wound infection

Summary

Summary: Invasion of the site of trauma by pathogenic microorganisms.

Top Publications

  1. pmc Burn wound infections
    Deirdre Church
    Calgary Laboratory Services, 9 3535 Research Rd N W, Calgary, Alberta, Canada T2L 2K8
    Clin Microbiol Rev 19:403-34. 2006
  2. pmc Wound microbiology and associated approaches to wound management
    P G Bowler
    ConvaTec Global Development Center, Deeside, Flintshire, United Kingdom
    Clin Microbiol Rev 14:244-69. 2001
  3. pmc Interactions of methicillin resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in polymicrobial wound infection
    Irena Pastar
    Department of Dermatology and Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e56846. 2013
  4. ncbi Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing
    Anandev N Gurjala
    Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Wound Repair Regen 19:400-10. 2011
  5. pmc An in vivo polymicrobial biofilm wound infection model to study interspecies interactions
    Trevor Dalton
    Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
    PLoS ONE 6:e27317. 2011
  6. pmc Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds
    Mustafa Fazli
    Department of International Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen N DK 2200, Denmark
    J Clin Microbiol 47:4084-9. 2009
  7. ncbi Chronic wound infection: facts and controversies
    Abdul R Siddiqui
    Medical Service, Department of Veterans Affairs Medical Center, Dayton, OH 45428, USA
    Clin Dermatol 28:519-26. 2010
  8. ncbi A prospective study of infections in burn patients
    Pia Appelgren
    Department of Infectious Diseases, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    Burns 28:39-46. 2002
  9. pmc Innate defense regulator peptide 1018 in wound healing and wound infection
    Lars Steinstraesser
    Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e39373. 2012
  10. ncbi Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds
    Mustafa Fazli
    Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Wound Repair Regen 19:387-91. 2011

Detail Information

Publications304 found, 100 shown here

  1. pmc Burn wound infections
    Deirdre Church
    Calgary Laboratory Services, 9 3535 Research Rd N W, Calgary, Alberta, Canada T2L 2K8
    Clin Microbiol Rev 19:403-34. 2006
    ..Early excision of the eschar has substantially decreased the incidence of invasive burn wound infection and secondary sepsis, but most deaths in severely burn-injured patients are still due to burn wound sepsis or ..
  2. pmc Wound microbiology and associated approaches to wound management
    P G Bowler
    ConvaTec Global Development Center, Deeside, Flintshire, United Kingdom
    Clin Microbiol Rev 14:244-69. 2001
    ....
  3. pmc Interactions of methicillin resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in polymicrobial wound infection
    Irena Pastar
    Department of Dermatology and Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e56846. 2013
    ..Polymicrobial wound infection in the presence of P...
  4. ncbi Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing
    Anandev N Gurjala
    Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Wound Repair Regen 19:400-10. 2011
    ....
  5. pmc An in vivo polymicrobial biofilm wound infection model to study interspecies interactions
    Trevor Dalton
    Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
    PLoS ONE 6:e27317. 2011
    ..These data suggest that synergistic interactions between different bacterial species in wounds may contribute to healing delays and/or antibiotic tolerance...
  6. pmc Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds
    Mustafa Fazli
    Department of International Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen N DK 2200, Denmark
    J Clin Microbiol 47:4084-9. 2009
    ..aeruginosa bacteria located in the deeper regions of chronic wounds may play an important role in keeping the wounds arrested in a stage dominated by inflammatory processes...
  7. ncbi Chronic wound infection: facts and controversies
    Abdul R Siddiqui
    Medical Service, Department of Veterans Affairs Medical Center, Dayton, OH 45428, USA
    Clin Dermatol 28:519-26. 2010
    ..b>Wound infection may initially be manifest as bacterial colonization, and it is only when colonization is combined with other ..
  8. ncbi A prospective study of infections in burn patients
    Pia Appelgren
    Department of Infectious Diseases, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    Burns 28:39-46. 2002
    ..The database can be used to evaluate the effects of changes in burn treatment, staffing and design of burn units, and antimicrobial resistance development in relation to antibiotic usage...
  9. pmc Innate defense regulator peptide 1018 in wound healing and wound infection
    Lars Steinstraesser
    Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e39373. 2012
    ....
  10. ncbi Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds
    Mustafa Fazli
    Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Wound Repair Regen 19:387-91. 2011
    ..These results are discussed in relation to the hypothesis that the presence of P. aeruginosa biofilms in chronic wounds may be one of the main factors leading to a persistent inflammatory response and impaired wound healing...
  11. ncbi Predominance of methicillin resistant Staphylococcus aureus -ST88 and new ST1797 causing wound infection and abscesses
    Nyambura Moremi
    Catholic University of Health and Allied Sciences, Mwanza, Tanzania
    J Infect Dev Ctries 6:620-5. 2012
    ..Although there has been a worldwide emergence and spread of methicillin-resistant Staphylococcus aureus (MRSA), little is known about the molecular epidemiology of MRSA in Tanzania...
  12. ncbi Topical silver for preventing wound infection
    Marja N Storm Versloot
    Department of Surgery, Academic Medical Centre at the University of Amsterdam, Meibergdreef 9, Amsterdam, Netherlands, 1105 AZ
    Cochrane Database Syst Rev 3:CD006478. 2010
    ..wound treatments to combat a broad spectrum of pathogens, but evidence of their effectiveness in preventing wound infection or promoting healing is lacking...
  13. pmc Microbiology of animal bite wound infections
    Fredrick M Abrahamian
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Clin Microbiol Rev 24:231-46. 2011
    ....
  14. ncbi Biofilms and bacterial imbalances in chronic wounds: anti-Koch
    Steven L Percival
    Advanced Medical Solutions, Winsford Industrial Estate, Cheshire, UK
    Int Wound J 7:169-75. 2010
    ..We also present two possible hypotheses which could explain the role microorganisms play in non healing chronic wounds and offer possible strategies for combating harmful and detrimental biofilms...
  15. ncbi The effect of time to definitive treatment on the rate of nonunion and infection in open fractures
    Brian J Harley
    Division of Orthopaedic Surgery, Department of Surgery, University of Alberta Hospital, Edmonton, Alberta, Canada
    J Orthop Trauma 16:484-90. 2002
    ..To determine the association of other clinical determinants with these same adverse events...
  16. ncbi Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model
    Clark F Schierle
    Laboratory for Repair and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois, USA
    Wound Repair Regen 17:354-9. 2009
    ..deficient in biofilm formation. This represents the first direct evidence for the effect of bacterial biofilms on cutaneous wound healing...
  17. ncbi Effect of silver on burn wound infection control and healing: review of the literature
    Bishara S Atiyeh
    Division Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
    Burns 33:139-48. 2007
    ..The present review aims at examining all available evidence about effects, often contradictory, of silver on wound infection control and on wound healing trying to determine the practical therapeutic balance between antimicrobial ..
  18. ncbi The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds
    R A Cooper
    Centre for Biomedical Sciences, School of Applied Sciences, University of Wales Institute Cardiff, Llandaff Campus, Cardiff, Wales
    J Appl Microbiol 93:857-63. 2002
    ..To determine the sensitivity to honey of Gram-positive cocci of clinical significance in wounds and demonstrate that inhibition is not exclusively due to osmotic effects...
  19. pmc Use of a bioluminescent Pseudomonas aeruginosa strain within an in vitro microbiological system, as a model of wound infection, to assess the antimicrobial efficacy of wound dressings by monitoring light production
    R M S Thorn
    Faculty of Applied Sciences, Frenchay Campus, University of the West of England, Bristol BS16 1QY, United Kingdom
    Antimicrob Agents Chemother 51:3217-24. 2007
    ....
  20. ncbi Persistent wound infection delays epidermal maturation and increases scarring in thermal burns
    Adam J Singer
    Department of Emergency Medicine and Dermatology, State University of New York at Stony Brook, Stony Brook 11794, USA
    Wound Repair Regen 10:372-7. 2002
    ..001. We conclude that our scale is reliable and that persistence of infection 14 days after thermal injury is associated with delayed epidermal maturation and deep scarring...
  21. ncbi Gr-1(+)CD11b(+) cells as an accelerator of sepsis stemming from Pseudomonas aeruginosa wound infection in thermally injured mice
    Makiko Kobayashi
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555 0435, USA
    J Leukoc Biol 83:1354-62. 2008
    ..tissues and how this defect contributes to the increased susceptibility to Pseudomonas aeruginosa burn-wound infection. Logarithmic growth of P...
  22. ncbi Pivotal advance: glycyrrhizin restores the impaired production of beta-defensins in tissues surrounding the burn area and improves the resistance of burn mice to Pseudomonas aeruginosa wound infection
    Tsuyoshi Yoshida
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, USA
    J Leukoc Biol 87:35-41. 2010
    ..These results suggest that through the improved production of antimicrobial peptides in tissues surrounding the burn area, sepsis stemming from P. aeruginosa wound infection is controllable by glycyrrhizin in severely burned mice.
  23. ncbi Wound infection and septic shock due to Aeromonas trota in a patient with liver cirrhosis
    Chih Cheng Lai
    Clin Infect Dis 44:1523-4. 2007
  24. ncbi Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment
    J B Wright
    Westaim Biomedical Corp, Fort Saskatchewan, Alberta, Canada
    Am J Infect Control 26:572-7. 1998
    ..Silver may be a useful prophylactic or therapeutic agent for the prevention of wound colonization by organisms that impede healing, including antibiotic-resistant bacteria...
  25. pmc Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections
    Shiwani K Arora
    Department of Medicine Infectious Diseases, P O Box 100277, University of Florida, Gainesville, Florida 32610, USA
    Infect Immun 73:4395-8. 2005
    ..This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection...
  26. ncbi Human beta-defensin-3 promotes wound healing in infected diabetic wounds
    Tobias Hirsch
    Division of Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Gene Med 11:220-8. 2009
    ..Human beta-defensin (hBD)-3 is antimicrobial active and appears to play a key role in the immune response. The present study aimed to analyse the effect of hBD-3 expression in a model of infected diabetic wounds...
  27. ncbi Host defense peptides in burns
    L Steinstraesser
    Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Burns 30:619-27. 2004
    ....
  28. ncbi Pseudomonas putida war wound infection in a US Marine: a case report and review of the literature
    Robert J Carpenter
    Department of Internal Medicine, National Naval Medical Center, 8901 Rockville Pike, Bethesda, MD 20889, United States
    J Infect 56:234-40. 2008
    ..The objective of this article is to present a case report of a P. putida war wound infection, review previous P...
  29. pmc Characterization of bacterial communities in venous insufficiency wounds by use of conventional culture and molecular diagnostic methods
    Marie S Tuttle
    Case Western Reserve University, University Hospitals Case Medical Center, Department of Dermatology, Cleveland, OH 44106, USA
    J Clin Microbiol 49:3812-9. 2011
    ..Thus, pyrosequencing identified distinctive baseline characteristics of wounds that did not heal by the 6-month follow-up, furthering our understanding of potentially unique microbiome characteristics of chronic wounds...
  30. ncbi Efficacy of bacteriophage treatment in murine burn wound infection induced by klebsiella pneumoniae
    Seema Kumari
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Microbiol Biotechnol 19:622-8. 2009
    ..pneumoniae induces burn wound infection, especially in situations where multiple antibiotic-resistant organisms are encountered.
  31. ncbi Survey of fungi and yeast in polymicrobial infections in chronic wounds
    S E Dowd
    Research and Testing Laboratory, Lubbock, TX, USA
    J Wound Care 20:40-7. 2011
    ..To assess the incidence, abundance and species diversity of fungi in chronic wounds, as well as to describe the associations of major fungi populations...
  32. ncbi Pattern and multiple drug resistance of bacterial pathogens isolated from wound infection at University of Gondar Teaching Hospital, Northwest Ethiopia
    Andargachew Mulu
    Department of Microbiology, Gondar College of Medicine and Health Sciences, University of Gondar, P O Box 196, Gondar, Ethiopia
    Ethiop Med J 44:125-31. 2006
    ..The aim of this study is to assess the pattern of bacterial pathogens from wound infection and their susceptibility to common antibiotics.
  33. ncbi Bacteriophage versus antimicrobial agents for the treatment of murine burn wound infection caused by Klebsiella pneumoniae B5055
    Seema Kumari
    Basic Medical Sciences Building, Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Med Microbiol 60:205-10. 2011
    This study was planned to evaluate the efficacy of silver nitrate and gentamicin in the treatment of burn wound infection and to compare it with phage therapy using an isolated and well-characterized Klebsiella-specific phage, Kpn5...
  34. ncbi The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns
    R A Cooper
    Centre for Biomedical Sciences, School of Applied Sciences, University of Wales Institute, Cardiff, Wales, United Kingdom
    J Burn Care Rehabil 23:366-70. 2002
    ..Honey with proven antibacterial activity has the potential to be an effective treatment option for burns infected or at risk of infection with P. aeruginosa...
  35. pmc Distribution, organization, and ecology of bacteria in chronic wounds
    Klaus Kirketerp-Møller
    Copenhagen Wound Healing Center, Bispebjerg Hospital, Copenhagen, Denmark
    J Clin Microbiol 46:2717-22. 2008
    ..This strongly supports the development of new diagnostic and treatment strategies for chronic wounds...
  36. ncbi Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics
    R D Wolcott
    Southwest Regional Wound Care Center, Lubbock, Texas, USA
    J Wound Care 19:272-8, 280-1. 2010
    ..To compare healing outcomes at a wound healing centre both before and after the introduction of molecular pathogen diagnostics...
  37. ncbi Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston 02114 2698, USA
    Photochem Photobiol 75:51-7. 2002
    ..Our study points to the possible use of this methodology in the rapid control of wounds and other localized infections...
  38. ncbi Bacteriologic analysis of infected dog and cat bites. Emergency Medicine Animal Bite Infection Study Group
    D A Talan
    Department of Medicine, Olive View UCLA Medical Center and UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 340:85-92. 1999
    ..Wound specimens were cultured for aerobic and anaerobic bacteria at a research microbiology laboratory and, in some cases, at local hospital laboratories...
  39. ncbi Validation of the Infectious Diseases Society of America's diabetic foot infection classification system
    Lawrence A Lavery
    Department of Surgery, Scott and White Hospital, Texas A and M University Health Science Center College of Medicine, Temple, Texas, USA
    Clin Infect Dis 44:562-5. 2007
    ..6; P<.001) with increasing infection severity. The Infectious Diseases Society of America's foot infection classification system may be a useful tool for grading foot infections...
  40. ncbi A wound-isolated Pseudomonas aeruginosa grows a biofilm in vitro within 10 hours and is visualized by light microscopy
    Catherine Harrison-Balestra
    University of Miami School of Medicine, FL, USA
    Dermatol Surg 29:631-5. 2003
    ..A biofilm consists of an exopolysaccharide matrix that is produced and secreted by certain species of bacteria...
  41. ncbi Bacteria and wound healing
    Ruth Edwards
    Wound Healing Research Unit, University of Wales College of Medicine, Cardiff, UK
    Curr Opin Infect Dis 17:91-6. 2004
    ..b>Wound infection is detrimental to wound healing, but the diagnosis and management of wound infection is controversial, and ..
  42. ncbi Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window
    R D Wolcott
    Southwest Regional Wound Care Center, Lubbock, TX, USA
    J Wound Care 19:320-8. 2010
    ..To investigate the hypothesis that newly formed wound biofilms (or bioburdens) are more susceptible to antimicrobial treatment...
  43. ncbi Evidence to support the therapeutic potential of bacteriophage Kpn5 in burn wound infection caused by Klebsiella pneumoniae in BALB/c mice
    Seema Kumari
    Basic Medical Sciences Building, Department of Microbiology, Panjab University, Chandigarh, India
    J Microbiol Biotechnol 20:935-41. 2010
    ..examined the therapeutic potential of phage Kpn5 in the treatment of Klebsiella pneumoniae B5055-induced burn wound infection in a mouse model. An experimental model of contact burn wound infection was established in mice employing K...
  44. ncbi The use of silver coated dressings on donor site wounds: a prospective, controlled matched pair study
    M E Innes
    The Ross Tilley Burn Center, Sunnybrook and Women's College Health Sciences Center, 2075 Bayview Ave, Ont, M4N 3M5, Toronto, Canada
    Burns 27:621-7. 2001
    ..Donor sites dressed with Acticoat had significantly worse scars at 1 and 2 months but this difference resolved by 3 months. Our findings do not support the use of Acticoat as a skin graft donor site dressing...
  45. ncbi Review article: Animal bites: an update for management with a focus on infections
    Claire Dendle
    Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia
    Emerg Med Australas 20:458-67. 2008
    ..All bat bites are of high risk and should receive post-exposure prophylaxis for rabies. Workers handling bats should be offered routine immunization...
  46. pmc Delayed wound healing in diabetic (db/db) mice with Pseudomonas aeruginosa biofilm challenge: a model for the study of chronic wounds
    Ge Zhao
    Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington 98195, USA
    Wound Repair Regen 18:467-77. 2010
    ..This model may provide an approach to study the role of microbial biofilms in chronic wounds as well as the effect of specific biofilm therapy on wound healing...
  47. ncbi Current concepts regarding the effect of wound microbial ecology and biofilms on wound healing
    Carrie E Black
    Department of General Surgery, General Surgery Residency Program, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA
    Surg Clin North Am 90:1147-60. 2010
    ..Topical antimicrobial agents and antibiotics may be effective in the treatment of the wound bed after debridement in the prevention of biofilm reformation...
  48. pmc Influence of deep sternal wound infection on long-term survival after cardiac surgery
    Sebastian Colombier
    Department of Cardiovascular Surgery, University Hospital Lausanne, Switzerland
    Med Sci Monit 19:668-73. 2013
    This study aimed to investigate the influence of deep sternal wound infection on long-term survival following cardiac surgery.
  49. ncbi Incidence and bacteriology of burn infections at a military burn center
    Edward F Keen
    San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:461-8. 2010
    ....
  50. ncbi The truth about silver
    Liza G Ovington
    Ovington and Associates, Inc, Miami, Fla, USA
    Ostomy Wound Manage 50:1S-10S. 2004
    ..a topical antimicrobial: 1) Are there different forms of silver? 2) How does the amount of silver released into the wound environment correlate with clinical benefit? 3) How does the rate of silver release correlate with clinical benefit?..
  51. ncbi Incidence of and preoperative risk factors for Staphylococcus aureus bacteremia and chest wound infection after cardiac surgery
    Zeina A Kanafani
    American University of Beirut Medical Center, Beirut, Lebanon
    Infect Control Hosp Epidemiol 30:242-8. 2009
    ..aureus infections in cardiac surgery patients, to identify preoperative risk factors for these infections, and to establish a patient risk profile by means of data available to clinicians prior to surgery...
  52. ncbi The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis
    S E Blair
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, Australia
    Eur J Clin Microbiol Infect Dis 28:1199-208. 2009
    ..Taken together, these data indicate that honey is an effective topical antimicrobial agent that could help reduce some of the current pressures that are promoting antibiotic resistance...
  53. ncbi Validation of a diabetic wound classification system. The contribution of depth, infection, and ischemia to risk of amputation
    D G Armstrong
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio, Texas 7703, USA
    Diabetes Care 21:855-9. 1998
    ..To validate a wound classification instrument that includes assessment of depth, infection, and ischemia based on the eventual outcome of the wound...
  54. ncbi Skin and soft-tissue infections among tsunami survivors in southern Thailand
    Narin Hiransuthikul
    Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Infect Dis 41:e93-6. 2005
    ..Most isolates were susceptible to aminoglycosides, third- and fourth-generation cephalosporins, quinolones, and imipenem but were resistant to amoxicillin-clavulanate and first-generation cephalosporins...
  55. ncbi A novel titanium wound chamber for the study of wound infections in pigs
    Lars Steinstraesser
    Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Comp Med 56:279-85. 2006
    ..After inoculation of the chambers, wound infection was established and maintained for 14 d. Despite infection, no systemic effects were noted...
  56. pmc Infections
    Brendan Healy
    University Hospital of Wales, Cardiff
    BMJ 332:838-41. 2006
  57. ncbi Diagnostic validity of three swab techniques for identifying chronic wound infection
    Sue E Gardner
    Center for Research in the Implementation of Innovative Strategies in Practice CRIISP, Iowa City VA Medical Center, IA, USA
    Wound Repair Regen 14:548-57. 2006
    This study examined the diagnostic validity of three different swab techniques in identifying chronic wound infection. Concurrent swab specimens of chronic wounds were obtained using wound exudate, the Z-technique, and the Levine ..
  58. pmc Bacterial inactivation of wound infection in a human skin model by liquid-phase discharge plasma
    Paul Y Kim
    Department of Electrical and Computer Engineering, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e24104. 2011
    ..We investigate disinfection of a reconstructed human skin model contaminated with biofilm-formative Staphylococcus aureus employing plasma discharge in liquid...
  59. pmc Pseudomonas syringae pv. syringae uses proteasome inhibitor syringolin A to colonize from wound infection sites
    Johana C Misas-Villamil
    Plant Chemetics Lab, Max Planck Institute for Plant Breeding Research, Cologne, Germany
    PLoS Pathog 9:e1003281. 2013
    ..The molecular mechanisms used by pathogens to suppress containment at wound infection sites are poorly understood...
  60. ncbi Wound infection-associated pain
    R J White
    University of Worcester, UK
    J Wound Care 18:245-9. 2009
    Not only does wound infection and the release of pro-inflammatory modulators result in pain and delayed healing, but pain-related stress reduces the immune response to infection. Treatment of pain and infection should be equal priorites.
  61. ncbi Novel biomarkers for the detection of wound infection by wound fluid RT-PCR in rats
    Mayumi Asada
    Department of Gerontological Nursing Wound Care Management, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Exp Dermatol 21:118-22. 2012
    b>Wound infection is a form of host damage resulting from an imbalance in pathogen virulence and the host immune response...
  62. ncbi Effects of 630-, 660-, 810-, and 905-nm laser irradiation delivering radiant exposure of 1-50 J/cm2 on three species of bacteria in vitro
    Ethne L Nussbaum
    Rehabilitation Services, Mount Sinai Hospital and Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada
    J Clin Laser Med Surg 20:325-33. 2002
    ..To examine the effects of low-intensity laser therapy (LILT) on bacterial growth in vitro...
  63. pmc Phage therapy of Pseudomonas aeruginosa infection in a mouse burn wound model
    Catherine S McVay
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Antimicrob Agents Chemother 51:1934-8. 2007
    ..m. or s.c. route, which may explain the differences in the efficacies of these three different routes of administration...
  64. ncbi Therapeutic efficacy of an antibiotic-loaded nanosheet in a murine burn-wound infection model
    Akihiro Saito
    Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162 8480, Japan
    Acta Biomater 8:2932-40. 2012
    ..The TC-nanosheet significantly improved burn-wound infection by P. aeruginosa in mice...
  65. ncbi Prediction of traumatic wound infection with a neural network-derived decision model
    Richard L Lammers
    Department of Emergency Medicine, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, MI 49008, USA
    Am J Emerg Med 21:1-7. 2003
    ..b>Wound infection was the single output variable...
  66. ncbi Identifying infection in chronic wounds
    Cynthia A Fleck
    Clinical Marketing for Medline Industries, Advanced Wound Care Division, Mundelein, IL, USA
    Adv Skin Wound Care 19:20-1. 2006
  67. ncbi Fighting infection in chronic wounds
    Cynthia A Fleck
    Medline Industries, Advanced Wound Care Division, Mundelein, IL, USA
    Adv Skin Wound Care 19:184, 186, 188. 2006
  68. pmc Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection
    H Calum
    Department of Clinical Microbiology, Rigshospitalet, Denmark
    Clin Exp Immunol 156:102-10. 2009
    ..Using this novel mouse model of thermal injury a decline of peripheral leucocytes was observed, whereas the increased local inflammatory response at the site of infection showed reduced capacity to contain and eliminate the infection...
  69. ncbi Monitoring of bactericidal action of laser by in vivo imaging of bioluminescent E. coli in a cutaneous wound infection
    Samir Jawhara
    UPRES EA 2689 INSERM French National Institute of Health and Medical Research IFR 114, Pavillon Vancostenobel, Lille University Hospital, 59037, Lille, Cedex, France
    Lasers Med Sci 21:153-9. 2006
    ..This study aimed to evaluate the bactericidal action of an 810-nm diode laser in a cutaneous wound infection. An Escherichia coli strain was transformed with a shuttle vector (pRB474) containing firefly luciferase gene ..
  70. ncbi Swab cultures for diagnosing wound infections: a literature review and clinical guideline
    Phyllis A Bonham
    College of Nursing, Medical University of South Carolina, Charleston, SC 29425, USA
    J Wound Ostomy Continence Nurs 36:389-95. 2009
    ..Swab culture is the most frequently employed method of confirming wound infection in the United States, but a standardized procedure is lacking...
  71. ncbi An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities
    Katja E Hill
    Wound Biology Group, Tissue Engineering and Reparative Dentistry, Cardiff University School of Dentistry, Heath Park, Cardiff CF14 4XY, UK
    J Antimicrob Chemother 65:1195-206. 2010
    ..In the present study, an in vitro model of chronic wound biofilms was developed to assess the efficacy of antimicrobial treatments for use in the wound environment...
  72. ncbi Locally delivered antibodies combined with systemic antibiotics confer synergistic protection against antibiotic-resistant burn wound infection
    A G Felts
    Anthony G Gristina Institute for Biomedical Research, Herndon, Virginia, USA
    J Trauma 49:873-8. 2000
    ..Nosocomially derived gram-negative infections, particularly from antibiotic-resistant pathogens, are a cause of morbidity in patients with severe burn wounds...
  73. ncbi Understanding the host inflammatory response to wound infection: an in vivo study of Klebsiella pneumoniae in a rabbit ear wound model
    Akhil K Seth
    Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Wound Repair Regen 20:214-25. 2012
    b>Wound infection development is critically dependent on the complex interactions between bacteria and host...
  74. ncbi Effectiveness of antimicrobial photodynamic therapy with a single treatment of RLP068/Cl in an experimental model of Staphylococcus aureus wound infection
    O Simonetti
    Dermatological Clinic, Department of Clinical Medicine and Applied Biotechnology, Universita Politecnica delle Marche, Ancona, Italy
    Br J Dermatol 164:987-95. 2011
    ..Staphylococcus aureus is the most important representative of the staphylococcal group which causes clinically relevant infections within immunocompetent patients...
  75. ncbi Chronic wound infection and antimicrobial use
    Stephan J Landis
    Department of Hospital Medicine, Guelph General Hospital, Guelph, Ontario, Canada
    Adv Skin Wound Care 21:531-40; quiz 541-2. 2008
    To provide the wound care practitioner with a review of the assessment and management of chronic wound infection.
  76. ncbi Novel peptidoglycan-based diagnostic devices for detection of wound infection
    Andrea Hasmann
    Department of Environmental Biotechnology, Graz University of Technology, 8010 Graz, Austria
    Diagn Microbiol Infect Dis 71:12-23. 2011
    Detection of wound infection is based on evaluation of the well-known signs of inflammation like rubor (redness), calor (heat), tumor (swelling), and dolor (pain) by medical doctors and/or time-consuming procedures requiring special ..
  77. ncbi [Efficacy of bacteriophages in complex treatment of patients with burn wounds]
    E B Lazareva
    N.V. Sclifosowsky Recearch Institute of First Aid, Moscow
    Antibiot Khimioter 46:10-4. 2001
    ..Antibody level enhanced but less extensively than in control group. The results of trial demonstrates positive effect of phagotherapy use at the patients with burns...
  78. ncbi Glucan phosphate treatment attenuates burn-induced inflammation and improves resistance to Pseudomonas aeruginosa burn wound infection
    Olga I Lyuksutova
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, 301 University Boulevard, Galveston, TX 77555, USA
    Shock 23:224-32. 2005
    ..on the inflammatory response induced by burn injury and on resistance to Pseudomonas aeruginosa burn wound infection. Mice were exposed to 35% total body surface area burns and were resuscitated with lactated Ringer's (LR) ..
  79. ncbi Two cases of severe sepsis due to Vibrio vulnificus wound infection acquired in the Baltic Sea
    J Ruppert
    Department of Internal Medicine B, University of Greifswald, Germany
    Eur J Clin Microbiol Infect Dis 23:912-5. 2004
    Two severe cases of Vibrio vulnificus wound infection with secondary septicemia occurred during 1 week in August 2003 on the German island of Usedom in the southwestern Baltic Sea...
  80. ncbi A cross-sectional survey of snake oral bacterial flora from Hong Kong, SAR, China
    Ka Keung Lam
    Department of Accident and Emergency, Pok Oi Hospital, Au Tau, New Territories, Hong Kong SAR, People s Republic of China
    Emerg Med J 28:107-14. 2011
    ..To determine the pattern of oral bacterial flora and their sensitivity to antibiotics in freshly captured native snakes in Hong Kong SAR, People's Republic of China...
  81. ncbi Wound infections in tsunami survivors: a commentary
    P L Lim
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 34:582-5. 2005
    ..Therapy for less frequently encountered clinical entities is also discussed, including tetanus, cutaneous and septicaemic melioidosis, post-traumatic mucormycosis, Vibrio vulnificus and Aeromonas hydrophila...
  82. ncbi Propagation of anaerobic bacteria within an aerobic multi-species chronic wound biofilm model
    Y Sun
    Research and Testing Laboratory, Lubbock, TX, USA
    J Wound Care 18:426-31. 2009
    ..In order to better screen antimicrobial and antibiofilm therapeutics, we evaluated the ability of key anaerobes to incorporate and propagate within our aerobic chronic wound biofilm...
  83. pmc Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 5033, USA
    Surgery 148:499-509. 2010
    ..We hypothesize that topical application of a nanoemulsion compound (NB-201) can attenuate burn wound infection. In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and ..
  84. pmc Therapeutic efficacy of "nubiotics" against burn wound infection by Pseudomonas aeruginosa
    Roderic M K Dale
    Oligos Etc, Inc, Wilsonville, Oregon, USA
    Antimicrob Agents Chemother 48:2918-23. 2004
    ..These nubiotics are evaluated here for their in vivo therapeutic efficacy for the treatment of burn wound infection caused by Pseudomonas aeruginosa...
  85. pmc Necessity breeds invention: a study of outpatient management of low velocity gunshot wounds
    A Byrne
    Accident and Emergency Department, Mater Hospital, Belfast, UK
    Emerg Med J 23:376-8. 2006
    ..Wounds are cleaned and minimally debrided under local anaesthetic in the ED. Patients are given oral antibiotics, and reviewed 48 hours later at the ED review clinic...
  86. ncbi Chronic scalp wound infection due to Rhodococcus equi in an immunocompetent patient
    A A Nasser
    Division of Plastic Surgery, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon
    J Infect 42:67-8. 2001
    A case of chronic scalp wound infection due to Rhodococcus equi in an immunocompetent individual following heavily contaminated traumatic injury was successfully treated by combining antibiotics and surgery...
  87. ncbi [Characteristics of war wound infection]
    Nastja Kucisec-Tepes
    Zavod za klinicku mikrobiologiju i hospitalne infekcije Opća bolnica Sveti Duh Sveti Duh 64 10000 Zagreb, Hrvatska
    Acta Med Croatica 60:353-63. 2006
    ....
  88. ncbi Microbial diversity in chronic open wounds
    Daniel N Frank
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, USA
    Wound Repair Regen 17:163-72. 2009
    ....
  89. ncbi Silver absorption and antibacterial efficacy of silver dressings
    A B G Lansdown
    Division of Investigative Sciences, Imperial College School of Medicine, London, UK
    J Wound Care 14:155-60. 2005
    ..To evaluate the patterns of silver release from selected sustained silver-release dressings and the protective role of proteins in wound exudate and wound scale. The bactericidal action of silver in chronic wound therapy is also examined...
  90. ncbi Allogeneic blood transfusion does not increase the risk of wound infection in total knee arthroplasty
    M Basora
    Department of Anesthesiology, Hospital Clinic of Barcelona, Barcelona, Spain
    Vox Sang 98:124-9. 2010
    ..Data from a previous clinical trial on antibiotic prophylaxis in knee arthroplasty were analysed to gain further insight into the relationship between wound infection and both blood transfusion and the storage time of transfused RBCs.
  91. ncbi Activity of histone H1.2 in infected burn wounds
    F Jacobsen
    Department for Plastic Surgery, BG University Hospital Bergmannsheil, University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    J Antimicrob Chemother 55:735-41. 2005
    ..The aim of this study was to investigate the in vitro and in vivo activity of histone H1.2 in infected burn wounds and its potential toxicity...
  92. ncbi Evaluation of cytotoxicity and antimicrobial activity of Acticoat Burn Dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice
    Andrew P Supp
    Department of Research, Shriners Hospitals for Children, Cincinnati, Ohio 45229 3095, USA
    J Burn Care Rehabil 26:238-46. 2005
    ..These results suggest that Acticoat may be suitable as a protective dressing to reduce environmental contamination of CSS, if used in conjunction with additional antimicrobials to control organisms present in the wound...
  93. ncbi Comparison of wound irrigation and tangential hydrodissection in bacterial clearance of contaminated wounds: results of a randomized, controlled clinical study
    Mark S Granick
    Division of Plastic Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Ostomy Wound Manage 53:64-6, 68-70, 72. 2007
    ..Studies to compare the clinical outcomes of various irrigation techniques and pressure ranges are warranted and the potential benefit of selective debridement using the high-pressure parallel waterjet should be investigated...
  94. ncbi Selective antimicrobial activity of maggots against pathogenic bacteria
    Domen Jaklic
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia
    J Med Microbiol 57:617-25. 2008
    ..and Pseudomonas spp. strains. Bacteria from the genus Vagococcus were resistant to the maggot excreta/secreta...
  95. ncbi Wound irrigation in musculoskeletal injury
    J O Anglen
    Orthopaedic Surgery, University of Missouri-Columbia, Columbia 65212, USA
    J Am Acad Orthop Surg 9:219-26. 2001
    ..High-pressure flow has been shown to remove more bacteria and debris and to lower the rate of wound infection compared with low-pressure irrigation, although recent in vitro and animal studies suggest that it may also ..
  96. ncbi A rapid molecular method for characterising bacterial bioburden in chronic wounds
    R D Wolcott
    Southwest Regional Wound Care Center, Lubbock, TX, USA
    J Wound Care 17:513-6. 2008
    ..This case study describes how, unlike traditional culture reports, a modification of this technique rapidly determined that Pseudomonas spp. was present in a chronic wound...
  97. ncbi Protegrin-1 enhances bacterial killing in thermally injured skin
    L Steinstraesser
    Departments of Surgery, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 29:1431-7. 2001
    ..CONCLUSIONS: This study shows that protegrin-1 potentially may be used as an alternative or adjunct therapy to standard agents used to treat wound infections...
  98. ncbi Prospective analysis of nosocomial infection rates, antibiotic use, and patterns of resistance in a burn population
    Lucy Wibbenmeyer
    Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52246, USA
    J Burn Care Res 27:152-60. 2006
    ....
  99. ncbi Do maggots have an influence on bacterial growth? A study on the susceptibility of strains of six different bacterial species to maggots of Lucilia sericata and their excretions/secretions
    G Cazander
    Department of Trauma Surgery, VU University Medical Center, P O Box 7057, 1007MB Amsterdam, The Netherlands
    J Tissue Viability 18:80-7. 2009
    ..The present study reinvestigates the susceptibility of six bacterial strains to maggots and their ES...
  100. ncbi Clinical, epidemiological, and microbiological features of Vibrio vulnificus biogroup 3 causing outbreaks of wound infection and bacteraemia in Israel. Israel Vibrio Study Group
    N Bisharat
    Infectious Diseases Unit, Ha Emek Medical Center, Afula, Israel
    Lancet 354:1421-4. 1999
    Vibrio vulnificus is a gram-negative bacterium that causes septicaemia and wound infection. Cases occur sporadically, and no previous outbreaks due to a common source or a clonal strain have been reported...
  101. ncbi Increased burn patient survival with once-a-day high dose teicoplanin and netilmicin. An Italian multicenter study
    L Donati
    Div Chirurgia Plastica e Centro Ustioni, Servizio di Microbiologia, , Milano, Italy
    J Chemother 10:47-57. 1998
    ..that when the results are stratified by means of the Roi risk index, 396 of the 530 patients who contracted wound infection (84%) after chemoprophylaxis were in the first three categories and a mean of 95% survived...

Research Grants64

  1. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..bioconjugate vaccine in rodent models of staphylococcal infection, including bacteremia, pneumonia, wound infection, and endocarditis;(4) investigate the immune correlates of protection against S...
  2. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..combine with a PDT regimen mediated by a fullerene and white light to save mice from dying in a Pseudomonas wound infection model...
  3. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..In pregnancy, GBS can cause urinary tract infections, chorioamnionitis, postpartum wound infection, pyelonephritis, sepsis, and rarely meningitis...
  4. Augmentation of Innate Anti-Microbial Immunity by TLR4 Agonists
    Edward R Sherwood; Fiscal Year: 2013
    ..Pre-clinical studies will establish the safety and efficacy of MPLA in large animal models of burn wound infection and post-burn pneumonia...
  5. Preventing Burn Wound Infection Using a Novel Free Radical Sterilization System
    BENJAMIN DAVID SADOWITZ; Fiscal Year: 2011
    ..Current, standard-of-care strategies for the prevention of burn wound infection involve the use of topical antimicrobials, but these topical agents do no kill 100% of microorganisms and ..
  6. Epigenetic misregulation of immune responses after alcohol exposure and injury
    BRENDA JEAN CURTIS; Fiscal Year: 2012
    ..by applicant): Alcohol intoxication prior to traumatic injury delays wound healing and increases the risk for wound infection. Since over half of trauma patients have blood alcohol levels at or above the legal limit, it is imperative ..
  7. Hemostatic-antibiotic Combination for Prevention of MRSA Surgical Site Infections
    Timothy C Fisher; Fiscal Year: 2010
    ..Ostene-V has the potential to significantly reduce the incidence of MRS wound infection, and have a major impact on post-operative infection related deaths, disability, and overall cost of ..
  8. Molecular basis of Pseudomonas aeruginosa persistence in chronic wound infections
    Soyeon Lippman; Fiscal Year: 2013
    ..this important public health issue, comprehensive identification using next-generation sequencing and chronic wound infection model in diabetic mice will be used in these specific aims: (1) Identify P...
  9. A novel Structure Based Vaccine for staphylococcal alpha hemolysin
    Rajan P Adhikari; Fiscal Year: 2013
    ..models of infection: pneumonia, subcutaneous abscess model representing SSTI, bacteremia/sepsis, and surgical wound infection. This proposal is a collaborative effort between IBT and Dr...
  10. A Portable Wound Hemostasis System Using a Hydrogel Polymeric Foam
    Edward Rodriguez; Fiscal Year: 2013
    ..wound contamination can be initially neglected, but it is unclear if doing so facilitates the risk of delayed wound infection. Furthermore, there ae no standards for the application of hemostatic, analgesic or antiseptic agents to an ..
  11. Surgical Treatment Outcomes for Patients with Psychiatric Disorders (STOPP)
    Laurel A Copeland; Fiscal Year: 2013
    ..g., heart attack, venous thromboembolism, ICU admission, pneumonia, respiratory failure, sepsis, wound infection) by SMI status. Methods...
  12. Photoactivated Antimicrobial Collagen
    BARBARA ANN SOLTZ; Fiscal Year: 2013
    ..It has been reported that 1 of every 24 (4.1%) patients who have inpatient surgery in the US develops a wound infection. These infections are substantial in terms of their impact on morbidity, mortality and resource use...
  13. Clinical Trial of Antimicrobial Skin to treat Diabetic Ulcers
    Mary A Lokuta; Fiscal Year: 2013
    ..host defense peptide human cathelicidin (hCAP-18/LL-37) because it exhibits antimicrobial activity against a broad range of microorganisms, fungi, and viruses and is a critical component of innate defenses against wound infection.
  14. Antimicrobial Biodegradable Bone Graft for Craniofacial/Maxillofacial Application
    Arash Aslani; Fiscal Year: 2013
    ..There are reports of local complications and wound infection rates as high as 100% in civilians suffering gunshot wounds to the face...
  15. Development of a Cell-Derived Human Skin Substitute for Acute and Chronic Wounds
    ALLEN R COMER; Fiscal Year: 2012
    ..leading to dehydration, increased metabolic load, entry of toxic substances, immunosuppression, and wound infection. Currently, there are no full-thickness skin substitutes approved for use in treating these debilitating and ..
  16. ANGIOTENSIN ANALOGS TO TREAT WOUND HEALING
    Kathleen E Rodgers; Fiscal Year: 2010
    ..of diabetes include chronic skin ulcers that often lead to amputation and loss of life due to persistent wound infection. US Biotest's lead compound, NorLeu3-A(1-7), has been shown in pre-clinical studies to be significantly ..
  17. New Stereoregular Functionalized Fullerenes as Nanomedicines for PDT
    Long Y Chiang; Fiscal Year: 2012
    ..2) For fullerene-mediated PDT treatment against localized infections we will study a mouse model of wound infection using genetically engineered bioluminescent bacteria combined with optical imaging to follow the progress of ..
  18. Extracellular ATP in biofilm formation and wound infection
    Chuanwu Xi; Fiscal Year: 2013
    ....
  19. Antimicrobial Hydrogels for Prevention of Surgical Site Infections (SSIs)
    Diego Benitez; Fiscal Year: 2012
    ..Selected preparations will be tested in pilot studies of SSI models for prevention of wound infection. A lead compound will be chosen...
  20. Long-Term Broad-Spectrum Prevention of Implant-Related Infections
    Kyumin Whang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Deep wound infection following total joint arthroplasty is a devastating complication for physician and patient, a leading cause of morbidity, and a significant economic burden to the healthcare ..
  21. Moving the Field Forward: Evaluation of Antibiotic Prescribing Practices, the Cli
    TIMOTHY CONRAD JENKINS; Fiscal Year: 2013
    ..endpoint definitions in patients hospitalized with cellulitis/erysipelas, major cutaneous abscess, and wound infection The assessment of clinical response and decision of treatment duration for patients hospitalized with SSTI is ..
  22. Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes
    David J Vachon; Fiscal Year: 2012
    ....
  23. Development of Infection-Resistant Suture Materials
    Matthew Phaneuf; Fiscal Year: 2004
    ..the current infection rates in conjunction with the costs to treat these patients ($2,300/episode), surgical wound infection results in an annual cost to the healthcare system of greater than $750 million...
  24. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..This hypothesis will be tested in staphylococcal animal models of subcutaneous abscess formation and surgical wound infection. These models are clinically relevant, low-inoculum murine models of staphylococcal disease that mimic ..
  25. Development of Infection-Resistant Suture Materials
    Matthew Phaneuf; Fiscal Year: 2007
    ..The goal of this Phase II is to evaluate these novel infection-resistant sutures in vivo using a wound infection model...
  26. Highly Multiplexed LATE-PCR POC Pathogen Detection for Critical Care
    GREG VICTOR WILLIAMS; Fiscal Year: 2010
    ..assay and Clinical Bio-SeeqTM System to test clinical samples from ICU patients suspected of having a wound infection or sepsis and the results will be compared to replicate samples tested with standard laboratory methods used ..
  27. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    ..who undergo cesarean delivery in the setting of chorioamnionitis are at increased risk of serious pelvic and wound infection. The most severe complications of endometritis (including, rarely, death from whelming sepsis) usually occur ..
  28. A novel optical imaging probe system for assessing wound healing and infection
    Wenjing Hu; Fiscal Year: 2013
    ..by the lack of effective methods to monitor the wound healing status and for the early diagnosis of wound infection. Taking advantage of the recent developments in optical imaging technology, the overall goal of this project ..
  29. Molecular Pathogenesis of Vibrio vulnificus
    PAUL GULIG; Fiscal Year: 2007
    ..bacterium that causes fulminating diseases in susceptible humans: septicemia after ingestion of oysters and wound infection from sea water. The major predisposing factor is iron overload...
  30. Targeting chronic Pseudomonas aeruginosa wound infections
    Colin Manoil; Fiscal Year: 2013
    ..infection, 2) a genome-scale genetic approach (Tn- seq) that can identify bacterial functions required for wound infection persistence, and 3) highly sensitive methodology employing mass spectrometry to identify proteins induced in ..
  31. Local Warming: Effects on Wound Infection and Healing
    JoAnne Whitney; Fiscal Year: 2007
    ..2.3. Perfusion (BF) in the surgical incision on postoperative days 3, 5 and 9 using Laser Doppler Flowmetry (LDF). ..
  32. Diagnostic Tool for the Point-of-Care Detection of Infection in Chronic Wounds
    MITCHELL SANDERS; Fiscal Year: 2009
    ..optimize and validate a novel diagnostic test that will better enable physicians or nurses to detect chronic wound infection at the point-of- care...
  33. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2009
    ..scratch model interfaced with bacterial biofilm, a rafted organ culture model and mouse models of chronic wound infection. Success in this project depends on merging expertise from biofilm science and technology with expertise in ..
  34. STAPHYLOCOCCUS AUREUS FIBRONECTIN-BINDING ADHESINS
    Barbara Menzies; Fiscal Year: 2003
    ..In a non-vaccine approach, a fragment of the FnBP of S. aureus has been used to prevent the establishment of wound infection in a guinea pig model...
  35. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
    ..The incidence of wound infection will be evaluated by a blinded observer, the decision to discharge patients from the hospital will be made by ..
  36. INCREASE OF TOXICITY OF TRACE ANESTHETICS BY UV LIGHT
    JOANNES KARIS; Fiscal Year: 1980
    Ultraviolet irradiation is used in some operating rooms to decrease intraoperative wound infection. Halogenated hydrocarbons are commonly used as anesthetic agents and are known to undergo photodecomposition...
  37. Novel Method to Detect Pathogens for the Diagnosis of Chronic Wound Infection
    JAMES COMOLLI; Fiscal Year: 2007
    ..studies is to develop and validate a new assay that will enhance the ability of clinicians to detect chronic wound infection earlier and with more accuracy...
  38. ACHILLES TENDON LENGTHENING ON PATIENTS WITH DIABETES
    Michael Mueller; Fiscal Year: 2002
    ..The results will have important implications for prevention of wound infection and lower extremity amputation; and improvement in impairments, functional limitations, and disability in ..
  39. Photoactivated Antimicrobial Collagen
    Barbara Soltz; Fiscal Year: 2009
    ..It has been reported that 1 of every 24 (4.1%) patients who have inpatient surgery in the US develops a wound infection. These infections are substantial in terms of their impact on morbidity, mortality and resource use...
  40. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006
    ..We will thus test the hypothesis that the incidence of postoperative wound infection will be less in patients given 60% nitrous oxide than in those given 60% nitrogen during elective colon ..
  41. ON DEMAND ANTIMICROBIAL IODINE IN A WOUND CONTACT MATRIX
    Bruce Gibbins; Fiscal Year: 2002
    b>Wound infection is the single-most important complication encountered in the management of chronic non-healing wounds...
  42. Genetic Engineering of Human Skin Substitutes
    Angela Gibson; Fiscal Year: 2006
    Burn wound infection is a major complication leading to patient morbidity and mortality. Topical antimicrobials are cytotoxic to keratinocytes and compromise engraftment of cultured skin substitutes...
  43. Antimicrobial Dressings for Burn Wound Infection Control
    DON ELROD; Fiscal Year: 2003
    ....
  44. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  45. Effects of Insulin on Post-Burn Hypermetabolism
    Steven Wolf; Fiscal Year: 2007
    ..We will also demonstrate mechanisms by which these changes take place, to provide further basis for anabolic agent therapy during catabolism associated with severe injury. ..
  46. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  47. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  48. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  49. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2007
    ....
  50. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  51. Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)
    Christian Schmidt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Enhancement of Dendritic Cells After Burn Injury
    Tracy Toliver Kinsky; Fiscal Year: 2009
    ..will be examined;2) To determine the ability of Flt3L to increase the resistance of mice to a progressive bum wound infection. Bacterial clearance, survival, and cytokine responses after burn wound infection will be examined;3) To ..
  53. Hospital-Acquired Infections in the Elderly
    Keith Kaye; Fiscal Year: 2008
    ..The risk factor identified for SSI and MDRB and the impact of SSI and MDRB on health outcomes will be used to design and implement future preventive interventions. ..
  54. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  55. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  56. Impact of Gender on Infected Hospitalized Patients
    Robert Sawyer; Fiscal Year: 2006
    ..Data obtained from this research will be used to design interventional studies utilizing hormonal manipulation, i. e., replacement or blockade, to improve outcomes from otherwise lethal infectious diseases. ..
  57. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..
  58. THERMAL INJURY INDUCED ALTERATIONS IN IMMUNE FUNCTION
    Martin Schwacha; Fiscal Year: 2006
    ..This award along with the excellent environment in the Center for Surgical Research for conducting these studies will significantly facilitate the applicant's further development as an Independent Investigator. ..
  59. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  60. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..burn trauma, early excision and grafting, and the use of both local and systemic antimicrobials to control wound infection, burn-related loss of the dermis poses a significant risk for infection in the burn patient...
  61. Extremity War Injuries: Current, State of the Art
    Andrew Pollak; Fiscal Year: 2006
    ..The AAOS requested the $15 million to establish the Orthopaedic Trauma Research Program within the U.S. Army Institute of Surgical Research (ISR) at Fort Sam Houston, Texas. [unreadable] [unreadable] [unreadable] [unreadable]..
  62. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..