- CT and MRI in tuberculous sternal osteomyelitis: a case report
Department of Radiology, Ibn i Sina Hospital, School of Medicine, Ankara University, 06100, Ankara, Turkey
Clin Imaging 26:112-5. 2002
..Treatment included both surgical intervention and medical therapy...
- Hematogenous vertebral osteomyelitis due to Staphylococcus aureus in the adult: clinical features and therapeutic outcomes
David H Priest
Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
South Med J 98:854-62. 2005
Staphylococcus aureus is the most common cause of hematogenous vertebral osteomyelitis in adults...
- Intracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitis
J Kent Ellington
Department of Orthopaedic Surgery, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, North Carolina 28223, USA
J Orthop Res 24:87-93. 2006
Staphylococcus aureus is responsible for 80% of human osteomyelitis. It can invade and persist within osteoblasts. Antibiotic resistant strains of S. aureus make successful treatment of osteomyelitis difficult...
Daniel P Lew
Services of Infectious Diseases and Medicine 2, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
Lancet 364:369-79. 2004
..The various types of osteomyelitis require differing medical and surgical therapeutic strategies...
- Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis
Microbial Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
PLoS ONE 7:e40586. 2012
Staphylococcus aureus is the most frequent causative organism of osteomyelitis. It is characterised by widespread bone loss and bone destruction. Previously we demonstrated that S...
- Panton-valentine leukocidin enhances the severity of community-associated methicillin-resistant Staphylococcus aureus rabbit osteomyelitis
Anne Claude Cremieux
Département de médecine aiguë, Hôpital Universitaire Raymond Poincaré, Assistance Publique Hopitaux de Paris, Garches, France
PLoS ONE 4:e7204. 2009
..in the United States, and the concomitant increase in severe invasive staphylococcal infections, including osteomyelitis, in healthy children, has led to renewed interest in Panton-Valentine leukocidin (PVL)...
- Characterization of a rabbit model of staphylococcal osteomyelitis
M S Smeltzer
Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
J Orthop Res 15:414-21. 1997
We previously described a rabbit osteomyelitis model that involved the direct introduction of Staphylococcus aureus into devascularized bone...
- Genome sequences of four divergent multidrug-resistant Acinetobacter baumannii strains isolated from patients with sepsis or osteomyelitis
Daniel V Zurawski
Walter Reed Army Institute of Research WRAIR, Department of Wound Infections, Silver Spring, Maryland, USA
J Bacteriol 194:1619-20. 2012
..Four A. baumannii strains from the Walter Reed Army Medical Center (WRAMC) isolated between 2008 and 2009 were sequenced, representing diverse, multidrug-resistant isolates from osteomyelitis or septic patients.
- Emerging pathogenetic mechanisms of the implant-related osteomyelitis by Staphylococcus aureus
Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy
Int J Artif Organs 34:781-8. 2011
Implant-related osteomyelitis is a severe and deep infection of bone that arises and develops all around an implant. Staphylococcus aureus is the first cause of osteomyelitis, whether implant-related or not...
- Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis
Francisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
J Clin Microbiol 44:595-7. 2006
..aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-..
- Osteomyelitis in military personnel wounded in Iraq and Afghanistan
Heather C Yun
Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
J Trauma 64:S163-8; discussion S168. 2008
..We describe demographics and microbiology of OIF/OEF casualties with primary and recurrent osteomyelitis.
- Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: a hospital-based cohort study in Japan
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54, Shogoin Kawahara cho, Kyoto 606 8507, Japan
Bone 51:882-7. 2012
..However, several studies have reported osteonecrosis of the jaw (ONJ), also known as osteomyelitis of the jaw (OMJ), as a side effect of these drugs...
- Osteomyelitis and the role of biofilms in chronic infection
Rebecca A Brady
Department of Microbiology and Immunology, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201, USA
FEMS Immunol Med Microbiol 52:13-22. 2008
- Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis
Otto S Kluin
Department of Biomedical Engineering, W J Kolff Institute, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Expert Opin Drug Deliv 10:341-51. 2013
Chronic osteomyelitis, or bone infection, is a major worldwide cause of morbidity and mortality, as it is exceptionally hard to treat due to patient and pathogen-associated factors...
- Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres
Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Turkey
Int J Pharm 317:127-35. 2006
..microspheres were implanted to proximal tibia of rats with methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. Intramuscular (IM) injection of VANCO for 21 days was applied to another group for comparison...
- Efficacy of anti-IL-1 treatment in Majeed syndrome
Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
Ann Rheum Dis 72:410-3. 2013
Majeed syndrome is an autosomal recessive disorder characterised by the triad of chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anaemia and a neutrophilic dermatosis that is caused by mutations in LPIN2...
- Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
Department of Orthopaedic Surgery, University Paris XII, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
Clin Orthop Relat Res 468:1676-81. 2010
Septic arthritis is a known complication of sickle cell disease (SCD) in children, and the association with osteomyelitis and osteonecrosis has been described. However, it is unclear whether this association applies to adults.
- The impact of the current epidemiology of pediatric musculoskeletal infection on evaluation and treatment guidelines
Omar A Gafur
University of Texas Southwestern, Dallas, TX, USA
J Pediatr Orthop 28:777-85. 2008
- Single-stage autogenous bone grafting and internal fixation in the surgical management of pyogenic discitis and vertebral osteomyelitis
G J Przybylski
Department of Neurosurgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Neurosurg 94:1-7. 2001
..Comparatively fewer patients with pyogenic discitis and vertebral osteomyelitis (PDVO) have undergone single-stage debridement, arthrodesis, and internal fixation...
- Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofa
Department of Biochemistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
J Bone Miner Metab 28:365-83. 2010
- Interaction of staphylococci with bone
John A Wright
Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
Int J Med Microbiol 300:193-204. 2010
- Mycobacterium ulcerans disease (Buruli ulcer) in a rural hospital in Bas-Congo, Democratic Republic of Congo, 2002-2004
Delphin M Phanzu
Institut Medical Evangelique, Kimpese Hospital, Kimpese, Bas Congo, Democratic Republic of Congo
Am J Trop Med Hyg 75:311-4. 2006
..Extensive clinical data, treatment outcomes, and socioeconomic correlations are summarized. Osteomyelitis was an important complication...
- (68)Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones
Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, Turku, Finland
Eur J Nucl Med Mol Imaging 35:352-64. 2008
- Intermediate vancomycin susceptibility in a community-associated MRSA clone
Christopher J Graber
Division of Infectious Diseases, University of California, San Francisco General Hospital, 94110, USA
Emerg Infect Dis 13:491-3. 2007
..The strain was isolated from the bone of a 56-year-old man with lumbar osteomyelitis after a 6-week treatment course of vancomycin for catheter-associated septic thrombophlebitis.
- Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblasts
Amy B Young
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Bone 48:857-63. 2011
..While inflammatory damage during conditions such as osteomyelitis is associated with increased formation and activity of bone-resorbing osteoclasts, it is likely that bone loss ..
- Delayed primary versus late secondary wound closure in the treatment of postsurgical sternum osteomyelitis
Denis A Berdajs
Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
Interact Cardiovasc Thorac Surg 12:914-8. 2011
Sternal osteomyelitis and poststernotomy mediastinitis is a severe and life-threatening complication after the cardiac surgery. The incidence ranges up to 3% with a mortality rate up to 29%...
- Efficacy of antibiotics-loaded interpenetrating network (IPNs) hydrogel based on poly(acrylic acid) and gelatin for treatment of experimental osteomyelitis: in vivo study
Centre for Biomedical Engineering, IIT Delhi, Hauz Khas, New Delhi 110016, India
Biomaterials 26:2095-104. 2005
..and drug-loaded device of AxGx (acrylic acid:gelatin: 1:1 w/w) were employed for the treatment of experimental osteomyelitis in rabbit. Rabbits were categorized into four groups...
- Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: prospective, randomized trial on 131 culture-positive cases
Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland
Pediatr Infect Dis J 29:1123-8. 2010
Considerable uncertainty exists on the optimal duration of antimicrobials for acute hematogenous osteomyelitis (AHOM) in children...
- Radiolucent inflammatory jaw lesions: a twenty-year analysis
Department of Oral Diagnostic and Surgical Sciences, University of Otago School of Dentistry, Dunedin, New Zealand
Int Endod J 43:859-65. 2010
..To determine the range and demographic and clinical features of radiolucent inflammatory jaw lesions...
- Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Immunol Res 30:291-308. 2004
..there is growing realization that osteoblasts have an additional function during bone diseases, such as osteomyelitis. Based on our recent studies, we propose a novel role for osteoblasts during bacterial infections of bone, ..
- Novel borate glass/chitosan composite as a delivery vehicle for teicoplanin in the treatment of chronic osteomyelitis
Wei Tao Jia
Department of Orthopedic Surgery, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Acta Biomater 6:812-9. 2010
..were investigated in vitro and in vivo as a new delivery system for teicoplanin in the treatment of chronic osteomyelitis induced by methicillin-resistant Staphylococcus aureus (MRSA)...
- Improvement of gentamicin poly(D,L-lactic-co-glycolic acid) microspheres for treatment of osteomyelitis induced by orthopedic procedures
Maria Rosa Virto
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University, Madrid 28040, Spain
Biomaterials 28:877-85. 2007
..Two models, one of them including an autocatalytic process, were finally proposed to contribute to understand the mass transport mechanism involved in drug release from these microspheres...
- Evaluation of an in situ setting injectable calcium phosphate as a new carrier material for gentamicin in the treatment of chronic osteomyelitis: studies in vitro and in vivo
Department of Trauma and Hand Surgery, Westfalian Wilhelms University of Munster, Muenster, Germany
Biomaterials 25:4287-95. 2004
..of hydroxyapatite cement (HAC) as a new carrier system in the treatment of chronic, posttraumatic osteomyelitis. In the in vitro study, release of gentamicin from standard cylinders of HAC were measured by agar diffusion ..
- The epidemiology of hematogenous vertebral osteomyelitis: a cohort study in a tertiary care hospital
Kavita P Bhavan
Division of Infectious Diseases, Washington University School of Medicine, St, Louis, MO, USA
BMC Infect Dis 10:158. 2010
Vertebral osteomyelitis is a common manifestation of osteomyelitis in adults and associated with considerable morbidity. Limited data exist regarding hematogenous vertebral osteomyelitis...
- Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
PLoS ONE 6:e18748. 2011
b>Osteomyelitis is a debilitating infectious disease of the bone. It is predominantly caused by S. aureus and is associated with significant morbidity and mortality...
- Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
J Orthop Res 26:96-105. 2008
Although osteomyelitis (OM) remains a serious problem in orthopedics, progress has been limited by the absence of an in vivo model that can quantify the bacterial load, metabolic activity of the bacteria over time, immunity, and ..
- Osteomyelitis and septic arthritis in children: current concepts
Emily R Dodwell
Hospital for Special Surgery, New York, New York 10021, USA
Curr Opin Pediatr 25:58-63. 2013
The cause, epidemiology, diagnosis, and treatment of osteoarticular infections have changed considerably in recent years. The current review includes the most up to date literature on pediatric septic arthritis and osteomyelitis.
- Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis
Carla Renata Arciola
Research Unit on Implant Infections, Rizzoli Orthopedic Institute, Bologna, Italy
Int J Artif Organs 35:713-26. 2012
..Implant-associated osteomyelitis is a deep infection of bone around the implant...
- Ceftobiprole efficacy in vitro against Panton-Valentine leukocidin production and in vivo against community-associated methicillin-resistant Staphylococcus aureus osteomyelitis in rabbits
Département de Médecine Aiguë Spécialisée, Hôpital Universitaire Raymond Poincaré, Assistance Publique Hopitaux de Paris, France
Antimicrob Agents Chemother 56:6291-7. 2012
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) can cause osteomyelitis with severe sepsis and/or local complications in which a Panton-Valentine leukocidin (PVL) role is suspected...
- Surgical amputation of a digit and vacuum-assisted-closure (V.A.C.) management in a case of osteomyelitis and wound care in an eastern black rhinoceros (Diceros bicornis michaeli)
Tara M Harrison
Potter Park Zoo, 1301 South Pennsylvania, Lansing, Michigan 48912, USA
J Zoo Wildl Med 42:317-21. 2011
A 14-yr-old female eastern black rhinoceros (Diceros bicornis michaeli) presented with progressive suppurative osteomyelitis in her left hind lateral toe. beta-Hemolytic Streptococcus sp. was isolated...
- Randomized controlled trial of the safety and efficacy of Daptomycin versus standard-of-care therapy for management of patients with osteomyelitis associated with prosthetic devices undergoing two-stage revision arthroplasty
Nuffield Orthopaedic Centre, Oxford, United Kingdom
Antimicrob Agents Chemother 56:5626-32. 2012
..In conclusion, daptomycin at 6 and 8 mg/kg given for up to 6 weeks was safe and appeared to be effective in managing staphylococcal PJI using a 2-stage revision arthroplasty technique in a total of 49 patients...
- A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis
Sarah A Horst
Infection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
Am J Pathol 181:1206-14. 2012
b>Osteomyelitis is a serious bone infection typically caused by Staphylococcus aureus. The pathogenesis of osteomyelitis remains poorly understood, mainly for lack of experimental models that closely mimic human disease...
- Anti-infection tissue engineering construct treating osteomyelitis in rabbit tibia
Department of Orthopaedics, Southwest Hospital, Chongqing, China
Tissue Eng Part A 19:255-63. 2013
..a fibrin gel scaffold and vancomycin alginate beads (Vanco-AB) to form composites, in the treatment of chronic osteomyelitis with bone defect in rabbit tibia. The infected bone defect model of rabbit tibia was established...
- Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature
Maidstone and Tunbridge Wells NHS Trust, Pembury, UK
J Bone Joint Surg Br 94:584-95. 2012
A delay in the diagnosis of paediatric acute and subacute haematogenous osteomyelitis can lead to potentially devastating morbidity...
- Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle
Internal Medicine, Bone Mineral Metabolism Unit, University of Verona, Verona, Italy
Nat Clin Pract Oncol 4:711-21. 2007
..of decreased production of cytokines derived from the bone matrix, and the bone is exposed to the risk of osteomyelitis and necrosis...
- A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: description of two unrelated cases from Brazil
Adriana A Jesus
Universidade de Sao Paulo, Sao Paulo, Brazil
Arthritis Rheum 63:4007-17. 2011
..This study was undertaken to present the characteristics of the DIRA syndrome in 2 cases from Brazil, and describe a novel mutation in IL1RN...
- Treatment of chronic femoral osteomyelitis with platelet-rich plasma (PRP): a case report
Orthopaedic Department, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai, China
Transfus Apher Sci 38:167-73. 2008
Chronic osteomyelitis is a serious problem in developing countries...
- A simple infection model using pre-colonized implants to reproduce rat chronic Staphylococcus aureus osteomyelitis and study antibiotic treatment
CSIC SIA, Department of Animal Health, Zaragoza, Spain
J Orthop Res 19:820-6. 2001
..In this work, a novel chronic osteomyelitis infection model was developed in rats in the absence of bacterial suspension, requiring the use of only 10(6) ..
- Pneumococcal vertebral osteomyelitis: a unique case with atypical clinical course
Department of Orthopaedics and Traumatology, Göztepe SSK Educational Hospital, Kadikoy, Istanbul, Turkey
Spine (Phila Pa 1976) 26:2397-9. 2001
..A case report...
- Antibiotic treatment for acute haematogenous osteomyelitis of childhood: moving towards shorter courses and oral administration
Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland
Int J Antimicrob Agents 38:273-80. 2011
Acute haematogenous osteomyelitis (AHOM) of childhood usually affects the long bones of the lower limbs...
- A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis
James E Cassat
Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Cell Host Microbe 13:759-72. 2013
b>Osteomyelitis is a common manifestation of invasive Staphylococcus aureus infection. Pathogen-induced bone destruction limits antimicrobial penetration to the infectious focus and compromises treatment of osteomyelitis...
- Role of hyperbaric oxygen therapy in the treatment of bacterial spinal osteomyelitis
The University of Iowa, Department of Neurosurgery, Iowa City, Iowa, USA
J Neurosurg Spine 10:16-20. 2009
..It may have therapeutic potential in the treatment of neurosurgical infections such as spinal osteomyelitis that are associated with significant morbidity rates...
- Sustained release of ciprofloxacin from an osteoconductive poly(DL)-lactide implant
Jyri K Koort
Department of Orthopaedic Surgery and Traumatology, University of Turku, Orthopaedic Research Unit, Turku, Finland
Acta Orthop 79:295-301. 2008
..Antibiotic-releasing bioresorbable implants are used for local treatment of bone infections, but most drug delivery systems release antibiotic for too short a time...
- Management of acute hematogenous osteomyelitis in children
Nada S Harik
Department of Pediatrics and Department of Microbiology and Immunology, University of Arkansas for Medical Sciences and the Arkansas Children s Hospital, Little Rock, AR 72205, USA
Expert Rev Anti Infect Ther 8:175-81. 2010
In children, osteomyelitis is primarily hematogenous in origin and acute in nature. The principal cause of osteomyelitis in children is Staphylococcus aureus, and both the epidemiology and pathogenesis of S...
- PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review
Wouter van der Bruggen
Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
Semin Nucl Med 40:3-15. 2010
..To review the literature on diagnostic accuracy and clinical value of single-photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging of bone and joint infections...
- Tigecycline: first of a new class of antimicrobial agents
Warren E Rose
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Pharmacotherapy 26:1099-110. 2006
..Tigecycline has demonstrated promising results in initial in vitro and clinical studies for SSSIs and complicated intraabdominal infections; however, further clinical experience will clarify its role as a broad-spectrum agent...
- Reconstruction of segmental bone defects due to chronic osteomyelitis with use of an external fixator and an intramedullary nail
Department of Orthopaedics and Traumatology, Istanbul Medical School, Istanbul University, Capa, 34390, Istanbul, Turkey
J Bone Joint Surg Am 88:2137-45. 2006
..our experience with distraction osteogenesis performed with an external fixator combined with an intramedullary nail for the treatment of bone defects and limb-shortening resulting from radical débridement of chronic osteomyelitis.
- The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis
A H Montes
Department of Biochemistry and Molecular Biology, Oviedo University Medical School and Hospital Central de Asturias, Oviedo, Spain
Clin Exp Immunol 143:404-13. 2006
b>Osteomyelitis is a bone infection caused mostly by Staphylococcus aureus but also by Gram-negative bacteria...
- Systemic versus local application of gentamicin in prophylaxis of implant-related osteomyelitis in a rat model
Center for Musculoskeletal Surgery, Charite University Medicine, Campus Virchow, D 13353 Berlin, Germany
Bone 36:770-8. 2005
..treated with uncoated or PDLLA-coated Kirschner wires without systemic application of the antibiotic developed osteomyelitis and all cultures of implants were tested positive on S. aureus...
- Acute osteomyelitis in children: the pathogenesis revisited?
J L Labbe
Orthopedic and Traumatologic Surgery Dept, Nouméa Territorial Hospital, BP J5, Noumea, New Caledonia
Orthop Traumatol Surg Res 96:268-75. 2010
The present study reviews our experience of acute hematogenous osteomyelitis in 450 children over a period of 20 years from 1985 to 2004 at the Nouméa Territorial Hospital in New Caledonia...
- Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis
Universite de Nantes, Faculte de Medecine, Therapeutiques Cliniques et Experimentales des Infections, EA3826, F 44000 Nantes, France
J Antimicrob Chemother 65:1749-52. 2010
..aureus (GISA) strains...
- Acute hematogenous osteomyelitis and septic arthritis in children: clinical characteristics and outcomes study
Department of Orthopedic Surgery, Queen Sirikit National Institute of Child Health, Bangkok, Thailand
J Med Assoc Thai 94:S209-16. 2011
To evaluate the clinical features, causative pathogens and outcomes-related to acute hematogenous osteomyelitis and septic arthritis in pediatric patients.
- A meta-analysis of fluorodeoxyglucose-positron emission tomography versus scintigraphy in the evaluation of suspected osteomyelitis
Guo Lin Wang
PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People s Republic of China
Nucl Med Commun 32:1134-42. 2011
Functional nuclear medicine imaging techniques have become particularly important in the diagnosis of osteomyelitis. The aim of our study was to perform a meta-analysis to obtain a reliable estimate of the diagnostic performance of ..
- Establishment of a real-time, quantitative, and reproducible mouse model of Staphylococcus osteomyelitis using bioluminescence imaging
Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
Infect Immun 80:733-41. 2012
b>Osteomyelitis remains a serious problem in the orthopedic field. There are only a few animal models in which the quantity and distribution of bacteria can be reproducibly traced...
- Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles
Kuo Ti Peng
Division of Sports Medicine, Department of Orthopedic Surgery, Chang Gung Memorial Hospital at Chia Yi, Taiwan, ROC
Biomaterials 31:5227-36. 2010
b>Osteomyelitis characterized by an inflammatory response often leads to bone loss and the spread of bacterial infection to surrounding soft tissues...
- Surgical treatment of pyogenic vertebral osteomyelitis with spinal instrumentation
Wei Hua Chen
Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China
Eur Spine J 16:1307-16. 2007
Pyogenic vertebral osteomyelitis responds well to conservative treatment at early stage, but more complicated and advanced conditions, including mechanical spinal instability, epidural abscess formation, neurologic deficits, and ..
- Molecular analysis of community-acquired methicillin-susceptible and resistant Staphylococcus aureus isolates recovered from bacteraemic and osteomyelitis infections in children from Tunisia
Laboratoire de Microbiologie, Hopital d Enfants de Tunis, Tunis, Tunisia
Clin Microbiol Infect 17:1020-6. 2011
..girls) that fulfilled CDC criteria for community-acquired infections were diagnosed with bacteraemia and/or osteomyelitis caused by Staphylococcus aureus during an 18-month period (2006-2008)...
- Titanium cages in the surgical treatment of severe vertebral osteomyelitis
Department of Orthopedics, University Hospital of Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
Eur Spine J 12:606-12. 2003
..In this study 20 patients with destructive vertebral osteomyelitis were surgically treated with one-stage posterior instrumentation and fusion and anterior debridement, ..
- Microbiology and management of joint and bone infections due to anaerobic bacteria
Department of Pediatrics, Georgetown University, School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
J Orthop Sci 13:160-9. 2008
To describes the microbiology, diagnosis, and management of septic arthritis and osteomyelitis due to anaerobic bacteria.
- Vertebral osteomyelitis in GÃ¶teborg, Sweden: a retrospective study of patients during 1990-95
Department of Infectious Diseases Sahlgrenska University Hospital Ostra, , Sweden
Scand J Infect Dis 33:527-32. 2001
Vertebral osteomyelitis (VO) is a rare condition and the diagnosis is often overlooked initially. Delay in diagnosis may result in vertebral destruction or perforation of the spinal canal...
- Optimal duration of antibiotic therapy in vertebral osteomyelitis
Infectious Diseases Unit, CHU La Miletrie, Poitiers, France
Semin Arthritis Rheum 36:269-77. 2007
To compare the risk of relapse of vertebral osteomyelitis (VO), according to the duration of antibiotic therapy (< or =6 weeks versus >6 weeks).
- Nafcillin-loaded PLGA nanoparticles for treatment of osteomyelitis
Rajeev Raghavan Pillai
Department of Chemistry, Polymer Nanotechnology Laboratory, Center for Optoelectronics, University of North Carolina, Charlotte, NC 28223, USA
Biomed Mater 3:034114. 2008
..This is important in order to treat Staphylococcus aureus-mediated osteomyelitis. The latter is often chronic and highly resistant to antibiotics...
- Vertebral osteomyelitis combined streptococcal viridans endocarditis
Kuo Chen Lee
Department of Surgery, Division of Cardiovascular Surgery, Tri Service General Hospital National Defense Medical Center, No 325, Cheng Kung Road Sec 2, Neihu 114, Taipei, Taiwan, ROC
Eur J Cardiothorac Surg 23:125-7. 2003
Endocarditis may be difficult to diagnose in patients with osteomyelitis in an early stage because they usually are treated for fever, bone pain and stiffness in the outpatient department...
- Chronic recurrent multifocal osteomyelitis
Service de Rhumatologie A, Universite Paris Descartes, AP HP, Hopital Cochin, Paris, France
Joint Bone Spine 78:555-60. 2011
Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial osteomyelitis, is an orphan disease that manifests as recurrent flares of inflammatory bone pain with or without a fever...
- Fibrous dysplasia of mandible with chronic osteomyelitis in a child: report of one case
Chia Yau Chang
Division of General Pediatrics, Department of Pediatrics, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan
Acta Paediatr Taiwan 43:354-7. 2002
..She had a growing mass with local pain over right chin after a severe trauma, which was thought to be chronic osteomyelitis (OM)...
- Daptomycin treatment of Staphylococcus aureus experimental chronic osteomyelitis
Mark S Rouse
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
J Antimicrob Chemother 57:301-5. 2006
..Daptomycin is a cyclic lipopeptide anti-infective with activity against MRSA, approved for treatment of complicated skin and skin structure infections. Daptomycin may be useful in systemic or local treatment of chronic osteomyelitis.
- Acute osteomyelitis, septic arthritis and discitis: differences between neonates and older children
A C Offiah
Department of Radiology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK
Eur J Radiol 60:221-32. 2006
..Due to the anatomy and blood supply in neonates, osteomyelitis often co-exists with septic arthritis...
- Diagnostic criteria for the detection of mandibular osteomyelitis using cone-beam computed tomography
Department of Oral Radiology, Department of Oral and Maxillofacial Surgery, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
Dentomaxillofac Radiol 35:232-5. 2006
To investigate the usefulness of cone-beam computed tomography (CBCT) in cases of suspected osteomyelitis (OM) of the mandible.
- Implant-associated posttraumatic osteomyelitis: collateral damage by local host defense?
Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Clinic for Traumatology and Reconstructive Surgery, Ludwigshafen, Germany
Int J Artif Organs 28:1172-80. 2005
..Infections following osteosynthesis or total joint replacement, also known as ''implant-associated posttraumatic osteomyelitis'', represent a major complication in orthopedic and trauma surgery...
- The role of thoracoscopic spinal surgery in the management of pyogenic vertebral osteomyelitis
Department of Surgery, Trauma Center Murnau, Murnau, Germany
Spine (Phila Pa 1976) 29:E227-33. 2004
..Case report, operative technique...
- Osteomyelitis and pyogenic sacroiliitis: A difficult diagnosis
L S Ford
Department of Paediatrics and Department of Orthopaedics, Royal North Shore Hospital, St Leonards, New South Wales, Australia
J Paediatr Child Health 40:317-9. 2004
..We describe a 12-year-old girl whose osteomyelitis and pyogenic sacroiliitis was initially misdiagnosed and discuss examination, investigation and management of ..
- Localized osteomyelitis secondary to endodontic-implant pathosis. A case report
H I Sussman
Department of Periodontics, New York University, NY
J Periodontol 64:306-10. 1993
..Although endodontic therapy was performed within one week on the devitalized tooth, and extensive osteomyelitis developed around the implant. Three weeks after placement, the fixture had to be removed...
- Acute bone crises in sickle cell disease: the T1 fat-saturated sequence in differentiation of acute bone infarcts from acute osteomyelitis
Department of Radiology, College of Medicine, Sultan Qaboos University, Muscat, Oman
Clin Radiol 63:59-70. 2008
..by sequestration of red blood cells (RBCs) in bone marrow, and to evaluate the unenhanced T1 fat-saturated (fs) sequence in the differentiation of acute bone infarction from acute osteomyelitis in patients with sickle-cell disease.
- Pyogenic vertebral osteomyelitis: identification of microorganism and laboratory markers used to predict clinical outcome
Sang Hoon Yoon
Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi dong, Bundang gu, Seongnam si, Gyeonggi do 463 707, Korea
Eur Spine J 19:575-82. 2010
The aim of this study is to determine the predictive values of laboratory indicators of pyogenic vertebral osteomyelitis (PVO) and a potential cure if the microorganism cannot be identified...
- Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new specific real-time PCR assay to the diagnosis
Pediatric Orthopaedic Service, Department of Radiology, Service of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland
J Pediatr Orthop 30:301-4. 2010
..kingae. In addition, we describe the usage of a new specific real-time PCR assay in children under 4 years admitted for OAI with a probe that detects 2 independent gene targets from the K. kingae RTX toxin...
- Community-associated methicillin-resistant Staphylococcus aureus in acute musculoskeletal infection in children: a game changer
Kelly L Vander Have
Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA
J Pediatr Orthop 29:927-31. 2009
..The purpose of this study is to characterize the presentation, clinical course, treatment, complications, and long-term morbidity of CA-MRSA musculoskeletal infection in children...
- Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus
Jyri K Koort
Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, FIN 20520 Turku, Finland
Antimicrob Agents Chemother 49:1502-8. 2005
..The present experimental study was carried out to test this concept in a localized Staphylococcus aureus osteomyelitis model in the rabbit (n = 31)...
- Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children
Laboratoire de Bacteriologie, Hopital Cardiologique Louis Pradel, Lyon, France
Pediatr Infect Dis J 26:377-81. 2007
..We developed a specific real-time PCR method to detect K. kingae DNA and applied it to the etiologic diagnosis of OAI...
- The use of allograft or autograft and expandable titanium cages for the treatment of vertebral osteomyelitis
Daniel C Lu
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143 0350, USA
Neurosurgery 64:122-9; discussion 129-30. 2009
The results of the surgical treatment of osteomyelitis with expandable titanium cages and either allograft or autograft are presented.
- Safety and efficacy of daptomycin in the treatment of osteomyelitis: results from the CORE Registry
J A Crompton
Cubist Pharmaceuticals, Lexington, MA 02421, USA
J Chemother 21:414-20. 2009
Antibiotic safety is a major determinant in osteomyelitis therapy. Limited data is available describing the long-term safety and efficacy of daptomycin...
- Atypical mycobacterial vertebral osteomyelitis in a steroid-dependent adolescent. A case report
T C Pruitt
University of Arkansas for Medical Sciences, Little Rock
Spine (Phila Pa 1976) 18:2553-5. 1993
..The authors present the case of a patient with vertebral osteomyelitis secondary to Mycobacterium chelonae subspecies abscessus that was successfully treated with surgical ..
- Better treatment of vertebral osteomyelitis using posterior stabilization and titanium mesh cages
Hwan T Hee
Spine Surgery PSC, Louisville, Kentucky, USA
J Spinal Disord Tech 15:149-56; discussion 156. 2002
There is no scientific consensus on the role of posterior instrumentation in vertebral osteomyelitis. No study has examined the use of titanium cages to reconstruct the anterior column of the spine with vertebral osteomyelitis...
- Sequential or simultaneous, same-day anterior decompression and posterior stabilization in the management of vertebral osteomyelitis of the lumbar spine
Department of Orthopedic Surgery, Hadassah University Hospital, Jerusalem, Israel
Spine (Phila Pa 1976) 23:1885-90. 1998
STUDY DESIGN: A retrospective clinical study of patients with vertebral osteomyelitis of the lumbar spine necessitating surgical treatment...
- Osteomyelitis complicating pyomyositis in HIV disease
Matthew S Buckland
Department of Immunology, Imperial College, Hammersmith Campus, 10th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK
Int J STD AIDS 15:632-4. 2004
..Pyomyositis and osteomyelitis are usually considered a late complication of advanced HIV disease...
- The diagnostic role of gadolinium enhanced MRI in distinguishing between acute medullary bone infarct and osteomyelitis
Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
Magn Reson Imaging 18:255-62. 2000
..contrast enhanced magnetic resonance imaging (MRI) for distinguishing between acute medullary bone infarct and osteomyelitis. There were 11 patients (age 6-34 years) presented to our institution between December 1994 and February 1998 ..
- Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery
Caspar J Hodiamont
Department of Medical Microbiology, Academic Medical Center, Amsterdam
Med Mycol 47:217-20. 2009
We describe a patient with chronic granulomatous disease and proven Aspergillus fumigatus osteomyelitis of the midfoot, while receiving itraconazole-prophylaxis...
- Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis
M O Elasri
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Bone 30:275-80. 2002
..aureus UAMS-1, a strain that was originally isolated from the bone of a patient suffering from osteomyelitis. The mutant (UAMS-237) was unable to bind collagen but bound fibronectin at levels comparable to UAMS-1...
- Osteomyelitis in long bones
Infectious Disease Unit, Department of Internal Medicine, San Bortolo Hospital, Viale Rodolfi 47, 36100 Vicenza, Italy
J Bone Joint Surg Am 86:2305-18. 2004
b>Osteomyelitis in long bones remains challenging and expensive to treat, despite advances in antibiotics and new operative techniques. Plain radiographs still provide the best screening for acute and chronic osteomyelitis...
- Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection
Jon S Blevins
Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Infect Immun 71:516-23. 2003
..aureus (UAMS-1). By using this model, we confirmed that mutation of sarA and/or agr results in a reduced capacity to cause both septic arthritis and osteomyelitis.
- Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts
Shankari N Somayaji
Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
Infect Immun 76:5120-6. 2008
b>Osteomyelitis is an inflammatory disease of the bone that is characterized by the presence of necrotic bone tissue and increased osteoclast activity...
- BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method
So Hee Kim
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
Vaccine 26:4379-81. 2008
Bacille Calmette-Guérin (BCG) osteitis is a rare complication of BCG vaccination. We describe two cases of BCG osteomyelitis developed in Korean infants who were given multipuncture BCG vaccination...