cardiovascular diseases

Summary

Top Publications

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
  2. ncbi Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
  3. ncbi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
  4. ncbi Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
  5. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
  6. ncbi Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
    Sarah Lewington
    Lancet 360:1903-13. 2002
  7. ncbi General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
  8. ncbi The metabolic syndrome--a new worldwide definition
    K George M M Alberti
    Department of Endocrinology and Metabolism, St Marys Hospital, London W2 1NY, UK
    Lancet 366:1059-62. 2005
  9. ncbi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
  10. ncbi Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    Thomas A Pearson
    Circulation 107:499-511. 2003

Detail Information

Publications259 found, 100 shown here

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
    ..Empathy builds trust and is a potent motivator. Finally, in presenting these guidelines, the committee recognizes that the responsible physician's judgment remains paramount...
  2. ncbi Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    Michael J Pencina
    Department of Mathematics and Statistics, Framingham Heart Study, Boston University, Boston, MA 02215, USA
    Stat Med 27:157-72; discussion 207-12. 2008
    ..We illustrate the use of these measures with an example from the Framingham Heart Study. We propose that scientists consider these types of measures in addition to the AUC when assessing the performance of newer biomarkers...
  3. ncbi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
    ..Statins reduce the incidence of cardiovascular events in patients at high cardiovascular risk. However, a benefit of statins in such patients who are undergoing hemodialysis has not been proved...
  4. ncbi Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
    ..Positive experiences, trust in the clinician, and empathy improve patient motivation and satisfaction. This report serves as a guide, and the committee continues to recognize that the responsible physician's judgment remains paramount...
  5. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
    ..End-stage renal disease substantially increases the risks of death, cardiovascular disease, and use of specialized health care, but the effects of less severe kidney dysfunction on these outcomes are less well defined...
  6. ncbi Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
    Sarah Lewington
    Lancet 360:1903-13. 2002
    ..The age-specific relevance of blood pressure to cause-specific mortality is best assessed by collaborative meta-analysis of individual participant data from the separate prospective studies...
  7. ncbi General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
    ..The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents...
  8. ncbi The metabolic syndrome--a new worldwide definition
    K George M M Alberti
    Department of Endocrinology and Metabolism, St Marys Hospital, London W2 1NY, UK
    Lancet 366:1059-62. 2005
  9. ncbi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  10. ncbi Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    Thomas A Pearson
    Circulation 107:499-511. 2003
  11. ncbi Abdominal obesity and metabolic syndrome
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, 2725 Chemin Sainte Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V 4G5, Canada
    Nature 444:881-7. 2006
    ..Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale...
  12. ncbi Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project
    R M Conroy
    Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Eur Heart J 24:987-1003. 2003
    ..The SCORE project was initiated to develop a risk scoring system for use in the clinical management of cardiovascular risk in European clinical practice...
  13. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
    ..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality...
  14. ncbi The metabolic syndrome
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Lancet 365:1415-28. 2005
    ..The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction...
  15. ncbi Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    Scott M Grundy
    Circulation 109:433-8. 2004
  16. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  17. ncbi Major causes of death among men and women in China
    Jiang He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    N Engl J Med 353:1124-34. 2005
    ..We studied the major causes of death and modifiable risk factors in a nationally representative cohort of 169,871 men and women 40 years of age and older in China...
  18. ncbi National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification
    Andrew S Levey
    Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Ann Intern Med 139:137-47. 2003
    ..Because of the high prevalence of early stages of chronic kidney disease in the general population (approximately 11% of adults), this information is particularly important for general internists and specialists...
  19. ncbi ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    Zeljko Reiner
    University Hospital Center Zagreb, School of Medicine, University of Zagreb, Salata 2, 10 000 Zagreb, Croatia
    Eur Heart J 32:1769-818. 2011
    ..g. general practitioners (GPs) and cardiologists] interested in CVD prevention, but also specialists from lipid clinics or metabolic units who are dealing with dyslipidaemias that are more difficult to classify and treat...
  20. ncbi Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis
    Charalambos Vlachopoulos
    Peripheral Vessels Unit, 1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 55:1318-27. 2010
    ..The purpose of this study was to calculate robust quantitative estimates of the predictive value of aortic pulse wave velocity (PWV) for future cardiovascular (CV) events and all-cause mortality by meta-analyses of longitudinal studies...
  21. ncbi Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2746-53. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  22. pmc Vitamin D deficiency and risk of cardiovascular disease
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Circulation 117:503-11. 2008
    ..A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking...
  23. ncbi Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
    Jonathan M Hill
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1622, USA
    N Engl J Med 348:593-600. 2003
    ....
  24. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  25. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  26. ncbi Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...
  27. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
  28. ncbi Effect of a multifactorial intervention on mortality in type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 358:580-91. 2008
    ..We evaluated whether this approach would have an effect on the rates of death from any cause and from cardiovascular causes...
  29. ncbi Sitting time and mortality from all causes, cardiovascular disease, and cancer
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 41:998-1005. 2009
    ..We prospectively examined sitting time and mortality in a representative sample of 17,013 Canadians 18-90 yr of age...
  30. ncbi Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    Christopher P Cannon
    Thrombolysis in Myocardial Infarction TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 350:1495-504. 2004
    ..Lipid-lowering therapy with statins reduces the risk of cardiovascular events, but the optimal level of low-density lipoprotein (LDL) cholesterol is unclear...
  31. pmc C-reactive protein: a critical update
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Clin Invest 111:1805-12. 2003
  32. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  33. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  34. ncbi Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
    Naveed Sattar
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 375:735-42. 2010
    ..We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes...
  35. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  36. ncbi Effects of bariatric surgery on mortality in Swedish obese subjects
    Lars Sjöström
    Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    N Engl J Med 357:741-52. 2007
    ..In fact, many observational studies suggest that weight reduction is associated with increased mortality...
  37. ncbi Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 49:403-14. 2007
    ..The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies...
  38. ncbi Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a meta-analysis
    Anders Grøntved
    Institute of Sport Science and Clinical Biomechanics, Department of Exercise Epidemiology, Center of Research in Childhood Health, University of Southern Denmark, Odense
    JAMA 305:2448-55. 2011
    ..However, a systematic and quantitative assessment of published studies is not available...
  39. pmc The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
    Colin Baigent
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    Lancet 377:2181-92. 2011
    ..The SHARP trial aimed to assess the efficacy and safety of the combination of simvastatin plus ezetimibe in such patients...
  40. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
    ..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
  41. pmc Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
    Francesca Dominici
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 295:1127-34. 2006
    ..5 microm in aerodynamic diameter [PM2.5]) is limited. Results from the new national monitoring network for PM2.5 make possible systematic research on health risks at national and regional scales...
  42. ncbi Exercise capacity and mortality among men referred for exercise testing
    Jonathan Myers
    Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
    N Engl J Med 346:793-801. 2002
    ..There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables...
  43. ncbi Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical
    Paul Poirier
    Circulation 113:898-918. 2006
    ..It is associated with numerous comorbidities such as cardiovascular diseases (CVD), type 2 diabetes, hypertension, certain cancers, and sleep apnea/sleep-disordered breathing...
  44. ncbi Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Circulation 110:227-39. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  45. ncbi Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, Scotland, United Kingdom
    JAMA 305:2556-64. 2011
    ..A recent meta-analysis demonstrated that statin therapy is associated with excess risk of developing diabetes mellitus...
  46. ncbi Mechanisms linking obesity with cardiovascular disease
    Luc F Van Gaal
    University of Antwerp, Faculty of Medicine, Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Nature 444:875-80. 2006
    ..We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health...
  47. pmc Projected effect of dietary salt reductions on future cardiovascular disease
    Kirsten Bibbins-Domingo
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    N Engl J Med 362:590-9. 2010
    ..The U.S. diet is high in salt, with the majority coming from processed foods. Reducing dietary salt is a potentially important target for the improvement of public health...
  48. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  49. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  50. pmc Maternal and child undernutrition: consequences for adult health and human capital
    Cesar G Victora
    Universidade Federal de Pelotas, Pelotas, Brazil
    Lancet 371:340-57. 2008
    ..Its prevention will probably bring about important health, educational, and economic benefits. Chronic diseases are especially common in undernourished children who experience rapid weight gain after infancy...
  51. pmc Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
    Paul E Ronksley
    Department of Community Health Sciences, Faculty of Medicine, Calgary Institute for Population and Public Health, University of Calgary, Alberta, Canada
    BMJ 342:d671. 2011
    ..To conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes...
  52. ncbi Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
    Am J Clin Nutr 92:1189-96. 2010
    ..The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes...
  53. pmc Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
    Elizabeth Selvin
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    N Engl J Med 362:800-11. 2010
    ..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
  54. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    ..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
  55. ncbi Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
    ..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
  56. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
    ..Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention...
  57. ncbi Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
    ..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
  58. ncbi The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
    Guangwei Li
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    Lancet 371:1783-9. 2008
    ..We aimed to assess whether intensive lifestyle interventions have a long-term effect on the risk of diabetes, diabetes-related macrovascular and microvascular complications, and mortality...
  59. ncbi Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?
    Stephan Fichtlscherer
    Division of Cardiology, Department of Medicine III, Goethe University, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 31:2383-90. 2011
    ..circulating miRs opens up intriguing possibilities to use the circulating miR patterns as biomarker for cardiovascular diseases. Cardiac injury as it occurs after acute myocardial infarction increases the circulating levels of ..
  60. pmc Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis
    F G R Fowkes
    JAMA 300:197-208. 2008
    ..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
  61. ncbi Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  62. ncbi Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
    Ronald P Mensink
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 77:1146-55. 2003
    ..Fats, however, also affect HDL cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is LDL cholesterol...
  63. ncbi Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss
    Carl J Lavie
    Cardiac Rehabilitation, Exercise Laboratories, Ochsner Medical Center, New Orleans, Louisiana 70121 2483, USA
    J Am Coll Cardiol 53:1925-32. 2009
    ....
  64. ncbi Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    D W Dunstan
    Baker IDI Heart and Diabetes Institute, 250 Kooyong Rd, Caulfield, Victoria, Australia 3162
    Circulation 121:384-91. 2010
    ..We examined the associations of prolonged television viewing time with all-cause, cardiovascular disease (CVD), cancer, and non-CVD/noncancer mortality in Australian adults...
  65. ncbi Effects of torcetrapib in patients at high risk for coronary events
    Philip J Barter
    Heart Research Institute, Camperdown, Sydney, NSW, Australia
    N Engl J Med 357:2109-22. 2007
    ..We investigated whether torcetrapib, a potent CETP inhibitor, might reduce major cardiovascular events. The trial was terminated prematurely because of an increased risk of death and cardiac events in patients receiving torcetrapib...
  66. pmc 25-hydroxyvitamin D levels and the risk of mortality in the general population
    Michal L Melamed
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 615, Bronx, NY 10461, USA
    Arch Intern Med 168:1629-37. 2008
    ..However, whether low serum 25(OH)D levels are associated with mortality in the general population is unknown...
  67. ncbi Epidemiology of obstructive sleep apnea: a population health perspective
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Am J Respir Crit Care Med 165:1217-39. 2002
    ..Primary care providers will be central to clinical approaches for addressing the burden and the development of cost-effective case-finding strategies and feasible treatment for mild obstructive sleep apnea warrants high priority...
  68. ncbi Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis
    Satoru Kodama
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 3 2 7 Miya machi, Mito, Ibaraki 310 0015, Japan
    JAMA 301:2024-35. 2009
    ..Epidemiological studies have indicated an inverse association between cardiorespiratory fitness (CRF) and coronary heart disease (CHD) or all-cause mortality in healthy participants...
  69. ncbi Elevated C-reactive protein levels in overweight and obese adults
    M Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    JAMA 282:2131-5. 1999
    ..Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat...
  70. pmc Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies
    Brendan J Keating
    The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, USA
    PLoS ONE 3:e3583. 2008
    ..These datasets will also facilitate more robust secondary analyses, such as explorations with alternative genetic models, epistasis and gene-environment interactions...
  71. pmc Childhood obesity, other cardiovascular risk factors, and premature death
    Paul W Franks
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    N Engl J Med 362:485-93. 2010
    ..The effect of childhood risk factors for cardiovascular disease on adult mortality is poorly understood...
  72. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  73. ncbi The pathophysiology of cigarette smoking and cardiovascular disease: an update
    John A Ambrose
    Comprehensive Cardiovascular Center, Saint Vincent Catholic Medical Centers of New York, New York, New York 10011, USA
    J Am Coll Cardiol 43:1731-7. 2004
    ..Recent experimental and clinical data support the hypothesis that cigarette smoke exposure increases oxidative stress as a potential mechanism for initiating cardiovascular dysfunction...
  74. ncbi Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
    ..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
  75. ncbi Adipose tissue, inflammation, and cardiovascular disease
    Anders H Berg
    Department of Cell Biology, Bronx, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 96:939-49. 2005
    ..The targeted suppression of various proinflammatory cascades in adipocytes specifically represents an exciting new therapeutic opportunity for the cardiovascular disease area...
  76. ncbi Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey
    David Martins
    Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
    Arch Intern Med 167:1159-65. 2007
    ..Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D...
  77. pmc Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI, USA
    Sleep 31:1071-8. 2008
    ..SDB is linked to incident cardiovascular disease, stroke, and other morbidity. However, the risk of mortality with untreated SDB, determined by polysomnography screening, in the general population has not been established...
  78. ncbi Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 107:363-9. 2003
  79. ncbi Global burden of blood-pressure-related disease, 2001
    Carlene M M Lawes
    Clinical Trials Research Unit, University of Auckland, Auckland, New Zealand
    Lancet 371:1513-8. 2008
    ..Few studies have assessed the extent and distribution of the blood-pressure burden worldwide. The aim of this study was to quantify the global burden of disease related to high blood pressure...
  80. pmc Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    Frank M Sacks
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 360:859-73. 2009
    ..The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year...
  81. ncbi Cause-specific excess deaths associated with underweight, overweight, and obesity
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 298:2028-37. 2007
    ..The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population...
  82. ncbi Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2855-64. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  83. ncbi Severe hypoglycemia and risks of vascular events and death
    Sophia Zoungas
    George Institute for International Health, University of Sydney, Sydney, Australia
    N Engl J Med 363:1410-8. 2010
    ..We analyzed data from a large study of intensive glucose lowering to explore the relationship between severe hypoglycemia and adverse clinical outcomes...
  84. ncbi HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events
    Philip Barter
    Heart Research Institute, Sydney, Australia
    N Engl J Med 357:1301-10. 2007
    ..High-density lipoprotein (HDL) cholesterol levels are a strong inverse predictor of cardiovascular events. However, it is not clear whether this association is maintained at very low levels of low-density lipoprotein (LDL) cholesterol...
  85. ncbi Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials
    Philippe Autier
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Arch Intern Med 167:1730-7. 2007
    ..We examined the risk of dying from any cause in subjects who participated in randomized trials testing the impact of vitamin D supplementation (ergocalciferol [vitamin D(2)] or cholecalciferol [vitamin D(3)]) on any health condition...
  86. ncbi Prevalence of chronic kidney disease in the United States
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 298:2038-47. 2007
    ..Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during this period is uncertain...
  87. pmc Health benefits of physical activity: the evidence
    Darren E R Warburton
    School of Human Kinetics, University of British Columbia, and the Healthy Heart Program, St Paul s Hospital, Vancouver, BC
    CMAJ 174:801-9. 2006
    ..There appears to be a linear relation between physical activity and health status, such that a further increase in physical activity and fitness will lead to additional improvements in health status...
  88. ncbi Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
    ..We investigated the effect of addition of an angiotensin-receptor blocker to current treatments...
  89. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  90. ncbi Leukocyte telomere length and cardiovascular disease in the cardiovascular health study
    Annette L Fitzpatrick
    Department of Epidemiology, School of Public Health and Community Medicine, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA 98115, USA
    Am J Epidemiol 165:14-21. 2007
    ..22, 95% confidence interval: 1.29, 8.02). These results support the hypotheses that telomere attrition may be related to diseases of aging through mechanisms involving oxidative stress, inflammation, and progression to CVD...
  91. pmc Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2
    Julia Hippisley-Cox
    Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 336:1475-82. 2008
    ....
  92. ncbi Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries
    Kornelia Kotseva
    Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 373:929-40. 2009
    ....
  93. ncbi Economic burden of cardiovascular diseases in the enlarged European Union
    Jose Leal
    Department of Public Health, Health Economics Research Centre, Oxford University, Old Road Campus, Oxford OX3 7LF, UK
    Eur Heart J 27:1610-9. 2006
    ....
  94. pmc Fine particulate air pollution and its components in association with cause-specific emergency admissions
    Antonella Zanobetti
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Environ Health 8:58. 2009
    ..We explored whether the association between cause-specific hospital admissions and PM(2.5) was modified by PM(2.5) chemical composition...
  95. ncbi Systematic review of guidelines on cardiovascular risk assessment: Which recommendations should clinicians follow for a cardiovascular health check?
    Bart S Ferket
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Arch Intern Med 170:27-40. 2010
    ..To appraise guidelines on cardiovascular risk assessment to guide selection of screening interventions for a health check...
  96. pmc Fine particle sources and cardiorespiratory morbidity: an application of chemical mass balance and factor analytical source-apportionment methods
    Jeremy A Sarnat
    Rollins School of Public Health of Emory University, Department of Environmental and Occupational Health, 1518 Clifton Rd, Room 260, Atlanta, GA 30322, USA
    Environ Health Perspect 116:459-66. 2008
    ..We analyzed a time-series of chemically speciated PM measurements in Atlanta, Georgia, and conducted an epidemiologic analysis using data from three distinct source-apportionment methods...
  97. ncbi Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou
    Thomas G Pickering
    Hypertension 45:142-61. 2005
    ..There is increasing evidence that a failure of blood pressure to fall during the night may be associated with increased risk. In obese patients and children, the use of an appropriate cuff size is of paramount importance...
  98. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
    ..Few population studies addressed the prognostic significance of aortic pulse wave velocity (APWV) above and beyond other cardiovascular risk factors...
  99. ncbi Systematic review: glucose control and cardiovascular disease in type 2 diabetes
    Tanika N Kelly
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA
    Ann Intern Med 151:394-403. 2009
    ..Results from clinical trials examining the effect of intensive glucose control on cardiovascular disease have been conflicting...
  100. pmc Hospital admissions and chemical composition of fine particle air pollution
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, 195 Prospect St, New Haven, CT 06511, USA
    Am J Respir Crit Care Med 179:1115-20. 2009
    ..5)) on human health. The hypothesis has been advanced to include the possibility that such differences might be due to variations in the PM(2.5) chemical composition, but evidence supporting this hypothesis is lacking...
  101. pmc Health consequences of obesity
    J J Reilly
    University of Glasgow Division of Developmental Medicine, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, UK
    Arch Dis Child 88:748-52. 2003
    ..The aim of the present review was therefore to provide a critically appraised, evidence based, summary of the consequences of childhood obesity in the short term (for the child) and longer term (in adulthood)...

Research Grants70

  1. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..e., cardiovascular diseases [CVD])...
  2. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..Recent findings show that peroxidases are related to cardiovascular diseases including atherosclerosis...
  3. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..Alteration of bile acid synthesis impairs metabolic homeostasis leading to diabetes, obesity, and cardiovascular diseases. CYP7A1 is the rate-limiting enzyme of the bile acid biosynthetic pathway in the liver...
  4. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..together with the evolution of increasingly efficient gene transfer technology, have placed some cardiovascular diseases within reach of gene-based therapies...
  5. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..g. obesity;diabetes;sexually transmitted diseases;hepatitis B;cardiovascular diseases;and cervical, breast, colorectal, liver, and lung cancer), and 4) incorporation of infrastructure service ..
  6. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    Inflammation is a key component of cardiovascular diseases and related pathophysiological processes, including atherosclerosis, autoimmunity, allograft rejection, the diabetes-metabolic syndrome, hemostasis and thrombosis, and wound ..
  7. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..Every year in the United States nearly 1 million deaths occur among the 7 million people affected with cardiovascular diseases. The dominant underlying factor for this disease includes elevated plasma low density lipoprotein (LDL)-..
  8. PET Imaging of Myocardial Oxidative Stress in T2DM
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..Moreover, oxidative stress secondary to increased ROS is central to pathogenesis various cardiovascular diseases including arteriosclerosis, hypertension, and heart failure...
  9. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..trial-the VITamin D and OmegA-3 TriaL (VITAL), whose endpoints are primary prevention of cancer and cardiovascular diseases-to conduct the first major evaluation of the role of vitamin D and long-chain marine omega-3 ..
  10. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..problems with consequences including increased risk of motor vehicle accidents and the development of cardiovascular diseases with risk for sudden death...
  11. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..These obese patients have significantly elevated morbidity and mortality to many cardiovascular diseases including: hypertension, stroke, coronary artery disease, cardiomyopathies, myocardial infarction, ..
  12. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..protein to central neurons using nanomedicine-based technologies for the improved treatment of neuro-cardiovascular diseases. Angiotensin II (AngII), the primary effectors peptide of the renin-angiotensin system, plays a critical ..
  13. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The most important medical challenges include cardiovascular diseases, stroke, degenerative neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, ..
  14. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..Anemia, cardiovascular diseases, secondary hyperparathyroidism, renal osteodystrophy and other complications are common in CKD...
  15. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..b>Cardiovascular diseases are the leading cause of morbidity and mortality in the United States and the presence of CKD is now ..
  16. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..in our preliminary results) have not been appreciated and might have important implications for the use of KCNQ channel modulators in existing therapies as well as for their potential use in the treatment of cardiovascular diseases.
  17. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..The prevalence of cardiovascular diseases (CVD: Stroke, hypertension, heart failure) in males and females was ~73% at age 60-79...
  18. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Project Narrative Prevalent cardiovascular diseases such as chronic hypertension and ischemic heart disease result in cardiac hypertrophy and the development ..
  19. Molecular Mechanism of Acrolein-Induced Vascular Toxicity: Role of PPAR gamma and
    Zivar Yousefipour; Fiscal Year: 2013
    ..Incidents of cardiovascular diseases (CVD) are higher in African- Americans and may be partially due to lower socioeconomic status of the ..
  20. Regulation of the Endothelial Citrulline-Nitric Oxide Cycle
    Duane C Eichler; Fiscal Year: 2010
    ..implications for developing beneficial therapeutic strategies that simultaneously target metabolic and cardiovascular diseases using the rat diabetic model system...
  21. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..and Ang AT1 receptor of the renin-angiotensin system (RAS) participate in the pathophysiology of various cardiovascular diseases including hypertension and stroke...
  22. Molecular physiology of voltage-gated Ca2+ channels
    Jian Yang; Fiscal Year: 2013
    ..Their mutations and malfunction cause a variety of diseases, including epilepsy, ataxia, cardiovascular diseases, and autism...
  23. ANP Receptor: Molecular approach of signaling mechanisms
    Kailash N Pandey; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Hypertension affects one billion people worldwide, and it is a potent risk factor for cardiovascular diseases. The proposed research should further our understanding of the mechanisms by which cardiac hormones ..
  24. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..mouse models expressing mutant LmnaD300N and LmnaR644C found in patients with progressive degenerative cardiovascular diseases. The p...
  25. Nitrated fatty acids/PPARgamma in the control of renal and vascular functions
    Tianxin Yang; Fiscal Year: 2012
    ..Obesity related insulin resistance and hypertension are a major risk factor for cardiovascular diseases. The PPAR activators thiazolidinediones (TZDs) are highly effective for control of type 2 diabetes and ..
  26. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..Elevated blood concentration of homocysteine (hyperhomocysteinemia;HHcy) is a risk factor for several cardiovascular diseases. Though HHcy impairs microvascular reactivity to pharmacologic vasodilators, nothing is known of the ..
  27. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..If the investigators'hypothesis is correct, this will lead to novel therapeutic approaches to the treatment of cardiovascular diseases.
  28. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..In addition, EPCs have been extensively investigated as a risk biomarker and outcome predictor in cardiovascular diseases. Nothing is known about the number and function of EPCs in patients with brain AVMs...
  29. ClC-3 Chloride Ion Channels in Vascular Smooth Muscle
    Fred Lamb; Fiscal Year: 2009
    ..So while cells must produce ROS to live and grow, overproduction is clearly linked to cardiovascular diseases such as atherosclerosis and hypertension...
  30. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ....
  31. Control of Cardiogenesis by microRNA Editing
    Kazuko Nishikura; Fiscal Year: 2010
    ..obtained in this proposal will be essential for the future development of miRNA-based therapy of various cardiovascular diseases. Public Health Relevance: Our research proposal, based on previously unexplored paradigms, will reveal ..
  32. Prevention of high fat diet-induced vascular injury
    Ming Hui Zou; Fiscal Year: 2013
    ..approaches will yield important insights into how omega-3 polyunsaturated fatty acids protect against cardiovascular diseases. Importantly, completion of the proposed studies will also provide novel insights into whether 26S ..
  33. Mitochondrial Biomarkers of Cardiomyopathy and Cure in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    ..A common feature of chagasic and other cardiovascular diseases is the functional changes in mitochondria as an outcome of changes in expression of genes/proteins ..
  34. CEACAM1: A link between metabolic and cardiovascular diseases
    Sonia M Najjar; Fiscal Year: 2013
    ..Answering these questions will delineate new CEACAM1-dependent mechanisms underlying atherosclerosis along the liver/endothelial cell axis, and pinpoint sites of pharmacologic intervention. ..
  35. Sex Differences in Complement during Myocarditis/DCM
    Delisa Fairweather; Fiscal Year: 2013
    ..Men have a higher incidence and severity of cardiovascular diseases (CVDs) including myocarditis/dilated cardiomyopathy (DCM) and heart failure than women...
  36. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Inflammation, in excess, was believed to be an underlying factor in the pathogenesis of proliferative cardiovascular diseases such as atherosclerosis. Phospholipase A2s (PLA2s) play an important role in inflammation...
  37. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..b>Cardiovascular diseases, including coronary heart disease, stroke, and peripheral arterial disease, are the leading cause of ..
  38. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
    ..long term tobacco use has been implicated in complex major health disorders such as cancer, stroke, cardiovascular diseases, and mental disorders...
  39. Checkpoints of TNF Gene Regulation
    Anne Goldfeld; Fiscal Year: 2013
    ..factor (TNF) has been implicated in multiple disease states, including asthma, allergy, arthritis, cardiovascular diseases, inflammatory bowel disease, diabetes, eczema, lupus, several different forms of cancer, and multiple ..
  40. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    ..Insulin resistance has been implicated in the development of cardiovascular diseases in diabetic patients...
  41. Purinergic signaling in sleep apnea
    Elzbieta Kaczmarek; Fiscal Year: 2012
    ..Beside daytime sleepiness, OSA has been implicated in the pathogenesis of cardiovascular diseases, including systemic and pulmonary hypertension, coronary artery disease, congestive heart failure, stroke,..
  42. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..establish the roles, mechanisms and significance of Plg and Lp(a) in physiologically relevant models of cardiovascular diseases. Public Health Relevance: Cardiovascular diseases are the number one cause of death in the US...
  43. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ..With better understanding of molecular pathways of numerous cardiovascular diseases, the latest research has focused on cellular and molecular mechanism of the disease, more particularly to ..
  44. Inflammation and Injury in Obesity Hypertension in African American Adolescents
    Bonita Falkner; Fiscal Year: 2010
    ..The current childhood obesity epidemic predicts rising rates of hypertension, diabetes, and cardiovascular diseases (CVD) with earlier onset and poorer outcomes especially among minority youth...
  45. DEVELOPMENT AND MAINTENANCE OF LENS TRANSPARENCY
    JOHN IRWIN CLARK; Fiscal Year: 2013
    ..in understanding the endogenous function of sHSP in diseases of aging that include neurodegeneration, cardiovascular diseases, muscular dystrophy, AMD (age related macular dystrophy) and cataract...
  46. NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONS
    David Mendelowitz; Fiscal Year: 2013
    ..options for OSA, and little is currently known about the mechanisms responsible for the increased risk of cardiovascular diseases and mortality...
  47. Risk factor-enhanced microvascular responses to ischemia-reperfusion.
    D Neil Granger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cardiovascular diseases associated with tissue ischemia continue to be a leading cause of death worldwide...
  48. Air pollution and the brain: gender as an important determinant of susceptibility
    Lucio G Costa; Fiscal Year: 2013
    ..applicant): The association between air pollution and morbidity and mortality caused by respiratory and cardiovascular diseases is well established;in addition, initial evidence suggests that air pollution may also negatively affect ..
  49. Regulation of IL-6 mediated inflammation and tissue destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2013
    ..synovial cell activation that characterize joint destruction and extra-articular co-morbidities including cardiovascular diseases. IL-6 is a pleiotropic cytokine that transmits its signal via membrane- bound IL-6 receptor (IL-6R) and ..
  50. Hypertension, Kidney and Pregnancy
    Joey P Granger; Fiscal Year: 2013
    ..Hypertension, as seen in preeclampsia (PE), has long been recognized as a major risk factor for cardiovascular diseases, including coronary artery disease, heart failure and stroke, and for ESRD...
  51. Myocardial Injury Associated with Mitochondria-derived Oxygen Free Radical(s)
    Yeong Renn Chen; Fiscal Year: 2013
    ..in the mediation of myocardial injury, to understand the pathogenesis, and to develop a treatment for cardiovascular diseases. The key hypotheses of the major signal pathway leading to protein S-glutathionylation/sulfonation in ..
  52. HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
    Hugh Rosen; Fiscal Year: 2010
    ..been involved in the pathogenesis of several disease conditions such as acute and chronic inflammation, cardiovascular diseases and aging...
  53. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2012
    ..it may aid future development of specific therapeutic strategies against hypercholesterolemia and related cardiovascular diseases. PUBLIC HEALTH RELEVANCE: Bile acids play an invaluable role in the intestinal absorption of food-derived ..
  54. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..Based on our institutional strengths on cellular therapies on cardiovascular diseases, cartilage and bone repair, Specific Aim 2a: We shall compare the viability of stem cells and their ..
  55. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..our research is to develop highly effective SPECT imaging techniques to screen and diagnose patients with cardiovascular diseases and to guide their therapy...
  56. Molecular Pathogenesis of Chronic Kidney Disease-Dependent Vascular Calcification
    Makoto Miyazaki; Fiscal Year: 2013
    ..In fact, more than half of all deaths in CKD subjects can be attributed to cardiovascular diseases. We hypothesized that a central event in the pathogenesis of CKD-dependent vascular calcification is ..
  57. Integrated Cardio-Renal Risk Prediction Models in Type 1 Diabetes
    Marian J Rewers; Fiscal Year: 2010
    ..as uric acid, vitamin D and bone metabolism markers have been suggested to play a role in both renal and cardiovascular diseases. As a result, it is of critical public health importance to discover and validate new biomarkers for ..
  58. Regulation of an Iron Import Facilitator by Transcriptional Interference
    CAMILLE REYES NERY; Fiscal Year: 2010
    ..where iron deficiency causes anemia, while an excess of iron results in hemochromatosis, both serious cardiovascular diseases. In Saccharomyces cerevisiae, genes encoding iron transporters and iron uptake facilitators are activated ..
  59. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    ..In its efforts to develop new treatments of cardiovascular diseases, the NIH NHLBI has funded development of pulsatile and nonpulsatile mechanical circulatory assist devices ..
  60. Smooth muscle adhesion and plasticity in coronary and outflow tract development
    Joan M Taylor; Fiscal Year: 2013
    ..control of these processes contributes to the progression of several prominent congenital and adult onset cardiovascular diseases. Extensive studies indicate that these SMC functions are regulated by growth factors and extracellular ..
  61. Role of microRNAs in lipid metabolism and cardiovascular disease
    Carlos Fernandez Hernando; Fiscal Year: 2013
    ..by applicant): Aberrant regulation of cholesterol and lipid homeostasis leads to metabolic syndrome and cardiovascular diseases. microRNAs (miRNA) are short non-coding RNAs that control gene expression predominantly through post-..
  62. Regulation of Endothelial Nitric Oxide Synthase mRNA stability
    Jianxin Sun; Fiscal Year: 2013
    ..LDL decrease eNOS levels, which may contribute to the endothelial dysfunction associated with many cardiovascular diseases such as atherosclerosis and heart failure...
  63. Fetal Programming and Human Physical Performance
    Tom Brutsaert; Fiscal Year: 2009
    ..increases risk for certain chronic diseases into adulthood, including diabetes type 2, hypertension, and cardiovascular diseases. For example, individuals born at low BW show a tendency towards insulin resistance and increased ..
  64. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..recorded, a baseline stored blood and urine repository, as well as follow-up events information including cardiovascular diseases, hospitalizations, and death...
  65. Clinical Research and Mentoring in Oral Epidemiology
    Kaumudi Joshipura; Fiscal Year: 2009
    ..focuses on the relationships between oral conditions, inflammatory markers, nutrition and specific cardiovascular diseases. She has expanded this work to include additional cardiovascular endpoints and pregnancy outcomes, and is ..
  66. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..S. and is well recognized as a major risk factor for a broad range of cardiovascular diseases such as stroke, congestive heart failure, renal disease, and congestive heart failure...
  67. ALTERATIONS IN BODY COMPOSITION AND GROWTH AT PUBERTY
    Alan Rogol; Fiscal Year: 1999
    ..and treatment of various disease processes including non insulin-dependent diabetes mellitus (NIDDM), cardiovascular diseases (CVD) and osteopenia, whose antecedents likely occur during childhood and adolescence...
  68. Enhancing the Obesity Prevention Program at Harvard's DACP
    Matthew W Gillman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cardiovascular diseases (CVD) are the leading causes of death and disability in the US. Obesity and its behavioral components, lack of physical activity and poor diet, are major determinants of CVD...
  69. Economic Contextual Influences on Population Diet and Obesity
    Lisa Powell; Fiscal Year: 2010
    ..and obesity have been linked to increased risks for a number of chronic diseases including cancer and cardiovascular diseases. The proposed research will investigate the relationship between food (candy, baked goods, and chips), ..
  70. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2005
    Hypertension remains as a major risk factor for a multitude of cardiovascular diseases, and as such it is responsible for significant morbidity and mortality...