aspergillosis

Summary

Summary: Infections with fungi of the genus ASPERGILLUS.

Top Publications

  1. ncbi Aspergillosis case-fatality rate: systematic review of the literature
    S J Lin
    Department of Pharmacy Administration, University of Illinois at Chicago, Chicago, IL, USA
    Clin Infect Dis 32:358-66. 2001
  2. pmc Aspergillus fumigatus and aspergillosis
    J P Latge
    Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris, France
    Clin Microbiol Rev 12:310-50. 1999
  3. doi Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America
    Thomas J Walsh
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Infect Dis 46:327-60. 2008
  4. pmc Sub-telomere directed gene expression during initiation of invasive aspergillosis
    Andrew McDonagh
    Department of Microbiology, Imperial College London, London, United Kingdom
    PLoS Pathog 4:e1000154. 2008
  5. pmc Restoration of NET formation by gene therapy in CGD controls aspergillosis
    Matteo Bianchi
    Division of Immunology Haematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    Blood 114:2619-22. 2009
  6. ncbi Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:909-17. 2002
  7. pmc Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection
    Markus Schrettl
    Biocenter Divison of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 3:1195-207. 2007
  8. ncbi Aspergillus fumigatus: contours of an opportunistic human pathogen
    Allison McCormick
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
    Cell Microbiol 12:1535-43. 2010
  9. pmc HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
  10. ncbi Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008

Detail Information

Publications343 found, 100 shown here

  1. ncbi Aspergillosis case-fatality rate: systematic review of the literature
    S J Lin
    Department of Pharmacy Administration, University of Illinois at Chicago, Chicago, IL, USA
    Clin Infect Dis 32:358-66. 2001
    To update the case-fatality rate (CFR) associated with invasive aspergillosis according to underlying conditions, site of infection, and antifungal therapy, data were systematically reviewed and pooled from clinical trials, cohort or ..
  2. pmc Aspergillus fumigatus and aspergillosis
    J P Latge
    Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris, France
    Clin Microbiol Rev 12:310-50. 1999
    ..in the immunocompetent host by innate immune mechanisms, and aspergilloma and allergic bronchopulmonary aspergillosis, uncommon clinical syndromes, are the only infections observed in such hosts. Thus, A...
  3. doi Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America
    Thomas J Walsh
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Infect Dis 46:327-60. 2008
  4. pmc Sub-telomere directed gene expression during initiation of invasive aspergillosis
    Andrew McDonagh
    Department of Microbiology, Imperial College London, London, United Kingdom
    PLoS Pathog 4:e1000154. 2008
    ..Immune dysfunction permits developmental growth of inhaled spores in the human lung causing aspergillosis, a significant threat to human health in the form of allergic, and life-threatening invasive infections...
  5. pmc Restoration of NET formation by gene therapy in CGD controls aspergillosis
    Matteo Bianchi
    Division of Immunology Haematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    Blood 114:2619-22. 2009
    ..Invasive aspergillosis is the leading cause of death in patients with CGD; it is unclear how neutrophils control Aspergillus species ..
  6. ncbi Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:909-17. 2002
    ..After 1992, the incidence of invasive aspergillosis increased in allograft recipients and remained high through the 1990s...
  7. pmc Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection
    Markus Schrettl
    Biocenter Divison of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 3:1195-207. 2007
    ..Our findings reveal distinct cellular and disease-related roles for intra- and extracellular siderophores during mammalian Aspergillus infection...
  8. ncbi Aspergillus fumigatus: contours of an opportunistic human pathogen
    Allison McCormick
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
    Cell Microbiol 12:1535-43. 2010
    ..It is able to cause several forms of disease in humans of which invasive aspergillosis is the most severe...
  9. pmc HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Innsbruck, Austria
    PLoS Pathog 6:e1001124. 2010
    ..iron starvation in the host, HapX-deficiency causes significant attenuation of virulence in a murine model of aspergillosis. Taken together, this study demonstrates that HapX-dependent adaption to conditions of iron starvation is ..
  10. ncbi Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
    ..step in tryptophan metabolism along the kynurenine pathway is blocked in CGD mice with lethal pulmonary aspergillosis, leading to unrestrained Vgamma1(+) gammadelta T-cell reactivity, dominant production of interleukin (IL)-17, ..
  11. pmc Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study
    Livio Pagano
    M D Istituto di Ematologia, Universita Cattolica del Sacro Cuore, Largo Francesco Vito, 1 I 00168 Roma, Italia
    Haematologica 95:644-50. 2010
    The aim of this study was to evaluate prognostic factors, treatments and outcome of invasive aspergillosis in patients with acute myeloid leukemia based on data collected in a registry.
  12. ncbi The clinical spectrum of pulmonary aspergillosis
    Ayman O Soubani
    Division of Pulmonary, Critical Care, and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Chest 121:1988-99. 2002
    ..syndromes in the lung, ranging from aspergilloma in patients with lung cavities, to chronic necrotizing aspergillosis in those who are mildly immunocompromised or have chronic lung disease...
  13. pmc The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus
    Chad Steele
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, USA
    PLoS Pathog 1:e42. 2005
    ..fumigatus and to our knowledge provides the first in vivo evidence for the role of dectin-1 in fungal innate defense...
  14. ncbi Aspergillus fumigatus: saprophyte or pathogen?
    Fredj Tekaia
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927, Universite Pierre et Marie Curie, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris, France
    Curr Opin Microbiol 8:385-92. 2005
    ..fumigatus in an unfriendly environment such as its human host...
  15. pmc A novel glyco-conjugate vaccine against fungal pathogens
    Antonella Torosantucci
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Exp Med 202:597-606. 2005
    ..fumigatus hyphae. Thus, this novel conjugate vaccine can efficiently immunize and protect against two major fungal pathogens by mechanisms that may include direct antifungal properties of anti-beta-glucan antibodies...
  16. ncbi The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo
    Silvia Bellocchio
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 172:3059-69. 2004
    ..albicans and A. fumigatus require the coordinated action of distinct members of the IL-1R/TLR superfamily acting through MyD88 makes TLR manipulation amenable to the induction of host resistance to fungi...
  17. pmc Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation
    Katia Perruccio
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51 06122 Perugia, Italy
    Blood 106:4397-406. 2005
    ..This study opens new perspectives for reducing infectious mortality after haploidentical transplantations...
  18. ncbi Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis
    Monique A S H Mennink-Kersten
    Department of Medical Microbiology, University Medical Center St Radboud, Nijimegen, The Netherlands
    Lancet Infect Dis 4:349-57. 2004
    ..that detects circulating galactomannan, has been a major advance for managing patients at risk for invasive aspergillosis because of the early detection of the antigen...
  19. ncbi Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality
    Arlo Upton
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    Clin Infect Dis 44:531-40. 2007
    Invasive aspergillosis (IA) is a leading cause of infection-related mortality following hematopoietic cell transplantation (HCT)...
  20. ncbi Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2
    Kathrin Luther
    Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
    Cell Microbiol 9:368-81. 2007
    ..Additionally we found that TLR2 and the adaptor protein MyD88 are required for efficient conidial phagocytosis, suggesting a link between the TLR2-mediated recognition of A. fumigatus and the phagocytic response...
  21. pmc Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism
    Eveline Snelders
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Med 5:e219. 2008
    ..to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive aspergillosis. The prevalence of azole resistance in A. fumigatus is unknown...
  22. pmc Aspergillus fumigatus mitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis
    Nora Grahl
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, MT, USA
    Mol Microbiol 84:383-99. 2012
    ..Thus, our results demonstrate a previously unidentified role for fungal mitochondrial respiration in the pathogenesis of aspergillosis, and lay the foundation for future research into its role in hypoxia signalling and adaptation.
  23. pmc Fungal antioxidant pathways promote survival against neutrophils during infection
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Invest 122:2482-98. 2012
    ..Further, these findings also indicate that targeting fungal anti-oxidative defenses via PX-12 may represent an efficacious strategy for treating fungal infections...
  24. ncbi Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry
    William J Steinbach
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Infect 65:453-64. 2012
    The study investigated the epidemiology and outcome of invasive aspergillosis (IA), an important cause of morbidity and mortality in immunocompromised patients.
  25. ncbi Invasive aspergillosis in critically ill patients without malignancy
    Wouter Meersseman
    Medical Intensive Care Unit, Department of General Internal Medicine, University Hospital, Leuven, Belgium
    Am J Respir Crit Care Med 170:621-5. 2004
    Using criteria designed for invasive aspergillosis (IA) in patients with cancer, we aimed to determine the impact of IA in patients without malignancy in a medical intensive care unit (ICU)...
  26. pmc Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
    Brad E Morrison
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9034, USA
    J Clin Invest 112:1862-70. 2003
    Invasive aspergillosis is a severe pneumonia that is usually fatal despite currently available therapy...
  27. ncbi Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
    Kieren A Marr
    Fred Hutchinson Cancer Research Center Programs in Infectious Diseases and Long term Follow up, Seattle, WA 98109, USA
    Blood 100:4358-66. 2002
    The incidence of postengraftment invasive aspergillosis (IA) in hematopoietic stem cell transplant (HSCT) recipients increased during the 1990s...
  28. ncbi Gliotoxin from Aspergillus fumigatus affects phagocytosis and the organization of the actin cytoskeleton by distinct signalling pathways in human neutrophils
    Christine Comera
    INRA UR 66 Laboratoire de Pharmacologie et Toxicologie, 180 chemin de Tournefeuille, 31931 Toulouse Cedex 9, France
    Microbes Infect 9:47-54. 2007
    ..on human neutrophils at concentrations corresponding to those found in the blood of patients with invasive aspergillosis. Incubation of the cells for 10min with 30-100ng/ml of gliotoxin inhibited phagocytosis of either zymosan or ..
  29. pmc Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice
    Hemanth Ramaprakash
    Immunology Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Infect Immun 77:108-19. 2009
    ..We investigated the role of TLR9 in murine models of invasive aspergillosis and fungal asthma...
  30. pmc Factors associated with mortality in transplant patients with invasive aspergillosis
    John W Baddley
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, AL 35294 0006, USA
    Clin Infect Dis 50:1559-67. 2010
    Invasive aspergillosis (IA) is an important cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients...
  31. ncbi Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence
    Michail S Lionakis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 191:1188-95. 2005
    Invasive aspergillosis (IA) is the most important opportunistic mycosis in immunosuppressed patients...
  32. ncbi Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Blood 116:5394-402. 2010
    ..stop codon polymorphism leading to diminished Dectin-1 receptor activity was studied in relation to invasive aspergillosis susceptibility and severity in patients receiving hematopoietic stem cell transplantation...
  33. ncbi An extracellular matrix glues together the aerial-grown hyphae of Aspergillus fumigatus
    Anne Beauvais
    Aspergillus Unit, Institut Pasteur, Paris, France
    Cell Microbiol 9:1588-600. 2007
    ..development of a colony of tightly associated hyphae in contact with the air, either in the alveoli (invasive aspergillosis) or in an existing cavity (aspergilloma)...
  34. pmc GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA
    Infect Immun 74:6761-8. 2006
    ..This may indicate that several secondary metabolites are involved in A. fumigatus virulence...
  35. pmc The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence
    Anna H T Hissen
    Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
    Infect Immun 73:5493-503. 2005
    ..Unlike the wild-type and rescued strains, the DeltasidA strain was avirulent in a mouse model of invasive aspergillosis, indicating that sidA is necessary for A. fumigatus virulence.
  36. ncbi Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus
    Olaf Beck
    Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Blood 107:2562-9. 2006
    Invasive aspergillosis remains a serious complication in patients undergoing allogeneic stem cell transplantation (SCT)...
  37. ncbi Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus
    S Ascioglu
    Clin Infect Dis 34:7-14. 2002
    ..quot; The definitions are intended for use in the context of clinical and/or epidemiological research, not for clinical decision making...
  38. ncbi Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis
    Carlo Mengoli
    Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, Padua, Italy
    Lancet Infect Dis 9:89-96. 2009
    A systematic review and meta-analysis was done on the use of PCR tests for the diagnosis of invasive aspergillosis. Data from more than 10000 blood, serum, or plasma samples obtained from 1618 patients at risk for invasive aspergillosis ..
  39. ncbi PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages
    Bernhard Jahn
    Institut fur Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg Universitat Mainz, Hochhaus am Augustusplatz, D 55101 Mainz, Germany
    Cell Microbiol 4:793-803. 2002
    ..Because macrophage-mediated killing is critical for host resistance to aspergillosis, the interaction of both grey-green wild-type conidia and white pksP mutant conidia with human monocyte-..
  40. pmc The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus
    Burghard Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Infect Immun 72:5193-203. 2004
    ..Taken together, these findings indicate that the cAMP-PKA signal transduction pathway is required for A. fumigatus pathogenicity...
  41. pmc Aspergillus infections in transplant recipients
    Nina Singh
    University of Pittsburgh Medical Center, VA Medical Center, Infectious Disease Section, University Dr C, Pittsburgh, PA 15240, USA
    Clin Microbiol Rev 18:44-69. 2005
    ..Management of invasive aspergillosis continues to be challenging, and the mortality rate, despite the use of newer antifungal agents, remains ..
  42. ncbi Aspergillus flavus: human pathogen, allergen and mycotoxin producer
    M T Hedayati
    Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
    Microbiology 153:1677-92. 2007
    ..fumigatus, for unclear reasons. After A. fumigatus, A. flavus is the second leading cause of invasive aspergillosis and it is the most common cause of superficial infection. Experimental invasive infections in mice show A...
  43. pmc Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Prasanna D Khot
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    BMC Infect Dis 8:73. 2008
    The diagnosis of invasive pulmonary aspergillosis (IPA) remains challenging...
  44. ncbi Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus
    Silvia Bozza
    Microbiology and Anatomy Sections, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    J Immunol 168:1362-71. 2002
    ..The invasive pulmonary aspergillosis is the most common manifestation of Aspergillus fumigatus infection in immunocompromised patients and is ..
  45. pmc Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles
    Eveline Snelders
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, The Netherlands
    Appl Environ Microbiol 75:4053-7. 2009
    ..the emergence of resistance to medical triazoles of Aspergillus fumigatus isolates from patients with invasive aspergillosis. A dominant resistance mechanism was found, and we hypothesized that azole resistance might develop through ..
  46. ncbi Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis
    A Carvalho
    School of Health Sciences, University of Minho, Braga, Portugal
    J Infect Dis 197:618-21. 2008
    ..between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary ..
  47. ncbi Multiple-triazole-resistant aspergillosis
    Paul E Verweij
    N Engl J Med 356:1481-3. 2007
  48. ncbi Antifungal activity of statins against Aspergillus species
    Jianjun Qiao
    Department of Dermatology, Peking University First Hospital, and Research Center for Medical Mycology, Peking University, Beijing, China
    Med Mycol 45:589-93. 2007
    ..The results of a combined agar dilution-Epsilometer test as well as a disk diffusion assay showed that neither statin had any effect on the in vitro activities of itraconazole, voriconazole, or amphotericin B against Aspergillus spp...
  49. pmc Standardization of an experimental murine model of invasive pulmonary aspergillosis
    Donald C Sheppard
    McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada
    Antimicrob Agents Chemother 50:3501-3. 2006
    Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories...
  50. ncbi Production of melanin by Aspergillus fumigatus
    Sirida Youngchim
    Dermatology Department, St Johns Institute of Dermatology, Guy s Hospital, Kings and St Thomas Medical Schools, London, UK
    J Med Microbiol 53:175-81. 2004
    ..Melanin-binding mAbs were used to detect the presence of melanized conidia in three patients with nasal aspergilloma, indicating that in vivo melanization may occur during infection...
  51. pmc Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production
    Robert A Cramer
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 5:972-80. 2006
    ..produced by Aspergillus fumigatus has been hypothesized to be important in the development of invasive aspergillosis. In this study, we addressed this hypothesis by disrupting a nonribosomal peptide synthetase (NRPS) (encoded ..
  52. ncbi Changes in causes of death over time after treatment for invasive aspergillosis
    John R Wingard
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 3633, USA
    Cancer 112:2309-12. 2008
    Assessment of response to invasive aspergillosis (IA) therapy has been challenging in treatment trials.
  53. pmc Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites
    Ronen Ben-Ami
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 114:5393-9. 2009
    ..we devised an in vivo Matrigel assay in cyclophosphamide-treated BALB/c mice with cutaneous invasive aspergillosis. Angiogenesis was significantly suppressed in Matrigel plugs implanted in A fumigatus-infected mice compared ..
  54. pmc Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus
    Robert A Cramer
    Duke University Medical Center, Box 3499, Pediatric Infectious Diseases, Durham, NC 27710, USA
    Eukaryot Cell 7:1085-97. 2008
    ..of causing disease in an experimental persistently neutropenic inhalational murine model of invasive pulmonary aspergillosis. Our results suggest that CrzA is an important downstream effector of calcineurin that controls morphology in ..
  55. ncbi Immune sensing of Aspergillus fumigatus proteins, glycolipids, and polysaccharides and the impact on Th immunity and vaccination
    Silvia Bozza
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:2407-14. 2009
    ..This suggests that the broadness and specificity of human T cell repertoire against the fungus could be selectively exploited with defined immunoactive Aspergillus Ags...
  56. pmc Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis
    S Kaur
    Molecular Biochemistry and Diagnostics, Institute of Genomics and Integrative Biology, Mall Road, Delhi, India
    Clin Exp Immunol 148:382-9. 2007
    ..of externally administered recombinant human (rh) MBL towards anti-fungal defence in invasive pulmonary aspergillosis (IPA) by in vivo and in vitro studies...
  57. pmc Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis
    Stacy J Park
    Department of Microbiology, University of Virginia, Charlottesville, 22908, USA
    J Immunol 182:4306-12. 2009
    Invasive aspergillosis is among the most common human fungal infections and occurs in patients with severe and complex defects in immune responses...
  58. ncbi Galactomannan and PCR versus culture and histology for directing use of antifungal treatment for invasive aspergillosis in high-risk haematology patients: a randomised controlled trial
    C Orla Morrissey
    Infectious Diseases Unit, Alfred Health, and Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Vic, Australia
    Lancet Infect Dis 13:519-28. 2013
    Empirical treatment with antifungal drugs is often used in haematology patients at high risk of invasive aspergillosis. We compared a standard diagnostic strategy (culture and histology) with a rapid biomarker-based diagnostic strategy (..
  59. ncbi Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis
    P Bonifazi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Mucosal Immunol 3:193-205. 2010
    ..Thus, the screening of signaling pathways in DCs through a systems biology approach may be exploited for the development of siRNA therapeutics to attenuate inflammation in respiratory fungal infections and diseases...
  60. pmc Immunoproteomics based identification of thioredoxin reductase GliT and novel Aspergillus fumigatus antigens for serologic diagnosis of invasive aspergillosis
    Li ning Shi
    Laboratory of Molecular Biology, Institute of Medical Laboratory Sciences, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, PR China
    BMC Microbiol 12:11. 2012
    There has been a rising incidence of invasive aspergillosis (IA) in critically ill patients, even in the absence of an apparent predisposing immunodeficiency...
  61. ncbi Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia
    D Caillot
    Department of Clinical Hematology, University Hospital of Dijon, Dijon, France
    J Clin Oncol 19:253-9. 2001
    In patients with neutropenia, thoracic computed tomography (CT) halo and air-crescent signs are recognized as major indicators of invasive pulmonary aspergillosis (IPA). Nevertheless, the exact timing of CT images is not well known.
  62. pmc Anticoagulants interfere with PCR used to diagnose invasive aspergillosis
    Marta E Garcia
    J Clin Microbiol 40:1567-8. 2002
  63. ncbi Invasive aspergillosis in developing countries
    Arunaloke Chakrabarti
    Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Med Mycol 49:S35-47. 2011
    To review invasive aspergillosis (IA) in developing countries, we included those countries, which are mentioned in the document of the International Monetary Fund (IMF), called the Emerging and Developing Economies List, 2009...
  64. ncbi Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent
    Matteo Bianchi
    Division of Immunology Hematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    J Allergy Clin Immunol 127:1243-52.e7. 2011
    ..This process is defective in chronic granulomatous disease (CGD) because of impaired phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function...
  65. pmc Efficacy of PTX3 in a rat model of invasive aspergillosis
    Pietro Lo Giudice
    R and D Department, Sigma Tau SpA00040 Pomezia, RM, Italy
    Antimicrob Agents Chemother 54:4513-5. 2010
    ..PTX3 activity was evaluated against pulmonary aspergillosis in rats immunosuppressed with cortisone acetate...
  66. pmc Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document)
    A Espinel-Ingroff
    VCU Medical Center, 3804 Dover Rd, Richmond, VA 23221, USA
    J Clin Microbiol 48:3251-7. 2010
    ..These ECVs should be considered for inclusion in the future CLSI M38-A2 document revision...
  67. ncbi Invasive mycoses: strategies for effective management
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Med 125:S25-38. 2012
    ..This article discusses strategies for the effective management of invasive mycoses, with a particular focus on antifungal hepatotoxicity...
  68. ncbi Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6
    Ivana Rubino
    Department of Medicine, University of Lausanne, Switzerland
    J Infect Dis 205:944-54. 2012
    Aspergillus fumigatus causes invasive aspergillosis, a potentially fatal infection in oncohematological patients. Innate immune detection of A...
  69. pmc A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus
    Zaida G Ramirez-Ortiz
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell Host Microbe 9:415-24. 2011
    ..resulted in a substantial influx of pDCs into lungs, and pDC-depleted mice were hypersusceptible to invasive aspergillosis. These data demonstrate the antifungal activity of pDCs against A...
  70. ncbi Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group
    T F Patterson
    Division of Infectious Diseases, University of Texas Health Science Center, San Antonio 78284 7881, USA
    Medicine (Baltimore) 79:250-60. 2000
    A review of representative cases of invasive aspergillosis was conducted to describe current treatment practices and outcomes...
  71. pmc Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture
    Ana C Vallor
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 52:2593-8. 2008
    Early diagnosis of invasive pulmonary aspergillosis is problematic in some patient groups due to the lack of rapid, sensitive, specific, and reliable diagnostic tests...
  72. ncbi Interstrain variability in the virulence of Aspergillus fumigatus and Aspergillus terreus in a Toll-deficient Drosophila fly model of invasive aspergillosis
    Ronen Ben-Ami
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Med Mycol 48:310-7. 2010
    ..of Aspergillus fumigatus and Aspergillus terreus isolates using a previously described model of invasive aspergillosis in Toll-deficient fruit flies...
  73. pmc Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity
    Ranjith Rajendran
    School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, and Microbiology Department, Royal Hospital for Sick Children, 378 Sauchiehall Street, Glasgow G2 3JZ, United Kingdom
    Antimicrob Agents Chemother 55:2092-7. 2011
    ..Moreover, voriconazole treatment induces efflux pump expression. Collectively, these data may provide evidence for azole treatment failures in clinical cases of aspergillosis.
  74. pmc Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole
    Saskia Kuipers
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, Netherlands
    Antimicrob Agents Chemother 55:3564-6. 2011
    We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy...
  75. ncbi Genetic re-identification and antifungal susceptibility testing of Aspergillus section Nigri strains of the BCCM/IHEM collection
    M Hendrickx
    Department of Mycology and Aerobiology, Scientific Institute of Public Health, Brussels, Belgium
    Mycoses 55:148-55. 2012
    ..tubingensis. These findings underline once more the importance of correct identification up to the species level in clinical isolates...
  76. pmc The Y238X stop codon polymorphism in the human β-glucan receptor dectin-1 and susceptibility to invasive aspergillosis
    Louis Y A Chai
    Department of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    J Infect Dis 203:736-43. 2011
    ..We investigated whether defective Dectin-1 receptor function, because of the early stop codon polymorphism Y238X, enhances susceptibility to invasive aspergillosis (IA) in at-risk patients.
  77. ncbi Invasive pulmonary aspergillosis in patients with hematologic malignancies: survival and prognostic factors
    Maricel Subirá
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Av S A M Claret 167, 08025 Barcelona, Spain
    Haematologica 87:528-34. 2002
    Despite improvements made in its early diagnosis and effective treatment, invasive pulmonary aspergillosis (IPA) remains a devastating opportunistic infection...
  78. ncbi Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran
    Gyöngyi Szigeti
    Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary
    Mycoses 55:333-8. 2012
    ..Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings...
  79. ncbi Identification of virulence factors and diagnostic markers using immunosecretome of Aspergillus fumigatus
    Awanit Kumar
    Medical Mycology Lab, Division of Fermentation Technology, CSIR Central Drug Research Institute, Lucknow 226 001, India
    J Proteomics 74:1104-12. 2011
    Aspergillus fumigatus is a prime causative agent for various allergic and invasive aspergillosis. There has been a dramatic increase of such cases in last three decades yet the early diagnosis and virulence factor identification remains ..
  80. ncbi Analysis of the cellular Aspergillus fumigatus proteome that reacts with sera from rabbits developing an acquired immunity after experimental aspergillosis
    Abdul R Asif
    Department of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany
    Electrophoresis 31:1947-58. 2010
    Invasive aspergillosis caused by the mould Aspergillus fumigatus is a life-threatening lung or systemic infection in the immunocompromised host...
  81. ncbi Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer
    Gail Woods
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cancer 110:830-4. 2007
    Determining the outcome of patients with aspergillosis can be particularly difficult because patients with aspergillosis are at risk for other conditions that mimic this infection...
  82. pmc SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A)
    Sara J Blosser
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    Antimicrob Agents Chemother 56:248-57. 2012
    ..Taken together, our results demonstrate a critical role for SrbA-mediated regulation of ergosterol biosynthesis and triazole drug interactions in A. fumigatus that may have clinical importance...
  83. ncbi Antifungal combination therapy: clinical potential
    John W Baddley
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, and Birmingham Veteran s Administration Medical Center, Birmingham, Alabama 35294 0006, USA
    Drugs 65:1461-80. 2005
    ..growing interest in examining combination antifungal therapy for invasive fungal disease, especially invasive aspergillosis. This is by no means a comprehensive review of all existing experimental data...
  84. pmc Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature
    Simone M T Camps
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 56:10-6. 2012
    ..Furthermore, the median time between the last cultured wild-type isolate and the first azole-resistant isolate was 4 months (range, 3 weeks to 23 months), indicating a rapid induction of resistance...
  85. ncbi Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009
    Ahmed Bueid
    The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Antimicrob Chemother 65:2116-8. 2010
    ..Resistance to azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in some locations. Here we update our previous experience with data from 2008-09...
  86. pmc Cutaneous model of invasive aspergillosis
    Ronen Ben-Ami
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Antimicrob Agents Chemother 54:1848-54. 2010
    ..Because cutaneous invasive aspergillosis (IA) occurs in the clinical setting, we sought to develop a nonlethal murine cutaneous model of IA...
  87. ncbi TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
    Sandra Kesh
    Department of Medicine, Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 9, New York, NY 10021, USA
    Ann N Y Acad Sci 1062:95-103. 2005
    ..between single nucleotide polymorphisms (SNPs) in TLR1, TLR4, and TLR6 genes and development of invasive aspergillosis (IA) in 127 allogeneic hematopoietic stem cell transplant recipients consisting of 22 patients with IA and 105 ..
  88. ncbi Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells
    Markus Mezger
    Julius Maximilians Universitat Wurzburg, Medizinische Klinik und Poliklinik II, Germany
    Blood 111:534-6. 2008
    Patients after allogeneic stem-cell transplantation (alloSCT) have an increased risk for invasive aspergillosis (IA)...
  89. ncbi Central nervous system aspergillosis: a 20-year retrospective series
    B K Kleinschmidt-Demasters
    Department of Pathology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hum Pathol 33:116-24. 2002
    Over the past 20 years at my institution, 71 patients with invasive necrotizing aspergillosis have been encountered; 42 have shown central nervous system (CNS) involvement by autopsy (40) or surgical biopsy (2)...
  90. ncbi The immune response to fungal infections
    Shmuel Shoham
    Section of Infectious Diseases, Washington Hospital Center, Washington, DC, USA
    Br J Haematol 129:569-82. 2005
    ..An understanding of the host response to these organisms is important in decisions regarding use of currently available antifungal therapies and in the design of new therapeutic modalities...
  91. ncbi Epidemiology of invasive aspergillosis in France: a six-year multicentric survey in the Greater Paris area
    M Cornet
    Service Evaluation Qualité Accréditation et Sécurité Sanitaire, Direction de la Politique Médicale, AP HP, Paris, France
    J Hosp Infect 51:288-96. 2002
    Invasive aspergillosis is the most prevalent mould infection. An epidemiological surveillance network was set up in 18 teaching hospitals in Paris and the Greater Paris area. Prospective surveillance was conducted between 1994 and 1999...
  92. pmc The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages
    Markus Schrettl
    Division of Molecular Biology Biocenter, Innsbruck Medical University, Fritz Pregl Str 3, 6020 Innsbruck, Austria
    Microbes Infect 12:1035-41. 2010
    ....
  93. ncbi Diagnosis of invasive aspergillosis by galactomannan antigenemia detection using an enzyme immunoassay
    L J Wheat
    MiraVista Diagnostics and MiraBella Technologies, MiraVista Diagnostics, 4444 Decatur Blvd, Indianapolis, IN 46241, USA
    Eur J Clin Microbiol Infect Dis 27:245-51. 2008
    Invasive aspergillosis is a serious and often fatal infection in patients who are neutropenic or have undergone solid organ or stem cell transplantation. Delayed diagnosis and therapy may lead to poor outcomes...
  94. ncbi Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey
    A Cornillet
    Laboratoire de Parasitologie Mycologie, Hopital Pontchaillou, Rennes, France
    Clin Infect Dis 43:577-84. 2006
    Invasive aspergillosis is an opportunistic infection that occurs mainly among patients with prolonged neutropenia. Few data are available on invasive aspergillosis in nonneutropenic patients.
  95. pmc The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice
    Julian Pardo
    Metschnikoff Laboratory, Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
    J Cell Biol 174:509-19. 2006
    ..The elucidation of the molecular basis opens new strategies for the development of therapeutic regimens to combat A. fumigatus and related fungal infections...
  96. pmc Immune responses against Aspergillus fumigatus: what have we learned?
    Robert A Cramer
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    Curr Opin Infect Dis 24:315-22. 2011
    ..This review covers the molecular and cellular events that mediate innate and CD4 T-cell responses to A. fumigatus and fungal attributes that counter hostile microenvironments and, in turn, affect host responses...
  97. pmc Aspergillus fumigatus MedA governs adherence, host cell interactions and virulence
    Fabrice N Gravelat
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    Cell Microbiol 12:473-88. 2010
    ..strain also exhibited reduced virulence in both an invertebrate and a mammalian model of invasive aspergillosis. Collectively, these results suggest that the downstream targets of A...
  98. ncbi Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability
    Isabelle Mouyna
    Unite des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux 75724 Paris Cedex 15, France
    Mol Microbiol 76:1205-21. 2010
    ..These results indicate that the PMT family members play a major role in growth, morphogenesis and viability of A. fumigatus...
  99. ncbi Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants
    Axel A Brakhage
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Curr Drug Targets 6:875-86. 2005
    ..medicine and the therapy of hematological malignancies is often complicated by the threat of invasive aspergillosis. Specific diagnostics are still limited, as are the possibilities of therapeutic intervention...
  100. ncbi Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies
    Holger Hebart
    Department of Hematology and Oncology, Institute for Medical Information Processing, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Blood 100:4521-8. 2002
    Invasive aspergillosis has become a major cause of infection-related mortality in nonneutropenic patients after allogeneic stem cell transplantation (SCT)...
  101. pmc Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence
    Ilse D Jacobsen
    Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Infect Immun 78:2995-3006. 2010
    ..previously shown to be fully virulent or partially or strongly attenuated in a mouse model of bronchopulmonary aspergillosis showed comparable degrees of attenuation in the egg model...

Research Grants64

  1. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..for hematologic malignancies or bone marrow transplantation are at increased risk for developing invasive aspergillosis (IA). IA is a difficult to treat, opportunistic infection with reported mortality rates in excess of 50%...
  2. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is associated with mortality rates of 40- 50%...
  3. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    Invasive aspergillosis (IA) is one of the most serious causes of morbidity and mortality among immune compromised patients. Mortality may exceed 50% despite aggressive antifungal therapy...
  4. Identification and Analysis of Circadian Clock-Controlled Genes
    Jennifer J Loros; Fiscal Year: 2013
    ..our understanding of fungal photobiology to enable a new treatment for hundreds of thousands of patients with aspergillosis. In Specific Aim 3, we will use RNA sequencing to determine the circadian profile of clock-controlled genes in ..
  5. Manipulation of Host Angiogenesis as a Therapeutic Strategy against Invasive Pulm
    Dimitrios P Kontoyiannis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) is an important cause of respiratory and disseminated infection in immunocompromised patients, and the most common cause of infectious pneumonic mortality in recipients of ..
  6. Host Factors in Fungal Allergy and Fibrosis
    Anuradha Ray; Fiscal Year: 2010
    ..with Cystic Fibrosis that have defined Aspergillus colonization with and without Allergic Bronchopulmonary Aspergillosis (ABPA) and a basic science project that uses a novel rodent model of immune tolerance or allergy to define the ..
  7. Non-oxidative Resistance to A. fumigatus by Alveolar Macrophages
    James B Burritt; Fiscal Year: 2010
    ..IPA are conflicting, and our data do not indicate the respiratory burst in AM is necessary for a resistance to aspergillosis, as we have shown it is in neutrophils...
  8. Initiation of the Immune Response to Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Unchecked spore germination in the lung leads to invasive aspergillosis (IA), a major cause of infectious morbidity and mortality in immune compromised hosts...
  9. Role of transcriptional regulation in Aspergillus fumigatus drug resistance
    W Scott Moye-Rowley; Fiscal Year: 2012
    ..Invasive aspergillosis has up to a 90% mortality rate in particular patient populations, primarily among patient groups with reduced ..
  10. Interactions of pDCs with Aspergilus
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..We hypothesize that pDCs play a major role in host defenses against invasive aspergillosis by mediating direct antifungal activity and by modulating the innate and adaptive immune response...
  11. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2013
    ..Improved outcome in patients with invasive aspergillosis has been directly linked to earlier diagnosis, underscoring the need for more accurate diagnostic tests...
  12. A Structural Approach for Treating Drug Resistant Fungal Pathogens
    Mitchell W Mutz; Fiscal Year: 2013
    ..Nosocomial infections caused by Candida albicans have a 50% mortality rate. Aspergillosis is a leading cause of death in organ transplant recipients, as well as patients suffering from cancer and auto-..
  13. A Combination Therapy Approach to Treating Drug Resistant Fungal Infections
    Mitchell W Mutz; Fiscal Year: 2011
    ..Nosocomial infections caused by Candida albicans have a 50% mortality rate. Aspergillosis is a leading cause of death in organ transplant recipients, as well as patients suffering from cancer and auto-..
  14. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..and rabbit);and 4) define the breadth of protection of ATAK cells against three highly lethal mold infections: aspergillosis, mucormycosis, or fusariosis...
  15. Identification of calcineurin-binding proteins in A. fumigatus septum formation
    William J Steinbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus has surpassed invasive candidiasis as the most frequent fungal cause of death in immunocompromised patients...
  16. Novel Biomarkers for Early Detection of Aspergillosis
    Ram Ramabhadran; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus is the most frequent fungal cause of death in immunocompromised patients...
  17. Control of Aspergillus fumigatus polarized growth through regulation of Ras prote
    Jarrod Fortwendel; Fiscal Year: 2013
    ..fumigatus to invade lung tissues. Despite current antifungal therapy, invasive aspergillosis (IA) caused by A. fumigatus continues to have high morbidity and mortality in immunocompromised patients...
  18. Aspergillus-specific CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2010
    ..intense chemotherapy regimens and bone marrow transplanted patients are particularly at risk for Invasive Aspergillosis (IA) with an associated mortality rate of approximately 90%...
  19. The role of TLR9 on Aspergillus fumigatus phagosomes
    Jatin M Vyas; Fiscal Year: 2013
    ..10% of patients with hematopoietic stem cell transplants or solid organ transplants will develop invasive aspergillosis, a life-threatening infection...
  20. Transcriptional regulation of A. fumigatus virulence
    Scott G Filler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis is one of the most feared diseases in the immunocompromised host, and its incidence is steadily increasing...
  21. Innovative Assay Development for the Diagnosis of Invasive Aspergillosis
    Marc D Porter; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Invasive Aspergillosis (IA) is a devastating and frequently fatal infection in immunocompromised patients, in part because of poor early detection tools. It presently kills 52% of those infected...
  22. Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence
    William J Steinbach; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is a leading cause of death in immunocompromised patients. Current IA therapy has a disappointing treatment success rate...
  23. The systems biology of iron homeostasis and the immune response to Aspergillus
    CHRISTOPHER BRIAN LAWRENCE; Fiscal Year: 2013
    ..to better understand the biology and virulence of Aspergillus fumigatus, the causative agent of invasive aspergillosis (IA), the host immune response, and the role of iron in the interaction between fungus and host...
  24. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive pulmonary aspergillosis caused by the mold Aspergillus fumigatus has emerged as one of the most severe invasive fungal infections, not only in an expanding population of immunosuppressed ..
  25. Dectin-1 and Invasive Pulmonary Aspergillosis
    Chad Steele; Fiscal Year: 2010
    ..fumigatus and successful host defense against invasive pulmonary aspergillosis. We plan to test our hypothesis with the following Specific Aims: (1) To test the hypothesis that Dectin-1 is ..
  26. Dissection of Macrophage Antifungal Activity against Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Conidial germination into tissue-invasive hyphae leads to invasive aspergillosis (IA), a devastating cause of infectious morbidity and mortality in patients with impaired respiratory innate ..
  27. High-density lipoprotein and A. fumigatus pathogenesis
    David S Askew; Fiscal Year: 2013
    ..The purpose of this study is to explore a new link between HDL and the defense against invasive aspergillosis (IA), a life-threatening infection caused by the mold pathogen Aspergillus fumigatus...
  28. Echinocandin Resistance in Aspergillus
    Gregory S May; Fiscal Year: 2010
    ..echinocandin class of antifungal drugs, such as casiofungin, are increasingly being used to treat invasive aspergillosis (IA) a frequently life threatening disease that even with antifungal therapy has a mortality rate approaching ..
  29. ER stress and virulence of Aspergillus fumigatus
    David S Askew; Fiscal Year: 2012
    ..Despite some advances in therapy, invasive aspergillosis continues to have a poor outcome, emphasizing the need for more information on fungal pathways that are ..
  30. Clinical and Molecular Phenotypes of Severe Asthma
    John V Fahy; Fiscal Year: 2013
    ..we hypothesize to have a pathogenic role in the mechanism of mucus plug formation in Allergic Bronchopulmonary Aspergillosis, an important subtype of severe asthma...
  31. NK cells in host defense against invasive aspergillosis
    Borna Mehrad; Fiscal Year: 2013
    Invasive aspergillosis is a common fungal infection in immunocompromised patients and carries a poor prognosis...
  32. MECHANISMS OF ANTIGEN INDUCED TOLERANCE IN THE LUNG
    Anuradha Ray; Fiscal Year: 2013
    ..found a role for vitamin D3 in promoting mTGF-[unreadable] cells in the context of allergic bronchopulmonary aspergillosis (ABPA)...
  33. Role of CCR2+ monocytes and Mo-DCs in defense against IA and GVHD development
    Amariliz Rivera; Fiscal Year: 2013
    ..has been hampered by serious complications including life-threatening fungal infections (especially invasive aspergillosis, IA) and graft versus host disease (GVHD) development...
  34. Linking Triazole Resistance and Fitness in Aspergillus fumigatus
    David S Perlin; Fiscal Year: 2013
    ..Aspergillus fumigatus causes a wide spectrum of diseases including allergic syndromes, chronic pulmonary aspergillosis and acute invasive aspergillosis (IA)...
  35. 2010 Cell and Molecular Fungal Biology; Gordon Research Conference
    John W Taylor; Fiscal Year: 2010
    ..fungi in human disease, including two of the most important diseases of transplant patients, candidiasis and aspergillosis, and the systemic fungal diseases, coccidioidomycosis and histoplasmosis...
  36. Ontogeny of Voriconazole Pharmaockinetics and Metabolism
    Michael N Neely; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mortality in children from aspergillosis is more than 50%...
  37. Development of anti-Aspergillus single chain Abs as serum and imaging diagnostics
    Michael D Gunn; Fiscal Year: 2013
    Project Summary Invasive aspergillosis (IA) is the most common filamentous fungal infection in immunocompromised patients. Mortality in patients diagnosed with this condition ranges from 70% to 90% at one year...
  38. Virus Electrodes for Fungal Pathogen Detection
    Gary Fujii; Fiscal Year: 2009
    ..real-time basis could have a major impact on the early detection and diagnosis of infectious diseases, such as Aspergillosis, thus leading to improved outcomes in subsequent treatment...
  39. Immune regulatory mechanisms and fungus-specific memory T cell responses
    Vanessa Espinosa; Fiscal Year: 2013
    ..opportunistic fungal pathogen Aspergillus fumigatus is the causative agent of more than 90% of all Invasive Aspergillosis (IA) infections diagnosed in immunosuppressed patients. Exposure to A...
  40. 2012 Cellular and Molecular Fungal Biology Gordon Research Conference
    Judith G Berman; Fiscal Year: 2012
    ..including three of the most important diseases of transplant patients, candidiasis, cryptococcosis and aspergillosis, as well as systemic fungal diseases such as histoplasmosis...
  41. Amphotericin B Analogs
    Charles Hutchinson; Fiscal Year: 2009
    ..Amphotericin B (AMB) continues to be an important drug for invasive aspergillosis, candidemia, mucormycosis, fusariosis and Cryptococcosis meningitis because of its potency, broad spectrum of ..
  42. A Phylogenetic Approach to Virulence in Aspergillus
    Paul Bayman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) is a serious, frequently fatal, infection of immunocompromised patients. The most common pathogens, Aspergillus fumigatus and A...
  43. Cellular Mechanisms Governing an Invasive Aspergillosis Virulence Factor
    Graeme S Garvey; Fiscal Year: 2010
    ..Relevance: Aspergillus fumigatus, a ubiquitous environmental fungus, is the primary causal agent of invasive aspergillosis. Current treatments with antifungal agents is often ineffective with invasive aspergillosis mortality rates ..
  44. Hypoxia Adapatation and Fungal Virulence of Aspergillus fumigatus
    ROBERT ANDREW CRAMER; Fiscal Year: 2012
    Invasive aspergillosis (IA) is caused by the mould Aspergillus fumigatus and is an understudied disease of growing significance that causes over 3,500 deaths in the United States annually. The spectrum of patients susceptible to A...
  45. ASPERGILLUS ELASTASE, A POTENTIAL VIRULENCE FACTOR
    JUDITH RHODES; Fiscal Year: 1990
    b>Aspergillosis is increasing in frequency, as is the immunocompromised patient population most susceptible to the infection...
  46. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2001
    Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af)...
  47. ASPERGILLUS FUMIGATUS COMPLEMENT INHIBITOR
    RONALD WASHBURN; Fiscal Year: 1991
    ..of CI will be examined using labeled anti-CI IgG F(ab')2 in the cortisone-treated mouse model of invasive aspergillosis, and in available human tissues...
  48. GENOME SEQUENCING OF ASPERGILLUS FUMIGATUS
    David Denning; Fiscal Year: 2001
    Aspergillus fumigatus is the most common cause of life-threatening mold infection (aspergillosis). Its spores are found in the air everywhere and are therefore unavoidable...
  49. New methods for the early diagnosis of invasive fungal infections
    Maurizio Del Poeta; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Invasive fungal infections, such as cryptococcosis, candidiasis and aspergillosis, have dramatically emerged in the last two decades and are associated with very poor prognosis...
  50. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric G Pamer; Fiscal Year: 2010
    ..fumigatus is a spore forming mould that causes a range of human diseases, including allergic bronchopulmonary aspergillosis, an asthma-like disease, and invasive aspergillosis, a frequently fatal infection that occurs in ..
  51. Ambruticin for Aspergillus
    Leonard Katz; Fiscal Year: 2005
    The incidence of aspergillosis, and other invasive mould infections (IMIs), is increasing in hospitals worldwide at an alarming rate...
  52. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..The incidence of invasive aspergillosis (IA) has risen steadily over the past three decades, and mortality rates currently range from 45-90%...
  53. TWO-COMPONENT SIGNAL PROTEINS OF ASPERGILLUS FUMIGATUS
    Richard Calderone; Fiscal Year: 2003
    ..Dr. Latge's lab has made numerous contributions to our understanding of the pathogenesis of aspergillosis through both biochemical and molecular approaches. Dr...
  54. Lysine Biosynthesis in Yeast
    Paul Cook; Fiscal Year: 2007
    ..Candida albicans (responsible for [unreadable] candidiasis) and AspergiUus fumigatus (responsible for aspergillosis), and Cryptococcus neoformans [unreadable] (responsible for cryptococcosis)...
  55. Phagocyte Contact Response in Aspergillosis Immunity
    JAMES BURRITT; Fiscal Year: 2005
    ..Due to difficulties in managing A. fumigatus infections, most individuals that develop invasive aspergillosis will die. With an increasing immune compromised population, infections by A. fumigatus will also increase...
  56. THE ROLE OF CXC CHEMOKINES IN INVASIVE ASPERGILLOSIS
    Borna Mehrad; Fiscal Year: 2004
    Invasive pulmonary aspergillosis is a common and devastating complication of immunosuppression, and carries a mortality of greater than 85 percent with optimal available therapy...
  57. Antifungal Drug Resistance in Aspergillus
    Kieren Marr; Fiscal Year: 2004
    ..At the same time that multiple drugs have become available for treatment of Invasive aspergillosis, antifungal drug resistance of Aspergillus is being recognized...
  58. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af)...
  59. Inhalable amphotericin B nanodisk therapy for pulmonary aspergillosis
    Trudy Forte; Fiscal Year: 2005
    ..The current first-line treatment for aspergillosis is amphotericin B (ampB) but it is both highly nephrotoxic and insoluble...
  60. Translation state array analysis in Aspergillus fumigatus
    David Askew; Fiscal Year: 2009
    ..PROJECT NARRATIVE: Major obstacles to the effective treatment of aspergillosis include the rapid growth of the organism in the host and the limited ability of current diagnostic methods to ..
  61. ASPERGILLOSIS--THE EVOLUTION BEHIND STRAIN TYPING
    John Taylor; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Aspergillosis has become an important fungal disease because it kills neutropenic patients, including those who are voluntarily immunosuppressed to facilitate bone marrow (BMT) or ..
  62. ASPERGILLUS ALLERGENS AND ALLERGIC ASPERGILLOSIS
    Viswanath Kurup; Fiscal Year: 2000
    ..Af) antigens for early diagnosis of Aspergillus and to understand the immunopathogenesis of allergic aspergillosis. Allergic bronchopulmonary aspergillosis (ABPA) is a destructive lung disease frequently occurring in atopic ..
  63. Aspergillus Angioinvasion and Dissemination
    Scott Filler; Fiscal Year: 2006
    ..Invasion of blood vessels is a hallmark pathologic feature of invasive aspergillosis and plays a critical role in the development of local and disseminated disease...
  64. ANTIMICROBIAL THERAPY OF SYSTEMIC MYCOTIC DISEASES
    William Dismukes; Fiscal Year: 1990
    ..of various single and multiple drug regimens for the therapy of cryptococcal meningitis and various forms of aspergillosis, coccidioidomycosis, blastomycosis, histoplasmosis, and candidiasis...