heart diseases

Summary

Top Publications

  1. pmc Anthracycline cardiotoxicity: from bench to bedside
    Luca Gianni
    Division of Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Instituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 26:3777-84. 2008
  2. ncbi Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
    M E R O'Brien
    Kent Cancer Center, Maidstone, UK
    Ann Oncol 15:440-9. 2004
  3. ncbi Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    Giorgio Minotti
    G d Annunzio University School of Medicine, Centro Studi Sull Invecchiamento, Room 412, Via dei Vestini, 66013 Chieti, Italy
    Pharmacol Rev 56:185-229. 2004
  4. ncbi Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
    Manuel D Cerqueira
    American Society of Nuclear Cardiology, USA
    Circulation 105:539-42. 2002
  5. pmc Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
    Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:64. 2012
  6. ncbi Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    Wayne Rosamond
    Circulation 117:e25-146. 2008
  7. ncbi Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries
    Sarah C Darby
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Lancet Oncol 6:557-65. 2005
  8. ncbi Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery
    Jose A Suaya
    Schneider Institutes for Health Policy, Heller School MS 035, Brandeis University, Waltham, MA 02454 9110, USA
    Circulation 116:1653-62. 2007
  9. pmc Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    Erik B Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 13:16. 2011
  10. pmc Cardiac cell repair therapy: a clinical perspective
    Bernard J Gersh
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:876-92. 2009

Detail Information

Publications308 found, 100 shown here

  1. pmc Anthracycline cardiotoxicity: from bench to bedside
    Luca Gianni
    Division of Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Instituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 26:3777-84. 2008
    ..Here, we incorporate these discussions into the framework of a broader review of preclinical and clinical issues...
  2. ncbi Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
    M E R O'Brien
    Kent Cancer Center, Maidstone, UK
    Ann Oncol 15:440-9. 2004
    ....
  3. ncbi Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    Giorgio Minotti
    G d Annunzio University School of Medicine, Centro Studi Sull Invecchiamento, Room 412, Via dei Vestini, 66013 Chieti, Italy
    Pharmacol Rev 56:185-229. 2004
    ..An overview of these issues confirms that anthracyclines remain "evergreen" drugs with broad clinical indications but have still an improvable therapeutic index...
  4. ncbi Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
    Manuel D Cerqueira
    American Society of Nuclear Cardiology, USA
    Circulation 105:539-42. 2002
  5. pmc Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
    Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:64. 2012
    ..We hypothesized that quantitative assessment of myocardial ECV would be clinically useful for detecting both focal and diffuse myocardial abnormalities in a variety of common and uncommon heart diseases.
  6. ncbi Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    Wayne Rosamond
    Circulation 117:e25-146. 2008
  7. ncbi Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries
    Sarah C Darby
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Lancet Oncol 6:557-65. 2005
    ..This study aimed to assess the hazards in the general US population from routine cancer-registry and death-certificate data...
  8. ncbi Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery
    Jose A Suaya
    Schneider Institutes for Health Policy, Heller School MS 035, Brandeis University, Waltham, MA 02454 9110, USA
    Circulation 116:1653-62. 2007
    ..Cardiac rehabilitation (CR) is effective in prolonging survival and reducing disability in patients with coronary heart disease. However, national use patterns and predictors of CR use have not been evaluated thoroughly...
  9. pmc Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    Erik B Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 13:16. 2011
    ..Assuming equivalence between techniques, we further hypothesized that Ve measures would be reproducible across scans...
  10. pmc Cardiac cell repair therapy: a clinical perspective
    Bernard J Gersh
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:876-92. 2009
    ..An interdisciplinary effort across the scientific and clinical community within academia, biotechnology, and government will drive the successful realization of this next generation of therapeutic agents for the "broken" heart...
  11. ncbi The role of cardiovascular magnetic resonance imaging in heart failure
    Theodoros D Karamitsos
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 54:1407-24. 2009
    ..Evidence on the prognostic value of CMR-derived parameters in heart failure is rapidly emerging. This review summarizes the advantages of CMR for patients with heart failure and its important role in key areas...
  12. ncbi Intracellular pH regulation in heart
    Richard D Vaughan-Jones
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, Parks Road, OX1 3PT, UK
    J Mol Cell Cardiol 46:318-31. 2009
    ..Such multiple effects emphasise the fundamental role that pHi regulation plays in the heart...
  13. ncbi Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    Martine J Piccart-Gebhart
    Medicine Department, Jules Bordet Institute, Blvd de Waterloo 125, 1000 Brussels, Belgium
    N Engl J Med 353:1659-72. 2005
    ..We investigated its efficacy and safety after excision of early-stage breast cancer and completion of chemotherapy...
  14. ncbi Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    D J Slamon
    Division of Hematology and Oncology, UCLA School of Medicine, Los Angeles, Calif 90095 1678, USA
    N Engl J Med 344:783-92. 2001
    ..The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30 percent of breast cancers, increasing the aggressiveness of the tumor...
  15. ncbi Endoplasmic reticulum stress as a novel therapeutic target in heart diseases
    Ambrus Toth
    Boston Biomedical Research Institute, Watertown, MA, USA
    Cardiovasc Hematol Disord Drug Targets 7:205-18. 2007
    ..Importantly, suppression of Puma activity prevented both ER stress and ischemia/reperfusion-induced cardiomyocyte loss, highlighting the ER stress pathways as potential therapeutic targets in cardiovascular diseases...
  16. ncbi Crosstalk between autophagy and apoptosis in heart disease
    Kazuhiko Nishida
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Osaka, Japan
    Circ Res 103:343-51. 2008
    ..This review summarizes the evidence for crosstalk between autophagy and apoptosis...
  17. ncbi Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron
    Tomas Simunek
    Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic
    Pharmacol Rep 61:154-71. 2009
    ....
  18. ncbi Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Su
    Charles E Canter
    St Louis Children s Hospital, USA
    Circulation 115:658-76. 2007
    ..These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure...
  19. ncbi Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia
    Steven E Lipshultz
    Department of Pediatrics D820, Miller School of Medicine at the University of Miami, Miami, FL 33101, USA
    J Clin Oncol 23:2629-36. 2005
    ..Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated childhood malignancies. Longitudinal data, however, are rare...
  20. ncbi Drosophila, an emerging model for cardiac disease
    Ethan Bier
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Gene 342:1-11. 2004
    ....
  21. pmc Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort
    Daniel A Mulrooney
    University of Minnesota Medical School and Masonic Cancer Center, Minneapolis, MN 55455, USA
    BMJ 339:b4606. 2009
    ..To assess the incidence of and risks for congestive heart failure, myocardial infarction, pericardial disease, and valvular abnormalities among adult survivors of childhood and adolescent cancers...
  22. pmc Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiography
    Timothy C Wong
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 15:6. 2013
    ..We assessed whether CMR improves outcomes prediction after contemporaneous echo, which may have implications for efforts to optimize processes of care, assess effectiveness, and allocate limited health care resources...
  23. ncbi Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention
    Nicolaus Andratschke
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Munich, Germany
    Radiother Oncol 100:160-6. 2011
    ....
  24. pmc Surgical treatment of cardiac hydatid disease in 13 patients
    Eylem Tuncer
    Department of Cardiovascular Surgery, Kosuyolu Heart and Research Hospital, 34846 Kartal, Istanbul, Turkey
    Tex Heart Inst J 37:189-93. 2010
    ..One patient experienced a recurrence 1 year postoperatively. We discuss our surgical approaches, the outcomes in our patients, and diagnostic and therapeutic recommendations...
  25. ncbi Prospective population-based study of RSV-related intermediate care and intensive care unit admissions in Switzerland over a 4-year period (2001-2005)
    T M Berger
    Children s Hospital of Lucerne, Spitalstrasse, Switzerland
    Infection 37:109-16. 2009
    ..This article reports on all children aged < 3 years who required admission to IMC and/or ICU between October 1, 2001 and September 30, 2005 in Switzerland...
  26. ncbi Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age
    Pyotr G Platonov
    Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden
    J Am Coll Cardiol 58:2225-32. 2011
    ..The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF)...
  27. ncbi Adult stem cells for cardiac tissue engineering
    Eliana C Martinez
    Department of Surgery, National University of Singapore, Singapore, Singapore
    J Mol Cell Cardiol 50:312-9. 2011
    ..This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited"...
  28. pmc Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues
    Yosef A Asiri
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Oxid Med Cell Longev 3:308-16. 2010
    ....
  29. ncbi MicroRNAs in cardiac remodeling and disease
    Zhan Peng Huang
    Cardiovascular Research Division, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA
    J Cardiovasc Transl Res 3:212-8. 2010
    ..In this review, we focus on the recent progress in the understanding of the function of miRNAs in cardiac remodeling and disease. We will also discuss the diagnostic and therapeutic potential of miRNAs in heart disease...
  30. ncbi Liposome-encapsulated doxorubicin in combination with cyclophosphamide, vincristine, prednisone and rituximab in patients with lymphoma and concurrent cardiac diseases or pre-treated with anthracyclines
    Luigi Rigacci
    Department of Hematology, Careggi Hospital and University of Florence, Italy
    Hematol Oncol 25:198-203. 2007
    ....
  31. ncbi Preventing heart disease by controlling hypertension: impact of hypertensive subtype, stage, age, and sex
    Nathan D Wong
    Heart Disease Prevention Program, University of California, Irvine, Calif 92697, USA
    Am Heart J 145:888-95. 2003
    ..Hypertension is related to significant morbidity and mortality rates from coronary heart disease (CHD). This report examines the relative and absolute impact on risk for CHD by controlling hypertension to high normal and optimal levels...
  32. ncbi Cardiac rehabilitation in Europe: results from the European Cardiac Rehabilitation Inventory Survey
    Birna Bjarnason-Wehrens
    Institute for Cardiology and Sports Medicine, German Sport University Cologne, Germany
    Eur J Cardiovasc Prev Rehabil 17:410-8. 2010
    ..Information on CR service delivery in Europe is sketchy...
  33. ncbi Program participation and physical activity maintenance after cardiac rehabilitation
    Beth C Bock
    Miriam Hospital, Center for Behavioral and Preventive Medicine, Brown University School of Medicine, USA
    Behav Modif 27:37-53. 2003
    ..05). Results suggest that Phase III maintenance programs and longer Phase II participation improved exercise maintenance following rehabilitation...
  34. ncbi Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma
    Dawn L Hershman
    Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Clin Oncol 26:3159-65. 2008
    ..We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL)...
  35. pmc Cardiac magnetic resonance imaging in systemic sclerosis: a cross-sectional observational study of 52 patients
    A L Hachulla
    Department of Cardiovascular Radiology, Regional University Hospital, Lille 2 University, Lille, France
    Ann Rheum Dis 68:1878-84. 2009
    ..To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis (SSc)...
  36. ncbi Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane
    Yi Lisa Lyu
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    Cancer Res 67:8839-46. 2007
    ....
  37. ncbi Relationship between retinal arteriolar narrowing and myocardial perfusion: multi-ethnic study of atherosclerosis
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hypertension 51:119-26. 2008
    ..This finding suggests that retinal arteriolar narrowing may serve as a marker of coronary microvascular disease...
  38. ncbi Giving learners the best of both worlds: do clinical teachers need to guard against teaching pattern recognition to novices?
    Tavinder K Ark
    Program for Educational Research and Development, MDCL 3522, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5
    Acad Med 81:405-9. 2006
    ..The purpose of this study was to compare the diagnostic accuracy achieved upon receiving instruction to use each strategy in isolation to that of a combined approach...
  39. ncbi Radiation dose-volume effects in the heart
    Giovanna Gagliardi
    Department of Medical Physics, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
    Int J Radiat Oncol Biol Phys 76:S77-85. 2010
    ..The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury...
  40. ncbi Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary
    M Simons
    Angiogenesis Research Center, BIDMC, Harvard Medical School, Boston, MA, USA
    Circulation 102:E73-86. 2000
    ....
  41. pmc Remodelling of gap junctions and connexin expression in diseased myocardium
    Nicholas J Severs
    National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Cardiovasc Res 80:9-19. 2008
    ....
  42. ncbi Logistic risk model for prolonged ventilation after adult cardiac surgery
    Shekar L C Reddy
    Department of Cardiothoracic Surgery, The Cardiothoracic Centre Liverpool, Liverpool, United Kingdom
    Ann Thorac Surg 84:528-36. 2007
    ..The aim of this study was to develop a multivariate risk prediction model for prolonged ventilation after adult cardiac surgery...
  43. pmc Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro
    Partha Mukhopadhyay
    Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
    Am J Physiol Heart Circ Physiol 296:H1466-83. 2009
    ..Thus, peroxynitrite is a major trigger of DOX-induced cell death both in vivo and in vivo, and the modulation of the pathways leading to its generation or its effective neutralization can be of significant therapeutic benefit...
  44. ncbi Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    N Engl J Med 353:1673-84. 2005
    ..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
  45. pmc MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Clin Invest 117:2369-76. 2007
    ....
  46. pmc Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway
    Wuqiang Zhu
    Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202 5225, USA
    Circulation 119:99-106. 2009
    ..The cardiotoxic effects of doxorubicin are cumulative, which limits its chemotherapeutic dose. Free radical generation and p53-dependent apoptosis are thought to contribute to doxorubicin-induced cardiotoxicity...
  47. pmc Clinical trials for stem cell therapies
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 9107, USA
    BMC Med 9:52. 2011
    ..At the same time, the first three trials using cells derived from pluripotent cells have begun...
  48. ncbi Extension of murine life span by overexpression of catalase targeted to mitochondria
    Samuel E Schriner
    Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
    Science 308:1909-11. 2005
    ..These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals...
  49. ncbi Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice
    Anna Buday
    Institute of Pathophysiology, Dept of Medicine, Semmelweis Univ, Budapest, 1089 Nagyvárad tér 4, Hungary
    Am J Physiol Heart Circ Physiol 299:H386-95. 2010
    ..These findings may provide a mechanism explaining accelerated atherosclerosis in patients with elevated plasma TGFbeta(1)...
  50. ncbi Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial
    P Lechat
    Pharmacology Department, Pitie Salpetriere Hospital, Paris, France
    Circulation 103:1428-33. 2001
    ..beta-Blockade-induced benefit in heart failure (HF) could be related to baseline heart rate and treatment-induced heart rate reduction, but no such relationships have been demonstrated...
  51. ncbi Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
    Heikki Joensuu
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    N Engl J Med 354:809-20. 2006
    ..We compared docetaxel with vinorelbine for the adjuvant treatment of early breast cancer. Women with tumors that overexpressed HER2/neu were also assigned to receive concomitant treatment with trastuzumab or no such treatment...
  52. pmc Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy
    Dirk Westermann
    Department of Cardiology and Pneumology, Charité Universitä tsmedizinBerlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1373-81. 2009
    ..The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the development of experimental diabetic cardiomyopathy...
  53. ncbi S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products
    John H Boyd
    Critical Care Research Laboratories, St Paul Hospital, University of British Columbia, Vancouver, Canada
    Circ Res 102:1239-46. 2008
    ..This finding provides a novel mechanistic link between circulating pathogen-associated molecular products and subsequent cardiac dysfunction...
  54. pmc Autophagy in load-induced heart disease
    Beverly A Rothermel
    Departments of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Circ Res 103:1363-9. 2008
    ..Here, we review recent studies of cardiomyocyte autophagy in load-induced disease and address molecular mechanisms and unanswered questions...
  55. ncbi Molecular and cellular mechanisms of anthracycline cardiotoxicity
    Billy Chen
    Department of Molecular Medicine, Boston University, Boston, TN, USA
    Cardiovasc Toxicol 7:114-21. 2007
    ....
  56. ncbi NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity
    Leszek Wojnowski
    Department of Pharmacology, University Mainz, D 55101 Mainz, Germany
    Circulation 112:3754-62. 2005
    ..There are no data on pharmacogenomic predictors of ACT...
  57. ncbi Evaluation of right ventricular volume and function by 2D and 3D echocardiography compared to MRI
    Jesper Kjaergaard
    Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark
    Eur J Echocardiogr 7:430-8. 2006
    ....
  58. ncbi Predicting sudden death in the population: the Paris Prospective Study I
    X Jouven
    Service de cardiologie, Hopital Boucicaut, Paris, France
    Circulation 99:1978-83. 1999
    ..Therefore, we assessed risk factors, including parental sudden death, associated with the occurrence of sudden death in a long-term cohort study...
  59. ncbi Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure
    R Hambrecht
    University of Leipzig, Heart Center, Department of Internal Medicine Cardiology, Leipzig, Germany
    Circulation 98:2709-15. 1998
    ..Local handgrip exercise has previously been shown to enhance endothelium-dependent vasodilation in conduit and resistance vessels in CHF...
  60. ncbi The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries
    Ravi G Assomull
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London SW3 6NP, UK
    Eur Heart J 28:1242-9. 2007
    ..However, some patients have no coronary obstruction on angiography, leading to diagnostic uncertainty. We evaluated the incremental diagnostic value of cardiovascular magnetic resonance (CMR) in these patients...
  61. ncbi Endogenous cardiac stem cells
    Lucio Barile
    Department of Experimental Medicine, Cenci Bolognetti Foundation, Pasteur Institute, University La Sapienza, Rome, Italy
    Prog Cardiovasc Dis 50:31-48. 2007
    ....
  62. ncbi Caveolins and heart diseases
    Mathivadhani Panneerselvam
    Department of Anesthesiology, University of California, San Diego, CA, USA
    Adv Exp Med Biol 729:145-56. 2012
    ..Furthering our understanding of the role for caveolins in cardiovascular pathophysiology has the potential to lead to the manipulation of caveolins as novel therapeutic targets...
  63. ncbi Gap junction alterations in human cardiac disease
    Nicholas J Severs
    Cardiac Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Cardiovasc Res 62:368-77. 2004
    ....
  64. pmc Stem cell therapy in heart diseases: a review of selected new perspectives, practical considerations and clinical applications
    Eltyeb Abdelwahid
    CBRC, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Curr Cardiol Rev 7:201-12. 2011
    ..We also discuss how research with stem cell transplantation could translate to improvement of cardiac function...
  65. ncbi Quantification of myocardial extracellular volume fraction in systemic AL amyloidosis: an equilibrium contrast cardiovascular magnetic resonance study
    Sanjay M Banypersad
    The Heart Hospital, London, UK
    Circ Cardiovasc Imaging 6:34-9. 2013
    ..We used equilibrium contrast cardiovascular magnetic resonance (EQ-CMR) to quantify the cardiac interstitial compartment, measured as myocardial extracellular volume (ECV) fraction, hypothesizing it would reflect amyloid burden...
  66. ncbi C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Mass 02215, USA
    Circulation 107:391-7. 2003
    ..All of these attributes, however, are associated with increased levels of C-reactive protein (CRP)...
  67. ncbi The roles of microRNAs in heart diseases: a novel important regulator
    B Cai
    Department of Pharmacology, Harbin Medical University, Baojian Road 157, Nangang District, Harbin, Heilongjiang Province 150081, PR China
    Curr Med Chem 17:407-11. 2010
    ..These exciting findings not only improve our understanding of the molecular mechanisms of heart diseases, but also provide a new class of potential molecular targets...
  68. ncbi Cardiac rehabilitation uptake and its determinants in the Netherlands
    Mariëtte van Engen-Verheul
    University of Amsterdam, Amsterdam, The Netherlands
    Eur J Prev Cardiol 20:349-56. 2013
    ..The aims of the present study were to assess CR uptake rates in the Netherlands, and to identify factors that determine uptake...
  69. pmc Spectrum of heart disease associated with murine and human GATA4 mutation
    Satish K Rajagopal
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    J Mol Cell Cardiol 43:677-85. 2007
    ..Additional studies will be required to determine the degree to which GATA4 mutation contributes to human CHD characterized by ECD or RV hypoplasia...
  70. pmc Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
    Douglas B Sawyer
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Prog Cardiovasc Dis 53:105-13. 2010
    ..Moreover, assessing an individual's risk for anthracycline injury may be improved by having some measure of endogenous activity of this and other myocardial protective signals...
  71. ncbi Participating or not in a cardiac rehabilitation programme: factors influencing a patient's decision
    Cedric De Vos
    Deloitte Life Sciences and Healthcare, Brussels, Belgium
    Eur J Prev Cardiol 20:341-8. 2013
    ..The objective of this study was to investigate patient compliance with cardiac rehabilitation and the reasons of refusing or abandoning the programme...
  72. ncbi Late valvular and other cardiac diseases after different doses of mediastinal radiotherapy for Hodgkin disease in children and adolescents: report from the longitudinal GPOH follow-up project of the German-Austrian DAL-HD studies
    Günther Schellong
    Department of Pediatric Hematology and Oncology, University Hospital Munster, Munster, Germany
    Pediatr Blood Cancer 55:1145-52. 2010
    ..To analyze the impact of mediastinal irradiation on the incidence of cardiac late effects in long-term survivors of pediatric Hodgkin disease (HD)...
  73. ncbi Quantitative evaluation of regional left ventricular function using three-dimensional speckle tracking echocardiography in patients with and without heart disease
    Francesco Maffessanti
    University of Chicago, Chicago, Illinois, USA
    Am J Cardiol 104:1755-62. 2009
    ..In conclusion, this is the first study to evaluate the new 3D-STE technique for measurement of regional wall motion indexes. Our findings have demonstrated its superiority over 2D-STE...
  74. ncbi [Retinal vascular signs: a window to the heart?]
    Gerald Liew
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Rev Esp Cardiol 64:515-21. 2011
    ..Retinal photography provides long-lasting records that enable monitoring of longitudinal changes in these retinal signs and vascular health. Full English text available fromwww.revespcardiol.org...
  75. pmc Opposing cardiac effects of autoantibody activation of β-adrenergic and M2 muscarinic receptors in cardiac-related diseases
    Stavros Stavrakis
    Cardiology and the Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma 73104, USA
    Int J Cardiol 148:331-6. 2011
    ..However, the interactions and relative effects of AAβ1AR, AAβ2AR and AAM2R on contractile function have not been characterized...
  76. ncbi 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial
    Ian Smith
    Royal Marsden Hospital, London, UK
    Lancet 369:29-36. 2007
    ..We investigated the drug's effect on overall survival after a median follow-up of 2 years in the Herceptin Adjuvant (HERA) study...
  77. ncbi Standing at the crossroads between new and historically prevalent heart disease: effects of migration and socio-economic factors in the Heart of Soweto cohort study
    Simon Stewart
    Preventative Cardiology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Eur Heart J 32:492-9. 2011
    ..Migration, urbanization, and change in socio-economic factors have potentially profound effects on heart disease in low-to-middle income countries...
  78. ncbi Recombinant human acid alpha-glucosidase enzyme therapy for infantile glycogen storage disease type II: results of a phase I/II clinical trial
    A Amalfitano
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Genet Med 3:132-8. 2001
    ..Further study will be needed to assess the overall potential of this therapy...
  79. ncbi Accuracy of computerized outpatient diagnoses in a Veterans Affairs general medicine clinic
    Herbert C Szeto
    Department of Veterans Affairs, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    Am J Manag Care 8:37-43. 2002
    ....
  80. doi ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline
    Andrew E Epstein
    Circulation 117:e350-408. 2008
  81. ncbi Health-related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices: a prospective, comparative study
    Christiane Kugler
    Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    J Heart Lung Transplant 30:204-10. 2011
    ..The aim of this study was to evaluate and compare health-related quality of life (HRQoL) and physical exercise tolerance in patients after heart transplantation (HTx) or implantation of a left ventricular assist device (LVAD)...
  82. ncbi Cardiotoxicity of cancer therapy
    Justin D Floyd
    University of Missouri Columbia, Ellis Fischel Cancer Center, 115 Business Loop 70 W, Columbia, MO 65203, USA
    J Clin Oncol 23:7685-96. 2005
    ..We review herein the various syndromes of cardiac toxicity that are reported to be associated with antineoplastic agents and discuss their putative mechanisms and treatment...
  83. ncbi Outcome of listing for cardiac transplantation for failed Fontan: a multi-institutional study
    D Bernstein
    Division of Pediatric Cardiology, Stanford University, 750 Welch Rd, Suite 305, Palo Alto, California 94304, USA
    Circulation 114:273-80. 2006
    ..The purpose of this study was to determine risk factors for death awaiting transplantation and to examine results after transplantation in Fontan patients...
  84. ncbi The impact of intra-operative transoesophageal echocardiography on cardiac surgical practice
    A A Klein
    Department of Anaesthesia and Critical Care, Papworth Hospital, Cambridge, UK
    Anaesthesia 64:947-52. 2009
    ..025). In these cases, intra-operative echocardiography was specifically requested by the surgeon to help determine the operative intervention. This has implications for consent and operative risk, which have yet to be fully determined...
  85. ncbi Autophagy in disease: a double-edged sword with therapeutic potential
    Wim Martinet
    Division of Pharmacology, University of Antwerp, B 2610 Antwerp, Belgium
    Clin Sci (Lond) 116:697-712. 2009
    ..Recently, it has been shown that autophagy can be intensified by specific drugs. The pharmacological modulation of the autophagic pathway represents a major challenge for clinicians to treat human disease...
  86. pmc Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease
    Li Qian
    Development and Aging Program, Del E Webb Neuroscience, Aging and Stem Cell Research Center NASCR, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:19833-8. 2008
    ..These findings suggest that the fly heart might serve as an identifier of candidate genes involved in human heart disease...
  87. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Pediatrics 114:1708-33. 2004
    ..Coronary artery aneurysms or ectasia develop in approximately 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death...
  88. ncbi Biomarkers in acute cardiac disease: the present and the future
    Allan S Jaffe
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Medical School, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 48:1-11. 2006
    ..Finally, it reflects on some of the large number of markers that are still in development...
  89. pmc Partial loss of GATA factor Pannier impairs adult heart function in Drosophila
    Li Qian
    NASCR Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Hum Mol Genet 18:3153-63. 2009
    ....
  90. ncbi Myofilament dysfunction in cardiac disease from mice to men
    Nazha Hamdani
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    J Muscle Res Cell Motil 29:189-201. 2008
    ....
  91. ncbi The MacNew heart disease health-related quality of life instrument: reference data for users
    Tracy Dixon
    National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT
    Qual Life Res 11:173-83. 2002
    ..To report reference data for the heart-specific MacNew Heart Disease Health-Related Quality of Life instrument...
  92. ncbi Cardiac regeneration
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Am Coll Cardiol 47:1769-76. 2006
    ..These cell classes hold promise for the treatment of heart failure in humans...
  93. ncbi Predictors of severe stroke: influence of preexisting dementia and cardiac disorders
    Peter Appelros
    Department of Neurology, Orebro University Hospital, Orebro, Sweden
    Stroke 33:2357-62. 2002
    ..We included prestroke dementia, along with other risk factors, to determine independent predictors of stroke severity and early death in a community-based stroke study...
  94. ncbi Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease
    B Schwartzkopff
    Department of Cardiology, Pneumology and Angiology, Heinrich Heine University, Dusseldorf, Germany
    Hypertension 36:220-5. 2000
    ..These findings indicate the beneficial reparative effects of ACE inhibition on coronary microcirculation in hypertensive heart disease...
  95. ncbi Stem cell therapy for heart diseases
    Abdul M Mozid
    Department of Cardiology, The London Chest Hospital, UK
    Br Med Bull 98:143-59. 2011
    ..Left ventricular systolic dysfunction, a major determinant of prognosis, is associated with significant loss of cardiomyocytes which was previously thought to be irreversible as the heart was considered a post-mitotic organ...
  96. ncbi A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats
    Liping Wei
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, China
    Microvasc Res 80:158-65. 2010
    ..PKC-beta inhibitor RBX prevented chronic cardiac microvascular barrier dysfunction and improved endothelial cell-cell junctional function in high glucose states...
  97. ncbi Left ventricular torsion: an expanding role in the analysis of myocardial dysfunction
    Iris K Rüssel
    Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
    JACC Cardiovasc Imaging 2:648-55. 2009
    ..The results obtained over the years are helpful for developing a standardized method to quantify LV torsion and have facilitated the interpretation and value of LV torsion before it can be used as a clinical tool...
  98. ncbi Energy metabolism in the normal and in the diabetic heart
    Antonio Barsotti
    Department of Cardiology, University of Genova, Genova, Italy
    Curr Pharm Des 15:836-40. 2009
    ..In diabetic patients with ischemic heart disease, the effects of modulation of FFA metabolism could even give greater benefit than in nondiabetic patients...
  99. ncbi The developmental genetics of congenital heart disease
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, and Department of Pediatrics, University of California San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nature 451:943-8. 2008
    ..Recent studies have uncovered the genetic basis for some common forms of the disease and provide new insight into how the heart develops and how dysregulation of heart development leads to disease...
  100. ncbi Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task force on the diagnosis and management of pericardial diseases of the European society of cardiology
    Bernhard Maisch
    Department of Internal Medicine Cardiology, Philipps University, Marburg, Germany
    Eur Heart J 25:587-610. 2004
  101. ncbi Cardiac hydatid disease: CT and MRI findings
    Memduh Dursun
    Department of Radiology, Istanbul University, Istanbul Faculty of Medicine, Millet Caddesi, Capa, Istanbul, 34390 Turkey
    AJR Am J Roentgenol 190:226-32. 2008
    ..The purpose of this article is to review the CT and MRI findings of cardiac hydatid disease...

Research Grants64

  1. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..abstract_text> ..
  2. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..The proposed systems to screen a library of compounds to rescue TS phenotypes will provide a platform to find novel lead compounds that would be clinically useful for the treatment of not only TS but also other cardiac arrhythmias. ..
  3. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
    ....
  4. CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE
    Costantino Iadecola; Fiscal Year: 2013
    ..Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition. ..
  5. Regulation of cardiac stress responses by Rho kinase
    Lei Wei; Fiscal Year: 2013
    ....
  6. MAVS protein: A role of mitochondria in innate immunity and cardioprotection
    Kirk Peterson; Fiscal Year: 2013
    ..abstract_text> ..
  7. Phenotypic characterization of nitric oxide regulation of cardiac function by MRI
    Xin Yu; Fiscal Year: 2013
    ..abstract_text> ..
  8. Nuclear lamina in regulation of signaling in muscle
    LARRY R GERACE; Fiscal Year: 2013
    ....
  9. ADP: A Master Regulator for Bioenergetics and Ca2+/ROS Signaling in Heart
    Shey Shing Sheu; Fiscal Year: 2012
    ..The exploratory and high-risk ideas in this application, if validated, will break new ground in a wide spectrum of disease mechanisms and treatments. ..
  10. Effects of K+ Accumulation/Depletion in the Heart
    Guy Salama; Fiscal Year: 2013
    ....
  11. Intracellular Calcium Signaling
    Tobias Meyer; Fiscal Year: 2013
    ..Activation of this signaling system drives T-cell and mast cell responses, contributes to the regulation of myocytes and is linked to a number of human immune and cardiac diseases. ..
  12. Caveolae, T-type Calcium Channels and Cardiac Hypertrophy
    RAVI CHANDRA BALIJEPALLI; Fiscal Year: 2013
    ..Our goal in this study is to identify novel signaling mechanisms and discover key proteins involved in protection against pathological cardiac hypertrophy so effective therapies for disease prevention can be designed. ..
  13. Receptor Na/K-ATPase Antagonists As Novel Therapeutics For Renal/Cardiac Diseases
    Zijian Xie; Fiscal Year: 2013
    ..Moreover, it would provide proof of the concept that antagonists of the receptor Na/K-ATPase can actually reduce renal and cardiac damages. ..
  14. Vascular Risk and Cognition in a Multi-ethnic Cohort
    Clinton B Wright; Fiscal Year: 2013
    ..S., a number equaling the prevalence of forms with dementia. ..
  15. Role of mitochondria in cardiac ischemia
    Peifeng Li; Fiscal Year: 2013
    ..abstract_text> ..
  16. Structural studies of the exocyst
    NEIL VASAN; Fiscal Year: 2011
    ..A structural understanding of the exocyst will help clarify the function of the exocyst in vesicle tethering, and might give insight into the etiologies of these heart and blood diseases. ..
  17. Role of Neuropilin receptors in lymphangiogenesis
    ANNE CHRISTINE EICHMANN; Fiscal Year: 2013
    ..Taken together, this is a comprehensive program aimed at further our understanding of a key biological process, lymphangiogenesis, that may result in development of new therapeutic approaches to prevent lymphedema and cardiac diseases. ..
  18. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
    ..My long-term research interest is improving the therapeutic use of pluripotent stem cells (PSC) for heart diseases. PSC allow gene manipulation and can be differentiated into functional heart muscle cells in the dish...
  19. Immortal DNA Strand and Cardiac Stem Cell Aging
    Piero Anversa; Fiscal Year: 2013
    ..e., non-random DNA template segregation, will have to be determined to characterize the contribution of hCSC growth and differentiation to the development of the old failing heart. ..
  20. Hdac2 and Hopx: Regulators of Cardiac Development
    CHINMAY MAHESHCHANDRA TRIVEDI; Fiscal Year: 2013
    ..Aim 2: Characterize the tissue specific role of Hdac2-Hopx complex in cardiac development through analysis of a newly generated floxed allele of Hdac2. ..
  21. International Gap Junction Conference 2013
    Robert G Gourdie; Fiscal Year: 2013
    ..Additionally the meeting will provide a continuing forum for the fostering of productive collaborations and attracting students and postdoctoral trainees from diverse backgrounds to the gap junction field. ..
  22. FAK signaling in cardiac growth and hypertrophy
    Joan M Taylor; Fiscal Year: 2013
    ..divide, since strategies to manipulate this function could be efficacious in the context of several congenital heart diseases and heart failure...
  23. Arrhythmia Mechanisms in Two Inherited Cardiac Diseases
    JOSE S JALIFE; Fiscal Year: 2012
    ..Accomplishing the work being proposed should provide new insight into fundamental mechanisms leading to complex cardiac rhythms and SCD. ..
  24. Mitochondrial Permeability Transition as a Target for Cardioprotection in Heart F
    Sabzali Javadov; Fiscal Year: 2013
    ..The proposed studies will identify the specific mitochondrial adaptations and alterations, and help develop new therapeutic strategies for treatment of post-myocardial infarction heart failure. ..
  25. Structural Basis of Ventricular Function
    Xin Yu; Fiscal Year: 2010
    ....
  26. In-Vivo Electrophysiology Imaging
    Barry London; Fiscal Year: 2012
    ..If successful, both techniques will increase our understanding of arrhythmia mechanisms, improve risk stratification in patients at risk for sudden death, and guide therapeutic interventions. ..
  27. Three Dimensional Electrocardiographic Imaging
    Bin He; Fiscal Year: 2010
    ....
  28. Identifying novel components of the cardiac necrotic program
    CHRISTOPHER BAINES; Fiscal Year: 2009
    ..Once the key proteins that mediate cell death are identified, they can then be targeted as a means of treating patients with heart disease. ..
  29. Investigation of arrhythmias in anthropomorphized murine cardiac myocytes.
    REBECCA CLARE AHRENS NICKLAS; Fiscal Year: 2010
    ..The new technique proposed in this application will convert the behavior of mouse heart cells to a more human-like state. Studies of mice using this technique should yield new insights into the mechanisms of heart rhythm diseases. ..
  30. Racial and Ethnic Differences in Response to the Medicare Coverage Gap among Pati
    Yuting Zhang; Fiscal Year: 2012
    ....
  31. Regulating human pluripotent stem cell differentiation by colony confinement
    Sean P Palecek; Fiscal Year: 2013
    ....
  32. METHODS FOR THE QUANTIFICATION OF MYOCARDIAL OXYGEN CONSUMPTION WITH 17O MRI
    Jie Zheng; Fiscal Year: 2010
    ..Direct measurement of the oxygen consumption ratio may facilitate comprehensive evaluations of patients with a variety of cardiac diseases. ..
  33. High throughput Electrophysiological Purification Array (HEPA) for cell based the
    John Collins; Fiscal Year: 2013
    ....
  34. 2/3-Multi-Site - Omega-3 for Co-Morbid Depression &HF Treatment (OCEAN)
    David J Whellan; Fiscal Year: 2013
    ....
  35. 3/3-Multi-Site - Omega-3 for Co-Morbid Depression &HF Treatment (OCEAN)
    Kirkwood F Adams; Fiscal Year: 2013
    ....
  36. 1/3-Multi-Site - Omega-3 for Co-Morbid Depression &HF Treatment (OCEAN)
    CHRISTOPHER M O'CONNOR; Fiscal Year: 2013
    ....
  37. The role of C/EBP?? and CITED4 in the heart
    Anthony Rosenzweig; Fiscal Year: 2013
    ..abstract_text> ..
  38. Molecular Identity of the Cardiac Mitochondrial Pore
    CHRISTOPHER PHILIP BAINES; Fiscal Year: 2013
    ..Once the key proteins that mediate cell death are identified, they can then be targeted as a means of treating patients with heart disease. ..
  39. 2007 NIH Director's Pioneer Award Program (DP1)
    MARGARET LISE GARDEL; Fiscal Year: 2011
    ..Finally, this work will impact the treatment of diseases that are a result of misregulation of the physical behaviors of cells, including cancer metastasis and cardiac diseases...
  40. Pathophysiological role of prorenin in CKD
    Alfred K Cheung; Fiscal Year: 2013
    ..This project perfectly aligns with the mission of the NIDDK to study and develop treatments for people with CKD and diabetes. ..
  41. Calcium Triggered Arrhythmias and Sudden Cardiac Arrest
    Richard L Moss; Fiscal Year: 2013
    ..Our uniquely complementary approaches will yield new information concerning genetic and sub-cellular processes that confer increased risk for sudden cardiac arrest in heritable cardiac diseases in humans. ..
  42. Mechanisms and Function of Autophagy in Cancer
    Xuejun Jiang; Fiscal Year: 2013
    ..This study will elucidate the molecular basis of mammalian autophagy and its potential therapeutic role in human cancer. ..
  43. End-to-End Optimization of SPECT Instrumentation, Acquisition, and Reconstruction
    Jonathan M Links; Fiscal Year: 2013
    ..The work will also provide validation of novel optimization strategies using projection-domain ideal-observers that handle mismatch between the imaging model used in the reconstruction and the true imaging process. ..
  44. Characterization of Age-Specific Matrix and Mechanics of Valves
    Elizabeth H Stephens; Fiscal Year: 2010
    ..Such studies are crucial before a successful TEHV can be created. The goals of this proposal are clearly in line with those of the NHLBI to understand the causes and develop interventions for debilitating cardiac diseases. ..
  45. Cardioprotection by optimizing mTOR activity
    MARK ALAN SUSSMAN; Fiscal Year: 2013
    ..Collectively, the studies in this proposal will pave the way for interventional approaches to regulate PRAS40 activity in service to block pathological growth and senescence and improving AKT dependent signaling. ..
  46. Mechanisms for Has2 activation and hyaluronan-mediated cellular invasion
    Evisabel A Craig; Fiscal Year: 2010
    ..With this knowledge we expect to facilitate the development of diagnostic tools and more effective treatment for these cardiac diseases. ..
  47. Nitric oxide signaling in healthy and diseased cardiac myocytes
    Mark T Ziolo; Fiscal Year: 2013
    ..These results may identify new targets for drug development and strategies for the treatment of heart diseases. RELEVANCE (See instructions): Nitric oxide is an important regulator of heart function, the production of ..
  48. IDIOPATHIC DILATED CARDIOMYOPATHY
    Virginia Michels; Fiscal Year: 1991
    ..Identification of the sources of variability of ANP levels and echocardiographic variables of cardiac structure and function will be relevant for cardiac diseases other than IDC...
  49. Genetic Studies of Sarcomere-based Cardiac Diseases
    Xiaolei Xu; Fiscal Year: 2013
    ....
  50. Electrical and mechanical behavior of live human myocardium in health and disease
    PAULUS ML JANSSEN; Fiscal Year: 2010
    ....
  51. MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIAS
    Guy Salama; Fiscal Year: 2002
    ..abstract_text> ..
  52. BLOOD PRESSURE CONTROL IN EXPERIMENTAL HEART DISEASE
    NICHOLAS OLIVIER; Fiscal Year: 1991
    ..This research is important because impairment of normal baroreflex function is likely to contribute to the instability of blood pressure, cardiac output, and total peripheral resistance that frequently complicated cardiac disease...
  53. Induction of Cellular Antioxidants and Cardioprotection
    Yunbo Li; Fiscal Year: 2006
    ..and the protective role of the D3T-induced cellular antioxidant defenses in oxidative cardiac injury _caused not only by doxorubicin but also by other pathophysiological processes, such as ischemia-reperfusion [unreadable] [unreadable]..
  54. SIGNALS OF OXIDANT INDUCED CARDIOMYOCYTE HYPERTROPHY
    Qin Chen; Fiscal Year: 1999
    ..We propose to study the mechanism of oxidant stress by novel and innovative approaches. The results will contribute to the understanding of the process of heart aging and the pathogenesis of heart failure. ..
  55. MOLECULAR CHARACTERIZATION OF MCLI PCNA INTERACTION
    Kenichi Fujise; Fiscal Year: 2003
    ..Fujise will be an independent, highly productive investigator with a high likelihood of making critical contributions in the fieled of apoptosis regulations and in prevention and treatment of cardiac diseases. ..
  56. Cytoskeletal Basis of Ventricular Arrhythmias
    Matteo Vatta; Fiscal Year: 2005
    ..Identifying cytoskeletal mecahnisms involved in malignant arrhythmias, could lead to the design of novel drugs and the employment of therapeutic means, resulting in a better patients management. ..
  57. INDUCIBLE NO SYNTHASE IN CARDIAC ALLOGRAFT REJECTION
    PAUL CANNON; Fiscal Year: 2002
    ....
  58. Transcriptional remodeling in cardiac arrhythmias
    ALFRED GEORGE; Fiscal Year: 2005
    ..These studies will provide new insights into the pathogenesis of arrhythmia susceptibility and contribute to identifying potential new targets for therapeutic interventions. ..
  59. Improved Methods for Myocardial Gene Transfer
    J Donahue; Fiscal Year: 2005
    ..Successful completion of these aims will bring gene therapy one-step closer to realizing its potential as a cardiovascular therapeutic. ..
  60. Multipotent heart cell progenitor lineages in cardiac development and disease
    Kenneth Chien; Fiscal Year: 2009
    ..5 progenitors and their cardiomyogenic lineages derived from ES and iPS cells;3) Generation and characterization of murine and human heart muscle strips from ES and iPS cells that harbor cardiomyopathic mutations. . ..
  61. CARDIAC REGULATORY MECHANISMS
    Steven Houser; Fiscal Year: 2004
    ..All sessions will include late breaking science (from poster contributions) and as always, there will be ample time for poster sessions and informal interchange. ..
  62. Development and study of specific Kir channel inhibitors
    Zhe Lu; Fiscal Year: 2009
    ..abstract_text> ..
  63. IMPROVED CINE MRI BY DIRECT-INVERSION RECONSTRUCTION
    Marijn Brummer; Fiscal Year: 2009
    ..Qualitative and quantitative evaluations will be performed of image quality and flow calculations using the method. Finally, feasibility will be investigated of combining this method and parallel imaging methods. ..
  64. 2006 CARDIAC REGULATORY MECHANISMS GORDON CONFERENCE
    KENNETH PHILIPSON; Fiscal Year: 2006
    ..All sessions will include late breaking science (from poster contributions) and as always, there will be ample time for poster sessions and informal interchange of ideas. [unreadable] [unreadable] [unreadable] [unreadable]..