Genomes and Genes
community acquired infections
Summary: Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
Publications297 found, 100 shown here
- Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureusM C Enright
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
J Clin Microbiol 38:1008-15. 2000..MLST provides an unambiguous method for assigning MRSA and MSSA isolates to known clones or assigning them as novel clones via the Internet...
- Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adultsLionel A Mandell
McMaster University Medical School, Hamilton, Ontario, Canada
Clin Infect Dis 44:S27-72. 2007
- Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation studyW S Lim
Respiratory Infection Research Group, Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
Thorax 58:377-82. 2003..A multicentre study was conducted to derive and validate a practical severity assessment model for stratifying adults hospitalised with CAP into different management groups...
- Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureusBinh An Diep
Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94143, USA
Lancet 367:731-9. 2006..Our aim was to sequence its genome and compare it with those of other strains of S aureus to try to identify genes responsible for its distinctive epidemiological and virulence properties...
- Invasive methicillin-resistant Staphylococcus aureus infections in the United StatesR Monina Klevens
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
JAMA 298:1763-71. 2007..As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed...
- Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infectionTimothy S Naimi
Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
JAMA 290:2976-84. 2003..However, MRSA has emerged in patients without established risk factors (community-associated MRSA)...
- Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infectionsUlrich Seybold
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Clin Infect Dis 42:647-56. 2006..Whether community-associated methicillin-resistant Staphylococcus aureus (MRSA) genotypes (e.g., USA300) are a major cause of bloodstream infections (BSIs) and health care-associated infections has been poorly defined...
- Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infectionsN Deborah Friedman
Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
Ann Intern Med 137:791-7. 2002..Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections...
- Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergenceFrancois Vandenesch
INSERM E0230, Lyon, France
Emerg Infect Dis 9:978-84. 2003..Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA...
- Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated diseaseSandra Dial
Division of Critical Care and Respiratory and Clinical Research, Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec
JAMA 294:2989-95. 2005..Recent reports suggest an increasing occurrence and severity of Clostridium difficile-associated disease. We assessed whether the use of gastric acid-suppressive agents is associated with an increased risk in the community...
- Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumoniaSebastien Gibot
Service de Reanimation Medicale, Hopital Central, Nancy, France
N Engl J Med 350:451-8. 2004..The presence of soluble TREM-1 (sTREM-1) in bronchoalveolar-lavage fluid from patients receiving mechanical ventilation may be an indicator of pneumonia...
- Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelinesW S Lim
Respiratory Infection Research Group, Respiratory Medicine, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Thorax 56:296-301. 2001..Atypical pathogens are more common in younger patients. They should also be covered in all patients with severe pneumonia and younger patients with non-severe infection...
- Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odysseyStan Deresinski
Division of Infectious Disease and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Clin Infect Dis 40:562-73. 2005..This has led to an important change in the choice of antibiotics in the management of community-acquired infections and has also led to the development of novel antimicrobials...
- Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factorsCassandra D Salgado
University of Virginia Health System, Charlottesville, VA 22908, USA
Clin Infect Dis 36:131-9. 2003..24%). Effective control of dissemination of MRSA throughout the community likely will require effective control of nosocomial MRSA transmission...
- Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patternsWen Chien Ko
National Cheng Kung University Medical College, Taiwan
Emerg Infect Dis 8:160-6. 2002..A distinctive form of K. pneumoniae infection, often causing liver abscess, was identified, almost exclusively in Taiwan...
- Community-associated methicillin-resistant Staphylococcus aureus in hospital nursery and maternity unitsSimona Bratu
State University of New York Downstate, Brooklyn, New York 11203, USA
Emerg Infect Dis 11:808-13. 2005..CA-MRSA strain MW2 has been present in this region at least since 1999. This study documents the spread of this strain among healthy newborns at 1 hospital...
- Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?Tony Dremsizov
606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
Chest 129:968-78. 2006....
- Trends in hospitalizations for pneumonia among persons aged 65 years or older in the United States, 1988-2002Alicia M Fry
Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 294:2712-9. 2005..Pneumonia causes significant mortality and morbidity among persons aged 65 years or older. However, few studies have explored trends according to age groups, which may affect intervention strategies...
- A U.S. population-based survey of Staphylococcus aureus colonizationPhilip L Graham
Department of Pediatrics, Columbia University and New York Presbyterian Medical Center, New York, New York 10032, USA
Ann Intern Med 144:318-25. 2006..The epidemiology of staphylococcal colonization and community-associated methicillin-resistant Staphylococcus aureus (MRSA) is changing, and little is known from the national perspective...
- Validation of a predictive rule for the management of community-acquired pneumoniaA Capelastegui
Service of Pneumology, Hospital de Galdakao, E 48960 Galdakao, Bizkaia, Spain
Eur Respir J 27:151-7. 2006..The new score can also be used as a severity adjustment measure...
- Pneumonia: still the old man's friend?Vladimir Kaplan
Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
Arch Intern Med 163:317-23. 2003..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP...
- Health care-associated pneumonia and community-acquired pneumonia: a single-center experienceScott T Micek
Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO, USA
Antimicrob Agents Chemother 51:3568-73. 2007..Health care providers should differentiate patients with HCAP from those with CAP in order to provide more appropriate initial antimicrobial therapy...
- CRB-65 predicts death from community-acquired pneumoniaT T Bauer
HELIOS Clinic Emil v Behring, Respiratory Diseases Clinic Heckeshorn, Berlin, Germany
J Intern Med 260:93-101. 2006..The study was performed to validate the CURB, CRB and CRB-65 scores for the prediction of death from community-acquired pneumonia (CAP) in both the hospital and out-patient setting...
- Common community acquired infections and subsequent risk of chronic lymphocytic leukaemiaLesley A Anderson
Centre for Public Health, Queen s University Belfast, Belfast, Northern Ireland, UK
Br J Haematol 147:444-9. 2009..CLL patients and 122,531 frequency-matched controls were identified in order to evaluate several community acquired infections associated with subsequent CLL risk...
- Health care-associated pneumonia requiring hospital admission: epidemiology, antibiotic therapy, and clinical outcomesJordi Carratala
Infectious Disease Service, Hospital Universitari de Bellvitge, Feixa Llarga s n, 08907 L Hospitalet, Barcelona, Spain
Arch Intern Med 167:1393-9. 2007..However, limited data exist to validate this entity. We aimed to ascertain the epidemiology, causative organisms, antibiotic susceptibilities, and outcomes of and empirical antibiotic therapy for HCAP requiring hospitalization...
- Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?Kyle J Popovich
Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
Clin Infect Dis 46:787-94. 2008..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
- Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumoniaPeter M Houck
Centers for Medicare and Medicaid Services, Seattle, WA 98121, USA
Arch Intern Med 164:637-44. 2004..Pneumonia accounts for more than 600 000 Medicare hospitalizations yearly. Guidelines have recommended antibiotic treatment within 8 hours of arrival at the hospital...
- Community-acquired pneumonia in childrenKenneth McIntosh
Division of Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
N Engl J Med 346:429-37. 2002
- Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United StatesVladimir Kaplan
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 165:766-72. 2002..The sex differences are of concern and require further investigation...
- Three-year surveillance of community-acquired Staphylococcus aureus infections in childrenSheldon L Kaplan
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Clin Infect Dis 40:1785-91. 2005..Methicillin-resistant Staphylococcus aureus (MRSA) isolates are increasingly frequent causes of skin and soft-tissue infections or invasive infections in many communities...
- Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UKN Woodford
Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London
J Antimicrob Chemother 54:735-43. 2004..e. MICs of cefotaxime > or = 8-fold higher than MICs of ceftazidime. Many were referred as being from community patients. We examined 291 CTX-M-producing isolates from the UK and investigated the genetic basis of their phenotype...
- Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus--an emerging problem for the management of skin and soft tissue infectionsE Anne Eady
School of Biochemistry and Molecular Biology, University of Leeds, UK
Curr Opin Infect Dis 16:103-24. 2003....
- Hospitalized community-acquired pneumonia due to Streptococcus pneumoniae: Has resistance to antibiotics decreased?Xavier Valles
Institut Clinic de Pneumologia i Cirurgia Toracica, Hospital Clinic de Barcelona, Villarroel 170, 08036, Barcelona, Spain
Chest 130:800-6. 2006..Design and setting: We performed a prospective study of all well-defined pneumococcal CAP hospitalizations in the Hospital Clínic de Barcelona (Spain) over 2 years of follow-up, and results were compared with a previous study...
- Early mortality in patients with community-acquired pneumonia: causes and risk factorsC Garcia-Vidal
Infectious Disease Service, Hospital University of Bellvitge, Feixa Llarga s n 08907 L Hospitalet, Barcelona, Spain
Eur Respir J 32:733-9. 2008..Pneumococcal bacteraemia and discordant antibiotic therapy, mainly due to lack of coverage against Pseudomonas aeruginosa are also significant risk factors...
- Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infectionRen Wen Tsay
Division of Infectious Diseases and Tropical Medicine, Tri Service General Hospital, No 325, Section 2, Cheng Kung Road, Neihu, 114 Taipei, Taiwan
Arch Intern Med 162:1021-7. 2002..Although several epidemiological surveys of Klebsiella clinical isolates have been performed, few studies have correlated the clinical isolate with disease...
- Community-acquired pneumonia requiring admission to an intensive care unit: a descriptive studyThomas J Marrie
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Medicine (Baltimore) 86:103-11. 2007..Severe CAP requiring admission to the ICU is common, and the decision about which patients to admit often requires clinical judgment that in many cases appears at odds with various validated pneumonia severity scoring systems...
- Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patientsYves Gillet
Division of Paediatric Intensive Care, Hopital Edouard Herriot, Lyon, France
Lancet 359:753-9. 2002..We aimed to assess the clinical features of these eight cases, and those of other cases identified prospectively, and to compare them with the characteristics of patients with pneumonia caused by PVL-negative strains...
- Extended spectrum beta-lactamases (ESBL) in Escherichia coli and Klebsiella pneumoniae: trends in the hospital and community settingsHusam S Khanfar
Department of Microbiology and Epidemiology, Dhahran Health Centre, Saudi Aramco Company, Eastern Province, Saudi Arabia
J Infect Dev Ctries 3:295-9. 2009..To assess the prevalence of extended spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella strains in nosocomial and community-acquired infections...
- Epidemiology and etiology of community-acquired pneumoniaLionel A Mandell
Division of Infectious Diseases, Department of Medicine, McMaster University, Henderson Site, 711 Concession Street, 40 Wing, 5th Floor, Room 503, Hamilton, ON Canada L8V 1C3
Infect Dis Clin North Am 18:761-76, vii. 2004..This article discusses the epidemiology and bacterial causes of CAP in immunocompetent adults and the severe acute respiratory syndrome coronavirus...
- Risk prediction with procalcitonin and clinical rules in community-acquired pneumoniaDavid T Huang
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Ann Emerg Med 52:48-58.e2. 2008..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65...
- The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumoniaFinlay A McAlister
2E3 24 WMC, University of Alberta Hospital, 8440 112 Street, Edmonton, Alberta, Canada T6G 2R7
Diabetes Care 28:810-5. 2005..To examine whether hyperglycemia at the time of presentation was associated with outcomes in patients admitted to non-intensive care settings with community-acquired pneumonia (CAP)...
- Assessment of pneumonia severity: a European perspectiveS Ewig
Eur Respir J 27:6-8. 2006
- Sepsis severity predicts outcome in community-acquired pneumococcal pneumoniaB Schaaf
Medical Clinic III, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Eur Respir J 30:517-24. 2007..The prediction of survival in the intermediate-risk group might be more accurate with the sepsis score. Pre-hospital antibiotic treatment was associated with less severe disease...
- The changing epidemiology of Staphylococcus aureus?H F Chambers
University of California San Francisco and San Francisco General Hospital, San Francisco, California, USA
Emerg Infect Dis 7:178-82. 2001..aureus decades ago. Even though the origin (hospital or the community) of the emerging MRSA strains is not known, the prevalence of these strains in the community seems likely to increase substantially...
- Prospective comparison of three predictive rules for assessing severity of community-acquired pneumonia in Hong KongShin Yan Man
Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong
Thorax 62:348-53. 2007..Community-acquired pneumonia (CAP) is a leading infectious cause of death throughout the world, including Hong Kong...
- Epidemiology and outcome of nosocomial and community-onset bloodstream infectionD J Diekema
Department of Internal Medicine, Roy J and Lucille A Carver University of Iowa College of Medicine, Iowa City, Iowa, 52242, USA
J Clin Microbiol 41:3655-60. 2003..0001). Although accounting for about half of all bloodstream infections, nosocomial bloodstream infections account for most of the mortality and costs associated with bloodstream infection...
- Methicillin-resistant Staphylococcus aureus disease in three communitiesScott K Fridkin
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 352:1436-44. 2005..Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. The national burden and clinical effect of this novel presentation of MRSA disease are unclear...
- Community-acquired legionella pneumonia in elderly patients: characteristics and outcomeNieves Sopena
Infectious Diseases Unit, Germans Trias i Pujol Hospital Badalona, Autonomous University of Barcelona, Barcelona, Spain
J Am Geriatr Soc 55:114-9. 2007..To compare the risk factors, clinical and laboratory features, and outcome of community-acquired pneumonia (CAP) caused by Legionella pneumophila in elderly (aged > or =65) and younger patients...
- Community-wide outbreaks of clonally related CTX-M-14 beta-lactamase-producing Escherichia coli strains in the Calgary health regionJohann D D Pitout
Division of Microbiology, Calgary Laboratory Services, 9 3535 Research Rd NW, Calgary, Alberta T2L 2K8, Canada
J Clin Microbiol 43:2844-9. 2005..Further studies are warranted to investigate whether community-onset diseases caused by ESBL-producing E. coli are related to a point source or transmission within the community...
- A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgroundsRobert S Daum
Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
J Infect Dis 186:1344-7. 2002..SCCmec type IV is present on the genome of CA-MRSA isolates. Its relatively small size and presence in isolates of diverse genetic backgrounds suggest that it may spread among S. aureus isolates...
- Bacteremia among children admitted to a rural hospital in KenyaJames A Berkley
Centre for Geographic Medicine Research Coast, Kilifi, Kenya
N Engl J Med 352:39-47. 2005..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia...
- Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized studyMarco Confalonieri
Azienda Ospedaliero Universitaria di Trieste, Strada di Fiume 447, 34100 Trieste, Italy
Am J Respir Crit Care Med 171:242-8. 2005..01), MODS score (p = 0.003), and delayed septic shock (p = 0.001). Hydrocortisone treatment was associated with a significant reduction in length of hospital stay (p = 0.03) and mortality (p = 0.009)...
- Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infectionsKristian Kofoed
Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
Crit Care 11:R38. 2007..Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination...
- A new multiplex PCR for easy screening of methicillin-resistant Staphylococcus aureus SCCmec types I-VK Boye
Department of Clinical Microbiology, Hvidovre Hospital, Hvidovre, Denmark
Clin Microbiol Infect 13:725-7. 2007..SCCmec type IV was by far the most common SCCmec type among both hospital- and community-acquired MRSA isolates in Denmark...
- Candida as a risk factor for mortality in peritonitisPhilippe Montravers
Département d Anesthesie Réanimation DAR, CHU Bichat Claude Bernard, AP HP, Universite Paris VII, France
Crit Care Med 34:646-52. 2006..The current study tried to differentiate the pathogenic role of Candida in these two clinical settings and assess its importance on outcome...
- Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind studyRachida el Moussaoui
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
BMJ 332:1355. 2006....
- Genome and virulence determinants of high virulence community-acquired MRSATadashi Baba
Department of Bacteriology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Lancet 359:1819-27. 2002..By contrast with hospital-acquired MRSA, community-acquired MRSA is more susceptible to non b-lactam antibiotics. We investigated the high virulence potential of certain strains of this bacterium...
- Pneumonia in the very oldJean Paul Janssens
Division of Lung Diseases and Department of Geriatrics, Geneva University Hospitals, Geneva, Switzerland
Lancet Infect Dis 4:112-24. 2004....
- Reappraisal of community-acquired bacteremia: a proposal of a new classification for the spectrum of acquisition of bacteremiaYardena Siegman-Igra
Infectious Diseases Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
Clin Infect Dis 34:1431-9. 2002..There is a conceptual and practical need for such a new classification...
- Community acquisition of gentamicin-sensitive methicillin-resistant Staphylococcus aureus in southeast Queensland, AustraliaG R Nimmo
Microbiology Department, Queensland Health Pathology Service, Princess Alexandra Hospital, Woolloongabba 4102, Australia
J Clin Microbiol 38:3926-31. 2000..Community-acquired GS-MRSA strains were not related to nosocomial GR-MRSA or WA-MRSA, but phage typing results suggest that they are related to GS-MRSA previously reported in New Zealand...
- Dissemination of new methicillin-resistant Staphylococcus aureus clones in the communityKeiko Okuma
Department of Bacteriology, Juntendo University, Tokyo, Japan
J Clin Microbiol 40:4289-94. 2002..They multiplied much faster than health-care-associated MRSA and were resistant to fewer non-beta-lactam antibiotics. They seem to have been derived from more diverse S. aureus populations than health-care-associated MRSA strains...
- Risk factors for community-associated methicillin-resistant Staphylococcus aureus skin infections among HIV-positive men who have sex with menNolan E Lee
Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 40:1529-34. 2005..We performed a matched case-control study of 35 case patients and 76 control subjects. CA-MRSA skin infections were associated with high-risk sex and drug-using behaviors and with environmental exposures but not with immune status...
- Emergence of community-associated methicillin-resistant Staphylococcus aureus at a Memphis, Tennessee Children's HospitalSteven C Buckingham
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
Pediatr Infect Dis J 23:619-24. 2004..An epidemiologic investigation was performed because of a perceived increase in infections caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA) among children in the greater Memphis area...
- Procalcitonin kinetics in the prognosis of severe community-acquired pneumoniaNicolas Boussekey
Tourcoing Hospital, Intensive Care and Infectious Disease Unit, 135 rue du Président Coty BP 619, 59208, Tourcoing Cedex, France
Intensive Care Med 32:469-72. 2006..We analyzed the relationship between PCT kinetics and outcome in ICU patients with severe CAP...
- Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive powerHerminia De Lencastre
Laboratory of Microbiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Curr Opin Microbiol 10:428-35. 2007..Then, in the late 1990s, just as effective hygienic and antibiotic use policies managed to bring down the frequency of MRSA in hospitals of several countries, MRSA strains began to show up in the community...
- Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infectionsMark D King
Emory University School of Medicine and Grady Memorial Hospital, Atlanta, Georgia 30303, USA
Ann Intern Med 144:309-17. 2006..Studies have shown that community-acquired methicillin-resistant Staphylococcus aureus (MRSA) causes S. aureus skin and soft-tissue infection in selected populations...
- Bridges from hospitals to the laboratory: genetic portraits of methicillin-resistant Staphylococcus aureus clonesMarta Aires de Sousa
Laboratorio de Genetica Molecular, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Oeiras, Portugal
FEMS Immunol Med Microbiol 40:101-11. 2004..Many questions concerning this extraordinarily versatile and threatening pathogen remain unanswered, needing future investigation..
- Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidinBinh An Diep
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720, USA
J Clin Microbiol 42:2080-4. 2004..0001). There is evidence of clonal replacement over the period from 1999 to 2002, with one of these two clonal groups being supplanted by the other...
- Effects of systemic steroids in patients with severe community-acquired pneumoniaC Garcia-Vidal
Service of Infectious Diseases, pl 12, Hospital Universitari de Bellvitge, c Feixa Llarga s n, 08907 L Hospitalet del Llobregat, Barcelona, Spain
Eur Respir J 30:951-6. 2007..Severity of community-acquired pneumonia remains the most important risk factor associated with increased mortality...
- Clinical features and prognostic factors in adults with bacterial meningitisDiederik van de Beek
Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
N Engl J Med 351:1849-59. 2004..We conducted a nationwide study in the Netherlands to determine clinical features and prognostic factors in adults with community-acquired acute bacterial meningitis...
- Effect of increasing the intensity of implementing pneumonia guidelines: a randomized, controlled trialDonald M Yealy
University of Pittsburgh and the Veterans Affairs Center for Health Equity Research and Promotion, Pittsburgh, Pennsylvania 15240, USA
Ann Intern Med 143:881-94. 2005..Despite the development of evidence-based pneumonia guidelines, limited data exist on the most effective means to implement guideline recommendations into clinical practice...
- Microbiological testing and outcome of patients with severe community-acquired pneumoniaJordi Rello
Critical Care Department, Joan XXIII University Hospital, Tarragona, Spain
Chest 123:174-80. 2003..The study documents the impact of microbiological investigations on therapeutic decisions and outcome in patients with severe community-acquired pneumonia (SCAP)...
- Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumoniaBeat Muller
Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
BMC Infect Dis 7:10. 2007..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
- Type 2 diabetes and pneumonia outcomes: a population-based cohort studyJette B Kornum
Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
Diabetes Care 30:2251-7. 2007..We sought to examine whether type 2 diabetes increases risk of death and complications following pneumonia and to assess the prognostic value of admission hyperglycemia...
- High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infectionsBradley W Frazee
Department of Emergency Medicine, Alameda County Medical Center Highland Campus, Oakland, CA 94602, USA
Ann Emerg Med 45:311-20. 2005....
- Phenotypic prediction rule for community-associated methicillin-resistant Staphylococcus aureusKyle Popovich
Rush University Medical Center, Stroger Hospital of Cook County, 637 S Wood St, Chicago, IL 60612, USA
J Clin Microbiol 45:2293-5. 2007..We assessed the performance characteristics of a rule using the antimicrobial phenotype to predict genotype. This rule could be applied for epidemiologic purposes to describe the trend in CA-MRSA infections over time...
- Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United StatesFred C Tenover
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 44:108-18. 2006..Comparative genomics between USA300-0114 and three other S. aureus lineages (USA100, USA400, and USA500) defined a set of USA300-0114-specific genes, which may facilitate the strain's pathogenesis within diverse environments...
- Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistanceCheol In Kang
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
J Korean Med Sci 21:816-22. 2006..Antimicrobial resistance was a widespread nosocomial problem and also identified in community-acquired infections...
- Community-associated MRSA (CA-MRSA): an emerging pathogen in infective endocarditisB Cherie Millar
Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, Northern Ireland, UK
J Antimicrob Chemother 61:1-7. 2008....
- Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control studyMichael L Jackson
Group Health Center for Health Studies, Seattle, WA 98101 1448, USA
Lancet 372:398-405. 2008..We therefore assessed whether influenza vaccination is associated with a reduced risk of community-acquired pneumonia in immunocompetent elderly people after controlling for health status indicators...
- Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patientsM H Kollef
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
Chest 115:462-74. 1999..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
- Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidinSusan Boyle-Vavra
Department of Pediatrics, Section of Infectious Diseases, University of Chicago, Chicago, IL 60637, USA
Lab Invest 87:3-9. 2007..The second aim is to outline the progress in understanding the role of PVL in CA-MRSA pathogenesis...
- Epidemiology and clinical outcomes of community-acquired pneumonia in adult patients in Asian countries: a prospective study by the Asian network for surveillance of resistant pathogensJae Hoon Song
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Gangnam Gu, Seoul 135 710, South Korea
Int J Antimicrob Agents 31:107-14. 2008..05). The current data provide relevant information about pathogen distribution and antimicrobial resistance of major pathogens of CAP as well as clinical outcomes of illness in Asian countries...
- Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumoniaMarin H Kollef
Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Chest 128:3854-62. 2005..Accumulating evidence suggests that health-care-associated infections are distinct from those that are truly community acquired...
- Guidelines for the selection of anti-infective agents for complicated intra-abdominal infectionsJoseph S Solomkin
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
Clin Infect Dis 37:997-1005. 2003
- Characteristics of patients with healthcare-associated infection due to SCCmec type IV methicillin-resistant Staphylococcus aureusSusan L Davis
Anti Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences and the School of Medicine, Wayne State University, Detroit, MI 48201, USA
Infect Control Hosp Epidemiol 27:1025-31. 2006..The objective of the present study was to characterize the epidemiology of and clinical outcomes associated with SCCmec-IV MRSA infection acquired in the healthcare setting, compared with infection caused by MRSA of other SCCmec types...
- Community-acquired methicillin-resistant Staphylococcus aureus, UruguayXiao Xue Ma
Juntendo University, Tokyo, Japan
Emerg Infect Dis 11:973-6. 2005..The clone was distinct from the highly virulent community clone represented by strain MW2, although both clones carried Panton-Valentine leukocidin gene and cna gene...
- Acute phase reactants and cytokine levels in unilateral community-acquired pneumoniaMustafa Kolsuz
Tuberculosis Control Dispensary, Osmangazi University Medical Faculty, Eskisehir, Turkey
Respiration 70:615-22. 2003..Bacterial infection of the lower respiratory tract initiates an acute inflammatory response. Regulation of the inflammatory response in bacterial pneumonia depends on a complex interaction between immune cells and inflammatory cytokines...
- Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infectionsVictor L Yu
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Emerg Infect Dis 13:986-93. 2007..001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism...
- Diagnostic test for etiologic agents of community-acquired pneumoniaJohn G Bartlett
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21205 2191, USA
Infect Dis Clin North Am 18:809-27. 2004..New tests that merit use in selected patients are the urinary antigen assay for S pneumoniae and the PCR test for L pneumophila. Anticipated developments in the near future are PCR tests for detection of C pneumoniae and M pneumoniae...
- A case-control study of community-associated Clostridium difficile infectionM H Wilcox
Department of Microbiology, Leeds Teaching Hospitals, Old Medical School, Leeds LS1 3EX, UK
J Antimicrob Chemother 62:388-96. 2008..The aim of this study was to determine the incidence of and risk factors for community-associated Clostridium difficile infection (CDI)...
- Testing strategies in the initial management of patients with community-acquired pneumoniaJoshua P Metlay
Veterans Affairs Medical Center and University of Pennsylvania School of Medicine, 9th Floor, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 138:109-18. 2003....
- Body site colonization in patients with community-associated methicillin-resistant Staphylococcus aureus and other types of S. aureus skin infectionsE S Yang
Division of Infectious Diseases and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Clin Microbiol Infect 16:425-31. 2010..aureus infections. The relatively high prevalence of non-nasal colonization may play a key role in CA-MRSA transmission and acquisition of infection...
- Human metapneumovirus as a cause of community-acquired respiratory illnessJoanne Stockton
Public Health Laboratory Service Central Public Health Laboratory, London, United Kingdom
Emerg Infect Dis 8:897-901. 2002..2%) patients. HMPV appears to be associated with community-acquired ARTI. The extent of illness and possible complications related to this new human virus need to be clarified...
- Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureusBinh An Diep
Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, USA
J Infect Dis 193:1495-503. 2006..The extent to which the horizontal transfer of virulence genes has contributed to the emergence of contemporary virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) in hospital and community settings is poorly understood...
- Risk factors of treatment failure in community acquired pneumonia: implications for disease outcomeR Menendez
Servicio de Neumologia, Hospital Universitario La Fe, Valencia, Spain
Thorax 59:960-5. 2004..A study was undertaken to quantify the incidence of failure of empirical treatment in CAP, to identify risk factors for treatment failure, and to determine the implications of treatment failure on the outcome...
- Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapySandra Dial
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, and the Department of Epidemiology and Biostatistics, McGill University, Montreal, Que
CMAJ 175:745-8. 2006..In this study we re-examined a previously reported association between the use of proton pump inhibitors and the development of community-acquired CDAD, this time using an alternative case definition of the disease...
- Severe community-acquired pneumonia: assessment of microbial aetiology as mortality factorF Paganin
Service de Pneumologie et Maladies Infectieuses, Centre Hospitalier Departmental Félix Guyon, GHSR, BP 350, St Pierre, Reunion, France
Eur Respir J 24:779-85. 2004..7) were independent factors related to death. In conclusion, the present study found that the microbial aetiology, Klebsiella pneumoniae, was an independent risk factor for mortality in severe community-acquired pneumonia...
- Staphylococcus aureus community-acquired pneumonia during the 2006 to 2007 influenza seasonAlexander J Kallen
Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Ann Emerg Med 53:358-65. 2009..In response to a number of cases reported to public health authorities in early 2007, additional case reports were solicited nationwide to better define S. aureus community-acquired pneumonia during the 2006 to 2007 influenza season...
- A worldwide perspective of atypical pathogens in community-acquired pneumoniaForest W Arnold
Division of Infectious Diseases, University of Louisville, Louisville, KY 40292, USA
Am J Respir Crit Care Med 175:1086-93. 2007..In different regions of the world, monotherapy with a beta-lactam antimicrobial is common...
- Heterosexual transmission of community-associated methicillin-resistant Staphylococcus aureusHeather A Cook
Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Clin Infect Dis 44:410-3. 2007..This report documents an important and previously unrecognized means of community-associated methicillin-resistant S. aureus colonization and transmission for these potentially invasive strains...
- A randomized trial of influenza vaccination of Hutterite childrenMark Loeb; Fiscal Year: 2006..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
- THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTSLoren Miller; Fiscal Year: 2004....
- Molecular Epidemiology of Community-Associated MRSASANJAY SHUKLA; Fiscal Year: 2008..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
- Impact of statins and ACE inhibitors on outcomes for pneumonia and sepsisEric Mortensen; Fiscal Year: 2009....
- Innate Immunity and exacerbations of COPDSanjay Sethi; Fiscal Year: 2009..The overall goal of this research is to identify specific aspects of the innate defense of the lung that determine the frequency of exacerbations in COPD that will serve as potential therapeutic targets to reduce exacerbations. ..
- REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMAJoseph Solomkin; Fiscal Year: 2004..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
- Functional Senescence of Innate Immunity and PneumoniaKevin High; Fiscal Year: 2003..These data are essential to design meaningful studies using the case-control method, the most effective means of studying the link between immune senescence and infection risk. ..
- ALCOHOL EFFECTS ON THYMIC IMMUNE RESPONSE TO HAARTMaria Jose Miguez; Fiscal Year: 2004..abstract_text> ..
- Impact of Hand Hygiene Guideline on Infections and CostsElaine Larson; Fiscal Year: 2005..abstract_text> ..
- The impact of the pneumococcal conjugate vaccine on pneumonia hospitalizationsCARLOS GRIJALVA; Fiscal Year: 2008..We propose the use of NIS and SID for the evaluation of the pneumococcal conjugate vaccination program, using an innovative approach. [unreadable] [unreadable] [unreadable] [unreadable]..
- Brucella, Aging and Role of IL-17 in Host DefenseKevin High; Fiscal Year: 2005..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
- Heavy Drinking & Coronary Disease: Acute/Chronic EffectsKenneth Mukamal; Fiscal Year: 2006..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
- Staff Hand Hygiene and Nosocomial Infections in NeonatesElaine Larson; Fiscal Year: 2003....
- HOME HYGIENE INTERVENTIONElaine Larson; Fiscal Year: 2002..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
- Stopping URIs and FLU in the Family: the Stuffy TrialElaine Larson; Fiscal Year: 2008....
- HAEMOPHILUS ANTIGEN REGULATION OF INFLAMMATION IN COPDSanjay Sethi; Fiscal Year: 2003..Identification of the integral bacterial and host components that contribute to immune-mediated inflammation in COPD will ultimately lead to novel therapeutic strategies to alter disease progression and improve outcome in COPD. ..
- Interdisciplinary Research:Antimicrobial Resistance(RMI)Elaine Larson; Fiscal Year: 2006..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Jay Mukamal; Fiscal Year: 2010..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- DIETARY FATTY CONTROL OF INFLAMMATIONKevin High; Fiscal Year: 2002..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
- Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB InfectionsLisa Saiman; Fiscal Year: 2009..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
- Antioxidant-based mechanisms used by staphyloccocus aureus to evade host defensesGeorge Y Liu; Fiscal Year: 2010..Significance: The proposed research will address fundamental questions about S. aureus-host interaction, and uncover novel therapeutic approaches toward treatment of S. aureus diseases. ..
- Sixth International Respiratory Syncytial Virus SymposiumANN FALSEY; Fiscal Year: 2007..abstract_text> ..
- Orgin of multidrug resistant uropathogenic E. coliLee Riley; Fiscal Year: 2008..This knowledge should lead to the implementation of improved control of drug-resistant infectious diseases. ..
- Genetic Susceptibility to Mercury-Induced Immune Dysfunction in Autism & ASDEllen Silbergeld; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Device use in Nursing Homes: Reducing Risk of InfectionLona Mody; Fiscal Year: 2007..abstract_text> ..
- MODELING TREATMENT USE & EFFECTIVENESS IN MENTAL ILLNESSSharon Lise Normand; Fiscal Year: 2007..The methodological advances from this research will enable researchers, policy makers, and methodologists to better characterize factors impacting technology innovation/exnovation and to expand the inferences for usual care. ..
- Incident HIV Infection and Immune Response to Hepatitis C VirusAndrea Cox; Fiscal Year: 2007..This, along with excellent mentorship and the supportive and rich environment at JHU, will provide Dr. Cox with the skills she needs to develop into an independent researcher studying HIV/HCV coinfection immunology. ..
- ANALYSIS OF MULTIPLE INFORMANT DATA IN PSYCHIATRYSHARON LISE TERESA NORMAND; Fiscal Year: 2010..These novel and innovative methods will improve the assessment of treatment effects and will contribute to improving the health of the population. ..
- STATISTICAL ISSUES IN AIDS RESEARCHThomas Fleming; Fiscal Year: 2008..Research into optimal designs of Phase HE "Intermediate Trials" of candidate HIV vaccines will also be continued. ..
- WGA Study to Identify Genetic Variants Associated with CV Events in CHSBruce Psaty; Fiscal Year: 2009..The proposed three-part study is efficient, has excellent power to detect small to modest-sized hazard ratios, provides a large sample of WG scans for aim 2, and includes an external replication. (End of Abstract) ..
- Genetic Basis of Virulence of Community MRSA Clone USA300Henry F Chambers; Fiscal Year: 2010..By knocking each of these genes out and testing for loss of virulence, we hope to learn which genes code for virulence. Once these genes are identified, strategies to block their effects may be developed. ..
- Predicting Patient Outcomes from Clinical and Genome-Wide DataGregory F Cooper; Fiscal Year: 2010....
- PATHOGENIC MECHANISMS IN UTIWalter Stamm; Fiscal Year: 2007..Face Page .................................................................................................. 1 B. Description, ..
- Environmental Effects on Lung Function in Cystic Fibrosis PatientsChristopher Goss; Fiscal Year: 2008..Our proposal will also enhance our understanding of lung growth in CF and represents the initial phase of a program to understand environmental effects on CF lung disease. [unreadable] [unreadable] [unreadable]..
- Novel Application of Infection Control Strategies to Limit Transmission of ESBL'SEbbing Lautenbach; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Spread of Community-Acquired MRSA Among Household ContactsRobert S Daum; Fiscal Year: 2010....
- MRSA Colonization and Control in the Cook County Jail - R01Robert Daum; Fiscal Year: 2008..We hope that the Cook County jail will become a model jail for the control of MRSA and other resistant bacteria. [unreadable] [unreadable] [unreadable]..
- Rapid Analysis of Influenza Vaccine EffectivenessEdward Belongia; Fiscal Year: 2007..Interim and annual estimates of VE with 95% confidence intervals will be provided to CDC, including overall VE and VE for each of the priority age groups. ..
- Clinical Impact of Quinolone-Resistant E.coli carriageEbbing Lautenbach; Fiscal Year: 2007..unreadable] [unreadable]..
- CONTROL OF EPIDEMIC INFLUENZAPEDRO PIEDRA; Fiscal Year: 2007..abstract_text> ..
- Trends in and Outcomes of Medication Use in Older AdultsBruce Psaty; Fiscal Year: 2004..abstract_text> ..
- Psychosocial Issues in Umbilical Cord Blood DonationGalen Switzer; Fiscal Year: 2004..abstract_text> ..
- Gordon Research Conference on Staphylococcal DiseasesBRIGITTE BERGER BACHI; Fiscal Year: 2003..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
- Role of Genomic Imprinting in Developmental Neurotoxici*Ellen Silbergeld; Fiscal Year: 2003..2. To utilize high throughput methods to examine patterns of DNA methylation in candidate genes in sperm and zygote in order to detect the presence of male-mediated effects on imprinted genes involved in early development. ..
- IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYAChandy John; Fiscal Year: 2002..falciparum antigens to susceptibility to infection and disease is important in the evaluation of these antigens as malaria vaccine candidates. ..
- MATERNAL HEALTH STATUS AND ADVERSE BIRTH OUTCOMESJennifer Haas; Fiscal Year: 2002..Such interventions should begin from the premise that improved maternal and infant outcomes can only come from improved maternal health. ..
- EFFECTS OF DECISION SUPPORT SYSTEMS ON CLINICAL REASONINGregory Cooper; Fiscal Year: 2001..Under the second aim of our proposed work, we will create and maintain our set of 36 clinical cases as a reusable, calibrated resource for other researchers. ..
- AN EMPIRIC RISK STRATIFICATION RULE FOR HEART FAILUREDONALD YEALY; Fiscal Year: 2001..abstract_text> ..
- MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISMBruce Psaty; Fiscal Year: 2001....
- QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONSEbbing Lautenbach; Fiscal Year: 2004....
- FLAGELLIN GLYCOSYLATION AND VIRULENCE OF P. AEROGINOSAReuben Ramphal; Fiscal Year: 2005..The existence of a central gene product involved in these could prove to be of great significance in controlling virulence. ..
- Genital Ulcer Disease and HIV TransmissionJeanne Sheffield; Fiscal Year: 2005..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
- Impact of Gender on Infected Hospitalized PatientsRobert Sawyer; Fiscal Year: 2006..Data obtained from this research will be used to design interventional studies utilizing hormonal manipulation, i. e., replacement or blockade, to improve outcomes from otherwise lethal infectious diseases. ..
- ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSISLee Riley; Fiscal Year: 2001....
- Alternative endpoints for plague challenge modelsRichard Frothingham; Fiscal Year: 2005..We will use the data generated to refine our hypotheses and to pursue further funding to complete Aim 3. ..
- Duke University Center for Translational ResearchRichard Frothingham; Fiscal Year: 2006....
- Hormone Replacement Therapy and Prothrombotic VariantsBruce Psaty; Fiscal Year: 2005..Power for primary and secondary aims is excellent. Information from this project may help physicians counsel women about HRT to maximize either effectiveness, or safety, or both. ..
- Long-Term Outcomes of NO for Ventilated Premature BabiesDerek Angus; Fiscal Year: 2007..Finally, our data will allow assessment of the robustness of early proxies for subsequent outcomes, key for future study design in this area. ..
- Testosterone Therapy After Hip Fracture in Elderly WomenELLEN BINDER; Fiscal Year: 2005..These data will be used to develop a full-scale proposal to test the long-term hypothesis that testosterone therapy combined with exercise training can improve physical function after a hip fracture. ..
- Improving Antibiotic Use in Acute Care SettingsRalph Gonzales; Fiscal Year: 2006..Specific Aim 2: To evaluate the impact of a rapid diagnostic test for c-reactive protein on antibiotic use for adults with acute cough illness when added to a multidimensional intervention. ..
- CARDIOTOXICITY OF STREPTOCOCCAL PYROGENIC EXOTOXINSPatrick Schlievert; Fiscal Year: 2006....
- Risk factors for drug resistant pneumococcal bacteremiaJoshua Metlay; Fiscal Year: 2009..The proposed study will maintain our enrollment over an additional three years in order to complete six-years of active enrollment and achieve the necessary sample size for the proposed molecular and geographic analyses. ..
- Development, Implementation and Evaluation of Novel Strategies to Reduce InappropJOSHUA P contact METLAY; Fiscal Year: 2010....
- PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUSHenry Chambers; Fiscal Year: 2003..To augment information about where PBPs localize, when they are expressed during the cell cycle will be determined by Northern blotting. ..