aortic coarctation

Summary

Summary: Narrowing of the lumen of the aorta, caused by deformity of the aortic media.

Top Publications

  1. ncbi Palliative stent implantation for aortic coarctation in premature infants weighing <1,500 g
    Wolfgang A K Radtke
    Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Cardiol 90:1409-12. 2002
  2. ncbi Reoperation and coarctation of the aorta: the need for lifelong surveillance
    C Manganas
    The New Children s Hospital, Sydney, New South Wales, Australia
    Ann Thorac Surg 72:1222-4. 2001
  3. ncbi Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression
    Ram K Sindhu
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, USA
    Life Sci 76:945-53. 2005
  4. ncbi The influence of different surgical approaches on arterial rigidity in children after aortic coarctation repair
    Pier Paolo Bassareo
    Department of Cardiovascular and Neurologic Sciences, University of Cagliari, Policlinico Universitario, Monserrato, Cagliari, Italy
    Pediatr Cardiol 30:414-8. 2009
  5. ncbi Late complications in patients after repair of aortic coarctation: implications for management
    Joris W J Vriend
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Cardiol 101:399-406. 2005
  6. ncbi Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload
    Z Keshavarz-Motamed
    Mechanical and Industrial Engineering, Concordia University, Montreal, Canada
    J Biomech 44:2817-25. 2011
  7. ncbi Comparison of surgical, stent, and balloon angioplasty treatment of native coarctation of the aorta: an observational study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)
    Thomas J Forbes
    Children s Hospital of Michigan, Detroit, USA
    J Am Coll Cardiol 58:2664-74. 2011
  8. ncbi Aortic arch shape deformation after coarctation surgery: effect on blood pressure response
    Phalla Ou
    INSERM UMR_S678, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Thorac Cardiovasc Surg 132:1105-11. 2006
  9. ncbi Major vascular anomalies in Turner syndrome: prevalence and magnetic resonance angiographic features
    Vincent B Ho
    Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Circulation 110:1694-700. 2004
  10. ncbi Improved measurement of pressure gradients in aortic coarctation by magnetic resonance imaging
    J N Oshinski
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Coll Cardiol 28:1818-26. 1996

Detail Information

Publications271 found, 100 shown here

  1. ncbi Palliative stent implantation for aortic coarctation in premature infants weighing <1,500 g
    Wolfgang A K Radtke
    Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Cardiol 90:1409-12. 2002
  2. ncbi Reoperation and coarctation of the aorta: the need for lifelong surveillance
    C Manganas
    The New Children s Hospital, Sydney, New South Wales, Australia
    Ann Thorac Surg 72:1222-4. 2001
    We report a series of reoperations in 23 patients who had undergone previous aortic coarctation repair.
  3. ncbi Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression
    Ram K Sindhu
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, USA
    Life Sci 76:945-53. 2005
    Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in ..
  4. ncbi The influence of different surgical approaches on arterial rigidity in children after aortic coarctation repair
    Pier Paolo Bassareo
    Department of Cardiovascular and Neurologic Sciences, University of Cagliari, Policlinico Universitario, Monserrato, Cagliari, Italy
    Pediatr Cardiol 30:414-8. 2009
    ..or secondary hypertension, probably related to the loss of arterial elasticity, frequently occur after aortic coarctation surgery...
  5. ncbi Late complications in patients after repair of aortic coarctation: implications for management
    Joris W J Vriend
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Cardiol 101:399-406. 2005
    Survival of patients with aortic coarctation has dramatically improved after surgical repair became available and the number of patients who were operated and reach adulthood is steadily increasing...
  6. ncbi Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload
    Z Keshavarz-Motamed
    Mechanical and Industrial Engineering, Concordia University, Montreal, Canada
    J Biomech 44:2817-25. 2011
    ..This model can be used to optimize the management of patients with COA and AS in terms of the sequence of lesion repair...
  7. ncbi Comparison of surgical, stent, and balloon angioplasty treatment of native coarctation of the aorta: an observational study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)
    Thomas J Forbes
    Children s Hospital of Michigan, Detroit, USA
    J Am Coll Cardiol 58:2664-74. 2011
    ..The purpose of this study was to compare the safety and efficacy of surgical, stent, and balloon angioplasty (BA) treatment of native coarctation acutely and at follow-up...
  8. ncbi Aortic arch shape deformation after coarctation surgery: effect on blood pressure response
    Phalla Ou
    INSERM UMR_S678, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Thorac Cardiovasc Surg 132:1105-11. 2006
    ..We sought to investigate the effect of particular deformations of aortic arch shape on blood pressure response in children who had undergone successful repair of coarctation of the aorta...
  9. ncbi Major vascular anomalies in Turner syndrome: prevalence and magnetic resonance angiographic features
    Vincent B Ho
    Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Circulation 110:1694-700. 2004
    Turner syndrome (TS) is associated with aortic coarctation and dissection; hence, echocardiographic evaluation of all patients is currently recommended...
  10. ncbi Improved measurement of pressure gradients in aortic coarctation by magnetic resonance imaging
    J N Oshinski
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Coll Cardiol 28:1818-26. 1996
    This study evaluated whether magnetic resonance imaging (MRI) and magnetic resonance (MR) phase velocity mapping could provide accurate estimates of stenosis severity and pressure gradients in aortic coarctation.
  11. ncbi Transverse arch hypoplasia may predispose patients to aneurysm formation after patch repair of aortic coarctation
    Thomas S Maxey
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 76:1090-3. 2003
    Thoracic aortic aneurysm after patch repair of aortic coarctation is a potentially lethal complication. We hypothesized that transverse arch hypoplasia in association with patch repair of aortic coarctation predisposes aneurysm formation.
  12. ncbi Recurrent coarctation: is surgical repair of recurrent coarctation of the aorta safe and effective?
    John W Brown
    Section of Cardiothoracic Surgery, James W Riley Hospital for Children, Indianapolis, Indiana 46202 5123, USA
    Ann Thorac Surg 88:1923-30; discussion 1930-1. 2009
    ..We reviewed our experience with surgical repair of recurrent coarctation of the aorta and compared it with our institutional experience with balloon aortoplasty...
  13. ncbi Heterogeneity of ventricular repolarization in newborns with severe aortic coarctation
    Gerardo Nigro
    Second University of Naples, Monaldi Hospital, Naples, Italy
    Pediatr Cardiol 33:302-6. 2012
    Sudden death is a possible occurrence for newborns younger than 1 year with severe aortic coarctation (CoA) before surgical correction...
  14. ncbi Doppler echocardiographic profile and indexes in the evaluation of aortic coarctation in patients before and after stenting
    Ju Le Tan
    Adult Congenital Heart Disease Unit, Royal Brompton Hospital, London, United Kingdom
    J Am Coll Cardiol 46:1045-53. 2005
    We sought to assess the effect of successful stenting on the Doppler profile of aortic coarctation and to identify echocardiographic indexes that could be used for follow-up of such patients.
  15. ncbi Ambulatory blood pressure, left ventricular mass, and conduit artery function late after successful repair of coarctation of the aorta
    Marcello de Divitiis
    Vascular Physiology Unit, Great Ormond Street Hospital for Children NHS Trust and the Institute of Child Health, London, United Kingdom
    J Am Coll Cardiol 41:2259-65. 2003
    ....
  16. pmc Prevalence of hypertension in children after early repair of coarctation of the aorta: a cohort study using casual and 24 hour blood pressure measurement
    J J O'Sullivan
    Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, UK
    Heart 88:163-6. 2002
    ..To study the prevalence of hypertension in a cohort of patients using the current strategy of repair in early childhood...
  17. ncbi Angular (Gothic) aortic arch leads to enhanced systolic wave reflection, central aortic stiffness, and increased left ventricular mass late after aortic coarctation repair: evaluation with magnetic resonance flow mapping
    Phalla Ou
    INSERM UMR_S678, CHU la Pitié Salpétrière, Paris, France
    J Thorac Cardiovasc Surg 135:62-8. 2008
    We sought to investigate the mechanism whereby a particular deformity of the aortic arch, an angulated Gothic shape, might lead to hypertension late after anatomically successful repair of aortic coarctation.
  18. ncbi Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair
    Phalla Ou
    Department of Pediatric Radiology, Hopital Necker Enfants Malades, University Rene Descartes Paris 5, Paris, France
    Am Heart J 155:187-93. 2008
    Hypertension occurs in 20% to 40% of survivors of anatomically successful repair of aortic coarctation (CoA). The aim of the present study was to examine the role of central aortic function in this setting.
  19. ncbi Diagnostic and surgical trends, and epidemiology of coarctation of the aorta in a population-based study
    V Grech
    Paediatric Department, St Luke s Hospital, Guardamangia, Malta
    Int J Cardiol 68:197-202. 1999
    ..In conclusion, in Malta, coarctation of the aorta has been diagnosed and treated safely, at progressively younger ages, and this has been attributed to improving medical services over the period under study...
  20. ncbi Late systemic hypertension and aortic arch geometry after successful repair of coarctation of the aorta
    Phalla Ou
    Cardiologie Pediatrique, Department of Pediatrics, Hopital Necker Enfants Malades, AP HP, 149, rue de Sevres, 75015 Paris, France
    Eur Heart J 25:1853-9. 2004
    ..To investigate the role of the geometry of the aortic arch in resting hypertension after successful repair of coarctation (CoA)...
  21. ncbi Results and mid-long-term follow-up of stent implantation for native and recurrent coarctation of the aorta
    Massimo Chessa
    Pediatric Cardiology Department and Adult with Congenital Heart Disease, GUCH Unit, Policlinico San Donato, San Donato M se, Milan, Italy
    Eur Heart J 26:2728-32. 2005
    ..In the last decades, stent implantation has been proposed as a reliable option for the treatment of coarctation of the aorta. In this setting, it seems to have some advantages, rendering it superior to angioplasty alone...
  22. ncbi Acute and intermediate outcomes, and evaluation of injury to the aortic wall, as based on 15 years experience of implanting stents to treat aortic coarctation
    Athar M Qureshi
    Department of Cardiology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Cardiol Young 17:307-18. 2007
    Stenting for aortic coarctation has been shown to be effective in the short term...
  23. ncbi Repair of aortic coarctation using temporary ascending to descending aortic bypass in children with poor collateral circulation
    Jan T Christenson
    Department of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    Cardiol Young 14:39-45. 2004
    b>Aortic coarctation can now be repaired surgically with excellent results. Even though rare, injury to the spinal cord resulting in paraplegia remains a major concern...
  24. ncbi A new approach for the evaluation of the severity of coarctation of the aorta using Doppler velocity index and effective orifice area: in vitro validation and clinical implications
    Z Keshavarz-Motamed
    Mechanical and Industrial Engineering, Concordia University, Montreal, Canada
    J Biomech 45:1239-45. 2012
    ..As a conclusion, COA Doppler velocity index and COA effective orifice area are flow independent and do not depend on aortic valve conditions. They can, then, more accurately predict the severity of COA...
  25. ncbi Scoliosis in patients with aortic coarctation and patent ductus arteriosus: does standard posterolateral thoracotomy play a role in the development of the lateral curve of the spine?
    Marek Roclawski
    Department of Orthopaedics, Medical University of Gdansk, Nowe Ogrody 1 6, 80 803 Gdansk, Poland
    Pediatr Cardiol 30:941-5. 2009
    ..The rate of scoliosis after thoracotomy is higher in male than female patients, especially after thoracotomy for PDA...
  26. ncbi Infective endocarditis-endarteritis complicating coarctation of the aorta
    Carlos Franco-Paredes
    Am J Med 112:590-2. 2002
  27. ncbi Surgical treatment of atypical aortic coarctation complicating Takayasu's arteritis--experience with 33 cases over 44 years
    Tsuyoshi Taketani
    Department of Cardiothoracic Surgery, and Division of Vascular Surgery, Graduate School of Medicine, The University of Tokyo, Japan
    J Vasc Surg 41:597-601. 2005
    This study was conducted to evaluate the long-term outcomes of surgical treatment for atypical aortic coarctation due to Takayasu's arteritis and to elucidate the factors that affected outcome.
  28. ncbi [Endovascular treatment of long-term complications following surgical repair of aortic coarctation]
    Pablo Garcia-Pavia
    Servicio de Cardiología Hospital Universitario Puerta de Hierro Madrid España
    Rev Esp Cardiol 63:473-7. 2010
    Surgical treatment of aortic coarctation has a high success rate. However, irrespective of the surgical technique used, a significant percentage of patients develop late complications affecting the aortic wall...
  29. ncbi Effectiveness and safety of balloon dilation of native aortic coarctation in premature neonates weighing < or = 2,500 grams
    Abraham Rothman
    Children s Heart Center Nevada, Las Vegas, Nevada, USA
    Am J Cardiol 105:1176-80. 2010
    ..Some patients will have a successful long-term result after a single balloon dilation procedure. However, restenosis is common and tends to develop rapidly...
  30. ncbi MR findings of collateral circulation are more accurate measures of hemodynamic significance than arm-leg blood pressure gradient after repair of coarctation of the aorta
    Philip A Araoz
    Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    J Magn Reson Imaging 17:177-83. 2003
    ....
  31. ncbi Endovascular stent placement is an acceptable alternative to reoperation in selected infants with residual or recurrent aortic arch obstruction
    Jamie Bentham
    Department of Paediatric Cardiology and Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, United Kingdom
    Catheter Cardiovasc Interv 76:852-9. 2010
    ..To describe endovascular stent placement in infants as a technically feasible option in circumstances where surgery is considered less favorable...
  32. pmc Computational simulations for aortic coarctation: representative results from a sampling of patients
    John F LaDisa
    Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53233, USA
    J Biomech Eng 133:091008. 2011
    ..These results apply CFD to a range of CoA patients for the first time and provide the foundation for future progress in this area...
  33. pmc Outcome after extended arch repair for aortic coarctation
    J D R Thomson
    Department of Congenital Cardiology, Yorkshire Heart Centre, Leeds General Infirmary, Leeds, UK
    Heart 92:90-4. 2006
    ..To assess survival and long term arch patency rates in a consecutive group of children after extended arch repair for coarctation of the aorta...
  34. ncbi Association between fetal lymphedema and congenital cardiovascular defects in Turner syndrome
    Melissa L Loscalzo
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 115:732-5. 2005
    ..is associated with congenital cardiovascular defects (CCVDs), most commonly bicuspid aortic valve (BAV) and aortic coarctation (COARC), congenital renal anomalies, and fetal lymphedema...
  35. ncbi Repair of coarctation of the aorta in infants weighing less than 2 kilograms
    Catherine D Sudarshan
    Cardiac Surgery Unit, Royal Children s Hospital, Parkville, Victoria, Australia
    Ann Thorac Surg 82:158-63. 2006
    We retrospectively reviewed our experience in aortic coarctation repair on infants weighing less than 2 kg to evaluate the results and assess the rate of recoarctation in this group of patients.
  36. ncbi Aortic arch geometry and exercise-induced hypertension in aortic coarctation
    Enrico De Caro
    Cardiovascular Department, Scientific Directorate, Istituto Giannina Gaslini Children s Hospital, Genoa, Italy
    Am J Cardiol 99:1284-7. 2007
    Hypertension at rest or during effort is not uncommon in patients with aortic coarctation (CoA), even those with a successful repair or mild degree of obstruction...
  37. ncbi Coarctation repair in neonates and young infants: is small size or low weight still a risk factor?
    Phillip T Burch
    Division of Cardiothoracic Surgery, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah, USA
    J Thorac Cardiovasc Surg 138:547-52. 2009
    ..This study assesses the effect of patient size on reintervention and survival in neonates and infants undergoing repair of simple aortic coarctation.
  38. ncbi Severe aortic coarctation in infants less than 3 months: successful palliation by balloon angioplasty
    P Syamasundar Rao
    Division of Pediatric Cardiology, UT Houston Medical School, 6431 Fannin, Suite 3 132, Houston, TX 77030, USA
    J Invasive Cardiol 15:202-8. 2003
    The optimal management strategy of the neonate and young infant with native aortic coarctation (AC) is controversial...
  39. ncbi Factors affecting long-term risk of aortic arch recoarctation after the Norwood procedure
    Traci M Ashcraft
    Division of Cardiothoracic Surgery, The Heart Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Ann Thorac Surg 85:1397-401; discussion 1401-2. 2008
    ..The purpose of this study was to identify factors predicting risk of aortic arch recoarctation after the Norwood procedure...
  40. ncbi Extended resection and end-to-end anastomosis for aortic coarctation in infants: results of a tailored surgical approach
    Gail E Wright
    Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Ann Thorac Surg 80:1453-9. 2005
    The surgical repair of aortic coarctation in infants has evolved over time. This study evaluates our current approach utilizing extended end-to-end anastomosis without prosthetic material to enlarge all areas of aortic arch hypoplasia.
  41. ncbi Mortality and restenosis rate of surgical coarctation repair in infancy: a study of 191 patients
    Alfred Hager
    Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Munchen, Germany
    Cardiology 112:36-41. 2009
    This is a retrospective cross-sectional study to analyze mortality and the rate of restenosis in the follow-up of patients after surgical repair of isolated aortic coarctation in infancy.
  42. ncbi Impact of re-coarctation following the Norwood operation on survival in the balloon angioplasty era
    Ilana Zeltser
    Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 45:1844-8. 2005
    ..The objective of this study was to determine the efficacy of balloon angioplasty (BA) by comparing the immediate and long-term outcomes of patients with and without re-coarctation after a Norwood procedure...
  43. ncbi Comparison of surgical and transcatheter treatment for native coarctation of the aorta in patients > or = 1 year old. The Quebec Native Coarctation of the Aorta study
    Josep Rodes-Cabau
    Quebec Heart Institute Laval Hospital, Quebec, Quebec, Canada
    Am Heart J 154:186-92. 2007
    ..The objectives of this study were to compare, in the current era, the immediate results, complications, and midterm outcomes obtained by surgical repair versus transcatheter treatment of coarctation of the aorta (CoA)...
  44. ncbi MR imaging of aortic coarctation
    F Secchi
    Servizio di Radiologia, Dipartimento di Scienze Medico Chirurgiche, Universita degli Studi di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Italy
    Radiol Med 114:524-37. 2009
    b>Aortic coarctation accounts for 5%-10% of all congenital heart diseases and represents 7% of critically ill infants with heart disease...
  45. ncbi Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation
    Randall T Peterson
    Nat Biotechnol 22:595-9. 2004
    ..grl, affecting the gene hey2) disrupts aortic blood flow in a region and physiological manner akin to aortic coarctation in humans...
  46. ncbi Abdominal aortic coarctation: surgical treatment of 53 patients with a thoracoabdominal bypass, patch aortoplasty, or interposition aortoaortic graft
    James C Stanley
    Department of Surgery, Section of Vascular Surgery, University of Michigan Cardiovascular Center, Ann Arbor, MI 48109 5867, USA
    J Vasc Surg 48:1073-82. 2008
    Abdominal aortic coarctation is uncommon and often complicated with coexisting splanchnic and renal artery occlusive disease...
  47. ncbi Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy: a prospective, multicenter experience
    Sarah Tabbutt
    Cardiac Intensive Care Unit, The Cardiac Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Thorac Cardiovasc Surg 136:1229-36. 2008
    ....
  48. ncbi Risk factors for aortic complications in adults with coarctation of the aorta
    Jose Maria Oliver
    Adult Congenital Heart Disease Unit, Radiology Department, La Paz University Hospital, Castellana 261, 28046 Madrid, Spain
    J Am Coll Cardiol 44:1641-7. 2004
    ..We sought to determine the prevalence and predisposing condition for aortic wall complications in adults with either repaired or non-repaired coarctation of the aorta...
  49. ncbi Subclavian flap repair: review of 399 patients at median follow-up of fourteen years
    Ragini Pandey
    Department of Cardiology and Cardiac Surgery, Royal Liverpool Children s NHS Trust, Liverpool, United Kingdom
    Ann Thorac Surg 81:1420-8. 2006
    ..The purpose of this study was to assess the results of subclavian flap aortoplasty (SFA) alone, performed on 399 patients in a single institute between 1966 and 1995...
  50. ncbi Intermediate term follow-up of the end-to-side aortic anastomosis for coarctation of the aorta
    Adel K Younoszai
    Division of Pediatric Cardiology, University of California San Francisco, USA
    Ann Thorac Surg 74:1631-4. 2002
    ..By connecting the descending aorta to the proximal aortic arch, the end-to-side aortic anastomosis isolates hypoplastic distal arch and encroaching ductal tissue from the anastomotic site...
  51. ncbi Endovascular stent-graft repair of late pseudoaneurysms after surgery for aortic coarctation
    Burkhart Zipfel
    Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany
    Ann Thorac Surg 91:85-91. 2011
    ..We analyzed the potential of endovascular stent grafts to treat late aortic pseudoaneurysms after coarctation repair...
  52. ncbi Underrecognition of elevated blood pressure readings in children after early repair of coarctation of the aorta
    Christopher Gillett
    Bristol Congenital Heart Centre, Bristol Royal Hospital for Children, Bristol, BS6 7UB, UK
    Pediatr Cardiol 32:202-5. 2011
    ..When elevated BP is documented, in all cases no recorded action was taken. This may have significant implications for cardiovascular outcomes in this cohort of patients...
  53. ncbi Complex aortic coarctation and PHACE syndrome
    Fredy Prada
    Servicio de Cardiologia, Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain
    Rev Esp Cardiol 63:1367-70. 2010
    ..We report our findings in four patients with this syndrome, in whom it was characterized by complex aortic coarctation that required not only preoperative echocardiographic investigation, but also the use of techniques such as ..
  54. ncbi Multimodal neuromonitoring in a patient with aneurysmal subarachnoid hemorrhage associated with aortic coarctation
    Raimund Helbok
    Neurological Intensive Care Unit, Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neurocrit Care 14:433-7. 2011
    b>Aortic coarctation (AC) rarely remains undiagnosed until adulthood. Intracranial aneurysms and spontaneous subarachnoid hemorrhage (SAH) are more frequent in patients with AC than in the general population.
  55. ncbi Reverse subclavian flap repair of hypoplastic transverse aorta in infancy
    K R Kanter
    Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann Thorac Surg 71:1530-6. 2001
    ..Management of hypoplastic aortic arch associated with coarctation in infancy can be challenging. Reverse subclavian flap aortoplasty plus coarctation resection offers simplicity without needing foreign material or cardiopulmonary bypass...
  56. ncbi Aortic hemodynamics in patients with and without repair of aortic coarctation: in vivo analysis by 4D flow-sensitive magnetic resonance imaging
    Alex Frydrychowicz
    Department of Radiology, Medical Physics, University Hospital Freiburg, Germany
    Invest Radiol 46:317-25. 2011
    ..purpose of this study was to characterize hemodynamic alterations and flow-derived vessel wall parameters in aortic coarctation (CoA) patients with and without operative repair by time-resolved, 3-dimensional, and 3-directional velocity ..
  57. ncbi Partial anomalous left pulmonary artery along with aortic coarctation in an infant with Kabuki syndrome
    Aarti H Bhat
    Division of Pediatric Cardiology, Seattle Children s Hospital, University of Washington, Seattle, Washington 98105, USA
    Echocardiography 29:E145-7. 2012
    ..While coarctation and hypoplastic left heart syndrome are observed in this syndrome, this is the second reported case of aLPA in KS and the first with the forme fruste of left-sided obstruction as well as aLPA in this group of patients...
  58. ncbi Abnormal responses for blood pressure in children and adults with surgically corrected aortic coarctation
    M Hauser
    Deutsches Herzzentrum, Department of Paediatric Cardiology, Munich, Germany
    Cardiol Young 10:353-7. 2000
    Despite successful surgical repair of aortic coarctation, life expectancy is reduced, and up to one-third of patients remain or become hypertensive...
  59. pmc Factors associated with subsequent arch reintervention after initial balloon aortoplasty in patients with Norwood procedure and arch obstruction
    Diego Porras
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 58:868-76. 2011
    ....
  60. ncbi Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood
    Paul Luijendijk
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Am J Cardiol 108:435-9. 2011
    ....
  61. ncbi Prediction of recurrent coarctation by early postoperative blood pressure gradient
    T K Susheel Kumar
    Department of Cardiovascular Surgery, Children s National Medical Center, Washington, DC 20010, USA
    J Thorac Cardiovasc Surg 142:1130-6, 1136.e1. 2011
    ..To define the predictive reliability of blood pressure gradients between arms and legs and to identify predictors of arch growth, we undertook a retrospective study...
  62. ncbi Functional null mutations in the gonosomal homologue gene TBL1Y are associated with non-syndromic coarctation of the aorta
    A Tagariello
    Institute of Human Genetics, University of Erlangen, Schwabachanlage 10, Erlangen, D 91054, Germany
    Curr Mol Med 12:199-205. 2012
    ..Several studies have shown that Notch signalling is important for proper development of the left ventricular outflow tract. Our findings suggest that TBL1Y is involved in the genesis of non-syndromic coarctation of the aorta...
  63. pmc Computational simulations demonstrate altered wall shear stress in aortic coarctation patients treated by resection with end-to-end anastomosis
    John F LaDisa
    Department of Biomedical Engineering, Marquette University, Children s Hospital and the Medical College of Wisconsin, 1515 West Wisconsin Avenue, Milwaukee, WI 53233, USA
    Congenit Heart Dis 6:432-43. 2011
    ..Resection with end-to-end anastomosis (RWEA) is the gold standard for coarctation of the aorta (CoA) repair, but may lead to altered WSS indices that contribute to morbidity...
  64. ncbi Late outcomes of reintervention on the descending aorta after repair of aortic coarctation
    Morgan L Brown
    Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 122:S81-4. 2010
    After repair of aortic coarctation, patients may develop restenosis, aneurysms, and pseudoaneurysms at the site of prior repair. We assessed the outcomes of late reintervention on the descending aorta after aortic coarctation repair.
  65. ncbi Noninvasive diagnosis of aortic coarctation in neonates with patent ductus arteriosus
    Chun Wei Lu
    Department of Pediatrics, Shin Kong Wu Ho Su Memorial Hospital, National Taiwan University, No 7 Chung Shan South Road, 100 Taipei, Taiwan
    J Pediatr 148:217-21. 2006
    ..To find a noninvasive method to detect coarctation of the aorta (CoA) in the presence of a patent ductus arteriosus (PDA) in neonates...
  66. ncbi Echocardiographic indices of Doppler flow patterns compared with MRI or angiographic measurements to detect significant coarctation of the aorta
    D Scott Lim
    Departmetn of Pediatric Cardiology, Michigan Congenital Heart Center, University of Michigan, Ann Arbor, MI, USA
    Echocardiography 19:55-60. 2002
    ..Systolic measurements of velocity or pressure half-times are not adequate to assess severity of CoA...
  67. ncbi Selective use of left heart bypass for aortic coarctation
    Andrew C Fiore
    Section of Cardiothoracic Surgery, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Ann Thorac Surg 89:851-6; discussion 856-7. 2010
    We evaluated left heart bypass (LHB) for spinal cord protection during aortic coarctation repair in patients with mild (primary, postsurgical, or intervention) and complex coarctation.
  68. ncbi Comparison of surgical and interventional therapy of native and recurrent aortic coarctation regarding different age groups during childhood
    Seraina Früh
    Division of Pediatric and Congenital Cardiac Surgery, University Children s Hospital Zurich, Zurich, Switzerland
    Eur J Cardiothorac Surg 39:898-904. 2011
    ..rate of complications and re-interventions during medium-term outcome in pediatric patients with native or recurrent aortic coarctation. We focused on an age-related therapeutic approach comparing surgical and trans-catheter treatment.
  69. ncbi Coarctation of the aorta presenting as cerebral hemorrhage
    Petra Susanne Mehwald
    Department of Pediatric Cardiology, University Hospital, Freiburg, Germany
    J Pediatr 146:293. 2005
  70. ncbi Carotid-subclavian artery index: new echocardiographic index to detect coarctation in neonates and infants
    Ali Dodge-Khatami
    Division of Cardiovascular Surgery, University Children s Hospital, Zurich, Switzerland
    Ann Thorac Surg 80:1652-7. 2005
    ..A reliable noninvasive screening tool for coarctation would be useful for these patients...
  71. ncbi Validation of two echocardiographic indexes to improve the diagnosis of complex coarctations
    Yvan Mivelaz
    Paediatric Cardiology, Cardiovascular and Metabolic Diseases Centre, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Eur J Cardiothorac Surg 34:1051-6. 2008
    ..It is highly suggestive of a coarctation when it is <1.5. The I/D ratio defined as the diameter of the isthmus to the diameter of the descending aorta, suggests an aortic coarctation when it is less than 0.64.
  72. ncbi Pseudoaneurysm complicating aortic coarctation in a pregnant woman
    Pablo Avanzas
    Int J Cardiol 97:157-8. 2004
  73. ncbi Polysplenia/heterotaxy syndrome associated with aortic coarctation and multiple venous anomalies: multidetector computed tomography findings
    Aysegul Karadeniz
    Department of Radiology, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
    Vasc Endovascular Surg 44:381-4. 2010
    ..We present a previously unreported association of aortic coarctation, double superior vena cava, a left-hand side inferior vena cava with hemiazygos vein continuation and a ..
  74. pmc Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertension
    Mariela M Gironacci
    Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Peptides 28:1580-5. 2007
    ..angiotensin (Ang) (1-7) injected into the brain blocked Ang II pressor actions in rats made hypertensive by aortic coarctation (CH), we examined systemic and tissue angiotensin peptide levels, specifically concentrating on the ..
  75. ncbi The results of catheter-based therapy compared with surgical repair of adult aortic coarctation
    John Alfred Carr
    Department of Cardiovascular and Thoracic Surgery, University of Chicago, Chicago, Illinois 60637, USA
    J Am Coll Cardiol 47:1101-7. 2006
    ..the results of endovascular therapy (stenting and angioplasty) with surgical techniques to repair adult aortic coarctation. The immediate improvement in hypertension and the morbidity were similar across all groups...
  76. ncbi Stents for correction of aortic coarctation in adults
    Ana M Teixeira
    Serviço de Cardiologia Pediátrica do Hospital de Santa Cruz, Carnaxide, Portugal
    Rev Port Cardiol 24:1559-63. 2005
  77. ncbi Aortic coarctation endarteritis and aneurysm: diagnosis by transoesophageal echocardiography
    J R Skinner
    Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, U K
    Int J Cardiol 34:216-8. 1992
    ..developed infective endarteritis, caused by Staphylococcus aureus, at the site of a previously undiagnosed aortic coarctation. Transoesophageal echocardiography revealed a clinically unsuspected false aneurysm...
  78. ncbi Technique of interventional repair in adult aortic coarctation
    Stephan Kische
    Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Rostock, Germany
    J Vasc Surg 51:1550-9. 2010
    Surgical treatment of aortic coarctation has increased life expectancy and reduced mortality...
  79. ncbi Successful long-term stenting of an atypical descending aortic coarctation
    Douglas Scott Keith
    Northwest Kaiser Permanente, PC, 6902 SE Lake Road, Suite 100, Milwaukie, OR 97267, USA
    J Vasc Surg 35:166-7. 2002
    ..Patency of the stent and control of the hypertension at 2 and a half years suggest that endovascular treatment of atypical coarctation may be successful with the use of mechanical stents and may be an alternative to surgical correction...
  80. ncbi Left internal mammary artery atherosclerosis: twenty-three years after repair of aortic coarctation
    Ahmad K Darwazah
    Department of Cardiac Surgery, Makassed Hospital, Jerusalem, Israel
    Ann Thorac Surg 86:1991-4. 2008
    ..describe a case in which a 41-year-old man underwent coronary artery bypass surgery 23 years after repair of aortic coarctation. The diseased mammary artery was used to graft the left anterior descending coronary artery after ..
  81. ncbi Covered-stent implantation to treat aortic coarctation
    Gianfranco Butera
    Department of Pediatric Cardiology and GUCH Unit, Policlinico San Donato IRCCS, Via Morandi, 30, 20097 San Donato Milanese, Italy
    Expert Rev Med Devices 9:123-30. 2012
    b>Aortic coarctation comprises approximately 7% of all known congenital heart defects...
  82. ncbi Left cervical aortic arch associated with aortic aneurysm, aortic coarctation, and branch artery aneurysm--a case report and review
    Osamu Tsukamoto
    Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Angiology 54:257-60. 2003
    ..Although, in CAA, other cardiovascular abnormalities including aortic aneurysm and aortic coarctation are occasionally accompanied, coexistence of those 2 aortic abnormalities on the same patient is rare, and ..
  83. ncbi The fate of systemic blood pressure in patients after effectively stented coarctation
    Andreas Eicken
    Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Munchen, Technische Universitat, Germany
    Eur Heart J 27:1100-5. 2006
    ..The current study was designed to assess midterm results of stent implantation into the aorta for native and recurrent coarctation (CoA) in children and young adults...
  84. ncbi Abdominal aortic pulsed wave Doppler patterns reliably reflect clinical severity in patients with coarctation of the aorta
    Suchaya Silvilairat
    Division of Pediatric Cardiology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Congenit Heart Dis 3:422-30. 2008
    ..There are situations in which standard echocardiography does not adequately define the aortic arch. We sought to determine what additional information could be gained by analyzing abdominal aortic Doppler flows in coarctation...
  85. ncbi Limitations of Doppler echocardiography for the post-operative evaluation of aortic coarctation
    S De Mey
    Hydraulics Laboratory, Institute of Biomedical Technology, Ghent University, St Pietersnieuwstraat 41, 9000, Ghent, Belgium
    J Biomech 34:951-60. 2001
    ..measurements and derived pressure differences, through the Bernoulli equation, are used in the diagnosis of aortic coarctation, a congenital stenosis distal to the left subclavian artery...
  86. ncbi Outcome of pregnancy in patients after repair of aortic coarctation
    Joris W J Vriend
    Department of Cardiology, Academic Medical Center, Room B2 240, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Eur Heart J 26:2173-8. 2005
    Nowadays, most women born with aortic coarctation reach childbearing age. However, data on outcome of pregnancy in women after repair of aortic coarctation are scarce...
  87. ncbi Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair
    Alfred Hager
    Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Munchen, Technische Universitat Munchen, Germany
    Int J Cardiol 151:63-8. 2011
    Even after repair of aortic coarctation without restenosis there is a high incidence of arterial hypertension...
  88. ncbi Muscle-sparing extrapleural approach for the repair of aortic coarctation
    Hitendu Hasmukhlal Dave
    Division of Congenital Cardiovascular Surgery, University Children s Hospital, Zurich, Switzerland
    Ann Thorac Surg 81:243-8. 2006
    This paper describes a muscle-sparing, extrapleural approach to repair aortic coarctation, and evaluates the results with established standards.
  89. ncbi Aortic coarctation in the adult: management of complications and coexisting arterial abnormalities with hypothermic cardiopulmonary bypass and circulatory arrest
    Chris K Rokkas
    Heart Center, Missouri Baptist Medical Center, St Louis, MO, USA
    J Thorac Cardiovasc Surg 124:155-61. 2002
    Adult patients with aortic coarctation may have complications after childhood repair. Other adult patients have coarctation and aneurysms of the aorta and the left subclavian artery...
  90. ncbi A novel aortic coarctation model for studying hypertension in the pig
    Theresa W Fossum
    Michael E DeBakey Institute for Comparative Cardiovascular Sciences and Biomedical Devices, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4474, USA
    J Invest Surg 16:35-44. 2003
    We have developed a reproducible renovascular model of hypertension via a controllable, suprarenal aortic coarctation in the pig...
  91. ncbi Velocity-encoded cine MR imaging in aortic coarctation: functional assessment of hemodynamic events
    Jeffrey J Hom
    Department of Radiology, Thoracic Imaging Section, University of California, San Francisco, Box 0628, L 325, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Radiographics 28:407-16. 2008
    ..cine magnetic resonance (MR) imaging is becoming the modality of choice for the clinical evaluation of aortic coarctation, a congenital narrowing of the thoracic aorta, in which a functional assessment of hemodynamic obstruction ..
  92. ncbi Regional left ventricular myocardial shortening in normotensive patients late after aortic coarctation repair - normal or impaired?
    Mirosław Kowalski
    Department of Congenital Heart Defects, Warsaw, Poland
    Ultrasound Med Biol 35:1947-52. 2009
    Despite successful repair of aortic coarctation (AoC), changes in the left ventricular (LV) regional myocardial function are reported...
  93. ncbi Endarteritis and false aneurysm complicating aortic coarctation
    M Idir
    Services de cardiologie, d Anatomo Pathologie, and de Chirurgie Cardiaque, Hopital Cardiologique, CHU de Bordeaux, Pessac, France
    Ann Thorac Surg 70:966-8; discussion 968-9. 2000
    We report a tricky case of endocarditis because of the localization, aortic coarctation, and the pathogenic bacteria Actinobacillus actinomycetemcomitans...
  94. ncbi Delivery and assessment of endovascular stents to repair aortic coarctation using MR and X-ray imaging
    Maythem Saeed
    Department of Radiology, University of California San Francisco, California 94143 0628, USA
    J Magn Reson Imaging 24:371-8. 2006
    To investigate the utility of MR and X-ray imaging for characterizing aortic coarctation and flow, and guiding the endovascular catheter to place a stent to repair the coarctation.
  95. ncbi Surgical treatment of atypical aortic coarctation associated with occlusion of all arch vessels in Takayasu's disease
    Yuji Sugawara
    First Department of Surgery, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Eur J Cardiothorac Surg 22:836-8. 2002
    We report a patient with Takayasu's disease surgically treated who had presented severe manifestation due to aortic coarctation associated with occlusion of all arch branches...
  96. ncbi [Balloon angioplasty for native aortic coarctation in children younger than 12 months: immediate and medium-term results]
    José Rafael Parra-Bravo
    Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Servicio de Cardiología y Hemodinámica Pediátrica, Mexico
    Arch Cardiol Mex 77:217-25. 2007
    The use of the balloon angioplasty (BA) in the treatment of patients with native aortic coarctation during childhood, particularly during the first 12 months of age, is controversial...
  97. ncbi Alteration of p66shc is associated with endothelial dysfunction in the abdominal aortic coarctation of rats
    Sang Ki Lee
    Infection Signaling Network Research Center, Research Institutes of Biomedical Sciences, Department of Physiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung Gu, Daejeon, Republic of Korea
    FEBS Lett 582:2561-6. 2008
    ..investigated the endothelium-dependent relaxation, protein expression and superoxide production in abdominal aortic coarctation rats...
  98. ncbi One-stage repair of aortic coarctation and ascending aortic aneurysm by extra-anatomic graft
    Guido Gelpi
    Cardiovascular Division, L Sacco Hospital, Milan, Italy
    J Cardiovasc Med (Hagerstown) 10:554-6. 2009
    ..In our opinion, ascending-to-descending extra-anatomic graft is a good solution to treat these complicated cases...
  99. pmc Two stage hybrid approach for complex aortic coarctation repair
    Efstratios Koletsis
    Department of Cardiothoracic Surgery, School of Medicine, University of Patras, Patras, Greece
    J Cardiothorac Surg 4:10. 2009
    Management of an adult patient with aortic coarctation and an associated cardiac pathology poses a great surgical challenge since there are no standard guidelines for the therapy of such complex pathology...
  100. ncbi Balloon angioplasty for native aortic coarctation in different anatomic variants
    I El Sayed Massoud
    Department of Pediatric Cardiology, National Heart Institute, Imbaba, Giza, Egypt
    Pediatr Cardiol 29:521-9. 2008
    ..of left ventricular dimension and function revealed significant improvement after balloon angioplasty of aortic coarctation in patients with the echocardiographic picture of hypertensive cardiomyopathy...
  101. ncbi Three-dimensional volume rendering with multislice computed tomography in the evaluation of Aortic coarctation
    Filippo Cademartiri
    Department of Radiology, Erasmus Medical Center, Dr Molenwaterplein, 40 3015 GD Rotterdam, The Netherlands
    Ital Heart J 4:286-7. 2003

Research Grants23

  1. Proactive Modulation of Strain for Ventricular Recovery
    THERESA FOSSUM; Fiscal Year: 2007
    ..The animal studies will be conducted at the Texas A&M College of Veterinary Medicine by the PI and colleagues who have performed similar animal tests of early stage, assist devices. [unreadable] [unreadable]..
  2. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2005
    ..Using an externally controllable suprarenal aortic coarctation model, we will delineate between purely mechanical effects and those due to engaging the renin-angiotensin ..
  3. Structure & function of cardiac contractile proteins
    Jeffrey Robbins; Fiscal Year: 2004
    ..of the rabbit heart to tolerate gradual increase in afterload, by inducing pressure-overload via trans-aortic coarctation soon after birth and allowing the animals to "grow into" the band during the adolescent and early adult ..
  4. Ribosome Biogenesis: A Molecular Checkpoint for Cardiac Hypertrophy
    Lawrence Rothblum; Fiscal Year: 2009
    ..We found that in several models, including aortic coarctation, the amount of the rDNA transcription factor UBF increased in the cardiomyocytes...
  5. Quantifying altered hemodynamics in response to stenting for aortic coarctation
    JOHN LADISA; Fiscal Year: 2009
    ..Stent implantation continues to emerge as a potential means of treating aortic coarctation, one of the most common forms of congenital heart disease...
  6. MYOCARDIAL INTEGRINS AND VENTRICULAR REMODELING
    JOSEPH JANICKI; Fiscal Year: 2002
    ..Accordingly, this proposal will use a fistula model of chronic ventricular volume overload and an aortic coarctation model of pressure overload to examine cardiac function in the intact animal and at the cellular and ..
  7. IGF::OT::IGF SBIR Topic 079 Phase I- Bioabsorbable Stents for Pediatric Pulmonary
    Maria Palasis; Fiscal Year: 2013
    ..performance of the proposed biodegradablestents in the intended use for pulmonary artery stenosis and aortic coarctation, taking into account mechanicalstrength required for the application;geometry of the access vessels and ..
  8. MOLECULAR AND CELLULAR BIOLOGY OF CARDIAC INTERSTITIUM
    Allen Samarel; Fiscal Year: 1993
    ..and during the development of thyroxine-induced LV hypertrophy, and LV hypertrophy following abdominal aortic coarctation. Specific monoclonal antibody probes will also be developed for use in studies of procollagen polypeptide ..
  9. HEART DEVELOPMENT AND GENETICS
    Mark Fishman; Fiscal Year: 2002
    ..These genes will be of importance as candidate genes for congenital vascular disorders such as aortic coarctation. It will also be of importance to examine these developmental pathways in the context of adult vessel injury,..
  10. Influence of blood pressure on PAD distribution
    Sean Newcomer; Fiscal Year: 2007
    ..To address these aims, a model of aortic coarctation will be utilized to induce a blood pressure gradient similar but opposite to that of an upright human...
  11. Multidisciplinary Study of Right Ventricular Dysplasia
    Jeffrey Towbin; Fiscal Year: 2005
    ..This integrated research grant proposal offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and of localizing the gene(s) responsible for this disorder. ..
  12. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..Consequently, it will identify another component (Ac-SDKP) as part of the multiple mediators participating in the cardioprotective effects of ACEi in hypertension. ..
  13. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..
  14. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  15. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2004
    ..Aside from illuminating one pathway toward the clinical endpoint of PDA, it will provide the starting place for identifying genes critical to ductal development that are activated by Char syndrome-related genes. ..
  16. Disease pathogenesis of Noonan syndrome and related disorders
    Bruce Gelb; Fiscal Year: 2008
    ..Next, a candidate gene approach will be used to identify additional NS gene(s). This will be coupled with the use of human multiplex NS kindreds without PTPN11 mutations. ..
  17. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Cytoskeletal Basis of Ventricular Arrhythmias
    Matteo Vatta; Fiscal Year: 2005
    ..Identifying cytoskeletal mecahnisms involved in malignant arrhythmias, could lead to the design of novel drugs and the employment of therapeutic means, resulting in a better patients management. ..
  19. Genetics of Congenital Left-sided Heart Defects
    Kim McBride; Fiscal Year: 2007
    ..The proposed studies will launch the applicant on an independent research career, providing a base on which to advance genetic analyses of CCVM with the aim to reduce their occurrence and provide new treatment opportunities. ..
  20. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..abstract_text> ..
  21. Mutant ZASP in Cytoskeletal Remodeling and Arrhythmia
    Matteo Vatta; Fiscal Year: 2006
    ..In addition, little is known about the role of Cypher/ZASP mutations in skeletal muscle, and we have suggested that Cypher/ZASP could be a candidate for orphan forms of muscular dystrophies. ..
  22. Extracellular Mechanisms For Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2008
    ..abstract_text> ..
  23. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..