Genomes and Genes
Summary: Invasion and multiplication of microorganisms in body tissues, which may be clinically inapparent or result in local cellular injury. A local infection may persist and spread by extension to become an acute, subacute, or chronic clinical infection or disease state. It may also become systemic when the microorganisms gain access to the lymphatic or vascular system. (From Dorland, 27th ed)
Publications276 found, 100 shown here
- Innate immune recognitionCharles A Janeway
Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Annu Rev Immunol 20:197-216. 2002The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors...
- Toll-like receptors and their crosstalk with other innate receptors in infection and immunityTaro Kawai
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
Immunity 34:637-50. 2011..In this review, we will focus on the role played by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition.
- Monocyte recruitment during infection and inflammationChao Shi
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nat Rev Immunol 11:762-74. 2011..The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review...
- International study of the prevalence and outcomes of infection in intensive care unitsJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
JAMA 302:2323-9. 2009b>Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections.
- Mortality after fluid bolus in African children with severe infectionKathryn Maitland
Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
N Engl J Med 364:2483-95. 2011..The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established...
- The global health burden of infection-associated cancers in the year 2002Donald Maxwell Parkin
Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK
Int J Cancer 118:3030-44. 2006..primarily by reviewing the evidence for the strength of the association (relative risk) and the prevalence of infection in different world areas. The estimated total of infection-attributable cancer in the year 2002 is 1...
- Hepcidin and the iron-infection axisHal Drakesmith
Molecular Immunology Group and Medical Research Council MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Science 338:768-72. 2012..We describe how hepcidin integrates signals from diverse physiological inputs, forming a key molecular bridge between iron trafficking and response to infection.
- The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancerJan M Ehrchen
Institute of Immunology, University of Muenster, D 48149 Muenster, Germany
J Leukoc Biol 86:557-66. 2009..Thus, S100A8/S100A9 plays a pivotal role during amplification of inflammation and represents a promising new therapeutic target...
- The CD14+ CD16+ blood monocytes: their role in infection and inflammationLoems Ziegler-Heitbrock
Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
J Leukoc Biol 81:584-92. 2007..The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease...
- Inflammasome activation and IL-1β and IL-18 processing during infectionFrank L van de Veerdonk
Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Trends Immunol 32:110-6. 2011Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses...
- Mucins in the mucosal barrier to infectionS K Linden
Mucosal Diseases Program, Mater Medical Research Institute and The University of Queensland, Level 3 Aubigny Place, Mater Hospitals, South Brisbane, Queensland, Australia
Mucosal Immunol 1:183-97. 2008..Mucosal tissues represent the site of infection or route of access for the majority of viruses, bacteria, yeast, protozoa, and multicellular parasites that ..
- Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infectionBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
JAMA 292:2357-65. 2004..Neonatal infections are frequent complications of extremely low-birth-weight (ELBW) infants receiving intensive care...
- A murine genital-challenge model is a sensitive measure of protective antibodies against human papillomavirus infectionStéphanie Longet
Department of Urology, CHUV, c o IMUL, Bugnon 48, 1011 Lausanne, Switzerland
J Virol 85:13253-9. 2011..is mediated by HPV type-restricted neutralizing antibodies that transudate or exudate at the sites of genital infection. However, a correlate of protection was not established in the clinical trials because few disease cases ..
- HMGB1 is a therapeutic target for sterile inflammation and infectionUlf Andersson
Department of Women s and Children s Health, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Annu Rev Immunol 29:139-62. 2011..Experimental strategies that selectively target HMGB1 and TLR4 effectively reverse and prevent activation of innate immunity and significantly attenuate damage in diverse models of sterile and infection-induced threat.
- Autophagy in infectionVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Curr Opin Cell Biol 22:252-62. 2010..and infectious disease predisposition in human populations; second, demonstration of a role for autophagy in infection control in vivo in animal models; third, the definition of specific antiautophagic defenses in highly evolved ..
- Neutrophil apoptosis and the resolution of infectionAdam D Kennedy
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Immunol Res 43:25-61. 2009..PMNs are typically the first type of leukocyte recruited to sites of infection or areas of inflammation...
- Systemic infection, inflammation and acute ischemic strokeB W McColl
Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
Neuroscience 158:1049-61. 2009..Numerous conditions, including infection and chronic non-infectious diseases, that are established risk factors for stroke are associated with an ..
- Ageing and infectionGaetan Gavazzi
Department of Geriatrics, Geneva University Hospitals, Geneva, Switzerland
Lancet Infect Dis 2:659-66. 2002..features with respect to clinical presentation, laboratory results, microbial epidemiology, treatment, and infection control...
- Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discoveryD Huw Davies
Center for Virus Research, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 102:547-52. 2005..These results verify this platform as a rapid way to comprehensively scan humoral immunity from vaccinated or infected humans and animals...
- Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infectionThierry Roger
Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, Lausanne, Switzerland
Blood 117:1205-17. 2011..of HDAC inhibitors on microbial sensing by macrophages and dendritic cells in vitro and host defenses against infection in vivo...
- The role of inflammation and infection in preterm birthRoberto Romero
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Semin Reprod Med 25:21-39. 2007..Out of all of the suspected causes of preterm labor and delivery, infection and/or inflammation is the only pathological process for which both a firm causal link with preterm birth has ..
- miR-223: infection, inflammation and cancerM Haneklaus
Inflammation Research Group and Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
J Intern Med 274:215-26. 2013Expression of the microRNA miR-223 is deregulated during influenza or hepatitis B infection and in inflammatory bowel disease, type 2 diabetes, leukaemia and lymphoma...
- Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?Adriano Fontana
Institute of Experimental Immunology, University Hospital Zurich, Haeldeliweg 4, CH 8044 Zurich, Switzerland
Brain 133:1300-11. 2010..Moreover the rate of streptococcal infection is increased at onset of narcolepsy...
- The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionAlejandro Villarino
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
Immunity 19:645-55. 2003..demonstrate that WSX-1 is not required for the generation of IFN-gamma-mediated immunity to this parasitic infection and identify a novel function for this receptor as a potent antagonist of T cell-mediated, immune hyperactivity.
- Systemic diseases caused by oral infectionX Li
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
Clin Microbiol Rev 13:547-58. 2000Recently, it has been recognized that oral infection, especially periodontitis, may affect the course and pathogenesis of a number of systemic diseases, such as cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low ..
- Cell death in the host response to infectionK Labbe
Department of Microbiology and Immunology, McGill University, Montreal, Canada H3A 2B4
Cell Death Differ 15:1339-49. 2008..The question of whether cell death performs a physiologic function during infection is key to understanding host-pathogen interactions and pathogenesis, and devising targeted therapeutic ..
- Immunity to infection in IL-17-deficient mice and humansSophie Cypowyj
St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
Eur J Immunol 42:2246-54. 2012....
- How cigarette smoke skews immune responses to promote infection, lung disease and cancerMartin R Stampfli
Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
Nat Rev Immunol 9:377-84. 2009..These adverse effects on the immune system not only occur in active smokers, but also in those exposed to smoke passively in contaminated environments, and may persist for decades after exposure has ended...
- Frequency and risk factors for prevalent, incident, and persistent genital carcinogenic human papillomavirus infection in sexually active women: community based cohort studyPippa Oakeshott
Division of Population Health Sciences, St George s, University of London SW17 0RE, UK
BMJ 344:e4168. 2012..To investigate frequency and risk factors for prevalent, incident, and persistent carcinogenic human papillomavirus (HPV) in young women before the introduction of immunisation against HPV types 16 and 18 for schoolgirls...
- The impact of obesity on the immune response to infectionJ Justin Milner
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Proc Nutr Soc 71:298-306. 2012..This is a review of research findings concerning the impact of obesity on the immune response to infection, including a discussion of possible mechanisms...
- Insights into the role of progranulin in immunity, infection, and inflammationJinlong Jian
Department of Orthopaedic Surgery, New York University Medical Center, New York, New York 10003, USA
J Leukoc Biol 93:199-208. 2013..We then review the data supporting an emerging role of PGRN in the fields of the "Cubic of I", namely, immunity, infection, and inflammation, with special focus on its regulation of autoimmune syndromes...
- Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formationJ Adam Best
Division of Biological Sciences, University of California San Diego, La Jolla, California, USA
Nat Immunol 14:404-12. 2013After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells...
- Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell countsHanifa Bachou
Department of Paediatrics and Child Health, Makerere University Medical School, P O Box 7072, Kampala, Uganda
Nutr J 5:27. 2006The aim of this study was to describe the clinical features, haematological findings and CD4+ and CD8+ cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection.
- Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for ProfJohn M Boyce
Hospital of Saint Raphael, New Haven, Connecticut, USA
MMWR Recomm Rep 51:1-45, quiz CE1-4. 2002..Recommendations concerning related issues (e.g., the use of surgical hand antiseptics, hand lotions or creams, and wearing of artificial fingernails) are also included...
- Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitationsKenneth L Becker
Veterans Affairs Medical Center, Washington, DC, USA
Crit Care Med 36:941-52. 2008..The use of procalcitonin (ProCT) as a marker of several clinical conditions, in particular, systemic inflammation, infection, and sepsis, will be clarified, and its current limitations will be delineated...
- Infection, inflammation, and chronic diseases: consequences of a modern lifestyleStefan Ehlers
Cluster of Excellence Inflammation at Interfaces Borstel Kiel Lübeck Plön, Research Center Borstel, Microbial Inflammation Research, Parkallee 1, D 23845 Borstel, Germany
Trends Immunol 31:184-90. 2010....
- Macrophage phagocytosis of neutrophils at inflammatory/infectious foci: a cooperative mechanism in the control of infection and infectious inflammationManuel T Silva
Instituto de Biologia Molecular e Celular, Porto, Portugal
J Leukoc Biol 89:675-83. 2011..foci accumulates two effects beneficial to the protective host immune response: help in the control of the infection and prevention of neutrophil autolysis, effects that converge to accelerate the resolution of the infection-..
- Th17 cells: from precursors to players in inflammation and infectionAmit Awasthi
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Louis Pasteur Avenue, HIM 780, Boston, MA 02115, USA
Int Immunol 21:489-98. 2009..Here, we review the recent information on differentiation and effector functions of T(h)17 cells during inflammatory conditions...
- Role of acute infection in triggering acute coronary syndromesVicente F Corrales-Medina
Division of Infectious Diseases, Department of Medicine, University of Ottawa, ON, Canada
Lancet Infect Dis 10:83-92. 2010..Greater awareness of this association is likely to encourage research into ways of protecting patients who are at high risk...
- Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicineP D Eckersall
Division of Animal Production and Public Health, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow G61 1QH, UK
Vet J 185:23-7. 2010Acute phase proteins (APPs) have been used as biomarkers of inflammation, infection and trauma for decades in human medicine but have been relatively under-utilised in the context of veterinary medicine...
- Acute ischaemic stroke and infection: recent and emerging conceptsHedley C A Emsley
Division of Neuroscience, The University of Liverpool, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK
Lancet Neurol 7:341-53. 2008The relation between acute ischaemic stroke and infection is complex. Infection appears to be an important trigger that precedes up to a third of ischaemic strokes and can bring about stroke through a range of potential mechanisms...
- Malnutrition and infection: complex mechanisms and global impactsUlrich E Schaible
London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Immunology Unit, London, United Kingdom
PLoS Med 4:e115. 2007
- Neonatal infection and long-term neurodevelopmental outcome in the preterm infantIra Adams-Chapman
Emory University School of Medicine, Department of Pediatrics, Atlanta, Georgia 30322, USA
Curr Opin Infect Dis 19:290-7. 2006The relationship between infection, the inflammatory response and adverse neurodevelopmental outcome in preterm infants is slowly being elucidated...
- Effects of subclinical infection on plasma retinol concentrations and assessment of prevalence of vitamin A deficiency: meta-analysisD I Thurnham
Northern Ireland Centre for Food and Health, Faculty of Life and Health Sciences, University of Ulster, Coleraine, UK
Lancet 362:2052-8. 2003..measurement of plasma retinol concentrations, but because plasma retinol is reduced by clinical and subclinical infection, this proxy measure can lead to overestimation...
- Neutrophils, from marrow to microbesNiels Borregaard
The Granulocyte Research Laboratory, Department of Hematology, National University Hospital Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
Immunity 33:657-70. 2010..Neutrophils circulate in the blood as dormant cells. At sites of infection, endothelial cells capture bypassing neutrophils and guide them through the endothelial cell lining whereby the ..
- Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattleI Martin Sheldon
Institute of Life Science, School of Medicine, Swansea University, Swansea, UK
Biol Reprod 81:1025-32. 2009..b>Infection with Escherichia coli, Arcanobacterium pyogenes, and bovine herpesvirus 4 causes endometrial tissue damage...
- Predictors of infection in rheumatoid arthritisMichele F Doran
Beaumont Hospital, Dublin, Ireland
Arthritis Rheum 46:2294-300. 2002..This study was undertaken to identify predictors of serious infections among patients with RA. Identification of such factors is the necessary first step in reducing the excess risk of infection in RA.
- Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanismsJ L Teeling
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK
Neuroscience 158:1062-73. 2009We have all at some time experienced the non-specific symptoms that arise from being ill following a systemic infection. These symptoms, such as fever, malaise, lethargy and loss of appetite are often referred to as "sickness behavior" ..
- Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic reviewAnn Van den Bruel
Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
Lancet 375:834-45. 2010Our aim was to identify which clinical features have value in confirming or excluding the possibility of serious infection in children presenting to ambulatory care settings in developed countries.
- Effects of prenatal infection on brain development and behavior: a review of findings from animal modelsPatricia Boksa
Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Verdun, Quebec, Canada
Brain Behav Immun 24:881-97. 2010Epidemiological studies with human populations indicate associations between maternal infection during pregnancy and increased risk in offspring for central nervous system (CNS) disorders including schizophrenia, autism and cerebral ..
- Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT™ registryGary R Lichtenstein
Division of Gastroenterology, Hospital of the University of Pennsylvania, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
Am J Gastroenterol 107:1409-22. 2012..The objective of this study was to contribute long-term safety data for infliximab and other therapies in Crohn's disease (CD)...
- Smoking and the outcome of infectionR Huttunen
Department of Internal Medicine, Tampere University Hospital, University of Tampere Medical School, Tampere, Finland
J Intern Med 269:258-69. 2011..Various aspects of the relation between smoking and the outcome of bacterial infection (e.g...
- Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infectionSarah Enouz
Swiss Vaccine Research Institute and Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital CHUV, 1011 Lausanne, Switzerland
J Exp Med 209:1769-79. 2012..Upon activation during an infection they cause autoimmunity and form memory cells...
- Impenetrable barriers or entry portals? The role of cell-cell adhesion during infectionMatteo Bonazzi
Centre Nationale de la Recherche Scientifique, UMR 5236, CPBS, CNRS, 34293 Montpellier, France
J Cell Biol 195:349-58. 2011..The study of all these processes has contributed to the characterization of molecular machineries at the junctions of eukaryotic cells that have been better understood by using pathogens as probes...
- A multilayered defense against infection: combinatorial control of insect immune genesHanna Uvell
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
Trends Genet 23:342-9. 2007..encoding AMPs are expressed at basal levels in barrier epithelia and are upregulated systemically in response to infection. To achieve this differentiated immune defense, Drosophila immune gene promoters combine tissue-specific ..
- Regulatory T cells in infectionRick M Maizels
Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
Adv Immunol 112:73-136. 2011..Treg activity also benefits the host in many circumstances by controlling immunopathogenic reactions to infection. Interestingly, some pathogens are able to directly induce the conversion of naive T cells into suppressive ..
- Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunityMarion Espeli
Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Box 139 Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
Curr Opin Immunol 22:715-22. 2010..the risk of autoimmune disease in both mice and humans, but can also have a profound impact on defence against infection. Using FcγRIIB and FcγRIIIB as examples, we demonstrate that variations associated with increased ..
- Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasisMatthew T Sorbara
Department of Immunology, University of Toronto, Toronto, Ontario, Canada
Immunol Rev 243:40-60. 2011..of peptidoglycan is important in initiating and shaping the immune response under both homeostatic and infection conditions...
- Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infectionDallas Jones
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Clin Invest 121:2534-42. 2011..and discoveries in osteoimmunology are discussed in the context of the diseases bridging these two organ systems, including arthritis, osteoporosis, cancer, and infection, and the targeted treatments used by clinicians to combat them.
- Control of infection by pyroptosis and autophagy: role of TLR and NLRKarina R Bortoluci
Department of Biological Sciences, Federal University of São Paulo Campus Diadema, Rua Arthur Riedel Jardim Eldorado, Diadema, SP, Brazil
Cell Mol Life Sci 67:1643-51. 2010..Data presented here illustrate how the compartmentalization of the innate immune sensors can influence the outcome of infections by controlling the fate of host cells...
- Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signalingJr Wen Shui
La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, San Diego, CA 92037, USA
J Leukoc Biol 89:517-23. 2011..severe mucosal inflammation in the gut and lung, autoimmune-like disease, and impaired immunity during bacterial infection. Here, we will summarize the current view about how HVEM-BTLA signaling is involved in the regulation of mucosal ..
- Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection controlAnselmo Jesus Otero-González
Centro de Estudios de Proteínas, Universidad de La Habana, Havana, Cuba
FASEB J 24:1320-34. 2010..In invertebrates, antimicrobial peptides represent the major humoral defense system against infection, showing a diverse spectrum of action mechanisms, most of them related to plasma membrane disturbance and lethal ..
- Serum lactate as a predictor of mortality in emergency department patients with infectionNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ann Emerg Med 45:524-8. 2005Little is known about risk-stratification biomarkers in emergency department (ED) patients with suspected infection, and lactate is a biologically plausible candidate...
- Alternatively activated macrophages in infection and autoimmunityDelisa Fairweather
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Autoimmun 33:222-30. 2009..Thus, women may be at an increased risk of M2-mediated autoimmunity due to estrogen's ability to increase Th2 responses...
- Choice of fluids for resuscitation in children with severe infection and shock: systematic reviewSamuel Akech
Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Programme, PO Box 230, Kilifi, Kenya
BMJ 341:c4416. 2010To systemically review the evidence from clinical trials comparing the use of crystalloids and colloids for fluid resuscitation in children with severe infection.
- A critical overview of the influence of inflammation and infection on P-glycoprotein expression and activity in the brainDerek J Roberts
Faculty of Medicine, Dalhousie University, 5849 University Avenue, Halifax, N S, B3H 4H7, Canada
Expert Opin Drug Metab Toxicol 4:1245-64. 2008..P-glycoprotein is a blood-brain barrier efflux transporter that limits drug accumulation in the brain...
- The role of infection in the aetiology of inflammatory bowel diseaseRichard Hansen
Gastrointestinal Research Group, Division of Applied Medicine, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, UK
J Gastroenterol 45:266-76. 2010..The possibility that IBD is an infection has been debated since the first description of Crohn's disease...
- Role of blood platelets in infection and inflammationMatthias H F Klinger
Department of Anatomy, University of Lubeck, D 23538 Lubeck, Germany
J Interferon Cytokine Res 22:913-22. 2002..Megakaryopoiesis is inhibited after acute infection with viruses or bacteria. In contrast, chronic inflammation is often associated with reactive thrombocytosis...
- FDG PET of infection and inflammationCharito Love
Division of Nuclear Medicine, Long Island Jewish Medical Center, 270 05 76th Ave, New Hyde Park, NY 11040, USA
Radiographics 25:1357-68. 2005Nuclear medicine plays an important role in the evaluation of infection and inflammation. Fluorine 18 fluorodeoxyglucose (FDG) is a readily available radiotracer that offers rapid, exquisitely sensitive high-resolution tomography...
- Instrumentation in patients with spinal infectionMax C Lee
Department of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA
Neurosurg Focus 17:E7. 2004Placement of instrumentation in the setting of a spinal infection has always been controversial...
- T(14;18) translocation in chronic hepatitis C virus infectionA L Zignego
Department of Internal Medicine, University of Florence, School of Medicine, 50134 Florence, Italy
Hepatology 31:474-9. 2000Pathogenic mechanisms of B-cell lymphoproliferative disorders in chronic hepatitis C virus (HCV) infection are unclear...
- Overwhelming postsplenectomy infection: is quality of patient knowledge enough for prevention?Mohsen Saleh El-Alfy
Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Hematol J 5:77-80. 2004Fulminant, potentially life-threatening infection represents a major long-term risk after splenectomy. This study examines the impact of patient's knowledge and compliance on the prevention of overwhelming postsplenectomy infection (OPSI).
- Distinct innate immune responses to infection and wounding in the C. elegans epidermisNathalie Pujol
Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
Curr Biol 18:481-9. 2008..b>Infection of the nematode Caenorhabditis elegans by the natural fungal pathogen Drechmeria coniospora induces the ..
- Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite developmentJohn H Gilmore
UNC Schizophrenia Research Center, Chapel Hill, NC, USA
Neuropsychopharmacology 29:1221-9. 2004Prenatal exposure to infection increases risk for schizophrenia, and we have hypothesized that inflammatory cytokines, generated in response to maternal infection, alter neuron development and increase risk for schizophrenia...
- Mechanisms of action, physiological effects, and complications of hypothermiaKees H Polderman
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA
Crit Care Med 37:S186-202. 2009..In recent years important insights have been gained into the mechanisms underlying hypothermia's protective effects; in addition, physiological and pathophysiological changes associated with cooling have become better understood...
- Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseasesCarlos G Grijalva
Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave S, Ste 2600, The Village at Vanderbilt, Nashville, TN 37212, USA
JAMA 306:2331-9. 2011..Although tumor necrosis factor (TNF)-α antagonists are increasingly used in place of nonbiologic comparator medications, their safety profile remains incomplete...
- The IL-12 family of cytokines in infection, inflammation and autoimmune disordersKatrina Gee
Department of Microbiology and Immunology, Queen s University, Kingston ON, Canada
Inflamm Allergy Drug Targets 8:40-52. 2009..macrophages, and dendritic cells which produce the members of the IL-12 family of cytokines in response to infection. IL-27 and IL-23 are two cytokines that are related to IL-12; these cytokines share homology at the subunit, ..
- Synergism of nutrition, infection, and immunity: an overviewN S Scrimshaw
Food and Nutrition Programme for Human and Social Development, United Nations University Program Office, Boston, MA 02114 0500, USA
Am J Clin Nutr 66:464S-477S. 1997..of these effects depends on the previous nutritional status of the individual, the nature and duration of the infection, and the diet during the recovery period...
- Vitamin A, infection, and immune functionC B Stephensen
USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, California 95616, USA
Annu Rev Nutr 21:167-92. 2001..Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells...
- The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infectionNathan Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
Ann Emerg Med 48:583-90, 590.e1. 2006....
- Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutritionCaleb E Finch
Davis School of Gerontology and the University of Southern California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 107:1718-24. 2010..These major differences in pathology of aging are discussed in terms of genes that mediate infection, inflammation, and nutrition...
- A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spreadTimo Smieszek
Institute for Environmental Decisions, Natural and Social Science Interface, ETH Zurich, Universitaetsstrasse 22, 8092 Zurich, Switzerland
Theor Biol Med Model 6:25. 2009..In this paper, we show how a mechanistic model of disease transmission differs from this commonly used assumption of a constant per-contact transmission probability...
- γδ-T cells: an unpolished sword in human anti-infection immunityJian Zheng
Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
Cell Mol Immunol 10:50-7. 2013..T cells have both 'innate' and 'adaptive' characteristics in the immune response, and their anti-infection activities are mediated by multiple pathways that are under elaborate regulation by other immune components...
- Serum ferritin levels predict all-cause and infection-cause 1-year mortality in diabetic patients on maintenance hemodialysisChang Chyi Jenq
From the Department of Nephrology, Chang Gung Memorial Hospital, Lin Kou Chang Gung University College of Medicine, Taiwan
Am J Med Sci 337:188-94. 2009..The aim of this study was to assess the relationship between the serum ferritin level and the 1-year outcome in diabetic maintenance hemodialysis (MHD) patients...
- Partial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea pig Chlamydia caviae modelDean W Andrew
Infectious Diseases Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane 4059, Australia
J Reprod Immunol 91:9-16. 2011..There is currently no vaccine to protect against chlamydial infection of the female reproductive tract...
- Early alterations in hippocampal circuitry and theta rhythm generation in a mouse model of prenatal infection: implications for schizophreniaGuillaume Ducharme
Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Montreal, Quebec, Canada
PLoS ONE 7:e29754. 2012..To investigate this, we used a mouse model of prenatal infection with the viral mimic, polyriboinosinic-polyribocytidilic acid (poly I:C), a model based on epidemiological ..
- Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery diseaseJ L Mehta
Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
J Am Coll Cardiol 31:1217-25. 1998..We believe that in certain genetically susceptible people, infection with very common organisms, such as Chlamydia pneumoniae or cytomegalovirus, may lead to a localized infection ..
- Male accessory gland infection and sperm parameters (review)S La Vignera
Section of Endocrinology, Andrology and Internal Medicine and Master in Andrological, Human Reproduction and Biotechnology Sciences, Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy
Int J Androl 34:e330-47. 2011Male accessory gland infection (MAGI) has been identified among those diagnostic categories which have a negative impact on the reproductive function and fertility in males (Rowe et al...
- Tetraspanins: gateways for infectionPeter N Monk
Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, UK
Infect Disord Drug Targets 12:4-17. 2012..viruses, have "hijacked" tetraspanins as a means of entering, traversing and exiting cells during the course of infection. This article reviews current evidence for the role of tetraspanins in the uptake, trafficking and spread of ..
- Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infectionAndrej Trampuz
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Med 117:556-62. 2004..Our aim was to define cutoff values for synovial fluid leukocyte count and neutrophil percentage for differentiating aseptic failure and prosthetic joint infection.
- Tertiary lymphoid organs in infection and autoimmunityKatrijn Neyt
Laboratory of Immunoregulation and Mucosal Immunology, Department for Molecular Biomedical Research, VIB, Ghent, Belgium
Trends Immunol 33:297-305. 2012..Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation...
- Severity of diabetic foot infection and rate of limb salvageDane K Wukich
Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Foot Ankle Int 34:351-8. 2013..in patients with diabetes mellitus (DM), and proper classification of the severity of diabetic foot infection (DFI) is important in determining an effective antibiotic regimen, the need for hospitalization and surgery, and ..
- The agonists of formyl peptide receptors prevent development of severe sepsis after microbial infectionSang Doo Kim
Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea
J Immunol 185:4302-10. 2010..These results suggest that the agonists of formyl peptide receptors effectively prevent development of severe sepsis following microbial infection partly via augmentation of type 1 and type 17 immune responses.
- Endogenous control of immunity against infection: tenascin-C regulates TLR4-mediated inflammation via microRNA-155Anna M Piccinini
Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, 65 Aspenlea Road, London W6 8LH, UK
Cell Rep 2:914-26. 2012..Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection. Here, we show that its expression is required to generate an effective immune response to bacterial ..
- The impact of the current epidemiology of pediatric musculoskeletal infection on evaluation and treatment guidelinesOmar A Gafur
University of Texas Southwestern, Dallas, TX, USA
J Pediatr Orthop 28:777-85. 2008..Staphylococcus aureus is thought to have led to an increase in the incidence of severe musculoskeletal infection in children...
- Improved quality of life, immunoglobulin G levels, and infection rates in patients with primary immunodeficiency diseases during self-treatment with subcutaneous immunoglobulin GMelvin Berger
Medical Affairs Department CSL Behring, King of Prussia, PA, USA
South Med J 103:856-63. 2010..We evaluated the long-term (12-month) experience with home-based self infusions of subcutaneous immune globulin (SCIG) in patients with PIDD on health-related QoL, rates of serious bacterial infections, and all other infections...
- IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizuresAnnamaria Vezzani
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
Brain Behav Immun 25:1281-9. 2011..of innate immune mechanisms and the subsequent inflammatory responses, that are induced in the brain by infection, febrile seizures, neurotrauma, stroke are well documented conditions associated with acute symptomatic seizures ..
- Inflammasome activation: from inflammatory disease to infectionAisling Dunne
School of Biochemistry and Immunology, and School of Medicine, Trinity College Dublin, Dublin 2, Ireland
Biochem Soc Trans 39:669-73. 2011..The present review discusses both aspects of NLR activation and will highlight the role of additional inflammasome complexes in sensing infection.
- Familial and acquired hemophagocytic lymphohistiocytosisG E Janka
Department of Hematology and Oncology, Children s University Hospital, Hamburg, Germany
Annu Rev Med 63:233-46. 2012..Treatment of HLH includes immune-suppressive and immune-modulatory agents, cytostatic drugs, and biological response modifiers. For patients with FHL, stem cell transplantation is indicated and can be curative...
- Two brothers with a microduplication including the MECP2 gene: rapid head growth in infancy and resolution of susceptibility to infectionTrine E Prescott
Departments of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, Ulleval University Hospital, Oslo, Norway
Clin Dysmorphol 18:78-82. 2009..The younger boy had chronic constipation until the age of 3 years. For both boys, the susceptibility to infection subsided in the second year of life...
- The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustionKimberly A Hofmeyer
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Biomed Biotechnol 2011:451694. 2011Cytotoxic CD8 T lymphocytes (CTLs) play a pivotal role in the control of infection. Activated CTLs, however, often lose effector function during chronic infection...
- Reducing Preterm Births in Underserved Pregnant WomenJAMES G CHRISTIAN; Fiscal Year: 2011..If the proposed system proves to be effective in reducing preterm births it can improve maternal and child quality of life as well as reduce the economic burden of preterm births in the U.S. ..
- Menstrual Cycle Control of HIV Infection in the Reproductive TractCHARLES ROBERT WIRA; Fiscal Year: 2013..transmission and to understand how sex hormones modulate FRT HIV target cells to make women more susceptible to infection during the menstrual cycle...
- Multidisciplinary approaches to reproductive health in global health contextXu Qian; Fiscal Year: 2010..It is expected that this effort will help China and other developing countries to respond with increased success to local health challenges and thereby reduce disease burdens globally. ..
- DNase For Prevention Of Reproductive Tract Infections In PregnancyADAM JONATHAN RATNER; Fiscal Year: 2013..If a suitable gel advances to the conclusion of the R33 phase with in vivo efficacy and an acceptable toxicologic profile, we will move forward with the eventual goal of human testing. ..
- Randomized Trial/Reduce Recurrence/Bacterial VaginosisKing Holmes; Fiscal Year: 2004DESCRIPTION: (provided by applicant) Bacterial vaginosis (BV), the most common bacterial vaginal infection in women of reproductive ages, has been linked to female HIV-1 acquisition and infection in both cross sectional and prospective ..
- Oral and Vaginal Microbes, Human Genotype, and Preterm BirthDawn P Misra; Fiscal Year: 2010Preterm birth is a leading cause of infant mortality and morbidity in the U.S. and across the globe. Infection has consistently been identified as an important risk factor for preterm birth...
- Effect of Progesterone Contraceptives on the Vaginal MicrobiomeJASON DANIEL BELL; Fiscal Year: 2013..microbiome is important in maintaining reproductive tract health and provides defense against the acquisition of infection and bacterial colonization...
- A NanoGuard Vaginal Matrix as a Dual-Protection Contraceptive MicrobicideKim A Woodrow; Fiscal Year: 2013....
- Prevention Technologies for Sexual and Reproductive Health ConferenceSusan Ivey; Fiscal Year: 2009..Specific Aim #3. Foster new collaborations by bringing together established practitioners in the field of sexual and reproductive health with product developers and new investigators. ..
- DOUCHING AND REPRODUCTIVE TRACT INFECTIONSEllen Funkhouser; Fiscal Year: 2003..douching practices potentially one of the most distinguishing characteristics of women with and without an infection. Furthermore, the findings will be readily generalizable to a population that historically and currently has ..
- The altered lipid and protein metabolism of pediatric patients with HIV infectionFarook Jahoor; Fiscal Year: 2010..Knowledge gained from this project may lead to new nutritional therapies to help prevent these conditions. ..
- TLR4 as an LPS sendor and susceptibility locusBruce Beutler; Fiscal Year: 2007..In vivo, the Trif Lps2/Lps2 genotype dramatically diminishes sensitivity to LPS, and increases susceptibility to infection by mCMV (and most probably many other viruses) by ablating the type I interferon response...
- Inflammation and Infection as Risk Factors in StrokeMitchell Elkind; Fiscal Year: 2006Serum markers of infection and inflammation have been associated with both incident myocardial infarction (Ml) and prognosis after Ml, but very little data about the relationship of these markers to stroke incidence or prognosis is ..
- Aromatic amino acid metabolism in the pathogenesis of kwashiorkorFarook Jahoor; Fiscal Year: 2008..We also propose that infection-induced synthesis of positive acute phase proteins further limits the availability of AAAs for synthesis of ..
- Forward Genetic Analysis of the Innate Immune Contribution to MCMV ResistanceBruce Beutler; Fiscal Year: 2006..Other germline genetic studies have, to date, implicated only 23 genes in innate resistance to MCMV infection; hence, most of the MCMV "resistome" is still unknown...
- Inflammatory and Infectious Burden and Risk of StrokeMitchell Elkind; Fiscal Year: 2008..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
- Levels of Inflammatory Markers in Treatment of StrokeMitchell Elkind; Fiscal Year: 2008..abstract_text> ..
- Development of furanones for treatment of anthraxMartin Blaser; Fiscal Year: 2005..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
- Role of innate immunity in autoimmune myocarditisNoel Rose; Fiscal Year: 2005..a role in the development of myocarditis, little is understood on how the early, innate immune response to CB3 infection effects the development of autoimmune disease...
- Pseudomonas in Cystic Fibrosis-Regulation of MucoidyVojo Deretic; Fiscal Year: 2006..aeruginosa are nonmucoid, but concomitantly with the establishment of a chronic infection, mucoid mutants overproducing the exopolysaccharide alginate emerge...
- Modulation of EAE with ligand-activated NKT cellsLuc Van Kaer; Fiscal Year: 2005..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
- Cell/Tissue Damage and Autoimmune ResponseNoel Rose; Fiscal Year: 2006..Overall, we anticipate a faculty of 25 to 30 speakers, and about 75 to 100 attendees. After the colloquium, our ultimate goal is to publish the meeting report in a well-circulated journal. ..
- Genetic mechanisms of autoimmune myocarditisNoel Rose; Fiscal Year: 2007..We build on our preliminary data to propose hypothesis-driven aims to identify host genes that control susceptibility and characterize their mechanisms of action in a murine model of autoimmune myocarditis. ..
- HIV/STD Network Prevention Trial in Northern VietnamVivian Go; Fiscal Year: 2005....
- The Regulatory Control Mechanisms of Cross-presentation by Toll-like ReceptorsJULIE MAGARIAN BLANDER; Fiscal Year: 2007..The new knowledge we gain will further the design of therapeutic anti-viral and anti-tumor vaccines, and broaden our understanding of autoimmunity ..
- Autophagy in TuberculosisVOJO P DERETIC; Fiscal Year: 2011..tuberculosis during macrophage infection. Our main hypothesis is that induction of autophagy by pharmacological, physiological, and immunological means ..
- IgA-Antigen Uptake by Peyer's Patch M cellsNICHOLAS MANTIS; Fiscal Year: 2003..The three year KO1 award will provide the applicant with-additional research training and career skills that will greatly facilitate his transition to becoming a successful independent research investigator. ..
- Mechanism of M. tuberculosis Phagosome Maturation ArrestVojo Deretic; Fiscal Year: 2008..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection.
- H PYLORI RECOMBINATION AND GASTRIC COLONIZATIONMartin Blaser; Fiscal Year: 2001..pylori infections. ..
- Hyperacidification and Pseudomonas infections in CFVojo Deretic; Fiscal Year: 2006..A clear connection between the genetic lesion in CF and Pseudomonas infection has not been unequivocally established...
- CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCEMartin Blaser; Fiscal Year: 2004..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
- Cellular Immunity to Chlamydua at the Epithelial InterfaceRAYMOND MORRIS JOHNSON; Fiscal Year: 2010..trachomatis disease has clearly demonstrated that T cells mediate protective immunity against reproductive tract infection. The central hypothesis of the grant is that Chlamydia-specific T cells responsible for sterilizing immunity ..
- Modulation of type I diabetes with NKT cellsLuc Van Kaer; Fiscal Year: 2006..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
- IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONSBARRY ROUSE; Fiscal Year: 2005..Our experiments may identify better methods of generating protective immunity against HSV. ..
- VACCINATION AGAINST HERPES SIMPLEX VIRUSBARRY ROUSE; Fiscal Year: 2004..Our results should be applicable to the future design of vaccines against HSV and may have application to other situations that require immunomodulation. ..
- Immunobiology of ChlamydiaRaymond Johnson; Fiscal Year: 2004..3) To determine the effect of adoptive transfer of mucosal CD8 and CD4 T lymphocytes on the natural course of MoPn genital tract infections. ..
- Sex differences in Coxsackievirus-induced myocarditisNoel Rose; Fiscal Year: 2004..Recently we have examined the role of the innate immune response to CB3 infection on the development of myocarditis and have found significantly increased levels of acute viral and autoimmune ..
- Effects of Dioxin on Vietnamese CiviliansDavid Carpenter; Fiscal Year: 2004..7. ..
- Pathogenesis of Autoimmune MyocarditisNoel Rose; Fiscal Year: 2009..We propose to broaden our knowledge of the pathogenesis of myocarditis, in order to rationalize new biologic approaches to treatment. ..
- Early Life Infection, Neuroinflammation, and MemoryStaci D Bilbo; Fiscal Year: 2010..An estimated 1/3 of pregnancies suffer complications involving infection or trauma of the uterus, fetus, or newborn, and one of the most common consequences of infection or inflammation ..
- Effect of Perinatal Nicotine Exposure on the Development of Autonomic ResponsesJANE ELIZABETH BLOOD SIEGFRIED; Fiscal Year: 2010..Aim 4: Examine specific actions of autonomic response by blocking sympathetic or parasympathetic pathways with pharmacologic agents. ..
- VISION CHANGES IN DIABETESAnthony J Adams; Fiscal Year: 2010..It also aids identification of 'at risk'populations for clinical trials of candidate therapies, which may greatly reduce their cost by decreasing the size of the needed sample and the duration of the trial. ..
- APOE and the Effects of Malnutrition on Cognitive and Intestinal DevelopmentRichard L Guerrant; Fiscal Year: 2010..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
- Critical determinants of CD8+ T-cell-mediated protectionJanko Nikolich Zugich; Fiscal Year: 2009..These issues will be examined in a model of corneal infection with the Herpes simplex virus 1 (HSV-1)...
- Device use in Nursing Homes: Reducing Risk of InfectionLona Mody; Fiscal Year: 2007..primary research interest is epidemiology of nosocomial infections in long-term care and developing effective infection control strategies targeted at reducing these infections with a goal to reduce antimicrobial usage, ..
- Mechanisms of VSV-mediated OncolysisGlen N Barber; Fiscal Year: 2010..Understanding how these pathways function has significant impact on understanding pathogenesis and for developing novel therapeutics and vaccines to combat disease. ..
- Regulation of gamma herpesvirus latency and tumorigenesisHerbert Virgin; Fiscal Year: 2007..latency and tumorigenesis" which funded studies of the mechanisms of y-herpesvirus latency using infection with murine gamma-herpesvirus 68 (gammaHV68) as a model...
- Risk Factrors Associated with CFS and CF PrognosisLEONARD JASON; Fiscal Year: 2007..abstract_text> ..
- B7 RECEPTORS, TUMOR IMMUNOTHERAPY AND IMMUNE REGULATIONYang Liu; Fiscal Year: 2003..More importantly, the proposed studies will provide animal models that can be used to screen monoclonal antibodies that are of therapeutic value for human cancer. ..
- GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSISZoltan Spolarics; Fiscal Year: 2004..abstract_text> ..
- EDUCATION IN PATIENT ORIENTED RESEARCHCharles McCall; Fiscal Year: 2004..The PEPOR of WFUSM will meet the challenge of training talented clinical investigators. ..
- AN EVALUATION OF THE OXFORD HOUSE MODELLEONARD JASON; Fiscal Year: 2004..This study would be the first longitudinal evaluation of Oxford Houses, and it would provide important information on the nature and role of the Oxford House experience on long-term sobriety among recovering alcoholics. ..
- Genetic Polymorphisms in Rheumatoid ArthritisEric Matteson; Fiscal Year: 2004..The mentorship program proposed in this grant is critical to this long-term goal. ..
- B Cell Tolerance Following Allograft TransplantationAnita Chong; Fiscal Year: 2005..These insights could lead to new therapeutic strategies for inducing allograft tolerance and novel assays for the diagnosis of B cell tolerance in the clinic. ..
- Regulation of T cell immunity by indol 2,3 dioxygenaseAndrew Mellor; Fiscal Year: 2006....
- Genes that Mediate Tolerance to the Placental AllograftBruce Beutler; Fiscal Year: 2006..Yet, the maternal immune system remains competent to repel infection or to reject other forms of tissue allograft...
- SLS: Molecular Basis and Role in Invasive GAS DiseaseVictor Nizet; Fiscal Year: 2006..These hypotheses will be tested by molecular genetic studies, attempts protein purification and antibody development, and the use of targeted SLS mutants in in vitro assays of phagocytic function and our in vivo mouse model of GAS NF. ..
- Labeled Bacteriophage for Infection-Specific ImagingMary Rusckowski; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): There is a need for a bacteria-specific infection imaging agent in diagnostic nuclear medicine. At least two agents (Infecton and UBI) are currently under development to meet this need...
- Spleen regulation of beta-cell regenerationAnita Chong; Fiscal Year: 2007..unreadable] [unreadable]..
- T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETIONAndrew Mellor; Fiscal Year: 2002....
- MHC AND GAMMA/DELTA T-CELL RECOGNITIONYueh Hsiu Chien; Fiscal Year: 2007..and (iii) how T10/T22 specific gamma/delta T cells fit into the context of an immune response to Influenza virus infection. A clear understanding of how a useful gamma/delta TCR repertoire is regulated and how the T10/T22 specificity ..
- Autophagy: A Novel Antiviral Host Defense PathwayBeth Levine; Fiscal Year: 2007..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
- Mutagenic analysis of LPS responsesBruce Beutler; Fiscal Year: 2006..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection.
- Akt activation sustains silica induced inflammationCELINE BEAMER; Fiscal Year: 2006..abstract_text> ..
- Infant hearing for modulated tonesBarbara Cone Wesson; Fiscal Year: 2003..This research will also result in methods for assessing threshold sensitivity and sound discrimination in infants that can be applied to those at risk for hearing loss or other auditory dysfunction. ..
- MOLECULAR MECHANISMS OF BONE MARROW INDUCED TOLERANCEJames George; Fiscal Year: 2003..The information generated will provide information regarding the specific cellular and subcellular events that are critical to the induction and maintenance of tolerance in this system. ..
- Molecular Mechanisms in TCR Reactivity to Self LigandsSTEPHEN JAMESON; Fiscal Year: 2005..This has health implications for recovery of the T-cell pool in patients suffering from T lymphopenia due to disease (e.g. AIDS), or therapeutic treatments (such as bone morrow transplant). ..
- A Novel Waveform for Electrical Nerve Conduction BlockKevin L Kilgore; Fiscal Year: 2010..This research will provide a significant tool in our ongoing efforts to reduce disability and improve quality of life. ..
- The Michigan Clinical Research CollaboratoryDaniel Clauw; Fiscal Year: 2004..Disseminate findings, tools, and strategies from this project to other re-engineered networks and Research Centers, and ultimately interface with a National Electronics Clinical Trials and Research (NECTAR) network...
- Dendritic Cell Vaccine in Metastatic Prostate CancerJacques Banchereau; Fiscal Year: 2002..This study will permit us to establish the safety and tolerability of DCs loaded with killed allogeneic tumor cells as a source of TAA. It will also permit us to gain insights into the level of prostate cancer immunity induced by DCs. ..
- Chimeric Yellow Fever/West Nile Virus:Candidate VaccineRafi Ahmed; Fiscal Year: 2003The long-term goal of this project is to develop a safe and effective vaccine against West Nile virus infection. West Nile virus (WNV) has recently attracted considerable attention because of the outbreak in New York City in the summer ..
- NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROMEH Deeg; Fiscal Year: 2003..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..
- SUBPOPULATIONS OF HUMAN DENDRITIC CELLSJacques Banchereau; Fiscal Year: 2008..unreadable] [unreadable]..
- Antigen Presentation Pathway by CD1 MoleculesMitchell Kronenberg; Fiscal Year: 2006..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..