitigation of the Catecholamine Surge in Severely Burned Patients
    David N Herndon; Fiscal Year: 2013
    ..The hypermetabolic response to burns is also characterized by a profound tachycardia and increased cardiac work that are detrimental to the heart...
  51. Inhibition of NO Dependent Splanchnic Hyperemia Improves CFS/POTS
    ANTHONY JAMES OCON; Fiscal Year: 2012
    Orthostatic intolerance, also known as the postural tachycardia syndrome (POTS), is the most common cause of chronic fatigue syndrome (CFS) in the young...
  52. Novel ion channel approaches to reentrant arrythymias
    Ira S Cohen; Fiscal Year: 2013
    ..is to use our knowledge of the pathophysiology of reentry and of myocardial infarct-associated ventricular tachycardia to hypothesize innovative, mechanism-based approaches to therapy Our general hypothesis is that gene therapy ..
  53. Cardiac Magnetic Resonance IMaging During Arrhythmia
    Aravindan Kolandaivelu; Fiscal Year: 2013
    ..are curable by catheter ablation, some common conditions, in particular atrial fibrillation and ventricular tachycardia (VT), are sub-optimally managed by current medical and ablation treatments...
  54. Climate Change and Cardiac Vulnerability in Humans
    Antonella Zanobetti; Fiscal Year: 2012
    ..multiple pollutant exposures, and cardiovascular (blood pressure, paroxysmal atrial fibrillation, ventricular tachycardia) and cerebrovascular outcomes (stroke) in Eastern Massachusetts, we will partner with the Atmospheric Chemistry ..
  55. Improved Targeting and Assessment of Electrophysiology Intervention
    Henry R Halperin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) and ventricular tachycardia (VT) affect millions of patients in the United States. These arrhythmias can be cured with catheter ablation, but the arrhythmias often recur...
  56. Endovascular Cardiac Optical Mapping
    Christian S Eversull; Fiscal Year: 2013
    ..or identification of focal rotors) Likewise, when performing substrate modification ablation for ventricular tachycardia, identification of ablation targets visually is problematic at best...
  57. Calcium Entrained Arrhythmias
    RAIMOND LESTER WINSLOW; Fiscal Year: 2013
    ..Ca2+) dependent arrhythmias have been identified as a significant health problem leading to ventricular tachycardia, fibrillation and death...
  58. NOVEL CATHETER FOR TREATMENT OF VENTRICULAR TACHYCARDIA
    Michael G Curley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ischemic ventricular tachycardia (VT) is a contributing cause to more than half of the 300,000 sudden cardiac deaths that occur annually in the United States...
  59. Heart and Muscle K+ Channels: Assembly and Regulation
    Gideon Koren; Fiscal Year: 2013
    ..of three Specific Aims: 1) To create and characterize a model of myocardial infarction (MI) and a model of tachycardia induced cardiomyopathy (TICM) in male littermate controls (LMC) and LQT1 rabbits and to characterize of the ..
  60. Differential Approach to the Postural Tachycardia Syndrome
    Wolfgang Singer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Postural Tachycardia Syndrome (POTS) is a disorder of orthostatic tolerance, characterized by excessive tachycardia and symptoms of lightheadedness and faintness when assuming the upright ..
  61. Optical Mapping of the Onset of Ventricular Arrhythmias
    Jack M Rogers; Fiscal Year: 2013
    ..the role of the insertions of the right ventricle in the transition from electrically induced ventricular tachycardia to ventricular fibrillation in failing hearts...
  62. Utilizing Ethyl Nitrate Gas in Laparoscopic Surgery
    James Reynolds; Fiscal Year: 2006
    ..insufflation with CO2 will increase pCOz and decrease blood pH, actions that can produce respiratory acidosis, tachycardia, and arrhythmia...
  63. GENETICS OF ALCOHOLISM IN AMERICAN INDIANS
    Richard Deitrich; Fiscal Year: 1993
    ..Orientals with this gene develop a syndrome following alcohol ingestion with facial flushing, tachycardia and some nausea. While the mutation is common in Oriental populations (approx...
  64. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    ..during pregnancy include chronic increases in cardiac output, falls in total peripheral vascular resistance and tachycardia. There is an upregulation of endothelial nitric oxide synthase in almost all vascular beds studied in the ..
  65. Update and modification of Task Force Criteria for ARVD/C
    Frank Marcus; Fiscal Year: 2007
    ..ventricular arrhythmias originating from the right ventricle including ventricular premature beats, ventricular tachycardia or arrhythmic death. As the disease progresses, right and left heart failure can develop...
  66. ROLE OF PROLONGED REPOLARIZATION IN CARDIAC ARRHYTHMIAS
    Dan Roden; Fiscal Year: 1992
    ..repolarization- prolonging effect of quinidine; under these conditions, a distinctive polymorphic ventricular tachycardia (Torsades de Pointes) developed in patients and early after depolarizations (EADS) were elicited in canine ..
  67. TRH in mediating the bradycardia of caloric restriction
    Steven Swoap; Fiscal Year: 2005
    ..is well established, with increasing attention being paid to the cardiovascular disease risk linked to the tachycardia that is commonly seen in obese patients...
  68. ELECTRODE DESIGN FOR CARDIAC TACHYARRYTHMIA RF ABLATION
    John Webster; Fiscal Year: 2002
    ..The goal of this study is to optimize catheter design for the cure of atrial fibrillation and ventricular tachycardia by endocardial radiofrequency (RF) ablation...
  69. Clonidine Treatment for Neonatal Abstinence Syndrome
    Estelle Gauda; Fiscal Year: 2006
    ..Withdrawal symptoms in newborns include vomiting, diarrhea, poor feeding, tachycardia, hypertension, diaphoresis, restlessness, insomnia, irritability, tremors, clonus, hyperphagia with poor growth ..
  70. Neural Circulatory Control in the Long QT Syndrome
    Virend Somers; Fiscal Year: 2006
    The long QT syndrome (LQTS) is associated with risk for polymorphic ventricular tachycardia, syncope, and sudden death...
  71. FEEDFORWARD CONTROL OF CORONARY BLOOD FLOW
    ERIC FEIGL; Fiscal Year: 1999
    ..as well as elevations in circulating catecholamine levels activate beta-receptors that simultaneously result in tachycardia, increases in myocardial contractility and beta-adrenergic vasodilation of the coronary circulation...