atrial heart septal defects

Summary

Summary: Defects in the septum between the atria of the heart, due to failure of fusion between either the septum secundum or the septum primum and the endocardial cushions.

Top Publications

  1. ncbi Atrial septal defect in adults
    Martin Rosas
    Adult Cardiology Department, National Institute of Cardiology of Mexico, Mexico City, Mexico
    Timely Top Med Cardiovasc Dis 11:E34. 2007
  2. ncbi Congenital heart disease caused by mutations in the transcription factor NKX2-5
    J J Schott
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 281:108-11. 1998
  3. ncbi Early and late complications associated with transcatheter occlusion of secundum atrial septal defect
    Massimo Chessa
    Pediatric Cardiology, Istituto Policlinico San Donato, San Donato Milanese, Italy
    J Am Coll Cardiol 39:1061-5. 2002
  4. ncbi NKX2.5 mutations in patients with congenital heart disease
    Doff B McElhinney
    The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 42:1650-5. 2003
  5. ncbi Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome
    David A Elliott
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
    J Am Coll Cardiol 41:2072-6. 2003
  6. ncbi Improvement in exercise capacity in asymptomatic and mildly symptomatic adults after atrial septal defect percutaneous closure
    Marie Claude Brochu
    Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 106:1821-6. 2002
  7. pmc Left ventricular adaptation after atrial septal defect closure assessed by increased concentrations of N-terminal pro-brain natriuretic peptide and cardiac magnetic resonance imaging in adult patients
    M Weber
    Department of Cardiology, Kerckhoff Heart Centre, Bad Nauheim, Germany
    Heart 92:671-5. 2006
  8. ncbi Migraine headache relief after transcatheter closure of patent foramen ovale
    Mark Reisman
    Cardiovascular Research, Swedish Medical Center
    J Am Coll Cardiol 45:493-5. 2005
  9. ncbi Shunt-associated migraine responds favorably to atrial septal repair: a case-control study
    Gian P Anzola
    Servizio di Neurologia, Ospedale S Orsola FBF, AFaR, Associazione Fatebenefratelli per la Ricerca, Brescia, Italy
    Stroke 37:430-4. 2006
  10. ncbi Comparison of results and complications of surgical and Amplatzer device closure of atrial septal defects
    F Berger
    Klinik für Angeborene Herzfehler und Klinik für Herz, Thorax und Gefasschirurgie, Deutsches Herzzentrum, Berlin, Germany
    J Thorac Cardiovasc Surg 118:674-8; discussion 678-80. 1999

Research Grants

Detail Information

Publications210 found, 100 shown here

  1. ncbi Atrial septal defect in adults
    Martin Rosas
    Adult Cardiology Department, National Institute of Cardiology of Mexico, Mexico City, Mexico
    Timely Top Med Cardiovasc Dis 11:E34. 2007
    ..The safety and efficacy of a transcatheter occluder system was superior to surgery with regard to some complications, although this difference was not significant in young adults (<40 years)...
  2. ncbi Congenital heart disease caused by mutations in the transcription factor NKX2-5
    J J Schott
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 281:108-11. 1998
    ..These data indicate that NKX2-5 is important for regulation of septation during cardiac morphogenesis and for maturation and maintenance of atrioventricular node function throughout life...
  3. ncbi Early and late complications associated with transcatheter occlusion of secundum atrial septal defect
    Massimo Chessa
    Pediatric Cardiology, Istituto Policlinico San Donato, San Donato Milanese, Italy
    J Am Coll Cardiol 39:1061-5. 2002
    ..The goal of this study was to report the early and late complications experienced in atrial septal defect (ASD) transcatheter closure...
  4. ncbi NKX2.5 mutations in patients with congenital heart disease
    Doff B McElhinney
    The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 42:1650-5. 2003
    ..The purpose of this study was to estimate the frequency of NKX2.5 mutations in specific cardiovascular anomalies and investigate genotype-phenotype correlations in individuals with NKX2.5 mutations...
  5. ncbi Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome
    David A Elliott
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
    J Am Coll Cardiol 41:2072-6. 2003
    ..We sought to examine the importance of mutations in the cardiac transcription factor gene NKX2-5 in patients with an atrial septal defect (ASD), patent foramen ovale (PFO), or hypoplastic left heart syndrome (HLHS)...
  6. ncbi Improvement in exercise capacity in asymptomatic and mildly symptomatic adults after atrial septal defect percutaneous closure
    Marie Claude Brochu
    Montreal Heart Institute, Montreal, Quebec, Canada
    Circulation 106:1821-6. 2002
    ..Controversy exists as to whether secundum atrial septal defects (ASDs) in asymptomatic or mildly symptomatic New York Heart Association (NYHA) class I or II adult patients should be closed...
  7. pmc Left ventricular adaptation after atrial septal defect closure assessed by increased concentrations of N-terminal pro-brain natriuretic peptide and cardiac magnetic resonance imaging in adult patients
    M Weber
    Department of Cardiology, Kerckhoff Heart Centre, Bad Nauheim, Germany
    Heart 92:671-5. 2006
    ..To determine in an observational study whether N-terminal pro-brain natriuretic peptide (NT-proBNP) is raised in patients with an atrial septal defect (ASD) and whether concentrations change after interventional closure...
  8. ncbi Migraine headache relief after transcatheter closure of patent foramen ovale
    Mark Reisman
    Cardiovascular Research, Swedish Medical Center
    J Am Coll Cardiol 45:493-5. 2005
    ..The purpose of this study was to determine the effects of transcatheter patent foramen ovale (PFO) closure on migraine frequency in patients with paradoxical cerebral embolism...
  9. ncbi Shunt-associated migraine responds favorably to atrial septal repair: a case-control study
    Gian P Anzola
    Servizio di Neurologia, Ospedale S Orsola FBF, AFaR, Associazione Fatebenefratelli per la Ricerca, Brescia, Italy
    Stroke 37:430-4. 2006
    ....
  10. ncbi Comparison of results and complications of surgical and Amplatzer device closure of atrial septal defects
    F Berger
    Klinik für Angeborene Herzfehler und Klinik für Herz, Thorax und Gefasschirurgie, Deutsches Herzzentrum, Berlin, Germany
    J Thorac Cardiovasc Surg 118:674-8; discussion 678-80. 1999
    ..Results and complications of surgical versus transcatheter treatment of atrial septal defect in the current era are compared...
  11. ncbi Intracardiac echocardiography is superior to conventional monitoring for guiding device closure of interatrial communications
    Thomas Bartel
    Division of Cardiology, Department of Internal Medicine, University of Essen, Essen, Germany
    Circulation 107:795-7. 2003
    ..This study sought to test whether intracardiac echocardiography (ICE) is superior to conventional monitoring in guiding device closure of interatrial communications (atrial septal defect [ASD] and patent foramen ovale [PFO])...
  12. ncbi Closure of secundum atrial septal defects with the Amplatzer septal occluder device: techniques and problems
    Richard W Harper
    Centre for Heart and Chest Research, Monash University and Monash Medical Centre Clayton, Victoria, Melbourne, Australia
    Catheter Cardiovasc Interv 57:508-24. 2002
    ....
  13. ncbi The influence of percutaneous atrial septal defect closure on the occurrence of migraine
    Katrin Mortelmans
    Department of Cardiology, Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Heart J 26:1533-7. 2005
    ..Percutaneous patent foramen ovale closure seems to influence migraine. We wanted to observe the effect of percutaneous atrial septal defect (ASD) closure on migraine...
  14. ncbi Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults: results of a multicenter nonrandomized trial
    Zhong Dong Du
    Section of Pediatric Cardiology, Department of Pediatrics, University of Chicago Children s Hospital, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Am Coll Cardiol 39:1836-44. 2002
    ..This study sought to compare the safety, efficacy and clinical utility of the Amplatzer septal occluder (ASO) for closure of secundum atrial septal defect (ASD) with surgical closure...
  15. ncbi Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse
    Edwin P Kirk
    Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, Australia
    Circ Res 98:651-8. 2006
    ..Thus, multiple anatomical processes under separate genetic control contribute to risk of PFO. Our findings demonstrate the feasibility of modeling the genetic basis of common CHD using animal genetic and genomic technologies...
  16. pmc Experience with transcatheter closure of secundum atrial septal defects using the Amplatzer septal occluder: a single centre study in 236 consecutive patients
    G Fischer
    Department of Paediatric Cardiology and Biomedical Engineering, Universitatsklinikum Kiel, Kiel, Germany
    Heart 89:199-204. 2003
    ..To evaluate the safety and efficacy of transcatheter closure of secundum atrial septal defects (ASD) with the Amplatzer septal occluder...
  17. ncbi Familial recurrence of congenital heart disease in patients with ostium secundum atrial septal defect
    Salvatore Caputo
    Pediatric Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy
    Eur Heart J 26:2179-84. 2005
    ....
  18. ncbi Morphological variations of secundum-type atrial septal defects: feasibility for percutaneous closure using Amplatzer septal occluders
    T Podnar
    The Children s Cardiac Center, University Children s Hospital, Bratislava, Slovakia
    Catheter Cardiovasc Interv 53:386-91. 2001
    ..Cathet Cardiovasc Intervent 2001;53:386-391...
  19. ncbi Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5
    C Biben
    Victor Chang Cardiac Research Institute, Darlinghurst, Australia
    Circ Res 87:888-95. 2000
    ..Our data demonstrate that the complex effects of Nkx2-5 haploinsufficiency in mice are weaker but convergent with those in humans. As in the mouse, the phenotype of human NKX2-5 mutations may be modulated by interacting alleles...
  20. ncbi Transvenous closure of secundum atrial septal defects: preliminary results with a new self-expanding nitinol prosthesis in a swine model
    M J Sharafuddin
    Department of Radiology, University of Minnesota Hospital and Clinic Minneapolis, 55455, USA
    Circulation 95:2162-8. 1997
    ..Our purpose was to evaluate a new prosthesis for percutaneous closure of secundum atrial septal defects (ASDs)...
  21. ncbi Prevalence and size of directly detected patent foramen ovale in migraine with aura
    M Schwerzmann
    Department of Cardiology, University Hospital, Inselspital, CH 3010 Bern, Switzerland
    Neurology 65:1415-8. 2005
    ..The anatomy and size of these right-to-left shunts have never been directly assessed...
  22. ncbi Evidence of adverse ventricular interdependence in patients with atrial septal defects
    Roxanne E Walker
    Department of Cardiology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Am J Cardiol 93:1374-7, A6. 2004
    ..Thus, LV dysfunction associated with RV volume overload is secondary to altered chamber geometry and decreased myofiber preload. This physiology is immediately reversible and is independent of heart rate and afterload...
  23. ncbi Is patent foramen ovale a family trait? A transcranial Doppler sonographic study
    C Arquizan
    Service de Neurologie, Hopital Sainte Anne, Paris, France
    Stroke 32:1563-6. 2001
    ..Patent foramen ovale (PFO) is a frequent finding in young patients with stroke. The aim of this study was to assess whether PFO is a family trait...
  24. ncbi Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both
    J L Mas
    Department of Neurology, Sainte Anne Hospital, Paris V University, Paris, France
    N Engl J Med 345:1740-6. 2001
    ..We studied the risks of recurrent cerebrovascular events associated with these cardiac abnormalities...
  25. ncbi Closure of atrial septal defect in the adult. Cardiac remodeling is an early event
    U Thilen
    Department of Cardiology, Lund University, Lund University Hospital, SE 221 85 Lund, Sweden
    Int J Cardiol 108:370-5. 2006
    ..Study aimed to describe the extent and the temporal profile of cardiac remodeling after atrial septal defect closure in the adult...
  26. ncbi Choice of device size and results of transcatheter closure of atrial septal defect using the amplatzer septal occluder
    Zhong Dong Du
    Section of Pediatric Cardiology, Department of Pediatrics, University of Chicago Children s Hospital, Pritzker School of Medicine, Chicago, Illinois, USA
    J Interv Cardiol 15:287-92. 2002
    ..The complication rates were similar in all groups. In conclusion, a choice of a device size identical to or within 2 mm larger than the SD of the defect should be used to maximize the closure rates of ASD using the ASO...
  27. ncbi Transcatheter closure of interatrial communications for secondary prevention of paradoxical embolism: single-center experience
    Leonhard Bruch
    Unfallkrankenhaus Berlin, Department of Internal Medicine Cardiology, Berlin, Germany
    Circulation 105:2845-8. 2002
    ..After 3 months, only 2 patients showed a residual shunt, which disappeared in both cases after 12 months. In 112.2 patient-years of follow-up (range, 5 weeks to 3.5 years), we have not seen any recurrent thromboembolic event...
  28. ncbi Transcatheter closure as standard treatment for most interatrial defects: experience in 200 patients treated with the Amplatzer Septal Occluder
    F Berger
    Klinik für Angeborene Herzfehler, Deutsches Herzzentrum Berlin, Germany
    Cardiol Young 9:468-73. 1999
    ..Final judgement, however, is only possible after long-term follow-up...
  29. ncbi Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies
    J R Overell
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Neurology 55:1172-9. 2000
    ..To examine the association between patent foramen ovale (PFO) and atrial septal aneurysm (ASA) and stroke...
  30. ncbi Absent posteroinferior and anterosuperior atrial septal defect rims: Factors affecting nonsurgical closure of large secundum defects using the Amplatzer occluder
    James W Mathewson
    Divisions of Cardiology, Children s Hospital San Diego, in affiliation with the University of California at San Diego, San Diego, California, USA
    J Am Soc Echocardiogr 17:62-9. 2004
    ....
  31. pmc A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family
    A Okubo
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 41:e97. 2004
  32. ncbi Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect
    Kayoko Hirayama-Yamada
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Am J Med Genet A 135:47-52. 2005
    ..5 for which classification has not been clearly proposed. This pinpoints essential sites of NKX2.5 in the development of the conduction system...
  33. ncbi Self-fabricated fenestrated Amplatzer occluders for transcatheter closure of atrial septal defect in patients with left ventricular restriction: midterm results
    B Peters
    Dept of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Clin Res Cardiol 95:88-92. 2006
    ..We describe technical preparation of the standard occluder, the specific implantation technique, and the initial and the intermediate term results up to 24 months...
  34. ncbi Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks
    M Schwerzmann
    Department of Cardiology, University Hospital, Bern, Switzerland
    Neurology 62:1399-401. 2004
    ..2 +/- 0.7 vs 0.4 +/- 0.4 per month; p = 0.006). PFO closure did not have an effect on headache frequency in patients with nonmigraine headaches (1.4 +/- 0.9 vs 1.0 +/- 0.9 per month; p = NS)...
  35. ncbi Bland-White-Garland syndrome and atrial septal defect - rare association and diagnostic challenge
    T Schneider
    Kantonsspital St Gallen, Department Innere Medizin, Fachbereich Kardiologie, Rorschacherstr 95, 9007, St Gallen, Switzerland
    Clin Res Cardiol 95:295-300. 2006
    ....
  36. ncbi Assessment of atrial septal defect area changes during cardiac cycle by live three-dimensional echocardiography
    Ming Xing Xie
    Department of Echocardiography, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Cardiol 47:181-7. 2006
    ..To investigate the accuracy of measurement of the atrial septal defect (ASD)area and dynamic change by live three-dimensional echocardiography (L3DE)...
  37. ncbi Predictors of successful transcatheter closure of atrial septal defect by cardiac magnetic resonance imaging
    K Durongpisitkul
    Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Prannok Road, Bangkok, Thailand 10700
    Pediatr Cardiol 25:124-30. 2004
    ..We believe that the most important predictive factor for successful transcatheter closure of an ASD is an adequate posterior inferior rim, which is best visualized using cardiac MRI...
  38. ncbi Use of non-invasive phase contrast magnetic resonance imaging for estimation of atrial septal defect size and morphology: a comparison with transesophageal echo
    Chin Sze Piaw
    Department of Cardiology, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, 93580, Sarawak, East Malaysia
    Cardiovasc Intervent Radiol 29:230-4. 2006
    ..Magnetic resonance imaging (MRI) may be useful non-invasive alternative in such patients who refuse or are unable to tolerate TEE and may provide additional information on the shape of the A0SD...
  39. ncbi Frequency of atrial tachyarrhythmias following transcatheter closure of patent foramen ovale
    Jamshid Alaeddini
    Heart Institute of Spokane, Spokane, Washington, USA
    J Invasive Cardiol 18:365-8. 2006
    ..However, the long-term effects of these closure devices on atrial tachyarrhythmias (ATs) are not known...
  40. ncbi Transcatheter closure of patent foramen ovale (PFO) in patients with paradoxical embolism. Periprocedural safety and mid-term follow-up results of three different device occluder systems
    M Braun
    Internal Medicine II, Department of Cardiology, Technical University of Dresden, Fetscherstr 76, 01307 Dresden, Germany
    Eur Heart J 25:424-30. 2004
    ..The aim of the present study was to evaluate three different occluder systems in respect to (a) the safety and practicability and (b) the mid-term risk of recurrent thromboembolic events...
  41. pmc Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura
    P T Wilmshurst
    The Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK
    Heart 90:1315-20. 2004
    ..To determine whether smaller atrial shunts (large persistent foramen ovale (PFO) and small atrial septal defect (ASD)) are inherited and whether this has a role in the inheritance of migraine with aura...
  42. pmc How should we assess patent foramen ovale?
    C Seiler
    Heart 90:1245-7. 2004
  43. pmc Symptomatic atrial arrhythmias and transcatheter closure of atrial septal defects in adult patients
    C K Silversides
    Toronto Congenital Cardiac Centre for Adults, University Health Network, Toronto, Canada
    Heart 90:1194-8. 2004
    ..To determine whether transcatheter device closure of a secundum atrial septal defect (ASD) will reduce the risk of developing subsequent atrial arrhythmias...
  44. ncbi TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts
    Stella Marie Reamon-Buettner
    Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, D 30625 Hannover, Germany
    Hum Mutat 24:104. 2004
    ..We show for the first time TBX5 mutations in non-HOS associated cardiac malformations and we identified a novel missense mutation that would impact nuclear localization of TBX5...
  45. ncbi A novel stop mutation truncating critical regions of the cardiac transcription factor NKX2-5 in a large family with autosomal-dominant inherited congenital heart disease
    S Pabst
    Medizinische Klinik II, Universitatsklinikum Bonn, S Freud Str 25, 53105, Bonn, Germany
    Clin Res Cardiol 97:39-42. 2008
    ..Therefore, it is very likely that this novel mutation causes a complete loss of NKX2-5 function and haploinsufficiency is the pathophysiological mechanism underlying the disease in the family...
  46. ncbi Effect of chronic right atrial stretch on atrial electrical remodeling in patients with an atrial septal defect
    Joseph B Morton
    Department of Cardiology, The Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, Australia
    Circulation 107:1775-82. 2003
    ..Adults with an atrial septal defect (ASD) frequently develop late atrial arrhythmias. We sought to characterize the pattern and persistence of atrial electrical remodeling caused by chronic right atrial (RA) stretch in this group...
  47. pmc Transcatheter closure of atrial septal defect and interatrial communications with a new self expanding nitinol double disc device (Amplatzer septal occluder): multicentre UK experience
    K C Chan
    Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Heart 82:300-6. 1999
    ..To review the safety and efficacy of the Amplatzer septal occluder for transcatheter closure of interatrial communications (atrial septal defects (ASD), fenestrated Fontan (FF), patent foramen ovale (PFO))...
  48. pmc Transcatheter closure of atrial septal defect preserves right ventricular function
    R Dhillon
    Department of Paediatric Cardiology, Royal Brompton Hospital, London SW3, UK
    Heart 87:461-5. 2002
    ....
  49. ncbi Prevalence of patent foramen ovale in migraine patients with and without aura compared with stroke patients. A transcranial Doppler study
    F J Carod-Artal
    Department of Neurology, The Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brazilia DF, Brazil
    Cephalalgia 26:934-9. 2006
    ..1% and 25% (P = 0.04). The difference between MA and MoA patients was significant (odds ratio = 2.1). The prevalence of PFO in MA patients is higher than in MoA patients and in young cryptogenic stroke patients...
  50. ncbi Echocardiologists' role in the deployment of the Amplatzer atrial septal occluder device in adults
    J C Cooke
    Centre for Heart and Chest Research, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Echocardiogr 14:588-94. 2001
    ..Figures, diagrams, and tables detail each stage of the evaluation, procedure, and postprocedural assessment...
  51. ncbi Surgical patent foramen ovale closure for prevention of paradoxical embolism-related cerebrovascular ischemic events
    J A Dearani
    Division of Thoracic and Cardiovascular Surgery, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Circulation 100:II171-5. 1999
    ..Our objective was to determine the outcome of surgical closure of PFO in patients with a prior ischemic neurological event, define the rate of CI or TIA recurrence after PFO closure, and identify risk factors for these recurrences...
  52. ncbi Incidence of atrial fibrillation following transcatheter closure of atrial septal defects in adults
    Christian Spies
    Section of Cardiology, Rush University Medical Center, Chicago, Illinois, USA
    Am J Cardiol 102:902-6. 2008
    ....
  53. ncbi Transcatheter closure of secundum atrial septal defect using an Amplatzer septal occluder
    Xiangqing Kong
    Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Chin Med J (Engl) 115:126-8. 2002
    ..To evaluate the safety and efficacy of the Amplatzer septal occluder for transcatheter closure in patients with secundum atrial septal defect (ASD II)...
  54. pmc Clopidogrel reduces migraine with aura after transcatheter closure of persistent foramen ovale and atrial septal defects
    P T Wilmshurst
    Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK
    Heart 91:1173-5. 2005
    ..To report the clinical events leading to alteration of an anticoagulation regimen for patients undergoing transcatheter closure of an atrial shunt and how this affected migraine symptoms after the closure procedure...
  55. ncbi Right ventricular form and function after percutaneous atrial septal defect device closure
    G R Veldtman
    Congenital Cardiac Centre for Adults, University of Toronto and Toronto General Hospital, Ontario, Canada
    J Am Coll Cardiol 37:2108-13. 2001
    ..A small number of patients had persistent RV enlargement or pulmonary hypertension, or both, at one year. Our data support the application of transcatheter methods in achieving excellent hemodynamic and anatomic outcomes...
  56. ncbi Contemporary management of patent foramen ovale
    Bernhard Meier
    Swiss Cardiovascular Center Bern, University of Bern, University Hospital, Berrn, Switzerland
    Circulation 107:5-9. 2003
  57. ncbi Direct en face imaging of secundum atrial septal defects by velocity-encoded cardiovascular magnetic resonance in patients evaluated for possible transcatheter closure
    Louise E J Thomson
    Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC 27710, USA
    Circ Cardiovasc Imaging 1:31-40. 2008
    ..Imaging the secundum ASD en face could potentially enable direct flow measurement and provide valuable information about ASD size, shape, location, and proximity to other structures...
  58. ncbi Resolution of right heart enlargement after closure of secundum atrial septal defect with transcatheter technique
    H W Kort
    Division of Cardiology, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri 63110, USA
    J Am Coll Cardiol 38:1528-32. 2001
    ..Decrease in RA area is inversely proportional to age at time of ASD closure. Long-term follow-up is required to evaluate the clinical impact of persistently increased RA size...
  59. ncbi Percutaneous, minimally invasive retrieval of a dislodged and impacted device from the abdominal aorta, four months after closure of an atrial septal defect
    Philipp Wagdi
    Department of Cardiology, HerzZentrum Hirslanden, Zurich, Switzerland
    Am J Cardiol 102:1111-2. 2008
    ..In conclusion, this case confirms that bouts of elevated intrathoracic pressure can lead to device dislocation and that it may be possible to successfully retrieve a device percutaneously, even months after implantation...
  60. ncbi Excellent survival and low incidence of arrhythmias, stroke and heart failure long-term after surgical ASD closure at young age. A prospective follow-up study of 21-33 years
    J W Roos-Hesselink
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Heart J 24:190-7. 2003
    ..Most studies were performed only by questionnaire and in a retrospective manner. The long-term outcome is very important with regard to future employment and acceptance on insurance schemes...
  61. ncbi Atrial septal defects type II: noninvasive evaluation of patients before implantation of an Amplatzer Septal Occluder and on follow-up by magnetic resonance imaging compared with TEE and invasive measurement
    Christoph Weber
    Diagnostic Center, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur Radiol 18:2406-13. 2008
    ..01) and MRI vs. IVBM was R = 0.77 (P < 0.01). Right ventricular volumes decreased after intervention. MRI is an accurate noninvasive test for diagnosis, planning and follow-up after interventional ASD occlusion using an AOC...
  62. ncbi Quantitative evaluation of the changes in plasma concentrations of cardiac natriuretic peptide before and after transcatheter closure of atrial septal defect
    H Muta
    Department of Pediatrics, Kurume University School of Medicine, Japan
    Acta Paediatr 91:649-52. 2002
    ..05). As with ANP, the concentrations gradually decreased to values not different from control values at 3 mo after the procedure (12 +/- 6.3 ng 1(-1), p = ns)...
  63. ncbi Efficacy of clopidogrel in the treatment of post-ASD closure migraines
    Mohsen Sharifi
    Catheter Cardiovasc Interv 63:255. 2004
  64. ncbi Myocardial ischemia induced by anomalous aortic origin of the right coronary artery in a patient with atrial septal defect
    F Maki
    Second Department of Internal Medicine, Ehime University School of Medicine, Japan
    Jpn Heart J 42:371-6. 2001
    ..In view of these findings, we suggest that an active combination treatment such as CABG and ASD closure is highly successful in a patient with a threatening coronary anomaly and congenital heart disease...
  65. ncbi Masked left ventricular restriction in elderly patients with atrial septal defects: a contraindication for closure?
    P Ewert
    Abteilung für Angeborene Herzfehler, Deutsches Herzzentrum Berlin, Berlin, Germany
    Catheter Cardiovasc Interv 52:177-80. 2001
    ..In the elderly, an atrial septal defect can have a decompressive impact on the left ventricle. Therefore, caution appears to be warranted if atrial septal closure is planned...
  66. ncbi Association of interatrial shunts and migraine headaches: impact of transcatheter closure
    Babak Azarbal
    Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
    J Am Coll Cardiol 45:489-92. 2005
    ....
  67. ncbi Platypnea-orthodeoxia syndrome: a report of two cases
    C Timmermans
    Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Cardiol 48:583-90. 1993
    ..The other case illustrates that, despite actual technical possibilities, clinical suspicion remains a prerequisite for proper diagnosis of the entity...
  68. ncbi Improvements in cardiac form and function after transcatheter closure of secundum atrial septal defects
    Omid Salehian
    Toronto Congenital Center for Adults and Echocardiography Laboratory, University of Toronto, Ontario, Canada
    J Am Coll Cardiol 45:499-504. 2005
    ..We set out to study the effect of transcatheter closure of atrial septal defect (ASD) on right ventricular (RV) and left ventricular (LV) function assessed by myocardial performance index (MPI), as well as left atrial (LA) volumes...
  69. ncbi Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects
    Maximilian G Posch
    Charite Universitatsmedizin Berlin, Cardiology at Campus Buch and Helios Klinikum Berlin Buch and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Am J Med Genet A 146:251-3. 2008
  70. ncbi Comparison between phase-velocity cine magnetic resonance imaging and invasive oximetry for quantification of atrial shunts
    Andrew J Powell
    Department of Cardiology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Am J Cardiol 91:1523-5, A9. 2003
  71. ncbi Surgical closure of patent foramen ovale in cryptogenic stroke patients
    S Homma
    Department of Medicine, Columbia University, New York, NY, USA
    Stroke 28:2376-81. 1997
    ..This report reviews our experience with cryptogenic stroke patients with PFO who underwent surgical PFO closure and were followed for recurrence of neurological events...
  72. ncbi Alpha-cardiac actin mutations produce atrial septal defects
    Hans Matsson
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University and University Hospital, S 75185 Uppsala, Sweden
    Hum Mol Genet 17:256-65. 2008
    ..The combined results indicate, for the first time, that ACTC1 mutations or reduced ACTC1 levels may lead to ASD without signs of cardiomyopathy...
  73. pmc Indications for the closure of patent foramen ovale
    Michael J Landzberg
    Boston Adult Congenital Heart Service, Department of Cardiology, Children s Hospital and Brigham and Women s Hospital, Boston, MA 02115, USA
    Heart 90:219-24. 2004
  74. ncbi Effect of surgical repair of secundum-type atrial septal defect on right atrial, right ventricular, and left ventricular volumes in adults
    J Shaheen
    Department of Cardiology, Jesselson Heart Center, Jerusalem, Israel
    Am J Cardiol 86:1395-7, A6. 2000
    ..Surgical repair of atrial septal defect in adults reduces right ventricular and right atrial diameters and volumes, and improves left ventricular filling...
  75. ncbi Early electrical and geometric changes after percutaneous closure of large atrial septal defect
    Giuseppe Santoro
    Division of Pediatric Cardiology, A O Monaldi, 2nd University of Naples, Naples, Italy
    Am J Cardiol 93:876-80. 2004
    ..In conclusion, regardless of age at procedure, percutaneous ASD closure results in early striking electrical and geometric cardiac changes that may be beneficial during long-term follow-up...
  76. ncbi Long-term impact of transcatheter atrial septal defect closure in adults on cardiac function and exercise capacity
    Alessandro Giardini
    Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy
    Int J Cardiol 124:179-82. 2008
    ..The long-term impact of transcatheter atrial septal defect (ASD) closure on right ventricular (RV) remodeling and exercise capacity is unknown...
  77. ncbi Acute left ventricular failure after transcatheter closure of a secundum atrial septal defect in a patient with coronary artery disease: a critical reappraisal
    Fabrizio Tomai
    Divisione di Cardiochirurgia, Universita di Roma Tor Vergata, European Hospital, Rome, Italy
    Catheter Cardiovasc Interv 55:97-9. 2002
    ..Transcatheter closure of atrial septal defects should always be deferred in ischemic heart disease patients who need percutaneous myocardial revascularization...
  78. ncbi Magnetic resonance imaging to assess acute changes in atrial and ventricular parameters after transcatheter closure of atrial septal defects
    Christof Burgstahler
    Cardiology Division, Department of Internal Medicine III, University of Tubingen, Tubingen, Germany
    J Magn Reson Imaging 25:1136-40. 2007
    ..To evaluate acute changes in atrial and ventricular parameters by the use of cardiac magnetic resonance imaging (MRI) in patients with percutaneous transcatheter atrial septal defects (ASD) closure...
  79. ncbi [3D-transthoracic echocardiography: a selection method prior to percutaneous closure of atrial septal defects]
    P Acar
    Service de Cardiologie Pediatrique, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris
    Arch Mal Coeur Vaiss 95:405-10. 2002
    ..This prospective study demonstrates that 9 out of 10 patients who had the 3D criteria had a percutaneous closure of the septal defect...
  80. pmc Transcatheter closure of atrial septal defects improves right ventricular volume, mass, function, pulmonary pressure, and functional class: a magnetic resonance imaging study
    S P Schoen
    Department of Cardiology, University of Dresden, Dresden, Germany
    Heart 92:821-6. 2006
    ....
  81. ncbi [Percutaneous catheter closure of atrial septal defect. Short-term and mid-term results]
    Jacek Bialkowski
    Servicio de Cardiopatías Congénitas y Cardiología Pediátrica Centro Silesiano de Enfermedades Cardíacas Academia Silesiana de Medicina Zabrze Poland
    Rev Esp Cardiol 56:383-8. 2003
    ..Percutaneous closure of atrial septal defects (ASD) is becoming more frequent...
  82. ncbi Interatrial septostomy under transesophageal echocardiography guidance: a novel approach
    Aman Mahajan
    Department of Anesthesiology, University of California at Los Angeles School of Medicine, 90095, USA
    J Thorac Cardiovasc Surg 123:824-6. 2002
  83. ncbi Transcatheter closure of atrial septal defect without balloon sizing
    Jou Kou Wang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Catheter Cardiovasc Interv 71:214-21. 2008
    ..To evaluate the safety and feasibility of transcatheter closure of atrial septal defect (ASD) without balloon sizing...
  84. ncbi Transesophageal echocardiography through nasal way as a guide to percutaneous closure of patent foramen ovale
    Demetrio Tallarico
    II Division of Cardiology, Department of the Heart and Great Vessels, University La Sapienza, Via R Zandonai 86, 00194 Rome, Italy
    Echocardiography 23:790-2. 2006
    ..TEENW might offer a feasible and equivalent echocardiographic alternative either to standard TEE or ICE as a guide to percutaneous PFO closure...
  85. ncbi Device closure rates of simple atrial septal defects optimized by the STARFlex device
    Alan W Nugent
    Department of Cardiology, Children s Hospital Boston, and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:538-44. 2006
    ..This study sought to review the outcomes of 3 generations of closure devices for secundum atrial septal defects (ASDs) at a single institution...
  86. ncbi Open-chest device closure for the minimally invasive management of atrial septal defect in young children
    Hao Zhang
    Center for Pediatric Surgery, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Heart Surg Forum 10:E125-8. 2007
    ..We integrated a catheter-based device and minimally invasive surgical techniques for the treatment of atrial septal defect for children younger than 2 years old...
  87. ncbi Transcatheter patent foramen ovale closure using the Premere PFO occlusion system
    Andrea Donti
    Pediatric Cardiology and Adult Congenital Unit, Institute of Cardiology, University of Bologna, Italy
    Catheter Cardiovasc Interv 68:736-40. 2006
    ..To evaluate the safety and efficacy profile of the new Premere patent foramen ovale (PFO) occlusion system...
  88. ncbi Dynamic contrast-enhanced MRI before and after transcatheter occlusion of patent foramen ovale
    Oliver K Mohrs
    Darmstadt Radiology, Department of Cardiovascular Imaging at Alice Hospital, Dieburger Strasse 29 31, 64287 Darmstadt, Germany
    AJR Am J Roentgenol 188:844-9. 2007
    ....
  89. ncbi Transcatheter closure of intracardiac defects in adults
    Michael S Kim
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    J Interv Cardiol 20:524-45. 2007
    ..This review will focus on the anatomy, pathophysiology, and current transcatheter therapeutic options for adult patients with patent foramen ovale (PFO), atrial septal defects (ASD), and ventricular septal defects (VSD)...
  90. ncbi Transcatheter closure of large atrial septal defects in 18 patients
    Zhanjun Guan
    Division of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Clin Cardiol 31:24-7. 2008
    ..This study was designed to evaluate the efficacy and safety of transcatheter closure of large atrial septal defects (ASD)...
  91. ncbi Left ventricular-right atrial communication complicated by aortic regurgitation
    Toru Okamura
    Department of Cardiovascular Surgery, Tokyo Women s Medical University, Tokyo
    Asian Cardiovasc Thorac Ann 16:e1-3. 2008
    ..We performed plication of the aortic valve and patch closure of the left ventricular-right atrial communication under cardiopulmonary bypass. The patient improved immediately after the operation...
  92. doi Acquired right-to-left shunt through an atrial septal perforation with cyanosis after percutaneous transvenous mitral commissurotomy
    Masakazu Nakao
    Department of Cardiothoracic Surgery, National Heart Centre, Singapore
    J Thorac Cardiovasc Surg 135:690-1. 2008
  93. ncbi An arrhythmic storm: a potential complication on opening the umbrella for percutaneous closure of interatrial communications
    Michele Coceani
    Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Am J Cardiol 100:1181-3. 2007
    ..In conclusion, percutaneous transcatheter closure of ICs is more rapid and less invasive compared with surgery, but nevertheless may be associated with significant short-term morbidity...
  94. ncbi Resolution of migraine by transcatheter patent foramen ovale closure with Premere Occlusion System in a preliminary series of patients with previous cerebral ischemia
    Gianluca Rigatelli
    PFO Related Syndromes Management Program, Cardiovascular Diagnosis and Interventions Service, Rovigo General Hospital, Italy
    Catheter Cardiovasc Interv 70:429-33. 2007
    ..We present the results of transcatheter closure of PFO with the last generation Premere Occlusion System device in a preliminary series of young adults with migraine and previous cerebral ischemia...
  95. ncbi Contemporary clinical management of atrial septal defects in the adult
    Gianluca Rigatelli
    Rovigo General Hospital, Section of Congenital and Structural Heart Disease Interventions, Viale Tre Martiri, 45100 Rovigo, Italy
    Expert Rev Cardiovasc Ther 5:1135-46. 2007
    ....
  96. ncbi A modified Cook sheath for closure of a large secundum atrial septal defect
    Christian Spies
    Section of Cardiology, Rush University Medical Center, Chicago, Illinois, USA
    Catheter Cardiovasc Interv 70:286-9. 2007
    ..However, the initial case report was complicated by malfunction and longitudinal splitting of the sheath. We describe the successful use of a modified delivery sheath for closure of a large atrial septal defect with a deficient rim...
  97. ncbi Multiple Amplatzer septal occluder devices for multiple atrial communications: immediate and long-term follow-up results
    Sawsan M Awad
    Section of Pediatric Cardiology, Department of Pediatrics, University of Chicago Hospitals, Chicago, Illinois 60637, USA
    Catheter Cardiovasc Interv 70:265-73. 2007
    ..We report on the feasibility, effectiveness, and long-term outcome of transcatheter closure of multiple ASD's using multiple ASO devices...
  98. ncbi 28 years' experience with transatrial-transpulmonary repair of atrioventricular septal defect with tetralogy of Fallot
    Gerard J F Hoohenkerk
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Thorac Surg 85:1686-9. 2008
    ..The purpose of this study was to evaluate our results of atrioventricular septal defect and tetralogy of Fallot repair by transatrial-transpulmonary approaches...
  99. ncbi Crowded atrial septum
    Bernhard Meier
    Catheter Cardiovasc Interv 70:274-5. 2007
  100. ncbi Unusual atrial septal anatomy resulting in an interatrial chamber: the true triatrial heart?
    A J Javois
    The Heart Institute for Children, Advocate Hope Children s Hospital, Oak Lawn, IL 60453, USA
    Pediatr Cardiol 28:224-8. 2007
    ..Clot formation might lead to systemic embolization. Angiographic findings are correlated with echocardiographic findings. Embryology and treatment options are considered...
  101. ncbi Removal of a left atrial thrombus adherent to a patent foramen ovale occluder
    Peter Krieg
    Department of Cardiothoracic Surgery, Friedrich Schiller University Jena, Jena, Germany
    Ann Thorac Surg 83:1539-41. 2007
    ..In an emergency procedure, the device and the left atrial thrombus were removed, the septal defect was closed, and a coronary artery bypass grafting was performed. The patient was discharged from the hospital in stable condition...

Research Grants27

  1. Safety of repetitive TMS in chronic subcortical stroke
    Steven Cramer; Fiscal Year: 2006
    ..The long-term goal of these studies is to develop a safe and efficacious method for facilitating motor cortex function in order to improve motor status of patients with stroke-related weakness. ..
  2. Safety of Autologous Marrow Stromal Cells After Stroke
    Steven Cramer; Fiscal Year: 2005
    ..This study is a Phase I safety trial, and thus represents the first step in evaluating autologous MSC transfusion in this regard. ..
  3. RECOVERY FROM STROKE: A CLINICAL & FUNCTIONAL MRI STUDY
    Steven Cramer; Fiscal Year: 2003
    ..3) MGH-NMR Center (Charlestown, MA), located two miles from (1) and (2), is a pioneering fMRI center. ..
  4. Thrombophilia In Cryptogenic Stroke (THICK) Study
    JORGE KIZER; Fiscal Year: 2006
    ..Interactions among thrombophilias, thrombophilias and traditional cardiovascular risk factors, and thrombophilias and other potential cardiac sources of embolism will also be investigated. ..
  5. BRAIN ISCHEMIA AND AORTIC ATHEROMATA IN A POPULATION
    GEORGE PETTY; Fiscal Year: 2001
    ..The investigators state that the study will also determine if clinical trials aimed at primary and secondary stroke prevention in these patients are warranted, and if so, assist in their design. ..
  6. Consensus Conference Grant
    Kathryn Hassell; Fiscal Year: 2006
    ..abstract_text> ..
  7. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  8. Pediatric Thin-Film TiNi Catheter-Based Heart Valve
    Daniel Levi; Fiscal Year: 2005
    ..Phase II studies will focus on accelerated wear testing, long-term in vivo animal testing, and manufacturing issues. ..
  9. Senescense and cerebral oxygenation with acute anemia
    Thomas Floyd; Fiscal Year: 2005
    ..We propose to study the effect of AIA on cerebral oxygenation and cognition in young and aged spontaneously hypertensive rats. ..
  10. PAX3 REGULATION OF CARDIAC CONOTRUNCAL DEVELOPMENT
    Jonathan Epstein; Fiscal Year: 2008
    ..Aim 3 examines the role of neural crest during development of the conduction system, and specifically examines Pax3 regulation of DCT. [unreadable] [unreadable]..
  11. THE ROLE OF LYMPHOCYTES IN CEREBRAL ISCHEMIC INJURY
    Kyra Becker; Fiscal Year: 2004
    ....
  12. VENTRICULAR REMODELING IN HEART FAILURE
    Paul Grayburn; Fiscal Year: 2003
    ..abstract_text> ..
  13. ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMM
    Marco Di Tullio; Fiscal Year: 2003
    ..This study will be the first prospective cohort study to evaluate the role of multiple echocardiographic risk factors for ischemic stroke in a community of whites, blacks and Hispanics living in the same area. ..
  14. Functional MR in Ischemic Cardiomyopathy
    Paul Grayburn; Fiscal Year: 2007
    ..Despite its known clinical utility for assessing the mechanism and severity of MR, TEE is not currently included in STICH. ..
  15. Aortic, Cardiovascular Disease and Silent Brain Infarcts
    Marco Di Tullio; Fiscal Year: 2009
    ..The present application will help fill gaps in knowledge on silent brain infarcts and their risk factors in the elderly, and identify subjects at higher risk before a symptomatic stroke or other vascular event occurs. ..
  16. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2009
    ..Data derived from this study will be used to plan future trials of immunomodulation in patients with stroke. ..
  17. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  18. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  19. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  20. Molecular basis of vascular heterogenity and function
    Jonathan Epstein; Fiscal Year: 2008
    ..abstract_text> ..
  21. 2005 NNFF Consortium for NF1, NF2 and Schwannomatosis
    Jonathan Epstein; Fiscal Year: 2005
    ....
  22. NATURAL HISTORY AND TREATMENT OUTCOME IN BRAIN AVM
    JP MOHR; Fiscal Year: 2005
    ..The results are improving the prediction for short- and long-term outcome for embolization and surgery. ..
  23. Calorie Restriction Effects on Chromosomal Aberrations
    CHARLEEN MOORE; Fiscal Year: 2003
    ..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..
  24. LBX2 AND UROGENITAL DEVELOPMENT
    Jonathan Epstein; Fiscal Year: 2002
    ....
  25. WARFARIN ANTIPLATELET RECURRENT STROKE STUDY
    J Mohr; Fiscal Year: 2001
    ..An emergency notification system helps maintain patient safety. Through 24-Oct-1996 1603 patients have been recruited from 49 participating centers toward the 1,920 patient sample size. ..
  26. Hepatoma derived growth factor and vascular smooth muscle cell proliferation
    Allen D Everett; Fiscal Year: 2010
    ..We propose here to determine the mechanism regulating the activity of this protein to provide the basis for the future design of new drugs to treat cardiovascular disease. ..