histoplasmosis

Summary

Summary: Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)

Top Publications

  1. ncbi Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy
    Karen L Wood
    Division of Pulmonary and Critical Care, Department of Medicine, Infectious Disease, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Respir Crit Care Med 167:1279-82. 2003
  2. ncbi Histoplasmosis
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Infect Dis Clin North Am 17:1-19, vii. 2003
  3. ncbi Diagnosis of acute pulmonary histoplasmosis by antigen detection
    S Swartzentruber
    MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana 46241, USA
    Clin Infect Dis 49:1878-82. 2009
  4. pmc Histoplasmosis among hospitalized febrile patients in northern Tanzania
    Sarah M Lofgren
    Division of Infectious Diseases and International Health, Department of Medicine, Box 102359, Duke University Medical Center, Durham, NC 27710, USA
    Trans R Soc Trop Med Hyg 106:504-7. 2012
  5. ncbi Methamphetamine enhances histoplasmosis by immunosuppression of the host
    Luis R Martinez
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:131-41. 2009
  6. pmc Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis
    Elizabeth P Sampaio
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 131:1624-34. 2013
  7. ncbi Histoplasmosis
    Carol A Kauffman
    Division of Infectious Diseases, Veterans Affairs Ann Arbor Healthcare System, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Clin Chest Med 30:217-25, v. 2009
  8. ncbi IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma
    P Zhou
    Lymphokine Regulation Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 155:785-95. 1995
  9. pmc Histoplasmosis: a clinical and laboratory update
    Carol A Kauffman
    Infectious Diseases Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Healthcare System, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Microbiol Rev 20:115-32. 2007
  10. ncbi Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Clin Infect Dis 41:S204-7. 2005

Detail Information

Publications313 found, 100 shown here

  1. ncbi Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy
    Karen L Wood
    Division of Pulmonary and Critical Care, Department of Medicine, Infectious Disease, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Respir Crit Care Med 167:1279-82. 2003
    ..We report on three patients who developed disseminated histoplasmosis on therapy with TNF-alpha inhibitors...
  2. ncbi Histoplasmosis
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Infect Dis Clin North Am 17:1-19, vii. 2003
    The diagnosis of histoplasmosis depends on recognition of the different clinical manifestations of infection, accompanied by knowledge of the accuracy and limitations of tests used for diagnosis of fungal infections...
  3. ncbi Diagnosis of acute pulmonary histoplasmosis by antigen detection
    S Swartzentruber
    MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana 46241, USA
    Clin Infect Dis 49:1878-82. 2009
    Antigen detection, which has proven useful in diagnosis of disseminated histoplasmosis, has not been studied in acute pulmonary histoplasmosis (APH)...
  4. pmc Histoplasmosis among hospitalized febrile patients in northern Tanzania
    Sarah M Lofgren
    Division of Infectious Diseases and International Health, Department of Medicine, Box 102359, Duke University Medical Center, Durham, NC 27710, USA
    Trans R Soc Trop Med Hyg 106:504-7. 2012
    b>Histoplasmosis may be common in East Africa but the diagnosis is rarely confirmed. We report 9 (0.9%) cases of probable histoplasmosis retrospectively identified among 970 febrile inpatients studied in northern Tanzania...
  5. ncbi Methamphetamine enhances histoplasmosis by immunosuppression of the host
    Luis R Martinez
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:131-41. 2009
    ..We showed that methamphetamine abrogates normal macrophage function, resulting in an inability to control histoplasmosis. Methamphetamine decreased phagocytosis and killing of yeast by primary macrophages by alkalization of the ..
  6. pmc Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis
    Elizabeth P Sampaio
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 131:1624-34. 2013
    ..Dominant gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1) have been associated with chronic mucocutaneous candidiasis...
  7. ncbi Histoplasmosis
    Carol A Kauffman
    Division of Infectious Diseases, Veterans Affairs Ann Arbor Healthcare System, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Clin Chest Med 30:217-25, v. 2009
    b>Histoplasmosis is the most common endemic mycosis causing human infection. Large outbreaks have been ascribed to histoplasmosis, but most infections are sporadic...
  8. ncbi IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma
    P Zhou
    Lymphokine Regulation Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 155:785-95. 1995
    ..However, in individuals with immune deficiency, histoplasmosis is a severe and potentially fatal disease...
  9. pmc Histoplasmosis: a clinical and laboratory update
    Carol A Kauffman
    Infectious Diseases Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Healthcare System, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Microbiol Rev 20:115-32. 2007
    ..Pulmonary infection is the primary manifestation of histoplasmosis, varying from mild pneumonitis to severe acute respiratory distress syndrome...
  10. ncbi Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Clin Infect Dis 41:S204-7. 2005
    ..mice, TNF-alpha is necessary for the generation of a protective immune response to both primary and secondary histoplasmosis. Recent reports indicate that, in humans, treatment with inhibitors of TNF-alpha is associated with ..
  11. pmc Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum
    Rachael Hanby Webster
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Proc Natl Acad Sci U S A 105:14573-8. 2008
    ..This regulatory function is strikingly similar to the role of the Aspergillus Velvet A protein family in spore development in response to light, with the notable distinction that the H. capsulatum circuit responds to temperature...
  12. ncbi Systemic histoplasmosis: a 15-year retrospective institutional review of 111 patients
    Maha A Assi
    Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Medicine (Baltimore) 86:162-9. 2007
    To our knowledge, an institutional review of systemic histoplasmosis has not been conducted in the United States since the major outbreaks in Indianapolis in 1978-4982...
  13. ncbi Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America
    L Joseph Wheat
    MiraVista Diagnostics MiraBella Technologies, Indianapolis, IN 46241, USA
    Clin Infect Dis 45:807-25. 2007
    Evidence-based guidelines for the management of patients with histoplasmosis were prepared by an Expert Panel of the Infectious Diseases Society of America...
  14. ncbi Increased incidence of disseminated histoplasmosis following highly active antiretroviral therapy initiation
    Mathieu Nacher
    CISIH, Cayenne General Hospital, French Guiana
    J Acquir Immune Defic Syndr 41:468-70. 2006
    ..initiation of highly active antiretroviral therapy (HAART) had any influence on the incidence of disseminated histoplasmosis, a retrospective cohort study was performed on 1551 patients followed for up to 12 years...
  15. pmc Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice
    R Allendoerfer
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio 45267 0560, USA
    Infect Immun 65:2564-9. 1997
    ..To determine if IFN-gamma is necessary in reexposure histoplasmosis, GKO and WT mice were inoculated with 10(4) yeasts intranasally and given amphotericin B for 3 weeks...
  16. ncbi Chronic infection and reactivation in a pulmonary challenge model of histoplasmosis
    M Durkin
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Infect Dis 183:1822-4. 2001
    Reactivation may be a mechanism for the development of histoplasmosis in AIDS. In this study, histoplasmosis was reactivated by the depletion of CD4 and CD8 lymphocytes in mice...
  17. pmc Interleukin-1 and host control of pulmonary histoplasmosis
    George S Deepe
    Cincinnati Veterans Affairs Medical Center and Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Infect Dis 194:855-64. 2006
    ..Hence, we examined the influence that IL-1beta and IL-1 signaling has on host defenses against pulmonary histoplasmosis. In IL-1 receptor 1 knockout (IL-1R(-/-)) mice challenged intratracheally, fungal recovery on day 7 after ..
  18. pmc Evaluation of two nested PCR assays for detection of Histoplasma capsulatum DNA in human tissue
    Ralf Bialek
    Institute for Tropical Medicine, University Hospital Tubingen, Keplerstrasse 15, 72074 Tubingen, Germany
    J Clin Microbiol 40:1644-7. 2002
    In order to evaluate the diagnostic relevance of two nested PCR assays for diagnosis of histoplasmosis in clinical specimens, 100 paraffin-embedded biopsy specimens were examined...
  19. ncbi American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis
    Pierre Couppie
    Service de Dermatologie, French Guiana, Centre Hospitalier de Cayenne, Centre Hospitalier de Cayenne, Cayenne, French Guiana
    Curr Opin Infect Dis 19:443-9. 2006
    b>Histoplasmosis due to Histoplasma capsulatum var capsulatum is a frequent systemic fungal infection in the Americas. Diagnostic and therapeutic options differ between North and South America...
  20. pmc What is AIDS in the Amazon and the Guianas? Establishing the burden of disseminated histoplasmosis
    Mathieu Nacher
    centre d investigation clinique, Epidémiologie Clinique Antilles Guyane CIC EC CIE802, Centre Hospitalier de Cayenne
    Am J Trop Med Hyg 84:239-40. 2011
    ..A retrospective cohort study was thus conducted to describe the main AIDS-defining events in French Guiana. Disseminated histoplasmosis was the most frequent opportunistic infection (15.4/1000 person years).
  21. ncbi A multicenter evaluation of tests for diagnosis of histoplasmosis
    Chadi A Hage
    Pulmonary Critical Care Medicine, Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 53:448-54. 2011
    ..the MVista Histoplasma antigen enzyme immunoassay (MiraVista Diagnostics) has been evaluated in disseminated histoplasmosis in patients with AIDS and in the "epidemic" form of acute pneumonia...
  22. pmc Interleukins 17 and 23 influence the host response to Histoplasma capsulatum
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 200:142-51. 2009
    ..Generation of functional IL-17(+) cells is dependent on IL-6 and IL-10. Our findings also establish the existence a regulatory IL-17/IL-23 axis in histoplasmosis.
  23. ncbi Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells
    Alexandra I Medeiros
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Immunol 181:8544-51. 2008
    ..capsulatum against histoplasmosis was associated with increased LTB(4) and IFN-gamma production as well as recruitment of memory T cells into ..
  24. pmc Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Exp Med 197:1405-16. 2003
    ....
  25. ncbi Macrophages in host defense against Histoplasma capsulatum
    S L Newman
    Division of Infectious Diseases, University of Cincinnati College of Medicine, OH 45267 0560, USA
    Trends Microbiol 7:67-71. 1999
    ..Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host...
  26. pmc Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs
    George S Deepe
    Veterans Affairs Hospital, Cincinnati, OH, USA
    J Leukoc Biol 84:669-78. 2008
    ..These results reveal the complex nature of intracellular residence of this fungus. Moreover, the findings demonstrate that there is a skewing in the subpopulations of cells that are infected, especially DC...
  27. ncbi Histoplasmosis
    Kenneth S Knox
    University of Arizona College of Medicine and Southern Arizona VA HealthCare System, Tucson, Arizona, USA
    Proc Am Thorac Soc 7:169-72. 2010
    b>Histoplasmosis is the most prevalent endemic fungal infection in North America. The clinical spectrum ranges from asymptomatic, self-limited illness to a life-threatening progressive disseminated disease...
  28. pmc TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 180:1088-97. 2008
    ..with TNF-alpha antagonists is associated with serious infectious complications including disseminated histoplasmosis. The mechanisms by which inhibition of endogenous TNF-alpha alter protective immunity remain obscure...
  29. pmc A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis
    Livia Cristina Liporagi Lopes
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Vaccine Immunol 17:1155-8. 2010
    ..This further demonstrates the complexities of host-pathogen interactions...
  30. ncbi Gastrointestinal histoplasmosis in the acquired immunodeficiency syndrome: report of 18 cases and literature review
    Maha Assi
    Mayo Clinic, Rochester, MO, USA
    Diagn Microbiol Infect Dis 55:195-201. 2006
    No large case series of gastrointestinal histoplasmosis (GIH) in patients with AIDS has been published. We report 18 cases and review 34 published cases in the medical literature...
  31. ncbi Gastrointestinal histoplasmosis
    Charles J Kahi
    Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University Medical Center, UH 4100, 550 N University Boulevard, Indianapolis, IN 46202, USA
    Am J Gastroenterol 100:220-31. 2005
    Gastrointestinal histoplasmosis (GIH) is an uncommon disease with protean manifestations. It may occur as a result of mediastinal histoplasmosis or in the setting of progressive dissemination...
  32. pmc Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay
    L Joseph Wheat
    MiraVista Diagnostics, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 14:638-40. 2007
    ..results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection...
  33. pmc Phylogenetic relationships of varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum Darling
    T Kasuga
    Roche Molecular Systems, Alameda, California 94501, USA
    J Clin Microbiol 37:653-63. 1999
    ..Under a phylogenetic species concept based on possession of multiple shared derived characters, as well as concordance of four gene genealogies, H. capsulatum could be considered to harbor six species instead of three varieties...
  34. pmc The yeast-phase virulence requirement for α-glucan synthase differs among Histoplasma capsulatum chemotypes
    Jessica A Edwards
    Department of Microbiology, Center for Microbial Interface Biology, Ohio State University, 484 W 12th Avenue, Columbus, Ohio 43210, USA
    Eukaryot Cell 10:87-97. 2011
    ..In a murine model of histoplasmosis, the ags1(-) chemotype I mutant strains show no defect in lung infection or in extrapulmonary dissemination...
  35. ncbi Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 50:85-92. 2010
    Life-threatening histoplasmosis is one of the most common opportunistic infections in patients receiving tumor necrosis factor (TNF) blockers. Delays in considering the diagnosis may lead to increased morbidity and mortality...
  36. pmc Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis
    Alexandra I Medeiros
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, São Paulo 14040 903, Brazil
    Infect Immun 72:1637-44. 2004
    ..here the previously unreported role that leukotrienes play in the regulation of cytokines in a murine model of histoplasmosis. We demonstrate that administration of MK 886, a leukotriene synthesis inhibitor, caused Histoplasma ..
  37. ncbi Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis
    Guillaume Breton
    Department of Infectious and Tropical Diseases, Hopital Bichat Claude Bernard, Paris, France
    AIDS 20:119-21. 2006
    Four HIV-1-infected patients presented with unusual clinical manifestations in the course of disseminated histoplasmosis, including liver abscesses, compressive lymphadenitis, intestinal obstruction, uveitis and arthritis within a median ..
  38. ncbi FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence
    Donita R Croft
    The University of Iowa, Iowa City, IA, USA
    Lung Cancer 36:297-301. 2002
    ....
  39. ncbi Solitary parietal lobe histoplasmoma mimicking a brain tumor
    Niki I Paphitou
    Division of Infectious Diseases, The University of Texas Houston Medical School, 77030, USA
    Scand J Infect Dis 34:229-32. 2002
    ..Only a few cases of such intracranial histoplasmomas have been reported but this entity can mimic a brain neoplasm and should be a diagnostic consideration during the evaluation of ring-enhancing brain lesions...
  40. pmc Molecular detection of Histoplasma capsulatum var. capsulatum in human clinical samples
    Andrea Bracca
    Instituto de Biologia Molecular y Celular de Rosario, IBR CONICET, Facultad de Ciencias Bioquimicas y Farmaceuticas, 2000 Rosario, Argentina
    J Clin Microbiol 41:1753-5. 2003
    We developed a seminested PCR for the diagnosis of histoplasmosis that amplifies a portion of the Histoplasma capsulatum H antigen gene...
  41. ncbi Cell-mediated immunity to Histoplasma capsulatum
    S L Newman
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0560, USA
    Semin Respir Infect 16:102-8. 2001
    ..This review focuses on the immunology of host defense against H. capsulatum yeasts with emphasis on the development of cell-mediated immunity, and the strategies used by the fungus to survive and multiply within macrophages...
  42. ncbi Endobronchial histoplasmosis: a masquerade of primary endobronchial neoplasia--a clinical study of four cases
    Patrick Ross
    Department of Cardiothoracic Surgery, The Ohio State University, Columbus 43210, USA
    Ann Thorac Surg 78:277-81. 2004
    ..We encountered four patients with an endobronchial presentation of histoplasmosis masquerading as a bronchogenic malignancy.
  43. ncbi A case of primary cutaneous histoplasmosis in a patient with diabetes and multi-infarct dementia
    Aleksandar L Krunic
    Section of Dermatology, University of Chicago, Chicago, Illinois, USA
    J Dermatol 29:797-802. 2002
    We report a case of primary cutaneous histoplasmosis in a fifty-year-old African-American woman with diabetes and multi-infarct dementia...
  44. ncbi Histoplasma capsulatum molecular genetics, pathogenesis, and responsiveness to its environment
    Jon P Woods
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706 1532, USA
    Fungal Genet Biol 35:81-97. 2002
    ..b>Histoplasmosis may be considered the fungal homolog of the bacterial infection tuberculosis, since both H...
  45. ncbi Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis
    Kristel M L Crommentuyn
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Clin Infect Dis 38:e73-5. 2004
    ..and itraconazole in a patient infected with human immunodeficiency virus type 1 who had disseminated histoplasmosis. Coadministration of these agents led to a strong increase in itraconazole concentrations and a decrease in ..
  46. ncbi Presumed ocular histoplasmosis syndrome
    Anita G Prasad
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
    Curr Opin Ophthalmol 16:364-8. 2005
    Presumed ocular histoplasmosis syndrome remains a significant cause of visual morbidity. We review recent literature on the pathogenesis and particularly on the treatment of complications of presumed ocular histoplasmosis syndrome.
  47. pmc Histoplasmosis cluster, golf course, Canada
    Heather Anderson
    University of Alberta, Edmonton, Alberta, Canada
    Emerg Infect Dis 12:163-5. 2006
    We report a cluster of 4 cases of acute histoplasmosis (1 culture proven and 3 with positive serology, of which 2 were symptomatic) associated with exposure to soil during a golf course renovation...
  48. ncbi AIDS-related disseminated histoplasmosis in the greater Caribbean: how frequent is it?
    Mathieu Nacher
    AIDS 20:951-2. 2006
  49. ncbi Cervical abscess and mediastinal adenopathy: an unusual presentation of childhood histoplasmosis
    Elizabeth P McGraw
    Division of Pediatric Radiology, Department of Radiology, Box 3808, McGovern Davison Children s Health Center, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Radiol 32:862-4. 2002
    b>Histoplasmosis is the most common endemic respiratory mycosis in the United States...
  50. pmc Primary prophylaxis of disseminated histoplasmosis in HIV patients in French Guiana: arguments for cost effectiveness
    Mathieu Nacher
    Centre d Investigation Clinique Epidémiologie Clinique Antilles Guyane INSERM DGOS CIE 802, Centre Hospitalier de Cayenne, French Guiana Epidemiologie Parasitoses et Mycoses Tropicales, EA 3593, Universite Antilles Guyane, Cayenne, French Guiana Coordination Regionale de lutte contre le VIH, Centre Hospitalier de Cayenne, French Guiana Centre Hospitalier de l Ouest Guyanais, Saint Laurent du Maroni, French Guiana Laboratoire Hospitalo Universitaire de Parasitologie Mycologie, Centre Hospitalier de Cayenne, French Guiana Service de Dermatologie, Centre Hospitalier de Cayenne, French Guiana
    Am J Trop Med Hyg 89:1195-8. 2013
    b>Histoplasmosis is the first cause of acquired immunodeficiency syndrome (AIDS) and AIDS-related deaths in French Guiana...
  51. ncbi Dual time point positron emission tomography/computed tomography scan in evaluation of intrathoracic lesions in an area endemic for histoplasmosis and with high prevalence of sarcoidosis
    Dipen Kadaria
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine DK, ISA, axf, MKZ, University of Tennessee Health Science Center at Memphis, Tennessee and Veterans Affairs Medical Center DSA, ISA, DSW, MKZ, Memphis, Tennessee
    Am J Med Sci 346:358-62. 2013
    ..We explored the role of dual time point fluorodeoxyglucose positron emission tomography/computed tomography (DTP PET/CT) scan in the differentiation of benign and malignant lung and mediastinal lesions...
  52. ncbi Isolated Histoplasma capsulatum meningoencephalitis in an immunocompetent child
    Zachary D Threlkeld
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536 0281, USA
    J Child Neurol 27:532-5. 2012
    b>Histoplasmosis with central nervous system involvement typically arises in the immunocompromised patient with disseminated fungal disease...
  53. pmc Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay
    Chadi A Hage
    Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Pulmonary Critical Care Medicine, Indianapolis, Indiana 46202, USA
    Clin Vaccine Immunol 18:661-6. 2011
    ..Clearance of Histoplasma antigen has been used as a marker for response to treatment of progressive disseminated histoplasmosis (PDH) in patients with AIDS...
  54. ncbi Bilateral adrenal histoplasmosis in immunocompetent patients
    Chanchal Rana
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Diagn Cytopathol 39:294-6. 2011
    b>Histoplasmosis is a fungal infection caused by Histoplasma capsulatum, which commonly presents as transient pulmonary infection that usually subsides without treatment...
  55. ncbi Biopsy findings in acute pulmonary histoplasmosis: unusual histologic features in 4 cases mimicking lymphomatoid granulomatosis
    Sanjay Mukhopadhyay
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, 13210, USA
    Am J Surg Pathol 34:541-6. 2010
    Most examples of pulmonary histoplasmosis, including histoplasmoma and chronic histoplasmosis, are characterized by typical necrotizing granulomatous inflammation...
  56. pmc Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis
    F J Gomez
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0560, USA
    J Clin Invest 102:984-95. 1998
    ..The identification of clonotypes of Vbeta4(+) cells suggests that a few antigenic determinants may drive proliferation of this subset, which is necessary for optimal clearance...
  57. ncbi An outbreak of histoplasmosis in the city of Blumenau, Santa Catarina
    Flávio de Mattos Oliveira
    Santa Casa Hospital Mycology Laboratory, Porto Alegre, RS, Brazil
    J Bras Pneumol 32:375-8. 2006
    Acute pulmonary histoplasmosis is rarely diagnosed and is often confused with tuberculosis...
  58. ncbi Gr-1+ cells play an essential role in an experimental model of disseminated histoplasmosis
    Anderson Sá-Nunes
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Café s no, Ribeirao Preto, São Paulo 14040 903, Brazil
    Microbes Infect 9:1393-401. 2007
    ..Depletion of Gr-1(+) cells using the monoclonal antibody (MAb) RB6-8C5 increased histoplasmosis severity and inhibited the subsequent development of a protective immune response...
  59. ncbi [Primary cutaneous histoplasmosis: case report on an immunocompetent patient and review of the literature]
    Mauricio Naoto Saheki
    Servico de Infectologia, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Rev Soc Bras Med Trop 41:680-2. 2008
    This report describes a case of primary cutaneous histoplasmosis in a 45-year-old male...
  60. ncbi Study of 30 cases of histoplasmosis observed in the Mato Grosso do Sul State, Brazil
    Marilene Rodrigues Chang
    Departamento de Farmácia e Bioquímica, Universidade Federal de Mato Grosso do SulMS, Brasil
    Rev Inst Med Trop Sao Paulo 49:37-9. 2007
    Thirty cases of histoplasmosis observed at the University Hospital of the Federal University of Mato Grosso do Sul (HU-UFMS) from January 1998 to December 2005 are reported. Most (83.3%) of the patients were men, average 33...
  61. ncbi [Histoplasmosis: uncommon opportunistic infection in a patient with HIV infection]
    M Escher
    Gastroenterologie, Hepatologie und Endokrinologie, Innere Medizin I, Robert Bosch Krankenhaus, Stuttgart, Germany
    Dtsch Med Wochenschr 137:260-4. 2012
    ..A 19-year-old HIV-positive man was admitted with fever of unknown origin and poor general condition. Antiretroviral therapy had been stopped by the patient eight months prior to admission...
  62. pmc Indigenous case of disseminated histoplasmosis, Taiwan
    Chung Hsu Lai
    E Da Hospital and I Shou University, Kaohsiung County, Taiwan, Republic of China
    Emerg Infect Dis 13:127-9. 2007
    We report the first indigenous case of disseminated histoplasmosis in Taiwan diagnosed by histopathology of bone marrow, microbiologic morphology, and PCR assay of the isolated fungus...
  63. ncbi Diagnosis of histoplasmosis by antigen detection in BAL fluid
    Chadi A Hage
    Department of Medicine, Roudebush VA Medical Center, Indiana University, Indianapolis, IN 46202, USA
    Chest 137:623-8. 2010
    Detection of antigen in BAL is useful for diagnosis of histoplasmosis. The MVista Histoplasma antigen enzyme immunoassay has been modified to permit quantification...
  64. ncbi Disseminated cutaneous histoplasmosis in an immunocompetent child, relapsed with itraconazole, successfully treated with voriconazole
    Jyoti Dhawan
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
    Pediatr Dermatol 27:549-51. 2010
    We present a rare case of disseminated cutaneous histoplasmosis in an immunocompetent child who relapsed after treatment with amphotericin B followed by itraconazole and was successfully treated with voriconazole.
  65. pmc Imported acquired immunodeficiency syndrome-related histoplasmosis in metropolitan France: a comparison of pre-highly active anti-retroviral therapy and highly active anti-retroviral therapy eras
    Vincent Peigne
    Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Paris, France
    Am J Trop Med Hyg 85:934-41. 2011
    ..Clinical presentation and outcome of acquired immunodeficiency syndrome-related histoplasmosis are unknown in non-endemic areas with wide access to highly active anti-retroviral therapy (HAART)...
  66. ncbi A large histoplasmosis outbreak among high school students in Indiana, 2001
    Shadi Chamany
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS C09, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 23:909-14. 2004
    A histoplasmosis outbreak occurred in an Indiana high school in November-December 2001.
  67. ncbi Chronic cavitary pulmonary histoplasmosis
    José Wellington Alves dos Santos
    Department of Pulmonology, Santa Maria University Hospital, Federal University of Santa Maria, Santa Maria, Brazil
    J Bras Pneumol 35:1161-4. 2009
    b>Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum, which can be isolated from soil contaminated with droppings from birds or bats...
  68. ncbi Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors
    Pierre Couppie
    Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, French Guiana
    Clin Infect Dis 38:134-8. 2004
    We aimed to identify prognostic factors for AIDS-associated disseminated histoplasmosis. In a multivariate analysis, we found that dyspnea, a platelet count of <100,000 platelets/mm3, and lactate dehydrogenase levels of >2 times the ..
  69. ncbi [Investigation on the epidemiology of Histoplasma capsulatum infection in Nanjing district]
    B Zhao
    Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Command
    Zhonghua Liu Xing Bing Xue Za Zhi 19:215-7. 1998
    ..90% subjects reacted to both histoplasmin and PPD, 7.88% of the research subjects reacted to histoplasmin but not to PPD. Result suggested that there was herd infection of Histoplasma capsulatum in Nanjing district...
  70. pmc Efficacy of ravuconazole in treatment of systemic murine histoplasmosis
    K V Clemons
    California Institute for Medical Research Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA
    Antimicrob Agents Chemother 46:922-4. 2002
    ..for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis. All regimens tested prolonged survival (P < 0.05 to 0.0001)...
  71. ncbi [Fatal miliary tuberculosis in an HIV-infected Cameroon woman: disseminated histoplasmosis due to Histoplasma capsulatum capsulatum]
    C E Mandengue
    Service de Medecine Interne, Hopital General, Yaounde, Cameroun
    Med Trop (Mars) 71:615-7. 2011
    The purpose of this report is to describe the first Cameroonian case of disseminated histoplasmosis due to Histoplasma capsulatum capsulatum in association with HIV infection. The patient was a 34-year-old HIV1 infected woman...
  72. ncbi Histoplasmosis in the nasal septum without pulmonary involvement in a patient with acquired immunodeficiency syndrome: case report and literature review
    Fernando Oikawa
    Hospital Municipal de Campo Limpo Dr Fernando Mauro Pires da Rocha, Sao Paulo, SP, Brazil
    Sao Paulo Med J 128:236-8. 2010
    b>Histoplasmosis is a fungal disease caused by inhaling spores of the fungus Histoplasma capsulatum. The spores can be found in soil contaminated with bird, bat or chicken feces...
  73. ncbi Effect of CD40 ligand on the course of murine histoplasmosis
    L J Wheat
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Med Mycol 40:501-5. 2002
    ..The purpose of this study was to examine the role of CD40L in recovery from histoplasmosis using a murine model of intratracheally induced infection...
  74. ncbi Ileocecal histoplasmosis simulating Crohn disease in a patient with hyperimmunoglobulin E syndrome
    Steven J Steiner
    Division of Pediatric Gastroenterology Hepatology Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202 5225, USA
    Pediatr Infect Dis J 28:744-6. 2009
    ..Histopathologic findings of the terminal ileum demonstrated intracellular yeast forms compatible with Histoplasma capsulatum. The patient was treated with oral itraconazole and had a rapid and complete response...
  75. ncbi Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum
    G S Deepe
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, OH 45267, USA
    J Immunol 163:4985-93. 1999
    We examined the influence of endogenous GM-CSF on the course of primary and secondary pulmonary histoplasmosis. A high proportion (>/=75%) of C57BL/6 mice given mAb to GM-CSF did not survive primary infection, whereas 88-94% of ..
  76. ncbi Mucocutaneous histoplasmosis in HIV with an atypical ecthyma like presentation
    Vandana Mehta
    Department of Skin and STD, Kasturba Medical College, Manipal, Karnataka, India
    Dermatol Online J 15:10. 2009
    Pulmonary and disseminated forms of histoplasmosis are very common in AIDS, but primary cutaneous histoplasmosis is rare. We report a case of primary mucocutaneous histoplasmosis in the setting of HIV.
  77. ncbi HIV-associated histoplasmosis in French Guiana: recent infection or reactivation?
    Matthieu Hanf
    Centre d Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC EC CIE 802, Cayenne General Hospital, Ehpad, Cayenne, French Guiana, France
    AIDS 24:1777-8. 2010
    In order to determine whether HIV-associated disseminated histoplasmosis was a recent infection or a reactivation, time series of first episodes of disseminated histoplasmosis were analyzed...
  78. ncbi Prostatic and central nervous system histoplasmosis in an immunocompetent host: case report and review of the prostatic histoplasmosis literature
    S D Mawhorter
    Department of Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Infect Dis 30:595-8. 2000
    b>Histoplasmosis is a common cause of systemic mycosis in areas of the United States where it is endemic. Central nervous system and genitourinary histoplasmosis is rare, especially in immunocompetent hosts...
  79. ncbi Histoplasmosis diagnosis using a polymerase chain reaction method. Application on human samples in French Guiana, South America
    Danièle Maubon
    Laboratoire Hospitalo universitaire de Parasitologie et Mycologie Médicale, Equipe EA 3593, UFR de Médecine de l Université des Antilles et de la Guyane, Campus Saint Denis, BP 718, 97336 Cayenne, Guyane Francaise, France
    Diagn Microbiol Infect Dis 58:441-4. 2007
    Untreated histoplasmosis is life threatening, especially in immunosuppressed patients. In French Guiana, South America, it is one of the most common opportunistic infections in AIDS patients...
  80. ncbi Regulation of infection with Histoplasma capsulatum by TNFR1 and -2
    R Allendoerfer
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 165:2657-64. 2000
    ..The results demonstrate the pivotal influence of TNFR1 and -2 in controlling primary infection and highlight the differences between these receptors for regulation reexposure histoplasmosis.
  81. ncbi [A primary investigation on disseminated histoplasmosis in Hubei]
    Xia Li
    The Clinic Laboratory of Zhongnan Hospital of Wuhan University, Wuhan 430071, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:708-10. 2003
    To investigate the epidemiologic features of disseminated histoplasmosis (PDH) in Hubei province.
  82. ncbi Acute disseminated histoplasmosis complicated with hypercalcaemia
    J W Liu
    Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung, Kaohsiung Hsien, Taiwan, Republic of China
    J Infect 39:88-90. 1999
    A case of acute progressive disseminated histoplasmosis complicated with hypercalcemia is reported and the literature is reviewed...
  83. ncbi Histoplasmosis of the tibia
    Bryce A Palmgren
    University of Kansas School of Medicine Wichita, Wichita, Kan, USA
    Orthopedics 28:67-8. 2005
  84. ncbi Histoplasmosis clinically imitating cutaneous malignancy
    Nicholas Golda
    Department of Dermatology, University of Missouri Columbia, Columbia, MO 65212, USA
    J Cutan Pathol 35:26-8. 2008
    Disseminated histoplasmosis can have a varied presentation when it affects the skin. Presentation mimicking a cutaneous neoplasm is an uncommon manifestation...
  85. ncbi Disseminated histoplasmosis in an immunocompetent individual--a case report
    Seema Sharma
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP
    Indian J Pathol Microbiol 48:204-6. 2005
    We report a rare case of disseminated histoplasmosis in a immunocompetent young adult person involving bone marrow, liver, spleen and oral cavity. He presented with oral ulcers, weight loss and pancytopenia...
  86. ncbi Histoplasmosis and paracoccidioidomycosis in a non-endemic area: a review of cases and diagnosis
    Maria J Buitrago
    Servicio de Micologia, Instituto de Salud Carlos III, Carretera Majadahonda Pozuelo Km 2, Majadahonda, Madrid, Spain
    J Travel Med 18:26-33. 2011
    b>Histoplasmosis and paracoccidioidomycosis (PCM) have increased in Spain in recent years, due firstly to the migration from endemic regions and secondly to travelers returning from these regions...
  87. ncbi Hypercalcemia in histoplasmosis aggravated with antifungal treatment
    Elie Chalhoub
    University of Kansas School of Medicine UKSM Wichita, Kansas 67214, USA
    J Med Liban 60:165-8. 2012
    Hypercalcemia is a known, but rare complication of histoplasmosis, a granulomatous disease...
  88. ncbi Disseminated histoplasmosis presenting as pyoderma gangrenosum-like lesions in a patient with acquired immunodeficiency syndrome
    P Laochumroonvorapong
    Department of Dermatology, Division of Dermatopathology, New York Presbyterian Hospital, 525 East 68th Street, F 342, New York, NY 10021, USA
    Int J Dermatol 40:518-21. 2001
    ..lesions of molluscum contagiosum, other infectious processes considered in the differential diagnosis included histoplasmosis, cryptococcosis, and Penicillium marnefei...
  89. ncbi Pharyngo-laryngeal histoplasmosis: one case in an immunocompetent child
    T Coiffier
    Department of Pediatric ENT and Cervico Facial Surgery, Trousseau Children s Hospital, Paris, France
    Int J Pediatr Otorhinolaryngol 45:177-81. 1998
    We report a very rare case of disseminated pharyngo-laryngeal histoplasmosis with systemic spread in a 10-year-old, immunocompetent child from Guyana...
  90. ncbi Endemic mycoses: blastomycosis, histoplasmosis, and sporotrichosis
    Carol A Kauffman
    University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Infect Dis Clin North Am 20:645-62, vii. 2006
    ..This article discusses histoplasmosis and blastomycosis...
  91. ncbi Diagnosis of histoplasmosis in immunosuppressed patients
    Carol A Kauffman
    Division of Infectious Diseases, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
    Curr Opin Infect Dis 21:421-5. 2008
    To define the most appropriate studies for making a diagnosis of histoplasmosis in immunosuppressed patients.
  92. ncbi Primary localized histoplasmosis with lesions restricted to the mouth in a Chinese HIV-negative patient
    Lan Ge
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
    Int J Infect Dis 14:e325-8. 2010
    b>Histoplasmosis is a deep mycosis caused by Histoplasma capsulatum, which is endemic in many areas of the world but is relatively rare in China...
  93. ncbi Recurrent histoplasmosis of the wrist: a case report
    S B Care
    Department of Orthopaedic Surgery, University Hospitals of Cleveland, OH, USA
    J Hand Surg Am 23:1112-4. 1998
    b>Histoplasmosis of the extremities is rare. A case of recurrent histoplasmosis with a 10-year latency between initial presentation and clinical recurrence is reported...
  94. pmc Head and neck histoplasmosis--a nightmare for clinicians and pathologists! Experience at a tertiary referral cancer centre
    Seethalakshmi Viswanathan
    Department of Pathology, Head and Neck Services, Tata Memorial Hospital, Dr E Borges Road, Parel, Mumbai, India
    Head Neck Pathol 1:169-72. 2007
    b>Histoplasmosis is a rarely reported deep mycotic infection in the Indian context...
  95. ncbi Indigenous case of disseminated histoplasmosis from the Penicillium marneffei endemic area of China
    Cunwei Cao
    Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province, People s Republic of China
    Mycopathologia 170:47-50. 2010
    This is the first indigenous case of disseminated histoplasmosis reported from the Penicillium marneffei endemic area in southern China...
  96. ncbi Epidemiological investigation of Histoplasma capsulatum infection in China
    B Zhao
    Respiratory Department, Nanjing General Hospital of Nanjing Military Area Command PLA, Nanjing 210002, China
    Chin Med J (Engl) 114:743-6. 2001
    ..To provide reliable information concerning the presence or the absence of Histoplasma capsulatum (H. capsulatum) infection in China, and data concerning this respect...
  97. ncbi Efficacy of cell-free antigens in evaluating cell immunity and inducing protection in a murine model of histoplasmosis
    Anderson Sá-Nunes
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Café s n o, Ribeirao Preto, SP 14040 903, Brazil
    Microbes Infect 7:584-92. 2005
    ..cell-free antigens (CFAgs) and observed their efficacy in evaluating cellular immunity during murine histoplasmosis. CFAgs induced a more potent delayed-type hypersensitivity (DTH) response in H...
  98. pmc Molecular evidence of recurrent histoplasmosis with 9-year latency in a patient with Addison's disease
    Tai Chung Tseng
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei
    J Clin Microbiol 43:4911-3. 2005
    We present a case of fatal histoplasmosis in a patient with Addison's disease and long-term use of corticosteroid. The patient acquired Histoplasma capsulatum in China and initially presented with a laryngeal mass...
  99. ncbi Chapter 4--histoplasmosis
    Miguel Abidon Aidê
    Fluminense Federal University, Niteroi, Brazil
    J Bras Pneumol 35:1145-51. 2009
    b>Histoplasmosis is systemic mycosis caused by a small fungus, Histoplasma capsulatum var. capsulatum, whose natural habitat is soil contaminated by bat or bird excrement. The incidence of histoplasmosis is worldwide...
  100. ncbi [Disseminated histoplasmosis with involvement of mediastinum and skin in an immunocompetent patient]
    R Wobser
    Abteilung für Nephrologie und Allgemeinmedizin, Medizinische Klinik IV, Universitatsklinikum Freiburg, Hugstetterstrasse 55, Freiburg
    Dtsch Med Wochenschr 134:589-93. 2009
    ..A 29-years-old Brazilian woman was admitted to hospital because of progressive dyspnoea, shivering and fever. She reported a noticeable swelling at the right mandible and an ulcerative tumor at the side of the nose...
  101. ncbi [Histoplasmosis 45 years after infection in an immunocompetent man]
    Josep M Torres-Rodríguez
    Unitat de Recerca en Malalties Infeccioses i Micologia, Unidad Docente del IMAS, Facultad de Medicina, Universitat Autonoma de Barcelona, Barcelona, Espana
    Rev Iberoam Micol 26:244-6. 2009
    We report a case of a lung reactivation of a latent histoplasmosis in a 68-year-old patient without immunologic dysfunction living in Barcelona (Spain). The Histoplasma capsulatum var...

Research Grants64

  1. Histoplasma Gene Expression and Organism Persistence
    ALAN GEORGE SMULIAN; Fiscal Year: 2012
    ..Reactivation of dormant infection is the most common mechanism of clinically evident histoplasmosis and often arises in the context of a weakened immune system...
  2. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  3. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..with an emphasis on clarifying the extent to which Th17 cells persist after vaccination to blastomycosis, histoplasmosis, and coccidioidomycosis...
  4. Point-of-care immunoassay for diagnosis of histoplasmosis in HIV/AIDS
    Sean Bauman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Progressive disseminated histoplasmosis is a common and life-threatening fungal infection among patients with HIV/AIDS in the United States and Latin America...
  5. Regional Variation of FDG-PET Scans to diagnose lung cancer
    Eric L Grogan; Fiscal Year: 2013
    ..Retrospective single institution studies have demonstrated that infectious fungal lung diseases, such as histoplasmosis, reduce the specificity FDG- PET scans to diagnose lung cancer...
  6. Glucan Particles as a Vaccine Platform for Protective Immunity
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..vaccinated with GPs containing antigen from Histoplasma capsulatum (Hc) survive otherwise lethal experimental histoplasmosis. The experiments will address the central hypothesis that antigen-loaded GPs make effective vaccine platforms ..
  7. GM-CSF Regulation of Zinc in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..Killing of yeasts by stimulated macrophages is mediated by zinc starvation. We seek to determine how zinc depletion occurs so that these findings can offer new avenues for treatment of this fungus. ..
  8. MOLECULAR MECHANISMS OF HISTOPLASMA PATHOGENESIS
    William E Goldman; Fiscal Year: 2011
    ..Characterize the role of other putative virulence factors in histoplasmosis. Two of these virulence-associated genes contribute to the ability of H. capsulatum to adhere to macrophages...
  9. Molecular and Cellular Determinants of Immunity to Histoplasmosis
    George S Deepe; Fiscal Year: 2013
    ..effect of the absence of CCR5 in mice lacking TNF-a are particularly germane to reports of progressive histoplasmosis in patients receiving TNF antagonists...
  10. Virulence factor discovery in the secreted proteome of Histoplasma capsulatum
    Chad A Rappleye; Fiscal Year: 2012
    ..in culture to assess intracellular parasitism and will be employed in animal infection models of respiratory histoplasmosis. These experiments are designed to assess the contribution of individual factors in Histoplasma pathogenesis...
  11. Myeloid Cell KLF2 and IL-4 in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: This grant seeks to understand the role of a transcription factor immunity to histoplasmosis. The gene known as Kr[unreadable]ppel like factor regulates production of molecules that are necessary for the ..
  12. Role and Regulation of a Molecular Mimic in Histoplasma Pathogenesis
    William E Goldman; Fiscal Year: 2013
    ..identified fungal member of the large and diverse saposin-like protein family, its precise mechanistic role in histoplasmosis remains unproven...
  13. Improving the Diagnosis of Histoplasmosis in an Endemic Region
    Kathleen R Page; Fiscal Year: 2011
    b>Histoplasmosis and tuberculosis (TB) are endemic in Central America and are the two most common opportunistic infections in HIV-infected patients...
  14. Molecular dissection of Histoplasma-induced host-cell death
    Anita Sil; Fiscal Year: 2013
    ..human macrophages, and (4) assess the role of Cbp1 in host-cell death and inflammation in the mouse model of histoplasmosis. These studies will generate new paradigms of virulence strategies used by human fungal pathogens during ..
  15. 2010 Cell and Molecular Fungal Biology; Gordon Research Conference
    John W Taylor; Fiscal Year: 2010
    ..transplant patients, candidiasis and aspergillosis, and the systemic fungal diseases, coccidioidomycosis and histoplasmosis. The health relatedness of this application concerns both the role that fungi play in human disease and the ..
  16. Interhemispheric Research/Training in Infectious Disease
    HERBERT BERNARD TANOWITZ; Fiscal Year: 2013
    ..The diseases included in this training program are: fungal diseases (i.e., histoplasmosis, sporotrichosis) parasitic diseases (Chagas disease, toxoplasmosis and malaria) and bacterial diseases (..
  17. 2012 Cellular and Molecular Fungal Biology Gordon Research Conference
    Judith G Berman; Fiscal Year: 2012
    ..patients, candidiasis, cryptococcosis and aspergillosis, as well as systemic fungal diseases such as histoplasmosis. PUBLIC HEALTH RELEVANCE: Project Narrative: The health relatedness of this application concerns both the role ..
  18. SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTER
    Susan Bressler; Fiscal Year: 2003
    ..surgical removal of choroidal neovascular lesions secondary to age-related macular degeneration, ocular histoplasmosis, and unknown causes in four randomized clinical trials, each for a different lesion type and presumed etiology...
  19. MURINE MODEL OF IMMUNOSUPPRESSION INDUCED CMV RETINITIS
    Patrick Cleveland; Fiscal Year: 1991
    ..Toxoplasmosis, Candida, Mycobacterium, herpes simplex herpes simplex virus, varicella zoster virus, histoplasmosis, and syphilis which have been reported in the retina of AIDS CM rarely causes retinitis in healthy adults...
  20. A NOVEL TARGET FOR THE DEVELOPMENT OF ANTIFUNGAL AGENTS
    Corey Nislow; Fiscal Year: 2001
    ..Abstract): The increase in opportunistic fungal infections such as candidiasis, zygomycosis, cryptococcosis, histoplasmosis, and Aspergillus and Fusarium infections in immunocompromised individuals, including AIDS patients, the ..
  21. INTERACTION OF H CAPSULATUM WITH ALVEOLAR MACROPHAGE
    Simon Newman; Fiscal Year: 1999
    ..Although the course of infection is mild in most immunocompetent individuals, disseminated histoplasmosis is seen with increasing frequency as a complication of AIDS, particularly in areas where Hc is endemic...
  22. Actin-binding proteins as novel antifungal targets
    Corey Nislow; Fiscal Year: 2001
    The increase in opportunistic fungal infections such as candidiasis, zygomycosis, cryptococcosis, histoplasmosis, and Aspergillus and Fusarium infections in immunocompromised individuals, including AJDS patients, the elderly, surgical ..
  23. IFN-GAMMA IN EXPERIMENTAL MURINE HISTOPLASMOSIS
    BETTY WU HSIEH; Fiscal Year: 1991
    ..macrophages cultured in vitro has been studied as a cellular model of the host-parasite interaction in histoplasmosis. Peritoneal macrophages from mice immunized by sublethal infection restrict the intracellular growth of H...
  24. APPLICATIONS OF IRON COMPLEXES TO ORGANIC SYNTHESIS
    William Donaldson; Fiscal Year: 2001
    ..This compound was found to be orally active against systemic infections of histoplasmosis and coccidiomycosis...
  25. Interaction of H. capsulatum with Dendritic Cells
    Simon Newman; Fiscal Year: 2006
    ..3) To determine if Hc antigen-pulsed DC confer protective immunity in a murine model of pulmonary histoplasmosis, and to define the immunologic parameters of protective immunity in immunocompetent and immunocompromised mice...
  26. MOLECULAR PATHOGENESIS OF PULMONARY HISTOPLASMOSIS
    JON WOODS; Fiscal Year: 2004
    ..b>Histoplasmosis is the most common endemic mycoses in the world and is particularly dangerous for immunocompromised patients...
  27. ANTIMICROBIAL THERAPY OF SYSTEMIC MYCOTIC DISEASES
    William Dismukes; Fiscal Year: 1990
    ..the therapy of cryptococcal meningitis and various forms of aspergillosis, coccidioidomycosis, blastomycosis, histoplasmosis, and candidiasis. Currently accepted "standard" regimens will be compared against innovative new regimens...
  28. RAS GENE FUNCTION IN FUNGAL DIMORPHISM
    JUDITH MEDOFF; Fiscal Year: 1990
    ..H. capsulatum is the causative agent of the disease, histoplasmosis, one of the most common primary systemic fungal infections in the Western Hemisphere...
  29. INTERACTION OF H CAPSULATUM WITH MACROPHAGES AND PMN
    Simon Newman; Fiscal Year: 2000
    ..The results of these studies should provide significant insight into the pathogenesis of histoplasmosis and aid in the design of new drugs for treatment.
  30. SUBMACULAR SURGERY TRIALS--STUDY CHAIRMAN'S OFFICE GRANT
    NEIL BRESSLER; Fiscal Year: 2005
    ..which is the most prevalent cause of irreversible severe vision loss in Americans over 65, ocular histoplasmosis, and unknown causes in four randomized clinical trials, each for a different lesion type and presumed etiology...
  31. Genomic Resources for Histoplasma capsulatum
    Elaine Mardis; Fiscal Year: 2002
    ..H. capsulatum, the etiologic agent of histoplasmosis, is a primary fungal pathogen that is endemic in the Ohio River Valley through the midwestern United States ..
  32. Stromal Gene Expression During Pulmonary Sarcoidosis
    Elliott Crouser; Fiscal Year: 2005
    ..Determine If Gene Expression Patterns Will Differentiate Granuloma Caused By Sarcoidosis From Those Caused by Histoplasmosis. Gene expression patterns will be generated from total RNA derived from tissue samples of adults with newly ..
  33. MOLECULAR BASES OF INTERFERON-INDUCED FUNGISTATIS
    DEXTER HOWARD; Fiscal Year: 1993
    ..would be useful in developing immune therapeutic strategies for controlling progressive, disseminated forms of histoplasmosis in which recovery is not the rule...
  34. IMMUNOREGULATION IN DISSEMINATED HISTOPLASMOSIS
    WARD BULLOCK; Fiscal Year: 1990
    ..Similar studies will be performed on cells by bronchoalveolar lavage of patients with pulmonary histoplasmosis.
  35. H. CAPSULATUM-REACTIVE MURINE T CELL CLONES AND HYBRIDS
    GEORGE DEEPE; Fiscal Year: 1991
    ..In addition, studies will be conducted to determine if clonotypic antibodies can modify experimental histoplasmosis in mice or if it can vaccinate mice against Histoplasma infection...
  36. MACULAR PHOTOCOAGULATION STUDY
    RAYMOND MARGHERIO; Fiscal Year: 1993
    Senile macular degeneration is a leading cause of blindness in the United States and presumed ocular histoplasmosis syndrome, while less common, is an important cause of blindness...
  37. MACULAR PHOTOCOAGULATION STUDY
    THOMAS BURTON; Fiscal Year: 1993
    ..of the photocoagulation of subretinal neovascular membranes in senile macular degeneration and presumed ocular histoplasmosis. The objectives in presumed ocular histoplasmosis are: A) To determine by means of a randomized controlled ..
  38. INTERACTIONS OF HUMAN ENDOTHELIAL CELLS WITH HISTOPLASMA
    RAM TEWARI; Fiscal Year: 1990
    b>Histoplasmosis is a respiratory fungal disease with significant morbidity and mortality, and also has been recently recognized with increasing frequency in patients with acquired immunodeficiency syndrome (AIDS)...
  39. Dimorphism related genes in Histoplasma capsulatum
    Glenmore Shearer; Fiscal Year: 2001
    ..Yeast/mold dimorphism in Histoplasma capsulatum (Hc) is critical to the pathogenesis of the lung disease histoplasmosis which infects an estimated 500,000 Americans each year...
  40. MACULAR PHOTOCOAGULATION STUDY
    Michael Klein; Fiscal Year: 1993
    ..in the treatment of subretinal neovascularization occurring in senile macular degeneration, presumed ocular histoplasmosis, and idiopathic subretinal neovascularization...
  41. INTRAVITREAL FLUOCINOLONE IMPLANT MACULAR DEGENERATION
    Paul Ashton; Fiscal Year: 1999
    ..in animals and is presently in Phase I human studies for uveitis and recurrent sub-macular membranes in histoplasmosis. The clinical protocols will be carried out in the Clinical Trials Branch of the National Eye Institute...
  42. H. CAPSULATUM INTERACTIONS WITH MURINE MACROPHAGES
    J Little; Fiscal Year: 1991
    ..Epidemiological data indicate that histoplasmosis occurs throughout the world but it is endemic in the central U.S...
  43. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..that one antigen from Hc, recombinant heat shock protein (rhsp) 60, is immunogenic in murine models of histoplasmosis. We also have shown that the protective activity of this antigen requires the presence of CD4 [unreadable], ..
  44. MACULAR PHOTOCOAGULATION STUDY
    Suresh Chandra; Fiscal Year: 1993
    Senile macular degeneration is a leading cause of blindness in the United States, and presumed ocular histoplasmosis syndrome, while less common, is an important cause of blindness...
  45. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..Project 3 headed by Dr. Deepe will examine the immunologic mechanisms that underpin reactivation histoplasmosis. This form of infection is thought to be one of the important means by which immunosuppressed as well as ..
  46. MACULAR PHOTOCOAGULATION STUDY
    JAMES FOLK; Fiscal Year: 1993
    ..are: 1) to extend our knowledge of the natural history of choroidal neovascular membranes in eyes with ocular histoplasmosis, senile macular degeneration and idiopathic macular degeneration, 2) to improve our information on the natural ..
  47. MACULAR PHOTOCOAGULATION STUDY
    Mary Lewis; Fiscal Year: 1993
    ..membranes using argon laser photocoagulation is useful in preserving visual acuity in eyes with ocular histoplasmosis or senile macular degeneration. B...
  48. Lung Image Database with Pathologic Correlates
    Geoffrey McLennan; Fiscal Year: 2006
    ..a well characterized group of study subjects with lung cancer, and with common lung cancer mimics such as histoplasmosis, supported by excellent radiologists and pathologists. expertise in the development of CT imaging protocols...
  49. MACULAR PHOTOCOAGULATION STUDY
    Lawrence Singerman; Fiscal Year: 1993
    ..Particularly applicable is Chapter 2, Research Plan. This includes: 2.1.1. Objectives - ocular histoplasmosis; 2.1.2. Objectives - senile macular; 2.3. Major design characteristics.
  50. OCULAR CLINICO-PATHOLOGIC CORRELATION
    William Green; Fiscal Year: 1980
    ..We have conducted clinicopathologic studies of eyes from 36 patients in programs 2 and 3. We have gained an exceptional fund of information on senile macular degeneration, the ocular histoplasmosis syndrome and degenerative myopia.
  51. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  52. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..Despite the use of potent anti-fungal medications significant morbidity and mortality from histoplasmosis continues to occur, and current treatment regimens frequently fail to eradicate the organism in immuno-..
  53. ADULT AIDS CLINICAL TRIALS UNIT
    Mitchell Goldman; Fiscal Year: 2008
    ..Specialized immunology, virology, and pharmacology laboratories will support this work. ..
  54. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Subfoveal CNV may also occur in the ocular histoplasmosis syndrome (OHS), leading to disability in young adults...
  55. JCV Virus Expression in Oropharynx and HIV
    Joseph Berger; Fiscal Year: 2004
    ..This line of investigation would add credence to an oropharyngeal mechanism of JCV transmission and may ultimately lead to the clinical identification of an acute illness attributable to this pathogen. ..
  56. NEUROLOGIC/IMMUNOLOGIC MANIFESTATION OF HTLV-I INFECTION
    Joseph Zunt; Fiscal Year: 2004
    ....
  57. Histoplasma capsulatum Iron Acquisition and Utilization
    JON WOODS; Fiscal Year: 2006
    ..3) Identify other Hc structural, biosynthetic, and regulatory genes involved in iron acquisition by molecular genetic approaches and determine their importance in Hc intracellular infection. ..
  58. Retrovial Infections of the Nervous System in Peru
    JOSEPH RAYMOND ZUNT; Fiscal Year: 2010
    ..In addition to continuing our investigations, we plan to continue training activities to address the research, education, training, and mentoring needs and opportunities related to CNS infection identified during the R21 planning grant. ..