urinary tract infections

Summary

Summary: Infections affecting those structures of the body which participate in the secretion and elimination of urine, i.e., the kidney, the ureters, the urinary bladder, and the urethra.

Top Publications

  1. ncbi CDC definitions for nosocomial infections, 1988
    J S Garner
    Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
    Am J Infect Control 16:128-40. 1988
  2. ncbi Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America
    Thomas M Hooton
    Department of Medicine, University of Miami, Florida 33136, USA
    Clin Infect Dis 50:625-63. 2010
  3. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
  4. ncbi Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain
    Benjamin A Rogers
    The University of Queensland, UQ Centre for Clinical Research, Herston, 4006, Brisbane, Australia
    J Antimicrob Chemother 66:1-14. 2011
  5. ncbi Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
    Ceire Costelloe
    Academic Unit of Primary Health Care, NIHR National School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA
    BMJ 340:c2096. 2010
  6. ncbi Epidemiology of urinary tract infections: incidence, morbidity, and economic costs
    Betsy Foxman
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109 2029, USA
    Am J Med 113:5S-13S. 2002
  7. pmc Origins and virulence mechanisms of uropathogenic Escherichia coli
    Travis J Wiles
    Division of Cell Biology and Immunology, Pathology Department, University of Utah, Salt Lake City, Utah 84112 0565, USA
    Exp Mol Pathol 85:11-9. 2008
  8. ncbi The epidemiology of urinary tract infection
    Betsy Foxman
    Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA
    Nat Rev Urol 7:653-60. 2010
  9. ncbi Molecular epidemiology of Escherichia coli producing CTX-M beta-lactamases: the worldwide emergence of clone ST131 O25:H4
    Gisele Peirano
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Int J Antimicrob Agents 35:316-21. 2010
  10. ncbi Epidemiology and antimicrobial susceptibility profiles of Gram-negative bacteria causing urinary tract infections in the Asia-Pacific region: 2009-2010 results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)
    Po Liang Lu
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Antimicrob Agents 40:S37-43. 2012

Detail Information

Publications338 found, 100 shown here

  1. ncbi CDC definitions for nosocomial infections, 1988
    J S Garner
    Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
    Am J Infect Control 16:128-40. 1988
    ..Other hospitals may wish to adopt or modify them for use in their nosocomial infections surveillance programs...
  2. ncbi Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America
    Thomas M Hooton
    Department of Medicine, University of Miami, Florida 33136, USA
    Clin Infect Dis 50:625-63. 2010
    ..These guidelines are intended for use by physicians in all medical specialties who perform direct patient care, with an emphasis on the care of patients in hospitals and long-term care facilities...
  3. ncbi Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Lancet Infect Dis 8:159-66. 2008
    ..Thus, more rapid diagnostic testing of ESBL-producing bacteria and the possible modification of guidelines for community-onset bacteraemia associated with UTIs are required...
  4. ncbi Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain
    Benjamin A Rogers
    The University of Queensland, UQ Centre for Clinical Research, Herston, 4006, Brisbane, Australia
    J Antimicrob Chemother 66:1-14. 2011
    ..Phenotypic detection of the ST131 clone is not possible and DNA-based techniques, including MLST and PCR, are described...
  5. ncbi Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
    Ceire Costelloe
    Academic Unit of Primary Health Care, NIHR National School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA
    BMJ 340:c2096. 2010
    ..To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care...
  6. ncbi Epidemiology of urinary tract infections: incidence, morbidity, and economic costs
    Betsy Foxman
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109 2029, USA
    Am J Med 113:5S-13S. 2002
    b>Urinary tract infections (UTIs) are considered to be the most common bacterial infection...
  7. pmc Origins and virulence mechanisms of uropathogenic Escherichia coli
    Travis J Wiles
    Division of Cell Biology and Immunology, Pathology Department, University of Utah, Salt Lake City, Utah 84112 0565, USA
    Exp Mol Pathol 85:11-9. 2008
    Strains of uropathogenic E. coli (UPEC) are the primary cause of urinary tract infections, including both cystitis and pyelonephritis...
  8. ncbi The epidemiology of urinary tract infection
    Betsy Foxman
    Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA
    Nat Rev Urol 7:653-60. 2010
    b>Urinary tract infections (UTIs) are among the most common bacterial infections acquired in the community and in hospitals...
  9. ncbi Molecular epidemiology of Escherichia coli producing CTX-M beta-lactamases: the worldwide emergence of clone ST131 O25:H4
    Gisele Peirano
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Int J Antimicrob Agents 35:316-21. 2010
    ..it is possible that the medical community may be forced, in the near future, to use carbapenems as the first choice for the empirical treatment of serious infections associated with urinary tract infections originating from the community.
  10. ncbi Epidemiology and antimicrobial susceptibility profiles of Gram-negative bacteria causing urinary tract infections in the Asia-Pacific region: 2009-2010 results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)
    Po Liang Lu
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Antimicrob Agents 40:S37-43. 2012
    ..Resistance Trends (SMART) was expanded to include surveillance of Gram-negative pathogens causing urinary tract infections (UTIs) in the Asia-Pacific region...
  11. ncbi Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem
    Thomas A Russo
    Division of Infectious Diseases, Department of Medicine and Microbiology, The Center for Microbial Pathogenesis, VA Medical Center, University at Buffalo, Buffalo, NY 14214 3001, USA
    Microbes Infect 5:449-56. 2003
    ..coli. New treatments and prevention measures will be needed for improved outcomes and a diminished disease burden...
  12. pmc Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis
    Sheryl S Justice
    Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:1333-8. 2004
    ..This work has developed a technique to observe live infected organs and revealed a complex differentiation pathway that facilitates bacterial persistence in the urinary tract...
  13. pmc Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States
    James A Karlowsky
    Focus Technologies, Inc, 13665 Dulles Technology Drive, Suite 200, Herndon, VA 20171 4603, USA
    Antimicrob Agents Chemother 46:2540-5. 2002
    ..8 to 17.0%) from 1995 to 2001 but demonstrated considerable regional and institutional variation in 2001. Therapies other than SXT may need to be considered in some locations...
  14. ncbi Summary of the AUA Guideline on Management of Primary Vesicoureteral Reflux in Children
    Craig A Peters
    Guidelines Department, American Urological Association, 1000 Corporate Blvd, Linthicum, Maryland 21090, USA
    J Urol 184:1134-44. 2010
    ..From this evidence clinical practice guidelines were developed to manage the clinical scenarios insofar as the data permit...
  15. pmc Molecular characterization and antimicrobial susceptibility testing of Escherichia coli isolates from patients with urinary tract infections in 20 Chinese hospitals
    Xiaoli Cao
    Department of General Surgery, Peking University First Hospital, Beijing 100034, China
    J Clin Microbiol 49:2496-501. 2011
    ..coli isolates, indicating the presence of a large reservoir in the community and a long-term spread of cephalosporin resistance in China...
  16. pmc Food reservoir for Escherichia coli causing urinary tract infections
    Caroline Vincent
    McGill University, Montreal, Quebec H3A 1A2, Canada
    Emerg Infect Dis 16:88-95. 2010
    ..coli from human UTIs. This study provides strong support for the role of food reservoirs or foodborne transmission in the dissemination of E. coli causing common community-acquired UTIs...
  17. pmc Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract
    M Chelsea Lane
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 104:16669-74. 2007
    Uropathogenic Escherichia coli (UPEC) cause most uncomplicated urinary tract infections (UTIs) in humans...
  18. ncbi Antiadhesion therapy for urinary tract infections--a balanced PK/PD profile proved to be key for success
    Xiaohua Jiang
    Institute of Molecular Pharmacy, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Med Chem 55:4700-13. 2012
    The initial step for the successful establishment of urinary tract infections (UTIs), predominantly caused by uropathogenic Escherichia coli, is the adhesion of bacteria to urothelial cells...
  19. pmc Urinary tract infections: new insights into a common problem
    R Kucheria
    Department of Urology, Guy s and St Thomas Hospital NHS Trust, London, UK
    Postgrad Med J 81:83-6. 2005
    ..This review discusses recent advances in the understanding of how the common pathogen, uropathogenic Escherichia coli, interacts with the host to lead to infection...
  20. ncbi Dissemination of ST131 and ST393 community-onset, ciprofloxacin-resistant Escherichia coli clones causing urinary tract infections in Korea
    Mi Young Lee
    Asian Pacific Research Foundation for Infectious Diseases ARFID, Seoul, South Korea
    J Infect 60:146-53. 2010
    ..coli isolates causing urinary tract infections (UTIs) in Korea. In addition, the evidence of clonal spread in the community was also examined.
  21. pmc Bacteria-induced uroplakin signaling mediates bladder response to infection
    Praveen Thumbikat
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    PLoS Pathog 5:e1000415. 2009
    b>Urinary tract infections are the second most common infectious disease in humans and are predominantly caused by uropathogenic E. coli (UPEC)...
  22. ncbi Intracellular bacterial biofilm-like pods in urinary tract infections
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 301:105-7. 2003
    ..The discovery of intracellular biofilm-like pods explains how bladder infections can persist in the face of robust host defenses...
  23. pmc Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis
    S M Jacobsen
    Department of Biomedical Sciences, Dental School, University of Maryland Baltimore, Room 9209, 650 W Baltimore Street, Baltimore, MD 21201, USA
    Clin Microbiol Rev 21:26-59. 2008
    Catheter-associated urinary tract infections (CAUTIs) represent the most common type of nosocomial infection and are a major health concern due to the complications and frequent recurrence...
  24. ncbi An international survey of the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections: the ECO.SENS Project
    G Kahlmeter
    Department of Clinical Microbiology, Central Hospital, SE 351 85 Växjö, Sweden
    J Antimicrob Chemother 51:69-76. 2003
    ..investigate the prevalence and susceptibility of pathogens causing community-acquired acute uncomplicated urinary tract infections (UTIs)...
  25. pmc A murine model of urinary tract infection
    Chia Suei Hung
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Protoc 4:1230-43. 2009
    b>Urinary tract infections (UTIs) inflict extreme pain and discomfort to those affected and have profound medical and socioeconomic impact...
  26. pmc TonB-dependent systems of uropathogenic Escherichia coli: aerobactin and heme transport and TonB are required for virulence in the mouse
    A G Torres
    Department of Microbiology and the Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Infect Immun 69:6179-85. 2001
    ..To determine the importance of the individual TonB-dependent iron transport systems during urinary tract infections, mutants defective in each of the CFT073 high-affinity iron transport systems were constructed and tested ..
  27. ncbi Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili
    Kelly J Wright
    Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell Microbiol 9:2230-41. 2007
    Uropathogenic Escherichia coli, the predominant causative agent of urinary tract infections, use type 1 pili to bind and invade bladder epithelial cells...
  28. pmc Epidemic clonal groups of Escherichia coli as a cause of antimicrobial-resistant urinary tract infections in Canada, 2002 to 2004
    James R Johnson
    Infectious Diseases 111F, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Antimicrob Agents Chemother 53:2733-9. 2009
    ..coli ST131 being the major contributors. These clonal groups appear to be more virulent than comparably resistant isolates, possibly contributing to their success as emerging multi-drug-resistant pathogens...
  29. ncbi FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation
    Tobias Klein
    Institute of Molecular Pharmacy, Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Med Chem 53:8627-41. 2010
    ..With FimH antagonist, the great potential for the effective treatment of urinary tract infections with a new class of orally available antiinfectives could be demonstrated.
  30. ncbi Increased resistance to first-line agents among bacterial pathogens isolated from urinary tract infections in Latin America: time for local guidelines?
    Soraya S Andrade
    Laboratório Especial de Microbiologia Clínica, Universidade Federal de Sao Paulo, 04025 010 São Paulo, SP, Brazil
    Mem Inst Oswaldo Cruz 101:741-8. 2006
    ..phenotypes and antimicrobial resistance rates among pathogens recovered from community-acquired urinary tract infections (CA-UTI) is an increasing problem in specific regions, limiting therapeutic options...
  31. ncbi Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections
    K Gupta
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Infect Dis 178:446-50. 1998
    ..5; P = .02). Thus, absence of H2O2-positive lactobacilli may be important in the pathogenesis of recurrent UTI by facilitating E. coli introital colonization...
  32. ncbi Cranberries for preventing urinary tract infections
    Ruth G Jepson
    Department of Nursing and Midwifery, University of Stirling, Stirling, UK
    Cochrane Database Syst Rev 10:CD001321. 2012
    Cranberries have been used widely for several decades for the prevention and treatment of urinary tract infections (UTIs). This is the third update of our review first published in 1998 and updated in 2004 and 2008.
  33. pmc Clonal composition of Escherichia coli causing community-acquired urinary tract infections in the State of Rio de Janeiro, Brazil
    Rubens C S Dias
    Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Microb Drug Resist 15:303-8. 2009
    ..coli UTIs. Thus, as in North America and Europe, UPECs that cause UTI in Rio de Janeiro also show clonal distribution, and a substantial proportion of drug-resistant UTI is caused by a small set of genetically related E. coli strains...
  34. ncbi Genomic analysis uncovers a phenotypically diverse but genetically homogeneous Escherichia coli ST131 clone circulating in unrelated urinary tract infections
    Gemma Clark
    Pathogen Research Group, Nottingham Trent University, Nottingham, UK
    J Antimicrob Chemother 67:868-77. 2012
    ..To determine variation at the genome level in Escherichia coli ST131 clinical isolates previously shown to be phenotypically diverse...
  35. ncbi Role of bacterial biofilms in urinary tract infections
    J K Hatt
    Research Service, Veterans Affairs Medical Center, Emory University School of Medicine, Atlanta, GA, USA
    Curr Top Microbiol Immunol 322:163-92. 2008
    Bacterial urinary tract infections represent the most common type of nosocomial infection...
  36. ncbi Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy
    J Schnarr
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Hamilton, Canada
    Eur J Clin Invest 38:50-7. 2008
    Symptomatic and asymptomatic bacteriuria is common in pregnant women. A history of previous urinary tract infections and low socioeconomic status are risk factors for bacteriuria in pregnancy...
  37. pmc Conditioning of uropathogenic Escherichia coli for enhanced colonization of host
    Jean M Bower
    Pathology Department, Division of Cell Biology and Immunology, University of Utah, 15 North Medical Drive East, Salt Lake City, UT 84112 0565, USA
    Infect Immun 77:2104-12. 2009
    ..Here we show that UPEC, the primary cause of urinary tract infections, can be conditioned to grow at higher rates in the presence of acidified sodium nitrite (ASN), a model ..
  38. ncbi Antimicrobial resistance in community-acquired urinary tract infections: results from the Korean Antimicrobial Resistance Monitoring System
    Seung Ju Lee
    Department of Urology, St Vincent s Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea
    J Infect Chemother 17:440-6. 2011
    ..to clinically relevant bacterial uropathogens were collected from patients with community-acquired urinary tract infections (UTIs)...
  39. ncbi Antibiotic prophylaxis and recurrent urinary tract infection in children
    Jonathan C Craig
    Screening and Test Evaluation Program and the School of Public Health, University of Sydney, Sydney, NSW, Australia
    N Engl J Med 361:1748-59. 2009
    ..This study from four Australian centers examined whether low-dose, continuous oral antibiotic therapy prevents urinary tract infection in predisposed children...
  40. ncbi The ARESC study: an international survey on the antimicrobial resistance of pathogens involved in uncomplicated urinary tract infections
    Gian Carlo Schito
    Sezione di Microbiologia del DISCMIT, University of Genoa, Genoa, Italy
    Int J Antimicrob Agents 34:407-13. 2009
    ....
  41. ncbi Antibiotic resistance in pathogens causing community-acquired urinary tract infections in India: a multicenter study
    Atul Kothari
    Department of Microbiology, Max Heart and Vascular Institute, Saket, India
    J Infect Dev Ctries 2:354-8. 2008
    Empiric treatment of community-acquired urinary tract infections (CA-UTI) is determined by the antibiotic sensitivity patterns of uropathogens in a population...
  42. pmc Effect of inactivation of the global oxidative stress regulator oxyR on the colonization ability of Escherichia coli O1:K1:H7 in a mouse model of ascending urinary tract infection
    James R Johnson
    University of Minnesota Department of Medicine, Infectious Diseases 111F, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Infect Immun 74:461-8. 2006
    ..coli. They also suggest that neutrophil phagocyte oxidase is not critical for defense against E. coli UTI and that the major oxidative stresses against which OxyR protects E. coli within the host milieu are not phagocyte derived...
  43. ncbi Development of quality indicators for the antibiotic treatment of complicated urinary tract infections: a first step to measure and improve care
    H S Hermanides
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Clin Infect Dis 46:703-11. 2008
    ..The aim of this study was to develop a set of valid, reliable, and applicable indicators to assess the quality of antibiotic use in the treatment of hospitalized patients with complicated UTI...
  44. pmc Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics
    Matthew G Blango
    Pathology Department, Division of Cell Biology and Immunology, University of Utah, Salt Lake City, UT 84112 0565, USA
    Antimicrob Agents Chemother 54:1855-63. 2010
    Numerous antibiotics have proven to be effective at ameliorating the clinical symptoms of urinary tract infections (UTIs), but recurrent and chronic infections continue to plague many individuals...
  45. pmc Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract
    Indira U Mysorekar
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:14170-5. 2006
    Recurrent urinary tract infections (rUTIs) are a source of considerable morbidity in women. The infecting bacteria in both rUTIs and a de novo acute infection have been thought to originate from an extraurinary location...
  46. ncbi Risk factors for antibiotic-resistant Escherichia coli isolated from community-acquired urinary tract infections in Dakar, Senegal
    Jacques Albert Dromigny
    Laboratoire de Microbiologie, Institut Pasteur de Dakar, Senegal
    J Antimicrob Chemother 56:236-9. 2005
    ....
  47. ncbi Biofilms and catheter-associated urinary tract infections
    Sanjay Saint
    Ann Arbor VA Medical Center, Ann Arbor, MI, USA
    Infect Dis Clin North Am 17:411-32. 2003
    ..Future research should focus on additional methods for preventing this common infection...
  48. pmc Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization
    Kelly J Wright
    Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Infect Immun 73:7657-68. 2005
    In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, ..
  49. ncbi Epidemiology of urinary tract infections: incidence, morbidity, and economic costs
    Betsy Foxman
    Dis Mon 49:53-70. 2003
    b>Urinary tract infections (UTIs) are considered to be the most common bacterial infection...
  50. ncbi Intracellular lifestyles and immune evasion strategies of uropathogenic Escherichia coli
    David A Hunstad
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Microbiol 64:203-21. 2010
    Paradigms in the pathogenesis of urinary tract infections have shifted dramatically as a result of recent scientific revelations...
  51. ncbi Bacterial profile and drug susceptibility pattern of urinary tract infection in pregnant women at Tikur Anbessa Specialized Hospital Addis Ababa, Ethiopia
    Addisu Assefa
    Department of Biology, Science Faculty, Addis Ababa University, P O Box 1176, Addis Ababa
    Ethiop Med J 46:227-35. 2008
    ..Urinary tract infection (UTI) is a common complication of pregnancy. It may be symptomatic or asymptomatic...
  52. pmc Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial
    Jutta Bleidorn
    Institute of General Practice Family Medicine, Hanover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    BMC Med 8:30. 2010
    Uncomplicated lower urinary tract infections (UTI) are usually treated with antibiotics. However, there is little evidence for alternative therapeutic options...
  53. ncbi Absolute and relative accuracy of rapid urine tests for urinary tract infection in children: a meta-analysis
    Gabrielle J Williams
    Centre for Kidney Research, The Children s Hospital at Westmead, Sydney, Australia
    Lancet Infect Dis 10:240-50. 2010
    ..Rapid tests are negative in around 10% of children with a urinary tract infection and cannot replace urine culture. If resources allow, microscopy with Gram stain should be the single rapid test used...
  54. pmc Engineering out the risk for infection with urinary catheters
    D G Maki
    University of Wisconsin Medical School, Madison, Wisconsin, USA
    Emerg Infect Dis 7:342-7. 2001
    ....
  55. ncbi Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval
    C D J den Heijer
    Department of Medical Microbiology, Maastricht University Medical Centre CAPHRI, Maastricht, The Netherlands
    J Antimicrob Chemother 65:2128-33. 2010
    To optimize empirical treatment of urinary tract infections (UTIs), regular evaluation of the antibiotic susceptibility of the most common uropathogen, Escherichia coli, is necessary...
  56. ncbi Ten-year results of randomized treatment of children with severe vesicoureteral reflux. Final report of the International Reflux Study in Children
    Ulf Jodal
    The Pediatric Uro Nephrologic Centre, The Queen Silvia Children s Hospital, Goteborg University, 416 85 Gothenburg, Sweden
    Pediatr Nephrol 21:785-92. 2006
    ..73 m2 progressed remarkably well under either medical or surgical management, emphasizing the importance of continued supervision and the entry level of renal function...
  57. ncbi Molecular epidemiology of uropathogenic Escherichia coli
    Shingo Yamamoto
    The Department of Urology, Hyogo College of Medicine, 1 1 Mukogawacho, Nishinomiya, Hyogo 663 8501, Japan
    J Infect Chemother 13:68-73. 2007
    Escherichia coli is the most common cause of complicated as well as uncomplicated urinary tract infections (UTIs). Most of these uropathogenic E...
  58. pmc Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection
    Thomas J Hannan
    Department of Molecular Microbiology and Center for Women s Infectious Disease Research, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Pathog 6:e1001042. 2010
    ..Overall, these results have significant implications for our understanding of how early host-pathogen interactions at the mucosal surface determines the fate of disease...
  59. ncbi The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
    Milan Chromek
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nat Med 12:636-41. 2006
    ..In addition, clinical E. coli strains that were more resistant to LL-37 caused more severe urinary tract infections than did susceptible strains...
  60. pmc High metabolic potential may contribute to the success of ST131 uropathogenic Escherichia coli
    Tarek M Gibreel
    School of Medicine, University of Manchester, Manchester, UK
    J Clin Microbiol 50:3202-7. 2012
    ....
  61. ncbi Laboratory diagnosis of urinary tract infections in adult patients
    Michael L Wilson
    Department of Pathology and Laboratory Services, Denver Health Medical Center, University of Colorado School of Medicine, Denver, Colorado 80204 4507, USA
    Clin Infect Dis 38:1150-8. 2004
    b>Urinary tract infections (UTIs) are among the most common bacterial infections and account for a significant part of the workload in clinical microbiology laboratories...
  62. pmc (CGG)4-based PCR as a novel tool for discrimination of uropathogenic Escherichia coli strains: comparison with enterobacterial repetitive intergenic consensus-PCR
    Wioletta Adamus-Bialek
    Institute of Medical Biology PAS, 106 Lodowa Str, 93 232 Lodz, Poland
    J Clin Microbiol 47:3937-44. 2009
    b>Urinary tract infections are one of the most frequent bacterial diseases in humans, and Escherichia coli is most often the relevant pathogen. A specific pathotype of E. coli, known as uropathogenic E...
  63. pmc Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach
    Swaine L Chen
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:5977-82. 2006
    ..coli isolates from patients with UTI. These studies outline a computational approach that may be broadly applicable for studying strain-specific adaptation and pathogenesis in other bacteria...
  64. ncbi Proteus mirabilis biofilms and catheter-associated urinary tract infections
    Sandra M Jacobsen
    Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD, USA
    Virulence 2:460-5. 2011
    ..P. mirabilis biofilm research will lead to a better understanding of the disease process and will subsequently lead to the development of new prevention, and treatment options...
  65. ncbi The changing pattern of antimicrobial resistance within 42,033 Escherichia coli isolates from nosocomial, community and urology patient-specific urinary tract infections, Dublin, 1999-2009
    Ivor M Cullen
    Departments of Urology, AMNCH, Dublin, Ireland
    BJU Int 109:1198-206. 2012
    ..coli antibiotic resistance rates vary depending on whether the UTI represents a nosocomial, community acquired or urology patient specific infection...
  66. pmc Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection
    Maria Kostakioti
    Department of Molecular Microbiology and Microbial Pathogenesis, Washington University in Saint Louis School of Medicine, St Louis, Missouri, USA
    Infect Immun 80:2826-34. 2012
    b>Urinary tract infections (UTI), primarily caused by uropathogenic Escherichia coli (UPEC), are one of the leading bacterial infections due to their high frequency and rate of recurrence...
  67. pmc Roles of putative type II secretion and type IV pilus systems in the virulence of uropathogenic Escherichia coli
    Ritwij Kulkarni
    Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 4:e4752. 2009
    ..However, the roles of T2SS and T4P in the virulence of extraintestinal pathogenic Escherichia coli have not been determined...
  68. ncbi Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial
    Jarmo Salo
    Department of Paediatrics, Oulu University Hospital, University of Oulu, Finland
    Clin Infect Dis 54:340-6. 2012
    Cranberry juice prevents recurrences of urinary tract infections (UTIs) in adult women. The objective of this study was to evaluate whether cranberry juice is effective in preventing UTI recurrences in children.
  69. pmc Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of uncomplicated lower urinary tract infection in women: the LUTIW project
    Sven A Ferry
    Vännäs Primary Health Care Centre, Vännäs, Sweden
    Scand J Prim Health Care 25:49-57. 2007
    ..To analyse associations between symptoms and bacteriuria in uncomplicated lower urinary tract infection in women (LUTIW) and to evaluate outcome of therapy with three different regimens of pivmecillinam or placebo...
  70. pmc The CTX-M-15-producing Escherichia coli clone O25b: H4-ST131 has high intestine colonization and urinary tract infection abilities
    Sophie Vimont
    AP HP, Hôpitaux Universitaires Est Parisien site Tenon, Service de Bacteriologie, Paris, France
    PLoS ONE 7:e46547. 2012
    ..In conclusion, our findings indicate that TN03 is a potent UPEC strain that colonizes the intestinal tract and may persist in the kidneys of infected hosts...
  71. ncbi Sex, drugs, bugs, and age: rational selection of empirical therapy for outpatient urinary tract infection in an era of extensive antimicrobial resistance
    Jaime L Rocha
    Division of Microbiology, Frischmann Aisengart DASA Medicina Diagnóstica and VITA Curitiba Hospital, Curitiba, PR, Brazil
    Braz J Infect Dis 16:115-21. 2012
    ..Optimal empirical therapy of urinary tract infection requires accurate knowledge of local susceptibility patterns, which may vary with organism and patient characteristics...
  72. ncbi Urologic diseases in America project: trends in resource use for urinary tract infections in women
    Tomas L Griebling
    Department of Urology and the Center on Aging, University of Kansas, Kansas City 66160, USA
    J Urol 173:1281-7. 2005
    ..Urinary tract infection (UTI) is one of the most common clinical diagnoses in women. In this study we examined epidemiological, economic and health care use trends for UTI in women in the United States...
  73. ncbi Urinary tract infections in children: a review
    D Buonsenso
    Sacro Cuore Catholic University, Rome, Italy
    Minerva Pediatr 64:145-57. 2012
    ..Nevertheless, the development of a universally accepted diagnostic protocol remains elusive...
  74. ncbi Complications of Foley catheters--is infection the greatest risk?
    Anne Marie Leuck
    VA Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    J Urol 187:1662-6. 2012
    ..Although symptomatic urinary tract infection and asymptomatic bacteriuria are frequently discussed, genitourinary trauma receives comparatively little attention...
  75. pmc Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial
    Ann E Stapleton
    Department of Medicine, University of Washington, Seattle, USA
    Mayo Clin Proc 87:143-50. 2012
    ..To compare the time to urinary tract infection (UTI) and the rates of asymptomatic bacteriuria and urinary P-fimbriated Escherichia coli during a 6-month period in women ingesting cranberry vs placebo juice daily...
  76. ncbi Community-onset genitourinary tract infection due to CTX-M-15-Producing Escherichia coli among travelers to the Indian subcontinent in New Zealand
    Joshua T Freeman
    Department of Clinical Microbiology, Auckland City Hospital, Grafton, Auckland, New Zealand
    Clin Infect Dis 47:689-92. 2008
    ..All had a history of travel to the Indian subcontinent and lacked traditional risk factors for urinary tract infection due to a multidrug-resistant organism...
  77. ncbi Urinary tract infections in the elderly population
    S James Matthews
    Department of Pharmacy Practice, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    Am J Geriatr Pharmacother 9:286-309. 2011
    b>Urinary tract infections (UTIs) are a common problem in the elderly population. The spectrum of disease varies from a relatively benign cystitis to potentially life-threatening pyelonephritis.
  78. ncbi A multiplex PCR method to detect 14 Escherichia coli serogroups associated with urinary tract infections
    Dan Li
    TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 HongDa Street, TEDA, Tianjin 300457, PR China
    J Microbiol Methods 82:71-7. 2010
    b>Urinary tract infections (UTIs) are one of the most common bacterial infections and are predominantly caused by uropathogenic Escherichia coli (UPEC). E...
  79. ncbi Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria
    Ann Pallett
    Department of Microbiology, Southampton University Hospitals NHS Trust, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Antimicrob Chemother 65:iii25-33. 2010
    ..coli is one of the commonest organisms causing urinary tract infections (UTIs) the choice of agents to treat these infections is diminishing...
  80. ncbi Host-pathogen interactions in urinary tract infection
    Greta R Nielubowicz
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0620, USA
    Nat Rev Urol 7:430-41. 2010
    ..Current research is focused on the identification of additional virulence factors and therapeutic or prophylactic targets that might be used in the generation of vaccines against both uropathogens...
  81. pmc Decreased susceptibility to commonly used antimicrobial agents in bacterial pathogens isolated from urinary tract infections in Rwanda: need for new antimicrobial guidelines
    Claude Mambo Muvunyi
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Am J Trop Med Hyg 84:923-8. 2011
    ..was to obtain data on susceptibility patterns of pathogens responsible for both community and hospital urinary tract infections (UTIs); and analyzed risk factors for infection caused by ciprofloxacin-resistant Escherichia coli and ..
  82. ncbi Systematic review and meta-analysis: reminder systems to reduce catheter-associated urinary tract infections and urinary catheter use in hospitalized patients
    Jennifer Meddings
    Department of Internal Medicine, University of Michigan, and 3Ann Arbor VA Medical Center, Ann Arbor, Michigan 48109 0429, USA
    Clin Infect Dis 51:550-60. 2010
    ..To summarize the effect of urinary catheter reminder systems on the rate of CAUTI, urinary catheter use, and the need for recatheterization, we performed a systematic review and meta-analysis...
  83. ncbi Urinary tract infections caused by Pseudomonas aeruginosa: a minireview
    Rahul Mittal
    Division of Infectious Diseases, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Infect Public Health 2:101-11. 2009
    b>Urinary tract infections (UTIs) are a serious health problem affecting millions of people each year. Infections of the urinary tract are the second most common type of infection in the body...
  84. ncbi Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia-Pacific region
    Po Ren Hsueh
    Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Infect 63:114-23. 2011
    b>Urinary tract infections (UTIs) are among the most prevalent infectious diseases in the general population...
  85. pmc Women's views about management and cause of urinary tract infection: qualitative interview study
    G M Leydon
    Primary Medical Care, Community Clinical Sciences Division, University of Southampton School of Medicine, Aldermoor Health Centre, Southampton SO16 5ST
    BMJ 340:c279. 2010
    ..To explore the views of women with urinary tract infection on the acceptability of different strategies for managing the infection, including delayed use of antibiotics, and the cause of infection...
  86. ncbi Urinary tract infection in male veterans: treatment patterns and outcomes
    Dimitri M Drekonja
    Minneapolis Veterans Affairs Health Care System, Minneapolis, MN 55417, USA
    JAMA Intern Med 173:62-8. 2013
    ..The optimal treatment duration and current treatment patterns for urinary tract infection (UTI) in men are unknown. We used Veterans Affairs administrative data to study male UTI treatment and outcomes...
  87. ncbi Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin
    Alev Yilmaz
    Pediatric Nephrology, Bakirkoy Maternity and Childrens Hospital, Bogazkoy Kardelen Villalari No 26 Bahcesehir, Istanbul, Turkey
    Pediatr Nephrol 24:2387-92. 2009
    ..Further investigations with larger patient groups are required to confirm our results...
  88. pmc Adenylate cyclase and the cyclic AMP receptor protein modulate stress resistance and virulence capacity of uropathogenic Escherichia coli
    Grant T Donovan
    Division of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Infect Immun 81:249-58. 2013
    ..of stress resistance and virulence in uropathogenic Escherichia coli (UPEC), the principal cause of urinary tract infections worldwide...
  89. pmc Predictive factors of urinary tract infections among the oldest old in the general population. A population-based prospective follow-up study
    Monique A A Caljouw
    Department of Public Health and Primary Care, Leiden University Medical Center, Netherlands
    BMC Med 9:57. 2011
    b>Urinary tract infections (UTI) are common among the oldest old and may lead to a few days of illness, delirium or even to death. We studied the incidence and predictive factors of UTI among the oldest old in the general population.
  90. ncbi Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospective, double-blinded, placebo-controlled, crossover study
    Todd A Linsenmeyer
    Department of Urology, Kessler Institute for Rehabilitation, West Orange, New Jersey 07052, USA
    J Spinal Cord Med 27:29-34. 2004
    To determine the effectiveness of cranberry supplement at preventing urinary tract infections (UTIs) in persons with spinal cord injury (SCI).
  91. ncbi Uropathogenic Escherichia coli (UPEC) strains may carry virulence properties of diarrhoeagenic E. coli
    Cecilia M Abe
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
    FEMS Immunol Med Microbiol 52:397-406. 2008
    To analyze whether Escherichia coli strains that cause urinary tract infections (UPEC) share virulence characteristics with the diarrheagenic E...
  92. pmc Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli
    Dennis J Horvath
    Center for Microbial Pathogenesis, Research Institute at Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Microbes Infect 13:426-37. 2011
    ..Thus, morphological plasticity can be viewed as a distinct class of mechanism used by bacterial pathogens to subvert host immunity...
  93. ncbi Asymptomatic bacteriuria and symptomatic urinary tract infections during pregnancy
    Amanda M Macejko
    Department of Urology, Northwestern University, 303 East Chicago Avenue, Tarry 16 703, Chicago, IL 60611, USA
    Urol Clin North Am 34:35-42. 2007
    b>Urinary tract infections are common complications of pregnancy; upper tract infections in particular may lead to significant morbidity for both the mother and fetus...
  94. ncbi Extended-spectrum β-lactamase-producing Gram-negative pathogens in community-acquired urinary tract infections: an increasing challenge for antimicrobial therapy
    S Meier
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Infection 39:333-40. 2011
    Extended-spectrum β-lactamases (ESBLs) are an increasing challenge in the treatment of urinary tract infections (UTIs), and also in the community...
  95. pmc Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection
    Kimberly A Kline
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Infect Immun 79:3588-95. 2011
    ..These studies define several basic molecular and cellular events characterizing GBS UTI in an animal model, showing that GBS participates simultaneously in the activation and suppression of host immune responses in the urinary tract...
  96. ncbi [Summary of the practice guideline 'Urinary-tract infections' (second revision) from the Dutch College of General Practitioners]
    B van Pinxteren
    Nederlands Huisartsen Genootschap, afd Richtlijnontwikkeling en Wetenschap, Postbus 3231, 3502 GE Utrecht
    Ned Tijdschr Geneeskd 150:718-22. 2006
    ..In addition to antibiotic prophylaxis, cranberry products may be of value in the prevention of recurrent urinary-tract infections...
  97. pmc The biomechanical properties of E. coli pili for urinary tract attachment reflect the host environment
    Magnus Andersson
    Department of Physics, Umea University, Umea, Sweden
    Biophys J 93:3008-14. 2007
    ..Our findings highlight functions that are believed to be of importance for the bacterial ability to sustain a basic antimicrobial mechanism of the host and for bacterial colonization...
  98. pmc Community transmission in the United States of a CTX-M-15-producing sequence type ST131 Escherichia coli strain resulting in death
    Robert C Owens
    Division of Infectious Diseases, Department of Medicine, Maine Medical Center, Portland, Maine, USA
    J Clin Microbiol 49:3406-8. 2011
    ..Susceptibility results (reported on day 4) showed resistance to the initially selected regimen...
  99. ncbi Lactobacillus by-products inhibit the growth and virulence of uropathogenic Escherichia coli
    P A Cadieux
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    J Physiol Pharmacol 60:13-8. 2009
    ..Our findings indicate that compounds secreted by lactobacilli likely protect the urogenital tract from UPEC colonization and infection by inhibiting growth, inducing stress and downregulating proteins critical for host attachment...
  100. pmc Urethral catheters: can we reduce use?
    Pieter J Van den Broek
    Leiden University Medical Centre, Department of Infectious Diseases, Leiden, The Netherlands
    BMC Urol 11:10. 2011
    Indwelling urinary catheters are the main cause of healthcare-associated urinary tract infections. It can be expected that reduction of the use of urinary catheters will lead to decreased numbers of urinary tract infection.
  101. ncbi Fosfomycin tromethamine as second agent for the treatment of acute, uncomplicated urinary tract infections in adult female patients in The Netherlands?
    B J Knottnerus
    Department of General Practice, Academic Medical Centre, Amsterdam, The Netherlands
    J Antimicrob Chemother 62:356-9. 2008
    Uncomplicated urinary tract infections (UTIs) are common among female patients...

Research Grants74

  1. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..lung infections, deep wound healing, the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic middle ear infections...
  2. Molecular Basis of E. coli Adhesins in Bladder Disorders
    Scott J Hultgren; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Over 15 million women suffer from urinary tract infections (UTI) annually in the U.S., ~85% of which are caused by uropathogenic Escherichia coli (UPEC)...
  3. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..In addition, A. baumannii biofilms have been implicated in cystic fibrosis, periodontitis and urinary tract infections, due to the bacteria's ability to colonize indwelling medical devices...
  4. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..Foley catheter made from a proprietary polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release...
  5. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..Stenotrophomonas, which are prevalent in severe nosocomial infections, such as pneumonia, bacteremia and urinary tract infections. Multidrug resistance is increasing among Gr(-) nonfermenters, and as a last resort, polymyxins such as ..
  6. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..a membrane-lytic toxin, hemolysin (Hly), are often co- expressed by Escherichia coli strains that cause urinary tract infections (UTIs), i.e., cystitis or pyelonephritis, or acute prostatitis...
  7. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..In pregnancy, GBS can cause urinary tract infections, chorioamnionitis, postpartum wound infection, pyelonephritis, sepsis, and rarely meningitis...
  8. Effect of D-cycloserine on treatment of PTSD in youth
    Michael S Scheeringa; Fiscal Year: 2010
    ..D-cycloserine (DCS), an antibiotic used to treat tuberculosis and urinary tract infections, is a partial agonist at the glycine modulatory site of the N-methyl- D-aspartic acid (NMDA) receptor...
  9. Determinants of Telomere Length in Chronic SCI: A Pilot Study
    Eric Garshick; Fiscal Year: 2012
    ..spinal cord injury (lac of exercise, obesity, chronic or recurrent inflammation from skin ulcers, and urinary tract infections) as well as in persons with cardiovascular and pulmonary diseases...
  10. Maternal genitourinary infections and adverse perinatal outcomes
    Abdullah Hel Baqui; Fiscal Year: 2013
    ..by applicant): Maternal genitourinary (GU) infections, particularly bacterial vaginosis (BV) and urinary tract infections (UTI) are common but inadequately quantified in low-middle income countries...
  11. Transcriptional mechanisms of lower urinary tract development
    Gerald Mingin; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Cloacal anomalies can cause chronic urinary tract infections, obstruction, renal failure, incontinence and poor self esteem...
  12. Synchrotron imaging of crystalline biofilms in urinary catheters
    Aaron I Packman; Fiscal Year: 2010
    ..Proteus is an extremely common pathogen in urinary tract infections, and is particularly problematic in patients subject to long-term urinary catheterization. P...
  13. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
    ..coli (ExPEC) strains, including urinary tract infections (UTIs), newborn meningitis (NBM), abdominal sepsis, and septicemia, result in significant morbidity, ..
  14. BIOGENESIS AND INHIBITION OF BIOFILM-ASSOCIATED BACTERIAL AMYLOID
    Scott J Hultgren; Fiscal Year: 2013
    ..These include urinary tract infections (UTIs), chronic skin infections, otitis media and cystic fibrosis lung infections...
  15. Micro-patterned surfaces for reducing the risk of catheter-associated UTI
    SHRAVANTHI REDDY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Catheter-associated urinary tract infections (CAUTI) are the most common hospital- acquired infections, accounting for over one million cases and hospital costs of more than $500 million each year in ..
  16. Deciphering ExPEC Virulence Mechanisms
    Matthew A Mulvey; Fiscal Year: 2012
    ..Extraintestinal pathogenic Escherichia coli (ExPEC) cause a diverse array of diseases including urinary tract infections, sepsis, and neonatal meningitis. These infections affect 6.7 to 8...
  17. Genetic Variations and Development of Vesicoureteral Reflux and Sequelae
    DAVID SULLIVAN HAINS; Fiscal Year: 2010
    ..while others develop renal scarring, hypertension and chronic kidney disease, usually following recurrent urinary tract infections (UTIs)...
  18. Rapid Point-of-Care Test Kit for the Detection of Bacteriuria Calibrated for Imme
    MARK GEISBERG; Fiscal Year: 2010
    ..of a rapid point-of-care test kit for the direct measurement of bacteriuria as a diagnostic for urinary tract infections (UTIs)...
  19. Novel virulence and exoenzyme regulators
    ROBERT M SHANKS; Fiscal Year: 2013
    ..also causes many hospital acquired infections including pneumonia, endocarditis, bacteremia and urinary tract infections that are commonly resistant to current antibiotics and whose outcomes are associated with significant ..
  20. An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility Testing
    VINCENT JEN JR GAU; Fiscal Year: 2013
    ..Biochip for Point of Care Pathogen Identification (U01 AI082457), for rapid molecular diagnosis urinary tract infections (UTI) using electrochemical biosensors integrated with microfluidics...
  21. Corticosteroids for Children with Febrile Urinary Tract Infections
    Nader Shaikh; Fiscal Year: 2013
    ....
  22. Vesicle Trafficking and Bacteria Invasion
    Yehia Daaka; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infections (UTI) are among the most common serious pathogenic infections in the Western world. UTIs affect infants, children, and the elderly, but females are particularly at higher risk...
  23. TeleWellness Solutions for Chronic Conditions
    EDMUND FRANK LOPRESTI; Fiscal Year: 2013
    ..including preventable hospitalizations, emergency room visits and secondary conditions such as wounds, urinary tract infections, pneumonia, and sepsis...
  24. A Novel Surface Sensing Pathway in Proteus mirabilis
    Philip N Rather; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infections, including prostatitis and infectious urinary stones, affect a large percentage of our veteran population...
  25. Delayed Onset of Biofilm Formation and CAUTI with Superhydrophobic Catheters
    Sanjiv Lalwani; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Catheter-associated urinary tract infections (CAUTI) occur in >40&of the 21-50% patients that are administered indwelling catheters, annually costing a staggering $421-$451 million in medical ..
  26. Disposable Valved Intraurethral Catheter Feasibility
    Harvey D Homan; Fiscal Year: 2010
    ..The SurinateTM catheterization system offers solutions to the problems of quality of life, urinary tract infections, and substantial reliance on healthcare workers associated with the existing catheters...
  27. Producing micturition by combined afferent and effernet electrical stimulation
    Kenneth J Gustafson; Fiscal Year: 2010
    ..These events can lead to urinary tract infections, incontinence and vesico-ureteral reflux with ensuing kidney damage...
  28. Multi-disciplinary Training in Benign Urology
    Hunter Wessells; Fiscal Year: 2013
    ..6 billion dollars in annual healthcare expenditures.1 Urinary tract infections contribute an additional 2.47 billion dollars in direct costs...
  29. Bacterial Survival in the Mammalian Urothelium
    JOSEPH PALERMO; Fiscal Year: 2010
    b>Urinary tract infections (UTIs) are the second most common infectious disease in the United States and result in medical expenditures exceeding one billion dollars annually...
  30. Paracrine Regulation of BPH Pathogeneis
    SIMON HAYWARD; Fiscal Year: 2009
    ..dribbling and, more seriously it can cause renal insufficiency (with rising serum creatinine), frequent urinary tract infections and urosepsis due to insufficient urinary draining...
  31. Regulation of Pseudomonas aeruginosa type III secretion
    Timothy L Yahr; Fiscal Year: 2012
    ..is an opportunistic pathogen commonly isolated from patients with cystic fibrosis, nosocomial pneumonias, urinary tract infections, or severe burns. A primary determinant of P. aeruginosa virulence is a type III secretion system (T3SS)...
  32. Paracrine Regulation of BPH Pathogenesis
    Simon W Hayward; Fiscal Year: 2013
    ..dribbling and, more seriously it can cause renal insufficiency (with rising serum creatinine), frequent urinary tract infections and urosepsis due to insufficient urinary draining...
  33. CHAPERONE ASSISTED PILI ASSEMBLY IN PATHOGENIC E COLI
    Scott J Hultgren; Fiscal Year: 2013
    ..For example, pili are critical in the ability of uropathogenic E. coli to cause urinary tract infections (UTIs)...
  34. Host-mediated zinc sequestration during Acinetobacter baumannii infection
    Eric P Skaar; Fiscal Year: 2013
    ..baumannii is an important nosocomial pathogen that causes a range of diseases, including respiratory and urinary tract infections, meningitis, endocarditis, wound infections, and bacteremia. In fact, A...
  35. THE OUTER MEMBRANE AS A VIRULENCE PLATFORM
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..Our original work demonstrated the importance of SurA in the pathogenesis of urinary tract infections caused by uropathogenic Escherichia coli (UPEC)...
  36. Validating targets in p. aeruginosa type III secretion using chemical probes
    Donald T Moir; Fiscal Year: 2013
    ..g. VAP, bacteremia, urinary tract infections)...
  37. Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
    JAMES CARTER RICE; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Urinary tract infections (UTIs) are the most common infection in the kidney transplant patient and are associated with a poor ..
  38. Delineating the importance of intracellular tissue occupation by Uropathogenic E.
    DREW JOEL SCHWARTZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infections (UTIs) are among the most common bacterial infections, accounting for tremendous morbidity and healthcare costs...
  39. Development of a Live Combinational Microbicide for Women
    Qiang Xu; Fiscal Year: 2010
    ..presently undergoing phase II clinical trials to examine its safety and efficacy in preventing recurrent urinary tract infections (UTIs) and bacterial vaginosis (BV)...
  40. Effects of vitamin D and omega-3 fatty acids on infectious diseases and hCAP18
    Carlos A Camargo; Fiscal Year: 2013
    ..Secondary aims will examine several other types of infections (pneumonia &influenza, urinary tract infections, skin, any antimicrobial-treated infection, infection-related hospitalizations/sepsis), which we will ..
  41. NMR studies of heterocyclization and epimerization in yersiniabactin synthesis
    DOMINIQUE PASCAL FRUEH; Fiscal Year: 2013
    ..enterocolitica, a food pathogen, and uropathogenic E. coli, responsible for urinary tract infections. Our results will contribute to understanding the molecular logic employed by these pathogens during ..
  42. Urinary metabolites of cranberry that protect against bladder cancer
    Jeevan Kumar Prasain; Fiscal Year: 2010
    ..are rich in flavonoids and it is well known that cranberry juice is helpful in treating and preventing urinary tract infections (UTIs) of E. coli...
  43. Contribution of Novel Frimbriae to Proteus Mirabilis Virulence
    Melanie M Pearson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infections are one of the most common bacterial infections in the U.S...
  44. Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
    Shahriar Mobashery; Fiscal Year: 2013
    ..Enterococci are the leading cause of nosocomial bacteremia, surgical wound infections, and urinary tract infections. Vancomycin-resistant enterococci (VRE) accounts for >25% of the enterococci hospital-acquired ..
  45. Biomarkers for Acute Pyelonephrititis in Children
    Nader Shaikh; Fiscal Year: 2011
    ..This approach could lead to significant reductions in the use of antibiotics and the exposure to radiation in children with urinary tract infections.
  46. The Recombinase FimX: Role in type 1 pili regulation and E. coli-induced cystitis
    Patrick C Seed; Fiscal Year: 2010
    ..coli urinary tract infections. In Aim 1 of this proposal, we will use a combination of molecular epidemiology, genetics, and animal ..
  47. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..of interactions between antibiotics and cranberry juice is of critical importance to a patients with urinary tract infections (UTI)...
  48. Neural Prosthetic Control of Continence and Micturition
    Warren M Grill; Fiscal Year: 2013
    ..dangerous rises in blood pressure, incontinence which contributes to skin breakdown, as well as frequent urinary tract infections. Loss of bladder control also has profound social impact and leads to decreased quality of life, as well ..
  49. Caveolae Mediated Bacterial Uptake in the Urinary Tract
    Soman N Abraham; Fiscal Year: 2010
    Uropathogenic E.coli (UPEC) account for over 80% of urinary tract infections (UTIs). It is now known invasion of the bladder epithelial cells (BECs) is a critical initiating step in UTIs...
  50. Molecular Pathogenesis of Klebsiella Pneumoniae
    Steven Clegg; Fiscal Year: 2010
    Klebsiella pneumoniae is an opportunistic pathogen frequently implicated in respiratory and urinary tract infections of hospitalized patients...
  51. RATIONAL DESIGN OF MANNOSIDES FOR INHIBITION OF FIMH AND TREATMENT OF UTI
    Scott J Hultgren; Fiscal Year: 2010
    ..FimH adhesin inhibitors will greatly enhance our efforts to find alternative strategies for treatment of urinary tract infections, one of the most common infections in humans...
  52. Rapid, sensitive and labor-free immunoassays for sepsis based on magnetic nanoflu
    Hur Koser; Fiscal Year: 2013
    ..in patient treatment - such as the widespread use of broad-spectrum antibiotics with sepsis and urinary tract infections - that contributes to increased costs, longer hospitalization times and the emergence of drug resistant ..
  53. Models of hospital-acquired conditions and readmission: defining at-risk patients
    Laurence F McMahon; Fiscal Year: 2013
    ..of our recently constructed risk-adjusted claims-based model for complications of pressure ulcers and urinary tract infections as HACs after enhancement with HRS patient-specific measures of functional status, mobility, and social ..
  54. Differences in infecting and colonizing Enterobacteriaceae from short-course vs s
    Scott J Weissman; Fiscal Year: 2013
    ..molecular analysis of bacterial isolates recovered as part of the SCOUT Study ("Short Course Therapy for Urinary Tract Infections in Children")...
  55. Mechanism of the Usher in Assembly and Secretion of Pili
    David G Thanassi; Fiscal Year: 2013
    ..are the P and type 1 pili expressed by uropathogenic Escherichia coli, the primary causative agent of urinary tract infections. P and type 1 pili are critical virulence factors, allowing binding and colonization of the kidney and ..
  56. Reducing Antimicrobial Use Associated with Ventilator Associated Pneumonia and Ca
    SARA ELIZABETH COSGROVE; Fiscal Year: 2010
    ..for both the diagnosis and treatment of ventilator-associated pneumonia (VAP) and catheter- associated urinary tract infections (CAUTI) that reduce inappropriate antimicrobial use and enhanced patient outcomes...
  57. Small molecule inhibitors of bacterial iron acquisition systems
    Harry L Mobley; Fiscal Year: 2013
    ..Lack of such new treatments will result in urinary tract infections (UTI) with multiply antibiotic-resistant strains that are untreatable...
  58. Rapid Point-of-Care Test to Detect Bacteriuria &Confirm Urinary Tract Infection
    MARK GEISBERG; Fiscal Year: 2012
    ..of a rapid point-of-care test kit for the direct measurement of bacteriuria as a diagnostic for urinary tract infections (UTIs)...
  59. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2013
    ..We found that the THP KO mice are highly prone to experimental urinary tract infections by type 1-fimbriated E...
  60. Prevention of Nosocomial Infections and Cost Effectiveness in Nursing Homes
    Patricia W Stone; Fiscal Year: 2013
    ..Our aims are: 1) Describe the incidence of HAI (pneumonia, sepsis, urinary tract infections, wound infections and MDRO infections/colonization) in NHs across the nation and associated state level ..
  61. ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTION
    DAVID ALAN HUNSTAD; Fiscal Year: 2013
    ..b>Urinary tract infections (UTIs), a major source of morbidity and medical costs worldwide, are caused primarily by uropathogenic ..
  62. ATG16L1 AND MOLECULAR REGULATION OF BACTERIAL PERSISTENCE
    Indira U Mysorekar; Fiscal Year: 2013
    ..reservoirs in membrane-bound compartments within the bladder wall and causes frequent and recurrent urinary tract infections (UTIs)...
  63. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..spectrum of the pyrrhocoricin analogs, the urgent need for new antimicrobial compounds to treat human urinary tract infections (UTI) and the generally observable tissue distribution and renal clearance of peptidic drugs suggest that ..
  64. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott Hultgren; Fiscal Year: 2007
    b>Urinary tract infections (UTIs) are among the most common bacterial infections, with symptoms that can include dysuria, urgency and frequency of urination, flank pain and fever...
  65. GU Infection Self-Diagnosis for Deployed Military Women
    Nancy Ryan Wenger; Fiscal Year: 2004
    ..or unacceptable health care resources for women increase women's risk for development of vaginitis and urinary tract infections (UTI)...
  66. Characterization of Hemolysin A from Proteus mirabilis
    Todd Weaver; Fiscal Year: 2004
    ..species are second only to Escherichia coli as the most common causative agent of Gram-negative based urinary tract infections and many harbor several virulence factors that provide inherent uropathogenicity...
  67. COATING OF URINARY PROTHESES TO PREVENT ENCRUSTATION
    Harmeet Sidhu; Fiscal Year: 2000
    ..from encrustation and bacterial adhesion that increases the risk for blockage of the device as well as urinary tract infections. Important in these events is the ability of microorganisms to attach to the biomaterial and form ..
  68. MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIA
    Milton Saier; Fiscal Year: 2000
    ..such as Escherichia coli and Salmonella species are principal causative agents of diarrhea, dysentery, urinary tract infections, meningitis in children, septicemia, enteric fevers, an pneumonia...
  69. DNA METHYLATION AND PILI GENE REGULATION
    David Low; Fiscal Year: 2006
    ..an essential virulence determinant of UPEC, this work has direct application to addressing the problem of urinary tract infections. This work will serve as a paradigm to understand how DNA methylation patterns control heritable gene ..
  70. BACTERIAL UREASE IN UTI
    HARRY MOBLEY; Fiscal Year: 2000
    b>Urinary tract infections are the most frequently diagnosed kidney and urological disorders. While E. coli is the most common isolate in normal individuals, those with complicated urinary tracts, i.e...
  71. MOLECULAR DISSECTION OF CONGENITAL NEPHROGENIC DI
    ROBERT WILDIN; Fiscal Year: 2000
    ..may cause permanent anatomic dilatation of the urinary tract structures, increasing the likelihood of urinary tract infections and traumatic rupture. Renal failure may also be a late complication...
  72. VIRUL FACTORS OF UROPATH ESCHERICHIA COLI
    Peter Redford; Fiscal Year: 2003
    Escherichia coli is the most common cause of community-acquired urinary tract infections, resulting in an estimated eight million physician visits a year in the United States. It is also a leading cause of nosocomial infections...
  73. Intra-species regulatory functions of fsr
    Satish Pillai; Fiscal Year: 2004
    Enterococcus faecalis is a leading cause of endocarditis, nosocomial bacteremia and urinary tract infections. Two characteristics contributing to the difficulty in treating enterococcal infections are (1) tolerance to beta- lactam ..
  74. BACTERIAL INTERACTIONS WITH THE BLADDER MUCOSA
    Matthew Mulvey; Fiscal Year: 2002
    ..b>Urinary tract infections (UTIs) affect a large proportion of the world population and account for significant morbidity and high ..