candidiasis

Summary

Summary: Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)

Top Publications

  1. pmc Epidemiology of invasive candidiasis: a persistent public health problem
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Microbiol Rev 20:133-63. 2007
  2. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
  3. ncbi Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America
    Peter G Pappas
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 48:503-35. 2009
  4. ncbi Growth of Candida albicans hyphae
    Peter E Sudbery
    Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, UK
    Nat Rev Microbiol 9:737-48. 2011
  5. pmc Candida albicans morphogenesis and host defence: discriminating invasion from colonization
    Neil A R Gow
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nat Rev Microbiol 10:112-22. 2012
  6. pmc Candida albicans secreted aspartyl proteinases in virulence and pathogenesis
    Julian R Naglik
    Department of Oral Medicine, Pathology and Immunology, GKT Dental Institute, Kings College London, London, United Kingdom
    Microbiol Mol Biol Rev 67:400-28, table of contents. 2003
  7. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
  8. ncbi Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment
    Michael A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med 125:S3-13. 2012
  9. ncbi An integrated model of the recognition of Candida albicans by the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Microbiol 6:67-78. 2008
  10. ncbi Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku Tokyo 108 8639, Japan
    Immunity 32:681-91. 2010

Detail Information

Publications353 found, 100 shown here

  1. pmc Epidemiology of invasive candidiasis: a persistent public health problem
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Microbiol Rev 20:133-63. 2007
    Invasive candidiasis (IC) is a leading cause of mycosis-associated mortality in the United States. We examined data from the National Center for Health Statistics and reviewed recent literature in order to update the epidemiology of IC...
  2. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  3. ncbi Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America
    Peter G Pappas
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 48:503-35. 2009
    Guidelines for the management of patients with invasive candidiasis and mucosal candidiasis were prepared by an Expert Panel of the Infectious Diseases Society of America...
  4. ncbi Growth of Candida albicans hyphae
    Peter E Sudbery
    Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, UK
    Nat Rev Microbiol 9:737-48. 2011
    ....
  5. pmc Candida albicans morphogenesis and host defence: discriminating invasion from colonization
    Neil A R Gow
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nat Rev Microbiol 10:112-22. 2012
    ..In this Review, we describe the properties of yeast cells and hyphae that are relevant to their interaction with the host, and the immunological mechanisms that differentially recognize colonizing versus invading C. albicans...
  6. pmc Candida albicans secreted aspartyl proteinases in virulence and pathogenesis
    Julian R Naglik
    Department of Oral Medicine, Pathology and Immunology, GKT Dental Institute, Kings College London, London, United Kingdom
    Microbiol Mol Biol Rev 67:400-28, table of contents. 2003
    ..We have critically discussed the data relevant to each of these seven criteria, with specific emphasis on how this proteinase family could contribute to Candida virulence and pathogenesis...
  7. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
    ..Analysis of such mutants revealed that virulence requires the glycolipid glucosylceramide. To our knowledge, this is the first C. albicans small molecule that has been found to be required specifically for virulence...
  8. ncbi Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment
    Michael A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med 125:S3-13. 2012
    ..This situation requires continuing attention. Rates of azole-resistant Aspergillus fumigatus are currently low, but there are reports of emerging resistance, including multi-azole resistant isolates in parts of Europe...
  9. ncbi An integrated model of the recognition of Candida albicans by the innate immune system
    Mihai G Netea
    Department of Medicine and Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Rev Microbiol 6:67-78. 2008
    ..In this Review, we use the fungal pathogen Candida albicans as a model for the complex interaction that exists between the host pattern-recognition systems and invading microbial pathogens...
  10. ncbi Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku Tokyo 108 8639, Japan
    Immunity 32:681-91. 2010
    ..Because IL-17A-deficient mice were highly susceptible to systemic candida infection, this study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation...
  11. ncbi Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry
    David L Horn
    Div of Infectious Diseases, Thomas Jefferson University, Ste 210, 211 S 9th St, Philadelphia, PA 19107, USA
    Clin Infect Dis 48:1695-703. 2009
    ..Candidemia remains a major cause of morbidity and mortality in the health care setting, and the epidemiology of Candida infection is changing...
  12. pmc Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality
    Matthew Morrell
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Antimicrob Agents Chemother 49:3640-5. 2005
    ..Alternatively, increased use of empiric antifungal treatment in selected patients at high risk for fungal bloodstream infection could also reduce delays in treatment...
  13. ncbi Importance of the Candida albicans cell wall during commensalism and infection
    Neil A R Gow
    School of Medical Sciences, Institute of Medical Sciences, Foresterhill University of Aberdeen, Aberdeen AB25 2ZD, UK
    Curr Opin Microbiol 15:406-12. 2012
    ....
  14. ncbi Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study
    Kevin W Garey
    Department of Clinical Science and Administration, University of Houston College of Pharmacy, Houston, TX, USA
    Clin Infect Dis 43:25-31. 2006
    ..The goals our analyses were to establish the frequency and duration of delayed antifungal treatment and to evaluate the relationship between treatment delay and mortality...
  15. pmc Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance
    J Chandra
    Center for Medical Mycology, University Hospitals of Cleveland, and Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Bacteriol 183:5385-94. 2001
    ..The studies described here form the basis for investigations into the molecular mechanisms of Candida biofilm biology and antifungal resistance and provide the means to design novel therapies for biofilm-based infections...
  16. ncbi Virulence factors of Candida albicans
    R A Calderone
    Dept of Microbiology and Immunology, Georgetown University Medical Center, 20007, Washington, DC, USA
    Trends Microbiol 9:327-35. 2001
    b>Candidiasis is a common infection of the skin, oral cavity and esophagus, gastrointestinal tract, vagina and vascular system of humans...
  17. pmc Interplay between Candida albicans and the mammalian innate host defense
    Shih Chin Cheng
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Infect Immun 80:1304-13. 2012
    ..albicans, ranging from how the host recognizes, responds, and clears C. albicans infection to how C. albicans evades, dampens, and escapes from host innate immunity...
  18. pmc Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
    Stephen P Saville
    Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Eukaryot Cell 2:1053-60. 2003
    ..This modified strain was then tested in an animal model of hematogenously disseminated candidiasis. Mice injected with this strain under conditions permitting hyphal development succumbed to the infection, ..
  19. pmc Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:1642-50. 2006
    ..mutants with a cell wall defective in mannosyl residues were less virulent in experimental disseminated candidiasis and elicited reduced cytokine production in vivo. We concluded that recognition of C...
  20. pmc Candida parapsilosis, an emerging fungal pathogen
    David Trofa
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Microbiol Rev 21:606-25. 2008
    ..parapsilosis virulence. The emerging information will provide a deeper understanding of C. parapsilosis pathogenesis and facilitate the development of new therapeutic approaches for treating C. parapsilosis infections...
  21. pmc Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    Rebecca S Shapiro
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Curr Biol 19:621-9. 2009
    ..This transition is normally regulated by environmental cues, such as exposure to serum, that are contingent upon elevated temperature to induce morphogenesis. The basis for this temperature dependence has remained enigmatic...
  22. pmc Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, USA
    PLoS Pathog 2:e63. 2006
    ..Known adhesins Als1 and Hwp1 also contribute to biofilm formation, as does the novel protein Ece1...
  23. pmc Candida infections of medical devices
    Erna M Kojic
    Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Microbiol Rev 17:255-67. 2004
    ..The medical and economic impact of these infections is enormous...
  24. pmc A Candida biofilm-induced pathway for matrix glucan delivery: implications for drug resistance
    Heather T Taff
    Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA
    PLoS Pathog 8:e1002848. 2012
    ..We propose that the discovery of inhibitors for these enzymes would provide promising anti-biofilm therapeutics...
  25. pmc Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, barcelona, Spain, from 2002 to 2003
    Benito Almirante
    Infectious Diseases Division, Hospital Universitari Vall d Hebron, Avda Vall d Hebron, 119 129, 08035 Barcelona, Spain
    J Clin Microbiol 43:1829-35. 2005
    ..Antifungal medication and catheter removal are critical in preventing mortality...
  26. pmc Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
    Cindy S Ma
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst 2010, Australia
    J Exp Med 205:1551-7. 2008
    ..Furthermore, they underscore the importance of Th17 responses in normal host defense against the common pathogens S. aureus and C. albicans...
  27. pmc Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, NY, USA
    Cell Microbiol 10:2180-96. 2008
    ..We have focused on Rim101 from Candida albicans, which we find to be required for virulence in an oropharyngeal candidiasis model...
  28. ncbi Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study
    A M Tortorano
    Istituto di Igiene e Medicina Preventiva, Universita degli Studi, IRCCS Ospedale Maggiore, Via F Sforza 35, 20122 Milan, Italy
    Eur J Clin Microbiol Infect Dis 23:317-22. 2004
    ..9%. The survey results underline the burden of candidaemia in a wide range of patient populations, confirm the importance of non- albicans species, and provide baseline data for future surveillance studies at a European level...
  29. pmc Recognition and blocking of innate immunity cells by Candida albicans chitin
    Hector M Mora-Montes
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Infect Immun 79:1961-70. 2011
    ..albicans cells but not with live cells. Therefore, chitin is normally not exposed to cells of the innate immune system but is capable of influencing immune recognition by blocking dectin-1-mediated engagement with fungal cell walls...
  30. ncbi High intrafamilial variability in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a case study
    D Capalbo
    Department of Pediatrics, Federico II University, Naples, Italy
    J Endocrinol Invest 35:77-81. 2012
    Autoimmune polyendocrinopathy- candidiasis-ectodermal-dystrophy syndrome (APECED) is a monogenic disease whose phenotype may reveal wide heterogeneity. The reasons of this variability still remain obscure.
  31. ncbi The glyoxylate cycle is required for fungal virulence
    M C Lorenz
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA
    Nature 412:83-6. 2001
    ..Neutropenic patients, deficient in these immune cells, are particularly susceptible to systemic candidiasis. Here we use genome-wide expression profiles of the related yeast Saccharomyces cerevisiae to obtain a ..
  32. ncbi Nosocomial fungal infections: epidemiology, diagnosis, and treatment
    Joshua Perlroth
    Division of Infectious Diseases, Harbor University of California Los Angeles UCLA Medical Center, California 90502, USA
    Med Mycol 45:321-46. 2007
    ..Nevertheless, the mortality of nosocomial fungal infections remains high, and new therapeutic and preventative strategies are needed...
  33. ncbi Candida biofilms and their role in infection
    L Julia Douglas
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Trends Microbiol 11:30-6. 2003
    ..Recent studies with mixed biofilms containing Candida and bacterial species suggest that extensive and striking interactions occur between the prokaryotic and eukaryotic cells in these adherent populations...
  34. ncbi Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae
    Marc Brennan
    Medical Mycology Unit, Department of Biology, National University of Ireland, Co Kildare, Maynooth, Ireland
    FEMS Immunol Med Microbiol 34:153-7. 2002
    ..The correlation with virulence measured in the mouse infection system suggests that Galleria may provide a convenient and inexpensive model for the in vivo screening of mutants of C. albicans...
  35. ncbi Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 172:3712-8. 2004
    ..The deleterious role of Treg cells on the innate immune response during disseminated candidiasis was underscored by the improved resistance to this infection after depletion of Treg cells. In conclusion, C...
  36. pmc Complementary adhesin function in C. albicans biofilm formation
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York 10032, USA
    Curr Biol 18:1017-24. 2008
    ..Here, we focus on an adherence mechanism that permits biofilm formation by Candida albicans, the major invasive fungal pathogen of humans...
  37. pmc Niche-specific regulation of central metabolic pathways in a fungal pathogen
    Caroline J Barelle
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Microbiol 8:961-71. 2006
    ....
  38. pmc Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans
    Saritha Suram
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 285:30676-85. 2010
    ..The results demonstrate that C. albicans engages both β-glucan and mannan-binding receptors on macrophages that act with MyD88 to regulate the activation of cPLA(2)α and eicosanoid production...
  39. pmc Identification and characterization of TUP1-regulated genes in Candida albicans
    B R Braun
    Department of Microbiology, University of California, San Francisco, California 94143 0414, USA
    Genetics 156:31-44. 2000
    ..TUP1 appears, therefore, to regulate many genes in C. albicans, a significant fraction of which are induced during filamentous growth, and some of which participate in pathogenesis...
  40. pmc Candida albicans scavenges host zinc via Pra1 during endothelial invasion
    Francesco Citiulo
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute HKI, Jena, Germany
    PLoS Pathog 8:e1002777. 2012
    ..Furthermore, functional similarities with phylogenetically unrelated prokaryotic systems indicate that syntenic zinc acquisition loci have been independently selected during evolution...
  41. ncbi Performance of Candida real-time polymerase chain reaction, β-D-glucan assay, and blood cultures in the diagnosis of invasive candidiasis
    M Hong Nguyen
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 54:1240-8. 2012
    The sensitivity of blood cultures for diagnosing invasive candidiasis (IC) is poor.
  42. pmc A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata
    Rupinder Kaur
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Hunterian 617, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 104:7628-33. 2007
    ..By monitoring the processing of a cell wall adhesin, Epa1, we also show that Yps proteases play an important role in cell wall re-modeling by removal and release of glycosylphosphatidylinositol-anchored cell wall proteins...
  43. ncbi Recognition of yeast nucleic acids triggers a host-protective type I interferon response
    Carmelo Biondo
    The Elie Metchnikoff Department, University of Messina, Messina, Italy
    Eur J Immunol 41:1969-79. 2011
    ..These data suggest that recognition of yeast nucleic acids by TLR7 and TLR9 triggers a host-protective IFN-α/β response...
  44. pmc Changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemia
    Jong Hee Shin
    Department of Laboratory Medicine, Chonnam National University Medical School, 8 Hakdong Dongku, Gwangju 501 757, South Korea
    J Clin Microbiol 45:2385-91. 2007
    ..glabrata from the same patient without antifungal therapy. In addition, we confirmed that C. glabrata could acquire azole resistance during the course of fungemia in association with azole therapy...
  45. pmc Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
    ..We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1...
  46. pmc Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice
    Lin Lin
    The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, California, USA
    PLoS Pathog 5:e1000703. 2009
    ..aureus and C. albicans from tissues. Thus, vaccine-mediated adaptive immunity can protect against both infections by targeting microbes for destruction by innate effectors...
  47. ncbi Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance
    Mohammed A Al-Fattani
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Med Microbiol 55:999-1008. 2006
    ....
  48. ncbi Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Infect Dis 193:1014-22. 2006
    ..We developed a model of candidiasis in Toll (Tl)-deficient Drosophila melanogaster. Similar to the situation in humans, C...
  49. ncbi Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Pediatrics 117:84-92. 2006
    Neonatal candidiasis is associated with substantial morbidity and mortality rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been reported.
  50. ncbi The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo
    Silvia Bellocchio
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 172:3059-69. 2004
    ..albicans and A. fumigatus require the coordinated action of distinct members of the IL-1R/TLR superfamily acting through MyD88 makes TLR manipulation amenable to the induction of host resistance to fungi...
  51. pmc Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation
    Jeniel E Nett
    University of Wisconsin, Department of Medicine, Madison, WI 53705, USA
    Eukaryot Cell 10:1660-9. 2011
    ..This novel connection helps explain how pathogens in a multicellular biofilm community are protected from anti-infective therapy...
  52. pmc Development and characterization of an in vivo central venous catheter Candida albicans biofilm model
    D Andes
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Infect Immun 72:6023-31. 2004
    ..albicans biofilm biology and drug resistance. In addition, the model provides a means to study novel drug therapies and device technologies targeted to the control of biofilm-associated infections...
  53. pmc Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo
    Keunsook K Lee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Antimicrob Agents Chemother 56:208-17. 2012
    ..Our results suggest that the efficacy of caspofungin against C. albicans was reduced in vivo due to either elevation of chitin levels in the cell wall or acquisition of FKS1 point mutations...
  54. ncbi A high-affinity iron permease essential for Candida albicans virulence
    N Ramanan
    Microbial Collection and Screening Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Science 288:1062-4. 2000
    ..Thus, CaFTR1-mediated iron-uptake mechanism constitutes a virulence factor of Candida albicans and may be a target for the development of anti-Candida therapies...
  55. pmc Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program
    Rana A Hajjeh
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 42:1519-27. 2004
    ..7% of isolates, and > or = 2 microg/ml for 0.4% of isolates. Our findings highlight changes in the epidemiology of Candida BSI in the 1990s and provide a basis upon which to conduct further studies of selected high-risk subpopulations...
  56. pmc Live imaging of disseminated candidiasis in zebrafish reveals role of phagocyte oxidase in limiting filamentous growth
    Kimberly M Brothers
    Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA
    Eukaryot Cell 10:932-44. 2011
    ..infection model results in a lethal disseminated disease that shares important traits with disseminated candidiasis in mammals, including dimorphic fungal growth, dependence on hyphal growth for virulence, and dependence on the ..
  57. pmc Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans
    Christopher Askew
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000612. 2009
    ..albicans and Gal4p provides a carbon source-dependent fine-tuning of gene expression while regulating the metabolic flux between respiration and fermentation pathways...
  58. pmc The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
    Shih Chin Cheng
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Leukoc Biol 90:357-66. 2011
    ..These results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans...
  59. pmc Host cell invasion and virulence mediated by Candida albicans Ssa1
    Jianing N Sun
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, New York, United States of America
    PLoS Pathog 6:e1001181. 2010
    ..A C. albicans ssa1Δ/Δ mutant had attenuated virulence in murine models of disseminated and oropharyngeal candidiasis, whereas an ssa2Δ/Δ mutant did not...
  60. ncbi CRZ1, a target of the calcineurin pathway in Candida albicans
    Mahir Karababa
    Institute of Microbiology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
    Mol Microbiol 59:1429-51. 2006
    ..Even though this work establishes CRZ1 as a calcineurin target, further studies are needed to identify other calcineurin-dependent elements in C. albicans...
  61. ncbi Mice with disseminated candidiasis die of progressive sepsis
    Brad Spellberg
    Los Angeles Biomedical Research Institute, Division of Infectious Diseases at Harbor University of California at Los Angeles Medical Center, Torrance 90502, USA
    J Infect Dis 192:336-43. 2005
    ..The murine model of hematogenously disseminated candidiasis is the standard for investigating both the activity of antifungal agents and the pathogenesis of this disease...
  62. pmc Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence
    Patricia L Carlisle
    Department of Microbiology and Immunology, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7758, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 106:599-604. 2009
    ..UME6 expression significantly increases hyphal formation and promotes virulence in a mouse model of systemic candidiasis. Our results strongly suggest that shifting the morphology of a C...
  63. pmc Mucosal damage and neutropenia are required for Candida albicans dissemination
    Andrew Y Koh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 4:e35. 2008
    ..albicans disease as well as identifying virulence factors that are necessary for fungal GI colonization and dissemination. The model may also prove valuable for evaluating therapies to control C. albicans infections...
  64. ncbi Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions
    Antje Albrecht
    Robert Koch Institut, Berlin, Germany
    J Biol Chem 281:688-94. 2006
    ..albicans to epithelial cells and caused attenuated epithelial cell damage during experimental oral infection suggesting a unique role for these proteases in both cellular processes and host-pathogen interactions...
  65. pmc Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Clin Microbiol Rev 12:80-96. 1999
    ..glabrata infections with comparisons to C. albicans as a means of contrasting the two species commonly observed and emphasizing the many recognized differences...
  66. pmc Candida orthopsilosis and Candida metapsilosis spp. nov. to replace Candida parapsilosis groups II and III
    Arianna Tavanti
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    J Clin Microbiol 43:284-92. 2005
    ..parapsilosis and relatively high levels of sequence variability among isolates of C. orthopsilosis suggest that the former species may have evolved very recently from the latter...
  67. pmc Dispersion as an important step in the Candida albicans biofilm developmental cycle
    Priya Uppuluri
    Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, United States of America
    PLoS Pathog 6:e1000828. 2010
    ..associated with candidemia and establishment of disseminated invasive disease, two of the gravest forms of candidiasis. Using a simple flow biofilm model recently developed by our group, we have performed initial investigations ..
  68. pmc Epidemiology of candidemia in Brazil: a nationwide sentinel surveillance of candidemia in eleven medical centers
    Arnaldo L Colombo
    Division of Infectious Diseases, Universidade Federal de Sao Paulo, Rua Botucatu 740, 04023 062 Sao Paulo, Brazil
    J Clin Microbiol 44:2816-23. 2006
    ..Antifungal resistance was rare, but correlation between fluconazole and voriconazole MICs suggests cross-resistance may occur...
  69. ncbi Nicotinic acid limitation regulates silencing of Candida adhesins during UTI
    Renee Domergue
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 308:866-70. 2005
    ..The adaptation of C. glabrata to the host, therefore, involves a loss of metabolic capacity and exploitation of the resulting auxotrophy to signal a particular host environment...
  70. pmc Dectin-1 is required for beta-glucan recognition and control of fungal infection
    Philip R Taylor
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX13RE, UK
    Nat Immunol 8:31-8. 2007
    ..Our results establish a fundamental function for beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses...
  71. pmc Resistance to echinocandin-class antifungal drugs
    David S Perlin
    Public Health Research Institute, New Jersey Medical School UMDNJ, Newark, NJ, USA
    Drug Resist Updat 10:121-30. 2007
    ..and can account for intrinsic reduced susceptibility of certain species. Fks1 mutations confer resistance in both yeasts and moulds suggesting that this mechanism is pervasive in the fungal kingdom...
  72. pmc Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection
    Matthew J Robinson
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, England, UK
    J Exp Med 206:2037-51. 2009
    ..Thus, Dectin-2 constitutes a major fungal PRR that can couple to the Syk-CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection...
  73. pmc Protective role of naturally occurring interleukin-17A-producing γδ T cells in the lung at the early stage of systemic candidiasis in mice
    Takashi Dejima
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Infect Immun 79:4503-10. 2011
    ..Thus, our study demonstrated a novel role of naturally occurring IL-17A-producing γδ T cells in the first line of host defense against C. albicans infection...
  74. ncbi The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation
    Katja Seider
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, 07745 Jena, Germany
    J Immunol 187:3072-86. 2011
    ..Our results suggest persistence of C. glabrata within macrophages as a possible immune evasion strategy...
  75. ncbi Candida albicans dimorphism as a therapeutic target
    Ilse D Jacobsen
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute Jena, Beutenbergstraße 11a, D 07745, Jena, Germany
    Expert Rev Anti Infect Ther 10:85-93. 2012
    ..In this review, we will provide an overview of the known and potential roles of C. albicans dimorphism and will discuss the potential benefit of drugs that can inhibit the morphological transition...
  76. ncbi Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, Athens, Marousi, 15123, Greece
    Eur J Clin Microbiol Infect Dis 25:419-25. 2006
    ....
  77. pmc Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans
    Rana Pratap Singh
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    J Biol Chem 286:25154-70. 2011
    ..Together our data indicates that the Cap2-HAP complex functions both as a positive and a negative regulator to maintain iron homeostasis in C. albicans...
  78. pmc Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 8:e1002865. 2012
    Invasive candidiasis is the 4(th) leading cause of nosocomial bloodstream infection in the US with mortality that exceeds 40% despite administration of antifungal therapy; neutropenia is a major risk factor for poor outcome after ..
  79. pmc Regulation of innate immune response to Candida albicans infections by αMβ2-Pra1p interaction
    Dmitry A Soloviev
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Infect Immun 79:1546-58. 2011
    ..Using α(M)β₂-KO mice and mutated strains of C. albicans in two models of murine candidiasis, we demonstrate that neutrophils derived from mice deficient in α(M)β₂ have a reduced ability to kill C...
  80. pmc The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion
    Petra Heymann
    Institut fur Mikrobiologie, Heinrich Heine Universitat Dusseldorf, Germany
    Infect Immun 70:5246-55. 2002
    ..albicans infection, namely epithelial invasion and penetration, while in the blood or within organs other sources of iron, including heme, may be used...
  81. pmc Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis
    Lisa Y Ngo
    Vaccine and Infectious Diseases Division
    J Infect Dis 209:109-19. 2014
    ..During murine systemic candidiasis, interruption of CCR2-dependent inflammatory monocyte trafficking into infected kidneys impaired fungal ..
  82. ncbi Protein glycosylation in Candida
    Hector M Mora-Montes
    Institute of Medical Sciences, University of Aberdeen, UK
    Future Microbiol 4:1167-83. 2009
    b>Candidiasis is a significant cause of invasive human mycosis with associated mortality rates that are equivalent to, or worse than, those cited for most cases of bacterial septicemia...
  83. pmc Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis
    Agostinho Carvalho
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Cell Mol Immunol 9:276-86. 2012
    ..Dectin-1 was required for the proper control of gastrointestinal and vaginal candidiasis in C57BL/6, but not BALB/c mice; in fact, the latter showed increased resistance in the absence of dectin-1...
  84. ncbi Host defence against disseminated Candida albicans infection and implications for antifungal immunotherapy
    Alieke G Vonk
    Radboud University Nijmegen Medical Center, Department of Medicine 463, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Expert Opin Biol Ther 6:891-903. 2006
    ..Protective immunity to disseminated candidiasis, the manifestation of C...
  85. pmc Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing
    Tracy Nevitt
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Pathog 7:e1001322. 2011
    ..These studies suggest that host iron status is a modifier of infectious disease that modulates the dependence on distinct mechanisms of microbial Fe acquisition...
  86. ncbi Game theoretical modelling of survival strategies of Candida albicans inside macrophages
    S Hummert
    Friedrich Schiller University, School of Biology and Pharmaceutics, Ernst Abbe Platz 2, D 07743 Jena, Germany
    J Theor Biol 264:312-8. 2010
    ..Our results are in agreement with wet-lab results presented by other groups and the model parameters can be estimated from experimental data...
  87. ncbi Species distribution and antifungal susceptibility of Candida bloodstream isolates in Kuwait: a 10-year study
    Eiman M Mokaddas
    Department of Microbiology, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait 13110
    J Med Microbiol 56:255-9. 2007
    ..glabrata and C. krusei were susceptible to voriconazole, including those resistant to fluconazole. Although amphotericin B and fluconazole are widely used in clinical practice in Kuwait, resistance to these drugs remained low...
  88. ncbi Candidosis in the intensive care unit: a 20-year survey
    A M Tortorano
    Istituto di Igiene e Medicina Preventiva, Università degli Studi IRCCS Ospedale Maggiore, Milano, Italy
    J Hosp Infect 57:8-13. 2004
    ..33/1000 patient days). The low rate of ICU-acquired candidaemia despite the inclusion of severely compromised patients in this study confirms the usefulness of routine mycological surveillance in preventing deep-seated candidosis...
  89. pmc Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections
    Ilse D Jacobsen
    Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    PLoS ONE 6:e19741. 2011
    ..Despite its limitations, it presents a useful alternative tool to pre-screen C. albicans strains to select strains for subsequent testing in murine models...
  90. ncbi Candida albicans Cas5, a regulator of cell wall integrity, is required for virulence in murine and toll mutant fly models
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Infect Dis 200:152-7. 2009
    ..tigr.org/tigr-scripts/e2k1/qzhao/page.cgi?num=1 ) by means of a previously established model of invasive candidiasis in Toll mutant flies. C...
  91. pmc Vaccine and monoclonal antibody that enhance mouse resistance to candidiasis
    Hong Xin
    Department of Pediatrics, Louisiana State University Health Sciences Center and Research Institute for Children, Children s Hospital, New Orleans, Louisiana 70118, USA
    Clin Vaccine Immunol 18:1656-67. 2011
    ..1,2-mannotriose [β-(Man)(3)] on the cell surface of Candida albicans protect mice against disseminated candidiasis (H. Xin, S. Dziadek, D. R. Bundle, and J. E. Cutler, Proc. Natl. Acad. Sci. U. S. A. 105:13526-13531, 2008)...
  92. ncbi The ALS gene family of Candida albicans
    L L Hoyer
    Dept of Veterinary Pathobiology, University of Illinois at Urbana Champaign, 61802, USA
    Trends Microbiol 9:176-80. 2001
    ..The ALS genes are one example of a gene family associated with pathogenicity mechanisms in C. albicans and other Candida species...
  93. pmc UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence
    Mohua Banerjee
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Mol Biol Cell 19:1354-65. 2008
    ..both in vitro and during infection in vivo and is attenuated for virulence in a mouse model of systemic candidiasis. We also show that UME6 is an important downstream component of both the RFG1-TUP1 and NRG1-TUP1 filamentous ..
  94. ncbi Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria
    M A Pfaller
    University of Iowa, Iowa City, United States
    Drug Resist Updat 14:164-76. 2011
    ..We applied these findings to propose new species-specific CBPs for echinocandins and Candida. Of 18 candidiasis cases refractory to echinocandins and with fks mutations, 28% (CSF), 58% (ANF) and 66% (MCF) had MICs in the S ..
  95. pmc In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis
    Patricia M Tavares
    Laboratorio de Estudos Integrados em Bioquimica Microbiana, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CCS, Bloco I, Ilha do Fundao, Rio de Janeiro, RJ 21941590, Brazil
    Antimicrob Agents Chemother 52:4522-5. 2008
    ..Moreover, glucosylceramide levels in Candida species correlate with RsAFP2 sensitivity. We found RsAFP2 prophylactically effective against murine candidiasis.
  96. ncbi The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence
    Mary T Kelly
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Microbiol 53:969-83. 2004
    ..The CaAce2 protein is localized to the daughter nucleus of large budded cells at the end of mitosis. C. albicans Ace2p therefore plays a major role in morphogenesis and adherence and resembles S. cerevisiae Ace2p in function...
  97. ncbi Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood
    Chantal Fradin
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Mol Microbiol 56:397-415. 2005
    ..However, C. albicans is equipped with several genes and transcriptional programmes, which may help the fungus to counteract the attack of neutrophils, to escape from the bloodstream and to cause systemic infections...
  98. pmc Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence
    Bethann S Hromatka
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:4814-26. 2005
    ..In a mouse model of disseminated candidiasis, a YHB1 deleted C...
  99. ncbi How human pathogenic fungi sense and adapt to pH: the link to virulence
    Dana A Davis
    1360 Mayo Building MMC196, Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    Curr Opin Microbiol 12:365-70. 2009
    ..Here, several recent advances into Rim101-dependent functions implicated in disease progression are discussed...
  100. ncbi Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes
    A L Mavor
    Robert Koch Institut, Berlin, Germany
    Curr Drug Targets 6:863-74. 2005
    ..Most studies have focussed on C. albicans and this review will therefore summarise work on the various known virulence factors and methods used to identify further virulence attributes of this fungus...
  101. pmc Candida biofilms: an update
    Gordon Ramage
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, United Kingdom
    Eukaryot Cell 4:633-8. 2005

Research Grants79

  1. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
    ..HIV disease/AIDS, ranging from mild clinical manifestations such as oral thrush to a more serious disseminated candidiasis. Emerging drug resistance is a major problem in Candida, contributed by enzymes involved in the detoxification ..
  2. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..albicans is a widespread human fungal pathogen that causes high rates of mortality during systemic infections (candidiasis)...
  3. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
    b>Candidiasis, the most prevalent fungal disease, affects millions annually in the U.S. alone. Patients with cancer, AIDS and diabetes, as well as premature infants and individuals requiring intensive care, are among those at risk...
  4. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..one or more fungal infections at some time during their illness, the most frequent one being oropharyngeal candidiasis (1)...
  5. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
    ..albicans) infection. C. albicans is the most common cause of systemic candidiasis, an infection that occurs frequently in immune compromised individuals (i.e...
  6. Role of phosphatidylethanolamine in regulating virulence in Candida albicans
    SARAH ELIZABETH DAVIS; Fiscal Year: 2013
    ..fungal pathogens of humans, and Candida albicans, in particular, is the most common cause of oropharyngeal candidiasis, which is an infection that affects patients suffering from Acquired Immune Deficiency Syndrome (AIDS) among ..
  7. AIDS Opportunistic Infections: Virulence of C. glabrata
    Brendan Cormack; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The HIV-positive population is at increased risk for mucosal candidiasis and, in late stage AIDS, for disseminated candidiasis...
  8. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..For example, these chemokines may play major roles in diseases such as periodontal disease, or vaginal candidiasis. Finally, we have observed that one of these chemokines, CXCL14, is specifically expressed in taste buds but ..
  9. Novel Antifungal Therapeutic Approaches
    Joseph Heitman; Fiscal Year: 2012
    ..Finally, drugs, analogs, and combinations will be tested in animal models of cryptococcosis and candidiasis. Our assembled team of collaborators in natural products, medicinal chemistry, enzymology, structural biology, ..
  10. Identification of broad-spectrum antifungal efflux pump inhibitors
    Richard Cannon; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Fungal infections, exemplified by oral and invasive candidiasis, cause considerable morbidity and mortality in an ever-increasing human population: the immunocompromised...
  11. Impact of regulatory T cells on human peripheral B cell tolerance
    Eric Meffre; Fiscal Year: 2013
    ..immune deficiency, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients, who display a defective Treg cell compartment and suffer from ..
  12. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2012
    ..significance of these interactions will be assessed in PMN killing assays and in vivo murine models of systemic candidiasis utilizing C...
  13. Extracellular pH modulation by Candida albicans in vitro and in vivo
    Michael C Lorenz; Fiscal Year: 2013
    ..Others have shown that stp2? mutants are attenuated in a fly model of candidiasis;two other non-alkalinizing mutant, csh3?, encoding an ER chaperone for amino acid permeases, and dur1,2?, ..
  14. IL-17-Induced Regulation of C/EBPbeta
    MICHELLE ROSAN SIMPSON-ABELSON; Fiscal Year: 2012
    ..with IL-17 receptor deficiencies or with antibodies against IL-17 are highly prone to oral and mucocutaneous candidiasis. However, the specific signaling pathways used by IL-17 and its receptor to accomplish immunity to fungi are ..
  15. Nlrp3 inflammasome signaling in immune responses to Candida albicans
    Fayyaz S Sutterwala; Fiscal Year: 2013
    ..cause severe opportunistic infections particularly in immunocompromised patients ranging from mucocutaneous candidiasis to bloodstream infections...
  16. Candida albicans Epithelial Cell Interactions and Oropharyngeal Disease
    Scott G Filler; Fiscal Year: 2013
    ..Azole antifungal agents are the current mainstay of therapy for oropharyngeal candidiasis. However, because of the emergence of azole resistance, it is critical to develop novel strategies to prevent ..
  17. AIDS Opportunistic Infections: Virulence of C. glabrata
    Brendan Cormack; Fiscal Year: 2009
    The HIV-positive population is at increased risk for mucosal candidiasis and, in late stage AIDS, for disseminated candidiasis...
  18. Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental Outcomes
    Daniel K Benjamin; Fiscal Year: 2012
    ..of infection-related death or neurodevelopmental impairment in neonates with birthweight <750 g is invasive candidiasis. Invasive candidiasis is diagnosed by positive culture for Candida sp. from normally sterile body fluid...
  19. NEONATAL CANDIDIASIS &IMMUNE COMPROMISE DURING DEVELOPMENT
    JOSEPH MARK BLISS; Fiscal Year: 2011
    ..organism by constructing mutants for these genes and examining their phenotype in a murine neonatal model of candidiasis. Specific Aim 2 will express these antibody fragments in the context of bonafide human IgG and test these ..
  20. Virulence factor identification by comparative transcriptomics in Candida species
    Michael C Lorenz; Fiscal Year: 2013
    ..This poses a significant clinical challenge as disseminated candidiasis is difficult to diagnose and is often refractory to antifungal therapy, leading to a mortality rate that has ..
  21. Analysis of Candida albicans filamentation using SILAC
    DEREK PAUL THOMAS; Fiscal Year: 2012
    ..albicans, is the host. Candidiasis now represents the third most frequent nosocomial infection in hospitals both in the US and worldwide and C...
  22. Genetics of susceptibility to candidiasis
    Scott Filler; Fiscal Year: 2009
    ..Candida albicans causes both mucosal and disseminated disease. Oropharyngeal candidiasis (OPC) results in significant morbidity in many patients, especially those with HIV/AIDS...
  23. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..We hypothesize that ATAK cells are effective at treating disseminated candidiasis because they circulate to infected tissues and there kill fungi by oxidative and/or non-oxidative mechanisms...
  24. Innate Immune Recognition of Candida albicans Infection in a C. elegans Model
    Read Pukkila-Worley; Fiscal Year: 2013
    ..I was the first to show that C. elegans can be used to accurately model key aspects of human candidiasis. I also found that the nematode mounts a targeted antifungal response in a genome-wide transcription profiling ..
  25. 11th ASM Conference on Candida and candidiasis
    Scott G Filler; Fiscal Year: 2012
    DESCRIPTION: Candida is the major fungal pathogen of humans, causing diseases that range from oral and vaginal candidiasis to life-threatening candidemia and invasive disease...
  26. Synthetic glycopeptide vaccines that enhance resistance to candidiasis
    Hong Xin; Fiscal Year: 2013
    ..For example, hematogenously disseminated candidiasis is a life-threatening disease and remains the third most common bloodstream infection in hospitalized patients ..
  27. Small molecule inhibitors of a Candida albicans histone modifying enzyme
    JESSICA RAMOS LOPES DA ROSA-SPIEGLER; Fiscal Year: 2012
    ..display increased sensitivity to macrophages in vitro and whether they are pathogenic in the established murine candidiasis model...
  28. Role of Langerhans Cells in the Cutaneous Immune System
    Daniel H Kaplan; Fiscal Year: 2013
    ..Finally, we will generate an antigen-specific infection model by combining an existing model of cutaneous Candidiasis with Candida albicans that we will engineer to express ovalbumin...
  29. Genome Integrity in Candida albicans
    Judith G Berman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oropharyngeal candidiasis is often the earliest detectable clinical manifestation of infection with Human Immunodeficiency Virus (HIV) and the most prevalent opportunistic infection observed in ..
  30. Development of Monoclonal Antibody (Mab) Biologics against Neonatal Candidiasis
    Jose L Lopez-Ribot; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Candidiasis represents the most common fungal infection in hospitalized patients and Candida albicans remains the main etiologic agent of candidiasis, as this otherwise normal commensal of humans is ..
  31. Identification of calcineurin-binding proteins in A. fumigatus septum formation
    William J Steinbach; Fiscal Year: 2013
    ..by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus has surpassed invasive candidiasis as the most frequent fungal cause of death in immunocompromised patients...
  32. Phenotypic Plasticity and Inter-Species Communication in Candida Albicans
    STEPHEN KNOX JONES; Fiscal Year: 2013
    ..90% of HIV-infected individuals develop oropharyngeal candidiasis (OPC), and oral Candida infections also affect 5% of newborns and 10% of elderly patients (2;3)...
  33. Vaccine Strategies for Candidal Infections
    John P Hennessey; Fiscal Year: 2010
    ..Even with modern antifungal therapy, disseminated candidiasis has an unacceptable attributable mortality of 40%- 50%...
  34. Co-Delivery of Antifungal Agents: Toxicity and Efficacy in Invasive Candidiasis
    Glen S Kwon; Fiscal Year: 2013
    ..for the treatment of systemic fungal diseases, morbidity and mortality are substantial;noting that invasive candidiasis (IC) is the fourth most common cause of nosocomial bloodstream infection in the United States chiefly among ..
  35. REGULATION OF FILAMENTOUS GROWTH IN YEAST
    Haoping Liu; Fiscal Year: 2013
    ..albicans pathways for the promoter recruitment of Hda1 and its importance in invasive candidiasis. Aim 3 studies functions and regulation of Cph2...
  36. Synthetic Genetic Analysis of the RAM network in C. albicans
    Anuj Kumar; Fiscal Year: 2010
    ..Nearly all HIV/AIDS patients will develop oropharyngeal (OPC) or esophageal candidiasis during their lifetime...
  37. CANDIDACIDAL MECHANISMS OF SALIVARY HISTATINS
    Mira Edgerton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oropharyngeal candidiasis, or thrush, is a frequent disease among immunocompromised patients as well as in elderly people and young children...
  38. Phenotypic Switching in Candida albicans and its Role in Pathogenesis
    RICHARD JOHN BENNETT; Fiscal Year: 2010
    ..are particularly susceptible to Candida infections, with 90% of this population experiencing oropharyngeal candidiasis at some stage of the disease. C...
  39. Candida-Bacteria Communication in Oral Biofilms
    Richard J Lamont; Fiscal Year: 2013
    ..albicans, leading to disease conditions such as denture-induced stomatitis, oral candidiasis, periodontitis, and root canal infections...
  40. THERAPY AGAINST RECALCITRANT C. albicans INFECTION
    Thomas A Dahl; Fiscal Year: 2012
    ..We plan to target currently untreatable diseases: Recurrent Vulvovaginal Candidiasis (RVC), refractory Oropharyngeal Candidiasis (OPC) and biofilm infection of central venous catheters with a ..
  41. Environmental Conditions Control Filamentation and Virulence in Candida albicans
    DELMA CHILDERS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Candida albicans is the leading cause of oral candidiasis worldwide...
  42. Centromere structure and isochromosome formation in Candida albicans
    Laura S Burrack; Fiscal Year: 2010
    Candida albicans is the most prevalent human fungal pathogen and is capable of causing invasive candidiasis, a severe disease with high mortality rates and medical costs...
  43. Secreted Virulence Proteins and biofilm formation in Candida
    SAMUEL AUSTIN LEE; Fiscal Year: 2013
    ..decades ago, and diagnostically, the traditional blood culture has only a 50% sensitivity to detect invasive candidiasis. Thus, our ability to prevent, diagnose, and treat Candida infections is still in need of great improvement...
  44. Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network
    Ronald Goldberg; Fiscal Year: 2013
    ..Medical Mycology, Biomedical Engineering, and Genetic Epidemiology, namely, Early Diagnosis of Neonatal Candidiasis and the NICHD NRN Anonymized DNA Bank...
  45. Salivary Gland IL-17R Signaling in Oral Candidiasis
    HEATHER RAQUEL CONTI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Oropharyngeal candidiasis (OPC) is an opportunistic infection caused by the commensal fungus Candida albicans (C. albicans)...
  46. Cell Wall Biogenesis in Candida albicans
    Stephen J Free; Fiscal Year: 2013
    ..albicans will highlight the possibility o targeting these enzymes for the development of an antifungal agent to treat invasive Candidiasis and other invasive fungal infections.
  47. Optimized CYP51 Inhibitors for the Oral Treatment of CNS Coccidioides Infections
    Edward P Garvey; Fiscal Year: 2013
    ..It is currently in Phase I clinical studies in the U.S. prior to development as a treatment fr either invasive candidiasis or oncychomycosis...
  48. Protective Human Anti-Candida Antibodies
    Mason X Zhang; Fiscal Year: 2013
    ..Candida albicans is a yeast-like fungal pathogen and can cause life-threatening hematogenously disseminated candidiasis. The cell surface of C...
  49. Sex and Disease: The Candida albicans Mating Cycle and Candidiasis
    Kevin Alby; Fiscal Year: 2010
    ..Over 50% of healthy patients carry Candida in their mouths while oropharyngeal candidiasis occurs in upwards of 90% of HIV+ individuals progressing to AIDS...
  50. Role of Ppg1 phosphatase in controlling Candida albicans morphology and virulence
    MOHAMMAD ALBATAINEH; Fiscal Year: 2013
    ..provided by applicant): Candida albicans, the major human fungal pathogen, is the leading cause of oral candidiasis worldwide and fourth leading cause of hospital-acquired bloodstream infections in the U.S...
  51. Mode of action of the salivary antimicrobial peptide histatin-5
    ALBERT MOCHON; Fiscal Year: 2009
    ..under immunocompromising conditions, this benign microbe can become an opportunistic pathogen causing oral candidiasis (i.e. thrush)...
  52. CANDIDA GENE EXPRESSION DURING OROPHARYNGEAL INFECTION
    Aaron P Mitchell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oropharyngeal candidiasis (OPC) is among the first clinical manifestations of AIDS...
  53. In vivo profiling for oral candidiasis drug target discovery
    David A Schofield; Fiscal Year: 2010
    ..albicans genes induced during murine oral candidiasis. Specifically, we identified a subset of: (i) in vivo expressed genes;(ii) infection and colonization-..
  54. Multi-center studies to improve diagnosis and treatment of pediatric candidiasis
    Theoklis Zaoutis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive candidiasis is a common and frequently fatal infection in high-risk hospitalized children...
  55. Gut colonization by C. albicans: interactions with the host and its microbiota
    VICTORIA BROWN KENNERLY; Fiscal Year: 2009
    ..AIM 3: assess the role of glucose sensing in virulence with a mouse model of disseminated Candidiasis. Long-term goals are to establish a model for C...
  56. Dynamics of mixed candida species biofilms in response to antifungal treatment
    Geethanjali Vipulanandan; Fiscal Year: 2013
    ..These biofilms are associated with the opportunistic yeast infection, oral candidiasis (oral thrush), found in newborns and many patients with AIDS, diabetes and cancer. Even though C...
  57. Parasexual Reproduction and Biofilm Formation in Candida albicans
    RICHARD JOHN BENNETT; Fiscal Year: 2010
    ..are particularly susceptible to Candida infections, with 90% of this population experiencing oropharyngeal candidiasis at some stage of the disease. C...
  58. Molecular, immunological, and clinical dissection of STAT1 hypermorphic mutations
    Steven M Holland; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent disease of the nails, skin, oral and genital mucosae...
  59. 10th ASM Conference on Candida and candidiasis
    Judith G Berman; Fiscal Year: 2010
    ..Candida is the major fungal pathogen of humans, causing infections that range from oral and vaginal candidiasis to life-threatening candidemia and invasive disease...
  60. Large scale synthetic genetic analysis in Candida albicans
    Damian J Krysan; Fiscal Year: 2013
    ..Indeed, nearly all HIV-infected individuals will develop either oral pharyngeal (OPC) or esophageal candidiasis (EC) at some point in their lives. The ability of C...
  61. Bcr1p as a candida neutrophil resistance regulator
    Yue Fu; Fiscal Year: 2010
    ..Phagocytes are the central effectors in host defense against hematogenously disseminated candidiasis. Using a new function-based approach, we have successfully identified a Candida albicans putative gene, HYR1, ..
  62. Targeting virulence against oral candidiasis in HIV/AIDS
    Jose L Lopez-Ribot; Fiscal Year: 2013
    ..already from the very early reports, one of the AIDS-defining opportunistic infections was oropharyngeal candidiasis (OPC) or thrush...
  63. Novel Rinse to Treat Oral Candidiasis in Cancer Patients
    Bakul Bhatt; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Oral candidiasis (oropharyngeal candidosis or thrush) is a common infection in immunosuppressed individuals, and, if not blunted, can transit to esophageal candidosis or life-threatening ..
  64. Creation and validation of a lux-positive Candida strain
    Yue Fu; Fiscal Year: 2007
    ..An estimated 60-70,000 cases of disseminated candidiasis occur per year in the US alone...
  65. Immunity to Oral Candidiasis
    SARAH GAFFEN; Fiscal Year: 2009
    ..Oropharyngeal candidiasis (OPC), caused by the yeast Candida albicans, is a major disease associated with immunosuppression due to ..
  66. Candida albicans oral biofilm
    WELDA CHAFFIN; Fiscal Year: 2004
    ..Oral candidiasis is associated with derangements of the oral flora related with the acquisition of microbes by neonates and anti-..
  67. Development of immune assays for HPV-32
    Michael Hagensee; Fiscal Year: 2006
    ..Opportunistic infections of the oral cavity afflict 50% of all HIV infected patients, and include oropharyngeal candidiasis (OPC), oral hairy leukoplakia (OHL) and oral warts caused by the mucosatropic human papillomavirus (HPV)...
  68. Antifungal Denture Adhesive Film for Oral Candidiasis
    THOMAS GERDING; Fiscal Year: 2004
    ..ADA) System that will minimize or eliminate the current shortcomings of oral mucosal treatment modalities for candidiasis in denture patients. A recent study reported that over 75 percent of complete denture wearers exhibit dense C...
  69. P-113: a novel peptide therapy for vaginal candidiasis
    David Osborne; Fiscal Year: 2005
    Vaginal candidiasis (VC) is a fungal infection affecting approximately 75% of women at least once during their lifetimes and results in more than 40 million cases per year in the US...
  70. VAGINAL DOUCHING AS A RISK FACTOR FOR VAGINITIS
    Maureen Hatch; Fiscal Year: 2001
    ..Vaginitis also facilitates HIV transmission. Bacterial vaginosis and candidiasis are the most common causes of vaginitis...
  71. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..which the rAls3p-N vaccine protects against disseminated candidiasis is b that mice deficient in IL-17A are not protected by the vaccine...
  72. New methods for the early diagnosis of invasive fungal infections
    Maurizio Del Poeta; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Invasive fungal infections, such as cryptococcosis, candidiasis and aspergillosis, have dramatically emerged in the last two decades and are associated with very poor prognosis...
  73. AIDS Opportunistic Pathogens/Fungal Cell Wall Drug Targets
    Brendan Cormack; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Oral candidiasis is a hallmark of HIV infection. A third of HIV sero-positive and 90% of AIDS patients will present with oropharyngeal candidiasis...
  74. HISTIDINE-RICH POLYPEPTIDES, ORAL CANDIDIASIS AND AIDS
    JERRY POLLOCK; Fiscal Year: 1992
    ..In HIV infected individuals, acquisition of oral candidiasis has become an early indicator of the development of opportunistic infections and AIDS...
  75. SALIVA AND ANTICANDIDAL DEFENSE MECHANISMS IN HIV/AIDS
    Chih ko Yeh; Fiscal Year: 2000
    ..with the progression of HIV infection and that such alterations in salivary gland function predispose to oral candidiasis. Secondly, with increasing severity of HIV infection, patients develop Sjogren's Syndrome-like features...
  76. Prevention of Candidiasis in Critically III Patients
    SHELLEY MAGILL; Fiscal Year: 2007
    ..to become an independent investigator in patient-oriented research, with expertise in the area of Candida and candidiasis in compromised patient populations...
  77. Colorimetric Substrates of SAP2 for Vaginal Candidiasis
    Stephen Johnson; Fiscal Year: 2004
    ..and rapid in vitro diagnostic (IVD) test for the evaluation of patient vaginal fluid specimens for vulvovaginal candidiasis using secreted aspartyl proteinase (SAP) as a biomarker...
  78. Photodynamic therapy of oral candidiasis
    CONSTANTINE HAIDARIS; Fiscal Year: 2005
    ..Oropharyngeal candidiasis (OPC) results from fungal overgrowth and penetration of oral epithelium when the body's physical and ..
  79. Non-Toxic Gel to Treat Vulvovaginal Candidiasis
    Charles Gauntt; Fiscal Year: 2006
    ..by applicant): The goal of this project is to develop a safe biocidal vaginal gel for treatment of vulvovaginal candidiasis (WC)...