pelvic inflammatory disease

Summary

Summary: A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.

Top Publications

  1. pmc Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial
    Pippa Oakeshott
    Division of Community Health Sciences, St George s, University of London SW17 0RE
    BMJ 340:c1642. 2010
  2. ncbi Chlamydia infection, pelvic inflammatory disease, ectopic pregnancy and infertility: cross-national study
    Nicole Bender
    Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
    Sex Transm Infect 87:601-8. 2011
  3. ncbi Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease
    Harold C Wiesenfeld
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pennsylvania 15213, USA
    Obstet Gynecol 100:456-63. 2002
  4. pmc Risk of pelvic inflammatory disease following Chlamydia trachomatis infection: analysis of prospective studies with a multistate model
    Malcolm J Price
    School of Health and Population Sciences, Public Health Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Am J Epidemiol 178:484-92. 2013
  5. pmc Mycoplasma genitalium: an emerging cause of pelvic inflammatory disease
    Catherine L Haggerty
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Infect Dis Obstet Gynecol 2011:959816. 2011
  6. ncbi Chlamydia public health programs and the epidemiology of pelvic inflammatory disease and ectopic pregnancy
    Michael L Rekart
    School of Population and Public Health, University of British Columbia, Vancouver, Canada
    J Infect Dis 207:30-8. 2013
  7. ncbi The G-protein-coupled estrogen receptor (GPER) is expressed in normal human ovaries and is upregulated in ovarian endometriosis and pelvic inflammatory disease involving the ovary
    Sabine Heublein
    Department of Obstetrics and Gynaecology, Ludwig Maximilians University of Munich, Munich, Germany
    Reprod Sci 19:1197-204. 2012
  8. pmc Timing of progression from Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study
    Sereina A Herzog
    Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
    BMC Infect Dis 12:187. 2012
  9. ncbi Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies
    Sereina A Herzog
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Sex Transm Dis 39:628-37. 2012
  10. ncbi Fitz-Hugh-Curtis syndrome. Radiologic manifestation
    Akihiro Nishie
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Comput Assist Tomogr 27:786-91. 2003

Research Grants

  1. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
  2. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    Richard F Selden; Fiscal Year: 2012
  3. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
  4. Enzymology of Chlamydia Pathogenesis
    Dewey G McCafferty; Fiscal Year: 2013
  5. Lipid A &Innate Immune Receptors in Neisseria Infection
    Gary A Jarvis; Fiscal Year: 2013
  6. Prophage-associated virulence factors in pathogenic Neisseria species
    ANNA KARLS; Fiscal Year: 2009
  7. A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    Richard F Selden; Fiscal Year: 2013
  8. Gonococcal Mechanisms to Evade Host Defenses
    WILLIAM MAURICE SHAFER; Fiscal Year: 2013
  9. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
  10. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2012

Detail Information

Publications304 found, 100 shown here

  1. pmc Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial
    Pippa Oakeshott
    Division of Community Health Sciences, St George s, University of London SW17 0RE
    BMJ 340:c1642. 2010
    To determine whether screening and treating women for chlamydial infection reduces the incidence of pelvic inflammatory disease over the subsequent 12 months.
  2. ncbi Chlamydia infection, pelvic inflammatory disease, ectopic pregnancy and infertility: cross-national study
    Nicole Bender
    Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
    Sex Transm Infect 87:601-8. 2011
    ..routine data in selected countries, chlamydia control activities and rates of chlamydia infection, pelvic inflammatory disease (PID), ectopic pregnancy and infertility and to compare trends in chlamydia positivity with rates of ..
  3. ncbi Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease
    Harold C Wiesenfeld
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pennsylvania 15213, USA
    Obstet Gynecol 100:456-63. 2002
    ..Fallopian tube damage is a common complication of acute symptomatic pelvic inflammatory disease (PID), yet most women with tubal factor infertility do not have a history of acute PID...
  4. pmc Risk of pelvic inflammatory disease following Chlamydia trachomatis infection: analysis of prospective studies with a multistate model
    Malcolm J Price
    School of Health and Population Sciences, Public Health Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Am J Epidemiol 178:484-92. 2013
    ..estimate the probability that a Chlamydia trachomatis (CT) infection will cause an episode of clinical pelvic inflammatory disease (PID) and the reduction in such episodes among women with CT that could be achieved by annual screening...
  5. pmc Mycoplasma genitalium: an emerging cause of pelvic inflammatory disease
    Catherine L Haggerty
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Infect Dis Obstet Gynecol 2011:959816. 2011
    ..Mycoplasma genitalium is a sexually transmitted pathogen that is increasingly identified among women with pelvic inflammatory disease (PID)...
  6. ncbi Chlamydia public health programs and the epidemiology of pelvic inflammatory disease and ectopic pregnancy
    Michael L Rekart
    School of Population and Public Health, University of British Columbia, Vancouver, Canada
    J Infect Dis 207:30-8. 2013
    ..Since the goal of Chlamydia control is to prevent reproductive complications such as pelvic inflammatory disease and ectopic pregnancy, an understanding of recent trends in these conditions is needed to fully ..
  7. ncbi The G-protein-coupled estrogen receptor (GPER) is expressed in normal human ovaries and is upregulated in ovarian endometriosis and pelvic inflammatory disease involving the ovary
    Sabine Heublein
    Department of Obstetrics and Gynaecology, Ludwig Maximilians University of Munich, Munich, Germany
    Reprod Sci 19:1197-204. 2012
    ..Seventy-nine patients (ovarian endometriosis, n = 26; ovarian pelvic inflammatory disease [PID], n = 10; normal ovaries/endometrium, n = 30/13) were analyzed by immunohistochemistry...
  8. pmc Timing of progression from Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study
    Sereina A Herzog
    Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
    BMC Infect Dis 12:187. 2012
    b>Pelvic inflammatory disease (PID) results from the ascending spread of microorganisms from the vagina and endocervix to the upper genital tract. PID can lead to infertility, ectopic pregnancy and chronic pelvic pain...
  9. ncbi Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies
    Sereina A Herzog
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Sex Transm Dis 39:628-37. 2012
    Chlamydia screening is recommended to prevent pelvic inflammatory disease (PID)...
  10. ncbi Fitz-Hugh-Curtis syndrome. Radiologic manifestation
    Akihiro Nishie
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Comput Assist Tomogr 27:786-91. 2003
    ..To clarify radiologic findings of Fitz-Hugh-Curtis syndrome (FHCS)...
  11. ncbi Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the Pelvic Inflammatory Disease Evaluation and Clinical Health (PEACH) Randomized Trial
    Roberta B Ness
    University of Pittsburgh, Graduate School of Public Health, PA 15261, USA
    Am J Obstet Gynecol 186:929-37. 2002
    b>Pelvic inflammatory disease (PID) is a common and morbid intraperitoneal infection. Although most women with pelvic inflammatory disease are treated as outpatients, the effectiveness of this strategy remains unproven.
  12. ncbi Is Mycoplasma genitalium in women the "New Chlamydia?" A community-based prospective cohort study
    Pippa Oakeshott
    Division of Population Health Sciences and Education, St George s, University of London, UK
    Clin Infect Dis 51:1160-6. 2010
    The role of Mycoplasma genitalium in pelvic inflammatory disease is unclear. We conducted a cohort study to determine the prevalence and predictors of M...
  13. pmc Cost effectiveness of home based population screening for Chlamydia trachomatis in the UK: economic evaluation of chlamydia screening studies (ClaSS) project
    Tracy E Roberts
    Health Economics Facility, HSMC, University of Birmingham, Birmingham, Switzerland
    BMJ 335:291. 2007
    ..To investigate the cost effectiveness of screening for Chlamydia trachomatis compared with a policy of no organised screening in the United Kingdom...
  14. pmc The cost effectiveness of opportunistic chlamydia screening in England
    Elisabeth J Adams
    Modelling and Economics Unit, Health Protection Agency, 61 Colindale Avenue, Colindale, London NW9 5EQ, UK
    Sex Transm Infect 83:267-74; discussion 274-5. 2007
    ..This study aims to estimate the cost effectiveness of (a) the NCSP strategy (annual screening offer to men and women aged under 25 years) and (b) alternative screening strategies...
  15. ncbi Quantitative culture of Chlamydia trachomatis: relationship of inclusion-forming units produced in culture to clinical manifestations and acute inflammation in urogenital disease
    W M Geisler
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 184:1350-4. 2001
    ..320 ifu), and diagnoses of mucopurulent cervicitis (MPC; 2550 vs. 300 ifu) and pelvic inflammatory disease (PID; 3000 vs. 578 ifu)...
  16. pmc Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease
    Brandie D Taylor
    Department of Epidemiology, University of Pittsburgh, PA 15213, USA
    J Infect Dis 205:603-9. 2012
    Toll-like receptors (TLRs) are involved in the innate immune response. We examined whether TLR variants are associated with Chlamydia trachomatis infection among women with pelvic inflammatory disease (PID).
  17. ncbi Risk of ovarian cancer in women with pelvic inflammatory disease: a population-based study
    Hui Wen Lin
    Department of Mathematics, Soochow University, Taipei, Taiwan
    Lancet Oncol 12:900-4. 2011
    ..Prevention strategies, however, are limited. Pelvic inflammatory disease (PID) has been suggested to increase the risk of developing ovarian cancer, but the results of studies ..
  18. ncbi Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease
    M Domeika
    Institute of Clinical Bacteriology, Uppsala University, Sweden
    J Infect Dis 177:714-9. 1998
    ..protein (hsp60) and immunity to human hsp60 was examined in 129 women with laparoscopically verified pelvic inflammatory disease. An ELISA was used to detect antichlamydial IgG and IgA antibodies, IgG antibodies to recombinant human ..
  19. pmc Specific strains of Escherichia coli are pathogenic for the endometrium of cattle and cause pelvic inflammatory disease in cattle and mice
    I Martin Sheldon
    Institute of Life Science, School of Medicine, Swansea University, Singleton Park, Swansea, United Kingdom
    PLoS ONE 5:e9192. 2010
    ..b>Pelvic inflammatory disease (PID; metritis) or endometritis affects approximately 40% of cattle after parturition...
  20. ncbi Trichomonas vaginalis is associated with pelvic inflammatory disease in women infected with human immunodeficiency virus
    Prashini Moodley
    Africa Centre for Population Studies and Reproductive Health and Departments of Medical Microbiology, Durban, South Africa
    Clin Infect Dis 34:519-22. 2002
    We assessed the association between the causative agents of vaginal discharge and pelvic inflammatory disease (PID) among women attending a rural sexually transmitted disease clinic in South Africa; the role played by coinfection with ..
  21. ncbi Risk of pelvic inflammatory disease after Chlamydia infection in a prospective cohort of sex workers
    Bethan Davies
    School of Public Health, Imperial College London, London, UK
    Sex Transm Dis 40:230-4. 2013
    There is uncertainty in the risk of pelvic inflammatory disease (PID) after chlamydia infection...
  22. ncbi Fitz-Hugh-Curtis syndrome: a diagnosis to consider in women with right upper quadrant pain
    Nadja G Peter
    Craig Dalsimer Division of Adolescent Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
    Cleve Clin J Med 71:233-9. 2004
    ..the liver capsule associated with genital tract infection--occurs in up to one fourth of patients with pelvic inflammatory disease (PID)...
  23. ncbi Newest approaches to treatment of pelvic inflammatory disease: a review of recent randomized clinical trials
    Catherine L Haggerty
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Infect Dis 44:953-60. 2007
    Treatment of pelvic inflammatory disease (PID) should provide high rates of clinical and microbiological cure for a range of pathogens and should ultimately prevent reproductive morbidity...
  24. ncbi Influence of human immunodeficiency virus infection on pelvic inflammatory disease
    K L Irwin
    National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Obstet Gynecol 95:525-34. 2000
    To examine the influence of human immunodeficiency virus (HIV) infection on clinical and microbiologic characteristics of pelvic inflammatory disease (PID).
  25. ncbi [Clinical feature of Fitz-Hugh-Curtis syndrome: analysis of 25 cases]
    Hyeon Woong Yang
    Department of Internal Medicine, Eulji University College of Medicine, Eulji University Hospital, Daejeon, Korea
    Korean J Hepatol 14:178-84. 2008
    Fitz-Hugh-Curtis syndrome is defined as perihepatitis associated with pelvic inflammatory disease (PID)...
  26. ncbi What is the cost of pelvic inflammatory disease and how much could be prevented by screening for chlamydia trachomatis? Cost analysis of the Prevention of Pelvic Infection (POPI) trial
    Adamma Aghaizu
    Population Health Sciences and Education, St George s, University of London, London, UK
    Sex Transm Infect 87:312-7. 2011
    To describe healthcare settings attended by women with clinical pelvic inflammatory disease (PID), to calculate the cost of a PID episode and to estimate how many cases could be prevented in London annually at current chlamydia screening ..
  27. ncbi Trends in clinical encounters for pelvic inflammatory disease and epididymitis in a national sample of Australian general practices
    Marcus Y Chen
    Sydney Sexual Health Centre, Sydney Hospital and School of Public Health, University of Sydney, Sydney, Australia
    Int J STD AIDS 17:384-6. 2006
    Trends in the frequency of clinical encounters for pelvic inflammatory disease (PID) and epididymitis in Australian general practice were determined via a national representative study of general practice activity between 1998 and 2003...
  28. pmc The demographic, sexual health and behavioural correlates of Mycoplasma genitalium infection among women with clinically suspected pelvic inflammatory disease
    V L Short
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Sex Transm Infect 86:29-31. 2010
    Mycoplasma genitalium has been identified as a cause of pelvic inflammatory disease (PID), a clinical syndrome associated with inflammation of the female upper genital tract and serious reproductive sequelae...
  29. ncbi Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease
    Hsiu Ting Tsai
    School of Nursing, Chung Shan Medical University, Taichung, Taiwan
    Fertil Steril 91:549-55. 2009
    To detect the serum expression of cathepsin B and cystatin C and the ratio of cathepsin B to cystatin C in patients with pelvic inflammatory disease (PID) and speculate whether those are helpful indicators for the diagnosis of PID.
  30. ncbi Endometritis does not predict reproductive morbidity after pelvic inflammatory disease
    Catherine L Haggerty
    University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Am J Obstet Gynecol 188:141-8. 2003
    ..We investigated the association between endometritis and reproductive morbidity...
  31. pmc Diagnosis of pelvic inflammatory disease: time for a rethink
    I Simms
    HPA Communicable Disease Surveillance Centre, London, UK
    Sex Transm Infect 79:491-4. 2003
    To critically evaluate the available evidence base concerned with the diagnosis of pelvic inflammatory disease (PID) based on clinical presentation, and to investigate the relation between signs and symptoms and the presence of ..
  32. ncbi Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    J Infect Dis 192:129-35. 2005
    ..Azithromycin treatment dramatically reduced the inflammatory response and was highly effective in eradicating C. trachomatis from the lower and upper reproductive tract (12/12), compared with doxycycline (7/12) and placebo (3/21)...
  33. ncbi Prediction of pelvic inflammatory disease among young, single, sexually active women
    Roberta B Ness
    Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Sex Transm Dis 33:137-42. 2006
    To assess prediction strategies for pelvic inflammatory disease (PID).
  34. ncbi Endometritis: the clinical-pathologic syndrome
    Linda O Eckert
    Department of Obstetrics and Gynecology, University of Washington, Seattle, 98104 2499, USA
    Am J Obstet Gynecol 186:690-5. 2002
    ..The purpose of this study was to evaluate histologically proved endometritis as a clinical syndrome that is distinct from laparoscopically confirmed salpingitis...
  35. ncbi Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections
    J Debattista
    Centre for Molecular Biotechnology, Queensland University of Technology, 484 Adelaide Street, Gardens Point Campus, Brisbane, QLD 4000, Australia
    Immunol Lett 81:205-10. 2002
    ..in uninfected fertile controls, women with various histories of Chlamydia trachomatis infection, pelvic inflammatory disease (PID) and infertility not due to C...
  36. ncbi Epidemiology, pathogenesis and treatment of pelvic inflammatory disease
    Catherine L Haggerty
    University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Expert Rev Anti Infect Ther 4:235-47. 2006
    b>Pelvic inflammatory disease, the infection and inflammation of the female upper genital tract, is a common cause of infertility, chronic pain and ectopic pregnancy...
  37. pmc Incidence of pelvic inflammatory disease in a large cohort of women tested for Chlamydia trachomatis: a historical follow-up study
    Inger J Bakken
    Department of Preventive Health Care, SINTEF Technology and Society, Trondheim, Norway
    BMC Infect Dis 9:130. 2009
    ..Chlamydia trachomatis is a highly prevalent sexually transmitted disease. Testing rates among young Norwegian women are high. Young women diagnosed with C. trachomatis are often worried about future complications...
  38. ncbi Douching, pelvic inflammatory disease, and incident gonococcal and chlamydial genital infection in a cohort of high-risk women
    Roberta B Ness
    University of Pittsburgh, Department of Epidemiology, Graduate School of Public Health, Room A530 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Am J Epidemiol 161:186-95. 2005
    Douching has been linked to gonococcal or chlamydial cervicitis and pelvic inflammatory disease (PID) in retrospective studies...
  39. ncbi Lower quality of life among women with chronic pelvic pain after pelvic inflammatory disease
    Catherine L Haggerty
    University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Obstet Gynecol 102:934-9. 2003
    To evaluate the morbidity from chronic pelvic pain after pelvic inflammatory disease (PID).
  40. ncbi Use of pH/whiff test or QuickVue Advanced pH and Amines test for the diagnosis of bacterial vaginosis and prevention of postabortion pelvic inflammatory disease
    Georgios Charonis
    Department of Obstetrics and Gynecology, Karnsjukhuset, Skovde, Sweden
    Acta Obstet Gynecol Scand 85:837-43. 2006
    Untreated bacterial vaginosis (BV) is a risk factor for postabortion pelvic inflammatory disease (PID).
  41. ncbi [The risk of pelvic inflammatory disease associated with urogenital infection with Chlamydia trachomatis; literature review]
    A J P Boeke
    VU Medisch Centrum, Van der Boechorststraat 7, 1081 BT Amsterdam
    Ned Tijdschr Geneeskd 149:878-84. 2005
    ..To determine the rate of PID in women with genital Chlamydia trachomatis infection...
  42. ncbi Irritable bowel syndrome, chronic pelvic inflammatory disease and endometriosis
    Devinder Kumar
    Department of General Surgery, St George s Hospital, Tooting, London, UK
    Eur J Gastroenterol Hepatol 16:1251-2. 2004
    ..The symptom criteria for the diagnosis of IBS remain non specific. Similarly, pelvic inflammatory disease and endometriosis present with symptoms that may be similar to those of IBS...
  43. ncbi Sexually transmitted diseases and pelvic inflammatory disease
    R Grio
    Unit B of Gynecology, Department of Obsterics and Gynecology University of Turin, and Infant Maternal Hospital, O I R M Sant Anna, Turin, Italy
    Minerva Ginecol 56:141-7. 2004
    ..aim of this study was to determine the prevalence in the Turin area of the pathogens most implicated in pelvic inflammatory disease (PID), with particular regard to which risk factors the population taken into consideration is exposed ..
  44. ncbi Role of D-dimer testing in severe pelvic inflammatory disease: a new usable marker to assess the need for fertility-impairing surgery?
    Laura Franchi
    Department of Maternal and Child Health, OB GYN Unit, University of Parma, Parma, Italy
    Fertil Steril 94:2372-5. 2010
    b>Pelvic inflammatory disease (PID), like many other inflammatory diseases, can be characterized by an inflammation-induced activation of the coagulation cascade, resulting in the production of D-dimers...
  45. pmc The role of Chlamydia trachomatis polymorphic membrane proteins in inflammation and sequelae among women with pelvic inflammatory disease
    Brandie D Taylor
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Infect Dis Obstet Gynecol 2011:989762. 2011
    ..Seropositivity to chlamydial PmpA may represent a biomarker of increased risk of sequelae secondary to infection with C. trachomatis...
  46. ncbi Has the incidence of pelvic inflammatory disease following chlamydial infection been overestimated?
    I Simms
    Int J STD AIDS 19:285-6. 2008
  47. ncbi Diagnosis and treatment of pelvic inflammatory disease
    Catherine L Haggerty
    University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Womens Health (Lond Engl) 4:383-97. 2008
    b>Pelvic inflammatory disease (PID), the infection and inflammation of the female upper genital tract, is a common cause of infertility, chronic pain and ectopic pregnancy...
  48. ncbi Elevated plasma stromal cell-derived factor 1 protein and its gene polymorphism in patients with pelvic inflammatory disease
    Hsiu Ting Tsai
    School of Nursing, College of Nursing, Chung Shan Medical University, Taichung, Taiwan
    Reprod Sci 16:610-7. 2009
    ..the expression of plasma stromal cell-derived factor 1 and the gene polymorphism in patients with pelvic inflammatory disease and healthy controls...
  49. ncbi Chlamydia trachomatis in subfertile women undergoing uterine instrumentation. How we can help in the avoidance of iatrogenic pelvic inflammatory disease?
    Kevin Thomas
    Department of Obstetrics and Gynaecology, University of Liverpool, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Hum Reprod 17:1431-2. 2002
    ..By looking for other less invasive techniques we will be able to avoid these problems in a proportion of cases. Screening or treatment should be performed in those cases requiring uterine instrumentation...
  50. ncbi Estimation of the rate of pelvic inflammatory disease diagnoses: trends in England, 2000-2008
    Clare E French
    Microbiology and Epidemiology of STIs and HIV MESH Department, Health Protection Agency Centre for Infections, London, United Kingdom
    Sex Transm Dis 38:158-62. 2011
    b>Pelvic inflammatory disease (PID) is difficult to define and diagnose; therefore, a standardized methodology for identifying and monitoring PID diagnoses is required...
  51. ncbi Association between stroke and patients with pelvic inflammatory disease: a nationwide population-based study in Taiwan
    Po Chih Chen
    Department of Neurology and Sleep Center, Shung Ho Hospital, Taipei Medical University, Taipei, Taiwan
    Stroke 42:2074-6. 2011
    The aim of this study is to estimate the risk of stroke in a 3-year period after pelvic inflammatory disease (PID) using a nationwide population-based study.
  52. ncbi Pelvic inflammatory disease (PID) from Chlamydia trachomatis versus PID from Neisseria gonorrhea: from clinical suspicion to therapy
    F De Seta
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
    G Ital Dermatol Venereol 147:423-30. 2012
    b>Pelvic inflammatory disease (PID) is the most significant complication of sexually transmitted infections in childbearing-age women and it represents an important public health problem because of its long-term sequelae (chronic pelvic ..
  53. pmc Racial variation in toll-like receptor variants among women with pelvic inflammatory disease
    Brandie D Taylor
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto St, 513 Parran Hall, Pittsburgh, PA 15261, USA
    J Infect Dis 207:940-6. 2013
    ..Racial disparities exist in gynecological diseases. Variations in Toll-like receptor (TLR) genes may alter signaling following microbial recognition...
  54. ncbi Does bacterial vaginosis cause pelvic inflammatory disease?
    Brandie Depaoli Taylor
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Sex Transm Dis 40:117-22. 2013
    b>Pelvic inflammatory disease (PID), the infection and inflammation of the female genital tract, results in serious reproductive morbidity including infertility and ectopic pregnancy...
  55. ncbi Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors
    Christina B Rasmussen
    Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
    Cancer Causes Control 24:1459-64. 2013
    The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors.
  56. ncbi Significant association of elevated concentration of plasma YKL-40 with disease severity in patients with pelvic inflammatory disease
    Shu Hsin Lee
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Clin Lab Anal 26:136-42. 2012
    To date, no study reports the implication of YKL-40 in pelvic inflammatory disease (PID). Therefore, we investigate the levels of plasma YKL-40 in patients with PID and further associate its expression with the severity of disease.
  57. pmc Nonhuman primate models used to study pelvic inflammatory disease caused by Chlamydia trachomatis
    Jason D Bell
    Department of Obstetrics and Gynecology, University of Michigan, 1500 East Medical Center Drive, L4510, Ann Arbor, MI 48109, USA
    Infect Dis Obstet Gynecol 2011:675360. 2011
    b>Pelvic inflammatory disease (PID) is a global health concern that is associated with significant morbidity and is a major cause of infertility...
  58. ncbi Pelvic inflammatory disease in adolescents between the time of testing and treatment and after treatment for gonorrhoeal and chlamydial infection
    W L Risser
    Department of Pediatrics, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    Int J STD AIDS 23:457-8. 2012
    In incarcerated adolescents, 13% developed pelvic inflammatory disease (PID) between the time of testing and treatment for chlamydial and gonorrhoeal infection, and 13% developed PID in the 30 days following single-dose treatment for one ..
  59. pmc Detection of pelvic inflammatory disease: development of an automated case-finding algorithm using administrative data
    Catherine L Satterwhite
    Division of STD Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop E 02, Atlanta, GA 30333, USA
    Infect Dis Obstet Gynecol 2011:428351. 2011
    ICD-9 codes are conventionally used to identify pelvic inflammatory disease (PID) from administrative data for surveillance purposes. This approach may include non-PID cases...
  60. ncbi Mycoplasma genitalium in cervicitis and pelvic inflammatory disease among women at a gynecologic outpatient service
    Carina Bjartling
    Department of Obstetrics and Gynecology, Institute of Clinical Sciences, University Hospital of Skåne, Malmo, Sweden
    Am J Obstet Gynecol 206:476.e1-8. 2012
    ..We sought to analyze the prevalence and clinical manifestations of Mycoplasma genitalium infection in a heterogeneous population of women...
  61. ncbi National assessment of PID diagnosis, treatment and management in general practice: England and Wales
    I Simms
    HIV and STD Division, Communicable Disease Surveillance Centre, UK
    Int J STD AIDS 11:440-4. 2000
    A questionnaire based audit was used to evaluate the diagnosis and management of suspected pelvic inflammatory disease (PID) cases by general practitioners (GPs) in England and Wales...
  62. ncbi Time from sexually transmitted infection acquisition to pelvic inflammatory disease development: influence on the cost-effectiveness of different screening intervals
    Kenneth J Smith
    School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Value Health 10:358-66. 2007
    To prevent pelvic inflammatory disease (PID), some experts recommend screening for sexually transmitted infection (STI) every 12 months, with more frequent screening suggested in higher-risk women...
  63. ncbi Toward improving the diagnosis and the treatment of adolescent pelvic inflammatory disease in emergency departments: results of a brief, educational intervention
    Fran Balamuth
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Emerg Care 26:85-92. 2010
    To assess the utility of an abbreviated teaching tool (ATT) in improving emergency medicine pediatricians' knowledge of the diagnosis and the treatment of pelvic inflammatory disease (PID).
  64. ncbi Results of a randomized controlled trial of a brief behavioral intervention for pelvic inflammatory disease in adolescents
    Maria Trent
    Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Pediatr Adolesc Gynecol 23:96-101. 2010
    ..to examine the effectiveness of a brief behavioral intervention, provided at the time of diagnosis of pelvic inflammatory disease, on subsequent behaviors by patients who were urban adolescents in a community in which sexually ..
  65. ncbi Poor provider adherence to the Centers for Disease Control and Prevention treatment guidelines in US emergency department visits with a diagnosis of pelvic inflammatory disease
    Ting Yu Shih
    Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21209, USA
    Sex Transm Dis 38:299-305. 2011
    b>Pelvic inflammatory disease (PID) is commonly diagnosed in US emergency departments (EDs)...
  66. ncbi Pelvic inflammatory disease in adolescents
    M Rosanna Gray-Swain
    Washington University in St Louis, School of Medicine, Barnes Jewish Hospital, MO 63110 1094, USA
    Curr Opin Obstet Gynecol 18:503-10. 2006
    We discuss the epidemiology, risk factors, microbiology, diagnosis, treatment and prevention of pelvic inflammatory disease in adolescents.
  67. ncbi Missing pelvic inflammatory disease? Substantial differences in the rate at which doctors diagnose PID
    A Doxanakis
    Melbourne Sexual Health Centre, Melbourne, Victoria, Australia
    Sex Transm Infect 84:518-23. 2008
    The clinical diagnosis of pelvic inflammatory disease (PID) is subjective. Our aim was to determine if the pattern of diagnosis of PID among experienced clinicians varied compared with the diagnosis of genital warts.
  68. ncbi Enhanced erythrocyte aggregation in clinically diagnosed pelvic inflammatory disease
    Benny Almog
    Department of Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Sex Transm Dis 32:484-6. 2005
    ..The diagnosis of pelvic inflammatory disease (PID) is at times difficult because of the vague symptoms and signs, but is crucial because even mild ..
  69. ncbi Perihepatitis with pelvic inflammatory disease (PID) on MDCT: characteristic findings and relevance to PID
    Ji Young Kim
    Department of Radiology, College of Medicine, Hanyang University Hospital, 17 Haengdang dong, Sungdong gu, Seoul, 133 792, Korea
    Abdom Imaging 34:737-42. 2009
    To evaluate the prevalence and image characteristics of perihepatitis, as well as the relationship with some computed tomography (CT) manifestations of pelvic inflammatory disease (PID).
  70. ncbi Endometrial plasma cells: do they indicate subclinical pelvic inflammatory disease?
    Sharon L Achilles
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Sex Transm Dis 32:185-8. 2005
    Subclinical pelvic inflammatory disease (PID) is a common condition among women with lower genital tract infection and is believed to be responsible for a greater proportion of PID-related sequelae than acute PID...
  71. ncbi Intrauterine contraceptive devices and risk of pelvic inflammatory disease: standard of care in high STI prevalence settings
    Richard Steen
    Reprod Health Matters 12:136-43. 2004
    ..IUD use is limited in some regions, however, due to concerns about increased risk of pelvic inflammatory disease (PID) and subsequent complications such as infertility and ectopic pregnancy...
  72. ncbi The program cost and cost-effectiveness of screening men for Chlamydia to prevent pelvic inflammatory disease in women
    Thomas L Gift
    Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Sex Transm Dis 35:S66-75. 2008
    Because men transmit Chlamydia trachomatis to women, screening men to prevent pelvic inflammatory disease in women may be a viable strategy. However, the cost-effectiveness of this approach requires careful assessment.
  73. ncbi [Imaging in pelvic inflammatory disease]
    I Thomassin-Naggara
    Service de Radiologie, Hopital Tenon, AP HP, 4 rue de la Chine, 75020 Paris, France
    J Radiol 89:134-41. 2008
    This is a review of evolutive aspects in pelvic inflammatory disease (salpingitis, endometritis, pyosalpinx, tubo ovarian abscess) assessed by different imaging modalities (Ultrasound, CT, MRI and hysterosalpingography).
  74. ncbi Fitz-Hugh-Curtis syndrome after laparoscopic tubal ligation. A case report
    Sonal G Gandhi
    Department of Obstetrics and Gynecology, New York Methodist Hospital, East Pavilion, 4th Floor, 506 6th Street, Brooklyn, NY 11215, USA
    J Reprod Med 48:302-5. 2003
    ..With the increasing use and complexity of these cases, new complications will also develop. Fitz-Hugh-Curtis syndrome is an uncommon finding from the spread of infection in pelvic inflammatory disease, causing perihepatitis.
  75. pmc Vaginal douching: evidence for risks or benefits to women's health
    Jenny L Martino
    Schools of Public Health and Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Epidemiol Rev 24:109-24. 2002
  76. ncbi Emergency department management of sexually transmitted infections in US adolescents: results from the National Hospital Ambulatory Medical Care Survey
    Kathleen R Beckmann
    Department of Pediatrics, Medical College of Wisconsin, Pediatric Emergency Medicine, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    Ann Emerg Med 43:333-8. 2004
    ..Many of these adolescents present to the emergency department (ED) for their care. We describe the management of adolescent sexually transmitted infections in US EDs...
  77. ncbi Clinical eficacy of placentrex injection in pelvic inflammatory disease
    Nutan Agarwal
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi 110029
    J Indian Med Assoc 108:117-8, 122. 2010
    Combination of placentrex injection with antimicrobial therapy is a better option for treating pelvic inflammatory disease (PID) than only antimicrobial therapy; which also gives more sustained effect and lesser recurrences...
  78. ncbi Recommendations and rationale for the treatment of pelvic inflammatory disease
    Oluwatosin Jaiyeoba
    Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Expert Rev Anti Infect Ther 9:61-70. 2011
    b>Pelvic inflammatory disease (PID) is one of the most common serious infections of nonpregnant women of reproductive age. Management of PID is directed at containment of infection...
  79. pmc Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial
    J D C Ross
    Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK
    Sex Transm Infect 82:446-51. 2006
    ..prospective, randomised, double blind, parallel group, non-inferiority study compared the efficacy and safety of moxifloxacin monotherapy with ofloxacin plus metronidazole in women with uncomplicated pelvic inflammatory disease.
  80. ncbi Fitz-Hugh-Curtis syndrome caused by Chlamydia trachomatis: atypical CT findings
    Benoit Mesurolle
    AJR Am J Roentgenol 182:822-4; author reply 824. 2004
  81. ncbi Use of an institutional intervention to improve quality of care for adolescents treated in pediatric ambulatory settings for pelvic inflammatory disease
    Maria Trent
    Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Adolesc Health 39:50-6. 2006
    To evaluate the impact of a quality improvement intervention for outpatient management of pelvic inflammatory disease (PID) on provider compliance with published guidelines and to explore issues affecting patient adherence to outpatient ..
  82. pmc CT diagnosis of Fitz-Hugh and Curtis syndrome: value of the arterial phase scan
    Seung Ho Joo
    Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul 120 752, Korea
    Korean J Radiol 8:40-7. 2007
    ..We wanted to evaluate the role of the arterial phase (AP) together with the portal venous phase (PP) scans in the diagnosis of Fitz-Hugh-Curtis syndrome (FHCS) with using computed tomography (CT)...
  83. ncbi Current concepts in managing pelvic inflammatory disease
    Philippe Judlin
    Department of Gynecology, Obstetrics and Reproduction, Maternite Regionale Universitaire of NANCY, Nancy, France
    Curr Opin Infect Dis 23:83-7. 2010
    The management of pelvic inflammatory disease (PID) has significantly changed during the last two decades. Moreover, some recent bacterial findings have led to recent changes in this management.
  84. ncbi Clinical inquiries. Which tests are most useful for diagnosing PID?
    Carol E Blenning
    Oregon Health and Science University, Portland, USA
    J Fam Pract 56:216-20. 2007
  85. ncbi Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease
    Chih Chia Chang
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Clin Chem Lab Med 49:1655-60. 2011
    ..The aim of this study was to investigate the diagnostic and prognostic potential of PTX3 in pelvic inflammatory disease (PID) and correlate it with the severity and outcome of PID.
  86. ncbi Subclinical pelvic inflammatory disease and infertility
    Harold C Wiesenfeld
    Departments of Obstetrics, Gynecology and Reproductive Sciences and Pathology, Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Obstet Gynecol 120:37-43. 2012
    The reported incidence of acute pelvic inflammatory disease (PID) has decreased but rates of tubal infertility have not, suggesting that a large proportion of PID leading to infertility may be undetected...
  87. ncbi Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease
    N G Beratis
    Department of Pediatrics, University of Patras Medical School, Rion, 26504, Patras, Greece
    J Cancer Res Clin Oncol 131:371-6. 2005
    ..enzymes is increased in the peritoneal fluid of patients with gynecologic cancers compared to activity in the peritoneal fluid from normal subjects and those with pelvic inflammatory disease, and fluid from benign ovarian cysts.
  88. ncbi Possible role of ovarian epithelial inflammation in ovarian cancer
    R B Ness
    R B Ness, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Natl Cancer Inst 91:1459-67. 1999
    ..e., ectopic implantation of uterine lining tissue), and pelvic inflammatory disease, cannot be directly linked to ovulation or to hormones but do cause local pelvic inflammation...
  89. ncbi Quality of life utilities for pelvic inflammatory disease health states
    Kenneth J Smith
    Section of Decision Sciences and Clinical Systems Modeling, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Sex Transm Dis 35:307-11. 2008
    Quality of life utilities for health states associated with pelvic inflammatory disease (PID) have been estimated but not directly measured...
  90. ncbi Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease
    Hsiu Ting Tsai
    School of Nursing, Chung Shan Medical University, Taiwan
    Clin Chim Acta 412:1252-6. 2011
    To detect the expression of plasma neutrophil gelatinase associated lipocalin (NGAL) and its complex with matrix metalloproteinase-9 (MMP-9) in patients with pelvic inflammatory disease (PID).
  91. ncbi [Chlamydia trachomatis antibody in Fitz-Hugh-Curtis syndrome]
    Tae Yeal Choi
    Department of Laboratory Medicine, Hanyang University College of Medicine, Seoul, Korea
    Korean J Lab Med 28:293-8. 2008
    Fitz-Hugh-Curtis (FHC) syndrome is inflammation of the liver capsule associated with pelvic inflammatory disease. We measured Chlamydia trachomatis antibodies in 30 female patients with acute abdominal pain for diagnosis of FHC-syndrome, ..
  92. ncbi Difficulties experienced in defining the microbial cause of pelvic inflammatory disease
    D Taylor-Robinson
    Department of Medicine, Imperial College London, UK
    Int J STD AIDS 23:18-24. 2012
    ..genitalium. To some extent this is consistent with the infrequency of acute M. genitalium infections in this cohort of women...
  93. pmc Condom use and the risk of recurrent pelvic inflammatory disease, chronic pelvic pain, or infertility following an episode of pelvic inflammatory disease
    Roberta B Ness
    University of Pittsburgh, Graduate School of Public Health, 130 DeSoto St, A530 Crabtree Hall, Pittsburgh, PA 15261, USA
    Am J Public Health 94:1327-9. 2004
    Among 684 sexually active women with pelvic inflammatory disease (PID) followed up for a mean of 35 months, we related contraceptive use to self-reported PID recurrence, chronic pelvic pain, and infertility...
  94. ncbi European guideline for the management of pelvic inflammatory disease
    Jonathan Ross
    Whittall Street Clinic, Birmingham, UK
    Int J STD AIDS 18:662-6. 2007
    b>Pelvic inflammatory disease (PID) remains one of the most important consequences of sexually transmitted infections (STIs) resulting in severe morbidity and acting as the economic justification for STI screening programmes...
  95. ncbi Comparing ceftriaxone plus azithromycin or doxycycline for pelvic inflammatory disease: a randomized controlled trial
    Ricardo Francalacci Savaris
    Departamento e Serviço de Ginecologia e Obstetrícia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Obstet Gynecol 110:53-60. 2007
    To evaluate the equivalence of ceftriaxone plus doxycycline or azithromycin for cases of mild pelvic inflammatory disease (PID).
  96. ncbi Treatment of pelvic inflammatory disease
    David Eschenbach
    Clin Infect Dis 44:961-3. 2007
  97. ncbi Pelvic inflammatory disease. From diagnosis to prevention
    J Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Finland
    Dermatol Clin 16:747-56, xii. 1998
    b>Pelvic inflammatory disease (PID) refers to infection of the uterus, fallopian tubes, and adjacent pelvic structures that is not associated with surgery or pregnancy. PID causes major medical, social, and economic problems worldwide...
  98. ncbi Predictors of chronic pelvic pain in an urban population of women with symptoms and signs of pelvic inflammatory disease
    Catherine L Haggerty
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
    Sex Transm Dis 32:293-9. 2005
    The objective of this study was to assess the risk profile for chronic pelvic pain (CPP) after pelvic inflammatory disease (PID).
  99. ncbi Antibiotic therapy for acute pelvic inflammatory disease: the 2006 Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines
    Cheryl K Walker
    Department of Obstetrics and Gynecology, University of California at Davis, Sacramento, CA, USA
    Clin Infect Dis 44:S111-22. 2007
    b>Pelvic inflammatory disease (PID) is a substantial cause of reproductive morbidity in young women...
  100. ncbi Treatment of hospitalized patients with acute pelvic inflammatory disease: comparison of cefotetan plus doxycycline and cefoxitin plus doxycycline
    R L Sweet
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco
    Am J Obstet Gynecol 158:736-41. 1988
    Acute pelvic inflammatory disease remains the major medical and economic consequence of sexually transmitted diseases among young women...
  101. pmc Mycoplasma genitalium among young, urban pregnant women
    Vanessa L Short
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Infect Dis Obstet Gynecol 2010:984760. 2010
    ..As the consequences of Mycoplasma genitalium in pregnant women are unknown, we examined the relationship between prenatal M. genitalium infection and SAB...

Research Grants70

  1. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
    b>Pelvic inflammatory disease (PID), the frequent infection and inflammation of the female upper genital tract, often results in long-term sequelae, including infertility, chronic pelvic pain, ectopic pregnancy, and recurrent PID...
  2. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    Richard F Selden; Fiscal Year: 2012
    ..The clinical spectrum of GC infection includes urethritis and cervicitis, pelvic inflammatory disease (PID), and disseminated disease...
  3. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    ..C. trachomatis is an obligate intracellular pathogen of humans that causes blindness, pelvic inflammatory disease, infertility, and is an important cofactor in transmission of human immunodeficiency virus (HIV)...
  4. Enzymology of Chlamydia Pathogenesis
    Dewey G McCafferty; Fiscal Year: 2013
    ..C. trachomatis infections cause numerous disease-related complications including pelvic inflammatory disease, ectopic pregnancy, infertility, and blindness...
  5. Lipid A &Innate Immune Receptors in Neisseria Infection
    Gary A Jarvis; Fiscal Year: 2013
    ..Neisserial infections, leading to exaggerated responses such as meningococcal sepsis and gonococcal pelvic inflammatory disease. Thus, in the studies proposed herein, we seek to define the LA structural elements that determine ..
  6. Prophage-associated virulence factors in pathogenic Neisseria species
    ANNA KARLS; Fiscal Year: 2009
    ..vaccines and therapeutics for Neisseria gonorrhoeae (gonococci, GC), which causes gonorrhoeae and pelvic inflammatory disease, and Neisseria meningitidis (meningococci, MC), which causes septicemia and meningitis...
  7. A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    Richard F Selden; Fiscal Year: 2013
    ..8 million US cases annually. Currently, 40% of women with untreated infection will develop pelvic inflammatory disease (PID), 20% of whom will become infertile, 18% will experience debilitating, chronic pelvic pain, and 9% ..
  8. Gonococcal Mechanisms to Evade Host Defenses
    WILLIAM MAURICE SHAFER; Fiscal Year: 2013
    ..localized uncomplicated infections at mucosal surfaces and more invasive forms of disease including pelvic inflammatory disease and bloodstream infections...
  9. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
    ..manifested as urethritis or cervicitis, the gonococcus can cause serious complications, including pelvic inflammatory disease (PID), the leading cause of sterility in women, and disseminated gonococcal infection (DGI), a leading ..
  10. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2012
    ..blindness, and a wide range of sexually transmitted diseases including cervicitis, salpingitis, pelvic inflammatory disease, and infertility in females and non-gonococcal arthritis and acute epididymitis in males...
  11. The influence of negative regulators of inflammation on C. trachomatis infections
    DAVID MARCELO OJCIUS; Fiscal Year: 2010
    ..Yet, inflammation is also responsible for pelvic inflammatory disease and scarring of fallopian tubes that can lead to infertility, ectopic pregnancy and chronic pelvic pain...
  12. Molecular Epidemiology of the Vaginal Microbiome
    Rebecca M Brotman; Fiscal Year: 2013
    ..including preterm birth, acquisition of sexually transmitted infections and HIV, and development of pelvic inflammatory disease. National surveys indicate the prevalence of BV among U.S...
  13. The Role of Uncultivated Bacteria in Bacterial Vaginosis
    DAVID NEAL FREDRICKS; Fiscal Year: 2013
    ..BV) have increased risks of acquiring sexually transmitted infections such as HIV, developing pelvic inflammatory disease, and experiencing preterm birth...
  14. Recombination in a Minimal Organism
    Patricia A Totten; Fiscal Year: 2013
    ..in men and is becoming increasingly recognized for its etiologic role in cervicitis, endometritis, pelvic inflammatory disease, tubal factor infertility, and preterm birth in women...
  15. Development of a Chlamydia T Cell Vaccine Based on Dendritic Cell Immunoprotemics
    Leonard J Foster; Fiscal Year: 2012
    ..8 million infections in America alone. Chlamydia trachomatis can cause pelvic inflammatory disease, ectopic pregnancy and infertility in women and is a co- factor in HIV transmission...
  16. Novel Bacterial Pathogens in Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2012
    b>Pelvic Inflammatory Disease (PID) is a common disease among young women that results in serious sequelae including infertility, recurrence, and chronic pelvic pain...
  17. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2013
    ..blindness, and a wide range of sexually transmitted diseases including cervicitis, salpingitis, pelvic inflammatory disease, and infertility in females and non-gonococcal urethritis and acute epididymitis in males...
  18. The interaction of Chlamydia with the host cytoskeleton
    Scott S Grieshaber; Fiscal Year: 2012
    ..chlamydial genital tract infection is approximately 4 million annually, causing severe illness such as pelvic inflammatory disease leading to tubal infertility...
  19. Recombination and Genetics in Chlamydia spp.
    Daniel D Rockey; Fiscal Year: 2010
    ..tract in humans, and complications from these infections lead to chronic problems including trachoma, pelvic inflammatory disease, ectopic pregnancy, and perhaps other conditions...
  20. Factors Mediating Host Resistance to Chlamydia trachomatis
    Michael N Starnbach; Fiscal Year: 2013
    ..Chronic genital infections with C. trachomatis can lead to pelvic inflammatory disease, infertility, and other complications in women. Our overall goal in this grant is to define how C...
  21. Rapid and Cost-Effective Diagnostic System for Sexually Transmitted Infections
    John E Mueller; Fiscal Year: 2011
    ..STIs) in the US, causing serious long term health problems such as sepsis, stricture disease, pelvic inflammatory disease (PID), ectopic pregnancy and infertility...
  22. T-bet regulates CD4 memory to bacterial infection with C. trachomatis
    David Gondek; Fiscal Year: 2010
    ..trachomatis poses serious health risks to women including ectopic pregnancy, pelvic inflammatory disease (PID), and infertility...
  23. Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis infection
    Loris Y Hwang; Fiscal Year: 2012
    ..However, over-zealous inflammation can lead to serious sequelae including pelvic inflammatory disease and infertility...
  24. The Microbial Ecology of Bacterial Vaginosis: A Fine Scale Resolution Metagenomic
    Jacques Ravel; Fiscal Year: 2011
    ..and low infant birth weight, acquisition of sexually transmitted infections and HIV, and development of pelvic inflammatory disease. National surveys indicate the prevalence of BV among U.S. women is 29...
  25. Female Genital Innate Immune Response to Vaginal Microbiota
    Caroline M Mitchell; Fiscal Year: 2013
    ..of anaerobic vaginal bacteria, and is associated with several adverse clinical outcomes, including pelvic inflammatory disease, preterm birth and increased risk of HIV-1 acquisition...
  26. Effects of a chlamydial ATP-consuming enzyme on the inflammasome
    MARIA LUISA AVILA; Fiscal Year: 2010
    ..is required for elimination of chlamydial infection, but inflammation is also responsible for pelvic inflammatory disease and scarring of upper genital tract fallopian tubes which can lead to infertility, ectopic pregnancy (a ..
  27. Molecular Analyses of MG Pathogenesis in Human Cell Culture and Mouse Models
    Richard B Pyles; Fiscal Year: 2010
    ..many as 25% of urethritis patients and is highly associated with non-gonococcal urethritis in men and pelvic inflammatory disease, cervicitis and tubal factor infertility in women...
  28. Mechanism(s) of CD8 T cell-mediated Chlamydia-induced reproductive pathology
    ASHLESH KRISHNA MURTHY; Fiscal Year: 2013
    ..In untreated women, these infections cause serious sequelae such as pelvic inflammatory disease and ectopic pregnancy, often resulting in infertility...
  29. Primate Model of Mycoplasma genitalium
    Patricia A Totten; Fiscal Year: 2010
    ..cause of reproductive tract disease syndromes, including urethritis, mucopurulent cervicitis, pelvic inflammatory disease, endometritis, preterm birth, with possible sequelae that include infertility, chronic pelvic pain, ..
  30. T-cell mediated immunity in chlamydia genital infection
    Kathleen A Kelly; Fiscal Year: 2012
    ..Three million new cases of infection occur in the US each year and commonly result in pelvic inflammatory disease (PID), ectopic pregnancy and tubal infertility which costs the health care industry billions of dollars ..
  31. Mycoplasma genitalium Antigenic Variation
    Patricia Totten; Fiscal Year: 2009
    ..genitalium is a newly recognized cause of urethritis in men and possibly cervicitis, endometritis, pelvic inflammatory disease, involuntary sterility, and preterm birth in women...
  32. Type IV secretion by Neisseria gonorrhoeae
    Joseph P Dillard; Fiscal Year: 2012
    ..Neisseria gonorrhoeae is the causative agent of the sexually-transmitted disease gonorrhea as well as pelvic inflammatory disease, and disseminated gonococcal infection...
  33. Evaluation of CPAF Mediated Anti-Chlamydial Immunity in the Guinea Pig
    BERNARD PRAGASH ARULANANDAM; Fiscal Year: 2012
    ..Untreated genital chlamydial infections cause serious sequelae such as pelvic inflammatory disease, ectopic pregnancy, and infertility...
  34. Scanning Chlamydia proteome for vaccine antigens
    Luis M de la Maza; Fiscal Year: 2010
    ..In symptomatic cases, unless therapy is implemented in a timely manner, long-term sequelae including, pelvic inflammatory disease, chronic abdominal pain, ectopic pregnancy and infertility, may develop...
  35. Interaction of Neisseria gonorrhoeae with polarized human endocervical epithelial
    Wenxia Song; Fiscal Year: 2013
    ..The silent infection allows the bacteria to disseminate, which can lead to pelvic inflammatory disease (PID), a leading cause of ectopic pregnancy and infertility...
  36. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis O Eko; Fiscal Year: 2013
    ..the most common bacterial cause of STDs and if untreated often lead to severe complications, including pelvic inflammatory disease, ectopic pregnancy and infertility in women...
  37. Anti-adhesive prevention of Chlamydia trachomatis genital tract infection
    Lee Ann Campbell; Fiscal Year: 2010
    ..consequences of untreated infections may result in severe reproductive tract disease including pelvic inflammatory disease (PID), ectopic pregnancy and infertility...
  38. Advancing research on the sexually transmitted female 'nuisance' pathogen Trichom
    Jane Carlton; Fiscal Year: 2010
    ..Acute infections among women are associated with pelvic inflammatory disease and adverse pregnancy outcomes. Most alarming is the recognition that T...
  39. Mycoplasma genitalium variation in longitudinally infected men
    Patricia A Totten; Fiscal Year: 2013
    ..in men and is becoming increasingly recognized for its etiologic role in cervicitis, endometritis, pelvic inflammatory disease, tubal factor infertility, and preterm birth in women...
  40. Mycoplasma Genitalium and Pelvic Inflammatory Disease
    Catherine L Haggerty; Fiscal Year: 2010
    DESCRIPTION (provided by investigator): Pelvic inflammatory disease (PID), the frequent infection and inflammation of the female upper genital tract, often results in long-term sequelae, including infertility, chronic pelvic pain, ..
  41. Genetic Variation in genes involved in Neisseria gonorrhoeae LOS biosynthesis
    Daniel C Stein; Fiscal Year: 2013
    ..Gonococcal infections can disseminate, from the initial site of infection causing pelvic inflammatory disease (PID), which can lead to tubal infertility, ectopic pregnancy, and chronic pelvic pain, or into the ..
  42. Development of Bacterial Therapeutics Targeting Bacterial Vaginosis-Associated Bi
    Qiang Xu; Fiscal Year: 2010
    ..disease burden of adverse obstetric and gynecologic outcomes, including adverse pregnancy outcomes and pelvic inflammatory disease. BV resembles a sexually transmitted disease (STD) and is positively associated with the acquisition of ..
  43. Technology Enhanced Community Health Nursing to Reduce Recurrent STIs after PID
    Maria E Trent; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pelvic Inflammatory Disease (PID) remains a serious reproductive health disorder and disease rates remain unacceptably high among minority adolescent girls and young adult women...
  44. CPAF induced CD4+ T cell mediated immunity against Chlamydia
    BERNARD PRAGASH ARULANANDAM; Fiscal Year: 2013
    ..Untreated genital chlamydial infection cause serious sequelae such as pelvic inflammatory disease, ectopic pregnancy, and infertility...
  45. Novel Cultivation Methods for the Domestication of Vaginal Bacteria
    DAVID NEAL FREDRICKS; Fiscal Year: 2012
    ..and is associated with increased risk of sexually transmitted diseases, including HIV, preterm birth, pelvic inflammatory disease, and several other adverse outcomes...
  46. LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeae
    Pei Zhou; Fiscal Year: 2013
    ..S., with over 350,000 cases reported in 2007. N. gonorrhoeae is a major cause of pelvic inflammatory disease, can increase the possibility of ectopic pregnancy, and is associated with an increased rate of ..
  47. Cell separation in Neisseria gonorrhoeae
    Joseph P Dillard; Fiscal Year: 2013
    ..transmitted disease in men and women that often results in severe consequences for women including pelvic inflammatory disease, ectopic pregnancy, and infertility...
  48. Universal Screening of HIV-Infected Persons for Gonorrhea and Chlamydia
    STEPHEN ARTHUR BERRY; Fiscal Year: 2013
    ..has the potential to decrease HIV transmission and reduce adverse outcomes of GC and CT such as pelvic inflammatory disease. Despite these potential benefits and screening guidelines issued by the Centers for Disease Control ..
  49. Eco-Pathogenomics of Chlamydial Reproductive Tract Infection (EPCRTI)
    Jacques Ravel; Fiscal Year: 2013
    ..trachomatis infection and C. trachomatis-pos\t\\/e women with pelvic inflammatory disease (PID)...
  50. A molecular switch of the type III secretion system in Chlamydia trachomatis
    Li Shen; Fiscal Year: 2012
    ..The severe sequelae of genital chlamydial infections in women include pelvic inflammatory disease, ectopic pregnancy and tubal infertility. A key virulence mechanism of C...
  51. Immunomodulation and Vaccine Optimization against Chlamydia
    Qing He; Fiscal Year: 2013
    ..Complications in women include pelvic inflammatory disease, ectopic pregnancy and involuntary tubal factor infertility...
  52. Peptidoglycan metabolism and fragment release
    Joseph P Dillard; Fiscal Year: 2013
    ..In the organ culture model of gonococcal pelvic inflammatory disease, these peptidoglycan fragments recapitulate the tissue damage seen in women with the disease...
  53. Identifying Biomarkers and Genetic Risk Factors Predictive of Reproductive Sequel
    Toni Darville; Fiscal Year: 2013
    ..infection and reproductive tract sequelae in women exposed to sexually transmitted pathogens that cause pelvic inflammatory disease (PID)...
  54. Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne M Marrazzo; Fiscal Year: 2010
    Bacterial vaginosis (BV) is a common cause of vaginitis and increases women's risk of pelvic inflammatory disease, adverse pregnancy outcomes, and risk of HIV acquisition...
  55. Chlamydia co-option of Eukaryotic Lipid Droplets
    Raphael H Valdivia; Fiscal Year: 2010
    ..pathogens that cause a range of acute and chronic diseases including trachoma, conjunctivitis, pelvic inflammatory disease and atypical pneumonias...
  56. A novel vaccine against vaginal Chlamydia trachomatis
    MICHAEL SEJR VAJDY; Fiscal Year: 2013
    ..of an effective vaccine would not only reduce the morbidity associated with these infections, including pelvic inflammatory disease (PID), infertility, chronic pelvic pain and ectopic pregnancy, but could also reduce collateral riss ..
  57. AB SCIEX QTRAP 5500 LC MS/MS system
    BRADFORD WAYNE GIBSON; Fiscal Year: 2010
    ..of cancer, determining the role of mitochondrial dysfunction in aging and age-related diseases, and the analysis of the bacterial biofilms that form in some human diseases, such as chronic ear infections and pelvic inflammatory disease.
  58. Salpingeal infection model of Mycoplasma genitalium
    Patricia A Totten; Fiscal Year: 2010
    ..cause of reproductive tract disease syndromes, including urethritis, mucopurulent cervicitis, pelvic inflammatory disease, and endometritis, with possible sequelae that include infertility, chronic pelvic pain, and preterm ..
  59. IRGM-driven host responses to Chlamydia trachomatis infections
    JOERN COERS; Fiscal Year: 2013
    ..The infection can persist for years and chronic infections ultimately result in pelvic inflammatory disease, ectopic pregnancies, and infertility. Whereas some individuals clear infections with C...
  60. Repeated Bacterial STIS Among Heterosexual Men
    Patricia J Kissinger; Fiscal Year: 2010
    ..infections with Chlamydia trachomatis (CT) are associated with serious reproductive outcomes such as pelvic inflammatory disease, ectopic pregnancy, chronic pelvic pain, and infertility...
  61. Role of CD8+ T cells in Reproductive Sequelae Induced by Chlamydia Infection
    ASHLESH KRISHNA MURTHY; Fiscal Year: 2011
    ..Untreated genital chlamydial infections cause serious sequelae such as pelvic inflammatory disease, ectopic pregnancy, and infertility...
  62. Pathogenesis of Persistent Chlamydial STDs
    Deborah Dean; Fiscal Year: 2007
    ..CT infections and their sequelae of pelvic inflammatory disease, ectopic pregnancy, and infertility are responsible for ~80% of the estimated $2...
  63. CHLAMYDIA TRACHOMATIS ENVELOPE COMPONENTS AND VIRULENCE
    JANE RAULSTON; Fiscal Year: 2003
    ..in the United States and a major culprit in urethritis, cervicitis, endometritis, salpingitis, pelvic inflammatory disease, infertility and ectopic pregnancy...
  64. A RCT of LNG-IUD vs. DMPA for young postpartum women
    Nancy Stanwood; Fiscal Year: 2005
    ..considered in this population due to a false perception that IUDs lead to a long-term increased risk of pelvic inflammatory disease (PID)...
  65. EFFECTIVENESS OF OUTPATIENT TREATMENT FOR PID
    Roberta Ness; Fiscal Year: 1999
    b>Pelvic inflammatory disease (PID) affects over one million American women every year. It frequently results in infertility, ectopic pregnancy, chronic pelvic pain and recurrence...
  66. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2003
    ..pathogens involved in the majority of cases of bacterial sexually transmitted genital infection and pelvic inflammatory disease (PID). We have shown that the forms of C3 bound to N...
  67. Inflammatory Markers in Circulation and Ovarian Cancer Risk
    Alan Arslan; Fiscal Year: 2009
    ..Several risk factors implicated in ovarian cancer development such as pelvic inflammatory disease, endometriosis, and incessant ovulation, an inflammation-like process, support the hypothesis that ..
  68. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
    ..pathogen Neisseria gonorrhoeae produces an array of diseases ranging from urethritis and cervicitis to pelvic inflammatory disease. Early events in the establishment of infection involve interactions between N...
  69. A High Accuracy Point-of-Care Chlamydia trachomatis Test
    Michael Helms; Fiscal Year: 2004
    ..Sequelae include urethritis, cervicitis, salpingitis (which can lead to infertility in women), pelvic inflammatory disease, adverse pregnancy outcomes (e.g...
  70. INTRACELLULAR FATE OF NEISSERIA GONORRHOEAE
    Richard Rest; Fiscal Year: 2000
    ..Gonorrhea, and its dramatically more serious complications, salpingitis and PID (pelvic inflammatory disease), which may lead to sterility and ectopic pregnancy, cost the US healthcare system over $1 billion in ..