mycoses

Summary

Top Publications

  1. pmc Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) C
    Ben de Pauw
    Department of Blood Transfusion Service and Transplant Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 46:1813-21. 2008
  2. ncbi Epidemiology of invasive mycoses in North America
    Michael A Pfaller
    Department of Pathology, University of Iowa, Iowa City, USA
    Crit Rev Microbiol 36:1-53. 2010
  3. pmc Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America
    L Berger
    School of Public Health and Tropical Medicine, James Cook University, Townsville, Queensland 4811, Australia
    Proc Natl Acad Sci U S A 95:9031-6. 1998
  4. ncbi Diagnostic assays and sampling protocols for the detection of Batrachochytrium dendrobatidis
    A D Hyatt
    Australian Animal Health Laboratory, CSIRO Livestock Industries, Private Bag 24, Geelong, Victoria 3220, Australia
    Dis Aquat Organ 73:175-92. 2007
  5. ncbi Global emergence of Batrachochytrium dendrobatidis and amphibian chytridiomycosis in space, time, and host
    Matthew C Fisher
    Department of Infectious Disease Epidemiology, St Mary s Hospital, Imperial College, London W2 1PG, United
    Annu Rev Microbiol 63:291-310. 2009
  6. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
  7. pmc Emerging infectious disease and the loss of biodiversity in a Neotropical amphibian community
    Karen R Lips
    Department of Zoology, Southern Illinois University, Carbondale, 62901 6501, USA
    Proc Natl Acad Sci U S A 103:3165-70. 2006
  8. pmc Randomized, double-blind trial of fluconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantation
    John R Wingard
    University of Florida, Gainesville, FL, USA
    Blood 116:5111-8. 2010
  9. ncbi Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia
    Oliver A Cornely
    University of Cologne, Cologne, Germany
    N Engl J Med 356:348-59. 2007
  10. ncbi The ecology and impact of chytridiomycosis: an emerging disease of amphibians
    A Marm Kilpatrick
    Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064, USA
    Trends Ecol Evol 25:109-18. 2010

Detail Information

Publications294 found, 100 shown here

  1. pmc Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) C
    Ben de Pauw
    Department of Blood Transfusion Service and Transplant Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 46:1813-21. 2008
    ..Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies...
  2. ncbi Epidemiology of invasive mycoses in North America
    Michael A Pfaller
    Department of Pathology, University of Iowa, Iowa City, USA
    Crit Rev Microbiol 36:1-53. 2010
    The incidence of invasive mycoses is increasing, especially among patients who are immunocompromised or hospitalized with serious underlying diseases. Such infections may be broken into two broad categories: opportunistic and endemic...
  3. pmc Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America
    L Berger
    School of Public Health and Tropical Medicine, James Cook University, Townsville, Queensland 4811, Australia
    Proc Natl Acad Sci U S A 95:9031-6. 1998
    ..Experimental data support the conclusion that cutaneous chytridiomycosis is a fatal disease of anurans, and we hypothesize that it is the proximate cause of these recent amphibian declines...
  4. ncbi Diagnostic assays and sampling protocols for the detection of Batrachochytrium dendrobatidis
    A D Hyatt
    Australian Animal Health Laboratory, CSIRO Livestock Industries, Private Bag 24, Geelong, Victoria 3220, Australia
    Dis Aquat Organ 73:175-92. 2007
    ....
  5. ncbi Global emergence of Batrachochytrium dendrobatidis and amphibian chytridiomycosis in space, time, and host
    Matthew C Fisher
    Department of Infectious Disease Epidemiology, St Mary s Hospital, Imperial College, London W2 1PG, United
    Annu Rev Microbiol 63:291-310. 2009
    ..We then consider the major host and pathogen factors that have led to the occurrence of chytridiomycosis in amphibian species, populations, and communities...
  6. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
  7. pmc Emerging infectious disease and the loss of biodiversity in a Neotropical amphibian community
    Karen R Lips
    Department of Zoology, Southern Illinois University, Carbondale, 62901 6501, USA
    Proc Natl Acad Sci U S A 103:3165-70. 2006
    ..The high virulence and large number of potential hosts of this emerging infectious disease threaten global amphibian diversity...
  8. pmc Randomized, double-blind trial of fluconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantation
    John R Wingard
    University of Florida, Gainesville, FL, USA
    Blood 116:5111-8. 2010
    ..This trial was registered at www.clinicaltrials.gov as NCT00075803...
  9. ncbi Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia
    Oliver A Cornely
    University of Cologne, Cologne, Germany
    N Engl J Med 356:348-59. 2007
    ..Patients with neutropenia resulting from chemotherapy for acute myelogenous leukemia or the myelodysplastic syndrome are at high risk for difficult-to-treat and often fatal invasive fungal infections...
  10. ncbi The ecology and impact of chytridiomycosis: an emerging disease of amphibians
    A Marm Kilpatrick
    Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064, USA
    Trends Ecol Evol 25:109-18. 2010
    ..Chytridiomycosis is an archetypal emerging disease, with a broad host range and significant impacts on host populations and, as such, poses a crucial challenge for wildlife managers and an urgent conservation concern...
  11. ncbi Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease
    Andrew J Ullmann
    Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 356:335-47. 2007
    ..Invasive fungal infections are an important cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation...
  12. pmc Dynamics of an emerging disease drive large-scale amphibian population extinctions
    Vance T Vredenburg
    Department of Biology, San Francisco State University, San Francisco, CA 94132 1722, USA
    Proc Natl Acad Sci U S A 107:9689-94. 2010
    ..Preventing infection intensities in host populations from reaching this threshold could provide an effective strategy to avoid the extinction of susceptible amphibian species in the wild...
  13. ncbi Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:909-17. 2002
    ....
  14. pmc Survival of Batrachochytrium dendrobatidis in water: quarantine and disease control implications
    Megan L Johnson
    James Cook University, Townsville, Australia
    Emerg Infect Dis 9:922-5. 2003
    ..The knowledge that water can remain infective for up to 7 weeks is important for the formulation of disease control and quarantine strategies for the management of water that has been in contact with amphibians...
  15. pmc Pan-European distribution of white-nose syndrome fungus (Geomyces destructans) not associated with mass mortality
    Sebastien J Puechmaille
    School of Biology and Environmental Science, University College Dublin, Dublin, Ireland
    PLoS ONE 6:e19167. 2011
    ..Recent investigations in Europe confirmed the presence of the fungus G. destructans without associated mass mortality in hibernating bats in six countries but its distribution remains poorly known...
  16. ncbi Invasive mycoses: diagnostic challenges
    Luis Ostrosky-Zeichner
    Department of Medicine, University of Texas Health Medical School, Houston, Texas 77030, USA
    Am J Med 125:S14-24. 2012
    ....
  17. pmc Emerging infectious diseases and amphibian population declines
    P Daszak
    Institute of Ecology, University of Georgia, Athens, GA 30602, USA
    Emerg Infect Dis 5:735-48. 1999
    ..Finally, we discuss emerging infectious diseases as a global threat to wildlife populations...
  18. pmc Origin of the amphibian chytrid fungus
    Ché Weldon
    North West University, Potchefstroom, South Africa
    Emerg Infect Dis 10:2100-5. 2004
    ..We propose that Africa is the origin of the amphibian chytrid and that the international trade in X. laevis that began in the mid-1930s was the means of dissemination...
  19. ncbi European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3--2009 update
    J Maertens
    Department of Hematology, Leukemia and Stem Cell Transplantation Unit, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium
    Bone Marrow Transplant 46:709-18. 2011
    ....
  20. pmc Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Clin Invest 121:554-68. 2011
    ..Further, vaccine-induced Th17 cells were necessary and sufficient to protect against the three major systemic mycoses in North America...
  21. pmc Expression profiling the temperature-dependent amphibian response to infection by Batrachochytrium dendrobatidis
    Laia Ribas
    Department of Infectious Disease Epidemiology, Imperial College London, UK
    PLoS ONE 4:e8408. 2009
    ..This study demonstrates the temperature-dependency of the amphibian response to infection by Bd and indicates the influence that changing climates may exert on the ectothermic host response to pathogens...
  22. ncbi The damage-response framework of microbial pathogenesis
    Arturo Casadevall
    Departments of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Rev Microbiol 1:17-24. 2003
    ..To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework...
  23. ncbi Interactions between Batrachochytrium dendrobatidis and its amphibian hosts: a review of pathogenesis and immunity
    Jamie Voyles
    School of Public Health, Tropical Medicine and Rehabilitation Sciences, Amphibian Disease Ecology Group, James Cook University, Townsville, Queensland 4811, Australia
    Microbes Infect 13:25-32. 2011
    ..This review provides a summary of host characteristics, pathogen characteristics and host-pathogen responses to infection that are important for understanding disease development...
  24. pmc Wing pathology of white-nose syndrome in bats suggests life-threatening disruption of physiology
    Paul M Cryan
    United States Geological Survey, Fort Collins Science Center, Fort Collins, CO 80526, USA
    BMC Biol 8:135. 2010
    ..Mechanisms of disease associated with G. destructans seem specific to hibernating bats and are most analogous to disease caused by chytrid fungus in amphibians...
  25. pmc Rapid identification of fungi by using the ITS2 genetic region and an automated fluorescent capillary electrophoresis system
    C Y Turenne
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada
    J Clin Microbiol 37:1846-51. 1999
    ..We have found that most clinically significant fungal isolates can be differentiated by this method, and it therefore serves to be a promising tool for the rapid (<7 h) diagnosis of fungemia and other invasive fungal infections...
  26. ncbi Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006
    Marli Prado
    Departamento de Epidemiologia, Escola de Saúde Pública, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 104:513-21. 2009
    Deaths caused by systemic mycoses such as paracoccidioidomycosis, cryptococcosis, histoplasmosis, candidiasis, aspergillosis, coccidioidomycosis and zygomycosis amounted to 3,583 between 1996-2006 in Brazil...
  27. pmc Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevis
    Jeremy P Ramsey
    Department of Microbiology and Immunology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Infect Immun 78:3981-92. 2010
    ..dendrobatidis. These data strongly suggest that both innate and adaptive immune defenses are involved in the resistance of X. laevis to lethal B. dendrobatidis infections...
  28. pmc Enzootic and epizootic dynamics of the chytrid fungal pathogen of amphibians
    Cheryl J Briggs
    Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 107:9695-700. 2010
    ..The model also shows that persistence of Bd is enhanced by the long-lived tadpole stage that characterize these two frog species, and by nonhost Bd reservoirs...
  29. ncbi TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
    Carole Couillault
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France
    Nat Immunol 5:488-94. 2004
    ..As the activity of tir-1 was independent of the single nematode Toll-like receptor, TIR-1 may represent a component of a previously uncharacterized, but conserved, innate immune signaling pathway...
  30. ncbi Fungal LysM effectors: extinguishers of host immunity?
    Ronnie de Jonge
    Laboratory of Phytopathology, Wageningen University, 6709 PD Wageningen, The Netherlands
    Trends Microbiol 17:151-7. 2009
    ....
  31. ncbi Varying responses of northeastern North American amphibians to the chytrid pathogen Batrachochytrium dendrobatidis
    Megan K Gahl
    Department of Biology, Canadian Rivers Institute, University of New Brunswick, P O Box 5050, St John, New Brunswick, E2L 4L5, Canada
    Conserv Biol 26:135-41. 2012
    ....
  32. ncbi Reptiles as potential vectors and hosts of the amphibian pathogen Batrachochytrium dendrobatidis in Panama
    Vanessa L Kilburn
    Department of Biology, McGill University, 1205 Docteur Penfield Ave, Montreal, Quebec H3A 1B1, Canada
    Dis Aquat Organ 97:127-34. 2011
    ..Our study is the first to provide evidence of non-amphibian carriers for B. dendrobatidis in a natural Neotropical environment...
  33. pmc Genomic transition to pathogenicity in chytrid fungi
    Suzanne Joneson
    Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America
    PLoS Pathog 7:e1002338. 2011
    ..Finally, we demonstrate that the timing of the protease gene family expansions predates the emergence of Bd as a globally important amphibian pathogen...
  34. ncbi Batrachochytrium dendrobatidis infection patterns among Panamanian amphibian species, habitats and elevations during epizootic and enzootic stages
    Forrest M R Brem
    Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901 6501, USA
    Dis Aquat Organ 81:189-202. 2008
    ..Variation among species, microenvironmental conditions, and the length of coexistence with Bd may contribute to observed differences in prevalence of Bd and in population response...
  35. pmc Rapid global expansion of the fungal disease chytridiomycosis into declining and healthy amphibian populations
    Timothy Y James
    Department of Biology, Duke University, Durham, NC, USA
    PLoS Pathog 5:e1000458. 2009
    ..The widespread occurrence of the same lineage in both healthy and declining populations suggests that the outcome of the disease is contingent on environmental factors and host resistance...
  36. pmc Specific alterations in complement protein activity of little brown myotis (Myotis lucifugus) hibernating in white-nose syndrome affected sites
    Marianne S Moore
    Department of Biology, Center for Ecology and Conservation Biology, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 6:e27430. 2011
    ..Relationships between immune activity and torpor, including associated energy expenditure, are likely critical components in the development of WNS...
  37. ncbi Immune reconstitution syndrome associated with opportunistic mycoses
    Nina Singh
    Infectious Disease Section, VA Medical Center, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Lancet Infect Dis 7:395-401. 2007
    ....
  38. ncbi Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis
    Eyal Robenshtok
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    J Clin Oncol 25:5471-89. 2007
    ..Many studies have evaluated the role of antifungal prophylaxis in cancer patients, with inconsistent conclusions...
  39. ncbi Management of mycoses in surgical patients -- review of the literature
    Rene G Holzheimer
    Department of Surgery, Martin Luther University, Halle Wittenberg, Germany
    Eur J Med Res 7:200-26. 2002
    ..Newer azoles, e.g. voriconazole, demonstrated stable activity against most of these strains and may offer an option in the treatment of refractory fungal infections...
  40. ncbi Survey protocol for detecting chytridiomycosis in all Australian frog populations
    Lee F Skerratt
    Amphibian Disease Ecology Group, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 80:85-94. 2008
    ..This protocol can be adapted for use in other countries and a standard protocol will enable comparison among amphibian populations globally...
  41. pmc The emerging amphibian pathogen Batrachochytrium dendrobatidis globally infects introduced populations of the North American bullfrog, Rana catesbeiana
    Trenton W J Garner
    Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, UK
    Biol Lett 2:455-9. 2006
    ..These factors taken together with our study suggest that the global threat of B. dendrobatidis disease transmission posed by bullfrogs is significant...
  42. pmc Genome-wide transcriptional response of Silurana (Xenopus) tropicalis to infection with the deadly chytrid fungus
    Erica Bree Rosenblum
    Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America
    PLoS ONE 4:e6494. 2009
    ..This study generates important baseline data for ongoing efforts to understand differences in response to Bd between susceptible and resistant frog species and the effects of chytridiomycosis in natural populations...
  43. ncbi Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever
    Thomas J Walsh
    National Cancer Institute, Bethesda, MD 20892, USA
    N Engl J Med 346:225-34. 2002
    ..Patients with neutropenia and persistent fever are often treated empirically with amphotericin B or liposomal amphotericin B to prevent invasive fungal infections. Antifungal triazoles offer a potentially safer and effective alternative...
  44. ncbi Electrolyte depletion and osmotic imbalance in amphibians with chytridiomycosis
    Jamie Voyles
    Amphibian Disease Ecology Group, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 77:113-8. 2007
    ..dendrobatidis. Understanding the mechanisms of mortality may also explain interspecific variation in susceptibility to chytridiomycosis...
  45. ncbi Life cycle stages of the amphibian chytrid Batrachochytrium dendrobatidis
    Lee Berger
    Amphibian Disease Ecology Group, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 68:51-63. 2005
    ..Hyperkeratosis may be due to (1) a hyperplastic response that leads to an increased turnover of epidermal cells, and (2) premature keratinization and death of infected cells...
  46. ncbi Virulence of the amphibian chytrid fungus Batrachochytium dendrobatidis varies with the strain
    Lee Berger
    Amphibian Disease Ecology Group, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 68:47-50. 2005
    ..A standard naming scheme for isolates of B. dendrobatidis is proposed...
  47. pmc Cutaneous bacteria of the redback salamander prevent morbidity associated with a lethal disease
    Matthew H Becker
    Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA
    PLoS ONE 5:e10957. 2010
    ..Therefore, symbiotic microbes associated with this species appear to be an important component of its innate skin defenses...
  48. ncbi Amphibian chytridiomycosis in Japan: distribution, haplotypes and possible route of entry into Japan
    Koichi Goka
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Mol Ecol 18:4757-74. 2009
    ..To improve chytridiomycosis risk management, we must consider the risk of B. dendrobatidis changing hosts as a result of anthropogenic disturbance of the host-specific distribution of the fungus...
  49. ncbi Addition of antifungal skin bacteria to salamanders ameliorates the effects of chytridiomycosis
    Reid N Harris
    Department of Biology, James Madison University, Harrisonburg, Virginia 22807, USA
    Dis Aquat Organ 83:11-6. 2009
    ..Our results also suggest a mechanism for the association of climate change and the likelihood of chytridiomycosis outbreaks via the effects of the former on antifungal bacterial communities...
  50. ncbi Chemotaxis of the amphibian pathogen Batrachochytrium dendrobatidis and its response to a variety of attractants
    Angela S Moss
    Department of Biological Sciences, Box 43131, Texas Tech University, Lubbock, Texas 79409 3131, USA
    Mycologia 100:1-5. 2008
    ..These observations suggest that the chytrid can respond to nutritional cues, including those of host origin. Implications of these observations to amphibian susceptibility to infection and chytrid virulence are discussed...
  51. ncbi Distribution of Batrachochytrium dendrobatidis and pathology in the skin of green tree frogs Litoria caerulea with severe chytridiomycosis
    Lee Berger
    Amphibian Disease Ecology Group, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 68:65-70. 2005
    ..In some frogs, ulceration and erosions occurred on skin on the back in the absence of sporangia. Other pathological changes such as hyperkeratosis and congestion occurred much more frequently on ventral surfaces...
  52. pmc Morphological and molecular characterizations of psychrophilic fungus Geomyces destructans from New York bats with White Nose Syndrome (WNS)
    Vishnu Chaturvedi
    Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA
    PLoS ONE 5:e10783. 2010
    ..The fungus has been recovered sparsely despite plentiful availability of afflicted animals...
  53. ncbi Batrachochytrium dendrobatidis can infect and cause mortality in the nematode Caenorhabditis elegans
    E J Shapard
    Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409 3131, USA
    Mycopathologia 173:121-6. 2012
    ..These observations suggest that C. elegans may be a useful model organism to study the pathogenicity and virulence mechanisms of Bd...
  54. pmc Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006
    Benjamin J Park
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:1855-64. 2011
    ..Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period...
  55. ncbi Empirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial
    Catherine Cordonnier
    Hematology Department, Henri Mondor Teaching Hospital, Assistance Publique Hôpitaux de Paris AP HP and Paris 12 University, Creteil, France
    Clin Infect Dis 48:1042-51. 2009
    ..Recent diagnostic improvements may ensure the early diagnosis of potentially invasive fungal disease. Reserving antifungals for this stage may achieve similar survival rates and reduce treatment toxicity and costs...
  56. pmc Immunity to fungi
    Salome Leibundgut-Landmann
    Institute of Microbiology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    Curr Opin Immunol 24:449-58. 2012
    ..These advances form a basis for the development of fungal vaccines and immune-based therapeutic adjuncts...
  57. ncbi Invasive mycoses: strategies for effective management
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Med 125:S25-38. 2012
    ..This article discusses strategies for the effective management of invasive mycoses, with a particular focus on antifungal hepatotoxicity.
  58. ncbi Sociality, density-dependence and microclimates determine the persistence of populations suffering from a novel fungal disease, white-nose syndrome
    Kate E Langwig
    Center for Ecology and Conservation Biology, Department of Biology, Boston University, Boston, MA 02215, USA
    Ecol Lett 15:1050-7. 2012
    ..These results expand our theoretical framework and provide an empirical basis for determining which host species are likely to be driven extinct while management action is still possible...
  59. ncbi Impact of alternate definitions of fever resolution on the composite endpoint in clinical trials of empirical antifungal therapy for neutropenic patients with persistent fever: analysis of results from the Caspofungin Empirical Therapy Study
    B E de Pauw
    University Hospital St Radboud, Nijmegen, The Netherlands
    Transpl Infect Dis 8:31-7. 2006
    ..liposomal amphotericin B as empirical antifungal therapy for febrile neutropenic patients to determine the impact of varying definitions of fever resolution on response rates...
  60. ncbi DNA-based detection of the fungal pathogen Geomyces destructans in soils from bat hibernacula
    Daniel L Lindner
    US Forest Service, Northern Research Station, Center for Forest Mycology Research, One Gifford Pinchot Drive, Madison, Wisconsin 53726, USA
    Mycologia 103:241-6. 2011
    ..in soil from bat hibernacula and indicates that further research is needed to better define the taxonomy of this genus and to develop enhanced diagnostic tests for rapid and specific detection of G. destructans in environmental samples...
  61. ncbi Immunization is ineffective at preventing infection and mortality due to the amphibian chytrid fungus Batrachochytrium dendrobatidis
    Mary J Stice
    Department of Integrative Biology, University of California Berkeley, 3060 VLSB MC3140, Berkeley, California 94720, USA
    J Wildl Dis 46:70-7. 2010
    ....
  62. ncbi Cost efficiency in the detection of chytridiomycosis using PCR assay
    Kerry M Kriger
    Griffith University, Centre for Innovative Conservation Strategies, Queensland, Australia
    Dis Aquat Organ 71:149-54. 2006
    ..We recommend that amphibian disease researchers adopt the singlicate qPCR assay as the primary means of chytridiomycosis detection...
  63. ncbi First survey for the amphibian chytrid fungus Batrachochytrium dendrobatidis in Connecticut (USA) finds widespread prevalence
    Kathryn L Richards-Hrdlicka
    School of Forestry and Environmental Studies, Yale University, New Haven, CT 06511, USA
    Dis Aquat Organ 102:169-80. 2013
    ....
  64. pmc The bacterially produced metabolite violacein is associated with survival of amphibians infected with a lethal fungus
    Matthew H Becker
    Department of Biological Sciences, Virginia Tech, MC 0406, Blacksburg, VA 24061, USA
    Appl Environ Microbiol 75:6635-8. 2009
    ..cinereus and that adding J. lividum is effective for protecting individuals that lack violacein-producing skin bacteria...
  65. ncbi Immune reconstitution syndrome and fungal infections
    Ashish O Gupta
    Division of Hematology and Oncology, Children s Hospital of University of Pittsburgh, Pennsylvania, USA
    Curr Opin Infect Dis 24:527-33. 2011
    ..This review summarizes the current state of knowledge regarding its pathophysiologic basis, presentation, and treatment strategies...
  66. pmc Posaconazole exposure-response relationship: evaluating the utility of therapeutic drug monitoring
    Michael J Dolton
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Antimicrob Agents Chemother 56:2806-13. 2012
    ..In patients with subtherapeutic posaconazole concentrations, increased dose frequency, administration with high-fat meals, and withdrawal of interacting medications from therapy are useful strategies to improve systemic absorption...
  67. ncbi International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia
    Thomas Lehrnbecher
    Paediatric Haematology and Oncology, University of Frankfurt, Frankfurt, Germany
    Br J Haematol 147:125-8. 2009
    ..0%, P = 0.03). There were systematic differences in infection-related supportive care practices. This information may be used to encourage harmonization of supportive care practices and future randomized trials...
  68. ncbi BSA reduces inhibition in a TaqMan assay for the detection of Batrachochytrium dendrobatidis
    Stephen Garland
    Amphibian Disease Ecology Group, James Cook University, and the School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 92:113-6. 2010
    ..We recommend the addition of 400 ng microl(-1) of BSA to the standard TaqMan assay to reduce inhibition associated with sampling wild amphibians...
  69. pmc Combination antifungal therapy
    Melissa D Johnson
    Departments of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 48:693-715. 2004
  70. pmc Adaptive immunity to fungi
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Annu Rev Immunol 30:115-48. 2012
    ..Also emphasized is how the latter deploy effector and regulatory mechanisms that eliminate these nasty invaders while also constraining collateral damage to vital tissue...
  71. pmc Identification of Paecilomyces variotii in clinical samples and settings
    Jos Houbraken
    CBS KNAW Fungal Biodiversity Centre, Department of Applied and Industrial Mycology, Utrecht 3584 CT, Netherlands
    J Clin Microbiol 48:2754-61. 2010
    ..also associated with many types of human infections and is among the emerging causative agents of opportunistic mycoses in immunocompromised hosts...
  72. ncbi Fatal chytridiomycosis in the tyrrhenian painted frog
    Jon Bielby
    Institute of Zoology, Zoological Society of London, Regent s Park, London, UK
    Ecohealth 6:27-32. 2009
    ....
  73. ncbi Epidemiology of opportunistic fungal infections in Latin America
    Marcio Nucci
    Department of Internal Medicine, Hematology Unit and Mycology Laboratory, University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Clin Infect Dis 51:561-70. 2010
    ..The epidemiologic features, including incidence, of some of these mycoses are markedly different in Latin America than they are in other parts of the world...
  74. ncbi Vertebrate endothermy restricts most fungi as potential pathogens
    Vincent A Robert
    Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands
    J Infect Dis 200:1623-6. 2009
    ..Mammalian endothermy and homeothermy are potent nonspecific defenses against most fungi that could have provided a strong evolutionary survival advantage against fungal diseases...
  75. ncbi The immune response to fungal infections
    Shmuel Shoham
    Section of Infectious Diseases, Washington Hospital Center, Washington, DC, USA
    Br J Haematol 129:569-82. 2005
    ..An understanding of the host response to these organisms is important in decisions regarding use of currently available antifungal therapies and in the design of new therapeutic modalities...
  76. ncbi Widespread occurrence of the amphibian chytrid fungus Batrachochytrium dendrobatidis in the southeastern USA
    Betsie B Rothermel
    Austin Peay State University, The Center of Excellence for Field Biology, PO Box 4718, Clarksville, Tennessee 37044, USA
    Dis Aquat Organ 82:3-18. 2008
    ..Although presence-absence surveys may still be needed for some taxa, such as bufonids, we recommend that future researchers focus on potential population-level effects at sites where Bd is now known to occur...
  77. ncbi Hospitalizations for endemic mycoses: a population-based national study
    Jaclyn H Chu
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Infect Dis 42:822-5. 2006
    ..Sample, a national database of hospital inpatient stays, to describe the incidence and epidemiology of endemic mycoses requiring hospitalization...
  78. ncbi Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment: a 13-year experience at a single Italian institution
    Elio Castagnola
    Infectious Diseases Unit, Department of Hematology Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Eur J Cancer 41:1439-45. 2005
    The incidence rate (IR) of bloodstream infections (BI) and invasive mycoses (IM) during chemotherapy for paediatric acute lymphoblastic (ALL) or non-lymphoblastic leukaemias (AnLL) was evaluated for 153 BI and 22 IM diagnosed during 143,..
  79. ncbi Fluconazole versus itraconazole for antifungal prophylaxis in neutropenic patients with haematological malignancies: a meta-analysis of randomised-controlled trials
    Konstantinos Z Vardakas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Br J Haematol 131:22-8. 2005
    ....
  80. ncbi Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning
    Takahiro Fukuda
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 102:827-33. 2003
    ..More effective strategies are needed to prevent invasive mold infections, which currently account for a notable proportion of nonrelapse mortality after nonmyeloablative allogeneic HCT...
  81. pmc Population genetics of the frog-killing fungus Batrachochytrium dendrobatidis
    Jess A T Morgan
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:13845-50. 2007
    ..Recombination raises the possibility of resistant sporangia and a mechanism for rapid spread as well as persistence that could greatly complicate global control of the pathogen...
  82. pmc Primary prophylaxis of invasive fungal infections in patients with hematologic malignancies. Recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology
    Oliver A Cornely
    Klinikum der Universität zu Köln, Klinik I für Innere Medizin Zentrum für Klinische Studien BMBF 01KN0706, Koln, Germany
    Haematologica 94:113-22. 2009
    ..Fluconazole 400 mg/d is recommended in allogeneic stem cell recipients until development of graft versus host disease only (Level A I). Aerosolized liposomal amphotericin B is recommended during prolonged neutropenia (Level B II)...
  83. ncbi Infections caused by filamentous fungi in patients with hematologic malignancies. A report of 391 cases by GIMEMA Infection Program
    L Pagano
    Istituto di Semeiotica Medica, Universita Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
    Haematologica 86:862-70. 2001
    ..To evaluate the clinical characteristics of patients with hematologic malignancies developing a filamentous fungi infection (FFI) and to define the prognostic factors for their outcome...
  84. ncbi An insight into the antifungal pipeline: selected new molecules and beyond
    Luis Ostrosky-Zeichner
    Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin, MSB 2 112, Houston, Texas 77030, USA
    Nat Rev Drug Discov 9:719-27. 2010
    ..Few therapeutic products are currently in active development, and progression of therapeutic agents with fungus-specific mechanisms of action is of key importance...
  85. ncbi Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
    Nat Immunol 10:203-13. 2009
    ..Thus, dectin-1 activates two independent signaling pathways, one through Syk and one through Raf-1, to induce immune responses...
  86. pmc Seasonal pattern of Batrachochytrium dendrobatidis infection and mortality in Lithobates areolatus: affirmation of Vredenburg's "10,000 zoospore rule"
    Vanessa C Kinney
    Department of Biology, Indiana State University, Terre Haute, Indiana, United States of America
    PLoS ONE 6:e16708. 2011
    ..Bd-negative postmetamorphic juveniles may not be exposed again to this pathogen until they take up residence in crayfish burrows, or until their first breeding, some years later...
  87. ncbi Effects of temperature and hydric environment on survival of the Panamanian Golden Frog infected with a pathogenic chytrid fungus
    Heidi M Bustamante
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    Integr Zool 5:143-53. 2010
    ....
  88. ncbi Transmission of Batrachochytrium dendrobatidis within and between amphibian life stages
    Lara J Rachowicz
    Department of Integrative Biology, University of California, Berkeley, California 94720 3140, USA
    Dis Aquat Organ 61:75-83. 2004
    ..In addition, we provide guidelines for visually detecting B. dendrobatidis in R. muscosa tadpoles, which may be useful in other affected species. Field surveys of infected and uninfected populations verify this identification technique...
  89. ncbi Latitudinal variation in the prevalence and intensity of chytrid (Batrachochytrium dendrobatidis) infection in eastern Australia
    Kerry M Kriger
    Griffith University, Centre for Innovative Conservation Strategies, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Conserv Biol 21:1280-90. 2007
    ..Our results will directly assist amphibian disease researchers and wildlife managers, whose conservation efforts should focus on those amphibian populations living within the B. dendrobatidis climatic envelope that we have described...
  90. ncbi Recognition of fungal pathogens by toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, and Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Curr Pharm Des 12:4195-201. 2006
    ..These recent developments provide crucial information for understanding the mechanisms of fungal recognition by cells of the immune system, and provide hope for designing new therapeutical approaches to fungal infections...
  91. ncbi Incidence and predictive factors for infectious disease after rituximab therapy in kidney-transplant patients
    N Kamar
    Department of Nephrology, Dialysis and Multi Organ Transplantation, INSERM U858, CHU Rangueil, Toulouse, France
    Am J Transplant 10:89-98. 2010
    ..After kidney transplantation, the use of rituximab is associated with a high risk of infectious disease and death related to infectious disease...
  92. pmc High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections
    Lixin Zhang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Proc Natl Acad Sci U S A 104:4606-11. 2007
    ..Such an effect was not achieved even with the high dose of 50 mg/kg KTC. These data support synergism between BEA and KTC and thereby a prospective strategy for antifungal therapy...
  93. ncbi Impacts of Batrachochytrium dendrobatidis infection on tadpole foraging performance
    Matthew D Venesky
    Department of Biology, University of Memphis, Memphis, TN 38152, USA
    Ecohealth 6:565-75. 2009
    ..Thus, our results provide a potential mechanism of decreased developmental rates of Bd-infected tadpoles...
  94. ncbi Disseminated Penicillium marneffei infection among HIV-infected patients in Manipur state, India
    K H Ranjana
    Department of Microbiology, J N Medical Hospital, Imphal 795001, Manipur, India
    J Infect 45:268-71. 2002
    ..To further describe the clinical and epidemiological characteristics of Penicillium marneffei infection in human immunodeficiency virus (HIV) infected patients in India...
  95. ncbi Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes
    Andres Pascual
    Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 46:201-11. 2008
    ..Liver disease, age, genetic polymorphism of the cytochrome CYP2C19, and comedications influence voriconazole metabolism. Large variations in voriconazole pharmacokinetics may be associated with decreased efficacy or with toxicity...
  96. ncbi Seasonality of Batrachochytrium dendrobatidis infection in direct-developing frogs suggests a mechanism for persistence
    Ana V Longo
    Department of Biology, University of Puerto Rico, PO Box 23360, San Juan, Puerto Rico 00931 3360
    Dis Aquat Organ 92:253-60. 2010
    ..Our data suggest a mechanism by which this disease can persist in tropical frog communities without decimation of its hosts, but that complex interactions during severe droughts may lead to population crashes...
  97. ncbi Quantifying the disease transmission function: effects of density on Batrachochytrium dendrobatidis transmission in the mountain yellow-legged frog Rana muscosa
    Lara J Rachowicz
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Anim Ecol 76:711-21. 2007
    ..5. The impacts of crowding and temperature on transmission were also investigated; however, neither of these factors significantly affected the transmission rate...
  98. ncbi The changing face of epidemiology of invasive fungal disease in Europe
    Cornelia Lass-Flörl
    Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Mycoses 52:197-205. 2009
    ..Choice between agents should be based on a variety of factors, including spectrum of activity, adverse events, drug interactions, route of administration, clinical efficacy of individual agents and local epidemiology...
  99. ncbi Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner
    Vaibhav B Shah
    Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    J Immunol 180:2777-85. 2008
    ..Our results suggest that the Dectin-1 pathway may play an important role in antifungal immunity in the CNS...
  100. pmc Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus
    M A Pfaller
    Department of Pathology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 42:4419-31. 2004
  101. ncbi Exogenous fungal endophthalmitis: microbiology and clinical outcomes
    Charles C Wykoff
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmology 115:1501-7, 1507.e1-2. 2008
    ..To report the fungal isolates, treatment strategies, and clinical outcomes for a large series of patients with exogenous fungal endophthalmitis...

Research Grants62

  1. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..an exploratory project to create peptide MHC II tetramers that will advance insight into the immunity to endemic mycoses and the biology of long-lived memory among IL-17 producing CD4+ T cells...
  2. Prospective Cohort Study of Cryptococcosis
    PETER RICHARD WILLIAMSON; Fiscal Year: 2013
    ..cohort study, employing an internet-based case report form in an established network of sites led by the global Mycoses Study Group, with site identification facilitated by national and state public health officials...
  3. Interactions of pDCs with Aspergilus
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..Moreover, the knowledge gained may lead to novel strategies to prevent and treat invasive mycoses.
  4. Screen for phosphatidylserine synthase inhibitors: antifungals &lipid probes
    Todd B Reynolds; Fiscal Year: 2013
    ..molecules: There is a need for new antifungals, as there are only 3 classes of these drugs used to treat invasive mycoses, and a combination of toxicity, drug resistance, and poor oral availability limit their effectiveness...
  5. Dissection of Macrophage Antifungal Activity against Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Airborne conidia (spores) represent infectious propagules that are responsible for transmission of major human mycoses. Humans inhale ubiquitous Aspergillus fumigatus conidia on a daily basis...
  6. The link between dimorphism and virulence in Cryptococcus
    Xiaorong Lin; Fiscal Year: 2013
    ..goals are to understand the fundamental requirements for morphogenesis and pathogenicity that are common to fungal pathogens, and to harness such knowledge to develop preventative and therapeutic measures against invasive mycoses.
  7. Molecular and chemical validation of the vacuole as a new antifungal agent
    Glen Palmer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In recent decades, there has been a dramatic increase in invasive mycoses, including life-threatening disseminated as well as debilitating mucosal infections...
  8. A New Class of Broad Spectrum Antifungal Agents
    Glen Palmer; Fiscal Year: 2013
    ..of a diverse range of fungal infections, including those of mucosal tissues and life threatening disseminated mycoses. The opportunist Candida albicans is a leading cause of both types of infection...
  9. Antifungal Drug Susceptibility of Cryptococcus neoformans
    Robert Larsen; Fiscal Year: 2009
    ..B alone or combined with fluconazole in the treatment of AIDS-associated cryptococcal meningitis: (Bacterial and Mycoses Study Group: BAMSG 3-01)...
  10. New methods for the early diagnosis of invasive fungal infections
    Maurizio Del Poeta; Fiscal Year: 2009
    ..Ultimately, these tools will significantly help in the management of invasive mycoses. In recent years, our laboratory has centered on dissecting molecular mechanisms of fungal pathogenesis, focusing ..
  11. B DERMATITIDIS CONIDIAL-MACROPHAGE INTERACTIONS
    Stephen Moser; Fiscal Year: 1993
    The systemic mycoses are important human pathogens responsible for severe pulmonary and disseminated infections...
  12. MOLECULAR IDENTIFICATION OF PATHOGENIC FUNGI
    Thomas Mitchell; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): In recent years, the incidence of life threatening mycoses and the range of fungal species causing these infection have been increasing globally...
  13. MOLECULAR PATHOGENESIS OF PULMONARY HISTOPLASMOSIS
    JON WOODS; Fiscal Year: 2004
    ..Histoplasmosis is the most common endemic mycoses in the world and is particularly dangerous for immunocompromised patients...
  14. ANTIMICROBIAL THERAPY OF SYSTEMIC MYCOTIC DISEASES
    William Dismukes; Fiscal Year: 1990
    The NIAID multicenter Mycoses Study Group has designed multiple Phase I, II, and III clinical studies to evaluate the efficacy and toxicity of various single and multiple drug regimens for the therapy of cryptococcal meningitis and ..
  15. MUCOSAL IMMUNIZATION--PREVENTION OF SYSTEMIC CANDIDIASIS
    LUCY FREYTAG; Fiscal Year: 2003
    ..Currently, there are no vaccines against human mycoses, and a vaccine capable of stimulating immunity in selected patients prior to immunosuppression would be of ..
  16. Antifungal sphingolipids for AIDS-related Mycoses
    TADEUSZ MOLINSKI; Fiscal Year: 2005
    ..Lead compounds will be selected for advanced in vivo evaluation in murine models of fungemia. ..
  17. A TARGETED AMPHOTERICIN B PRODRUG FOR ANTIFUNGAL THERAPY
    SEAN O MALLEY; Fiscal Year: 2000
    ..of the proposed phase II research is to demonstrate a completely novel approach to the treatment of disseminated mycoses and a new application of the concept of antibody-directed activation of prodrugs, which has previously been ..
  18. A NOVEL ANTIFUNGAL COMPOUND FROM CAYENNE PEPPER
    Claude Selitrennikoff; Fiscal Year: 2001
    DESCRIPTION (Adapted from the application): Deep-seated mycoses are being increasingly observed in immunocompromised patients and in patients receiving aggressive cancer chemotherapy...
  19. DISCOVERY OF NOVEL FUNGICIDAL AGENTS
    LESTER MITSCHER; Fiscal Year: 1992
    Due to the recognized increase in systemic mycoses and the deleterious side effects exhibited by current anti- fungal chemotherapy, there has been an increasing need for new agents with good pharmacokinetics and lower toxicity...
  20. Drug Delivery System for Superficial Mycoses
    NANCY GIRARD; Fiscal Year: 2002
    ..drug delivery system for use as a sustained-release, antifungal skin preparation for the treatment of superficial mycoses. The lifetime risk of acquiring a superficial mycotic infection is estimated to be between 10 and 20 percent...
  21. SCREENING OF THERMOPHILES FOR ANTIFUNGAL ACTIVITY
    Claude Selitrennikoff; Fiscal Year: 2000
    Deep-seated mycoses are being increasingly observed in immunocompromised patients and in patients receiving aggressive cancer chemotherapy...
  22. Prevention/diagnosis/fungal infections/transplantation
    Barbara Alexander; Fiscal Year: 2005
    ..Similarly, if an assay could be developed that would reliably diagnose invasive mycoses early in the course of infection, targeted antifungal regimens could be started at a stage of infection more ..
  23. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005
    ..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
  24. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
    ..For human mycoses the difficulties in using standard genetic approaches are compounded by the fact that many types of fungal ..
  25. Detection and Significance of Antifungal Resistance in Oropharyngeal Candidiasis
    Thomas F Patterson; Fiscal Year: 2010
    ..This research is aimed at developing rapid molecular tests to detect yeasts which are resistant to antifungal agents in order to allow early use of more effective therapy. ..
  26. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  27. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
  28. Transplant Associated Infection Surveillance Network
    Peter Pappas; Fiscal Year: 2008
    ..Finally, the establishment of a bank will be invaluable in the development and validation of newer diagnostic assays. ..
  29. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  30. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  31. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  32. QUALITY OF LIFE AND RELATIONSHIPS AFTER BMT
    John Wingard; Fiscal Year: 2001
    ..This information is essential to subsequent planning and implementation of relevant, well-aimed interventions to minimize psychosocial disruption and enhance growth in future BMT recipients and their loved ones. ..
  33. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  34. CRYPTOCOCCUS NEOFORMANS--A MODEL FOR PATHOGENIC FUNGI
    John Perfect; Fiscal Year: 2003
    ..This program emphasizes a focus on a single pathogen with a basic but broad-spectrum and highly interactive genomic approach to scientific investigations which can be extrapolated to other fungi. ..
  35. GENETIC & MOLECULAR BIOLOGY OF VIRULENCE IN C NEOFORMANS
    John Perfect; Fiscal Year: 2004
    ..It is our hypothesis that beginning to understand the genetic regulation of C. neoformans during infection through this proposal will be a powerful tool to find targets to interrupt pathogenesis. ..
  36. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. Genetic Determinants of A. Fumigatus Susceptibility
    Aimee Zaas; Fiscal Year: 2008
    ..fumigatus infection, this proposal will identify and characterize genetic polymorphisms related to IA susceptibility in mice and validate these findings in a cohort of human bone marrow transplant donors and recipients. ..
  38. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
  39. RECENT ADVANCES IN AIDS AND HIV RESEARCH
    Michael Saag; Fiscal Year: 2007
    ..CME credit for attending physicians will be provided. ..
  40. ENERGY COUPLING BY THE YEAST PLASMA MEMBRANE H+_ATPASE
    David Perlin; Fiscal Year: 2004
    ..abstract_text> ..
  41. EXPERIMENTAL PATHOLOGY SHARED RESOURCE LABORATORY
    Laura Lamps; Fiscal Year: 2003
    ..abstract_text> ..
  42. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2004
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  43. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
  44. ADULT AIDS CLINICAL TRIALS UNIT
    Mitchell Goldman; Fiscal Year: 2008
    ..Specialized immunology, virology, and pharmacology laboratories will support this work. ..
  45. Aspergillus Angioinvasion and Dissemination
    Scott Filler; Fiscal Year: 2006
    ..These studies are designed to lay the essential foundation for a comprehensive research program aimed at elucidating the molecular mechanisms by which A. fumigatus invades blood vessels and hematogenously disseminates. ..
  46. ADULT AIDS CLINICAL TRIALS GROUP
    Michael Saag; Fiscal Year: 2007
    ..abstract_text> ..
  47. HIV/STD Network Prevention Trial in Northern Vietnam
    Vivian Go; Fiscal Year: 2005
    ....
  48. Genetic Diversity of A. fumigatus
    Kieren Marr; Fiscal Year: 2007
    ..and will develop a stringent molecular typing method that will enhance our knowledge of the biology and population structure of the fungal pathogen A. fumigatus. ..
  49. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  50. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  51. CANDIDA ALBICANS SURFACE ANTIGENS
    Jim Cutler; Fiscal Year: 2006
    ....
  52. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
    ..abstract_text> ..
  53. Modeling Sequential Antiretroviral Therapy in HIV
    Elena Losina; Fiscal Year: 2005
    ..This award will provide critical insight into the optimal strategies for managing HIV infection and will provide Dr. Losina with a solid foundation for development as an independent and productive investigator. ..
  54. MHC Restricted Immunotherapeutic Targets in AML
    Dean Lee; Fiscal Year: 2006
    ..I anticipate that this translational research could lead directly to clinical trials evaluating antigen specific active (vaccines) or passive (adoptive transfer) immunotherapy for AML. ..
  55. Knee OA: Setting Priorities for Care, Policy, Research
    Elena Losina; Fiscal Year: 2010
    ..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
  56. A tetR/tetO-regulated promoter system for A. fumigatus
    David Askew; Fiscal Year: 2003
    ..The ability to manipulate gene expression in vivo would provide a unique opportunity to assess the contribution of a specific A. fumigatus gene product to the pathogenesis of aspergillosis. ..
  57. High Purity Amphotericin B: A Safer Antimycotic in AIDS
    John Cleary; Fiscal Year: 2005
    ..clinical trial results will be used to support an NDA for seeking approval for the use of AmB HP in disseminated mycoses commonly seen in patients with HIV infections or other infections of immunocompromised patients.