reactive arthritis

Summary

Summary: An abacterial form of arthritis developing after infection at a site distant from the affected joint or joints. The causative bacteria cannot be cultured from synovial specimens but bacterial antigens have been demonstrated in cells from the synovial fluid and membrane. It often follows Yersinia infection.

Top Publications

  1. ncbi Campylobacter-triggered reactive arthritis: a population-based study
    T Hannu
    Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland
    Rheumatology (Oxford) 41:312-8. 2002
  2. pmc Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics
    R Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Exp Immunol 148:486-93. 2007
  3. ncbi Reactive arthritis after enteric infections in the United States: the problem of definition
    John M Townes
    Division of Infectious Diseases, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Clin Infect Dis 50:247-54. 2010
  4. ncbi Reactive arthritis and other sequelae following sporadic Salmonella typhimurium infection in British Columbia, Canada: a case control study
    Jane A Buxton
    British Columbia Centre for Disease Control Society, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada
    J Rheumatol 29:2154-8. 2002
  5. ncbi Reactive arthritis and other musculoskeletal sequelae following an outbreak of Salmonella hadar in Castellon, Spain
    Alberto Arnedo-Pena
    Epidemiology Division, Public Health Center, Castellon, Spain
    J Rheumatol 37:1735-42. 2010
  6. ncbi Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis
    Rainer H Straub
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 46:654-62. 2002
  7. ncbi Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study
    J M Townes
    Oregon Health and Science University, Mailcode L457, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239 3098, USA
    Ann Rheum Dis 67:1689-96. 2008
  8. ncbi Incidence and prevalence of psoriatic arthritis, ankylosing spondylitis, and reactive arthritis in the first descriptive population-based study in the Czech Republic
    P Hanova
    Institute of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic
    Scand J Rheumatol 39:310-7. 2010
  9. pmc Campylobacter reactive arthritis: a systematic review
    Janet E Pope
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, Ontario, Canada
    Semin Arthritis Rheum 37:48-55. 2007
  10. ncbi Reactive arthritis: clinical aspects and medical management
    John D Carter
    Department of Internal Medicine, Division of Rheumatology, University of South Florida, 12901 Bruce B Downs Boulevard, MDC 81, Tampa, FL 33612, USA
    Rheum Dis Clin North Am 35:21-44. 2009

Detail Information

Publications213 found, 100 shown here

  1. ncbi Campylobacter-triggered reactive arthritis: a population-based study
    T Hannu
    Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland
    Rheumatology (Oxford) 41:312-8. 2002
    To study the incidence and clinical picture of Campylobacter-associated reactive arthritis (ReA) and other reactive musculoskeletal symptoms in the population.
  2. pmc Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics
    R Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Exp Immunol 148:486-93. 2007
    In patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA), synovial fluid mononuclear cells (SFMC) show proliferation to bacterial antigens that trigger ReA, i.e...
  3. ncbi Reactive arthritis after enteric infections in the United States: the problem of definition
    John M Townes
    Division of Infectious Diseases, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Clin Infect Dis 50:247-54. 2010
    ..b>Reactive arthritis (ReA) is a poorly defined term that is used to describe a variety of rheumatologic phenomena that may occur ..
  4. ncbi Reactive arthritis and other sequelae following sporadic Salmonella typhimurium infection in British Columbia, Canada: a case control study
    Jane A Buxton
    British Columbia Centre for Disease Control Society, Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada
    J Rheumatol 29:2154-8. 2002
    ..To describe sequelae occurring in the 3 months after sporadic Salmonella typhimurium (ST) infection in British Columbia (BC), Canada...
  5. ncbi Reactive arthritis and other musculoskeletal sequelae following an outbreak of Salmonella hadar in Castellon, Spain
    Alberto Arnedo-Pena
    Epidemiology Division, Public Health Center, Castellon, Spain
    J Rheumatol 37:1735-42. 2010
    ..We estimated the incidence and risk factors for reactive arthritis (ReA) and other musculoskeletal sequelae in the patients of this outbreak in 2 health departments of ..
  6. ncbi Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis
    Rainer H Straub
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 46:654-62. 2002
    ..to cytokines and to study levels of cortisol or dehydroepiandrosterone (DHEA) in relation to other adrenal hormones in untreated patients with early rheumatoid arthritis (RA) and reactive arthritis (ReA) compared with healthy controls.
  7. ncbi Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study
    J M Townes
    Oregon Health and Science University, Mailcode L457, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239 3098, USA
    Ann Rheum Dis 67:1689-96. 2008
    To describe the epidemiology and clinical spectrum of reactive arthritis (ReA) following culture-confirmed infection with bacterial enteric pathogens in a population-based study in the USA.
  8. ncbi Incidence and prevalence of psoriatic arthritis, ankylosing spondylitis, and reactive arthritis in the first descriptive population-based study in the Czech Republic
    P Hanova
    Institute of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic
    Scand J Rheumatol 39:310-7. 2010
    To estimate the annual incidence and prevalence of psoriatic arthritis (PsA), ankylosing spondylitis (AS), and reactive arthritis (ReA) in a sample of the Czech population.
  9. pmc Campylobacter reactive arthritis: a systematic review
    Janet E Pope
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, Ontario, Canada
    Semin Arthritis Rheum 37:48-55. 2007
    To review the literature on the epidemiology of Campylobacter-associated reactive arthritis (ReA).
  10. ncbi Reactive arthritis: clinical aspects and medical management
    John D Carter
    Department of Internal Medicine, Division of Rheumatology, University of South Florida, 12901 Bruce B Downs Boulevard, MDC 81, Tampa, FL 33612, USA
    Rheum Dis Clin North Am 35:21-44. 2009
    b>Reactive arthritis (ReA) is an inflammatory arthritis that arises after certain gastrointestinal or genitourinary infections, representing a classic interplay between host and environment...
  11. ncbi Reiter's syndrome (reactive arthritis) and travelers' diarrhea
    Johnnie A Yates
    CIWEC Clinic Travel Medicine Center, Kathmandu, Nepal
    J Travel Med 13:54-6. 2006
    Reiter's syndrome [also called reactive arthritis (ReA)] is the triad of arthritis, urethritis, and conjunctivitis. Two cases of Reiter's syndrome triggered by travelers' diarrhea are presented...
  12. ncbi Diagnosing reactive arthritis: role of clinical setting in the value of serologic and microbiologic assays
    Joachim Sieper
    University Hospital Benjamin Franklin, Hindenburgdamm 30, Berlin 12200, Germany
    Arthritis Rheum 46:319-27. 2002
  13. ncbi New insights into bacterial persistence in reactive arthritis
    D Astrauskiene
    Department of Rheumatology, Institute of Experimental and Clinical Medicine at Vilnius University, Lithuania
    Clin Exp Rheumatol 25:470-9. 2007
    Persistence of arthritis-triggering bacteria can cause chronization of reactive arthritis (ReA)...
  14. pmc Comparison of rheumatological and gastrointestinal symptoms after infection with Campylobacter jejuni/coli and enterotoxigenic Escherichia coli
    H Locht
    Department of Autoimmunology, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Ann Rheum Dis 61:448-52. 2002
    ..To compare gastrointestinal symptoms, antibiotic treatment, and antibody levels among patients with and without joint symptoms...
  15. ncbi Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain-Barré and reactive arthritis patients
    C W Ang
    Department of Medical Microbiology, Academic Medical Center, Amsterdam, Department of Medical Microbiology, Reinier de Graad Gasthuis, Delft, The Netherlands
    Clin Microbiol Infect 13:915-22. 2007
    ..infection, a small proportion of infected individuals develop Guillain-Barré syndrome (GBS) or reactive arthritis (ReA)...
  16. pmc Low incidence of reactive arthritis in children following a salmonella outbreak
    M Rudwaleit
    Section of Rheumatology, Department of Medicine, University Hospital Benjamin Franklin, Berlin, Germany
    Ann Rheum Dis 60:1055-7. 2001
    To assess the incidence of reactive arthritis (ReA) in an outbreak of salmonella infection in a large cohort of children in Germany.
  17. ncbi Role of bacteria and HLA-B27 in the pathogenesis of reactive arthritis
    David Yu
    Division of Rheumatology, University of California at Los Angeles, 35 40 Rehab Center, 1000 Veterans Avenue, Los Angeles, CA 90095, USA
    Rheum Dis Clin North Am 29:21-36, v-vi. 2003
    Strictly speaking, "reactive arthritis" is a conventional term with no study-verified definition...
  18. ncbi A comparison of self-reported joint symptoms following infection with different enteric pathogens: effect of HLA-B27
    Peter Schiellerup
    Department of Gastrointestinal Infections, Statens Serum Institut, Copenhagen, Denmark
    J Rheumatol 35:480-7. 2008
    ....
  19. ncbi Neutrophils of healthy subjects with a history of reactive arthritis show enhanced responsiveness, as defined by CD11b expression in adherent and non-adherent whole blood cultures
    K Kuuliala
    Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland
    Rheumatology (Oxford) 46:934-7. 2007
    To study innate immune responsiveness of HLA-B27 positive subjects recovered from Yersinia-triggered reactive arthritis (B27 + ReA+).
  20. pmc Characterisation of autoantibodies to neutrophil granule constituents among patients with reactive arthritis, rheumatoid arthritis, and ulcerative colitis
    H Locht
    Department of Autoimmunology, Statens Serum Institute, DK 2300 Copenhagen S, Denmark
    Ann Rheum Dis 59:898-903. 2000
    To study the frequency and distribution of antineutrophil cytoplasmic autoantibodies (ANCA) among patients with reactive arthritis (ReA), rheumatoid arthritis (RA), and ulcerative colitis (UC) using different immunological methods.
  21. pmc Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27
    Sanna Vähämiko
    Department of Bacterial and Inflammatory Diseases, National Public Health Institute, Turku, Finland
    Arthritis Res Ther 7:136-41. 2005
    ..One of these diseases is reactive arthritis (ReA), which is typically triggered by Gram-negative bacteria, which have lipopolysaccharide as an integral ..
  22. ncbi The evolving story of Chlamydia-induced reactive arthritis
    John D Carter
    Division of Rheumatology, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Curr Opin Rheumatol 22:424-30. 2010
    ..insights into our understanding of the epidemiology, pathophysiology, and treatment of Chlamydia-induced reactive arthritis (CiReA)...
  23. ncbi Sporadic enteric reactive arthritis and undifferentiated spondyloarthropathy: evidence for involvement of Salmonella typhimurium
    Rajesh Sinha
    Department of Immunology and Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 30:105-13. 2003
    To define the candidate bacterial trigger and cytokine profile of synovial fluid mononuclear cells (SFMC) in patients with sporadic enteric reactive arthritis (ReA) and undifferentiated spondyloarthropathy (uSpA).
  24. ncbi Reactive arthritis--the appropriate name
    Yoav Keynan
    Department of Medicine, Lady Davis Carmel Medical Center, Technion lsrael Institute of Technology, Haifa, Israel
    Isr Med Assoc J 10:256-8. 2008
    ..the entire medical profession and it was therefore suggested that the term Reiter's syndrome be changed to reactive arthritis. We undertook to investigate the use of the eponym Reiter syndrome in medical literature, medical schools in ..
  25. pmc Effect of a three month course of ciprofloxacin on the outcome of reactive arthritis
    T Yli-Kerttula
    Department of Medicine, Turku University, Finland
    Ann Rheum Dis 59:565-70. 2000
    Treatment of reactive arthritis (ReA) with antibiotics has so far remained controversial. Eradication of the causative microbe appears logical, but short term antibiotic treatment has no beneficial effect on the outcome of ReA.
  26. pmc Shigella induced reactive arthritis
    J S Hill Gaston
    University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ
    Ann Rheum Dis 64:517-8. 2005
  27. pmc Effect of a three month course of ciprofloxacin on the late prognosis of reactive arthritis
    T Yli-Kerttula
    Department of Medicine, Turku University, Satalinna Hospital, Finland
    Ann Rheum Dis 62:880-4. 2003
    The value of antibiotics in the treatment of reactive arthritis (ReA) is still controversial.
  28. pmc Comparing 10-day and 4-month doxycycline courses for treatment of Chlamydia trachomatis-reactive arthritis: a prospective, double-blind trial
    N Putschky
    Rheumatologikum Hannover, Rathenaustr 13 14, 30159 Hannover, Germany
    Ann Rheum Dis 65:1521-4. 2006
    To compare the efficacy of a 10-day and a 4-month doxycylcine course for the treatment of Chlamydia trachomatis-reactive arthritis (Ct-ReA).
  29. pmc Antibiotic treatment and long term prognosis of reactive arthritis
    K Laasila
    Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Ann Rheum Dis 62:655-8. 2003
    To evaluate whether a three month course of lymecycline has an effect on the long term prognosis of reactive arthritis (ReA).
  30. ncbi Identification of HLA-B27-restricted peptides in reactive arthritis and other spondyloarthropathies: computer algorithms and fluorescent activated cell sorting analysis as tools for hunting of HLA-B27-restricted chlamydial and autologous crossreactive pep
    Wolfgang Kuon
    Section of Rheumatology, FU Klinikum Benjamin Franklin, Berlin Hindenburgdamm 30, 12200 Berlin, Germany
    Rheum Dis Clin North Am 29:595-611. 2003
    ....
  31. ncbi Similarity between chronic reactive arthritis and ankylosing spondylitis.A 32-35-year follow-up study
    K Kaarela
    Rheumatism Foundation Hospital, Heinola, Finland
    Clin Exp Rheumatol 27:325-8. 2009
    We assessed the long-term outcome of recent reactive arthritis (ReA) during 1973-2007 and ankylosing spondylitis (AS) during 1973-1997 to identify similarities in manifestations of disease.
  32. ncbi Update on spondyloarthropathies
    Muhammad Asim Khan
    Case Western Reserve University, MetroHealth Medical Center, Division of Rheumatology, Cleveland, Ohio 44109, USA
    Ann Intern Med 136:896-907. 2002
    ..and overlapping chronic inflammatory rheumatic diseases that primarily include ankylosing spondylitis, reactive arthritis, and the arthritis associated with psoriasis and inflammatory bowel diseases...
  33. pmc The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study
    Jennifer A Curry
    Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    BMC Infect Dis 10:266. 2010
    b>Reactive arthritis (ReA) is a recognized sequela of infectious gastroenteritis (IGE)...
  34. ncbi Detection and frequency of Chlamydia trachomatis DNA in synovial samples from Tunisian patients with reactive arthritis and undifferentiated oligoarthritis
    Mariam Siala
    Laboratoire de recherche Micro organismes et Pathologie Humaine, EPS Habib Bourguiba, Sfax, Tunisia
    FEMS Immunol Med Microbiol 55:178-86. 2009
    ..Synovial samples from 20 of 34 (59%) patients [nine with reactive arthritis (ReA), seven with undifferentiated oligoarthritis (UOA), two with rheumatoid arthritis and two with ..
  35. ncbi Reactive arthritis associated with hidradenitis suppurativa
    April L Marquardt
    The Ohio State University Division of Immunology Rheumatology, William Davis Medical Research Center, Columbus, Ohio 43210 1228, USA
    J Natl Med Assoc 101:367-9. 2009
    This is a case report of a man with chronic hidradenitis suppurativa who developed reactive arthritis. He presented with swelling and pain in his larger joints, along with conjunctivitis involving his right eye...
  36. ncbi On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. Results and discussion of a questionnaire prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3
    J Braun
    Rheumatology Unit, Klinikum Benjamin Franklin, Free University, and Deutsches Rheumaforschungszentrum, Berlin, Germany
    J Rheumatol 27:2185-92. 2000
    There is no agreement on how to classify and diagnose reactive arthritis (ReA) and it is also unclear what kind of specific clinical and laboratory investigations are appropriate...
  37. ncbi Infliximab for reactive arthritis secondary to Chlamydia trachomatis infection
    Marcelo Derbli Schafranski
    Department of Internal Medicine and Rheumatology, Bom Jesus Hospital, Ponta Grossa, PR, Brazil
    Rheumatol Int 30:679-80. 2010
    b>Reactive arthritis is an autoimmune disease that develops 2-4 weeks after a triggering infection, resulting mainly in synovitis/enthesitis of the lower limbs, but with a wide array of possible extra-articular manifestations...
  38. ncbi Sialylation of Campylobacter jejuni lipo-oligosaccharides is associated with severe gastro-enteritis and reactive arthritis
    Ninell P Mortensen
    Unit of Gastrointestinal Infections, Statens Serum Institute, DK 2300 Copenhagen S, Denmark
    Microbes Infect 11:988-94. 2009
    ..We conclude that sialylation of C. jejuni LOS is not only a risk factor for development of post-infectious symptoms, but is also associated with increased severity of enteric disease...
  39. ncbi Sister chromatid exchanges and cell proliferative abilities in cultured peripheral blood lymphocytes of patients with rheumatoid and reactive arthritis
    S Jarmalaite
    Laboratory of Ecological Genetics, Vilnius University, Lithuania
    Clin Exp Rheumatol 24:677-82. 2006
    Analysis of cytogenetic alterations in peripheral blood lymphocytes (PBL) of patients with acute and chronic reactive arthritis (AcReA and ChrReA) and rheumatoid arthritis (RA).
  40. ncbi Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis
    Andrea Sinz
    Proteome Center Rostock, Medical Faculty, University of Rostock, Germany
    Electrophoresis 23:3445-56. 2002
    ..proteome analysis is used to study body fluids from patients suffering from rheumatoid arthritis (RA), reactive arthritis (reaA) or osteoarthritis (OA)...
  41. ncbi Pathogenesis of reactive arthritis
    D T Yu
    Department of Medicine, University of California, Los Angeles 90095 167022, USA
    Intern Med 38:97-101. 1999
    b>Reactive arthritis is a member of the spondyloarthropathy. Bacteria which cause reactive arthritis infect the mucosal surfaces...
  42. ncbi No increased risk of valvular heart disease in adult poststreptococcal reactive arthritis
    J M van Bemmel
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:987-93. 2009
    Poststreptococcal reactive arthritis (ReA) is a (poly)arthritis presenting after a Streptococcus group A infection...
  43. pmc Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis
    J J Haringman
    Division of Clinical Immunology and Rheumatology F4 218, Department of Internal Medicine, Academic Medical Centre University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 65:294-300. 2006
    ..Chemokine receptors and chemokines have a crucial role in leucocyte recruitment into inflamed tissue...
  44. ncbi Reactive arthritis
    M Leirisalo-Repo
    Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Rheumatol 34:251-9. 2005
    b>Reactive arthritis (ReA) was known as Reiter's disease or Fiessinger-Leroy disease for nearly 100 years. However, during the past 30 years the disease has been known as reactive arthritis, a member of the spondyloarthritis family...
  45. ncbi Reactive arthritis: a review
    Paul S Kim
    Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Adolesc Health 44:309-15. 2009
    This review article summarizes the available literature on adolescent reactive arthritis. A review of the pathophysiology, diagnosis, and treatment guidelines will be helpful to better diagnose and treat reactive arthritis.
  46. ncbi Elevation of D8/17-positive B lymphocytes in only a minority of Dutch patients with post-streptococcal reactive arthritis (PSRA): a pilot study
    T L T A Jansen
    Rheumatology (Oxford) 41:1202-3. 2002
  47. pmc Arthritis risk after acute bacterial gastroenteritis
    A X Garg
    London Kidney Research Unit, Division of Nephrology, London Health Sciences Centre, ON, Canada
    Rheumatology (Oxford) 47:200-4. 2008
    b>Reactive arthritis (ReA) may occur from bacterial gastroenteritis...
  48. ncbi Differentiation of post-streptococcal reactive arthritis from acute rheumatic fever
    Judith Barash
    Pediatric Day Care and Pediatric Rheumatology Service, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel
    J Pediatr 153:696-9. 2008
    ..and laboratory aspects of patients with acute rheumatic fever (ARF) and patients with post-streptococcal reactive arthritis (PSRA), to discern whether these are 2 separate entities or varying clinical manifestations of the same ..
  49. ncbi Ankylosing spondylitis, psoriatic arthritis, and reactive arthritis show increased bone resorption, but differ with regard to bone formation
    Johannes Grisar
    Department of Internal Medicine III, University of Vienna, Austria
    J Rheumatol 29:1430-6. 2002
    ..To test if markers of bone metabolism are altered in patients with seronegative spondyloarthropathies (SSpA)...
  50. ncbi Reactive arthritis or post-infectious arthritis?
    Timo Hannu
    Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Best Pract Res Clin Rheumatol 20:419-33. 2006
    The term 'reactive arthritis' was first used in 1969 to describe the development of sterile inflammatory arthritis as a sequel to remote infection, often in the gastrointestinal or urogenital tract...
  51. ncbi Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis
    Liora Harel
    Department of Pediatrics C, Schneider Children s Medical Center of Israel, Petach Tikvah, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Rheumatol Int 27:695-8. 2007
    ..aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 +/- 5...
  52. ncbi Potential triggering infections of reactive arthritis
    I Butrimiene
    Vilnius University, Insitutute of Experimental and Clinical Medicine, Vilnius, Lithuania
    Scand J Rheumatol 35:459-62. 2006
    The aim of the study was to investigate possible triggering infections causing reactive arthritis (ReA) of urogenital origin.
  53. ncbi Lack of association between the HLA-DRB1 locus and post-streptococcal reactive arthritis and acute rheumatic fever in Italian children
    Gabriele Simonini
    Rheumatology Unit, Department of Pediatrics, University of Florence, 50132 Firenze, Italy
    Semin Arthritis Rheum 34:553-8. 2004
    Post-streptococcal reactive arthritis (PSReA) may be a variant of acute rheumatic fever (ARF), but there still is debate on the relationship between the 2 entities...
  54. ncbi Reactive arthritis
    A Toivanen
    Departments of Medicine and Medical Microbiology, Turku University, Turku, Finland
    Isr Med Assoc J 3:681-5. 2001
    b>Reactive arthritis is a disease affecting mostly young adults. Owing to a greater general awareness the diagnosis has become more common during recent years...
  55. pmc A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis
    Ricardo G Espinola
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Pathol 165:969-76. 2004
    ..This study shows that monoclonal antibody C11C1 attenuates plasma kallikrein-kinin system activation, local and systemic inflammation, indicating therapeutic potential in reactive arthritis.
  56. ncbi Reactive arthritis following Streptococcus viridans urinary tract infection
    Yen Shou Chou
    Department of Ophthalmology, Tri Service General Hospital, Taipei 114, Taiwan
    Ocul Immunol Inflamm 18:52-3. 2010
    To report a case with reactive arthritis (ReA) following Streptococcus viridans genitourinary infection.
  57. ncbi Cutaneous vasculitis and reactive arthritis following respiratory infection due to Chlamydia pneumoniae: report of a case
    A Cascina
    Department of Haemathological, Pneumological and Cardiovascular Sciences and Respiratory Disease Clinic, University of Pavia, I R C C S Policlinico San Matteo, Pavia, Italy
    Clin Exp Rheumatol 20:845-7. 2002
    ..psittaci, the association of C. pneumoniae infection with immunological complications, such as reactive arthritis (ReA) or erythema nodosum (EN) has been rarely reported...
  58. pmc HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations
    Ines Colmegna
    Section of Rheumatology, Department of Medicine, LSU Health Science Center, New Orleans, Louisiana 70112, USA
    Clin Microbiol Rev 17:348-69. 2004
    Current evidence supports the concept that reactive arthritis (ReA) is an immune-mediated synovitis resulting from slow bacterial infections and showing intra-articular persistence of viable, non-culturable bacteria and/or immunogenetic ..
  59. ncbi Reactive arthritis: newer developments
    Diana Flores
    Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112 2822, USA
    Rheum Dis Clin North Am 29:37-59, vi. 2003
    b>Reactive arthritis (ReA) is characterized by an aseptic inflammatory articular involvement occurring in a genetically predisposed individual secondary to an infectious process localized outside the joint...
  60. pmc Three month treatment of reactive arthritis with azithromycin: a EULAR double blind, placebo controlled study
    T K Kvien
    Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
    Ann Rheum Dis 63:1113-9. 2004
    To determine the efficacy of weekly treatment with oral azithromycin for 13 weeks on the severity and resolution of reactive arthritis (ReA).
  61. ncbi Reactive arthritis associated with group C and group G beta-hemolytic streptococci
    T L Jansen
    Department of Rheumatology, Rijnstate Hospital, Arnhem, The Netherlands
    J Rheumatol 25:1126-30. 1998
    Group A beta-hemolytic streptococci (GAS) are known to be capable of evoking sterile arthritis. Reactive arthritis (ReA) has been reported sporadically following primary infection with group C and group G beta-hemolytic streptococci (GCS, ..
  62. ncbi Recent advances in reactive arthritis
    Ines Colmegna
    Curr Rheumatol Rep 7:201-7. 2005
    b>Reactive arthritis (ReA), one of the spondyloarthropathies, is an infectious related disease that occurs in a genetically predisposed individual, characterized by an immune-mediated synovitis with intra-articular persistence of viable ..
  63. ncbi Successful treatment of postvenereal reactive arthritis with synovectomy and 3 months' azithromycin
    Ljiljana Pavlica
    Department of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia and Montenegro
    J Clin Rheumatol 11:257-63. 2005
    The effects of antibiotic therapy on the course of postvenereal reactive arthritis have not yet been elucidated.
  64. ncbi [Quality of life and psychosocial adaptation in children and adolescents with juvenile idiopathic arthritis and reactive arthritis]
    E Müller-Godeffroy
    Universitatsklinikum Lubeck, Klinik fur Kinder und Jugendmedizin, Ratzburger Allee 160, 23538 Lubeck, Germany
    Z Rheumatol 64:177-87. 2005
    ..measure self-reported health related quality of life (HRQOL) and psychosocial adaptation in children and adolescents with juvenile idiopathic arthritis (JIA) and reactive arthritis and to determine factors associated with these outcomes.
  65. ncbi Pathogenesis of ankylosing spondylitis and reactive arthritis
    Tae Hwan Kim
    The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
    Curr Opin Rheumatol 17:400-5. 2005
    ..Peripheral joint synovitis can be a prominent feature as well. Reactive arthritis is a sterile synovitis arising after an extra-articular infection of enteric or urogenital tracts...
  66. ncbi Reactive arthritis: defined etiologies, emerging pathophysiology, and unresolved treatment
    John D Carter
    Division of Rheumatology, University of South Florida, 12901 Bruce B Downs Boulevard, MDC 81, Tampa, FL 33612, USA
    Infect Dis Clin North Am 20:827-47. 2006
    ..Despite this detailed knowledge, the proper treatment remains elusive. In the years to come it is possible that the specific treatment will be dictated by the triggering microbe...
  67. ncbi Differential expression of three Chlamydia trachomatis hsp60-encoding genes in active vs. persistent infections
    Herve C Gerard
    Department of Immunology and Microbiology, School of Medicine, Wayne State University, Gordon H Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Microb Pathog 36:35-9. 2004
    ..persistent infection. The results further suggest that the Ct604 gene product may function importantly during chlamydial persistence...
  68. ncbi Management of reactive arthritis
    Carlo Palazzi
    Unità Operativa Reumatologia, Casa di Cura, Villa Pini d Abruzzo, Via Dei Frentani, 228, Chieti, Italy
    Expert Opin Pharmacother 5:61-70. 2004
    b>Reactive arthritis (ReA) is an aseptic form of articular inflammation induced by infections mainly localised in the gastrointestinal (enteroarthritis) or urogenital (uroarthritis) tracts...
  69. ncbi Clostridium difficile-associated reactive arthritis in two children
    Helga A Löffler
    Department of Pediatric Rheumatology, Hopital Necker Enfants Malades, Universite Paris V, 149 rue de Sevres, 75743 Paris, France
    Joint Bone Spine 71:60-2. 2004
    In adults, reactive arthritis (ReA) following Clostridium difficile-enterocolitis has been documented. In children, only one case of C. difficile-associated ReA has been reported. We now describe two other cases of ReA associated with C...
  70. pmc Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis
    J van Holten
    Division of Clinical Immunology and Rheumatology F4 218, Academic Medical Centre, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Ann Rheum Dis 64:1780-2. 2005
    ..IFNbeta may have immunomodulatory effects in rheumatoid arthritis (RA) and its increased production in RA synovium may be a reactive attempt to inhibit inflammation...
  71. ncbi Early cytokine profiles in the joint define pathogen clearance and severity of arthritis in Chlamydia-induced arthritis in rats
    Robert D Inman
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 54:499-507. 2006
    ..We sought to investigate the host-microbe interactions that contribute to the severity of arthritis initiated by chlamydial infection...
  72. ncbi Is the enthesitis-related arthritis subtype of juvenile idiopathic arthritis a form of chronic reactive arthritis?
    N Saxena
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Rheumatology (Oxford) 45:1129-32. 2006
    Enteric organisms are known to trigger reactive arthritis. The enthesitis-related arthritis (ERA) form of juvenile idiopathic arthritis (JIA) clinically resembles reactive arthritis...
  73. ncbi Reactive arthritis
    Auli Toivanen
    Department of Medicine, Turku University, FIN 20520 Turku, Finland
    Best Pract Res Clin Rheumatol 18:689-703. 2004
    b>Reactive arthritis is an infectious disease which may be initiated by several microbes in genetically susceptible hosts. The best known predisposing genetic factor is HLA-B27, but the mechanisms behind its action are still elusive...
  74. pmc Reactive arthritis attributable to Shigella infection: a clinical and epidemiological nationwide study
    T Hannu
    Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, PO Box 263, FIN 00029 HUCH, Finland
    Ann Rheum Dis 64:594-8. 2005
    To study the incidence and clinical picture of Shigella associated reactive arthritis (ReA) and the arthritogenicity of various Shigella species in the population.
  75. ncbi Arthritis associated with Strongyloides stercoralis infection in HLA B-27-positive African
    Joachim Richter
    Tropenmedizinische Ambulanz, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat, Dusseldorf, Germany
    Parasitol Res 99:706-7. 2006
    ..2 mg kg(-1) day(-1) for 2 days and non-steroidal anti-inflammatorials. Reactive arthritis is known to be caused by various bacterial agents...
  76. ncbi Reactive arthritis
    Danielle Lauren Petersel
    Division of Rheumatology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, MEB484, PO Box 19, New Brunswick, NJ 08903 0019, USA
    Infect Dis Clin North Am 19:863-83. 2005
    ..Diagnosis usually can be made by clinical examination and history. The current standard therapy is NSAIDs and physiotherapy, but molecular biologic treatment may ultimately become the mainstay in recalcitrant and severe ReA...
  77. ncbi Poststreptococcal reactive arthritis: what is it and how do we know?
    S L Mackie
    Department of Rheumatology, Northwick Park Hospital, Harrow, Middlesex, UK
    Rheumatology (Oxford) 43:949-54. 2004
    To find out whether poststreptococcal reactive arthritis (PSRA) is a discrete, homogeneous clinical syndrome.
  78. ncbi Circulating soluble interleukin-2 receptor level predicts remission in very early reactive arthritis
    A Kuuliala
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Scand J Rheumatol 34:372-5. 2005
    To assess the predictive value of serum soluble interleukin-2 receptor (sIL-2R) levels in patients with acute reactive arthritis (ReA).
  79. pmc Persistent infection of Chlamydia in reactive arthritis
    M Rihl
    Ann Rheum Dis 65:281-4. 2006
  80. pmc When is arthritis reactive?
    S S Hamdulay
    Department of Rheumatology, Northwick Park Hospital, Harrow, Middlesex, UK
    Postgrad Med J 82:446-53. 2006
    b>Reactive arthritis is an important cause of lower limb oligoarthritis, mainly in young adults...
  81. pmc Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis
    Martin Skoumal
    Arthritis Res Ther 6:73-4. 2004
  82. pmc Reactive arthritis after an outbreak of Yersinia pseudotuberculosis serotype O:3 infection
    T Hannu
    Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland
    Ann Rheum Dis 62:866-9. 2003
    To determine the occurrence and clinical characteristics of reactive arthritis (ReA) after an outbreak of Yersinia pseudotuberculosis serotype O:3 infection.
  83. ncbi Microbial factors in spondyloarthropathies: insights from population studies
    Marjatta Leirisalo-Repo
    Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Curr Opin Rheumatol 15:408-12. 2003
    Infections and genetics play a role in the development of reactive arthritis. The clinical manifestations and severity of the features depend on the triggering infections and the epidemiologic setting...
  84. ncbi Importance of species-specific antigens in the serodiagnosis of Chlamydia trachomatis reactive arthritis
    S Bas
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Rheumatology (Oxford) 41:1017-20. 2002
    To determine the most sensitive and specific method of anti-Chlamydia antibody measurement for the serodiagnosis of Chlamydia trachomatis reactive arthritis.
  85. ncbi Chromosomal DNA from a variety of bacterial species is present in synovial tissue from patients with various forms of arthritis
    H C Gerard
    Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Arthritis Rheum 44:1689-97. 2001
    ..have reported the presence of Chlamydia and other bacterial species in joint specimens from patients with reactive arthritis (ReA)...
  86. ncbi Clostridium difficile: an under-recognized cause of reactive arthritis?
    Julius Birnbaum
    Johns Hopkins University School of Medicine, Mason F Lord Building, Baltimore, MD 21224, USA
    Clin Rheumatol 27:253-5. 2008
    b>Reactive arthritis usually presents as a sterile, inflammatory, asymmetric oligoarthritis, affecting large lower extremity joints...
  87. ncbi Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy
    Rajeev Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 34:2285-90. 2007
    Data on synovial fluid (SF) cytokine concentrations in patients with reactive arthritis (ReA) or undifferentiated spondyloarthropathy (uSpA) are limited and contradictory...
  88. ncbi Toll-like receptor 2 variants are associated with acute reactive arthritis
    Florence W L Tsui
    Toronto Western Research Institute, University Health Network, and University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 58:3436-8. 2008
    ..The objective of this study was to identify genetic variants that might predispose infected individuals to develop articular and/or extraarticular sequelae after Salmonella enteritidis infection...
  89. pmc Dietary glycine prevents peptidoglycan polysaccharide-induced reactive arthritis in the rat: role for glycine-gated chloride channel
    X Li
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina at Chapel Hill, North Carolina 27599-7365, USA
    Infect Immun 69:5883-91. 2001
    ..This work supports the hypothesis that glycine prevents reactive arthritis by blunting cytokine release from macrophages by increasing chloride influx via a glycine-gated chloride ..
  90. ncbi Reactive arthritis and Reiter's syndrome following an outbreak of gastroenteritis caused by Salmonella enteritidis
    M S Dworkin
    Centers for Disease Control and Prevention, Epidemiology Program Office, Division of Applied Public Health Training, Epidemic Intelligence Service, Atlanta, GA, USA
    Clin Infect Dis 33:1010-4. 2001
    b>Reactive arthritis and Reiter's syndrome have been reported following gastroenteritis...
  91. ncbi Detection of bacterial DNA in Latin American patients with reactive arthritis by polymerase chain reaction and sequencing analysis
    Raquel Cuchacovich
    Department of Medicine, LSU Health Science, Center, New Orleans, Louisiana 70112, USA
    J Rheumatol 29:1426-9. 2002
    Bacteria and/or their antigens are thought to play a role in the pathogenesis of reactive arthritis (ReA)...
  92. pmc Anticardiolipin antibodies in patients with post-streptococcal reactive arthritis
    N Tamura
    Ann Rheum Dis 61:374. 2002
  93. pmc Reactive arthritis following an outbreak of Salmonella typhimurium phage type 193 infection
    T Hannu
    Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland
    Ann Rheum Dis 61:264-6. 2002
    To determine the occurrence and the clinical picture of reactive arthritis (ReA) following an outbreak of Salmonella typhimurium.
  94. ncbi Symptomatic acute reactive arthritis after an outbreak of salmonella
    Sherry Rohekar
    Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 35:1599-602. 2008
    ..Salmonella is a known trigger of reactive arthritis (ReA)...
  95. ncbi Frequency of recent parvovirus infection in patients examined for acute reactive arthritis. A study with combinatorial parvovirus serodiagnostics
    T Hannu
    Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital HUCH, Finland
    Clin Exp Rheumatol 25:297-300. 2007
    To determine the causative role of human parvovirus B19 as a preceding infection in patients examined for acute reactive arthritis (ReA).
  96. pmc Annual incidence of inflammatory joint diseases in a population based study in southern Sweden
    M K Söderlin
    Department of Internal Medicine, Vaxjo Central Hospital, 351 85 Växjö, Sweden
    Ann Rheum Dis 61:911-5. 2002
    ..To estimate the annual incidence of inflammatory joint diseases in a population based prospective referral study in an adult population in Kronoberg County in southern Sweden...
  97. ncbi Infection and musculoskeletal conditions: Reactive arthritis
    Markus Rihl
    Division of Rheumatology, Hannover Medical School MHH, Carl Neuberg Str 1, 30625 Hannover, Germany
    Best Pract Res Clin Rheumatol 20:1119-37. 2006
    b>Reactive arthritis (ReA) has been recognized as a clinical disease entity for nearly 100 years. The prevalence is estimated to be 30-40/100,000 adults. The HLA-B27-associated form is part of the spondyloarthritis concept...
  98. pmc Synoviocyte-packaged Chlamydia trachomatis induces a chronic aseptic arthritis
    R D Inman
    The Toronto Hospital, University of Toronto, Toronto, ON M5T 2S8, Canada
    J Clin Invest 102:1776-82. 1998
    The basic mechanisms underlying reactive arthritis and specifically the joint injury that follows intra-articular Chlamydia trachomatis infection have not been defined...
  99. ncbi Arthritis associated with enteric infection
    J S Hill Gaston
    Department of Medicine, Box 157, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Rheumatol 17:219-39. 2003
    b>Reactive arthritis is classically seen following infection with enteric pathogens such as Yersinia, Salmonella, Campylobacter and Shigella...
  100. pmc Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial
    J D Carter
    Department of Internal Medicine, Division of Rheumatology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Arthritis Rheum 62:1298-307. 2010
    Chlamydia trachomatis and Chlamydophila (Chlamydia) pneumoniae are known triggers of reactive arthritis (ReA) and exist in a persistent metabolically active infection state in the synovium, suggesting that they may be susceptible to ..
  101. ncbi Determinants of synoviocyte clearance of arthritogenic bacteria
    Robert D Inman
    Arthritis Center of Excellence, Toronto Western Hospital Research Institute, Ontario, Canada
    J Rheumatol 30:1291-7. 2003
    Persistence of intracellular organisms may play a critical role in the initiation and perpetuation of synovitis in reactive arthritis (ReA). We investigated factors that may influence local clearance of arthritogenic pathogens in ReA.

Research Grants26

  1. A Low Cost Microarray for Population-Scale AIDS Risk Analysis: The AIDS Chip
    Michael E Hogan; Fiscal Year: 2010
    ..role for HLA-B in personalized medicine, for AIDS and for conditions such as Stevens-Johnson syndrome &reactive arthritis (plus many others that are more speculative at present), we argue that the time is right to develop a simple,..
  2. Analysis of Genetic Susceptibility to Anterior Uveitis
    TAMMY MARTIN; Fiscal Year: 2009
    ..that is associated with HLA-B27 and the spondyloarthritic diseases, such as ankylosing spondylitis and reactive arthritis. However, this form of uveitis may also occur in patients with no other systemic inflammatory diseases...
  3. IMMUNOPATHOLOGY OF CHLAMYDIA--INDUCED REACTIVE ARTHRITIS
    Roger Rank; Fiscal Year: 1991
    b>Reactive arthritis has been found to result from gastrointestinal infections with Yersinia enterocolitica, Salmonella, Shigella, and Campylobacter and from genital tract infections with Chlamydia trachomatis...
  4. ANTICHLAMYDIAL PROTECTION BY MOLECULAR MIMCRY
    JUDITH WHITTUM HUDSON; Fiscal Year: 2002
    ..trachoma) and are also associated with arthritis in a significant number of patients with Reiter's syndrome/Reactive arthritis. The public health costs of chlamydial infections and their sequelae are enormous...
  5. CONFERENCE ON HLA-B27 RELATED DISORDERS
    Peter Lipsky; Fiscal Year: 1991
    ..mimicry; 6) Epidemiology of B27 associated conditions; and 7) Clinical aspects of ankylosing spondylitis and reactive arthritis. This will be the first international symposium devoted to the topic that will bring together investigators ..
  6. Pathogenic mechanisms in chlamydial reactive arthritis
    JUDITH WHITTUM HUDSON; Fiscal Year: 2005
    b>Reactive arthritis (ReA) is a chronic disease characterized by periods of flare alternating with periods of less active inflammation. One criterion of disease classification is a history of prior sexually transmitted or GI infection...
  7. IMMUNOLOGIC DISEASES--CELLULAR AND MOLECULAR MECHANISMS
    John Leddy; Fiscal Year: 1992
    ..These investigations receive impetus from an interest in the potential role of immunologically activated platelets and endothelial cells in immune complex and vaso- obstructive diseases...
  8. GRAM NEGATIVE ENTERIC PATHOGENS AND AUTOIMMUNITY
    Mark Soloski; Fiscal Year: 2001
    ..large patient cohort seen by the Division of Rheumatology at our institution and includes individuals with Reactive Arthritis, Reiter's Disease and Ankylosing Spondylitis...
  9. ROLE OF APOE IN THE PATHOGENESIS OF CHLAMYDIA PNEUMONIAE
    HERVE GERARD; Fiscal Year: 2002
    DESCRIPTION (Taken from the application): An infectious etiology for reactive arthritis (ReA) has long been suspected since this diseases often follow primary infections of the gastrointestinal, urogenital, and respiratory tracts...
  10. Study of Persistent Infection in SSc Skin and Vessels
    Maureen Mayes; Fiscal Year: 2003
    ..resulting in chronic inflammatory autoimmune diseases including Lyme disease (Borrelia burgdorferii), and reactive arthritis (ReA), an inflammatory joint disease associated with prior infection by a number of specific bacterial ..
  11. FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITIS
    John Reveille; Fiscal Year: 2003
    ..abstract_text> ..
  12. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..The family of diseases encompassed by Spondyloarthritis includes: 1) ankylosing spondylitis; 2) reactive arthritis known previously as Reiter's syndrome; 3) psoriatic arthritis and/or spondylitis, 4) enteropathic ..
  13. IMMUNOLOGY/MOLECULAR BIOLOGY TRAINING IN OPHTHALMOLOGY
    James Rosenbaum; Fiscal Year: 2007
    ..The quality of the institution, the talents of the specific faculty, the abilities of the applicant pool, and the proven success of the program areadditional strengths of this application. ..
  14. FOUR DIMENSIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James T Rosenbaum; Fiscal Year: 2010
    ..These studies should result in a fundamental improvement in the understanding of how T cells behave within a site of inflammation. ..
  15. 13th International Campylobacter/Helicobacter workshop
    Irving Nachamkin; Fiscal Year: 2005
    ..antimicrobial therapy, new and emerging pathogens, and immune sequelae such as Guillain-Barre syndrome and reactive arthritis. These international workshops provide the ideal opportunity for clinicians and scientists from a variety of ..
  16. Endotoxin-induced Uveitis Revisited
    James T Rosenbaum; Fiscal Year: 2010
    ..Future studies can buil d on these observations to test anti-inflammtory molecules induced by endotoxin as these molecules are potentially useful in the treatment of uveitis and other inflammations. ..
  17. UVEITIS GENE-EXPRESSION PROFILING
    James Rosenbaum; Fiscal Year: 2008
    ..The creation of a gene expression data base for patients with uveitis has the potential to clarify the pathogenesis of disease, establish new diagnostic tools, and provide a means for predicting prognosis. ..
  18. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2008
    ..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
  19. 14th International CHRO Workshop
    Irving Nachamkin; Fiscal Year: 2007
    ..therapy, new and emerging pathogens, and immune[unreadable] sequelae such as Guillain-Barre syndrome and reactive arthritis. These international workshops[unreadable] provide the ideal opportunity for clinicians and scientists from ..
  20. Reiter's syndrome mechanism of chlamydial pathogenesis
    Alan Hudson; Fiscal Year: 2008
    Genital infection with the bacterial pathogen Chlamydia trachomatis is associated with development of reactive arthritis (ReA)...
  21. Combination Antibotics as a Treatment for Chlamydia-Induced Reactive Arthritis
    John Carter; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Reactive Arthritis (ReA) is an inflammatory arthritis that arises after certain genitourinary and gastrointestinal infections. Chlamydia trachomatis (Ct) is a known trigger for ReA...
  22. Glycosylation of Campylobacter flagella
    Patricia Guerry; Fiscal Year: 2007
    ..The biological role of flagella glycosylation will be studied by examining a series of mutants in in vitro and in vivo assays of virulence. ..
  23. Anterior Uveal Dendritic Cells
    James Rosenbaum; Fiscal Year: 2004
    ..These studies will clarify the function of the immune system within the eye and may suggest novel therapeutic approaches in the treatment of uveitis. ..
  24. CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
    Alan Hudson; Fiscal Year: 2002
    ..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..