tetralogy of fallot

Summary

Summary: A combination of congenital cardiac defects consisting of pulmonary stenosis, interventricular septal defects, dextroposition of the aorta so that it overrides the interventricular septum and receives venous as well as arterial blood, and right ventricular hypertrophy.

Top Publications

  1. ncbi Variability in surgical referral patterns for pulmonary valve replacement in adults with repaired tetralogy of fallot
    Rachel M Wald
    Toronto General Hospital Toronto Congenital Cardiac Centre for Adults, University of Toronto, Toronto, Ontario, Canada
    Congenit Heart Dis 4:231-8. 2009
  2. ncbi Tetralogy of fallot: 3D velocity-encoded MR imaging for evaluation of right ventricular valve flow and diastolic function in patients after correction
    Annelies E van der Hulst
    Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Center, RC, Leiden, The Netherlands
    Radiology 256:724-34. 2010
  3. pmc De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot
    Steven C Greenway
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 41:931-5. 2009
  4. pmc Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls
    Rachel Soemedi
    Institute of Genetic Medicine, Newcastle University, Newcastle, UK
    Hum Mol Genet 21:1513-20. 2012
  5. ncbi Noncoding RNA expression in myocardium from infants with tetralogy of Fallot
    James E O'Brien
    Section of Cardiovascular and Thoracic Surgery, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Circ Cardiovasc Genet 5:279-86. 2012
  6. ncbi Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot
    Antonio Pizzuti
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Rome, Italy
    Hum Mutat 22:372-7. 2003
  7. pmc Rare copy number variations in adults with tetralogy of Fallot implicate novel risk gene pathways
    Candice K Silversides
    Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    PLoS Genet 8:e1002843. 2012
  8. ncbi NKX2.5 mutations in patients with tetralogy of fallot
    E Goldmuntz
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA
    Circulation 104:2565-8. 2001
  9. pmc Quantification of biventricular myocardial function using cardiac magnetic resonance feature tracking, endocardial border delineation and echocardiographic speckle tracking in patients with repaired tetralogy of Fallot and healthy controls
    Aleksander Kempny
    Adult Congenital and Valvular Heart Disease Center, Department of Cardiology and Angiology, University Hospital of Muenster, Albert Schweitzer Str, 33, 48149, Munster, Germany
    J Cardiovasc Magn Reson 14:32. 2012
  10. pmc Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis
    Robert C Bauer
    Department of Pediatrics, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Hum Mutat 31:594-601. 2010

Detail Information

Publications338 found, 100 shown here

  1. ncbi Variability in surgical referral patterns for pulmonary valve replacement in adults with repaired tetralogy of fallot
    Rachel M Wald
    Toronto General Hospital Toronto Congenital Cardiac Centre for Adults, University of Toronto, Toronto, Ontario, Canada
    Congenit Heart Dis 4:231-8. 2009
    Individuals with repaired tetralogy of Fallot (TOF) comprise a substantial proportion of the current adult congenital heart disease population...
  2. ncbi Tetralogy of fallot: 3D velocity-encoded MR imaging for evaluation of right ventricular valve flow and diastolic function in patients after correction
    Annelies E van der Hulst
    Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Center, RC, Leiden, The Netherlands
    Radiology 256:724-34. 2010
    ..2D) VE MR imaging, for assessment of pulmonary valve (PV) and tricuspid valve (TV) flow, with planimetry as the reference standard, and to evaluate diastolic function in patients with a corrected tetralogy of Fallot (TOF).
  3. pmc De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot
    Steven C Greenway
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 41:931-5. 2009
    b>Tetralogy of Fallot (TOF), the most common severe congenital heart malformation, occurs sporadically, without other anomaly, and from unknown cause in 70% of cases...
  4. pmc Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls
    Rachel Soemedi
    Institute of Genetic Medicine, Newcastle University, Newcastle, UK
    Hum Mol Genet 21:1513-20. 2012
    ..We examined the 1q21.1 locus in 948 patients with tetralogy of Fallot (TOF), 1488 patients with other forms of CHD and 6760 ethnically matched controls using single nucleotide ..
  5. ncbi Noncoding RNA expression in myocardium from infants with tetralogy of Fallot
    James E O'Brien
    Section of Cardiovascular and Thoracic Surgery, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Circ Cardiovasc Genet 5:279-86. 2012
    ....
  6. ncbi Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot
    Antonio Pizzuti
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Rome, Italy
    Hum Mutat 22:372-7. 2003
    Two out of 47 patients with sporadic tetralogy of Fallot (TOF), the most common cyanotic conotruncal heart defect (CTD), showed heterozygous missense mutations of the ZFPM2/FOG2 gene...
  7. pmc Rare copy number variations in adults with tetralogy of Fallot implicate novel risk gene pathways
    Candice K Silversides
    Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
    PLoS Genet 8:e1002843. 2012
    ..b>Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease, but to date little is known about the ..
  8. ncbi NKX2.5 mutations in patients with tetralogy of fallot
    E Goldmuntz
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA
    Circulation 104:2565-8. 2001
    Recent reports have implicated mutations in the transcription factor NKX2.5 as a cause of tetralogy of Fallot (TOF). To estimate the frequency of NKX2...
  9. pmc Quantification of biventricular myocardial function using cardiac magnetic resonance feature tracking, endocardial border delineation and echocardiographic speckle tracking in patients with repaired tetralogy of Fallot and healthy controls
    Aleksander Kempny
    Adult Congenital and Valvular Heart Disease Center, Department of Cardiology and Angiology, University Hospital of Muenster, Albert Schweitzer Str, 33, 48149, Munster, Germany
    J Cardiovasc Magn Reson 14:32. 2012
    ..have been suggested to be superior to conventional measures of ventricular function in patients with tetralogy of Fallot (ToF), but have required non-routine, tagged cardiovascular magnetic resonance (CMR) techniques...
  10. pmc Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis
    Robert C Bauer
    Department of Pediatrics, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Hum Mutat 31:594-601. 2010
    ..in cases with right-sided cardiac defects not otherwise diagnosed with AGS, we screened 94 cases with tetralogy of Fallot (TOF) and 50 with pulmonic stenosis/peripheral pulmonary stenosis (PS/PPS) or pulmonary valve atresia with ..
  11. pmc Repaired tetralogy of Fallot: the roles of cardiovascular magnetic resonance in evaluating pathophysiology and for pulmonary valve replacement decision support
    Tal Geva
    Department of Cardiology, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    J Cardiovasc Magn Reson 13:9. 2011
    Surgical management of tetralogy of Fallot (TOF) results in anatomic and functional abnormalities in the majority of patients...
  12. ncbi New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle
    Alessandro De Luca
    CSS Mendel Institute, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Rome, Italy
    Clin Genet 80:184-90. 2011
    ..5, ZFPM2/FOG2, GDF1, and ISLET1 gene mutations in a large cohort of individuals with CTD, including tetralogy of Fallot with or without pulmonary atresia (TOF, 178 patients), double outlet right ventricle (DORV, 13 patients), ..
  13. ncbi Familial Tetralogy of Fallot caused by mutation in the jagged1 gene
    Z A Eldadah
    Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Mol Genet 10:163-9. 2001
    b>Tetralogy of Fallot (ToF) is the most common form of complex congenital heart disease, occurring in approximately 1 in 3000 live births...
  14. pmc Systematic survey of variants in TBX1 in non-syndromic tetralogy of Fallot identifies a novel 57 base pair deletion that reduces transcriptional activity but finds no evidence for association with common variants
    Helen R Griffin
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Heart 96:1651-5. 2010
    b>Tetralogy of Fallot (TOF) is common in individuals with hemizygous deletions of chromosome 22q11.2 that remove the cardiac transcription factor TBX1.
  15. ncbi Pulmonary regurgitation is an important determinant of right ventricular contractile dysfunction in patients with surgically repaired tetralogy of Fallot
    A Frigiola
    Grown up Congenital Heart Unit, The Heart Hospital, Westmoreland Street, London, UK
    Circulation 110:II153-7. 2004
    ..Evaluation of right ventricular (RV) function in patients with pulmonary regurgitation (PR) after tetralogy repair remains challenging because of abnormal RV loading conditions...
  16. ncbi A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect
    Xiaoping Lin
    Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai, PR China
    J Hum Genet 55:662-7. 2010
    ..The same heterozygous missense mutation (Ser184Asn) was identified in three patients, including one with tetralogy of Fallot and two with atrial septal defects...
  17. pmc Gene expression in cardiac tissues from infants with idiopathic conotruncal defects
    Douglas C Bittel
    Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, USA
    BMC Med Genomics 4:1. 2011
    b>Tetralogy of Fallot (TOF) is the most commonly observed conotruncal congenital heart defect...
  18. ncbi A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot
    Georges Nemer
    Department of Biochemistry, American University of Beirut, Beirut, Lebanon
    Hum Mutat 27:293-4. 2006
    ..This mutation was found in two out of 26 patients with Tetralogy of Fallot (TOF), and in none of the 94 patients with different phenotypes included in the study, nor in 223 healthy ..
  19. ncbi Tetralogy of Fallot
    Christian Apitz
    Division of Cardiology, Labatt Family Heart Centre, Hospital for Sick Children, Toronto, ON, Canada
    Lancet 374:1462-71. 2009
    b>Tetralogy of Fallot is the most common form of cyanotic congenital heart disease, and one of the first to be successfully repaired by congenital heart surgeons...
  20. pmc 4D cardiovascular magnetic resonance velocity mapping of alterations of right heart flow patterns and main pulmonary artery hemodynamics in tetralogy of Fallot
    Christopher J Francois
    Departments of Radiology, University of Wisconsin Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53562, USA
    J Cardiovasc Magn Reson 14:16. 2012
    To assess changes in right heart flow and pulmonary artery hemodynamics in patients with repaired Tetralogy of Fallot (rTOF) we used whole heart, four dimensional (4D) velocity mapping (VM) cardiovascular magnetic resonance (CMR).
  21. ncbi Comparison of accuracy of axial slices versus short-axis slices for measuring ventricular volumes by cardiac magnetic resonance in patients with corrected tetralogy of fallot
    Sohrab Fratz
    Department of Paediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München an der Technischen Universität München, Munich, Germany
    Am J Cardiol 103:1764-9. 2009
    The best method to measure right (RV) and left (LV) ventricle volumes of patients with corrected tetralogy of Fallot is considered cardiac magnetic resonance (CMR)...
  22. pmc Novel GATA6 mutations associated with congenital ventricular septal defect or tetralogy of fallot
    Juan Wang
    Department of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China
    DNA Cell Biol 31:1610-7. 2012
    ..D404Y and p.E460X, were identified in two families with ventricular septal defect and tetralogy of Fallot, respectively...
  23. pmc Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot
    Heather J Cordell
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hum Mol Genet 22:1473-81. 2013
    We conducted a genome-wide association study to search for risk alleles associated with Tetralogy of Fallot (TOF), using a northern European discovery set of 835 cases and 5159 controls. A region on chromosome 12q24 was associated (P = 1...
  24. pmc A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot
    Valentina Guida
    Mendel Laboratory, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Eur J Hum Genet 21:69-75. 2013
    ..Pro265Ser mutant disrupts overall morphology of the heart tube in the 37% (22/60) of embryos, compared with the 6% (4/66) of the GJA5 wild-type-injected embryos. These findings implicate GJA5 gene as a novel susceptibility gene for TOF...
  25. ncbi A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot
    Judith A Goodship
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Circ Cardiovasc Genet 5:287-92. 2012
    b>Tetralogy of Fallot (TOF) is the commonest cyanotic form of congenital heart disease. In 80% of cases, TOF behaves as a complex genetic condition exhibiting significant heritability...
  26. ncbi Tetralogy of fallot as a model to study cardiac progenitor cell migration and differentiation during heart development
    Valentina Di Felice
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Palermo, Italy
    Trends Cardiovasc Med 19:130-5. 2009
    b>Tetralogy of Fallot (ToF) has long been considered a congenital disorder that occurs due to environmental alterations during gestation...
  27. pmc Patterns of cardiac and extracardiac anomalies in adults with tetralogy of fallot
    Sara Piran
    Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Division of Cardiology, University of Toronto, Toronto, Canada
    Am Heart J 161:131-7. 2011
    b>tetralogy of Fallot (TOF) is a complex congenital heart disease with clinical and genetic heterogeneity. Of the few known causes, 22q11.2 deletion syndrome (22q11DS) is the most common...
  28. ncbi Follow-up after pulmonary valve replacement in adults with tetralogy of Fallot: association between QRS duration and outcome
    Roderick W C Scherptong
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 56:1486-92. 2010
    The aim of this study was to analyze whether QRS duration, before and after pulmonary valve replacement (PVR), is related to long-term outcome in patients with tetralogy of Fallot (TOF).
  29. ncbi Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance
    Thomas Oosterhof
    Academic Medical Center, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 116:545-51. 2007
    ..To facilitate the optimal timing of pulmonary valve replacement, we analyzed preoperative thresholds of right ventricular (RV) volumes above which no decrease or normalization of RV size takes place after surgery...
  30. ncbi Long-term survival in patients with repair of tetralogy of Fallot: 36-year follow-up of 490 survivors of the first year after surgical repair
    G Nollert
    Clinic of Cardiac Surgery, Klinikum Grosshadern, University of Munich, Germany
    J Am Coll Cardiol 30:1374-83. 1997
    We sought to analyze risk factors for long-term survival (up to 36 years) after surgical repair of tetralogy of Fallot (TOF).
  31. ncbi NKX2.5 mutations in patients with congenital heart disease
    Doff B McElhinney
    The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 42:1650-5. 2003
    ..The purpose of this study was to estimate the frequency of NKX2.5 mutations in specific cardiovascular anomalies and investigate genotype-phenotype correlations in individuals with NKX2.5 mutations...
  32. ncbi Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair
    Judith Therrien
    Toronto Congenital Cardiac Centre for Adults, Toronto, Ontario, Canada
    Am J Cardiol 95:779-82. 2005
    The timing of pulmonary valve replacement in adult patients with repaired tetralogy of Fallot remains controversial...
  33. ncbi Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study
    M A Gatzoulis
    Department of Paediatrics, Royal Brompton Hospital and the National Heart and Lung Institute, London, UK
    Lancet 356:975-81. 2000
    Ventricular arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot are devastating complications in adult survivors of early surgery, but their prediction remains difficult.
  34. ncbi Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of fallot and its relationship to adverse markers of clinical outcome
    Sonya V Babu-Narayan
    Adult Congenital Heart Unit, Royal Brompton Hospital, London SW3 6NP, United Kingdom
    Circulation 113:405-13. 2006
    Late morbidity and mortality remain problematic after repair of tetralogy of Fallot (TOF)...
  35. ncbi Tei index determined by tissue Doppler imaging in patients with pulmonary regurgitation after repair of tetralogy of Fallot
    K Yasuoka
    Departments of Pediatrics and Cardiovascular Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Pediatr Cardiol 25:131-6. 2004
    ..We examined 15 patients (6.3 +/- 2.2 years) with significant PR after repair of tetralogy of Fallot (TOF) and 24 age-matched healthy children...
  36. pmc Reproducibility of MRI measurements of right ventricular size and function in patients with normal and dilated ventricles
    Christiaan F Mooij
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    J Magn Reson Imaging 28:67-73. 2008
    ..To determine the inter- and intraobserver reproducibility of cardiac magnetic resonance (CMR)-derived measurements of right ventricular (RV) mass, volume, and function in patients with normal and dilated ventricles...
  37. ncbi Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging
    Tal Geva
    Department of Cardiology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Coll Cardiol 43:1068-74. 2004
    The purpose of this study was to identify independent factors associated with impaired clinical status in late survivors of tetralogy of Fallot (TOF) repair.
  38. ncbi Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair
    A L Knauth
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart 94:211-6. 2008
    Factors associated with impaired clinical status in a cross-sectional study of patients with repaired tetralogy of Fallot (TOF) have been reported previously.
  39. ncbi Pulmonary regurgitation: not a benign lesion
    Beatriz Bouzas
    Adult Congenital Heart Centre, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 26:433-9. 2005
    ..a common complication after surgical or percutaneous relief of pulmonary stenosis and following repair of tetralogy of Fallot. Significant PR is usually well tolerated in childhood...
  40. ncbi The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot
    Cláudia Marinho
    Laboratorio de Genetica, Faculdade de Medicina de Lisboa, Lisboa, Portugal
    Rev Port Cardiol 28:809-12. 2009
    ..which has been associated with neural tube defects and congenital oral cleft, is also associated with tetralogy of Fallot (TF), a congenital heart disease...
  41. ncbi Global impairment of cardiac autonomic nervous activity late after repair of tetralogy of Fallot
    Constantinos H Davos
    Royal Brompton Adult Congenital Heart Program, the Department of Clinical Cardiology, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 106:I69-75. 2002
    ..tachycardia (VT) and sudden cardiac death (SCD) remain devastating late complications after repair of Tetralogy of Fallot (ToF)...
  42. ncbi Usefulness of post-ventriculotomy signal averaged electrocardiograms in congenital heart disease
    Joseph K Perloff
    Ahmanson UCLA Adult Congenital Heart Disease Center and Division of Cardiology, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Am J Cardiol 98:1646-51. 2006
    ....
  43. pmc Controlled reoxygenation cardiopulmonary bypass is associated with reduced transcriptomic changes in cyanotic tetralogy of Fallot patients undergoing surgery
    Mohamed T Ghorbel
    Bristol Heart Institute, School of Clinical Science, University of Bristol, Bristol, United Kingdom
    Physiol Genomics 44:1098-106. 2012
    ..CPB on gene expression changes in cyanotic hearts of patients undergoing surgical correction of tetralogy of Fallot (TOF)...
  44. ncbi Tetralogy of fallot: yesterday and today
    Joanne P Starr
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, 07103, USA
    World J Surg 34:658-68. 2010
    b>Tetralogy of Fallot (TOF) is a cyanotic congenital cardiac defect that was first described by Stenson in 1672 and later named for Fallot, who in 1888 described it as a single pathological process responsible for (1) pulmonary outflow ..
  45. ncbi Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction
    Periklis A Davlouros
    Department of Cardiology, Royal Brompton Hospital, London, United Kingdom
    J Am Coll Cardiol 40:2044-52. 2002
    ..among biventricular hemodynamics, pulmonary regurgitant fraction (PRF), right ventricular outflow tract (RVOT) aneurysm or akinesia, and baseline and surgical characteristics in adults with repaired tetralogy of Fallot (rTOF).
  46. pmc LINE-1 methylation status and its association with tetralogy of fallot in infants
    Wei Sheng
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
    BMC Med Genomics 5:20. 2012
    ..To derive insight into the association between genome-wide methylation status and tetralogy of fallot (TOF), we compared the methylation status of LINE-1 element between TOF patients and controls...
  47. ncbi Exercise capacity and ventricular function in patients treated for isolated pulmonary valve stenosis or tetralogy of Fallot
    Saskia E Luijnenburg
    Department of Pediatrics, Division of Cardiology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Int J Cardiol 158:359-63. 2012
    ..valve stenosis (PS) treated with balloon pulmonary valvuloplasty (BPV) than in patients operated for tetralogy of Fallot (TOF), and 2) that ventricular outcome and exercise capacity would not be different in PS patients and ..
  48. ncbi Tetralogy of Fallot: impact of the excursion of the interventricular septum on left ventricular systolic function and fibrosis after surgical repair
    Stefano Muzzarelli
    Department of Radiology, University Hospital of California San Francisco, 505 Parnassus Ave, Box 0628, Room L 325A, San Francisco, CA 94143 0628, USA
    Radiology 259:375-83. 2011
    To quantify the excursion of interventricular septum (IVS) in patients after repair of tetralogy of Fallot (TOF), a marker of interventricular interaction, and assess its association with left ventricular (LV) ejection fraction, LV ..
  49. pmc Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot
    Liang Zhong
    Cardiac Mechanics Engineering and Physiology Unit, National Heart Centre Singapore, Singapore
    Am J Physiol Heart Circ Physiol 302:H1306-16. 2012
    A quantitative understanding of right ventricular (RV) remodeling in repaired tetralogy of Fallot (rTOF) is crucial for patient management...
  50. ncbi Children and adolescents with repaired tetralogy of fallot report quality of life similar to healthy peers
    Elena N Kwon
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Congenit Heart Dis 6:18-27. 2011
    The study aims to evaluate and compare self-reported and parent proxy-reported quality of life (QOL) in pediatric patients with repaired tetralogy of Fallot (TOF) and determine relationships with residual disease.
  51. ncbi Left ventricular torsion and strain in patients with repaired tetralogy of Fallot assessed by speckle tracking imaging
    Hirobumi Takayasu
    Department of Pediatrics, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Echocardiography 28:720-9. 2011
    In patients with tetralogy of Fallot (TOF), left ventricular (LV) dysfunction is an important factor associated with poor clinical outcome.
  52. ncbi Three-dimensional shape analysis of right ventricular remodeling in repaired tetralogy of Fallot
    Florence H Sheehan
    University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:107-13. 2008
    ..We imaged 15 patients with repaired tetralogy of Fallot (TOF) and 8 normal subjects by magnetic resonance imaging in long- and short-axis views...
  53. ncbi Changes in QRS duration are associated with maximal exercise capacity in adult patients with repaired tetralogy of Fallot
    W Budts
    Internal Medicine, Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Cardiol 104:46-51. 2005
    In adult patients with repaired tetralogy of Fallot (TF) QRS duration at rest seems to be a predictor of maximal exercise. We examined the relationship between QRS duration during exercise and exercise performance.
  54. ncbi Structural abnormalities of the pulmonary trunk in tetralogy of Fallot and potential clinical implications: a morphological study
    Elisabeth Bedard
    Adult Congenital Heart Centre Centre for Pulmonary Hypertension and Unit of Cardiac Morphology, Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 54:1883-90. 2009
    ..The purpose of this study was to determine whether intrinsic histological abnormalities of the pulmonary trunk (PT) are present from birth and interact with palliative surgery and/or repair...
  55. ncbi Genome-wide array analysis of normal and malformed human hearts
    Bogac Kaynak
    Department of Vertebrate Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Circulation 107:2467-74. 2003
    ..As a consequence of the malformation, abnormal hemodynamic features occur and cause an adaptation process of the heart...
  56. ncbi Changes during exercise of ECG intervals related to increased risk for ventricular arrhythmia in repaired tetralogy of Fallot and their relationship to right ventricular size and function
    Jochem van den Berg
    Department of Paediatric Cardiology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Int J Cardiol 124:332-8. 2008
    Our study aimed to assess pro-arrhythmogenic electrocardiographic changes during maximal physical exercise in patients operated for Tetralogy of Fallot (TOF).
  57. ncbi Somatic mutations in the GATA6 gene underlie sporadic tetralogy of Fallot
    Ri Tai Huang
    Department of Cardiothoracic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, PR China
    Int J Mol Med 31:51-8. 2013
    b>Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease associated with significant morbidity and mortality in humans...
  58. ncbi Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects
    Haruka Hamanoue
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Cardiol Young 19:482-5. 2009
    ..patients in Indonesia with congenitally malformed hearts, 76 cases having atrial septal defect and 28 tetralogy of Fallot. We found only 1 novel mutation of GATA4 in those with atrial septal defects...
  59. pmc Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan's syndrome
    Candice K Silversides
    Toronto Congenital Cardiac Centre for Adults, University of Toronto, Ontario
    Can J Cardiol 26:e80-97. 2010
    ..and bicuspid aortic valve disease, coarctation of the aorta, right ventricular outflow tract obstruction, tetralogy of Fallot, Ebstein anomaly and Marfan's syndrome...
  60. pmc GATA4 sequence variants in patients with congenital heart disease
    A Tomita-Mitchell
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Med Genet 44:779-83. 2007
    ..Given that patients with septal and conotruncal defect can share a common genetic basis, it is unclear whether patients with additional types of CHD might also have GATA4 mutations...
  61. ncbi Pulmonary valve replacement in tetralogy of Fallot improves the repolarization
    Bart Hooft van Huysduynen
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Int J Cardiol 124:301-6. 2008
    To assess the effect of pulmonary valve replacement (PVR) on the repolarization of patients with tetralogy of Fallot.
  62. pmc Tetralogy of Fallot: from fetus to adult
    Elliot A Shinebourne
    Department Paediatric Cardiology, Royal Brompton Hospital, London, UK
    Heart 92:1353-9. 2006
  63. ncbi Right ventricular outflow tract reconstruction for pulmonary regurgitation after repair of tetralogy of Fallot. Preliminary results
    Olivier Ghez
    Great Ormond Street Hospital for Children, The Heart Hospital, Institute of Child Health, London, UK
    Eur J Cardiothorac Surg 31:654-8. 2007
    Pulmonary regurgitation after tetralogy of Fallot (ToF) repair is associated with right ventricular dilatation, failure and arrhythmia. Timing and technique for re-intervention remain controversial.
  64. ncbi Exercise performance in tetralogy of Fallot: the impact of primary complete repair in infancy
    W T Mahle
    The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Cardiol 23:224-9. 2002
    Primary complete repair (PCR) of tetralogy of Fallot (TOF) is now routinely performed in infancy. Although operative results are excellent, the impact on exercise performance is incompletely understood...
  65. ncbi Prevalence of left ventricular systolic dysfunction in adults with repaired tetralogy of fallot
    Craig S Broberg
    Oregon Health and Science University, Portland, Oregon
    Am J Cardiol 107:1215-20. 2011
    Left ventricular (LV) systolic dysfunction has been observed in patients with repaired tetralogy of Fallot (TOF), although its clinical associations are unknown...
  66. ncbi Adrenergic nervous activity in patients after surgical correction of tetralogy of Fallot
    L Daliento
    Department of Cardiology, University of Padua Medical School, Padua, Italy
    J Am Coll Cardiol 38:2043-7. 2001
    The study was done to define the role of the autonomic nervous system in postoperative tetralogy of Fallot.
  67. ncbi Delineation of a less than 200 kb minimal deleted region for cardiac malformations on chromosome 7p22
    Elliott G Richards
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 155:1729-34. 2011
    ..In this report, we describe a 16-month-old male with tetralogy of Fallot, bilateral second branchial arch remnants, and mild dysmorphic features...
  68. ncbi Postconditioning in cardiac surgery for tetralogy of Fallot
    Wanjun Luo
    Department of Cardiothoracic Surgery, Xiang Ya Hospital, Central South University, Changsha, Hunan, PR China
    J Thorac Cardiovasc Surg 133:1373-4. 2007
  69. ncbi Tricuspid regurgitation in patients with repaired Tetralogy of Fallot and its relation to right ventricular dilatation
    William T Mahle
    Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Am J Cardiol 92:643-5. 2003
    In a cohort of 56 school-aged children with repaired tetralogy of Fallot, significant (moderate to severe) tricuspid regurgitation was common (32% of patients) and was related to both tricuspid annulus dilatation and structural valve ..
  70. ncbi Current strategies in tetralogy of Fallot repair: pulmonary valve sparing and evolution of right ventricle/left ventricle pressures ratio
    Lorenzo Boni
    Pediatric Cardiac Institute of Doce de Otubre University Hospital, Madrid, Spain
    Eur J Cardiothorac Surg 35:885-9; discussion 889-90. 2009
    Chronic volume overload in repair of tetralogy of Fallot (TOF) with transannular patch leads to significant late morbidity and mortality...
  71. ncbi Pulmonary regurgitation is a powerful factor influencing QRS duration in patients after surgical repair of tetralogy of Fallot. A magnetic resonance imaging (MRI) study
    M Grothoff
    Department of Radiology and Nuclear Medicine, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Clin Res Cardiol 95:643-9. 2006
    ..prolongation is a negative prognostic factor for the development of ventricular arrhythmia after repair of tetralogy of Fallot (TOF)...
  72. ncbi Pregnancy in women with corrected tetralogy of Fallot: occurrence and predictors of adverse events
    Ali Balci
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am Heart J 161:307-13. 2011
    In women with corrected tetralogy of Fallot (ToF), pregnancy is associated with maternal cardiac, obstetric, and offspring complications...
  73. ncbi Right and left ventricular systolic function late after repair of tetralogy of Fallot
    M A Gatzoulis
    Department of Medicine, University of Toronto Congenital Cardiac Centre for Adults, University Health Network, University of Toronto, Ontario, Canada
    Am J Cardiol 86:1352-7. 2000
    Right ventricular (RV) dysfunction has adverse effects on long-term outcome in patients with repaired tetralogy of Fallot (TOF)...
  74. ncbi Aortic stiffness and aortic dilation in infants and children with tetralogy of Fallot before corrective surgery: evidence for intrinsically abnormal aortic mechanical property
    Mitsuru Seki
    Department of Pediatric Cardiology, International Medical Center, Saitama Medical University, Saitama, Japan
    Eur J Cardiothorac Surg 41:277-82. 2012
    ..tested the hypothesis that there is an intrinsic abnormality of aortic elasticity in infants/children with tetralogy of Fallot (TOF) before corrective surgery...
  75. pmc Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: an additional mechanism of diastolic dysfunction and interventricular dyssynchrony
    Ai Min Sun
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, M5G1X8, Canada
    J Cardiovasc Magn Reson 13:43. 2011
    Diastolic dysfunction of the right ventricle (RV) is common after repair of tetralogy of Fallot. While restrictive physiology in late diastole has been well known, dysfunction in early diastole has not been described...
  76. ncbi Right ventricular-left ventricular interaction in adults with Tetralogy of Fallot: a combined cardiac magnetic resonance and echocardiographic speckle tracking study
    Aleksander Kempny
    Adult Congenital and Valvular Heart Disease Center, Department of Cardiology and Angiology, University Hospital of Muenster, Muenster, Germany
    Int J Cardiol 154:259-64. 2012
    To assess ventricular dysfunction and ventricular interaction after repair of Tetralogy of Fallot (ToF) employing echocardiography speckle-tracking and cardiac magnetic resonance imaging (CMR).
  77. ncbi Aortic elasticity and size are associated with aortic regurgitation and left ventricular dysfunction in tetralogy of Fallot after pulmonary valve replacement
    H B Grotenhuis
    Department of Radiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Heart 95:1931-6. 2009
    Aortic wall pathology and concomitant aortic dilatation have been described in tetralogy of Fallot (TOF) patients, which may negatively affect aortic valve and left ventricular systolic function.
  78. ncbi Impact of pressure load caused by right ventricular outflow tract obstruction on right ventricular volume overload in patients with repaired tetralogy of Fallot
    Byung Won Yoo
    Division of Pediatric Cardiology, Yonsei University College of Medicine, Seoul, Korea
    J Thorac Cardiovasc Surg 143:1299-304. 2012
    In correction of tetralogy of Fallot (TOF), surgical strategies to minimize right ventricular outflow tract (RVOT) enlargement have recently been preferred...
  79. ncbi Impact of right ventricular dilation on left ventricular myocardial deformation in patients after surgical repair of tetralogy of fallot
    Eddie W Y Cheung
    Department of Paediatrics, Queen Mary Hospital, University of Hong Kong, China
    Am J Cardiol 104:1264-70. 2009
    ..is 1 of the major determinants of late adverse clinical outcomes in patients after surgical repair of tetralogy of Fallot (TOF)...
  80. ncbi Magnetic resonance imaging to assess the hemodynamic effects of pulmonary valve replacement in adults late after repair of tetralogy of fallot
    Hubert W Vliegen
    Department of Cardiology, Leiden University Medical Center, The Netherlands H W Vliegen LUMC nl
    Circulation 106:1703-7. 2002
    Pulmonary regurgitation (PR) late after total correction for tetralogy of Fallot may lead to progressive right ventricular (RV) dilatation and an increased incidence of severe arrhythmias and sudden death...
  81. ncbi Relation of left ventricular dyssynchrony measured by cardiac magnetic resonance tissue tracking in repaired tetralogy of fallot to ventricular tachycardia and death
    Marta Ortega
    Department of Cardiology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 107:1535-40. 2011
    The impact of left ventricular (LV) dyssynchrony on clinical outcomes in patients with tetralogy of Fallot (TOF) is unknown...
  82. ncbi Remodelling of the right ventricle after early pulmonary valve replacement in children with repaired tetralogy of Fallot: assessment by cardiovascular magnetic resonance
    Emanuela R Valsangiacomo Buechel
    Division of Pediatric Cardiology, University Children s Hospital, Zurich, Switzerland
    Eur Heart J 26:2721-7. 2005
    ..preventing complications of pulmonary regurgitation and right ventricular (RV) dilatation after repair of tetralogy of Fallot. We sought to assess the remodelling of the RV after early PVR in children, using cardiovascular magnetic ..
  83. ncbi A contemporary assessment of the risk for sudden cardiac death in patients with congenital heart disease
    Michael J Silka
    Division of Cardiology, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    Pediatr Cardiol 33:452-60. 2012
    ..Sudden cardiac death in CHD patients has been studied most extensively in tetralogy of Fallot. More than 30 risk factors have been proposed, with age at repair, QRS duration, right ventricular ..
  84. ncbi Reduction of QRS duration after pulmonary valve replacement in adult Fallot patients is related to reduction of right ventricular volume
    Bart Hooft Van Huysduynen
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Heart J 26:928-32. 2005
    ..Pulmonary regurgitation is a common cause of right ventricular (RV) failure and QRS lengthening. We studied the effects of pulmonary valve replacement (PVR) on QRS duration and RV volume...
  85. ncbi Relation of fragmented QRS complex to right ventricular fibrosis detected by late gadolinium enhancement cardiac magnetic resonance in adults with repaired tetralogy of fallot
    Seung Jung Park
    Department of Internal Medicine, Cardiovascular Imaging Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Am J Cardiol 109:110-5. 2012
    ..magnetic resonance (CMR) is reportedly correlated with worse clinical outcomes in adults with repaired tetralogy of Fallot (TOF)...
  86. ncbi Long-term follow-up of homograft function after pulmonary valve replacement in patients with tetralogy of Fallot
    Thomas Oosterhof
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur Heart J 27:1478-84. 2006
    To analyse the long-term outcomes after pulmonary valve replacement (PVR) in patients with a previous correction for tetralogy of Fallot.
  87. ncbi Late pulmonary valve replacement after repair of tetralogy of Fallot
    B Discigil
    Division of Cardiovascular and Thoracic Surgery, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Thorac Cardiovasc Surg 121:344-51. 2001
    BACKGROUND: Pulmonary regurgitation appears to be well tolerated early after repair of tetralogy of Fallot; however, it may result in progressive right ventricular dilatation and dysfunction necessitating eventual valve replacement...
  88. ncbi Early insertion of a pulmonary valve for chronic regurgitation helps restoration of ventricular dimensions
    Hitendu Hasmukhlal Dave
    Division of Congenital Cardiac Surgery, University Children s Hospital Zurich, Zurich, Switzerland
    Ann Thorac Surg 80:1615-20; discussion 1620-1. 2005
    ..This study assesses the results of early insertion of a pulmonary valve for chronic pulmonary regurgitation based on right ventricular volume measurements...
  89. ncbi Correlation of right ventricular ejection fraction and tricuspid annular plane systolic excursion in tetralogy of Fallot by magnetic resonance imaging
    Peter Morcos
    The Cardiovascular Research and Training Center, University of Washington, Seattle, WA 98195 6422, USA
    Int J Cardiovasc Imaging 25:263-70. 2009
    ..We tested whether TAPSE measurements by MRI correlate with RVEF in surgically repaired tetralogy of Fallot (TOF) patients...
  90. ncbi Assessment of interventricular and right-intraventricular dyssynchrony in patients with surgically repaired tetralogy of Fallot by two-dimensional speckle tracking
    Matthias Mueller
    Department of Paediatric Cardiology, Saarland University Hospital, Kirrberger Strase, 66421 Homburg Saar, Germany
    Eur J Echocardiogr 11:786-92. 2010
    We aimed to assess interventricular and right-intraventricular dyssynchrony in patients after tetralogy of Fallot (TOF) repair by two-dimensional (2D) speckle tracking and to identify factors associated with dyssynchrony.
  91. ncbi Right ventricle three-dimensional echography in corrected tetralogy of fallot: accuracy and variability
    Xavier Iriart
    Service des Cardiopathies Congénitales de l Enfant et de l Adulte, CHU de Bordeaux, Pessac, France
    Eur J Echocardiogr 10:784-92. 2009
    To evaluate right ventricular (RV) volume and ejection fraction (EF) in adult normal subjects and repaired tetralogy of Fallot (ToF) with 3D trans-thoracic echocardiography (3DE) and a semi-automatic border detection algorithm.
  92. pmc Effects of regional dysfunction and late gadolinium enhancement on global right ventricular function and exercise capacity in patients with repaired tetralogy of Fallot
    Rachel M Wald
    Department of Cardiology, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Circulation 119:1370-7. 2009
    ..mechanisms that contribute to global right ventricular (RV) dysfunction in patients with repaired tetralogy of Fallot are incompletely understood...
  93. ncbi Outcomes of pregnancy in women with tetralogy of Fallot
    Gruschen R Veldtman
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 44:174-80. 2004
    We sought to determine pregnancy outcomes in patients with tetralogy of Fallot (TOF).
  94. ncbi Right ventricular mechanics and QRS duration in patients with repaired tetralogy of Fallot: implications of infundibular disease
    Anselm Uebing
    Adult Congenital Heart Disease Centre, Royal Brompton Hospital, Sydney St, London SW3 6NP, UK
    Circulation 116:1532-9. 2007
    Patients after repair of tetralogy of Fallot (ToF) frequently have right ventricular (RV) dysfunction and prolonged QRS duration (QRSd) and thus could be candidates for cardiac resynchronization therapy...
  95. ncbi Right ventricular myocardial dysfunction in adult patients late after repair of tetralogy of fallot
    A D'ANDREA
    Monaldi Hospital, Second University of Naples, Italy
    Int J Cardiol 94:213-20. 2004
    To detect in adult patients late after repair of Tetralogy of Fallot (TOF) possible correlation between myocardial parameters assessed at rest by Tissue Doppler (TD) and cardiac performance during physical effort.
  96. ncbi Meta-analysis of pulmonary valve replacement after operative repair of tetralogy of fallot
    Eddie Wai yin Cheung
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, People s Republic of China
    Am J Cardiol 106:552-7. 2010
    ..right ventricular (RV) function of surgical pulmonary valve replacement (PVR) in patients after repair of tetralogy of Fallot. The reported outcomes of surgical PVR in children and adults after tetralogy of Fallot repair were from ..
  97. ncbi The influence of pulmonary regurgitation on regional right ventricular function in children after surgical repair of tetralogy of Fallot
    Benedicte Eyskens
    Department of Paediatric Cardiology, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Echocardiogr 11:341-5. 2010
    Pulmonary regurgitation after repair of tetralogy of Fallot (TOF) results in right ventricular (RV) dysfunction with significant late morbidity and mortality...
  98. ncbi Influence of pulmonary regurgitation inequality on differential perfusion of the lungs in tetralogy of Fallot after repair: a phase-contrast magnetic resonance imaging and perfusion scintigraphy study
    Ming Ting Wu
    Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    J Am Coll Cardiol 49:1880-6. 2007
    The purpose of this study was to evaluate the influence of pulmonary regurgitation inequality on differential perfusion of the lungs in tetralogy of Fallot (TOF) after repair.
  99. ncbi Diastolic function in repaired tetralogy of Fallot at rest and during stress: assessment with MR imaging
    Jochem van den Berg
    Department of Pediatric Cardiology, Sophia Children s Hospital, Erasmus Medical Center, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Radiology 243:212-9. 2007
    ..assess, with magnetic resonance (MR) imaging, right ventricular (RV) diastolic function after repair of tetralogy of Fallot (TOF) at rest and during pharmacologic stress and to study relationship between main pulmonary artery end-..
  100. ncbi Value of the new Doppler-derived myocardial performance index for the evaluation of right and left ventricular function following repair of tetralogy of fallot
    M Y Abd El Rahman
    Department of Congenital Heart Disease, Deutsches Herzzentrum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Pediatr Cardiol 23:502-7. 2002
    ..and diastolic function in both ventricles may be altered even after successful corrective surgery of tetralogy of Fallot. The aim of this study was to assess the combined diastolic and systolic function of both ventricles using ..
  101. ncbi Regional wall motion and abnormalities of electrical depolarization and repolarization in patients after surgical repair of tetralogy of Fallot
    M Vogel
    Grown Up Congenital Heart GUCH Unit, Middlesex Hospital, London, UK
    Circulation 103:1669-73. 2001
    Abnormal depolarization-repolarization in patients with repaired tetralogy of Fallot (TOF) is a risk factor for malignant ventricular tachycardia and sudden death...

Research Grants30

  1. Resuscitation using novel impedance threshold devices in pediatrics
    Keith G Lurie; Fiscal Year: 2013
    ..sepsis or b) who have undergone cardiac surgery for congenital heart disease (CHD) (single ventricle or tetralogy of Fallot)...
  2. Role of endocytosis by the neural crest in cardio-craniofacial development
    ANNA LUISE KEYTE; Fiscal Year: 2013
    ..syndromes are highly variable, but are frequently characterized by congenital heart disease, especially tetralogy of Fallot, and cleft palate...
  3. The role of Lmp4 in the regulation of the cardiac transcription factor Tbx5
    Hans Georg Simon; Fiscal Year: 2010
    ..this heart/limb disease range from atrial and ventricular septal defects to complex malformations such as tetralogy of Fallot. The HOS phenotypes can result form either reduced or increased amounts of Tbx5, indicating that the levels ..
  4. Characterization of Cardiac Progenitors Derived from 22q11-deleted Patients
    WILLIAM TSWENCHING contact PU; Fiscal Year: 2010
    ..test this hypothesis using induced-pluripotent (iPS) cells derived from 22q11-deleted patients with tetralogy of Fallot (TOF). First, we will generate a repository of TOF fibroblasts and parental controls...
  5. Mechanisms of Nural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2010
    ..Mutations in Pbx genes lead to persistent truncus arteriosus, tetralogy of Fallot, overriding aorta and bicuspid aortic valves...
  6. Excitation-contraction coupling in human ventricle development
    Mary B Wagner; Fiscal Year: 2012
    ..left heart syndrome to ventricular biopsies removed at 3-12 months (infants) of age from children with Tetralogy of Fallot. A better understanding of contraction regulation in infants may suggest therapies that are more ..
  7. Chromosomal microdeletions causing heart defects
    EDWARD JAMES LAMMER; Fiscal Year: 2013
    ..We found that nearly 2% of boys with tetralogy of Fallot have an extra sex chromosome material...
  8. Transcriptional Control of Right Ventricular and Outflow Tract Development
    Ian S Harris; Fiscal Year: 2012
    ..The Tetralogy of Fallot is the most common cyanotic congenital heart disease and outflow tract defects as a group comprise the ..
  9. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..Associated abnormalities include tetralogy of Fallot, cleft palate, hydrops fetalis and cystic hygroma...
  10. Exploring the role of dyssynchrony in pediatric heart disease with MRI
    Brandon K Fornwalt; Fiscal Year: 2013
    ..this challenge in a population of patients with a common, serious congenital heart defect known as tetralogy of Fallot (TOF)...
  11. The Role of Notch Signaling in Arrhythmogenesis
    STACEY LYNN RENTSCHLER; Fiscal Year: 2013
    ..of many malignancies, as well as cardiac developmental defects such as bicuspid aortic valve and tetralogy of Fallot. However, a role for Notch in arrhythmic phenotypes has not previously been described...
  12. The Genetic Basis of Conotruncal Defects
    Elizabeth Goldmuntz; Fiscal Year: 2013
    ..Finally, analyses exploring the association of genotype with clinical outcome in the subset of cases with tetralogy of Fallot will be performed...
  13. Advanced Source Reconstruction Techniques for Fetal Magnetocardiography
    Mihai Popescu; Fiscal Year: 2009
    ..growth retardation, diabetes, pulmonary valve and aortic stenosis, closure of the ductus arteriosus, tetralogy of Fallot, or ventricular septal defect...
  14. ETIOLOGY AND DEVELOPMENT OF CONGENITAL HEART DISEASES
    Donald Patterson; Fiscal Year: 1999
    ..Abnormal development of the conotruncal septum, producing ventricular septal defect, tetralogy of Fallot, or persistent truncus arteriosus, is associated with a generalized failure of growth of right ventricular ..
  15. REPRODUCTION AND SURVIVAL AFTER CARDIAC DEFECT REPAIR
    Cynthia Morris; Fiscal Year: 1991
    ..prevalent defects: ventricular septal defect (VSD), atrial septal defect (ASD), pulmonic stenosis (PS), tetralogy of Fallot (TOF), coarctation of the aorta, aortic stenosis (AS), transposition of the great arteries (TGA), and ..
  16. MODEL OF DYSRHYTHMIAS AFTER CONGENITAL HEART SURGERY
    Arthur Garson; Fiscal Year: 1991
    ..research designed to model the problem of sudden death after repair of congenital heart defects such as tetralogy of Fallot (TOF)...
  17. POSTOPERATIVE ARRHYTHMIAS: IDENTIFICATION AND MECHANISMS
    Victoria Vetter; Fiscal Year: 1990
    ..The incidence of sudden death in patients who have had repairs of tetralogy of Fallot and transposition of the great arteries as well as other complex lesions exceeds 5%...
  18. Molecular Biology of Cardiac Valvuloseptal Morphogenesis
    DAVID GEENAN; Fiscal Year: 2006
    ..ligand for the Notch signaling pathway that is deleted or mutated in Alagille syndrome and in some cases of tetralogy of Fallot. We have induced a targeted mutation in the mouse Hey1 and Hey2 genes, basic Helix-Loop-Helix (bHLH) ..
  19. Highly Automated Analysis of 4-D Cardiovascular MR Data
    Milan Sonka; Fiscal Year: 2006
    ..cardiac image segmentation method, this proposal focuses on two groups of subjects - postoperative tetralogy of Fallot patients and patients with connective tissue disorders...
  20. The Genetic Etiology of Left-Sided Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..In addition, these investigations will lead to future studies that assess the relationship of genotype to clinical outcome, and allow us to improve upon our clinical management accordingly. [unreadable] [unreadable]..
  21. Expert Visual Guidance of Ultrasound for Telemedicine
    Florence Sheehan; Fiscal Year: 2006
    ..Specific Aim #4 is to make the guidance easily applicable to different organs. [unreadable] [unreadable]..
  22. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. [unreadable] [unreadable]..
  24. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  25. Conotruncal defects: genetic and nutritional risk
    EDWARD JAMES LAMMER; Fiscal Year: 2010
    ....
  26. Pediatric Thin-Film TiNi Catheter-Based Heart Valve
    Daniel Levi; Fiscal Year: 2005
    ..Phase II studies will focus on accelerated wear testing, long-term in vivo animal testing, and manufacturing issues. ..
  27. Multidisciplinary Study of Right Ventricular Dysplasia
    Jeffrey Towbin; Fiscal Year: 2005
    ..This integrated research grant proposal offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and of localizing the gene(s) responsible for this disorder. ..
  28. VENTRICULAR FUNCTION DURING CARDIAC SURGERY
    HENRY SPOTNITZ; Fiscal Year: 2005
    ....
  29. Molecular Analysis of Alagille Syndrome
    NANCY SPINNER; Fiscal Year: 2006
    ..abstract_text> ..