septic shock

Summary

Summary: Shock due to circulatory insufficiency caused most commonly by gram-negative BACTEREMIA. It is less often the result of the persistent presence of other micro-organisms in the blood (FUNGEMIA; VIREMIA); in rare instances, it is caused by gram-positive organisms, but with different symptomatology.

Top Publications

  1. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
  2. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
  3. ncbi Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Crit Care Med 34:1589-96. 2006
  4. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  5. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
  6. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
  7. ncbi TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    A Bouchon
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Nature 410:1103-7. 2001
  8. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
  9. ncbi Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Chest 136:1237-48. 2009
  10. ncbi Time- and fluid-sensitive resuscitation for hemodynamic support of children in septic shock: barriers to the implementation of the American College of Critical Care Medicine/Pediatric Advanced Life Support Guidelines in a pediatric intensive care unit in
    Cláudio F Oliveira
    Department of Pediatrics, Faculdade de Medicina, Pediatric Intensive Care Unit, Instituto da Criança Pedro de Alcântra, Universidade de Sao Paulo, Sao Paulo, Brazil
    Pediatr Emerg Care 24:810-5. 2008

Detail Information

Publications372 found, 100 shown here

  1. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
    To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock.
  2. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  3. ncbi Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Crit Care Med 34:1589-96. 2006
    To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock.
  4. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004.
  5. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand...
  6. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
    To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004.
  7. ncbi TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    A Bouchon
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Nature 410:1103-7. 2001
    ..Excessive inflammation owing to bacterial infections can lead to tissue damage and septic shock. Here we show that inflammatory responses to microbial products are amplified by a pathway mediated by ..
  8. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  9. ncbi Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Chest 136:1237-48. 2009
    Our goal was to determine the impact of the initiation of inappropriate antimicrobial therapy on survival to hospital discharge of patients with septic shock.
  10. ncbi Time- and fluid-sensitive resuscitation for hemodynamic support of children in septic shock: barriers to the implementation of the American College of Critical Care Medicine/Pediatric Advanced Life Support Guidelines in a pediatric intensive care unit in
    Cláudio F Oliveira
    Department of Pediatrics, Faculdade de Medicina, Pediatric Intensive Care Unit, Instituto da Criança Pedro de Alcântra, Universidade de Sao Paulo, Sao Paulo, Brazil
    Pediatr Emerg Care 24:810-5. 2008
    To analyze mortality rates of children with severe sepsis and septic shock in relation to time-sensitive fluid resuscitation and treatments received and to define barriers to the implementation of the American College of Critical Care ..
  11. ncbi Current epidemiology of septic shock: the CUB-Réa Network
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Université de Versaille Saint Quentinen Yvelinnes, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Am J Respir Crit Care Med 168:165-72. 2003
    To update the epidemiology of septic shock we analyzed clinical, microbiologic, and outcome variables from 100,554 intensive care unit admissions on the Collège des Utilisateurs de Bases de données en Réanimation (CUB-Réa) database, ..
  12. ncbi NF-kappa B activation as a pathological mechanism of septic shock and inflammation
    Shu Fang Liu
    Div of Pulmonary and Critical Care Medicine, Long Island Jewish Medical Center, RM B371, New Hyde Park, NY 11040, USA
    Am J Physiol Lung Cell Mol Physiol 290:L622-L645. 2006
    The pathophysiology of sepsis and septic shock involves complex cytokine and inflammatory mediator networks. NF-kappaB activation is a central event leading to the activation of these networks...
  13. ncbi Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department
    David F Gaieski
    Department of Emergency Medicine, Division of Pulmonary, Allergy, and Critical Care, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 38:1045-53. 2010
    To study the association between time to antibiotic administration and survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department.
  14. ncbi Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
    Guillaume Monneret
    Immunology Laboratory, Hopital Neurologique, Lyon, France
    Intensive Care Med 32:1175-83. 2006
    The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression...
  15. ncbi Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study
    Alvaro Castellanos-Ortega
    Intensive Care Medicine Department, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Crit Care Med 38:1036-43. 2010
    To describe the effectiveness of the Surviving Sepsis Campaign bundles with regard to both implementation and outcome in patients with septic shock and to determine the contribution of the various elements of the bundles to the outcome.
  16. ncbi Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
    Experimental and clinical studies of septic shock support the concept that early resuscitation with fluid and inotropic therapies improves survival in a time-dependent manner...
  17. ncbi Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock
    S M Opal
    Infectious Disease Division, Brown University School of Medicine and Memorial Hospital of Rhode Island, Providence, Rhode Island 02860, USA
    J Infect Dis 180:1584-9. 1999
    ..protein (LBP) levels were measured in a group of 253 patients at the onset of severe sepsis and/or septic shock. Endotoxin levels were significantly greater than control levels (n=33; mean +/- SD, 5.1+/-7.3 pg/mL) in 78...
  18. pmc Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum
    Hector R Wong
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 37:1558-66. 2009
    To advance our biological understanding of pediatric septic shock, we measured the genome-level expression profiles of critically ill children representing the systemic inflammatory response syndrome (SIRS), sepsis, and septic shock ..
  19. ncbi Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial
    Dinna N Cruz
    Department of Nephrology, Dialysis, and Transplantation, St Bortolo Hospital and International Renal Research Institute Vicenza, 36100 Vicenza, Italy
    JAMA 301:2445-52. 2009
    ..Gram-negative-induced abdominal sepsis is likely associated with high circulating endotoxin. Reducing circulating endotoxin levels with polymyxin B hemoperfusion could potentially improve patient clinical outcomes...
  20. ncbi Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
    To study early microcirculatory perfusion indices in patients with severe sepsis/septic shock, compare early microcirculatory indices in sepsis survivors versus nonsurvivors, and identify systemic hemodynamic/oxygen transport variables ..
  21. pmc Brazilian Sepsis Epidemiological Study (BASES study)
    Eliezer Silva
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Crit Care 8:R251-60. 2004
    ..This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome..
  22. ncbi TREM-1 promotes survival during septic shock in mice
    Sebastien Gibot
    Réanimation Médicale, Hopital Central, Nancy, France
    Eur J Immunol 37:456-66. 2007
    Triggering receptor expressed on myeloid (TREM)-1 is integral to the inflammatory response occurring during septic shock, although its precise function has yet to be determined...
  23. ncbi Circulating microparticles from patients with septic shock exert protective role in vascular function
    Hadj Ahmed Mostefai
    INSERM U771, CNRS UMR 6214, and Université d Angers, France
    Am J Respir Crit Care Med 178:1148-55. 2008
    ..Sepsis is an archetypal condition with molecular links between inflammation and coagulation. Both events can be orchestrated by the interaction between circulating and vascular cells that under activation release microparticles...
  24. ncbi A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic/meta-regression study
    Anand Kumar
    Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1651-64. 2010
    To assess whether a potential benefit with combination antibiotic therapy is restricted to the most critically ill subset of patients, particularly those with septic shock.
  25. ncbi Cutting edge: bacterial lipoprotein induces endotoxin-independent tolerance to septic shock
    Jiang Huai Wang
    Department of Academic Surgery, National University of Ireland, Cork University Hospital, Cork, Ireland
    J Immunol 170:14-8. 2003
    ..These results indicate that BLP tolerance is a novel adaptive host response associated with a unique protective effect during septic shock.
  26. ncbi Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    J D MacMicking
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, New York 10021, USA
    Cell 81:641-50. 1995
    ..Thus, there exist both iNOS-dependent and iNOS-independent routes to LPS-induced hypotension and death...
  27. ncbi Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial
    B L Warren
    Brown University School of Medicine, Infectious Disease Division, Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02860, USA
    JAMA 286:1869-78. 2001
    ..system and depletion of endogenous anticoagulants are frequently found in patients with severe sepsis and septic shock. Diffuse microthrombus formation may induce organ dysfunction and lead to excess mortality in septic shock...
  28. ncbi Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
    Jonas Sunden-Cullberg
    Department of Medicine, Center for Infectious Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Crit Care Med 33:564-73. 2005
    ..group box-1 protein (HMGB1) in relation to clinical features in a population of patients with severe sepsis or septic shock and to compare these with the kinetics of the cytokines interleukin-6, interleukin-8, interleukin-10, and tumor ..
  29. ncbi The cardiovascular response of normal humans to the administration of endotoxin
    A F Suffredini
    Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892
    N Engl J Med 321:280-7. 1989
    Marked abnormalities in cardiovascular function accompany septic shock, and bacterial endotoxin is believed to be one of the principal mediators of these abnormalities...
  30. pmc Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients
    Fabienne Venet
    Division of Surgical Research, Rhode Island Hospital, Brown University, Providence, RI, USA
    Intensive Care Med 35:678-86. 2009
    ..We investigated whether CD4(+)CD25(+) regulatory T cells (Treg) participate in the induction of lymphocyte anergy after sepsis...
  31. pmc Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock
    Edwin S Van Amersfoort
    Division of Biopharmaceutics, Leiden Amsterdam Center of Drug Research, Leiden University, Leiden, The Netherlands
    Clin Microbiol Rev 16:379-414. 2003
    Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators as a consequence of the interaction of the immune system with bacteria and bacterial wall constituents in the body...
  32. ncbi Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shock
    M Feissel
    , Centre Hospitalier, Belfort, France
    Chest 119:867-73. 2001
    ..PATIENTS: Nineteen sedated septic shock patients who were receiving mechanical ventilation and who had preserved left ventricular (LV) systolic ..
  33. ncbi Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada
    Intensive Care Med 35:871-81. 2009
    To describe the incidence and outcomes associated with early acute kidney injury (AKI) in septic shock and explore the association between duration from hypotension onset to effective antimicrobial therapy and AKI.
  34. ncbi Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Crit Care Med 32:858-73. 2004
    ..experts representing 11 international organizations developed management guidelines for severe sepsis and septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, ..
  35. ncbi Pneumococcal pneumonia presenting with septic shock: host- and pathogen-related factors and outcomes
    C Garcia-Vidal
    Infectious Disease Department, Hospital Universitari de Bellvitge, Feixa Llarga s n, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Thorax 65:77-81. 2010
    Host- and pathogen-related factors associated with septic shock in pneumococcal pneumonia are not well defined. The aim of this study was to identify risk factors for septic shock and to ascertain patient outcomes...
  36. ncbi LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock
    A Mignon
    INSERM U 129 ICGM INSERM U 380 ICGM Service d Anatomopathologie, Hopital du Kremlin Bicêtre INSERM U 294, Faculte Xavier Bichat, Paris, France
    Am J Respir Crit Care Med 159:1308-15. 1999
    ..with D-galactosamine, have largely contributed to the basic rationale for innovative clinical trials in human septic shock, which have, to date, failed. The ability of these models to reproduce human disease has been highly discussed...
  37. ncbi M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage
    Heiko Herwald
    Department of Cell and Molecular Biology, Lund University, Tornavagen 10, S 221 84 Lund, Sweden
    Cell 116:367-79. 2004
    ..In addition, M protein/fibrinogen complexes were identified in tissue biopsies from a patient with necrotizing fasciitis and STSS, further underlining the pathogenic significance of such complexes in severe streptococcal infections...
  38. ncbi C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia
    G Hillas
    Dept of Respiratory and Critical Care Medicine, SOTIRIA Chest Diseases Hospital, Athens, Greece
    Eur Respir J 35:805-11. 2010
    ..protein (CRP) threshold values and kinetics as predictors of ventilator-associated pneumonia (VAP) survival and septic shock development. 45 adult patients with VAP were studied...
  39. pmc Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock
    Thomas P Shanley
    C S Mott Children s Hospital at the University of Michigan, Ann Arbor, Michigan, USA
    Mol Med 13:495-508. 2007
    ..studies focused on the expression profiles of signaling pathways and gene networks in children with septic shock. Genome-level expression profiles were generated from whole blood-derived RNA of children with septic shock (n=..
  40. ncbi ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation
    Cláudio F de Oliveira
    Paediatric Intensive Care Unit, Department of Paediatrics, Instituto da Criança Pedro de Alcântra, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Intensive Care Med 34:1065-75. 2008
    The ACCM/PALS guidelines address early correction of paediatric septic shock using conventional measures...
  41. ncbi Cardiac dysfunction in severe sepsis and septic shock
    Sergio L Zanotti-Cavazzoni
    Division of Critical Care Medicine, Cooper University Hospital, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08103, USA
    Curr Opin Crit Care 15:392-7. 2009
    Severe sepsis and septic shock are among the most important causes of morbidity and mortality in patients admitted to the intensive care unit...
  42. ncbi Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    Eva Lorenz
    Pulmonary and Critical Care Medicine, Duke University Medical Center, Research Drive, Room 275 MSRB, DUMC Box 2629, Durham, NC 27710, USA
    Arch Intern Med 162:1028-32. 2002
    b>Septic shock remains a significant health concern worldwide, and despite progress in understanding the physiological and molecular basis of septic shock, the high mortality rate of patients with septic shock remains unchanged...
  43. ncbi Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality
    Tommaso Mauri
    Dipartimento di Medicina Perioperatoria e Terapie Intensive, Azienda Ospedaliera San Gerardo di Monza, Via Pergolesi 33, 20052, Monza, Italy
    Intensive Care Med 36:621-9. 2010
    ..During sepsis a massive inflammatory activation and coagulation/fibrinolysis dysfunction occur. PTX3, as a mediator of inflammation, may represent an early marker of severity and outcome in sepsis...
  44. ncbi Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock
    Katri Saukkonen
    Departments of Medicine and Emergency Care, Helsinki University Central Hospital, Helsinki, Finland
    Clin Chem 54:1000-7. 2008
    ..We investigated the value of plasma DNA for the prediction of intensive care unit (ICU) and hospital mortality and its association with the degree of organ dysfunction and disease severity in patients with severe sepsis...
  45. ncbi Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1773-85. 2010
    b>Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibility that combination antibiotic therapy of bacterial septic shock improves outcome is controversial...
  46. pmc Identification of pediatric septic shock subclasses based on genome-wide expression profiling
    Hector R Wong
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Med 7:34. 2009
    b>Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses...
  47. ncbi Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock
    Marc Moss
    Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA 30335, USA
    Crit Care Med 31:869-77. 2003
    ..The goal of this study was to determine the effects of chronic alcohol abuse on the incidence and severity of the acute respiratory distress syndrome and multiple organ dysfunction syndrome in patients with septic shock.
  48. pmc Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial
    Martin W Dunser
    Department of Intensive Care Medicine, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland
    Crit Care 13:R181. 2009
    It is unclear to which level mean arterial blood pressure (MAP) should be increased during septic shock in order to improve outcome...
  49. ncbi Acute renal failure and sepsis
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 351:159-69. 2004
  50. ncbi Elevated serum levels of S-100beta protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock
    Duc Nam Nguyen
    Critical Care Department, Vrije Universiteit Brussel, Brussels, Belgium
    Crit Care Med 34:1967-74. 2006
    We investigated whether serum levels of neuron-specific enolase (NSE) and S-100beta protein could be used to evaluate cerebral injury and to predict outcome in severe sepsis and severe septic shock.
  51. ncbi N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients
    A R Heller
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Dresden, Germany
    Crit Care Med 29:272-6. 2001
    ..To evaluate whether NAC affects host defense mechanisms in critically ill patients, thus predisposing to increased risk of infection, the current study focuses on neutrophil phagocytotic and burst activity after treatment with NAC...
  52. ncbi Beneficial effects of the heme oxygenase-1/carbon monoxide system in patients with severe sepsis/septic shock
    Shoji Takaki
    Department of Emergency and Critical Care Medicine, Aichi Medical University, Nagakute cho, Aichi, Japan
    Intensive Care Med 36:42-8. 2010
    ..relations among the arterial carbon monoxide (CO) concentration, heme oxygenase (HO)-1 expression by monocytes, oxidative stress, plasma levels of cytokines and bilirubin, and the outcome of patients with severe sepsis or septic shock.
  53. ncbi Circulating endothelial cells in patients with septic shock
    M Mutunga
    Department of Anaesthesia and Intensive Care Medicine, Newcastle-upon-Tyne National Health Service Trust, Newcastle-upon-Tyne, United Kingdom
    Am J Respir Crit Care Med 163:195-200. 2001
    ..role in the control of microvascular tone, and it has been proposed that vascular endothelial damage occurs in septic shock, producing multiorgan failure...
  54. ncbi Early intravenous unfractionated heparin and mortality in septic shock
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 36:2973-9. 2008
    Sepsis and septic shock represent a systemic inflammatory state with substantial pro-coagulant elements. Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties...
  55. ncbi Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Paris, France
    Hepatology 36:1070-8. 2002
    In cirrhosis, lipopolysaccharide (LPS, a product of Gram-negative bacteria) in the blood may cause septic shock. LPS-elicited induction of arterial inducible nitric oxide synthase (iNOS) results in nitric oxide (NO)-induced vasodilation, ..
  56. ncbi Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats
    Jeng Yuan Wu
    Division of Thoracic Surgery, Taichung Tzu Chi General Hospital, Taichung, Taiwan
    J Pineal Res 45:106-16. 2008
    The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood...
  57. ncbi Oxidative stress in septic shock and disseminated intravascular coagulation
    Daniela Salvemini
    MetaPhore Pharmaceuticals, St Louis, MO 63114, USA
    Free Radic Biol Med 33:1173-85. 2002
    ..A considerable body of recent evidence suggests that oxidant stress plays a major role in several aspects of septic shock and disseminated intravascular coagulation (DIC), and it is the subject of this review...
  58. ncbi Invasive group A streptococcal infections: T1M1 isolates expressing pyrogenic exotoxins A and B in combination with selective lack of toxin-neutralizing antibodies are associated with increased risk of streptococcal toxic shock syndrome
    B K Eriksson
    Division of Infectious Diseases, Department of Immunology, Karolinska Institute, Huddinge University Hospital, Sweden
    J Infect Dis 180:410-8. 1999
    ..Neutralization of SpeB was significantly lower in sera of patients with STSS than in sera from persons with bacteremia or erysipelas...
  59. ncbi Thymosin beta(4) reduces lethality and down-regulates inflammatory mediators in endotoxin-induced septic shock
    Mahnaz Badamchian
    Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 Eye Street, N W, Washington, DC 20037, USA
    Int Immunopharmacol 3:1225-33. 2003
    ..05). Given the recognized role of proinflammatory cytokines in septic shock and of extracellular F- and G-actin in the pathophysiology of multiple organ dysfunction, we have investigated ..
  60. ncbi Methylene blue for the treatment of septic shock
    Christopher A Paciullo
    Department of Pharmaceutical Services, Emory University Hospital, Atlanta, Georgia 30322, USA
    Pharmacotherapy 30:702-15. 2010
    b>Septic shock is a major cause of morbidity and mortality in the intensive care unit, and effective therapies are limited...
  61. ncbi Early mortality in patients with community-acquired pneumonia: causes and risk factors
    C Garcia-Vidal
    Infectious Disease Service, Hospital University of Bellvitge, Feixa Llarga s n 08907 L Hospitalet, Barcelona, Spain
    Eur Respir J 32:733-9. 2008
    ..Overall mortality was 7.7%. The main causes of early mortality were respiratory failure and septic shock/multiorgan failure...
  62. ncbi Endotoxin as a therapeutic target in septic shock
    C C Corriveau
    Critical Care Department, Children s National Medical Center, Washington, D C
    Infect Agents Dis 2:35-43. 1993
    Endotoxin initiates a broad inflammatory response in mammals that has many similarities to de novo septic shock in patients...
  63. pmc Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock
    Hiroki Sekine
    The Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Mol Cell Biol 29:6391-400. 2009
    ..Here, we demonstrate that AhR knockout (AhR KO) mice are hypersensitive to lipopolysaccharide (LPS)-induced septic shock, mainly due to the dysfunction of their macrophages...
  64. pmc Epidemiology of sepsis in Norway in 1999
    Hans Flaatten
    Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen Norway
    Crit Care 8:R180-4. 2004
    ..Little is known about the occurrence of sepsis in general hospital populations. The goal of the present study was to reveal the epidemiology of sepsis in Norwegian hospitals over 1 year...
  65. ncbi Extracellular hsp70 levels in children with septic shock
    Derek S Wheeler
    Department of Pediatrics, University of Cincinnati College of Medicine and Children s Hospital Research Foundation, Cincinnati, OH, USA
    Pediatr Crit Care Med 6:308-11. 2005
    To determine whether hsp70 is elevated in the plasma of children with septic shock.
  66. ncbi Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock
    Dian liang Zhang
    Department of General Surgery, Affiliated Hospital, Qingdao University Medial College, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 11:4409-13. 2005
    To investigate IL-1beta+3 594 in the 5th intron, IL-10-1 082 and CD14-159 polymorphisms in patients with acute pancreatitis (AP) and septic shock.
  67. ncbi Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations
    G W Waterer
    Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Australia
    Am J Respir Crit Care Med 163:1599-604. 2001
    ..b>Septic shock (SS) was defined using American College of Chest Physicians/Society of Critical Care Medicine (ACCP-SCCM) ..
  68. ncbi Prognostic factors of mortality in patients with community-acquired bloodstream infection with severe sepsis and septic shock
    Arturo Artero
    Department of Internal Medicine, Hospital Universitario Dr Peset Av Gaspar Aguilar 90, 46017 Valencia, Spain
    J Crit Care 25:276-81. 2010
    The purpose of the study was to determine the independent risk factors on mortality in patients with community-acquired severe sepsis and septic shock.
  69. ncbi Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain
    Ricard Ferrer
    Centro de Críticos, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Instituto Universitario Parc Tauli, Universidad Autonoma de Barcelona, Barcelona, Spain
    JAMA 299:2294-303. 2008
    Concern exists that current guidelines for care of patients with severe sepsis and septic shock are followed variably, possibly due to a lack of adequate education.
  70. ncbi Chronic morphine accelerates the progression of lipopolysaccharide-induced sepsis to septic shock
    Frank M Ocasio
    Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
    J Neuroimmunol 149:90-100. 2004
    ..Our study presents both the molecular and cellular mechanisms underlying the potentiated LPS-induced inflammation and accelerated progression to septic shock seen with chronic morphine exposure.
  71. ncbi Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum
    Enrico Lupia
    Department of Clinical Pathophysiology, University of Turin, Italy
    Basic Res Cardiol 105:609-20. 2010
    ..We finally studied the role of TPO in the negative inotropic effect exerted by human septic shock (HSS) serum and TPO cooperation with TNF-alpha and IL-1beta...
  72. ncbi Septic shock
    Djillali Annane
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Lancet 365:63-78. 2005
    b>Septic shock, the most severe complication of sepsis, is a deadly disease. In recent years, exciting advances have been made in the understanding of its pathophysiology and treatment...
  73. ncbi Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endothelium in Escherichia coli endotoxin-induced shock
    Q Pu
    Department of Pharmacology, Lille University Hospital, 59037 Lille Cedex, France
    Crit Care Med 29:1181-8. 2001
    ....
  74. pmc The relationship between CD4+CD25+CD127- regulatory T cells and inflammatory response and outcome during shock states
    François Hein
    Service de Reanimation Medicale, Hopital Central, CHU de Nancy, 29 Bld du Mal de Lattre de Tassigny, Nancy, 54000, France
    Crit Care 14:R19. 2010
    ....
  75. ncbi Mediator modulation therapy of severe sepsis and septic shock: does it work?
    R Phillip Dellinger
    Crit Care Med 32:282-6. 2004
  76. ncbi Effect of ghrelin on septic shock in rats
    Lin Chang
    Cardiovascular Research Institute, The First Hospital of Peking University, Beijing 100034, China
    Acta Pharmacol Sin 24:45-9. 2003
    To study the role of ghrelin in the late stage of septic shock in rats.
  77. ncbi Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
    A Haziot
    Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA
    Immunity 4:407-14. 1996
    ..Surprisingly, CD14-deficient mice also showed dramatically reduced levels of bacteremia, suggesting an unexpected role for CD14 in the dissemination of Gram-negative bacteria...
  78. ncbi Ebola hemorrhagic fever and septic shock
    Mike Bray
    J Infect Dis 188:1613-7. 2003
  79. ncbi C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunction
    Christoph Caliezi
    Central Laboratory of Hematology, University Hospital, Inselspital, Bern, Switzerland
    Crit Care Med 30:1722-8. 2002
    To investigate the efficacy and the safety of the parenteral administration of C1-inhibitor to patients with severe sepsis or septic shock.
  80. ncbi Multiple organ failure in patients with cardiogenic shock is associated with high plasma levels of interleukin-6
    Alexander Geppert
    Department of Cardiology, Intensive Care Unit, University of Vienna, Austria
    Crit Care Med 30:1987-94. 2002
    In patients with septic shock, multiple organ failure (MOF) is associated with high levels of interleukin-6 (IL-6)...
  81. pmc Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
    Stephen Trzeciak
    Department of Medicine, Divisions of Cardiovascular Disease and Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza D363, Camden, NJ 08103, USA
    Intensive Care Med 34:2210-7. 2008
    ..We hypothesized that changes in microcirculatory flow during resuscitation are associated with changes in organ failure over the first 24 h of sepsis therapy...
  82. ncbi Renal failure in septic shock: predictive value of Doppler-based renal arterial resistive index
    Nicolas Lerolle
    Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service de Reanimation Medicale, 20, rue Leblanc, 75908 Paris Cedex 15, France
    Intensive Care Med 32:1553-9. 2006
    Because acute renal failure (ARF) is frequent in septic shock, an early marker of ARF could impact on management of such patients. High renal arterial resistive index (RI) is associated with parenchymatous renal failure...
  83. ncbi Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study
    Marco Confalonieri
    Azienda Ospedaliero Universitaria di Trieste, Strada di Fiume 447, 34100 Trieste, Italy
    Am J Respir Crit Care Med 171:242-8. 2005
    ..from study entry) and multiple organ dysfunction syndrome (MODS) score by Study Day 8 and reduction in delayed septic shock. Forty-six patients entered the study...
  84. ncbi Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock
    Christophe Clec'h
    Medico Surgical Intensive Care Unit, Avicenne Teaching Hospital, Bobigny, France
    Crit Care Med 34:102-7. 2006
    To assess whether different diagnostic and prognostic cutoff values of procalcitonin should be considered in surgical and in medical patients with septic shock.
  85. pmc Bundled care for septic shock: an analysis of clinical trials
    Amisha V Barochia
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 38:668-78. 2010
    ..Valid bundles require effective components with additive benefits. Proponents encourage evaluation of bundles, both as a whole and based on the performance of each component...
  86. pmc Leukocyte subset-derived genomewide expression profiles in pediatric septic shock
    Hector R Wong
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 11:349-55. 2010
    ..To directly assess whether genomewide expression profiles derived from leukocyte subsets are comparable to that of whole blood as measured by enrichment for genes corresponding to metabolic and signaling pathways...
  87. ncbi Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock
    Jonas Sunden-Cullberg
    Department of Medicine, Division of Infectious Diseases, Center for Infectious Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden
    Crit Care Med 35:1536-42. 2007
    Resistin induces insulin resistance in mice. In humans, recent data suggest that resistin functions as a proinflammatory cytokine. Here, we studied resistin up to 2 wks after admission in patients with septic shock and/or severe sepsis.
  88. pmc Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock--does the dose matter?
    Federico Pea
    Department of Experimental and Clinical Pathology, Institute of Clinical Pharmacology and Toxicology, Medical School, University of Udine, 33100 Udine, Italy
    Crit Care 13:214. 2009
    Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean prompt achievement and maintenance of optimal exposure at the infection site with broad-spectrum antimicrobial agents administered in a timely ..
  89. ncbi Cardiovascular management of septic shock
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
    Crit Care Med 31:946-55. 2003
  90. ncbi Occult hypoperfusion and mortality in patients with suspected infection
    Michael D Howell
    Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Medicine, KB 23, 330 Brookline Avenue, Boston, MA 02215, USA
    Intensive Care Med 33:1892-9. 2007
    ..To determine, in the early stages of suspected clinically significant infection, the independent relationship of the presenting venous lactate level to 28-day in-hospital mortality...
  91. ncbi MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
    J Bernhagen
    Picower Institute for Medical Research, Manhasset, New York 11030
    Nature 365:756-9. 1993
    Cytokines are critical in the often fatal cascade of events that cause septic shock. One regulatory system that is likely to be important in controlling inflammatory responses is the neuroendocrine axis...
  92. ncbi Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock
    Nazima Pathan
    Department of Paediatrics, Imperial College of Science, Technology and Medicine, W2 1PG, London, UK
    Lancet 363:203-9. 2004
    Myocardial failure has a central role in the complex pathophysiology of septic shock and contributes to organ failure and death...
  93. ncbi High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications
    Aihua Wu
    Department of Anaesthesia, Beijing Hospital, Beijing 100730, PR China
    Shock 21:210-21. 2004
    Sepsis and septic shock are important causes of morbidity and lethality in noncoronary intensive care units...
  94. ncbi Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Section of Critical Care Medicine, Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden, NJ 08103, USA
    Intensive Care Med 30:536-55. 2004
    To develop management guidelines for severe sepsis and septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase awareness and improve ..
  95. ncbi Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock
    Shih Hua Fang
    Department of Microbiology, School of Medicine, China Medical University, Taichung 404, Taiwan
    Life Sci 74:743-56. 2003
    ..findings indicated that morin may exhibit anti-inflammatory activity and reduced the incidence of experimental septic shock through decreasing the functions of macrophages and may regulate immune response through modulating the ..
  96. ncbi Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial
    Rolf Busund
    Department of Cardiothoracic and Vascular Surgery, Tromsø University Hospital, 9038 Tromsø, Norway
    Intensive Care Med 28:1434-9. 2002
    To determine the therapeutic efficacy and safety of plasmapheresis in the treatment of patients with severe sepsis and septic shock.
  97. pmc Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence
    Stephen B Beres
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 99:10078-83. 2002
    ..Taken together, the results show that phage-mediated recombination has played a critical role in the emergence of a new, unusually virulent clone of serotype M3 GAS...
  98. ncbi Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization
    Frederic Chagnon
    Groupe de Recherche en Physiopathologie Respiratoire, Centre de Recherche Clinique, Universite de Sherbrooke, PQ, Canada
    Circ Res 96:1095-102. 2005
    ..inhibitory factor (MIF) has recently been identified as a cardiac-derived myocardial depressant factor in septic shock. Putative mechanisms by which MIF affects cardiac function are unknown...
  99. ncbi Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent
    Gloria Garcia-Segarra
    Medical Intensive Care Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    Intensive Care Med 33:1354-62. 2007
    ..To evaluate the effect of the 4G/5G PAI-1 gene polymorphism on the development of organ failure and outcome in critically ill patients with septic syndromes...
  100. ncbi Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes
    I Dimopoulou
    2nd Department of Critical Care Medicine, University of Athens, Greece
    Inflamm Res 58:127-32. 2009
    ..To describe the concentrations of sTREM-1 in patients with sepsis and to explore the effects of their serum on the expression of TREM-1 on U937 monocytes...
  101. ncbi The importance of fluid management in acute lung injury secondary to septic shock
    Claire V Murphy
    Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO, USA
    Chest 136:102-9. 2009
    Recent studies have suggested that early goal-directed resuscitation of patients with septic shock and conservative fluid management of patients with acute lung injury (ALI) can improve outcomes...

Research Grants77

  1. Effects of Vasoactive Drugs on Perfusion in Septic Shock
    Patrick Murray; Fiscal Year: 2005
    ..the regional and systemic effects of traditional and novel vasoactive drugs in critically ill patients with septic shock. Sepsis. the systemic inflammatory response to infection...
  2. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
    ..is a major pathogenic cause of liver failure during multiple trauma, thermal injury, hemorrhagic and septic shock, and liver transplantation, which contributes significantly to multiple organ failure and mortality...
  3. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Septic shock resulting from acute bowel perforation and infection is a major cause of mortality...
  4. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..will be monitored to determine whether this protein can be used as a marker for progression of SIRS into septic shock. The mode of action of Cryab appears to be linked with the protein's role as a chaperone...
  5. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..hepatic injury is a vital component of multi-organ failure caused by complex trauma including blast injury, septic shock, and graft failure after liver transplantation often leading to death of the patient...
  6. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..circulation and blood pressure clinically significant states of hypotension, including cardiac arrest and septic shock. This novel non-invasive device is inserted within a standard respiratory circuit between the patient and a ..
  7. Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1
    RAJESH K ANEJA; Fiscal Year: 2013
    ..HMGB1 is a crucial late-acting mediator of sepsis in patients with sepsis, severe sepsis and septic shock. While much attention has been focused on the function of extracellular HMGB1, the mechanisms of HMGB1 release ..
  8. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..tissue infiltration in various model of inflammation including, streptomycin induced diabetes, LPS induced septic shock, ischemia and reperfusion injury...
  9. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..If this pathogen is not eradicated, sepsis may progress to severe sepsis (sepsis plus organ dysfunction) and septic shock (severe sepsis plus refractory hypotension and circulatory failure), which frequently leads to death...
  10. Severe H1N1 Influenza Infection During Pregnancy: Pathophysiologic Mechanisms
    Mark Phillippe; Fiscal Year: 2010
    ..storm) during pregnancy, and/or 3) the increased metabolic demands of pregnancy predisposing to hypoxia and septic shock. Although reasonable speculations, there is currently no experimental evidence supporting any of these ..
  11. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    ..problem, which determines morbidity and mortality after liver transplantation, liver surgery and hemorrhagic or septic shock. IRP injury is an even bigger issue in steatotic livers...
  12. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..a fulminant innate response that contributes importantly to end- organ damage and to lethal sequelae such as septic shock. In 1993, we cloned murine macrophage migration inhibitory factor (MIF) as an upstream regulator of innate ..
  13. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in microbial infection, septic shock and systemic inflammatory response syndrome (SIRS)...
  14. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..such as C-reactive protein and TNF-a, have been frequently used as diagnostics of systemic inflammation and septic shock. Others, including ALT, NGAL, and troponin are indicative of more specific organ damage such as liver, kidney, ..
  15. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains high. Endacea, Inc...
  16. Molecular Regulation of Ischemic Renal Failure
    Zheng Dong; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: VA RELEVANCE: A broad range of clinical conditions including dehydration, hypotension, septic shock, trauma and operative arterial clamping leads to the reduction of blood flow to the kidneys...
  17. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..This proposal addresses the mechanisms by which DC-TLR responses are altered during viral infections and thus has the potential to provide novel therapeutic strategies to fight-off opportunistic pathogens associated with viral diseases. ..
  18. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Group A streptococcus (GAS) causes a particularly severe form of septic shock termed Streptococcal Toxic Shock Syndrome (StrepTSS) and mortalities range from 30-70% despite modern medical practices...
  19. Lipid A &Innate Immune Receptors in Neisseria Infection
    Gary A Jarvis; Fiscal Year: 2013
    ..the host from bacterial infection, but its activation can also induce a proinflammatory state leading to septic shock and death...
  20. Molecular mechanism of apolipoprotein binding to lipopolysaccharides
    PAUL MICHIEL WEERS; Fiscal Year: 2013
    ..When released in the circulation, LPS cause septic shock, a major cause of death in intensive care units...
  21. L-carnitine Treatment for Vasopressor Dependent Septic Shock
    Alan E Jones; Fiscal Year: 2013
    ..The overall goal of this proposal is to investigate L-carnitine as a novel adjunctive treatment of septic shock. In this study we will test our primary hypothesis: Early adjunctive L-carnitine administration in vasopressor ..
  22. Coordination of Pathophysiologic Endothelial Cell Signaling by ROS
    Madesh Muniswamy; Fiscal Year: 2012
    ..During septic shock, an important and under-recognized signal is leukocyte-derived superoxide, which stimulates pulmonary ..
  23. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ..the enormous long term healthcare cost of treating individuals who survive an episode of severe sepsis or septic shock. An approved clinical test that forecasts the onset of sepsis would be a major medical advance in fighting this ..
  24. Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin
    Brian G Harbrecht; Fiscal Year: 2012
    ..Project Narrative Nitric oxide is synthesized in critically ill patients during septic shock, and when overproduced, can increase cellular dysfunction, tissue injury, and death...
  25. PPARgamma and PPARgamma agonists in septic shock
    Basilia Zingarelli; Fiscal Year: 2013
    ..These studies may have an impact in developing novel therapies to decrease sepsis morbidity and mortality. ..
  26. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..is being energetically pursued as a drug target for diverse disorders, from Alzheimer's disease to septic shock. We have demonstrated that there are at least three distinct structural motifs which can be used to modify a ..
  27. Mathematical Modeling of Inflammation in ARDS
    Gary F Nieman; Fiscal Year: 2010
    ..This multiple organ dysfunction often manifests as septic shock and severe lung dysfunction, referred to collectively as the acute respiratory distress syndrome (ARDS), and ..
  28. A Novel Therapy for Septic Shock
    Xiaoling Qiang; Fiscal Year: 2011
    ..SBIR Phase I/Phase II Fast-Track proposal is intended to develop a novel therapy for patients with sepsis and septic shock. Septic shock is the leading cause of death in non-cardiac intensive care units...
  29. Mathematical Modeling of Inflammation in ARDS
    Yoram Vodovotz; Fiscal Year: 2010
    ..This multiple organ dysfunction often manifests as septic shock and severe lung dysfunction, referred to collectively as the acute respiratory distress syndrome (ARDS), and ..
  30. The roles of MKP-1 in Gram-negative bacterial sepsis and colitis
    Yusen Liu; Fiscal Year: 2010
    ..inflammatory response plays an important role in the pathogenesis of a plethora of human diseases, including septic shock and inflammatory bowel disease (IBD)...
  31. Rapid, Low-Cost Cell-Sorting System for Diagnosis of Candidemia
    Scott Irwin; Fiscal Year: 2010
    ..It has been shown (Kumar et al., 2006) that there is a 7% rise per hour, after the onset of septic shock, in the mortality rate from untreated sepsis in general...
  32. Structural and Biochemical Studies of LpxC Inhibition
    Pei Zhou; Fiscal Year: 2012
    ..bacteria;it is also the active component of lipopolysaccharide that causes life- threatening Gram-negative septic shock. Lipid A biosynthesis is an essential pathway conserved in virtually all Gram-negative organisms...
  33. A Novel Therapeutic Approach for Liver Injury
    Xiaoling Qiang; Fiscal Year: 2010
    ..and reperfusion (I/R) is a major cause of liver failure after severe trauma, thermal injury, hemorrhagic and septic shock, liver resection, or liver transplantation...
  34. Modulation of Hepatocellular Function in Sepsis
    Ping Wang; Fiscal Year: 2013
    ..by applicant): Despite the increased understanding of the complex pathophysiology of sepsis, severe sepsis and septic shock still have very high significant morbidity and mortality...
  35. Innate Immune Protection by Clean Genome E. coli
    Frederick R Blattner; Fiscal Year: 2012
    ..potential for use in clinical populations, both as an intervention for serious infections including sepsis and septic shock, and as a prophylactic to reduce the chance of infection in at-risk patients...
  36. A new smart neonatal incubator for real-time detection of sepsis
    De Ann M Pillers; Fiscal Year: 2013
    ..ratio) as early as 2 hours after onset of induced endotoxemia and 14 to 18 hours earlier than clinical signs of septic shock. The breath delta value successfully discriminated systemic inflammatory response syndrome (SIRS) from no-SIRS ..
  37. Protocolized Care for Early Septic Shock (ProCESS)
    Derek C Angus; Fiscal Year: 2012
    ..the overarching hypothesis that there are 'golden hours'in the initial management of sepsis and septic shock where prompt, rigorous, standardized care can reduce unwanted downstream consequences and improve clinical ..
  38. Preservation of mucosal barrier in surgical diseases
    Xiao Di Tan; Fiscal Year: 2013
    ..complicated with the gastrointestinal mucosal injury, which can lead to the development of systemic infection, septic shock, and multiple organ failure. Restitution is an important process for repair of disrupted intestinal lining...
  39. Genomic and Translational Approaches to Neuroendocrine Switching Events
    Michael G Rosenfeld; Fiscal Year: 2013
    ..to investigate tumor translocation by sex steroid receptors, the connection between specific demethylases and septic shock will be explored, and a new strategy for screening chemical libraries is being developed...
  40. Chicago Community-Acquired Pneumonia Consortium II
    Richard G Wunderink; Fiscal Year: 2013
    ..Confirmation that qPCR correlates with mortality, septic shock, and organ failure will challenge conventional dogma that these complications are due to the host response ..
  41. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael William Donnino; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Septic shock affections over 750,000 patients each year in the United States with an estimated 250,000 deaths...
  42. Cytoskeletal regulation of endothelial barrier function by WAVE2
    Sunil K Shaw; Fiscal Year: 2010
    ..it is associated with tissue injury and serious diseases such as atherosclerosis, asthma, diabetes, septic shock and autoimmune diseases...
  43. Late cardiovascular consequences of septic shock
    Sachin Yende; Fiscal Year: 2013
    ..follow-up in an ongoing randomized clinical trial designed to assess efficacy of Protocolized Care for Early Septic Shock, (ProCESS). We will enroll 600 ProCESS subjects who are alive at hospital discharge...
  44. Regulation of Immunity and Inflammation by TIPE2
    Youhai H Chen; Fiscal Year: 2013
    ..TIPE2-deficient mice are also hypersensitive to septic shock, and TIPE2-deficient cells are hyper-responsive to Toll-like receptor (TLR) and T cell receptor (TCR) signaling...
  45. MMP-8 as a novel therapeutic target in sepsis
    Hector R Wong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Septic shock is a major public health problem in both adults and children, and consequently there is a need to develop novel targets and therapeutic strategies...
  46. Sepsis and Mediators: the Role of MFG-E8
    Ping Wang; Fiscal Year: 2010
    Despite advances in the management of the septic patient, a large number of such patients die of the ensuing septic shock and mutiple organ failure...
  47. ATF3-Mediated Transcriptional Repression of Interferon-beta
    STEVE LEE WEINSTEIN; Fiscal Year: 2010
    ..immune system mediator, IFN-?, is a critical part of the anti-viral defense and it is casually linked to lethal septic shock and some autoimmune diseases...
  48. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Peter S Tobias; Fiscal Year: 2012
    ..long-term objective of this proposal is to gain an understanding of cellular activation mechanisms involved in septic shock. Septic shock results from the severe inflammation induced by conserved and often integral structural ..
  49. CD14: Biosynthesis, Trafficking and Secretion
    DIEGO FERNANDO NINO; Fiscal Year: 2013
    ..In fact, an overwhelming inflammatory response is responsible for the transition between sepsis and septic shock and subsequently multiple organ failure, which are responsible for the majority casualties from sepsis...
  50. Actin dynamics and regulation of epithelial barrier in intestinal inflammation
    ANDREI IVANOVICH IVANOV; Fiscal Year: 2013
    ..Furthermore, dysfunctions of the gut barrier contribute to the development of other diseases such as septic shock, alcoholic liver disease and type I diabetes...
  51. Regulation of Age-Related Inflammation in Septic Shock
    Ping Wang; Fiscal Year: 2010
    ..Despite advances in the management of sepsis, a large number of such patients die of septic shock and multiple organ failure...
  52. Mechanisms of Reduced Fatty Acid Oxidation and Cardiac Dysfunction in Sepsis
    Konstantinos Drosatos; Fiscal Year: 2013
    ..can increase cardiac fatty acid oxidation and will suggest therapeutic approaches for the treatment of cardiac septic shock. Upon conclusion of the mentored phase the PI will have established a pool of data, knowledge and new skills ..
  53. Role of TLR-cfB Signaling in Sepsis
    Wei Chao; Fiscal Year: 2013
    ..Cardiovascular collapse induced by cardiac depression and profound vasodilatation represents a main feature of septic shock and contributes to its high mortality...
  54. PARP-1 is a Negative Modulator of the Heart Shock Response
    RAJESH K ANEJA; Fiscal Year: 2010
    ..PARP-1 is a nuclear enzyme that upon activation mediates progression of septic shock. Genetic deletion or pharmacological inhibition of PARP is protective in animal models of sepsis...
  55. A novel device for improving sepsis outcomes through hemodynamic optimization
    Brett D Mensh; Fiscal Year: 2013
    ..A key goal in treating patients suffering from septic shock is to normalize cardiac function while maintaining optimal fluid balance and tissue oxygenation levels...
  56. The role of MCPIP1 in regulating NF-kB signaling and macrophage activation
    Mingui Fu; Fiscal Year: 2012
    Project Summary Activated macrophages play an important role in many inflammatory diseases including septic shock and atherosclerosis. However, the molecular mechanisms limiting macrophage inflammation are not completely understood...
  57. PPAR gamma in pediatric sepsis and the inflammatory response in obesity
    JENNIFER MELISSA KAPLAN; Fiscal Year: 2013
    ..the therapeutic efficacy of PPARg ligands in the inflammatory response in ex vivo monocytes from children with septic shock;3) Determine the role of PPARg in the increased susceptibility to sepsis in obesity...
  58. Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin
    Xiaojing Ma; Fiscal Year: 2011
    ..the synthesis of IL-10 in macrophages in vitro and protect the host in systemic inflammatory disorders like septic shock. The hypothesis is that PGRN and SLPI are pivotal regulators of inflammation and tissue equilibrium through ..
  59. Role of SR-BI in LPS detoxification
    Xiang An Li; Fiscal Year: 2012
    ..Sepsis can rapidly develop to septic shock when an overwhelming infection leads to low blood pressure and multi-organs dysfunction...
  60. CHRONIC ETHANOL: MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS
    LOU ANN SCISM BROWN; Fiscal Year: 2010
    In a prospective multi-center clinical study of septic shock patients, alcoholic subjects represented about 50% of the subjects who developed the Acute Respiratory Distress Syndrome (ARDS). The relative risk in alcoholic patients was 3...
  61. PPAR?? and Alveolar Macrophage Phenotype in Acute Lung Injury
    Annette M Esper; Fiscal Year: 2013
    ..diabetes mellitus (DM) is the only identified condition shown to decrease the incidence of ALI in patients with septic shock. This unexpected observation serves as the foundation for examining ALI pathogenesis to understand disease-..
  62. Protease Activated Receptor Signaling by Coagulation Proteases
    Alireza R Rezaie; Fiscal Year: 2013
    ..e., lung and heart) which is caused by septic shock in severe sepsis...
  63. Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome
    Deborah A Buffington; Fiscal Year: 2013
    ..SCD1G to have greater therapeutic efficacy with increasing surface area (SA) in a large animal model of septic shock, when compared to sham treated controls, in addition to establishing a simplified SCD extracorporeal circuit ..
  64. Effect of Thiamine on Pyruvate Dehydrogenase Activity in Septic Shock
    Michael William Donnino; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Septic shock affections over 750,000 patients each year in the United States with an estimated 250,000 deaths...
  65. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..This number continues to grow annually. Nearly half of these septic patients develop severe sepsis and septic shock. In most hospitals more than 60% of severe sepsis patients present to the emergency department...
  66. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    ..and progression among these clinical presentations, particularly for the type of acute lung injury (ALI) and septic shock originating as pneumonic plague that will dominate epidemics following inhalation of Y...
  67. MOLECULAR MECHANISMS OF SEPTIC SHOCK
    JACK HAWIGER; Fiscal Year: 2003
    The focus of this application is molecular mechanisms of septic shock with attendant Disseminated Intravascular Coagulation (DIC) affecting annually 400,000 hospitalized patients in the US...
  68. PARP inhibitor therapy for septic shock
    Andrew Salzman; Fiscal Year: 2004
    Progression of septic shock to multiple organ failure (MOF) is mediated by the activation of poly(ADP-ribose) polymerase ("PARP"), a nuclear cell death enzyme that catalyzes intracellular energetic failure and necrosis...
  69. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..Viral bioterrorism agents such as smallpox can also induce Systemic Inflammatory Response Syndrome (SIRS) and septic shock because of secondary bacterial infections...
  70. SEQUENTIAL MODEL OF LEUKOCYTE ROLLING AND ARREST IN FLOW
    Michael Lawrence; Fiscal Year: 1999
    ..following ischemia; and has also been shown to play a role in adult respiratory distress syndrome and septic shock associated multi.organ failure...
  71. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    b>Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  72. Extracorporeal Blood Purification For Sepsis Therapy
    Susan Szathmary; Fiscal Year: 2006
    ..can result in an overwhelming systemic inflammatory response and procoagulant state leading to sepsis, septic shock and death...
  73. CONTRIBUTION OF LPS TO EXP ENTEROCOCCAL SEPSIS
    Christopher Papasian; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Severe sepsis and septic shock secondary to Gram-positive bacterial pathogen infection is increasingly recognized in a recent series of patients with sepsis from the USA and other ..
  74. Sympathetic Regulation of Endotoxemia in Drug Abuse
    MARK KNUEPFER; Fiscal Year: 2005
    ..to microbial infections in some humans, although the factors responsible for individual predisposition to septic shock in the context of drug abuse is particularly complex and poorly understood...
  75. TRAUMA & ORGAN FAILURE--ROLE OF LPS BINDING PROTEIN
    Stewart Wang; Fiscal Year: 2000
    Sepsis and septic shock are still major causes of morbidity and mortality among critically ill surgical patients...
  76. Sepsis syndrome and adenosine A2A receptor activation
    WILLIAM SCHELD; Fiscal Year: 2007
    ..are strongly protective in mouse models of endotoxemia and following live bacterial challenge resulting in septic shock. This proposal is designed to study some of the mechanisms responsibe for this protective effect, and identify ..
  77. Genomic analysis of pediatric SIRS and septic shock
    Hector Wong; Fiscal Year: 2009
    ..revision seeks to develop a point-of-care platform for measuring serum zinc concentrations in children with septic shock, the "zinc chip...