soft tissue infections

Summary

Summary: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)

Top Publications

  1. pmc Staphylococcus lugdunensis, a common cause of skin and soft tissue infections in the community
    Sidsel Böcher
    Department of Clinical Microbiology, Viborg Hospital, Viborg, Denmark
    J Clin Microbiol 47:946-50. 2009
  2. ncbi Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
    Gary J Moet
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 57:7-13. 2007
  3. ncbi Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010
    Michael L Landrum
    Infectious Disease Service, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA
    JAMA 308:50-9. 2012
  4. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
  5. pmc Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus USA300 clone
    Jennifer K Johnson
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Emerg Infect Dis 13:1195-200. 2007
  6. ncbi National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections
    Adam L Hersh
    Department of Pediatrics, University of California, San Francisco, 3333 California St, San Francisco, CA 94143 0936, USA
    Arch Intern Med 168:1585-91. 2008
  7. ncbi Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus
    Daniel J Pallin
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Ann Emerg Med 51:291-8. 2008
  8. ncbi Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus--an emerging problem for the management of skin and soft tissue infections
    E Anne Eady
    School of Biochemistry and Molecular Biology, University of Leeds, UK
    Curr Opin Infect Dis 16:103-24. 2003
  9. ncbi Epidemiology and molecular characteristics of community-associated methicillin-resistant and methicillin-susceptible Staphylococcus aureus from skin/soft tissue infections in a children's hospital in Beijing, China
    Dejing Wu
    Beijing Children s Hospital, Capital Medical University, Beijing 100045, China
    Diagn Microbiol Infect Dis 67:1-8. 2010
  10. pmc Trends in US hospital admissions for skin and soft tissue infections
    John Edelsberg
    Policy Analysis Inc, Brookline, Massachusetts 02445, USA
    Emerg Infect Dis 15:1516-8. 2009

Detail Information

Publications338 found, 100 shown here

  1. pmc Staphylococcus lugdunensis, a common cause of skin and soft tissue infections in the community
    Sidsel Böcher
    Department of Clinical Microbiology, Viborg Hospital, Viborg, Denmark
    J Clin Microbiol 47:946-50. 2009
    ..S. lugdunensis should be accepted as a significant pathogen in SSTI and should be looked for in all routine bacteriological examinations, and clinicians should be acquainted with the name and the pathology of the bacterium...
  2. ncbi Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
    Gary J Moet
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 57:7-13. 2007
    The morbidity and cost for cure associated with skin and soft tissue infections (SSTIs) have recently become more complicated because of the increasing prevalence of multidrug-resistant pathogens associated with this healthcare problem...
  3. ncbi Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010
    Michael L Landrum
    Infectious Disease Service, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA
    JAMA 308:50-9. 2012
    ..Rates of hospital-onset methicillin-resistant Staphylococcus aureus (MRSA) infections are reported as decreasing, but recent rates of community-onset S. aureus infections are less known...
  4. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
    ..Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA...
  5. pmc Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus USA300 clone
    Jennifer K Johnson
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Emerg Infect Dis 13:1195-200. 2007
    ..We studied MRSA infections and overall skin and soft tissue infections (SSTIs) in outpatients receiving care at the Baltimore Veterans Affairs Medical Center Emergency Care ..
  6. ncbi National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections
    Adam L Hersh
    Department of Pediatrics, University of California, San Francisco, 3333 California St, San Francisco, CA 94143 0936, USA
    Arch Intern Med 168:1585-91. 2008
    ..It is unknown whether this development has affected the national rate of visits to primary care practices and emergency departments (EDs) and whether changes in antibiotic prescribing have occurred...
  7. ncbi Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus
    Daniel J Pallin
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Ann Emerg Med 51:291-8. 2008
    Test the hypotheses that emergency department (ED) visits for skin and soft tissue infections became more frequent during the emergence of community-associated methicillin-resistant Staphylococcus aureus (MRSA), and that antibiotics ..
  8. ncbi Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus--an emerging problem for the management of skin and soft tissue infections
    E Anne Eady
    School of Biochemistry and Molecular Biology, University of Leeds, UK
    Curr Opin Infect Dis 16:103-24. 2003
    In the community non-localized or deep staphylococcal skin and soft tissue infections are typically managed with beta-lactamase stable penicillins...
  9. ncbi Epidemiology and molecular characteristics of community-associated methicillin-resistant and methicillin-susceptible Staphylococcus aureus from skin/soft tissue infections in a children's hospital in Beijing, China
    Dejing Wu
    Beijing Children s Hospital, Capital Medical University, Beijing 100045, China
    Diagn Microbiol Infect Dis 67:1-8. 2010
    ..aureus (MSSA) from children with skin and soft tissue infections (SSTIs) in Beijing, China, prospective community-acquired S...
  10. pmc Trends in US hospital admissions for skin and soft tissue infections
    John Edelsberg
    Policy Analysis Inc, Brookline, Massachusetts 02445, USA
    Emerg Infect Dis 15:1516-8. 2009
    ..and Utilization Project National Inpatient Sample, we found that total hospital admissions for skin and soft tissue infections increased by 29% during 2000-2004; admissions for pneumonia were largely unchanged...
  11. ncbi Practice guidelines for the diagnosis and management of skin and soft-tissue infections
    Dennis L Stevens
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    Clin Infect Dis 41:1373-406. 2005
  12. ncbi Severity assessment of skin and soft tissue infections: cohort study of management and outcomes for hospitalized patients
    Charis Marwick
    Quality, Safety and Informatics Research Group, Division of Clinical and Population Sciences and Education, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF, Scotland, UK
    J Antimicrob Chemother 66:387-97. 2011
    Skin and soft tissue infections (SSTIs) are caused by bacterial invasion of the skin and underlying soft tissues and can present with a wide spectrum of signs, symptoms and illness severity...
  13. ncbi Panton-Valentine leukocidin associated staphylococcal disease: a cross-sectional study at a London hospital, England
    L J Shallcross
    Research Department of Infection and Population Health, University College London, UK
    Clin Microbiol Infect 16:1644-8. 2010
    ..Community-onset PVL-associated disease is common in the UK and mainly causes skin and soft tissue infections that do not require admission to hospital...
  14. pmc Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes
    Grace Soong
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Infect Dis 205:1571-9. 2012
    ..These studies suggest that pharmacological interruption of specific keratinocyte signaling cascades as well as targeting the Hla might prevent invasive skin infection by staphylococci...
  15. pmc Effectiveness of measures to eradicate Staphylococcus aureus carriage in patients with community-associated skin and soft-tissue infections: a randomized trial
    Stephanie A Fritz
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Infect Control Hosp Epidemiol 32:872-80. 2011
    ..Despite a paucity of evidence, decolonization measures are prescribed for outpatients with recurrent Staphylococcus aureus skin and soft-tissue infection (SSTI)...
  16. pmc Epidemiology and outcomes of complicated skin and soft tissue infections in hospitalized patients
    Marcus J Zervos
    Henry Ford Health System, Detroit, Michigan, USA
    J Clin Microbiol 50:238-45. 2012
    Complicated skin and soft tissue infections (cSSTIs) are among the most rapidly increasing reasons for hospitalization...
  17. pmc Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections
    P Prokocimer
    Trius Therapeutics, Inc, 6310 Nancy Ridge Drive, Suite 105, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 55:583-92. 2011
    ..9 liters (35.7%). Results of this study show a high degree of efficacy at all three dose levels without significant differences in the safety profile and support the continued evaluation of TP for the treatment of cSSSI in phase 3 trials...
  18. ncbi Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost
    B A Lipsky
    VA Puget Sound Health Care System, General Internal Medicine S 111 PCC, University of Washington, 1660 S Columbian Way, Seattle, WA, USA
    Diabetologia 53:914-23. 2010
    Skin and soft tissue infections (SSTIs) cause substantial morbidity in persons with diabetes. There are few data on pathogens or risk factors associated with important outcomes in diabetic patients hospitalised with SSTIs.
  19. ncbi Comparison of Staphylococcus aureus from skin and soft-tissue infections in US emergency department patients, 2004 and 2008
    David A Talan
    Department of Emergency Medicine
    Clin Infect Dis 53:144-9. 2011
    ..Little information exists regarding trends in MRSA prevalence and molecular characteristics or regarding antimicrobial susceptibility profiles of S. aureus isolates...
  20. ncbi The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections
    Chin Ho Wong
    Department of Plastic Surgery, Singapore General Hospital, Singapore
    Crit Care Med 32:1535-41. 2004
    ..We aimed to develop a novel diagnostic scoring system for distinguishing necrotizing fasciitis from other soft tissue infections based on laboratory tests routinely performed for the evaluation of severe soft tissue infections: the ..
  21. pmc Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin
    Binh An Diep
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720, USA
    J Clin Microbiol 42:2080-4. 2004
    ..0001). There is evidence of clonal replacement over the period from 1999 to 2002, with one of these two clonal groups being supplanted by the other...
  22. ncbi Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections at a public hospital: do public housing and incarceration amplify transmission?
    Bala Hota
    Department of Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Intern Med 167:1026-33. 2007
    ..Understanding the epidemiology of CA-MRSA is critical for developing control measures...
  23. ncbi Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections
    Mark D King
    Emory University School of Medicine and Grady Memorial Hospital, Atlanta, Georgia 30303, USA
    Ann Intern Med 144:309-17. 2006
    ..Studies have shown that community-acquired methicillin-resistant Staphylococcus aureus (MRSA) causes S. aureus skin and soft-tissue infection in selected populations...
  24. ncbi Recurrent skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus requiring operative debridement
    Pranavi Sreeramoju
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Surg 201:216-20. 2011
    The aim of this study was to examine clinical factors associated with the recurrence of community-onset skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus.
  25. ncbi Diagnosis and management of Staphylococcus aureus infections of the skin and soft tissue
    S Roberts
    Department of Microbiology, LabPlus, Auckland District Health Board, Auckland, New Zealand
    Intern Med J 35:S97-105. 2005
    ..There are few studies that have critically appraised the use of antibiotics in skin and soft tissue infections, and most guidelines are based on expert opinion...
  26. ncbi Increasing incidence and sociodemographic variation in community-onset Staphylococcus aureus skin and soft tissue infections in New Zealand children
    Deborah A Williamson
    Department of Clinical Microbiology, Auckland City Hospital, Auckland, New Zealand
    Pediatr Infect Dis J 32:923-5. 2013
    ..A total of 1860 children were included. There was significant sociodemographic disparity, with the incidence disproportionately higher in Maori and Pacific Island children residing in deprived areas. ..
  27. ncbi Characterization of methicillin-resistant Staphylococcus aureus from skin and soft tissue infections in patients in Nairobi, Kenya
    Edward K Maina
    Centre for Microbiology Research, Kenya Medical Research Institute, P O Box 19464 00202 Nairobi, Kenya
    Int J Infect Dis 17:e115-9. 2013
    Skin and soft tissue infections (SSTIs) are among the most common infectious diseases and a frequent cause of hospital visits...
  28. ncbi Antibacterial resistance, genes encoding toxins and genetic background among Staphylococcus aureus isolated from community-acquired skin and soft tissue infections in France: a national prospective survey
    B Lamy
    Department of Bacteriology, Hopital Arnaud de Villeneuve, 34295, Montpellier, France
    Eur J Clin Microbiol Infect Dis 31:1279-84. 2012
    ..MRSA strains isolated from putative CA-SSTIs exhibited a genetic and phenotypic background of hospital-acquired (HA) clones. National survey should be continued, in order to monitor the emergence of virulent clones...
  29. ncbi High prevalence of ST121 in community-associated methicillin-susceptible Staphylococcus aureus lineages responsible for skin and soft tissue infections in Portuguese children
    T Conceição
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal
    Eur J Clin Microbiol Infect Dis 30:293-7. 2011
    ..30 children attending the pediatric emergency department of a central hospital in Lisbon due to skin and soft tissue infections. Molecular characterization identified seven clonal lineages among the 35 methicillin-susceptible S...
  30. pmc The epidemiology of hematogenous vertebral osteomyelitis: a cohort study in a tertiary care hospital
    Kavita P Bhavan
    Division of Infectious Diseases, Washington University School of Medicine, St, Louis, MO, USA
    BMC Infect Dis 10:158. 2010
    ..Limited data exist regarding hematogenous vertebral osteomyelitis. Our objective was to describe the epidemiology and management of hematogenous vertebral osteomyelitis...
  31. pmc Comparative effectiveness of antibiotic treatment strategies for pediatric skin and soft-tissue infections
    Derek J Williams
    Department of Pediatrics, School of Medicine and Monroe Carell Jr Children s Hospital, Vanderbilt University, Nashville, Tennessee 37232 2573, USA
    Pediatrics 128:e479-87. 2011
    ..To compare the effectiveness of clindamycin, trimethoprim-sulfamethoxazole, and β-lactams for the treatment of pediatric skin and soft-tissue infections (SSTIs)...
  32. pmc Clinical and molecular characteristics of invasive and noninvasive skin and soft tissue infections caused by group A Streptococcus
    Jiun Nong Lin
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Clin Microbiol 49:3632-7. 2011
    The severity of skin and soft tissue infections caused by group A Streptococcus (GAS) is variable, and there are only a limited number of studies evaluating the characteristics of these infections in the literature...
  33. ncbi Infections due to rapidly growing mycobacteria
    Mary A De Groote
    University of Colorado, Boulder, Colorado, USA
    Clin Infect Dis 42:1756-63. 2006
    ..Here, we focus on the members of the rapidly growing mycobacteria because of their emerging importance in both sporadic infections and outbreak settings...
  34. doi Clinical decisions. Management of skin and soft-tissue infection--polling results
    Sarah P Hammond
    Division of Infectious Diseases, Brigham and Women s Hospital, USA
    N Engl J Med 359:e20. 2008
  35. pmc Population-based study of the increased incidence of skin and soft tissue infections and associated antimicrobial use
    Fawziah Marra
    University of British Columbia, Vancouver, British Columbia, Canada
    Antimicrob Agents Chemother 56:6243-9. 2012
    ..Canada on physician visits, incision-and-drainage procedures, and antibiotic prescribing for skin and soft tissue infections (SSTI)...
  36. ncbi ABSCESS: applied bedside sonography for convenient evaluation of superficial soft tissue infections
    Benjamin T Squire
    Department of Emergency Medicine, University of California, Irvine, Orange, CA 92868, USA
    Acad Emerg Med 12:601-6. 2005
    b>Soft tissue infections are a common presenting complaint in the emergency department (ED). The authors sought to determine the utility of ED bedside ultrasonography (US) in detecting subcutaneous abscesses.
  37. ncbi Staphylococcus aureus skin and soft tissue infections at a tertiary hospital in Botswana
    Hong Truong
    Jefferson Medical College, Philadelphia, PA, USA
    S Afr Med J 101:413-6. 2011
    ..aureus isolates over time...
  38. ncbi Trends in sources of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia: data from the national mandatory surveillance of MRSA bacteraemia in England, 2006-2009
    J Wilson
    Healthcare Associated Infection and Antimicrobial Resistance Department, Health Protection Agency, London, UK
    J Hosp Infect 79:211-7. 2011
    ..These changes have occurred in the context of a general decline in the rate of MRSA bacteraemia in England since 2006...
  39. ncbi Clinical isolates of Pantone-Valentine leucocidin- and gamma-haemolysin-producing Staphylococcus aureus: prevalence and association with clinical infections
    I Mesrati
    Laboratory of Research, Resistance aux Antimicrobiens, Faculty of Medicine of Tunis, Tunis, Tunisia
    J Hosp Infect 75:265-8. 2010
    ..6%) were community-acquired. There was a strong association between pvl genes and skin and soft tissue infections, especially abscesses (60% of strains; P = 0.008) and furunculosis (55.5% of strains; P = 0.036)...
  40. pmc Prevalence, severity, and treatment of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infections in 10 medical clinics in Texas: a South Texas Ambulatory Research Network (STARNet) study
    Nicolas A Forcade
    College of Pharmacy, University of Texas, Austin, TX, USA
    J Am Board Fam Med 24:543-50. 2011
    ....
  41. ncbi Changes in community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections presenting to the pediatric emergency department: comparing 2003 to 2008
    Mia L Karamatsu
    Department of Emergency Medicine, Loma Linda University Medical Center and Children s Hospital, Loma Linda, CA 92154, USA
    Pediatr Emerg Care 28:131-5. 2012
    ....
  42. ncbi Panton-Valentine leukocidin-positive Staphylococcus aureus skin and soft tissue infections among children in an emergency department in Madrid, Spain
    M Daskalaki
    Servicio de Microbiologia, Hospital Universitario 12 de Octubre, Avenida de Cordoba sn, Madrid, Spain
    Clin Microbiol Infect 16:74-7. 2010
    ..who attended the emergency department with community-associated (CA) Staphylococcus aureus skin and soft tissue infections (SSTIs) were enrolled in the study. Seven cases of infection (13.2%) were due to methicillin-resistant S...
  43. ncbi Community-associated methicillin-resistant Staphylococcus aureus: prevalence in skin and soft tissue infections at emergency departments in the Greater Toronto Area and associated risk factors
    Heather J Adam
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    CJEM 11:439-46. 2009
    ..We assessed the prevalence, risk factors, microbiological characteristics and outcomes of CA-MRSA in patients with purulent skin and soft tissue infections (SSTIs) presenting to emergency departments (EDs) in the Greater Toronto Area.
  44. ncbi High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections
    Bradley W Frazee
    Department of Emergency Medicine, Alameda County Medical Center Highland Campus, Oakland, CA 94602, USA
    Ann Emerg Med 45:311-20. 2005
    ..methicillin-resistant Staphylococcus aureus (MRSA) among emergency department (ED) patients with skin and soft tissue infections, identify demographic and clinical variables associated with MRSA, and characterize MRSA by antimicrobial ..
  45. ncbi Necrotizing soft tissue infections: APACHE II score, dissemination, and survival
    Tuncay Yilmazlar
    Department of General Surgery, Uludag University School of Medicine, Gorukle Kampusu, Bursa, 21900, Turkey
    World J Surg 31:1858-62. 2007
    First described more than a century ago, necrotizing soft tissue infections (NSTIs) continue to cause high mortality and morbidity...
  46. ncbi Epidemiology and antibiotic susceptibility of bacteria causing skin and soft tissue infections in the USA and Europe: a guide to appropriate antimicrobial therapy
    Mark E Jones
    Focus Technologies, Dwarsdijk 30, 3612AP Tienhoven, Netherlands
    Int J Antimicrob Agents 22:406-19. 2003
    Susceptibility data for all organisms associated with a range of skin and soft tissue infections (SSTI) in hospitalised patients were studied...
  47. pmc Epidemiology and outcomes of community-associated methicillin-resistant Staphylococcus aureus infection
    S L Davis
    Henry Ford Hospital, Detroit, MI, USA
    J Clin Microbiol 45:1705-11. 2007
    ..7 to 6.9). In the community setting, the molecular characteristics of the S. aureus strains were heterogeneous. CA-MRSA infections were associated with a more adverse impact on outcome than CA-MSSA infections...
  48. ncbi Complicated skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus: epidemiology, risk factors, and presentation
    Matthew Dryden
    Microbiology and Communicable Disease, Royal Hampshire County Hospital, Winchester, Hampshire, United Kingdom
    Surg Infect (Larchmt) 9:s3-10. 2008
    Complicated skin and soft tissue infections (cSSTIs) present a challenge to healthcare providers. Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of these infections, particularly in certain countries...
  49. ncbi An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients
    David M Young
    Department of Surgery, San Francisco General Hospital, University of California, San Francisco 94110, USA
    Arch Surg 139:947-51; discussion 951-3. 2004
    A high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in soft tissue infections presents a treatment challenge.
  50. ncbi Staphylococcus aureus skin/soft-tissue infections: the impact of SCCmec type and Panton-Valentine leukocidin
    Houssein Jahamy
    Department of Medicine, St John Hospital and Medical Center, Grosse Pointe Woods, MI 48236, USA
    Scand J Infect Dis 40:601-6. 2008
    ..PVL is implicated in abscess formation but not bacteremia. Bacteremia is likely related to host condition and/or other virulence factors that were not studied...
  51. ncbi Emergence of community-acquired methicillin-resistant Staphylococcus aureus skin and soft tissue infections as a common cause of hospitalization in United States children
    Christopher R Frei
    The University of Texas at Austin, College of Pharmacy, Austin, TX 78712, USA
    J Pediatr Surg 45:1967-74. 2010
    ..Since then, possible risk factors for contracting CA-MRSA have been hypothesized, but supporting studies are limited...
  52. ncbi Predictors of clinical virulence in community-onset methicillin-resistant Staphylococcus aureus infections: the importance of USA300 and pneumonia
    Bala Hota
    Department of Medicine, Division of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA
    Clin Infect Dis 53:757-65. 2011
    ..We sought to evaluate if the USA300 strain of CO-MRSA causes more severe infections than other MRSA (ie, USA100, -500, -800, and others) strains...
  53. ncbi Epidemiological differences between the UK and Ireland versus France in Staphylococcus aureus isolates resistant to fusidic acid from community-acquired skin and soft tissue infections
    A R Larsen
    Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen, Denmark
    J Antimicrob Chemother 61:589-94. 2008
    To characterize the epidemiology of Staphylococcus aureus isolates resistant to fusidic acid isolated from patients with skin and soft tissue infections (SSTIs) in France, the UK and Ireland.
  54. pmc Molecular characterization of Staphylococcus aureus isolates causing skin and soft tissue infections (SSTIs)
    Dan Yao
    Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou325000, China
    BMC Infect Dis 10:133. 2010
    ..aureus (MRSA), is an important cause of pyogenic skin and soft tissue infections (SSTIs)...
  55. pmc Emergence and characterization of community-associated methicillin-resistant Staphyloccocus aureus infections in Denmark, 1999 to 2006
    A R Larsen
    Statens Serum Institut, National Center for Antimicrobials and Infection Control, Artillerivej 5 B 47 204, 2300 Copenhagen S, Denmark
    J Clin Microbiol 47:73-8. 2009
    ..CA-MRSA was associated with a young age, skin and soft tissue infections, and non-Danish origin. Transmission between household members was frequently reported...
  56. ncbi Efficacy and safety of linezolid versus vancomycin for the treatment of complicated skin and soft-tissue infections proven to be caused by methicillin-resistant Staphylococcus aureus
    Kamal M F Itani
    VA Boston Healthcare System and Boston University, 1400 VFW Pkwy, Boston, MA 02132, USA
    Am J Surg 199:804-16. 2010
    ..This open-label study compared oral or intravenous linezolid with intravenous vancomycin for treatment of complicated skin and soft-tissue infections (cSSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA)...
  57. pmc Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections
    D L Stevens
    Infectious Diseases Section, Veterans Administration Medical Center, Boise, Idaho, USA
    Antimicrob Agents Chemother 44:3408-13. 2000
    ..linezolid, an oxazolidinone, with those of oxacillin-dicloxacillin in patients with complicated skin and soft tissue infections. A total of 826 hospitalized adult patients were randomized to receive linezolid (600 mg intravenously [i...
  58. ncbi Treatment of complicated skin and soft tissue infections
    Addison K May
    Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Surg Infect (Larchmt) 10:467-99. 2009
    Skin and soft tissue infections (SSTIs) may produce substantial morbidity and mortality rates, particularly those classified as complicated or necrotizing.
  59. ncbi The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections
    Robert D Arbeit
    Cubist Pharmaceuticals, Lexington, Massachusetts 02421, USA
    Clin Infect Dis 38:1673-81. 2004
    ..0001). The frequency and distribution of adverse events were similar among both treatment groups. Overall, the safety and efficacy of daptomycin were comparable with conventional therapy...
  60. ncbi A severity score for complicated skin and soft tissue infections derived from phase III studies of linezolid
    Samuel Eric Wilson
    Department of Surgery, University of California Irvine, UCI Medical Center, 101 The City Dr, South Orange, CA 92868, USA
    Am J Surg 185:369-75. 2003
    ..Severity scoring systems are useful for assessing patient risk and predicting prognosis...
  61. ncbi MR imaging with ultrasmall superparamagnetic iron oxide particles in experimental soft-tissue infections in rats
    Achim H Kaim
    Department of Nuclear Medicine, University Hospital Zurich, Switzerland
    Radiology 225:808-14. 2002
    ..To investigate the feasibility of macrophage magnetic resonance (MR) imaging in rats by using an experimental soft-tissue infection model...
  62. ncbi Functional-morphologic MR imaging with ultrasmall superparamagnetic particles of iron oxide in acute and chronic soft-tissue infection: study in rats
    Achim H Kaim
    Department of Diagnostic Radiology, University Hospital Basel, Switzerland
    Radiology 227:169-74. 2003
    ....
  63. ncbi Efficacy of gaseous nitric oxide in the treatment of skin and soft tissue infections
    Abdi Ghaffari
    Wound Healing Lab, Department of Surgery, Vancouver, British Columbia, Canada
    Wound Repair Regen 15:368-77. 2007
    ....
  64. ncbi The epidemiology of and risk factors for invasive Staphylococcus aureus infections in western Sweden
    Gunnar Jacobsson
    From the Department of Infectious Diseases, Research and Development Centre, Skaraborg Hospital, Skovde, Sweden
    Scand J Infect Dis 39:6-13. 2007
    ..One- quarter of the patients had no history of fever, and one-third of the bacteraemia patients had normal white blood cell count (<10 x 10(9)/l) at presentation. All cases were of MSSA (methicillin-sensitive Staphylococcus aureus)...
  65. pmc Virulence potential of Escherichia coli isolates from skin and soft tissue infections
    Ziva Petkovsek
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia
    J Clin Microbiol 47:1811-7. 2009
    Escherichia coli strains frequently are isolated from skin and soft tissue infections (SSTI); however, their virulence potential has not yet been extensively studied. In the present study, we characterized 102 E...
  66. ncbi US hospitalizations and costs for illicit drug users with soft tissue infections
    Traci A Takahashi
    VA Puget Sound Health Care System, 1660 S Columbian Way, S 111 PCC, Seattle, WA 98108, USA
    J Behav Health Serv Res 37:508-18. 2010
    Skin and soft tissue infections (SSTIs) are common complications of illicit drug use. Studies at single, urban hospitals demonstrate high rates of emergency department visits and hospitalizations for these infections...
  67. ncbi Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010-2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study
    J Garau
    Department of Medicine, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain
    Clin Microbiol Infect 19:E377-85. 2013
    Complicated skin and soft tissue infections (cSSTI) are common and frequently require treatment in hospital. Comprehensive current data on management practices in patients hospitalized with cSSTI are limited...
  68. ncbi Daptomycin versus other antimicrobial agents for the treatment of skin and soft tissue infections: a meta-analysis
    Ioannis A Bliziotis
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Ann Pharmacother 44:97-106. 2010
    Skin and soft tissue infections (SSTIs) are common in everyday clinical practice. Daptomycin has been shown to achieve very good concentrations in skin and soft tissues.
  69. ncbi Board-certified emergency physicians' treatment of skin and soft tissue infections in the community-acquired methicillin-resistant Staphylococcus aureus era
    Frank LoVecchio
    Maricopa Medical Center, Department of Emergency Medicine, Phoenix, AZ 85008, USA
    Am J Emerg Med 27:68-70. 2009
    Emergency physicians commonly treat skin and soft tissue infections. Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become the prominent etiologic agent in these infections...
  70. ncbi Linezolid reduces length of stay and duration of intravenous treatment compared with vancomycin for complicated skin and soft tissue infections due to suspected or proven methicillin-resistant Staphylococcus aureus (MRSA)
    Kamal M F Itani
    Boston VA Health Care System and Boston University, Boston, MA, USA
    Int J Antimicrob Agents 26:442-8. 2005
    We compared the health outcomes in patients treated with linezolid or vancomycin for complicated skin and soft tissue infections (cSSTIs)...
  71. ncbi In vitro activity of daptomycin against Staphylococcus aureus and vancomycin-resistant Enterococcus faecium isolates associated with skin and soft tissue infections: first results from India
    Benu Dhawan
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 29, India
    Diagn Microbiol Infect Dis 65:196-8. 2009
    ..Daptomycin was the most active agent against both S. aureus (MIC(90), 1 microg/mL; 100% susceptible) and VREF (MIC(90), 4 microg/mL; 100% susceptible), making it an excellent therapeutic option...
  72. ncbi Safety and efficacy of daptomycin as first-line treatment for complicated skin and soft tissue infections in elderly patients: an open-label, multicentre, randomized phase IIIb trial
    Alexander Konychev
    Surgery Department, City Hospital, Ulitsa Kosinova, St Petersburg, Russia
    Drugs Aging 30:829-36. 2013
    Daptomycin has proven efficacy in patients with Gram-positive complicated skin and soft tissue infections (cSSTIs), including those caused by Staphylococcus aureus, regardless of methicillin susceptibility.
  73. pmc Soft tissue infections caused by spore-forming bacteria in injecting drug users in the United Kingdom
    M M Brett
    Food Safety Microbiology Laboratory, Health Protection Agency Specialist and Reference Microbiology Division, London, UK
    Epidemiol Infect 133:575-82. 2005
    ..Clinicians and laboratories must report such cases (or likely cases) rapidly so that clusters can be rapidly identified, in order to control disease. Prevention relies on tetanus immunization...
  74. ncbi Streptococcus pneumoniae skin and soft tissue infections: characterization of causative strains and clinical illness
    J M Garcia-Lechuz
    Department of Clinical Microbiology and Infectious Diseases HIV, Hospital General Universitario Gregorio Maranon, Dr Esquerdo 46, 28007 Madrid, Spain
    Eur J Clin Microbiol Infect Dis 26:247-53. 2007
    Streptococcus pneumoniae is an uncommon cause of skin and soft tissue infections, yet the incidence and clinical significance of its isolation in samples of skin or soft tissues in unselected hospital samples is poorly understood...
  75. ncbi Treatment of MRSA soft tissue infections: an overview
    M Morgan
    Department of Microbiology, Royal Devon and Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK
    Injury 42:S11-7. 2011
    ..emergence of new highly spreadable strains (community associated or CA-MRSA) novel presentation skin and soft tissue infections (SSTI) are being seen...
  76. ncbi Emergence of community-acquired methicillin-resistant Staphylococcus aureus soft tissue infections
    Max Olesevich
    Department of Surgery, Pediatric General Surgery, East Tennessee Children s Hospital, University of Tennessee, Knoxville, TN 37920, USA
    J Pediatr Surg 42:765-8. 2007
    ..Our objective is to describe the changing incidence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) and its treatment within East Tennessee...
  77. pmc Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york
    Anna Kaltsas
    Albert Einstein College of Medicine, Department of Medicine, Infectious Disease Division, 1300 Morris Park Ave, UL 1223, Bronx, NY 10461, USA
    J Clin Microbiol 49:2992-5. 2011
    ..aureus (MRSA) and MSSA SSTIs were comparable. In multivariable analysis, the presence of lukF-PV remained a significant predictor for incision and drainage among MSSA strains...
  78. ncbi Rates of antimicrobial resistance among common bacterial pathogens causing respiratory, blood, urine, and skin and soft tissue infections in pediatric patients
    M E Jones
    Focus Technologies, Herndon, VA 20171, USA
    Eur J Clin Microbiol Infect Dis 23:445-55. 2004
    ..4% (USA). Among isolates from blood and skin and soft tissue infections, the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) ranged from 7...
  79. ncbi [Daptomycin in complicated skin and soft tissue infections]
    José Barberán
    Unidad de Enfermedades Infecciosas, Hospital Central de Defensa Gómez Ulla, Madrid, Espana
    Enferm Infecc Microbiol Clin 30:33-7. 2012
    In recent years, Staphylococcus aureus, the most commonly identified infectious agent causing skin and soft tissue infections (SSTIs), has shown an increase in methicillin resistance and decreased susceptibility to vancomycin...
  80. ncbi Skin and soft tissue infections caused by community-associated methicillin-resistant staphylococcus aureus among children in China
    W Geng
    Beijing Children s Hospital Affiliated with the Capital Medical University, Beijing, China
    Acta Paediatr 99:575-80. 2010
    To investigate the characteristic of community-associated methicillin-resistant staphylococcus aureus (CA-MRSA) skin and soft tissue infections (SSTIs) among children in China.
  81. ncbi Complicated skin and soft tissue infection
    Matthew S Dryden
    Department of Microbiology, Royal Hampshire County Hospital, Romsey Road, Winchester SO22 5DG, UK
    J Antimicrob Chemother 65:iii35-44. 2010
    Skin and soft tissue infections (SSTIs) are common, and complicated SSTIs (cSSTIs) are the more extreme end of this clinical spectrum, encompassing a range of clinical presentations such as deep-seated infection, a requirement for ..
  82. ncbi Self-reported incidence of skin and soft tissue infections among deployed US military
    Larissa May
    Department of Emergency Medicine, The George Washington University, 2150 Pennsylvania Avenue, NW, Suite 2B, Washington, DC 20037, USA
    Travel Med Infect Dis 9:213-20. 2011
    The incidence of skin and soft tissue infections has steadily increased over the past decade, and military populations, particularly recruits, have been affected...
  83. ncbi Severe soft tissue infections of the extremities in patients admitted to an intensive care unit
    J R Zahar
    Service de Réanimation Médicale and d Immunologie Clinique, Hopital Henri Mondor, Creteil, France
    Clin Microbiol Infect 11:79-82. 2005
    ..At admission, patients with NF were more likely to have skin areas of ischaemia or necrosis, fluid-filled vesicles, and severe sepsis or septic shock...
  84. ncbi Geographic distribution of community-acquired methicillin-resistant Staphylococcus aureus soft tissue infections
    Connie J Rossini
    Department of Surgery, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA
    J Pediatr Surg 46:1089-92. 2011
    ..The goal of this study is to look at the geographic growth patterns of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in our local region and to determine if specific geographic areas are at increased risk...
  85. ncbi Changes in the classification and management of skin and soft tissue infections
    Roland Koerner
    Department of Microbiology, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK
    J Antimicrob Chemother 66:232-4. 2011
    Although skin and soft tissue infections (SSTIs) are extremely common in both primary and secondary care, there is a lack of validated evidence-based schemes for the classification of clinical presentation or severity, and there are few ..
  86. ncbi Outbreak of skin and soft tissue infections in a hospital newborn nursery in Italy due to community-acquired meticillin-resistant Staphylococcus aureus USA300 clone
    A Sanchini
    Istituto Superiore di Sanita, Rome, Italy
    J Hosp Infect 83:36-40. 2013
    ..Community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) is responsible for severe infections in previously healthy people acquired in the community in different areas of the world...
  87. ncbi Clinafloxacin versus piperacillin/tazobactam in the treatment of severe skin and soft-tissue infections in adults at a Veterans Affairs medical center
    Flora S Siami
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212 2637, USA
    Clin Ther 24:59-72. 2002
    ..Thus, there is a continuing search for reasonably safe, well-tolerated, and effective antimicrobial agents that are less susceptible to the development of resistance than older agents...
  88. ncbi Prognostic aspects, survival rate, and predisposing risk factors in patients with Fournier's gangrene and necrotizing soft tissue infections: evaluation of clinical outcome of 55 patients
    A Martinschek
    Department of Urology, Federal Armed Forces Hospital of Ulm, Ulm, Germany Martinschek web de
    Urol Int 89:173-9. 2012
    To determine predisposing or prognostic factors and mortality rates of patients with Fournier's gangrene compared to other necrotizing soft tissue infections (NSTI).
  89. pmc Mupirocin and chlorhexidine resistance in Staphylococcus aureus in patients with community-onset skin and soft tissue infections
    Stephanie A Fritz
    Departments of Pediatrics, Washington University in St Louis School of Medicine, St Louis, Missouri, USA
    Antimicrob Agents Chemother 57:559-68. 2013
    ..including mupirocin and chlorhexidine, are often prescribed to prevent Staphylococcus aureus skin and soft tissue infections (SSTI)...
  90. ncbi Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus
    Robert S Daum
    Section of Infectious Diseases, Department of Pediatrics, University of Chicago, Chicago, USA
    N Engl J Med 357:380-90. 2007
  91. ncbi Necrotizing soft tissue infections--are they different in healthy vs immunocompromised children?
    Sonia A Butterworth
    Department of Surgery, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada V6H 3V4
    J Pediatr Surg 41:935-9. 2006
    ..Necrotizing soft tissue infection (NSTI) is rare and often devastating. We sought to define our experience and determine if differences in immune status influenced outcome...
  92. ncbi Risk factors for the outcome of cirrhotic patients with soft tissue infections
    Ber Ming Liu
    Department of Emergency Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Niao Sung, Kaohsiung, Taiwan
    J Clin Gastroenterol 42:312-6. 2008
    The aims of this study were to identify risk factors that influence outcomes of cirrhotic patients with soft tissue infections and to describe specific management for such patients.
  93. ncbi Treatment and prevention of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections
    Kyle J Popovich
    Rush University Medical Center, Stroger Cook County Hospital, Chicago, Illinois, USA
    Dermatol Ther 21:167-79. 2008
    ..Although skin and soft tissue infections (SSTIs) are the most common presentation, invasive and more virulent disease has been observed...
  94. pmc Randomized, double-blind, phase II, multicenter study evaluating the safety/tolerability and efficacy of JNJ-Q2, a novel fluoroquinolone, compared with linezolid for treatment of acute bacterial skin and skin structure infection
    Paul Covington
    Furiex Pharmaceuticals Inc, 3900 Paramount Parkway, Suite 150, Morrisville, North Carolina 27560, USA
    Antimicrob Agents Chemother 55:5790-7. 2011
    ..e., lack of spread of lesions and absence of fever at 48 to 72 h), and (ii) cure rates for ABSSSI pathogens (especially MRSA) consistent with the historical literature...
  95. ncbi Management of skin and soft tissue infections in community practice before and after implementing a "best practice" approach: an Iowa Research Network (IRENE) intervention study
    Jeanette M Daly
    Department of Family Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Am Board Fam Med 24:524-33. 2011
    Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a major pathogen among skin and soft tissue infections (SSTIs). Most CA-MRSA infections are managed initially on an outpatient basis...
  96. ncbi Clinical efficacy of oral linezolid compared with intravenous vancomycin for the treatment of methicillin-resistant Staphylococcus aureus-complicated skin and soft tissue infections: a retrospective, propensity score-matched, case-control analysis
    Kamal M F Itani
    VA Boston Healthcare System and Boston University, Boston, Massachusetts 02132, USA
    Clin Ther 34:1667-73.e1. 2012
    ..open-label, comparator-controlled, multicenter, phase 4 clinical trial in adults with complicated skin and soft tissue infections (cSSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA), linezolid achieved clinical and ..
  97. ncbi Soft tissue infections of the extremities in an orthopaedic centre in the UK
    C P Charalambous
    University Department of Orthopaedics, Manchester Royal Infirmary, Manchester, UK
    J Infect 46:106-10. 2003
    To determine the spectrum, and clinical impact of acute extremity soft tissue infections, encountered in the Orthopaedic service of an inner city hospital in UK.
  98. ncbi The impact of diabetes in patients with necrotizing soft tissue infections
    Lillian S Kao
    Department of General Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Surg Infect (Larchmt) 6:427-38. 2005
    Given the association of diabetes with necrotizing soft tissue infections (NSTIs) and hyperglycemia with mortality in critically ill patients, this study investigates the impact of diabetes and hyperglycemia in NSTI patients.
  99. pmc Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes
    Kishore Viswanathan
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, United States of America
    PLoS ONE 7:e29434. 2012
    Hospital- and community-acquired, complicated skin and soft tissue infections, often attributed to Staphylococcus aureus and Streptococcus pyogenes, present a significant health burden that is associated with increased health care costs ..
  100. ncbi Sepsis caused by peripelvic soft tissue infections in critically injured patients with multiple injuries and unstable pelvic fracture
    Yuichi Kataoka
    Kitasato University School of Medicine, Sagamihara, Japan
    J Trauma 66:1548-54; discussion 1554-5. 2009
    ..In critically injured patients with multiple injuries and unstable pelvic fracture, late mortality almost invariably results from sepsis...
  101. ncbi Delayed diagnosis of atypical mycobacterial skin and soft tissue infections in non-immunocompromized hosts
    Andrea Witteck
    Department of Infectious Diseases, Cantonal Hospital St Gallen, St Gallen, Switzerland
    Scand J Infect Dis 40:877-80. 2008
    Relapsing or persisting skin and soft tissue infections after injury with biological materials should prompt consideration of atypical mycobacteria, even in non-immunocompromized hosts...

Research Grants62

  1. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..an infection state commonly referred to as 'strep throat', but it is also implicated in skin and soft tissue infections, as well as life threatening invasive disease and the post-streptococcal autoimmune conditions of acute ..
  2. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..States: Staphylococcus aureus is the leading cause of bloodstream, lower respiratory tract, skin and soft tissue infections. The broad spectrum of clinically important staphylococcal diseases includes also endocarditis, septic ..
  3. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..RELEVANCE: Staphylococcus aureus is the leading cause of bloodstream, lower respiratory tract, skin and soft tissue infections in the United States with an annual mortality approaching 100,000 Americans lives...
  4. Prevention and therapy of Staphylococcus aureus infections
    Olaf Schneewind; Fiscal Year: 2010
    ..Staphylococcus aureus is the leading cause of bloodstream, lower respiratory tract, skin and soft tissue infections in the world...
  5. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    ..in disease Staphylococcus aureus is the leading cause of bloodstream, lower respiratory tract, skin and soft tissue infections in the United States. Demonstrating the broad tissue range and virulence properties of the pathogen, S...
  6. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..S. aureus is responsible for the vast majority of skin and soft tissue infections such as impetigo, folliculitis, and cellulitis. In addition, S...
  7. Multi-specific Antibody Therapy by targeting S. aureus toxins and polysaccharides
    M Javad Aman; Fiscal Year: 2013
    ..applicant): Staphylococcus aureus is a human pathogen that causes a wide range of diseases from skin and soft tissue infections (SSTI) to life threatening sepsis and pneumonia. Infections with S...
  8. The Role of SaeR/S During Staphylococcus aureus Skin Infections
    Jovanka M Voyich; Fiscal Year: 2012
    ..aureus pathogenesis in order to develop better methods to control/treat CA-MRSA disease and thus improve public health. ..
  9. A novel Structure Based Vaccine for staphylococcal alpha hemolysin
    Rajan P Adhikari; Fiscal Year: 2013
    ..aureus is a gram positive human pathogen that causes a wide range of infections ranging from skin and soft tissue infections to life threatening diseases like sepsis and pneumonia. S...
  10. Heroin Price, Purity and Outcomes Study
    Daniel H Ciccarone; Fiscal Year: 2013
    ..BTH is suggestively associated with soft tissue infections, while PH is ecologically correlated with HIV...
  11. Novel oxadiazols for the treatment of drug-resistant gram-positive bacteria
    Shahriar Mobashery; Fiscal Year: 2013
    ..by applicant): Staphylococcus aureus is responsible for a number of human diseases, including skin and soft tissue infections. Annually, 292,000 hospitalizations in the US are due to S...
  12. Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    Robert S Daum; Fiscal Year: 2013
    ..Double-Blind Trial of Clindamycin, Trimethoprim-Sulfamethoxazole, or Placebo for Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA)...
  13. Recurrent MRSA Infections: A Study of Risk Factors and Molecular Epidemiology
    MICHAEL ZDENEK DAVID; Fiscal Year: 2013
    ..of MRSA have arisen that are causing an epidemic of infections in the community, particularly skin and soft tissue infections but also less common severe, invasive infections...
  14. Engineering the immune response for improved resolution of Staphylococcus infecti
    SCOTT IRWIN SIMON; Fiscal Year: 2013
    ..For instance, MSRA involvement in skin and soft tissue infections increased from 4% to 42% between 2000 and 2005 and remains high...
  15. A longitudinal Study of CA-MRSA Nasal Colonization in College Sports Participants
    Clarence Buddy Creech; Fiscal Year: 2010
    ..aureus colonizes the anterior nares of nearly one-third of people and is the leading cause of skin and soft tissue infections in children and adults...
  16. Staphylococcus aureus resistance to topical antimicrobial agents in children
    JONATHON CHASE MCNEIL; Fiscal Year: 2013
    ..The data generated during this work can be used to fuel changes in clinical practice and improve outcomes for these vulnerable populations. ..
  17. A New Approach to Staphylococcus aureus Vaccine Development - Resubmission 01
    Brad J Spellberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Staphylococcus aureus is the most commonest cause of skin and soft tissue infections. Additionally, severe invasive S. aureus disease results in hospitalization with high mortality...
  18. MRSA Activation of Human Keratinocyte Signaling
    Alice S Prince; Fiscal Year: 2013
    ..aureus USA300 is a formidable human pathogen isolated from the majority of human skin and soft tissue infections in the US...
  19. EMERGEncy ID Net Study
    DAVID ANDREW TALAN; Fiscal Year: 2010
    ..the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among patients with skin and soft tissue infections. The specific aim for the EMERGEncy ID NET program is to continue collaboration with the CDC to conduct ..
  20. Exploratory Research on Late Initiation of Drug Injection
    Alexander H Kral; Fiscal Year: 2012
    ..Exploring DSS among late initiates will help to identify influential factors for the prevention of injection drug use, injection-related risks for HIV/AIDS, and other health and social consequences. ..
  21. Database designed novel anti-MRSA peptides
    Guangshun Wang; Fiscal Year: 2013
    ..aureus (MRSA) USA300 represents a clade of genetically related strains that are a major cause of skin and soft tissue infections in the hospital as well as the community settings in otherwise healthy individuals...
  22. Moving the Field Forward: Evaluation of Antibiotic Prescribing Practices, the Cli
    TIMOTHY CONRAD JENKINS; Fiscal Year: 2013
    ..research interests have focused on improving antibiotic use for the treatment of bloodstream and skin and soft tissue infections (SSTIs)...
  23. A Binary Probe-Based DNAzyme Cascade for Rapid Detection of MRSA/MSSA
    Xiaoli Su; Fiscal Year: 2012
    ..RELEVANCE: Staphylococcus aureus, particularly MRSA, is a major cause of infections ranging from skin and soft tissue infections to invasive, life-threatening infections such as bacteremia, endocarditis, etc...
  24. Clinical Trial for CA-MRSA Infections
    DENISE TRITT; Fiscal Year: 2011
    ..CA-MRSA) Infections program provides a clinically relevant treatment strategy for uncomplicated skin and soft tissue infections, more specifically, for treatment of suppurative infections (e.g...
  25. Structural, genetic, and functional analyses of the glycoproteins of Bacteroides
    LAURIE COMSTOCK; Fiscal Year: 2009
    ..abscesses and cases of anaerobic bacteremia, and has been isolated from patients with bone and soft tissue infections, and has been identified as a contributing factor to increased incidence of preterm labor...
  26. Bedside emergency ultrasound for the evaluation of soft tissue infections
    Jennifer Marin; Fiscal Year: 2009
    Between 2001-2003 there were 11.6 million annual ambulatory care visits for skin and soft tissue infections, with a 31% increase in emergency department visits compared to the previous decade, according to the National Hospital ..
  27. Clinical Trial for CA-MRSA Infections
    DENISE TRITT; Fiscal Year: 2013
    ..CA-MRSA) Infections program provides a clinically relevant treatment strategy for uncomplicated skin and soft tissue infections, more specifically, for treatment of suppurative infections (e.g...
  28. Clinical Trial for CA-MRSA Infections
    DENISE TRITT; Fiscal Year: 2012
    ..CA-MRSA) Infections program provides a clinically relevant treatment strategy for uncomplicated skin and soft tissue infections, more specifically, for treatment of suppurative infections (e.g...
  29. Drug Market Characteristics: Antecedents and Sequelae on the U.S. Mexico Border
    Steffanie Strathdee; Fiscal Year: 2009
    ..g., soft tissue infections, overdose, mortality) among IDUs in both cities;3) To study trends in bi-directional cross-border mobility ..
  30. STAPHYLOCOCCUS AUREUS FIBRONECTIN-BINDING ADHESINS
    Barbara Menzies; Fiscal Year: 2003
    ..The use of FnBP as an anti-adhesin presents a novel therapeutic tool for the prevention of S. aureus infections. ..
  31. ANTIBIOTIC RESISTANCE IN ORAL & COLONIC ANAEROBES
    FRANCIS MACRINA; Fiscal Year: 1992
    ..This work will use a wide array of modern genetic methodology including mutant isolation, transmission genetics, molecular cloning, in situ filter blot hybridization and DNA base sequence analysis...
  32. ABC TRANSPORTER IN GROUP A STREPTOCOCCUS
    CAMERON ASHBAUGH; Fiscal Year: 1999
    ..The spectrum of GAS disease includes pharyngitis, skin infections, life-threatening soft tissue infections, and the unique postinfectious complications of acute rheumatic fever and glomerulonephritis...
  33. Antibiotics from Soil DNA Clone Libraries: Selection of Anti-MRSA Lead Compounds
    Ena Urbach; Fiscal Year: 2007
    ..Infection with S. aureus is a leading cause of sepsis and bacteremia, as well as pulmonary, skin and soft tissue infections, in both hospital and community settings. The rise of multiply drug-resistant pathogens generally, and S...
  34. Role of Pet Animals as Reservoirs for MRSA in Households
    Daniel Morris; Fiscal Year: 2009
    ..to circulate either in the community or within healthcare facilities, and which cause serious skin and soft tissue infections of people...
  35. P GINGIVALIS HSP90 RECOGNITION IN PERIODONTAL DISEASE
    Domenica Sweier; Fiscal Year: 2003
    ..Heat shock proteins have been found to be important in many soft tissue infections and have been referred to as virulence factors in some models...
  36. PREVENTION OF INFECTIOUS DISEASE IN INJECTION DRUG USERS
    CARMEN MASSON; Fiscal Year: 2003
    ..drug users are at high risk for human immunodeficiency virus (HIV) infection, hepatitis B and C, skin and soft tissue infections, and other infectious diseases...
  37. Hospital Care IDUs with Soft Tissue Infections
    Traci Takahashi; Fiscal Year: 2004
    ..The aims of the proposed study are to (1) describe hospitalizations for illicit drug users with soft tissue infections (as a proxy for injection drug use-related soft tissue infections), (2) provide the first national ..
  38. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  39. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  40. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  41. Antiretviral therapy adherence in resource poor setting
    David Bangsberg; Fiscal Year: 2003
    ..This will be a first and necessary step to identifying the distribution and predictors of adherence to HIV antiretroviral therapy in a resource poor setting. ..
  42. Early Diagnosis of Growth Disorders Uing MR Imaging
    Diego Jaramillo; Fiscal Year: 2004
    ....
  43. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  44. Genital Ulcer Disease and HIV Transmission
    Jeanne Sheffield; Fiscal Year: 2005
    ..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
  45. CARDIOTOXICITY OF STREPTOCOCCAL PYROGENIC EXOTOXINS
    Patrick Schlievert; Fiscal Year: 2006
    ....
  46. MECHANISMS OF GLYCOPEPTIDE RESISTANCE IN STAPHYLOCOCCI
    Robert Daum; Fiscal Year: 2006
    ..These studies should lead to an understanding of the mechanisms by which S. aureus resist the bactericidal effect of GPs and hopefully can identify new ideas regarding therapy of infections caused by resistant isolates. ..
  47. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. HIV Outcomes Research and Training in Uganda
    David Bangsberg; Fiscal Year: 2008
    ..abstract_text> ..
  49. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  50. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  51. Sialic Acid O-Acetylation in GBS Pathogenesis & Immunity
    Victor Nizet; Fiscal Year: 2010
    ..Companion analyses will be performed on GBS isolates and human sera from recent prospective seroepidemiologic studies. ..
  52. A RCT of HIV Adherence Case Management and Modified DOT
    Margot Kushel; Fiscal Year: 2007
    ..Outcomes will be assessed quarterly during the 6-month intervention and during a 6 month post-intervention period to examine the durability of the intervention effect. ..
  53. Spread of Community-Acquired MRSA Among Household Contacts
    Robert S Daum; Fiscal Year: 2010
    ..Outbreaks of skin and soft tissue infections, necrotizing pneumonia, and sepsis syndromes due to CA-MRSA have been reported with increasing frequency...
  54. A Genetic Approach to Virulence in C. albicans
    Suzanne Noble; Fiscal Year: 2007
    ..Results from this work should enhance our understanding of fungal pathogenesis and identify novel targets for antifungal therapy. [unreadable] [unreadable]..
  55. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  56. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. SLS: Molecular Basis and Role in Invasive GAS Disease
    Victor Nizet; Fiscal Year: 2006
    ..These hypotheses will be tested by molecular genetic studies, attempts protein purification and antibody development, and the use of targeted SLS mutants in in vitro assays of phagocytic function and our in vivo mouse model of GAS NF. ..
  58. MRSA Colonization and Control in the Cook County Jail - R01
    Robert Daum; Fiscal Year: 2008
    ..We hope that the Cook County jail will become a model jail for the control of MRSA and other resistant bacteria. [unreadable] [unreadable] [unreadable]..
  59. IL-1 and IL-1ra Stimulation of S aureus Replication
    SIVADASAN KANANGAT; Fiscal Year: 2003
    ..A better understanding of how bacteria such as S. aureus use IL-1 family of cytokines to replicate and defeat the host defense is highly relevant to the study of septic arthritis. ..
  60. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
  61. Impact of Gender on Infected Hospitalized Patients
    Robert Sawyer; Fiscal Year: 2006
    ..Data obtained from this research will be used to design interventional studies utilizing hormonal manipulation, i. e., replacement or blockade, to improve outcomes from otherwise lethal infectious diseases. ..