osteomyelitis

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Articles from Journal RESEARCH

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  1. ncbi CT and MRI in tuberculous sternal osteomyelitis: a case report
    Cetin Atasoy
    Department of Radiology, Ibn i Sina Hospital, School of Medicine, Ankara University, 06100, Ankara, Turkey
    Clin Imaging 26:112-5. 2002
  2. ncbi Hematogenous vertebral osteomyelitis due to Staphylococcus aureus in the adult: clinical features and therapeutic outcomes
    David H Priest
    Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    South Med J 98:854-62. 2005
  3. ncbi Intracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitis
    J Kent Ellington
    Department of Orthopaedic Surgery, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, North Carolina 28223, USA
    J Orthop Res 24:87-93. 2006
  4. ncbi Osteomyelitis
    Daniel P Lew
    Services of Infectious Diseases and Medicine 2, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    Lancet 364:369-79. 2004
  5. pmc Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis
    Amro Widaa
    Microbial Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e40586. 2012
  6. pmc Panton-valentine leukocidin enhances the severity of community-associated methicillin-resistant Staphylococcus aureus rabbit osteomyelitis
    Anne Claude Cremieux
    Département de médecine aiguë, Hôpital Universitaire Raymond Poincaré, Assistance Publique Hopitaux de Paris, Garches, France
    PLoS ONE 4:e7204. 2009
  7. ncbi Characterization of a rabbit model of staphylococcal osteomyelitis
    M S Smeltzer
    Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Orthop Res 15:414-21. 1997
  8. pmc Genome sequences of four divergent multidrug-resistant Acinetobacter baumannii strains isolated from patients with sepsis or osteomyelitis
    Daniel V Zurawski
    Walter Reed Army Institute of Research WRAIR, Department of Wound Infections, Silver Spring, Maryland, USA
    J Bacteriol 194:1619-20. 2012
  9. ncbi Emerging pathogenetic mechanisms of the implant-related osteomyelitis by Staphylococcus aureus
    Lucio Montanaro
    Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Artif Organs 34:781-8. 2011
  10. pmc Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis
    Francisco M Marty
    Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
    J Clin Microbiol 44:595-7. 2006

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Articles from Journal RESEARCH1

Publications282 found, 100 shown here

  1. ncbi CT and MRI in tuberculous sternal osteomyelitis: a case report
    Cetin Atasoy
    Department of Radiology, Ibn i Sina Hospital, School of Medicine, Ankara University, 06100, Ankara, Turkey
    Clin Imaging 26:112-5. 2002
    ..Treatment included both surgical intervention and medical therapy...
  2. ncbi Hematogenous vertebral osteomyelitis due to Staphylococcus aureus in the adult: clinical features and therapeutic outcomes
    David H Priest
    Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    South Med J 98:854-62. 2005
    Staphylococcus aureus is the most common cause of hematogenous vertebral osteomyelitis in adults...
  3. ncbi Intracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitis
    J Kent Ellington
    Department of Orthopaedic Surgery, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, North Carolina 28223, USA
    J Orthop Res 24:87-93. 2006
    Staphylococcus aureus is responsible for 80% of human osteomyelitis. It can invade and persist within osteoblasts. Antibiotic resistant strains of S. aureus make successful treatment of osteomyelitis difficult...
  4. ncbi Osteomyelitis
    Daniel P Lew
    Services of Infectious Diseases and Medicine 2, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    Lancet 364:369-79. 2004
    ..The various types of osteomyelitis require differing medical and surgical therapeutic strategies...
  5. pmc Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis
    Amro Widaa
    Microbial Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e40586. 2012
    Staphylococcus aureus is the most frequent causative organism of osteomyelitis. It is characterised by widespread bone loss and bone destruction. Previously we demonstrated that S...
  6. pmc Panton-valentine leukocidin enhances the severity of community-associated methicillin-resistant Staphylococcus aureus rabbit osteomyelitis
    Anne Claude Cremieux
    Département de médecine aiguë, Hôpital Universitaire Raymond Poincaré, Assistance Publique Hopitaux de Paris, Garches, France
    PLoS ONE 4:e7204. 2009
    ..in the United States, and the concomitant increase in severe invasive staphylococcal infections, including osteomyelitis, in healthy children, has led to renewed interest in Panton-Valentine leukocidin (PVL)...
  7. ncbi Characterization of a rabbit model of staphylococcal osteomyelitis
    M S Smeltzer
    Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Orthop Res 15:414-21. 1997
    We previously described a rabbit osteomyelitis model that involved the direct introduction of Staphylococcus aureus into devascularized bone...
  8. pmc Genome sequences of four divergent multidrug-resistant Acinetobacter baumannii strains isolated from patients with sepsis or osteomyelitis
    Daniel V Zurawski
    Walter Reed Army Institute of Research WRAIR, Department of Wound Infections, Silver Spring, Maryland, USA
    J Bacteriol 194:1619-20. 2012
    ..Four A. baumannii strains from the Walter Reed Army Medical Center (WRAMC) isolated between 2008 and 2009 were sequenced, representing diverse, multidrug-resistant isolates from osteomyelitis or septic patients.
  9. ncbi Emerging pathogenetic mechanisms of the implant-related osteomyelitis by Staphylococcus aureus
    Lucio Montanaro
    Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Artif Organs 34:781-8. 2011
    Implant-related osteomyelitis is a severe and deep infection of bone that arises and develops all around an implant. Staphylococcus aureus is the first cause of osteomyelitis, whether implant-related or not...
  10. pmc Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis
    Francisco M Marty
    Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
    J Clin Microbiol 44:595-7. 2006
    ..aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-..
  11. ncbi Osteomyelitis in military personnel wounded in Iraq and Afghanistan
    Heather C Yun
    Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S163-8; discussion S168. 2008
    ..We describe demographics and microbiology of OIF/OEF casualties with primary and recurrent osteomyelitis.
  12. ncbi Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: a hospital-based cohort study in Japan
    Toru Yamazaki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54, Shogoin Kawahara cho, Kyoto 606 8507, Japan
    Bone 51:882-7. 2012
    ..However, several studies have reported osteonecrosis of the jaw (ONJ), also known as osteomyelitis of the jaw (OMJ), as a side effect of these drugs...
  13. ncbi Osteomyelitis and the role of biofilms in chronic infection
    Rebecca A Brady
    Department of Microbiology and Immunology, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201, USA
    FEMS Immunol Med Microbiol 52:13-22. 2008
    ....
  14. ncbi Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis
    Otto S Kluin
    Department of Biomedical Engineering, W J Kolff Institute, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Expert Opin Drug Deliv 10:341-51. 2013
    Chronic osteomyelitis, or bone infection, is a major worldwide cause of morbidity and mortality, as it is exceptionally hard to treat due to patient and pathogen-associated factors...
  15. ncbi Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres
    Erdal Cevher
    Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Turkey
    Int J Pharm 317:127-35. 2006
    ..microspheres were implanted to proximal tibia of rats with methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. Intramuscular (IM) injection of VANCO for 21 days was applied to another group for comparison...
  16. pmc Efficacy of anti-IL-1 treatment in Majeed syndrome
    Troels Herlin
    Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
    Ann Rheum Dis 72:410-3. 2013
    Majeed syndrome is an autosomal recessive disorder characterised by the triad of chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anaemia and a neutrophilic dermatosis that is caused by mutations in LPIN2...
  17. pmc Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
    Philippe Hernigou
    Department of Orthopaedic Surgery, University Paris XII, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Clin Orthop Relat Res 468:1676-81. 2010
    Septic arthritis is a known complication of sickle cell disease (SCD) in children, and the association with osteomyelitis and osteonecrosis has been described. However, it is unclear whether this association applies to adults.
  18. ncbi The impact of the current epidemiology of pediatric musculoskeletal infection on evaluation and treatment guidelines
    Omar A Gafur
    University of Texas Southwestern, Dallas, TX, USA
    J Pediatr Orthop 28:777-85. 2008
    ....
  19. ncbi Single-stage autogenous bone grafting and internal fixation in the surgical management of pyogenic discitis and vertebral osteomyelitis
    G J Przybylski
    Department of Neurosurgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Neurosurg 94:1-7. 2001
    ..Comparatively fewer patients with pyogenic discitis and vertebral osteomyelitis (PDVO) have undergone single-stage debridement, arthrodesis, and internal fixation...
  20. ncbi Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofa
    Toshiyuki Yoneda
    Department of Biochemistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Bone Miner Metab 28:365-83. 2010
    ....
  21. pmc Interaction of staphylococci with bone
    John A Wright
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Int J Med Microbiol 300:193-204. 2010
    ....
  22. ncbi Mycobacterium ulcerans disease (Buruli ulcer) in a rural hospital in Bas-Congo, Democratic Republic of Congo, 2002-2004
    Delphin M Phanzu
    Institut Medical Evangelique, Kimpese Hospital, Kimpese, Bas Congo, Democratic Republic of Congo
    Am J Trop Med Hyg 75:311-4. 2006
    ..Extensive clinical data, treatment outcomes, and socioeconomic correlations are summarized. Osteomyelitis was an important complication...
  23. ncbi (68)Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones
    Petteri Lankinen
    Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 35:352-64. 2008
    ....
  24. pmc Intermediate vancomycin susceptibility in a community-associated MRSA clone
    Christopher J Graber
    Division of Infectious Diseases, University of California, San Francisco General Hospital, 94110, USA
    Emerg Infect Dis 13:491-3. 2007
    ..The strain was isolated from the bone of a 56-year-old man with lumbar osteomyelitis after a 6-week treatment course of vancomycin for catheter-associated septic thrombophlebitis.
  25. ncbi Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblasts
    Amy B Young
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Bone 48:857-63. 2011
    ..While inflammatory damage during conditions such as osteomyelitis is associated with increased formation and activity of bone-resorbing osteoclasts, it is likely that bone loss ..
  26. ncbi Delayed primary versus late secondary wound closure in the treatment of postsurgical sternum osteomyelitis
    Denis A Berdajs
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Interact Cardiovasc Thorac Surg 12:914-8. 2011
    Sternal osteomyelitis and poststernotomy mediastinitis is a severe and life-threatening complication after the cardiac surgery. The incidence ranges up to 3% with a mortality rate up to 29%...
  27. ncbi Efficacy of antibiotics-loaded interpenetrating network (IPNs) hydrogel based on poly(acrylic acid) and gelatin for treatment of experimental osteomyelitis: in vivo study
    Mohammad Changez
    Centre for Biomedical Engineering, IIT Delhi, Hauz Khas, New Delhi 110016, India
    Biomaterials 26:2095-104. 2005
    ..and drug-loaded device of AxGx (acrylic acid:gelatin: 1:1 w/w) were employed for the treatment of experimental osteomyelitis in rabbit. Rabbits were categorized into four groups...
  28. ncbi Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: prospective, randomized trial on 131 culture-positive cases
    Heikki Peltola
    Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland
    Pediatr Infect Dis J 29:1123-8. 2010
    Considerable uncertainty exists on the optimal duration of antimicrobials for acute hematogenous osteomyelitis (AHOM) in children...
  29. ncbi Radiolucent inflammatory jaw lesions: a twenty-year analysis
    K Becconsall-Ryan
    Department of Oral Diagnostic and Surgical Sciences, University of Otago School of Dentistry, Dunedin, New Zealand
    Int Endod J 43:859-65. 2010
    ..To determine the range and demographic and clinical features of radiolucent inflammatory jaw lesions...
  30. ncbi Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Immunol Res 30:291-308. 2004
    ..there is growing realization that osteoblasts have an additional function during bone diseases, such as osteomyelitis. Based on our recent studies, we propose a novel role for osteoblasts during bacterial infections of bone, ..
  31. ncbi Novel borate glass/chitosan composite as a delivery vehicle for teicoplanin in the treatment of chronic osteomyelitis
    Wei Tao Jia
    Department of Orthopedic Surgery, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
    Acta Biomater 6:812-9. 2010
    ..were investigated in vitro and in vivo as a new delivery system for teicoplanin in the treatment of chronic osteomyelitis induced by methicillin-resistant Staphylococcus aureus (MRSA)...
  32. ncbi Improvement of gentamicin poly(D,L-lactic-co-glycolic acid) microspheres for treatment of osteomyelitis induced by orthopedic procedures
    Maria Rosa Virto
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University, Madrid 28040, Spain
    Biomaterials 28:877-85. 2007
    ..Two models, one of them including an autocatalytic process, were finally proposed to contribute to understand the mass transport mechanism involved in drug release from these microspheres...
  33. ncbi Evaluation of an in situ setting injectable calcium phosphate as a new carrier material for gentamicin in the treatment of chronic osteomyelitis: studies in vitro and in vivo
    U Joosten
    Department of Trauma and Hand Surgery, Westfalian Wilhelms University of Munster, Muenster, Germany
    Biomaterials 25:4287-95. 2004
    ..of hydroxyapatite cement (HAC) as a new carrier system in the treatment of chronic, posttraumatic osteomyelitis. In the in vitro study, release of gentamicin from standard cylinders of HAC were measured by agar diffusion ..
  34. pmc The epidemiology of hematogenous vertebral osteomyelitis: a cohort study in a tertiary care hospital
    Kavita P Bhavan
    Division of Infectious Diseases, Washington University School of Medicine, St, Louis, MO, USA
    BMC Infect Dis 10:158. 2010
    Vertebral osteomyelitis is a common manifestation of osteomyelitis in adults and associated with considerable morbidity. Limited data exist regarding hematogenous vertebral osteomyelitis...
  35. pmc Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis
    Tania Claro
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 6:e18748. 2011
    b>Osteomyelitis is a debilitating infectious disease of the bone. It is predominantly caused by S. aureus and is associated with significant morbidity and mortality...
  36. pmc Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity
    Dan Li
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 26:96-105. 2008
    Although osteomyelitis (OM) remains a serious problem in orthopedics, progress has been limited by the absence of an in vivo model that can quantify the bacterial load, metabolic activity of the bacteria over time, immunity, and ..
  37. ncbi Osteomyelitis and septic arthritis in children: current concepts
    Emily R Dodwell
    Hospital for Special Surgery, New York, New York 10021, USA
    Curr Opin Pediatr 25:58-63. 2013
    The cause, epidemiology, diagnosis, and treatment of osteoarticular infections have changed considerably in recent years. The current review includes the most up to date literature on pediatric septic arthritis and osteomyelitis.
  38. ncbi Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis
    Carla Renata Arciola
    Research Unit on Implant Infections, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 35:713-26. 2012
    ..Implant-associated osteomyelitis is a deep infection of bone around the implant...
  39. pmc Ceftobiprole efficacy in vitro against Panton-Valentine leukocidin production and in vivo against community-associated methicillin-resistant Staphylococcus aureus osteomyelitis in rabbits
    Azzam Saleh-Mghir
    Département de Médecine Aiguë Spécialisée, Hôpital Universitaire Raymond Poincaré, Assistance Publique Hopitaux de Paris, France
    Antimicrob Agents Chemother 56:6291-7. 2012
    Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) can cause osteomyelitis with severe sepsis and/or local complications in which a Panton-Valentine leukocidin (PVL) role is suspected...
  40. ncbi Surgical amputation of a digit and vacuum-assisted-closure (V.A.C.) management in a case of osteomyelitis and wound care in an eastern black rhinoceros (Diceros bicornis michaeli)
    Tara M Harrison
    Potter Park Zoo, 1301 South Pennsylvania, Lansing, Michigan 48912, USA
    J Zoo Wildl Med 42:317-21. 2011
    A 14-yr-old female eastern black rhinoceros (Diceros bicornis michaeli) presented with progressive suppurative osteomyelitis in her left hind lateral toe. beta-Hemolytic Streptococcus sp. was isolated...
  41. pmc Randomized controlled trial of the safety and efficacy of Daptomycin versus standard-of-care therapy for management of patients with osteomyelitis associated with prosthetic devices undergoing two-stage revision arthroplasty
    Ivor Byren
    Nuffield Orthopaedic Centre, Oxford, United Kingdom
    Antimicrob Agents Chemother 56:5626-32. 2012
    ..In conclusion, daptomycin at 6 and 8 mg/kg given for up to 6 weeks was safe and appeared to be effective in managing staphylococcal PJI using a 2-stage revision arthroplasty technique in a total of 49 patients...
  42. ncbi A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis
    Sarah A Horst
    Infection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Am J Pathol 181:1206-14. 2012
    b>Osteomyelitis is a serious bone infection typically caused by Staphylococcus aureus. The pathogenesis of osteomyelitis remains poorly understood, mainly for lack of experimental models that closely mimic human disease...
  43. ncbi Anti-infection tissue engineering construct treating osteomyelitis in rabbit tibia
    Junchao Xing
    Department of Orthopaedics, Southwest Hospital, Chongqing, China
    Tissue Eng Part A 19:255-63. 2013
    ..a fibrin gel scaffold and vancomycin alginate beads (Vanco-AB) to form composites, in the treatment of chronic osteomyelitis with bone defect in rabbit tibia. The infected bone defect model of rabbit tibia was established...
  44. ncbi Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature
    J Dartnell
    Maidstone and Tunbridge Wells NHS Trust, Pembury, UK
    J Bone Joint Surg Br 94:584-95. 2012
    A delay in the diagnosis of paediatric acute and subacute haematogenous osteomyelitis can lead to potentially devastating morbidity...
  45. ncbi Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle
    Francesco Bertoldo
    Internal Medicine, Bone Mineral Metabolism Unit, University of Verona, Verona, Italy
    Nat Clin Pract Oncol 4:711-21. 2007
    ..of decreased production of cytokines derived from the bone matrix, and the bone is exposed to the risk of osteomyelitis and necrosis...
  46. pmc A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: description of two unrelated cases from Brazil
    Adriana A Jesus
    Universidade de Sao Paulo, Sao Paulo, Brazil
    Arthritis Rheum 63:4007-17. 2011
    ..This study was undertaken to present the characteristics of the DIRA syndrome in 2 cases from Brazil, and describe a novel mutation in IL1RN...
  47. ncbi Treatment of chronic femoral osteomyelitis with platelet-rich plasma (PRP): a case report
    Ting Yuan
    Orthopaedic Department, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai, China
    Transfus Apher Sci 38:167-73. 2008
    Chronic osteomyelitis is a serious problem in developing countries...
  48. ncbi A simple infection model using pre-colonized implants to reproduce rat chronic Staphylococcus aureus osteomyelitis and study antibiotic treatment
    M Monzon
    CSIC SIA, Department of Animal Health, Zaragoza, Spain
    J Orthop Res 19:820-6. 2001
    ..In this work, a novel chronic osteomyelitis infection model was developed in rats in the absence of bacterial suspension, requiring the use of only 10(6) ..
  49. ncbi Pneumococcal vertebral osteomyelitis: a unique case with atypical clinical course
    A Poyanli
    Department of Orthopaedics and Traumatology, Göztepe SSK Educational Hospital, Kadikoy, Istanbul, Turkey
    Spine (Phila Pa 1976) 26:2397-9. 2001
    ..A case report...
  50. ncbi Antibiotic treatment for acute haematogenous osteomyelitis of childhood: moving towards shorter courses and oral administration
    M Paakkonen
    Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland
    Int J Antimicrob Agents 38:273-80. 2011
    Acute haematogenous osteomyelitis (AHOM) of childhood usually affects the long bones of the lower limbs...
  51. pmc A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis
    James E Cassat
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Host Microbe 13:759-72. 2013
    b>Osteomyelitis is a common manifestation of invasive Staphylococcus aureus infection. Pathogen-induced bone destruction limits antimicrobial penetration to the infectious focus and compromises treatment of osteomyelitis...
  52. ncbi Role of hyperbaric oxygen therapy in the treatment of bacterial spinal osteomyelitis
    Raheel Ahmed
    The University of Iowa, Department of Neurosurgery, Iowa City, Iowa, USA
    J Neurosurg Spine 10:16-20. 2009
    ..It may have therapeutic potential in the treatment of neurosurgical infections such as spinal osteomyelitis that are associated with significant morbidity rates...
  53. ncbi Sustained release of ciprofloxacin from an osteoconductive poly(DL)-lactide implant
    Jyri K Koort
    Department of Orthopaedic Surgery and Traumatology, University of Turku, Orthopaedic Research Unit, Turku, Finland
    Acta Orthop 79:295-301. 2008
    ..Antibiotic-releasing bioresorbable implants are used for local treatment of bone infections, but most drug delivery systems release antibiotic for too short a time...
  54. pmc Management of acute hematogenous osteomyelitis in children
    Nada S Harik
    Department of Pediatrics and Department of Microbiology and Immunology, University of Arkansas for Medical Sciences and the Arkansas Children s Hospital, Little Rock, AR 72205, USA
    Expert Rev Anti Infect Ther 8:175-81. 2010
    In children, osteomyelitis is primarily hematogenous in origin and acute in nature. The principal cause of osteomyelitis in children is Staphylococcus aureus, and both the epidemiology and pathogenesis of S...
  55. ncbi PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review
    Wouter van der Bruggen
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Semin Nucl Med 40:3-15. 2010
    ..To review the literature on diagnostic accuracy and clinical value of single-photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging of bone and joint infections...
  56. ncbi Tigecycline: first of a new class of antimicrobial agents
    Warren E Rose
    Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    Pharmacotherapy 26:1099-110. 2006
    ..Tigecycline has demonstrated promising results in initial in vitro and clinical studies for SSSIs and complicated intraabdominal infections; however, further clinical experience will clarify its role as a broad-spectrum agent...
  57. ncbi Reconstruction of segmental bone defects due to chronic osteomyelitis with use of an external fixator and an intramedullary nail
    Mehmet Kocaoglu
    Department of Orthopaedics and Traumatology, Istanbul Medical School, Istanbul University, Capa, 34390, Istanbul, Turkey
    J Bone Joint Surg Am 88:2137-45. 2006
    ..our experience with distraction osteogenesis performed with an external fixator combined with an intramedullary nail for the treatment of bone defects and limb-shortening resulting from radical débridement of chronic osteomyelitis.
  58. pmc The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis
    A H Montes
    Department of Biochemistry and Molecular Biology, Oviedo University Medical School and Hospital Central de Asturias, Oviedo, Spain
    Clin Exp Immunol 143:404-13. 2006
    b>Osteomyelitis is a bone infection caused mostly by Staphylococcus aureus but also by Gram-negative bacteria...
  59. ncbi Systemic versus local application of gentamicin in prophylaxis of implant-related osteomyelitis in a rat model
    M Lucke
    Center for Musculoskeletal Surgery, Charite University Medicine, Campus Virchow, D 13353 Berlin, Germany
    Bone 36:770-8. 2005
    ..treated with uncoated or PDLLA-coated Kirschner wires without systemic application of the antibiotic developed osteomyelitis and all cultures of implants were tested positive on S. aureus...
  60. ncbi Acute osteomyelitis in children: the pathogenesis revisited?
    J L Labbe
    Orthopedic and Traumatologic Surgery Dept, Nouméa Territorial Hospital, BP J5, Noumea, New Caledonia
    Orthop Traumatol Surg Res 96:268-75. 2010
    The present study reviews our experience of acute hematogenous osteomyelitis in 450 children over a period of 20 years from 1985 to 2004 at the Nouméa Territorial Hospital in New Caledonia...
  61. ncbi Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, Therapeutiques Cliniques et Experimentales des Infections, EA3826, F 44000 Nantes, France
    J Antimicrob Chemother 65:1749-52. 2010
    ..aureus (GISA) strains...
  62. ncbi Acute hematogenous osteomyelitis and septic arthritis in children: clinical characteristics and outcomes study
    Pisit Sukswai
    Department of Orthopedic Surgery, Queen Sirikit National Institute of Child Health, Bangkok, Thailand
    J Med Assoc Thai 94:S209-16. 2011
    To evaluate the clinical features, causative pathogens and outcomes-related to acute hematogenous osteomyelitis and septic arthritis in pediatric patients.
  63. ncbi A meta-analysis of fluorodeoxyglucose-positron emission tomography versus scintigraphy in the evaluation of suspected osteomyelitis
    Guo Lin Wang
    PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People s Republic of China
    Nucl Med Commun 32:1134-42. 2011
    Functional nuclear medicine imaging techniques have become particularly important in the diagnosis of osteomyelitis. The aim of our study was to perform a meta-analysis to obtain a reliable estimate of the diagnostic performance of ..
  64. pmc Establishment of a real-time, quantitative, and reproducible mouse model of Staphylococcus osteomyelitis using bioluminescence imaging
    Haruki Funao
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    Infect Immun 80:733-41. 2012
    b>Osteomyelitis remains a serious problem in the orthopedic field. There are only a few animal models in which the quantity and distribution of bacteria can be reproducibly traced...
  65. ncbi Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles
    Kuo Ti Peng
    Division of Sports Medicine, Department of Orthopedic Surgery, Chang Gung Memorial Hospital at Chia Yi, Taiwan, ROC
    Biomaterials 31:5227-36. 2010
    b>Osteomyelitis characterized by an inflammatory response often leads to bone loss and the spread of bacterial infection to surrounding soft tissues...
  66. pmc Surgical treatment of pyogenic vertebral osteomyelitis with spinal instrumentation
    Wei Hua Chen
    Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China
    Eur Spine J 16:1307-16. 2007
    Pyogenic vertebral osteomyelitis responds well to conservative treatment at early stage, but more complicated and advanced conditions, including mechanical spinal instability, epidural abscess formation, neurologic deficits, and ..
  67. ncbi Molecular analysis of community-acquired methicillin-susceptible and resistant Staphylococcus aureus isolates recovered from bacteraemic and osteomyelitis infections in children from Tunisia
    A Kechrid
    Laboratoire de Microbiologie, Hopital d Enfants de Tunis, Tunis, Tunisia
    Clin Microbiol Infect 17:1020-6. 2011
    ..girls) that fulfilled CDC criteria for community-acquired infections were diagnosed with bacteraemia and/or osteomyelitis caused by Staphylococcus aureus during an 18-month period (2006-2008)...
  68. pmc Titanium cages in the surgical treatment of severe vertebral osteomyelitis
    U Liljenqvist
    Department of Orthopedics, University Hospital of Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
    Eur Spine J 12:606-12. 2003
    ..In this study 20 patients with destructive vertebral osteomyelitis were surgically treated with one-stage posterior instrumentation and fusion and anterior debridement, ..
  69. ncbi Microbiology and management of joint and bone infections due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
    J Orthop Sci 13:160-9. 2008
    To describes the microbiology, diagnosis, and management of septic arthritis and osteomyelitis due to anaerobic bacteria.
  70. ncbi Vertebral osteomyelitis in Göteborg, Sweden: a retrospective study of patients during 1990-95
    M Beronius
    Department of Infectious Diseases Sahlgrenska University Hospital Ostra, , Sweden
    Scand J Infect Dis 33:527-32. 2001
    Vertebral osteomyelitis (VO) is a rare condition and the diagnosis is often overlooked initially. Delay in diagnosis may result in vertebral destruction or perforation of the spinal canal...
  71. ncbi Optimal duration of antibiotic therapy in vertebral osteomyelitis
    F Roblot
    Infectious Diseases Unit, CHU La Miletrie, Poitiers, France
    Semin Arthritis Rheum 36:269-77. 2007
    To compare the risk of relapse of vertebral osteomyelitis (VO), according to the duration of antibiotic therapy (< or =6 weeks versus >6 weeks).
  72. ncbi Nafcillin-loaded PLGA nanoparticles for treatment of osteomyelitis
    Rajeev Raghavan Pillai
    Department of Chemistry, Polymer Nanotechnology Laboratory, Center for Optoelectronics, University of North Carolina, Charlotte, NC 28223, USA
    Biomed Mater 3:034114. 2008
    ..This is important in order to treat Staphylococcus aureus-mediated osteomyelitis. The latter is often chronic and highly resistant to antibiotics...
  73. ncbi Vertebral osteomyelitis combined streptococcal viridans endocarditis
    Kuo Chen Lee
    Department of Surgery, Division of Cardiovascular Surgery, Tri Service General Hospital National Defense Medical Center, No 325, Cheng Kung Road Sec 2, Neihu 114, Taipei, Taiwan, ROC
    Eur J Cardiothorac Surg 23:125-7. 2003
    Endocarditis may be difficult to diagnose in patients with osteomyelitis in an early stage because they usually are treated for fever, bone pain and stiffness in the outpatient department...
  74. ncbi Chronic recurrent multifocal osteomyelitis
    Julien Wipff
    Service de Rhumatologie A, Universite Paris Descartes, AP HP, Hopital Cochin, Paris, France
    Joint Bone Spine 78:555-60. 2011
    Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial osteomyelitis, is an orphan disease that manifests as recurrent flares of inflammatory bone pain with or without a fever...
  75. ncbi Fibrous dysplasia of mandible with chronic osteomyelitis in a child: report of one case
    Chia Yau Chang
    Division of General Pediatrics, Department of Pediatrics, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan
    Acta Paediatr Taiwan 43:354-7. 2002
    ..She had a growing mass with local pain over right chin after a severe trauma, which was thought to be chronic osteomyelitis (OM)...
  76. ncbi Daptomycin treatment of Staphylococcus aureus experimental chronic osteomyelitis
    Mark S Rouse
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Antimicrob Chemother 57:301-5. 2006
    ..Daptomycin is a cyclic lipopeptide anti-infective with activity against MRSA, approved for treatment of complicated skin and skin structure infections. Daptomycin may be useful in systemic or local treatment of chronic osteomyelitis.
  77. ncbi Acute osteomyelitis, septic arthritis and discitis: differences between neonates and older children
    A C Offiah
    Department of Radiology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK
    Eur J Radiol 60:221-32. 2006
    ..Due to the anatomy and blood supply in neonates, osteomyelitis often co-exists with septic arthritis...
  78. ncbi Diagnostic criteria for the detection of mandibular osteomyelitis using cone-beam computed tomography
    D Schulze
    Department of Oral Radiology, Department of Oral and Maxillofacial Surgery, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Dentomaxillofac Radiol 35:232-5. 2006
    To investigate the usefulness of cone-beam computed tomography (CBCT) in cases of suspected osteomyelitis (OM) of the mandible.
  79. ncbi Implant-associated posttraumatic osteomyelitis: collateral damage by local host defense?
    C Wagner
    Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Clinic for Traumatology and Reconstructive Surgery, Ludwigshafen, Germany
    Int J Artif Organs 28:1172-80. 2005
    ..Infections following osteosynthesis or total joint replacement, also known as ''implant-associated posttraumatic osteomyelitis'', represent a major complication in orthopedic and trauma surgery...
  80. ncbi The role of thoracoscopic spinal surgery in the management of pyogenic vertebral osteomyelitis
    Thomas Muckley
    Department of Surgery, Trauma Center Murnau, Murnau, Germany
    Spine (Phila Pa 1976) 29:E227-33. 2004
    ..Case report, operative technique...
  81. ncbi Osteomyelitis and pyogenic sacroiliitis: A difficult diagnosis
    L S Ford
    Department of Paediatrics and Department of Orthopaedics, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    J Paediatr Child Health 40:317-9. 2004
    ..We describe a 12-year-old girl whose osteomyelitis and pyogenic sacroiliitis was initially misdiagnosed and discuss examination, investigation and management of ..
  82. ncbi Localized osteomyelitis secondary to endodontic-implant pathosis. A case report
    H I Sussman
    Department of Periodontics, New York University, NY
    J Periodontol 64:306-10. 1993
    ..Although endodontic therapy was performed within one week on the devitalized tooth, and extensive osteomyelitis developed around the implant. Three weeks after placement, the fixture had to be removed...
  83. ncbi Acute bone crises in sickle cell disease: the T1 fat-saturated sequence in differentiation of acute bone infarcts from acute osteomyelitis
    R Jain
    Department of Radiology, College of Medicine, Sultan Qaboos University, Muscat, Oman
    Clin Radiol 63:59-70. 2008
    ..by sequestration of red blood cells (RBCs) in bone marrow, and to evaluate the unenhanced T1 fat-saturated (fs) sequence in the differentiation of acute bone infarction from acute osteomyelitis in patients with sickle-cell disease.
  84. pmc Pyogenic vertebral osteomyelitis: identification of microorganism and laboratory markers used to predict clinical outcome
    Sang Hoon Yoon
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi dong, Bundang gu, Seongnam si, Gyeonggi do 463 707, Korea
    Eur Spine J 19:575-82. 2010
    The aim of this study is to determine the predictive values of laboratory indicators of pyogenic vertebral osteomyelitis (PVO) and a potential cure if the microorganism cannot be identified...
  85. ncbi Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new specific real-time PCR assay to the diagnosis
    Dimitri Ceroni
    Pediatric Orthopaedic Service, Department of Radiology, Service of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland
    J Pediatr Orthop 30:301-4. 2010
    ..kingae. In addition, we describe the usage of a new specific real-time PCR assay in children under 4 years admitted for OAI with a probe that detects 2 independent gene targets from the K. kingae RTX toxin...
  86. ncbi Community-associated methicillin-resistant Staphylococcus aureus in acute musculoskeletal infection in children: a game changer
    Kelly L Vander Have
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Pediatr Orthop 29:927-31. 2009
    ..The purpose of this study is to characterize the presentation, clinical course, treatment, complications, and long-term morbidity of CA-MRSA musculoskeletal infection in children...
  87. pmc Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus
    Jyri K Koort
    Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, FIN 20520 Turku, Finland
    Antimicrob Agents Chemother 49:1502-8. 2005
    ..The present experimental study was carried out to test this concept in a localized Staphylococcus aureus osteomyelitis model in the rabbit (n = 31)...
  88. ncbi Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children
    Sylvia Chometon
    Laboratoire de Bacteriologie, Hopital Cardiologique Louis Pradel, Lyon, France
    Pediatr Infect Dis J 26:377-81. 2007
    ..We developed a specific real-time PCR method to detect K. kingae DNA and applied it to the etiologic diagnosis of OAI...
  89. ncbi The use of allograft or autograft and expandable titanium cages for the treatment of vertebral osteomyelitis
    Daniel C Lu
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143 0350, USA
    Neurosurgery 64:122-9; discussion 129-30. 2009
    The results of the surgical treatment of osteomyelitis with expandable titanium cages and either allograft or autograft are presented.
  90. ncbi Safety and efficacy of daptomycin in the treatment of osteomyelitis: results from the CORE Registry
    J A Crompton
    Cubist Pharmaceuticals, Lexington, MA 02421, USA
    J Chemother 21:414-20. 2009
    Antibiotic safety is a major determinant in osteomyelitis therapy. Limited data is available describing the long-term safety and efficacy of daptomycin...
  91. ncbi Atypical mycobacterial vertebral osteomyelitis in a steroid-dependent adolescent. A case report
    T C Pruitt
    University of Arkansas for Medical Sciences, Little Rock
    Spine (Phila Pa 1976) 18:2553-5. 1993
    ..The authors present the case of a patient with vertebral osteomyelitis secondary to Mycobacterium chelonae subspecies abscessus that was successfully treated with surgical ..
  92. ncbi Better treatment of vertebral osteomyelitis using posterior stabilization and titanium mesh cages
    Hwan T Hee
    Spine Surgery PSC, Louisville, Kentucky, USA
    J Spinal Disord Tech 15:149-56; discussion 156. 2002
    There is no scientific consensus on the role of posterior instrumentation in vertebral osteomyelitis. No study has examined the use of titanium cages to reconstruct the anterior column of the spine with vertebral osteomyelitis...
  93. ncbi Sequential or simultaneous, same-day anterior decompression and posterior stabilization in the management of vertebral osteomyelitis of the lumbar spine
    O Safran
    Department of Orthopedic Surgery, Hadassah University Hospital, Jerusalem, Israel
    Spine (Phila Pa 1976) 23:1885-90. 1998
    STUDY DESIGN: A retrospective clinical study of patients with vertebral osteomyelitis of the lumbar spine necessitating surgical treatment...
  94. ncbi Osteomyelitis complicating pyomyositis in HIV disease
    Matthew S Buckland
    Department of Immunology, Imperial College, Hammersmith Campus, 10th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK
    Int J STD AIDS 15:632-4. 2004
    ..Pyomyositis and osteomyelitis are usually considered a late complication of advanced HIV disease...
  95. ncbi The diagnostic role of gadolinium enhanced MRI in distinguishing between acute medullary bone infarct and osteomyelitis
    H Umans
    Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
    Magn Reson Imaging 18:255-62. 2000
    ..contrast enhanced magnetic resonance imaging (MRI) for distinguishing between acute medullary bone infarct and osteomyelitis. There were 11 patients (age 6-34 years) presented to our institution between December 1994 and February 1998 ..
  96. ncbi Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery
    Caspar J Hodiamont
    Department of Medical Microbiology, Academic Medical Center, Amsterdam
    Med Mycol 47:217-20. 2009
    We describe a patient with chronic granulomatous disease and proven Aspergillus fumigatus osteomyelitis of the midfoot, while receiving itraconazole-prophylaxis...
  97. ncbi Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis
    M O Elasri
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Bone 30:275-80. 2002
    ..aureus UAMS-1, a strain that was originally isolated from the bone of a patient suffering from osteomyelitis. The mutant (UAMS-237) was unable to bind collagen but bound fibronectin at levels comparable to UAMS-1...
  98. ncbi Osteomyelitis in long bones
    Luca Lazzarini
    Infectious Disease Unit, Department of Internal Medicine, San Bortolo Hospital, Viale Rodolfi 47, 36100 Vicenza, Italy
    J Bone Joint Surg Am 86:2305-18. 2004
    b>Osteomyelitis in long bones remains challenging and expensive to treat, despite advances in antibiotics and new operative techniques. Plain radiographs still provide the best screening for acute and chronic osteomyelitis...
  99. pmc Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection
    Jon S Blevins
    Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 71:516-23. 2003
    ..aureus (UAMS-1). By using this model, we confirmed that mutation of sarA and/or agr results in a reduced capacity to cause both septic arthritis and osteomyelitis.
  100. pmc Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts
    Shankari N Somayaji
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Infect Immun 76:5120-6. 2008
    b>Osteomyelitis is an inflammatory disease of the bone that is characterized by the presence of necrotic bone tissue and increased osteoclast activity...
  101. ncbi BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method
    So Hee Kim
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
    Vaccine 26:4379-81. 2008
    Bacille Calmette-Guérin (BCG) osteitis is a rare complication of BCG vaccination. We describe two cases of BCG osteomyelitis developed in Korean infants who were given multipuncture BCG vaccination...

Research Grants63

  1. NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITY
    Jean Lee; Fiscal Year: 2003
    ..colonize epithelial surfaces, but it also has the invasive potential to cause severe infections, including osteomyelitis, endocarditis, and bacteremia with metastatic complications...
  2. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..It is also a fatal complication of chronic infectious diseases such as osteomyelitis in patients with paraplegia or quadriplegia...
  3. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..is associated mostly with chronic inflammatory disorders and includes patients with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's disease, renal cell ..
  4. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..gram-negative bacteremia, prostatitis, epididymitis, urosepsis, septicemia, orchitis, endocarditis, vertebral osteomyelitis, septic arthritis, endophthalmitis, and meningitis n all patients...
  5. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    ..Demonstrating the broad tissue range and virulence properties of the pathogen, S. aureus also causes osteomyelitis, septic arthritis, and a spectrum of toxin-mediated entities including staphylococcal toxic shock syndrome, ..
  6. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..skin and lead to invasive and frequently life-threatening infections such as lymphangitis, septic arthritis, osteomyelitis, bacteremia, pneumonia, abscesses of various organs, meningitis, endocarditis, and sepsis...
  7. Anti-Autolysin Passive Immunity for MRSA Osteomyelitis
    JOHN LINFORTH DAISS; Fiscal Year: 2010
    ..In Orthopaedics, MRSA osteomyelitis (OM) has become the greatest concern in patient care, desite the fact that improvements in surgical technique ..
  8. Diabetic Foot and Pressure Ulcer Databank
    Harold Brem; Fiscal Year: 2009
    ..treatment protocol is instituted, they heal;2) diabetic foot ulcers, in the absence of ischemia and osteomyelitis, heal when they are treated appropriately, thereby averting amputations...
  9. Rapid Novel Molecular Detection of Methicillin-Resistant Staphylococcus aureus
    ELENA ANATOLIEVNA USACHEVA; Fiscal Year: 2010
    ..diversity of diseases ranging from benign skin infection to life-threatening diseases such as endocarditis, osteomyelitis, rhinosinusitis, sepsis, necrotizing pneumonia...
  10. Hemostatic-antibiotic Combination for Prevention of MRSA Surgical Site Infections
    Timothy C Fisher; Fiscal Year: 2010
    ..the immediate post-operative period to reduce the probability of against infection of the wound or the bone (osteomyelitis) by methicillin- resistant Staphylococci (e.g...
  11. Cysteine Proteases in Apoptosis
    Emad S Alnemri; Fiscal Year: 2012
    ..diseases, known as pyogenic arthritis, pyoderma gangrenosum, acne syndrome (PAPA) and chronic multifocal osteomyelitis (cmo) syndrome, respectively...
  12. Improved manufacture of bone transport plates
    TIMOTHY MULONE; Fiscal Year: 2009
    ..may result from blast injuries, high impact trauma, or repeated surgical debridement for treatment of chronic osteomyelitis of the mandible...
  13. Genetic &immunologic etiology of chronic recurrent multifocal osteomyelitis-CRMO
    Polly J Ferguson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder that presents with painful, sterile inflammatory bone lesions...
  14. A Role of Osteoimmunology in Leptin-Regulated Bone Metabolism
    ERICA LYNN SCHELLER; Fiscal Year: 2010
    ..of creation and influence in the marrow cavity and has important implications for the study of inflammation-linked bone disorders including osteoporosis, cancer metastasis to the bone, arthritis, osteomyelitis and periodontal disease.
  15. Imaging the struggle for nutrient metal between host and pathogen
    Eric P Skaar; Fiscal Year: 2013
    ..in the United States and our laboratory is experienced in murine models of staphylococcal systemic infection, osteomyelitis, and pneumonia...
  16. Molecular basis of virulence in the emerging pathogen Kingella kingae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..invasive gram-negative pathogen that has been recognized recently as a leading cause of septic arthritis and osteomyelitis in young children, accounting for up to 78% of cases in children <4 years old...
  17. Staphylococcus aureus MSCRAMM SdrD in attachment and invasive disease
    Allison H Bartlett; Fiscal Year: 2010
    ..RELEVANCE (See instructions): Staphylococcus aureus is a major cause of infections including cellulitis and osteomyelitis, pneumonia, and sepsis...
  18. Image Guidance Method for Diabetic Foot Surgery
    IRVING WEINBERG; Fiscal Year: 2010
    ..overall goal of this project is to improve the care of diabetic patients undergoing surgery for treatment of osteomyelitis. This improvement will be attained by providing immediate intraoperative imaging feedback to podiatrists and ..
  19. Antimicrobial Biodegradable Bone Graft for Craniofacial/Maxillofacial Application
    Arash Aslani; Fiscal Year: 2013
    ..the surgeon must find a way to quickly repair the wound while reducing the risk of chronic infection or osteomyelitis. In the Phase I program, we propose to develop a superior local antibiotic delivery system (in the form of ..
  20. Osteogenic Calcium Phosphate Nanoparticles with Designable Drug Release Kinetics
    Vuk Uskoković; Fiscal Year: 2012
    ..of calcium phosphate/polymer composite particles that encapsulate clinmadycin, a drug used in the treatment of osteomyelitis, as well as testing of the antimicrobial properties and osteinductive performance of the given material in ..
  21. Nuclease-Activated Probes for Imaging Staphylococcus aureus Infections
    JAMES O apos CONNELL MCNAMARA; Fiscal Year: 2013
    ..are a major public health problem, responsible for debilitating and life-threatening conditions including osteomyelitis and infectious arthritis. Technologies that enable the detection and localization of S...
  22. Targeting Primary Immune Deficiency in Patient Populations
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..The commonest diagnoses were pneumonia, sepsis, failure to thrive, empyema, and bronchiectasis and osteomyelitis. Of 48 tested subjects of the 235 patients with more illnesses, 17 have primary immune deficiency (35%) and 4 ..
  23. Host determinants governing interactions with cytolethal distending toxins
    Aria Eshraghi; Fiscal Year: 2012
    ..oral abscesses, osteoclastogenesis and several extra-oral pathologies such as endocarditis, meningitis, and osteomyelitis. Epidemiological studies have shown that strains of A...
  24. Nanocarrier formulated enzyme for the treatment of S. aureus infection
    GERARDO M CASTILLO; Fiscal Year: 2013
    ..aureus (MRSA) mediated infections including endocarditis, osteomyelitis, catheter related infections, and MRSA-mediated community acquired furunculosis and pneumonia...
  25. Regulation of biofilm formation in clinical isolates of Staphylococcus aureus
    Mark S Smeltzer; Fiscal Year: 2013
    ..play a therapeutically defining role in many forms of Staphylococcus aureus infection including endocarditis, osteomyelitis, and infections associated with indwelling medical devices including orthpaedic implants...
  26. Quantitative ECT for Complex Imaging Tasks
    Stephen C Moore; Fiscal Year: 2012
    ..well as to treatment of hepatic tumors and metastases with 90Y- labeled microspheres, and to the diagnosis of osteomyelitis. We will extend our SPECT collimator design work to the case of simultaneous dual-radionuclide imaging, and to ..
  27. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..An animal model of foreign body osteomyelitis will be developed wherein wires will be inserted into the tibiae of rabbits and then contaminated with S...
  28. Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes
    David J Vachon; Fiscal Year: 2012
    ..can greatly complicate treatment and outcomes for diabetic foot ulcers with 65% of all patients developing osteomyelitis and amputation in 14-24% of the osteomyelitis group (American Diabetes Association, 1999)...
  29. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..pathogen responsible for a diverse spectrum of human and animal diseases, including wound infections, osteomyelitis, endocarditis, and bacteremia leading to secondary abscesses in any of the major organ systems...
  30. Pneumatic Robot for MRI-Guided Pediatrics Long Bone Biopsy
    Raymond Sze; Fiscal Year: 2013
    ..b>Osteomyelitis is a bone infection, with over 50% of reported cases seen in pre-school age children...
  31. Bone Targeting Peptides for the Prevention and Treatment of Infection
    HANNE GRON; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Osteomyelitis is a challenging infection of bone tissue, most often caused by a contaminated open fracture site after trauma,..
  32. Growth factor delivery patch for wound healing
    Fen Zhang; Fiscal Year: 2005
    ..Chronic skin wounds severely restrict a patient's mobility, and can lead to cellulitis, osteomyelitis, sepsis and death...
  33. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2005
    ..In this population, osteomyelitis and deep infection of the foot are relatively common complications...
  34. Preclinical Development of an Absorbable Antibacterial Bone Hemostatic Agent
    TIMOTHY FISHER; Fiscal Year: 2009
    ..but also releases gentamicin during the immediate post-operative period to prevent infection of the bone (osteomyelitis) or the rest of the wound...
  35. GENOME ANALYSIS OF STAPHYLOCOCCUS EPIDERMIDIS
    Steven Gill; Fiscal Year: 2001
    ..The infections caused by S. epidermidis include bacteremia, osteomyelitis, pyoarthritis and foreign body infections. Emergence of S...
  36. ELECTRON TRANSPORT VARIANTS IN STAPHYLOCOCCAL DISEASE
    Richard Proctor; Fiscal Year: 2001
    ..aureus osteomyelitis, ETVs were frequently found...
  37. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
    ..abnormalities of localized capillary beds often result in foot ulcers that do not heal leading to infection, osteomyelitis and amputation...
  38. Systemic AA Amyloidosis Inhibitors
    ALAN SNOW; Fiscal Year: 2004
    ..amyloidosis is associated with chronic inflammatory disorders and includes patients with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowel diseases, tuberculosis, leprosy, Hodgkin's disease, renal cell ..
  39. OSTEOMYELITIS THERAPY MONITORED BY ANTIBODIES, WBC & MRI
    Donald Schauwecker; Fiscal Year: 1993
    b>Osteomyelitis commonly occurs as a complication of bone surgery, open fracture, diabetic foot ulcer, penetrating wound, or similar condition...
  40. ORTHOPEDIC SEPSIS: PATHOGENESIS, DIAGNOSIS AND TREATMENT
    Robert Fitzgerald; Fiscal Year: 1991
    ..This application specifically addresses two types of musculoskeletal sepsis: acute hematogenous osteomyelitis (A.H.O.) and the infected total hip arthroplasty. There are five specific aims: 1) A.H.O...
  41. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2009
    ..Furthermore, the results of this research may impact the treatment of other biofilm-related diseases, such as osteomyelitis, endocarditis, prostatitis, otitis media, and sinusitis.
  42. A new absorbable antimicrobial bone graft substitute
    David Martin; Fiscal Year: 2005
    ..determine the feasibility of developing an absorbable antimicrobial bone graft substitute for the treatment of osteomyelitis. Osteomyelitis occurs in an estimated 1-3% of all orthopedic surgeries with the incidence being even higher in ..
  43. Magnetic Resonance Imaging Near Metallic Implants
    BRIAN ANDREW HARGREAVES; Fiscal Year: 2010
    ..Relevance: MRI is widely regarded as the best imaging modality for orthopedic conditions such as osteomyelitis, a vascular necrosis, tendon or ligamentous injury, bone or soft tissue lesions, spinal nerve root compression,..
  44. Computational model of cellular adhesion in bulk flows
    CHARLES EGGLETON; Fiscal Year: 2009
    ..lead to devastating consequences including sepsis with multi-organ failure, endocarditis, arthritis, vertebral osteomyelitis, epidural abscess and endophthalmitis...
  45. Subversion of innate immune responses by Brucella
    Sankar Ghosh; Fiscal Year: 2006
    ..intracellular bacterium that causes abortions in cattle and undulant fever, endocarditis, arthritis and osteomyelitis in humans...
  46. IL-1 and IL-1ra Stimulation of S aureus Replication
    SIVADASAN KANANGAT; Fiscal Year: 2003
    ..If it is not rapidly diagnosed and treated, it can lead to acute joint destruction, osteomyelitis, sepsis and even death. Staphylococcus aureus is the predominant organism invading the RA joints...
  47. ADHESINS AND STAPHYLOCOCCAL OSTEOMYELITIS
    Mark Smeltzer; Fiscal Year: 2000
    ..Strains isolated from patients suffering from osteomyelitis generally exhibit a high binding capacity for one or more of these host matrix proteins...
  48. BIODEGRADABLE POLYACTIDE-CO-GLYCOLIDE MEDICAL CEMENTS
    Larry Nichols; Fiscal Year: 2000
    b>Osteomyelitis is a serious orthopedic problem, and its prevention or treatment using systemic antibiotics is prone to complications and often unsuccessful...
  49. GENETIC AND CLINICAL STUDIES OF AD02
    MICHAEL ECONS; Fiscal Year: 2005
    ..Other features of the disease include nerve entrapment syndromes and osteomyelitis. Although the disorder is secondary to defects in osteoclast mediated bone resorption the pathophysiology of ..
  50. NOVEL 99MTC-TUFTSIN FOR IMAGING INFLAMMATION FOCI
    SHUBH SHARMA; Fiscal Year: 2000
    ..nuclear medicine for rapid imaging of suspected sites of infection and inflammation, including diagnosis of fevers of unknown origin, appendicitis, prosthetic infections, osteomyelitis, and opportunistic infections.
  51. LOCAL ANTIBIOTIC THERAPY OF OSTEOMYELITIS
    CLAYTON PERRY; Fiscal Year: 1990
    Chronic osteomyelitis is a difficult therapeutic problem, frequently resulting in long term disability. There are many facets of chronic osteomyelitis (eg...
  52. Investigating Substrate Specificity of Sortases
    Valerie Villareal; Fiscal Year: 2009
    Gram-positive bacteria are the causative agents of many nosocomial infections and diseases including osteomyelitis and pneumonia...
  53. Antibiotic resistance of S. aureus biofilms
    KIMBERLY JEFFERSON; Fiscal Year: 2005
    S. aureus is an important cause of biofilm-related infections such as endocarditis, chronic osteomyelitis, corneal infections involving lens implants, and medical device-related infections...
  54. NITRIC OXIDE REGULATION OF OSTEOBLASTS
    Peter Hauschka; Fiscal Year: 1999
    ..the extensive osteoclastic bone destruction in inflammatory bone diseases, including rheumatoid arthritis, osteomyelitis and periodontal disease, while simultaneously blocking the process of coupling which normal bone uses to ..
  55. Gene expression in S aureus biofilms
    KIMBERLY JEFFERSON; Fiscal Year: 2007
    ..S. aureus is an important cause of biofilm-related infections such as native valve endocarditis, osteomyelitis, and medical device-related infections...
  56. 99M TC-PHA-L4 LABELED LYMPHOCYTES
    Teresa Coons; Fiscal Year: 1991
    ..trafficking of stimulated lymphocytes and as a diagnostic radiopharmaceutical for chronic infections such as osteomyelitis and for granulomatous diseases...
  57. Pulmonary Arterial Hypertension: Avian Model of Complex Vascular Lesion Developme
    ROBERT WIDEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Bacterial infection induces cytokine production
    Ian Marriott; Fiscal Year: 2003
    ..abstract_text> ..
  59. Genetic Basis of chronic Multifocal Osteomyelitis
    Polly Ferguson; Fiscal Year: 2007
    Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone disease of unknown etiology. Clinically, the affected children present with recurrent fever and inflammatory bone lesions...
  60. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  61. Osteoblast-derived inflammatory mediators in infection
    Ian Marriott; Fiscal Year: 2004
    Staphylococcus aureus is the single most common cause of osteomyelitis in humans. Incidences of osteomyelitis caused by S...