mucormycosis

Summary

Summary: Infection in humans and animals caused by any fungus in the order Mucorales (e.g., Absidia, Mucor, Rhizopus etc.) There are many clinical types associated with infection of the central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an opportunistic infection in patients with a chronic debilitating disease, particularly uncontrolled diabetes, or who are receiving immunosuppressive agents. (From Dorland, 28th ed)

Top Publications

  1. pmc Recent advances in the management of mucormycosis: from bench to bedside
    Brad Spellberg
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, 1124 West Carson St, RB2, Torrance, CA 90502, USA
    Clin Infect Dis 48:1743-51. 2009
  2. ncbi Nosocomial fungal infections: epidemiology, diagnosis, and treatment
    Joshua Perlroth
    Division of Infectious Diseases, Harbor University of California Los Angeles UCLA Medical Center, California 90502, USA
    Med Mycol 45:321-46. 2007
  3. ncbi Epidemiology and clinical manifestations of mucormycosis
    George Petrikkos
    National and Kapodistrian University of Athens, Attikon Hospital, Haidari, Athens, Greece
    Clin Infect Dis 54:S23-34. 2012
  4. pmc The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts
    Sarah P Georgiadou
    Infectious Diseases Unit, Pathophysiology Department, Laikon General Hospital and Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Clin Infect Dis 52:1144-55. 2011
  5. pmc Pathogenesis of mucormycosis
    Ashraf S Ibrahim
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, University of California Los Angeles, 1124 W Carson St, Torrance, CA 90502, USA
    Clin Infect Dis 54:S16-22. 2012
  6. ncbi Invasive mycoses: strategies for effective management
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Med 125:S25-38. 2012
  7. pmc Mucormycosis caused by unusual mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia species
    Marisa Z R Gomes
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Rev 24:411-45. 2011
  8. pmc Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: molecular mycologic perspectives
    Kyung J Kwon-Chung
    Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Clin Infect Dis 54:S8-S15. 2012
  9. ncbi Healthcare-associated mucormycosis
    Blandine Rammaert
    Sorbonne Paris Cité, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, Paris Cedex 15, France
    Clin Infect Dis 54:S44-54. 2012
  10. ncbi Diabetes and mucormycosis: a complex interplay
    B Rammaert
    Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Institut Imagine, AP HP, 149, rue des Sèvres, 75743 Paris Cedex 15, France
    Diabetes Metab 38:193-204. 2012

Research Grants

  1. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
  2. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf S Ibrahim; Fiscal Year: 2013
  3. Amphotericin B Analogs
    Charles Hutchinson; Fiscal Year: 2009
  4. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf Ibrahim; Fiscal Year: 2005
  5. Treatment of Fungal Infections with ATAK Cells
    Ashraf Ibrahim; Fiscal Year: 2004
  6. Novel Antifungal Strategies for Lethal Mucormycosis
    Ashraf Ibrahim; Fiscal Year: 2007
  7. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
  8. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
  9. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
  10. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005

Detail Information

Publications276 found, 100 shown here

  1. pmc Recent advances in the management of mucormycosis: from bench to bedside
    Brad Spellberg
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, 1124 West Carson St, RB2, Torrance, CA 90502, USA
    Clin Infect Dis 48:1743-51. 2009
    Recent therapeutic advances have the potential to improve outcomes of mucormycosis. Lipid formulations of amphotericin B (LFAB) have evolved as the cornerstone of primary therapy for mucormycosis...
  2. ncbi Nosocomial fungal infections: epidemiology, diagnosis, and treatment
    Joshua Perlroth
    Division of Infectious Diseases, Harbor University of California Los Angeles UCLA Medical Center, California 90502, USA
    Med Mycol 45:321-46. 2007
    ..Nevertheless, the mortality of nosocomial fungal infections remains high, and new therapeutic and preventative strategies are needed...
  3. ncbi Epidemiology and clinical manifestations of mucormycosis
    George Petrikkos
    National and Kapodistrian University of Athens, Attikon Hospital, Haidari, Athens, Greece
    Clin Infect Dis 54:S23-34. 2012
    b>Mucormycosis is an emerging angioinvasive infection caused by the ubiquitous filamentous fungi of the Mucorales order of the class of Zygomycetes...
  4. pmc The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts
    Sarah P Georgiadou
    Infectious Diseases Unit, Pathophysiology Department, Laikon General Hospital and Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Clin Infect Dis 52:1144-55. 2011
    ..sign and reversed halo sign are most commonly associated with invasive pulmonary aspergillosis and pulmonary mucormycosis, respectively...
  5. pmc Pathogenesis of mucormycosis
    Ashraf S Ibrahim
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, University of California Los Angeles, 1124 W Carson St, Torrance, CA 90502, USA
    Clin Infect Dis 54:S16-22. 2012
    b>Mucormycosis is a life-threatening infection that occurs in patients who are immunocompromised because of diabetic ketoacidosis, neutropenia, organ transplantation, and/or increased serum levels of available iron...
  6. ncbi Invasive mycoses: strategies for effective management
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Med 125:S25-38. 2012
    ..often depends on a high index of suspicion, taking into account predisposing factors, host cues favoring mucormycosis, and local epidemiology...
  7. pmc Mucormycosis caused by unusual mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia species
    Marisa Z R Gomes
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Rev 24:411-45. 2011
    ..Mucor, and Lichtheimia (formerly Absidia) species are the most common members of the order Mucorales that cause mucormycosis, accounting for 70 to 80% of all cases...
  8. pmc Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: molecular mycologic perspectives
    Kyung J Kwon-Chung
    Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Clin Infect Dis 54:S8-S15. 2012
    ..was originally described as a convenient and inclusive name for 2 clinicopathologically different diseases, mucormycosis caused by members of Mucorales and entomophthoramycosis caused by species in the order Entomophthorales of ..
  9. ncbi Healthcare-associated mucormycosis
    Blandine Rammaert
    Sorbonne Paris Cité, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, Paris Cedex 15, France
    Clin Infect Dis 54:S44-54. 2012
    b>Mucormycosis is a severe emerging invasive fungal infection that occurs as a consequence of environmental exposure...
  10. ncbi Diabetes and mucormycosis: a complex interplay
    B Rammaert
    Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Institut Imagine, AP HP, 149, rue des Sèvres, 75743 Paris Cedex 15, France
    Diabetes Metab 38:193-204. 2012
    b>Mucormycosis is a life-threatening invasive fungal infection that arises particularly in diabetic patients with or without other underlying conditions such as haematological malignancies or the need for solid-organ transplantation...
  11. ncbi Pulmonary mucormycosis
    Georgios Hamilos
    Department of Internal Medicine, School of Medicine, University of Crete, Heraklion, Greece
    Semin Respir Crit Care Med 32:693-702. 2011
    b>Mucormycosis (formerly zygomycosis) is a life-threatening opportunistic mycosis that infects a broad range of hosts with qualitative or quantitative defects in innate immunity, including patients with severe neutropenia, recipients of ..
  12. pmc The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial
    Brad Spellberg
    Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor University of California Los Angeles UCLA Medical Center, Torrance, CA, USA
    J Antimicrob Chemother 67:715-22. 2012
    Host iron availability is fundamental to mucormycosis pathogenesis. The combination of liposomal amphotericin B (LAmB) and deferasirox iron chelation therapy synergistically improved survival in diabetic mice with mucormycosis...
  13. ncbi Necrotizing cutaneous mucormycosis after a tornado in Joplin, Missouri, in 2011
    Robyn Neblett Fanfair
    Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 367:2214-25. 2012
    b>Mucormycosis is a fungal infection caused by environmentally acquired molds. We investigated a cluster of cases of cutaneous mucormycosis among persons injured during the May 22, 2011, tornado in Joplin, Missouri.
  14. ncbi Primary gastrointestinal mucormycosis in an immunocompetent person
    B N Shiva Prasad
    Department of Medicine, KMC, Manipal, Karnataka, India
    J Postgrad Med 54:211-3. 2008
    In the past decade, mucormycosis has emerged as an important lethal infection in diabetics and other immunocompromised hosts...
  15. pmc Usefulness of molecular biology performed with formaldehyde-fixed paraffin embedded tissue for the diagnosis of combined pulmonary invasive mucormycosis and aspergillosis in an immunocompromised patient
    Veronique Hofman
    Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, 30 Avenue de la Voie Romaine, Nice, France
    Diagn Pathol 5:1. 2010
    ..We report a case of fatal necrotic pneumonia caused by combined pulmonary invasive mucormycosis and aspergillosis in a 66 year-old renal transplant recipient...
  16. ncbi Rhinocerebral mucormycosis: pathways of spread
    Seid Mousa Sadr Hosseini
    Department of Otolaryngology, Vali e Asr Hospital, Teheran University of Medical Sciences, Iran
    Eur Arch Otorhinolaryngol 262:932-8. 2005
    Rhinocerebral mucormycosis is an invasive, opportunistic fungal infection usually seen in immunocompromised patients, and particularly in the setting of diabetes or immune deficiency...
  17. ncbi Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment
    R M Prabhu
    Division of Infectious Diseases Division of Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Microbiol Infect 10:31-47. 2004
    ..Rhizomucor, Absidia, Apophysomyces, Cunninghamella and Saksenaea) cause an angioinvasive infection called mucormycosis. Mucormycosis presents with rhino-orbito-cerebral, pulmonary, disseminated, cutaneous, or gastrointestinal ..
  18. pmc Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006
    Dounia Bitar
    Infectious Diseases Department, Institut de Veille Sanitaire, Saint Maurice, France
    Emerg Infect Dis 15:1395-401. 2009
    ..Incidence also increased in the population of patients with diabetes mellitus. We conclude that observed trends reflect a genuine increase of zygomycosis cases in at-risk populations...
  19. ncbi Prolonged survival of an HIV-infected subject with severe lymphoproliferative disease and rhinocerebral mucormycosis
    Marco Bongiovanni
    J Antimicrob Chemother 60:192-3. 2007
  20. ncbi Treatment of 21 cases of invasive mucormycosis with amphotericin B colloidal dispersion
    R Herbrecht
    Département d Onco Hématologie, Hopital de Hautepierre, Strasbourg, France
    Eur J Clin Microbiol Infect Dis 20:460-6. 2001
    The aim of this study was to review the characteristics and outcome of 21 patients with invasive mucormycosis treated with amphotericin B colloidal dispersion (ABCD) in five phase I and phase II studies...
  21. pmc Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment
    Ashraf S Ibrahim
    Division of Infectious Diseases, Harbor UCLA Medical Center, 1124 West Carson St, RB2, Torrance, CA 90502, USA
    Curr Opin Infect Dis 21:620-5. 2008
    b>Mucormycosis is an increasingly common fungal infection with an unacceptably high mortality despite first-line antifungal therapy. Iron acquisition is a critical step in the causative organisms' pathogenetic mechanism...
  22. ncbi Cytomegalovirus vasculitis and mucormycosis coinfection in late-stage HIV/AIDS
    Jyoti S Samant
    Department of Internal Medicine, Section of Infectious Diseases, Mercer University, School of Medicine, Macon, Georgia 31201, USA
    Am J Med Sci 333:122-4. 2007
    Case reports have previously been published describing various complications of cytomegalovirus (CMV) and mucormycosis in patients with HIV/AIDS...
  23. pmc Presentation and outcome of rhino-orbital-cerebral mucormycosis in patients with diabetes
    A Bhansali
    Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Postgrad Med J 80:670-4. 2004
    To report presentation and outcome of rhino-orbital-cerebral mucormycosis (ROCM) exclusively in patients with diabetes mellitus.
  24. ncbi Acute optic nerve infarction demonstrated by diffusion-weighted imaging in a case of rhinocerebral mucormycosis
    S Mathur
    Department of Radiology, University of Illinois Medical Center at Chicago, Chicago, Ill, USA
    AJNR Am J Neuroradiol 28:489-90. 2007
    SUMMARY: A 60-year-old woman developed right-eye vision loss secondary to rhinocerebral mucormycosis. Routine MR imaging sequences including enhanced MR imaging showed normal optic nerves, but a diffusion-weighted sequence and apparent ..
  25. ncbi Mucormycosis in systemic lupus erythematosus
    Chi Chiu Mok
    Departments of Medicine, Microbiology, Radiology, and Pathology, Tuen Mun Hospital, Hong Kong, China
    Semin Arthritis Rheum 33:115-24. 2003
    To describe a case of mucormycosis in systemic lupus erythematosus (SLE) and to review other patients reported in the English literature.
  26. pmc The iron chelator deferasirox protects mice from mucormycosis through iron starvation
    Ashraf S Ibrahim
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Clin Invest 117:2649-57. 2007
    b>Mucormycosis causes mortality in at least 50% of cases despite current first-line therapies. Clinical and animal data indicate that the presence of elevated available serum iron predisposes the host to mucormycosis...
  27. pmc Apophysomyces elegans: an emerging zygomycete in India
    A Chakrabarti
    Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    J Clin Microbiol 41:783-8. 2003
    ..The study highlights the epidemiology, clinical spectrum, and diagnosis of emerging A. elegans infections...
  28. pmc Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro
    Ashraf S Ibrahim
    Division of Infectious Diseases, St John s Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Bldg RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Infect Immun 73:778-83. 2005
    ..The fact that dead R. oryzae damage human endothelial cells may, in part, explain the lack of efficacy of fungicidal agents during clinical disease...
  29. pmc Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis
    Ashraf S Ibrahim
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Infect Dis 198:1083-90. 2008
    ..We sought to define the role of rhizoxin production by endosymbionts in the pathogenesis of mucormycosis. Endosymbiotic bacteria were identified by polymerase chain reaction in 15 (54%) of 28 clinical isolates of ..
  30. pmc PCR based identification and discrimination of agents of mucormycosis and aspergillosis in paraffin wax embedded tissue
    R Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Keplerstrasse 15, 72074 Tubingen, Germany
    J Clin Pathol 58:1180-4. 2005
    ..Invasive fungal infections are often diagnosed by histopathology without identification of the causative fungi, which show significantly different antifungal susceptibilities...
  31. ncbi Rhinocerebral mucormycosis in a boy with recurrent acute lymphoblastic leukemia: long-term survival with systemic antifungal treatment
    Goetz Wehl
    Department of Pediatrics, University of Innsbruck, Austria
    J Pediatr Hematol Oncol 24:492-4. 2002
    Rhinocerebral mucormycosis is rare in hematologic malignancies and usually leads to death within weeks...
  32. ncbi Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients
    Leonardo Potenza
    Section of Haematology, Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy
    Blood 118:5416-9. 2011
    ..Three developed proven invasive mucormycosis (IM), 17 had infections of known origin but other than IM, and 8 never had fever during the period of ..
  33. ncbi Mucormycosis: its contemporary face and management strategies
    Hsin Yun Sun
    Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    Lancet Infect Dis 11:301-11. 2011
    Several countries have seen rising frequencies of mucormycosis among patients with haematological disorders, malignancies, or diabetes mellitus, and among transplant recipients...
  34. ncbi Cytomegalovirus pneumonia with pulmonary mucormycosis
    Vijaya V Mysorekar
    Department of Pathology, M S Ramaiah Medical College, Bangalore, Karnataka, India
    Indian J Pathol Microbiol 51:294-5. 2008
    ..We describe a case of mixed opportunistic lung infection in the form of cytomegalovirus pneumonia and mucormycosis in a renal transplant recipient...
  35. pmc Rapid susceptibility testing of medically important zygomycetes by XTT assay
    Charalampos Antachopoulos
    Pediatric Oncology Branch, National Cancer Institute, CRC, Rm 1 5750, MSC 1100, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Microbiol 44:553-60. 2006
    ..These results support the use of the XTT method for rapid MIC determination for Zygomycetes...
  36. pmc Mucormycosis, pseudallescheriasis, and other uncommon mold infections
    Clifford Quan
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles UCLA Medical Center, Torrance, California 90502, USA
    Proc Am Thorac Soc 7:210-5. 2010
    ..In this review, we summarize current knowledge about non-Aspergillus mold infections of the chest, with a focus on risk factors, clinical features, diagnosis, and treatment...
  37. ncbi Mucormycosis-associated fungal infections in patients with haematologic malignancies
    I O Kara
    Department of Medical Oncology, Faculty of Medicine, Cukurova University, Turkey
    Int J Clin Pract 63:134-9. 2009
    Among patients with haematologic disorders, mucormycosis most commonly occurs in those with acute leukaemia or lymphoma who have developed neutropenia due to malignancy or to chemotherapy, and in transplanted patients receiving ..
  38. ncbi Preliminary investigation into the prevalence of mucormycosis in the platypus (Ornithorhynchus anatinus) in three catchments in north-west Tasmania
    J W Macgregor
    Conservation Medicine Program, School of Veterinary and Biomedical Sciences, Murdoch University, Western Australia, Australia
    Aust Vet J 88:190-6. 2010
    To investigate the distribution and prevalence of mucormycosis in platypus (Ornithorhynchus anatinus) from the Inglis, Emu and Black-Detention catchment areas in north-west Tasmania.
  39. pmc The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice
    Mingfu Liu
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Clin Invest 120:1914-24. 2010
    b>Mucormycosis is a fungal infection of the sinuses, brain, or lungs that causes a mortality rate of at least 50% despite first-line therapy...
  40. ncbi Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infection
    Russell E Lewis
    Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, TX, USA
    Virulence 2:348-55. 2011
    b>Mucormycosis is an uncommon fungal infection that has been increasingly reported in severely immunocompromised patients receiving Aspergillus-active antifungals...
  41. ncbi Rhinocerebral mucormycosis in a child with acute lymphoblastic leukemia: a case report
    Gheorghe Popa
    Department of Pediatric Oncology, Pediatric Clinic No 2, University of Medicine and Pharmacy, Iuliu Hatieganu Cluj Napoca, Romania
    J Pediatr Hematol Oncol 30:163-5. 2008
    b>Mucormycosis is a life-threatening fungal infection in patients with predisposing conditions.
  42. pmc Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis
    Caitlin Reed
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor, University of California at Los Angeles Medical Center, Torrance, CA, USA
    Clin Infect Dis 47:364-71. 2008
    It has been axiomatic that echinocandins (e.g., caspofungin) are ineffective against mucormycosis. However, on the basis of preclinical data, we recently began treating rhino-orbital-cerebral mucormycosis (ROCM) with combination polyene-..
  43. ncbi Mandibular mucormycosis in immunocompromised patients: report of 2 cases and review of the literature
    Mutan Hamdi Aras
    Department of Oral and Maxillofacial Surgery, Gaziantep University, Gaziantep, Turkey
    J Oral Maxillofac Surg 70:1362-8. 2012
    b>Mucormycosis, also known as zygomycosis, is an opportunistic fungal infection caused by a series of fungi in the Mucorales family in people with immune disorders...
  44. pmc Efficacy of caspofungin in neutropenic and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosis
    Russell E Lewis
    Division of Clinical and Experimental Pharmacology, University of Houston College of Pharmacy, Houston, Texas, USA
    Antimicrob Agents Chemother 55:3584-7. 2011
    ..CFG administered at 16 mg/kg/day was not significantly better than a saline control for treatment of invasive pulmonary mucormycosis (IPM) in either neutropenic or corticosteroid-immunosuppressed animals.
  45. pmc Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009
    Sarah P Hammond
    Division of Infectious Diseases, Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 55:5018-21. 2011
    Mortality due to mucormycosis is high. We assessed clinical characteristics and mortality among stem cell transplant and hematologic malignancy patients diagnosed with mucormycosis from 2001 to 2009...
  46. ncbi Apophysomyces elegans - renal mucormycosis in a healthy host: a case report from south India
    A J Thomas
    Department of Urology, Christian Medical College, Vellore 632 004, Tamil Nadu, India
    Indian J Med Microbiol 26:269-71. 2008
    ..Ureterorenoscopy was performed, fungal elements removed and pathological confirmation obtained. The patient subsequently underwent nephrectomy after treatment with amphotericin B. He made an uneventful recovery...
  47. ncbi Gangrenous cutaneous mucormycosis caused by Rhizopus oryzae: a case report and review of primary cutaneous mucormycosis in China over Past 20 years
    Houmin Li
    Department of Dermatology, Peking University, People s Hospital, Beijing, 100044, People s Republic of China
    Mycopathologia 176:123-8. 2013
    Cutaneous mucormycosis is a rare opportunistic infection caused by zygomycetes that can be rapidly fatal if unrecognized...
  48. pmc Update on mucormycosis pathogenesis
    Ashraf S Ibrahim
    aDivision of Infectious Diseases, Harbor University of California Los Angeles Medical Center bSt John s Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance cDavid Geffen School of Medicine at UCLA, Los Angeles, California dDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Curr Opin Infect Dis 26:508-15. 2013
    b>Mucormycosis is an increasingly common fungal infection with unacceptably high mortality...
  49. ncbi How does antifungal pharmacology differ for mucormycosis versus aspergillosis?
    Russell E Lewis
    Department of College of Pharmacy, The University of Houston, TX 77030, USA
    Clin Infect Dis 54:S67-72. 2012
    ..mortality rates remain relatively unchanged for less common, but highly aggressive, mold infections such as mucormycosis. Recent genome sequencing of Rhizopus oryzae revealed evidence of a whole-genome duplication event during the ..
  50. ncbi Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosis
    Kathrin Scheckenbach
    Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Auris Nasus Larynx 37:322-8. 2010
    Five cases of rhinocerebral mucormycosis (RCM) with different courses of illness and outcomes also due to different therapeutical strategies including Posaconazole as a new therapeutic option are described...
  51. ncbi The "Black Turbinate" sign: An early MR imaging finding of nasal mucormycosis
    S Safder
    Department of Radiology, West Virginia University Hospital, Morgantown, USA
    AJNR Am J Neuroradiol 31:771-4. 2010
    Rhinocerebral mucormycosis is a rare angioinvasive fungal infection that has a strong predilection for patients with poorly controlled diabetes and immunosuppression...
  52. ncbi Early clinical and laboratory diagnosis of invasive pulmonary, extrapulmonary, and disseminated mucormycosis (zygomycosis)
    Thomas J Walsh
    Transplantation Oncology Infectious Diseases Program, Weill Cornell University Medical Center, 1300 York Avenue, New York, NY 10065, USA
    Clin Infect Dis 54:S55-60. 2012
    Early diagnosis of invasive mucormycosis is important for timely therapeutic intervention, improved survival, and reduced morbidity...
  53. ncbi Combination therapy for mucormycosis: why, what, and how?
    Brad Spellberg
    Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, University of California at Los Angeles, 1124 West Carson St, Torrance, CA 90502, USA
    Clin Infect Dis 54:S73-8. 2012
    The high mortality rate of mucormycosis with currently available monotherapy, particularly in hematology patients, has stimulated interest in studying novel combinations of antifungal agents to determine whether superior outcomes might be ..
  54. ncbi Fatal primary cutaneous zygomycosis caused by Saksenaea vasiformis: case report and review of literature
    Robin Kaushik
    Department of General Surgery, Government Medical College Hospital, Chandigarh, India
    Surg Infect (Larchmt) 13:125-9. 2012
    ..Primary cutaneous zygomycosis caused by Saksenaea vasiformis is rare. Such infections usually are not suspected, and delay in their diagnosis and treatment results in a poor outcome...
  55. pmc Evidence implicating Thamnostylum lucknowense as an etiological agent of rhino-orbital mucormycosis
    Immaculata Xess
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    J Clin Microbiol 50:1491-4. 2012
    In this report, we present a case of rhino-orbital mucormycosis in a 57-year-old female with poorly controlled diabetes mellitus...
  56. pmc Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3)
    Anna Skiada
    Department of Propaedeutic Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
    Haematologica 98:492-504. 2013
    b>Mucormycosis is an emerging cause of infectious morbidity and mortality in patients with hematologic malignancies. However, there are no recommendations to guide diagnosis and management...
  57. pmc Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis
    Russell E Lewis
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 207:834-41. 2013
    We hypothesized that tacrolimus, an inhibitor of the calcineurin pathway, would enhance the in vivo activity of posaconazole against Rhizopus oryzae, the Mucorales species most commonly associated with mucormycosis.
  58. pmc Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report
    A A Cagatay
    Department of Clinical Bacteriology and Infectious Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    BMC Infect Dis 1:22. 2001
    b>Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia...
  59. ncbi Rhinocerebral mucormycosis in an 11-year-old boy
    M Gessesse
    Department of Paediatrics, Yekatit 12 Hospital, P.O. Box 257, Addis Ababa, Ethiopia
    Ethiop Med J 39:341-8. 2001
    A patient with diabetic ketoacidosis admitted for treatment developed features characteristic of rhinocerebral mucormycosis, confirmed by histopathologic examination, is presented...
  60. ncbi Long-term posaconazole treatment and follow-up of rhino-orbital-cerebral mucormycosis in a diabetic girl
    Luigi Tarani
    Pediatric Department, University La Sapienza, Rome, Italy
    Pediatr Diabetes 10:289-93. 2009
    ..is safe and beneficial in treatment and prevention of relapses of, otherwise fatal, central nervous system mucormycosis. Mucormycosis is a very rare opportunistic mycotic infection of diabetic children...
  61. ncbi Rhinocerebral mucormycosis in an adolescent with type 1 diabetes mellitus: case report
    R Ganesh
    Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai, India
    Ann Trop Paediatr 28:297-300. 2008
    Rhinocerebral mucormycosis is a severe opportunistic infection affecting immunocompromised patients. A 14-year-old boy with rhino-orbito-cerebral mucormycosis and type 1 diabetes is described...
  62. ncbi In vitro interaction of caspofungin and immunosuppressives against agents of mucormycosis
    Manish Thakur
    Department of Medicine, Wayne State University, Detroit, MI, USA
    J Antimicrob Chemother 66:2312-4. 2011
    b>Mucormycosis is a rare but refractory mycosis with high mortality. Few therapeutic options are available and novel strategies are needed...
  63. ncbi The reversed halo sign as the initial radiographic sign of pulmonary zygomycosis
    A Busca
    Department of Hematology, San Giovanni Battista Hospital, Turin, Italy
    Infection 40:77-80. 2012
    ..This case supports earlier observations that RHS may be an early radiological sign of zygomycosis, facilitating an aggressive diagnostic strategy...
  64. ncbi Rhinocerebral mucormycosis in patients without predisposing medical conditions: a review of the literature
    H Elinav
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Clin Microbiol Infect 15:693-7. 2009
    Rhinocerebral mucormycosis is a rare disease, affecting almost exclusively patients with known predisposing conditions such as diabetes mellitus, immunocompromised status, haemochromatosis or major trauma...
  65. ncbi Rhinocerebral mucormycosis in a patient with cirrhosis and chronic renal failure
    Stavroula Georgopoulou
    Henry Dunant Hospital, 107 Mesogeion Ave, 11526, Athens, Greece
    Hepatogastroenterology 50:843-5. 2003
    b>Mucormycosis is an opportunistic fungal infection caused by Mucorales. The disease is uncommon and produces serious and rapidly fatal infection in diabetic or immunocompromised patients...
  66. ncbi Treatment of rhinocerebral mucormycosis by combination of endoscopic sinus debridement and amphotericin B
    I Alobid
    Department of Otorhinolaryngology, Hospital Clinic of Barcelona, Spain
    Am J Rhinol 15:327-31. 2001
    Rhinocerebral mucormycosis (RCM) is an aggressive fungal infection with a high mortality rate. It frequently develops in patients with uncontrolled diabetes mellitus or immunocompromised patients...
  67. ncbi Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathy
    Peterus Thajeb
    Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan, ROC
    Scand J Infect Dis 36:643-8. 2004
    ..B and surgical debridement of paranasal sinuses in 6 pathologically verified cases of rhino-orbito-cerebral mucormycosis (ROCM). All patients had unnoticed type-2 diabetes mellitus without ketoacidosis...
  68. ncbi Peritoneal mucormycosis in a patient on CAPD
    S Nayak
    Perit Dial Int 27:216-7. 2007
  69. ncbi Successful treatment of pulmonary mucormycosis in a renal transplant recipient with limited pulmonary reserve by combined medical and surgical therapy
    Jordan Y Z Li
    Department of Nephrology and Transplantation Services, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Heart Lung Circ 18:226-8. 2009
    b>Mucormycosis is a rare opportunistic fungal infection in renal transplant recipients which is associated with exceedingly high mortality when inadequately treated...
  70. ncbi Necrosis of nasal cartilage due to mucormycosis in a patient with severe congenital neutropenia due to HAX1 deficiency
    A Fahimzad
    Pediatric Infections Research Center, Mofid Children Hospital, Shaheed Beheshti University of Sciences, Tehran, Iran
    J Investig Allergol Clin Immunol 18:469-72. 2008
    ..The clinical course was complicated by necrosis of the nasal cartilage due to mucormycosis. Molecular studies revealed a homozygous germline HAX1 mutation...
  71. pmc Mucormycosis spondylodiscitis after lumbar disc puncture
    Fei Chen
    Department of Spine Surgery, 2nd Xiangya Hospital, Central South University, Changsha, Hunan, China
    Eur Spine J 15:370-6. 2006
    Vertebral osteomyelitis due to mucormycosis is a rare but fulminant and fatal disease. Only one case has been reported in literature, with postmortem diagnosis...
  72. ncbi Rhino-orbito-cerebral mucormycosis, a retrospective study of 7 cases
    Pablo Santos Gorjón
    Servicio de Otorrinolaringología y Patología Cérvico facial, Hospital Universitario de Salamanca, Salamanca, Espana
    Acta Otorrinolaringol Esp 61:48-53. 2010
    b>Mucormycosis is an opportunistic fungal infection caused by fungi of the Mucorales order. It has a low incidence and is a potentially lethal infection which generally affects patients who are immunocompromised due to systemic disease...
  73. pmc How I treat mucormycosis
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 118:1216-24. 2011
    Unlike invasive aspergillosis, the prognosis and outcome of hematologic malignancy patients who develop invasive mucormycosis have not significantly improved over the past decade as a majority of patients who develop the infection still ..
  74. pmc Isolated pulmonary mucormycosis in an apparently normal host: a case report
    A Butala
    Department of Medicine, St Mary s Hospital and Interfaith Medical Center, Brooklyn, NY 11213, USA
    J Natl Med Assoc 87:572-4. 1995
    b>Mucormycosis is a rare fungal disease commonly affecting individuals with diabetes mellitus, hematological malignancy, and immune deficiency. Isolated pulmonary mucormycosis is extremely rare...
  75. ncbi Isolated renal mucormycosis in children
    Li Jianhong
    Department ofPediatric Surgery, Second University Hospital of Medical College, Shantou University, Guangdong Province, China
    J Urol 171:387-8. 2004
  76. ncbi Fatal rhino-orbito-cerebral infection caused by Saksenaea vasiformis in an immunocompetent individual: first case report from India
    V P Baradkar
    Department of Microbiology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India
    Indian J Med Microbiol 26:385-7. 2008
    ..We believe this case to be the first case of rhino-orbito-cerebral infection due to Saksenaea vasiformis and that of second case in an immunocompetent patient in the world...
  77. pmc Risk factors for mortality in patients with mucormycosis
    Brad Spellberg
    Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor University of California Los Angeles UCLA Medical Center, Los Angeles, CA, USA
    Med Mycol 50:611-8. 2012
    Optimal clinical care and clinical investigation of patients with mucormycosis are limited by absence of controlled trials, and absence of well-defined predictors of mortality or clinical response...
  78. ncbi A global analysis of mucormycosis in France: the RetroZygo Study (2005-2007)
    F Lanternier
    Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, 25 rue du Dr Roux, Paris, France
    Clin Infect Dis 54:S35-43. 2012
    b>Mucormycosis is a deadly invasive fungal infection whose characteristics are only partially understood.
  79. ncbi Fatal cellulitis caused by Apophysomyces elegans
    A J Kindo
    Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai 600 116, India
    Indian J Med Microbiol 25:285-7. 2007
    ..Patient developed angioinvasion, severe cellulitis and finally succumbed to the infection three weeks after admission...
  80. pmc Hepatic mucormycosis mimicking hilar cholangiocarcinoma: a case report and literature review
    Ke Wei Li
    Division of Liver Transplantation, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 16:1039-42. 2010
    b>Mucormycosis is a rare but invasive opportunistic fungal infection associated with a high mortality rate, and normally occurs in immunocompromised patients...
  81. ncbi [Non-fatal disseminated mucormycosis in a solid organ transplant]
    C Minet
    Unité de pneumologie, pole de médecine aiguë communautaire, CHU de Grenoble, France
    Rev Mal Respir 26:998-1002. 2009
    b>Mucormycosis is a rare fungal infection occurring most frequently in immunocompromised patients. The pathogens are filamentous fungi, order of Mucorales. Disseminated mucormycosis is a severe, life treating disease...
  82. ncbi Massive lower gastrointestinal bleeding secondary to colonic mucormycosis
    J Anand
    Gastroenterology Unit, Department of Medicine, RIPAS Hospital, Bandar Seri Begawan BA 1710, Brunei Darussalam
    Med J Malaysia 66:266-7. 2011
    ..She later developed massive lower gastrointestinal bleeding secondary to colonic mucormycosis. Her condition deteriorated rapidly and she died of septicemia...
  83. ncbi [Necrotizing fasciitis in an immunocompetent patient caused by Apophysomyces elegans]
    Carmen Elena Ruiz
    Servicio de Cirugia, Hospital Pablo Tobon Uribe, Medellin, Colombia
    Biomedica 24:239-51. 2004
    ..Later this progressed to the right lumbar area, including the gluteus and the corresponding flank. Antimycotic treatment proved ineffective, and the child died 8 weeks after the accident. Other cases due to this fungus are reviewed...
  84. ncbi Gastrointestinal mucormycosis--an uncommon isolated mucormycosis
    M C Sharma
    Department of Pathology, All India Institute of Medical Sciences, New Delhi
    Indian J Gastroenterol 17:131-3. 1998
    Isolated mucormycosis of the gastrointestinal tract is uncommon, with only two case reports from India.
  85. ncbi Sequence of oral manifestations in rhino-maxillary mucormycosis
    Bharati R Doni
    Department of Oral Medicine and Radiology, Seema Dental College and Hospital, Rishikesh, Uttharakhand, India
    Indian J Dent Res 22:331-5. 2011
    b>Mucormycosis, caused by saprophytic fungi of the order Mucorales of the class Zygomycetes, is a rare opportunistic fungal infection, which has a rapidly progressive and fulminant course with fatal outcome...
  86. ncbi Fatal Apophysomyces elegans infection transmitted by deceased donor renal allografts
    B D Alexander
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 10:2161-7. 2010
    Two patients developed renal mucormycosis following transplantation of kidneys from the same donor, a near-drowning victim in a motor vehicle crash...
  87. ncbi A massive intraventricular thrombosis by disseminated mucormycosis in a patient with myelodysplastic syndrome during deferoxamine therapy
    Naoshi Kubota
    First Department of Internal Medicine, Second Department of Pathology, Tokyo Medical University
    Haematologica 88:EIM13. 2003
  88. ncbi Neonatal lingual and gastrointestinal mucormycosis in a case of low anorectal malformation-a rare presentation
    Rahul Gupta
    Department of Pediatric Surgery, King Edward Memorial Hospital, Mumbai, India
    J Pediatr Surg 46:745-8. 2011
    ..Histopathology of the tissue specimen was suggestive of mucormycosis. Postoperatively, he received intravenous amphotericin B (liposomal) and was started on liquid enteral ..
  89. ncbi Palate ulcer due to mucormycosis
    Dionysios E Kyrmizakis
    Department of Otolaryngology, University of Crete, Greece
    J Laryngol Otol 116:146-7. 2002
    b>Mucormycosis is caused by fungi of the order Mucorales and is one of the most rapidly fatal fungal infections known to man. Rhinocerebral mucormycosis is the most common type and its extension to the orbit and brain is quite usual...
  90. ncbi Successful treatment of massive lower gastrointestinal bleeding caused by mixed infection of cytomegalovirus and mucormycosis in a renal transplant recipient
    J H Ju
    Department of Internal Medicine, Kangnam St. Mary's Hospital, Catholic University of Korea, Seoul, Korea
    Am J Nephrol 21:232-6. 2001
    We describe a case of lower gastrointestinal bleeding due to mixed infection of cytomegalovirus (CMV) and mucormycosis in a renal transplant recipient...
  91. ncbi Case report of hepatic mucormycosis after liver transplantation: successful treatment with liposomal amphotericin B followed by posaconazole sequential therapy
    C S Abboud
    Serviço de Controle de Infecção Hospitalar e Seção Médica de Infectologia, Institute Dante Pazzanese de Cardiologia, Sao Paulo, Brazil
    Transplant Proc 44:2501-2. 2012
    b>Mucormycosis is a rare but emerging fungal infection complicating solid organ transplantation (SOT), with a cumulative incidence of around 2% during the first year after SOT...
  92. ncbi Posaconazole for the treatment of mucormycosis
    D A Enoch
    Clinical Microbiology and Public Health Laboratory, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough City Hospital, Bretton Gate, Peterborough PE3 9GW, UK
    Int J Antimicrob Agents 38:465-73. 2011
    ..there is no strong published clinical evidence to support its role as a single agent in the treatment of mucormycosis. Further studies are required to explore its role as a single agent and in combination therapy for the ..
  93. ncbi Disseminated mucormycosis in an acquired immunodeficiency syndrome (AIDS) patient
    Teruhisa Fujii
    Division of Blood Transfusion Services, Hiroshima University Hospital
    Intern Med 42:129-30. 2003
  94. ncbi Isolated renal allograft arterial mucormycosis: an extremely rare complication
    Mukut Minz
    Nephrol Dial Transplant 18:1034-5. 2003
  95. pmc Apophysomyces elegans: epidemiology, amplified fragment length polymorphism typing, and in vitro antifungal susceptibility pattern
    A Chakrabarti
    Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    J Clin Microbiol 48:4580-5. 2010
    ..Posaconazole is the most active drug against the isolates, followed by itraconazole. The MICs of amphotericin B against A. elegans were higher than those of the other drugs...
  96. ncbi Isolated bilateral renal mucormycosis
    S K Singh
    Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Urology 63:979-80. 2004
  97. ncbi Mucormycosis: a rare but serious infection
    Donna M Eichna
    Inova Fairfax Hospital, Virginia, USA
    Clin J Oncol Nurs 12:108-12. 2008
    ..b>Mucormycosis, also known as zygomycosis, is an opportunistic fungal infection that is seen rarely in the clinical setting ..
  98. ncbi [Rhinocerebral mucormycosis: report on eight cases]
    Raquel Artal
    Hospital Clinico Universitario Lozano Blesa, Zaragoza, Espana
    Acta Otorrinolaringol Esp 61:301-5. 2010
    b>Mucormycosis is a serious condition, usually acute and often fatal, It presents in its most aggressive form in debilitated hosts, usually with diabetic ketoacidosis or immunosuppression...
  99. ncbi Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literature
    Jill H Simmons
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Pediatr Diabetes 6:234-8. 2005
    To illustrate that rapid diagnosis and aggressive treatment of rhinocerebral mucormycosis with internal carotid artery occlusion in a pediatric patient can prevent mortality and significant morbidity.
  100. ncbi Combined mucormycosis and candidiasis of the cecum presenting as a right iliac fossa mass in a patient with chronic kidney disease
    Waqas Wahid Baig
    Department of Nephrology, Kasturba Medical College, Manipal 576104, Karnataka, India
    Travel Med Infect Dis 6:145-7. 2008
    ..To our knowledge, only one case of mucormycosis in an adult, presenting as a mass (appendiceal mass), has been reported [Ter Borg F, Kuijper EJ, van der Lelie ..
  101. ncbi External Iliac artery stent mucormycosis in a renal transplant patient
    Christos D Liapis
    Department of Vascular Surgery, Athens University Medical School, Athens, Greece
    Ann Vasc Surg 20:253-7. 2006
    ..Histological examination of the thrombus revealed hyphae characteristic of mucormycosis. A combination of surgical and medical treatment with intravenous liposomal amphotericin B was applied, which ..

Research Grants16

  1. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..4) define the breadth of protection of ATAK cells against three highly lethal mold infections: aspergillosis, mucormycosis, or fusariosis...
  2. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf S Ibrahim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mucormycosis, most commonly caused by Rhizopus oryzae, is a life-threatening infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), neutropenia, corticosteroid use, and/or ..
  3. Amphotericin B Analogs
    Charles Hutchinson; Fiscal Year: 2009
    ..Amphotericin B (AMB) continues to be an important drug for invasive aspergillosis, candidemia, mucormycosis, fusariosis and Cryptococcosis meningitis because of its potency, broad spectrum of activity and the low ..
  4. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf Ibrahim; Fiscal Year: 2005
    applicant): Mucormycosis is a life-threatening infection that occurs in patients who are immunocompromised due to diabetic ketoacidosis, neutropenia, organ transplantation, and/or increased available serum iron...
  5. Treatment of Fungal Infections with ATAK Cells
    Ashraf Ibrahim; Fiscal Year: 2004
    ..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
  6. Novel Antifungal Strategies for Lethal Mucormycosis
    Ashraf Ibrahim; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Mucormycosis is a life-threatening infection that occurs in patients immunocompromised by diabetic ketoacidosis, neutropenia, corticosteroids, or organ transplantation...
  7. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  8. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  9. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005
    ..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
  11. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  12. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  13. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  14. Impact of ileal content on S typhimurium pathogenesis
    Sara Lawhon; Fiscal Year: 2006
    ..The research collaboration between Dr. B[unreadable]umler in the Texas A&M Health Science Center and Dr. Adams in the College of Veterinary Medicine provides a unique opportunity to achieve this career goal. ..
  15. Prevention/diagnosis/fungal infections/transplantation
    Barbara Alexander; Fiscal Year: 2005
    ..This approach will shorten the time from development to clinical implementation in therapeutic trials and guidelines. ..
  16. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..