meningitis

Summary

Summary: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (e.g., carcinomatous meningitis), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)

Top Publications

  1. ncbi Idiopathic hypertrophic pachymeningitis
    M J Kupersmith
    Institute of Neurology and Neurosurgery at Beth Israel Medical Center, New York Eye and Ear Infirmary, New York University School of Medicine, New York, NY, USA
    Neurology 62:686-94. 2004
  2. pmc Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis
    Keh Ming Wu
    Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan
    J Bacteriol 191:4492-501. 2009
  3. ncbi The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions
    M Gottschalk
    Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, PO Box 5000, Saint Hyacinthe, Montreal, Quebec, Canada J2S 7C6
    Vet Microbiol 76:259-72. 2000
  4. pmc Neoplastic meningitis from solid tumors: new diagnostic and therapeutic approaches
    Giuseppe Lombardi
    Medical Oncology 1 Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy
    Oncologist 16:1175-88. 2011
  5. pmc Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica
    John F Lindo
    University of the West Indies, Kingston, Jamaica
    Emerg Infect Dis 8:324-6. 2002
  6. pmc Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    BMC Infect Dis 10:67. 2010
  7. doi Eosinophilic meningitis due to Angiostrongylus and Gnathostoma species
    Lynn Ramirez-Avila
    Division of Infectious Diseases, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Clin Infect Dis 48:322-7. 2009
  8. ncbi Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
    Elias Jabbour
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Blood 109:3214-8. 2007
  9. doi Blood-arachnoid barrier disruption in experimental rat meningitis detected using gadolinium-enhancement ratio imaging
    Hiroyuki Ichikawa
    Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co, Ltd, Tokushima 771 0192, Japan
    Brain Res 1390:142-9. 2011
  10. ncbi Naegleria meningitis: a rare survival
    R Jain
    Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Neurol India 50:470-2. 2002

Detail Information

Publications377 found, 100 shown here

  1. ncbi Idiopathic hypertrophic pachymeningitis
    M J Kupersmith
    Institute of Neurology and Neurosurgery at Beth Israel Medical Center, New York Eye and Ear Infirmary, New York University School of Medicine, New York, NY, USA
    Neurology 62:686-94. 2004
    ..Few series of the idiopathic variety have been described, particularly with respect to MRI correlation to clinical outcome and treatment...
  2. pmc Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis
    Keh Ming Wu
    Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan
    J Bacteriol 191:4492-501. 2009
    ..pneumoniae NTUH-K2044, which was isolated from a patient with liver abscess and meningitis, and analyzed differences compared to strain MGH 78578, which was isolated from a patient with pneumonia...
  3. ncbi The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions
    M Gottschalk
    Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, PO Box 5000, Saint Hyacinthe, Montreal, Quebec, Canada J2S 7C6
    Vet Microbiol 76:259-72. 2000
    ..suis serotype 2 virulence factors and the pathogenesis of the meningitis caused by this important bacterial species...
  4. pmc Neoplastic meningitis from solid tumors: new diagnostic and therapeutic approaches
    Giuseppe Lombardi
    Medical Oncology 1 Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy
    Oncologist 16:1175-88. 2011
    Neoplastic meningitis is a result of the spread of malignant cells to the leptomeninges and subarachnoid space and their dissemination within the cerebrospinal fluid...
  5. pmc Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica
    John F Lindo
    University of the West Indies, Kingston, Jamaica
    Emerg Infect Dis 8:324-6. 2002
    After an outbreak in 2000 of eosinophilic meningitis in tourists to Jamaica, we looked for Angiostrongylus cantonensis in rats and snails on the island...
  6. pmc Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    BMC Infect Dis 10:67. 2010
    The presentation and causes of adult meningitis in South Africa have changed substantially as a result of HIV. Knowledge of aetiology and laboratory findings in patients presenting with meningitis are important in guiding management...
  7. doi Eosinophilic meningitis due to Angiostrongylus and Gnathostoma species
    Lynn Ramirez-Avila
    Division of Infectious Diseases, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Clin Infect Dis 48:322-7. 2009
    Eosinophilic meningitis can be the result of noninfectious causes and infectious agents. Among the infectious agents, Angiostrongylus cantonensis and Gnathostoma spinigerum are the most common...
  8. ncbi Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
    Elias Jabbour
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Blood 109:3214-8. 2007
    ..of cytarabine with a prolonged half-life, has been shown to be safe and effective in the treatment of neoplastic meningitis. Liposomal cytarabine was given for CNS prophylaxis to 31 patients with newly diagnosed ALL...
  9. doi Blood-arachnoid barrier disruption in experimental rat meningitis detected using gadolinium-enhancement ratio imaging
    Hiroyuki Ichikawa
    Third Institute of New Drug Discovery, Otsuka Pharmaceutical Co, Ltd, Tokushima 771 0192, Japan
    Brain Res 1390:142-9. 2011
    ..of the central nervous system (CNS) barriers is one of the major pathophysiological consequences of bacterial meningitis. The increase in the permeability of the CNS barriers caused by the disruption is thought to contribute to the ..
  10. ncbi Naegleria meningitis: a rare survival
    R Jain
    Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Neurol India 50:470-2. 2002
    ..An interesting case of naegleria meningitis diagnosed by wet mount cytology of cerebrospinal fluid (CSF) and treated with amphoterecin B, rifampicin and ..
  11. doi Nosocomial ventriculitis and meningitis in neurocritical care patients
    R Beer
    Neurological Critical Care Unit, Dept of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 255:1617-24. 2008
    ..A major complication of this procedure is an EVD-related venticulitis or meningitis. The purpose of this review is (1) to address the magnitude of the problem in the neurocritical care patient ..
  12. ncbi Association of matrix metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis
    H H Lee
    Department of Parasitology, Chung Shan Medical University, 402 Taichung, Taiwan
    Parasitol Res 94:321-8. 2004
    Induction of gelatinase in eosinophilic meningitis of BALB/c-strain mice was caused by Angiostrongylus cantonensis...
  13. ncbi Response of neoplastic meningitis from solid tumors to oral capecitabine
    Pierre Giglio
    Neuro Oncology Department, University of Texas M D Anderson Cancer Center, TX 77030, USA
    J Neurooncol 65:167-72. 2003
    Neoplastic meningitis (NM) is a major challenge for the neuro-oncologist as it constitutes a relatively common clinical problem in systemic and central nervous system cancers, and is very difficult to treat...
  14. ncbi Cerebrospinal fluid cytokine responses in human eosinophilic meningitis associated with angiostrongyliasis
    Pewpan M Intapan
    Department of Parasitology, Faculty of Medicine and Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen 40002, Thailand
    J Neurol Sci 267:17-21. 2008
    ..5 (IL5), IL10, and IL13 in the cerebrospinal fluid (CSF) were markedly higher in 30 patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) than in the controls (P<0.001)...
  15. pmc Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice
    Wen Yuan Du
    Division of Parasitology, Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei Pesticide Toxicology Department, Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Taichung, Taiwan
    Infect Immun 71:3947-53. 2003
    ..with IL-12, however, resulted in low levels of worm recovery and dramatic lessening of the eosinophilic meningitis. A reverse transcriptase PCR assay of mRNA expression in the brain also revealed that the use of IL-12 had ..
  16. pmc The plasmid of Escherichia coli strain S88 (O45:K1:H7) that causes neonatal meningitis is closely related to avian pathogenic E. coli plasmids and is associated with high-level bacteremia in a neonatal rat meningitis model
    Chantal Peigne
    Laboratoire d études de génétique bactérienne dans les infections de l enfant EA 3105, Universite Paris Diderot, Hopital Robert Debre, 75019 Paris, France
    Infect Immun 77:2272-84. 2009
    ..coli neonatal meningitis cases...
  17. pmc Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM)
    A Del Maschio
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Exp Med 190:1351-6. 1999
    ..In this study, we report that BV11 administration was able to attenuate cytokine-induced meningitis in mice...
  18. doi Pathogenetic factors for excessive IgA production: Th2-dominated immune response in canine steroid-responsive meningitis-arteritis
    M Schwartz
    Department of Small Animal Medicine and Surgery, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
    Vet J 187:260-6. 2011
    Canine steroid-responsive meningitis-arteritis (SRMA) is a systemic inflammatory disease with a predominant manifestation within the cervical meninges, increased immunoglobulin A (IgA) levels in serum and cerebrospinal fluid (CSF), and a ..
  19. ncbi Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan
    Hung Chin Tsai
    Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
    Am J Trop Med Hyg 71:222-6. 2004
    The most common cause of eosinophilic meningitis is the rat lungworm Angiostrongylus cantonensis a parasite that is endemic in the southeast Asian and Pacific regions...
  20. ncbi Helminthic eosinophilic meningitis: emerging zoonotic diseases in the South
    James H Diaz
    School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J La State Med Soc 160:333-42. 2008
    ..The most common helminthic infections that can cause eosinophilic meningitis (EoM) in the US, neuroangiostrongyliasis and baylisascariasis, share many of the characteristics of emerging ..
  21. ncbi Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination
    Victoria E Burns
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, England
    Psychosom Med 64:963-70. 2002
    ..This study is the first to examine antibody status after vaccination with a conjugate vaccine, in which a polysaccharide antigen is conjugated to a protein to elicit a thymus-dependent antibody response...
  22. ncbi Eosinophilic meningomyelitis in toxocariasis: case report and review of the literature
    O Eberhardt
    Department of Neurology, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Clin Neurol Neurosurg 107:432-8. 2005
    ..Toxocariasis has to remain among the differential diagnosis in patients with eosinophilic CNS infection even if serological tests in blood are negative. Adult cases seem to be more frequent than previously thought (about 60%)...
  23. ncbi Development of a clinical prediction model for an ordinal outcome: the World Health Organization Multicentre Study of Clinical Signs and Etiological agents of Pneumonia, Sepsis and Meningitis in Young Infants. WHO/ARI Young Infant Multicentre Study Group
    F E Harrell
    Department of Health Evaluation Sciences, University of Virginia, Charlottesville 22908, USA
    Stat Med 17:909-44. 1998
    ..Med. 15, 361-387 (1998)) for survival analysis, adapting it to ordinal logistic regression and further emphasizing penalized maximum likelihood estimation and data reduction...
  24. ncbi Epidemic meningitis, meningococcaemia, and Neisseria meningitidis
    David S Stephens
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Lancet 369:2196-210. 2007
    Meningococcus, an obligate human bacterial pathogen, remains a worldwide and devastating cause of epidemic meningitis and sepsis...
  25. ncbi The first case of Angiostrongylus cantonensis eosinophilic meningitis diagnosed in the city of São Paulo, Brazil
    Maria Cristina Carvalho do Espírito-Santo
    Department of Infectious and Parasitic Diseases, School of Medicine at the University of São Paulo, LIM 06, Sao Paulo, SP, Brazil
    Rev Inst Med Trop Sao Paulo 55:129-32. 2013
    Angiostrongylus cantonensis is a natural parasite found in lung arteries of rats, which in humans may cause eosinophilic meningitis.
  26. ncbi Fatal autochthonous eosinophilic meningitis in a Jamaican child caused by Angiostrongylus cantonensis
    J F Lindo
    Department of Microbiology, The University of the West Indies, Kingston, Jamaica
    Am J Trop Med Hyg 70:425-8. 2004
    ..first reported fatality due to this infection in the Western Hemisphere, and follows shortly after an outbreak of eosinophilic meningitis among a group of travelers to Jamaica. The source of infection in this case could not be determined.
  27. doi Detection of epithelial growth factor receptor mutations in cerebrospinal fluid from patients with lung adenocarcinoma suspected of neoplastic meningitis
    Masato Shingyoji
    Department of Thoracic Disease, Chiba Cancer Center, Chiba, Japan
    J Thorac Oncol 6:1215-20. 2011
    Neoplastic meningitis (NM) is a devastating neurological complication of cancer that needs to be diagnosed in the early stages of disease...
  28. doi Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008)
    M Lowrie
    Division of Companion Animal Sciences, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
    J Vet Intern Med 23:862-70. 2009
    Previous multidrug studies have identified the value of prednisolone in treating steroid responsive meningitis-arteritis (SRMA) and the potential value of acute phase proteins (APPs) and immunoglobulin A (IgA) in diagnosis and monitoring.
  29. ncbi Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases
    H C Tsai
    Department of Medicine, Section of Infectious Diseases, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan
    Am J Med 111:109-14. 2001
    ..SUBJECTS AND METHODS: We performed a retrospective cohort study among Thai laborers with eosinophilic meningitis who ate raw snails (Ampullarium canaliculatus), as well as an environmental surveillance of larvae in snails...
  30. ncbi Eosinophilic meningitis due to Angiostrongylus cantonensis
    C Panackel
    Department of Medicine, Medical College, Kottayam, Kerala 686 575, India
    Indian J Med Microbiol 24:220-1. 2006
    ..We present five cases of eosinophilic meningitis presumably due to infection with Angiostrongylus cantonensis ...
  31. pmc Efficacy of bacteriophage therapy in experimental sepsis and meningitis caused by a clone O25b:H4-ST131 Escherichia coli strain producing CTX-M-15
    Flavie Pouillot
    Universite Paris Diderot, Sorbonne Paris Cité, Equipe d accueil EA3105, and AP HP, Hopital Robert Debre, Paris, France
    Antimicrob Agents Chemother 56:3568-75. 2012
    We evaluated phage therapy in experimental infections due to S242, a fatal neonatal meningitis Escherichia coli strain belonging to the worldwide-distributed O25b:H4-ST131 clone that produces extended-spectrum beta-lactamase CTX-M-15...
  32. ncbi Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis
    S C Lai
    Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien Kuo North Road, Taichung 402, Taiwan
    Ann Trop Med Parasitol 98:715-24. 2004
    ..In the present study, a gelatinase was found to be induced in parasitic meningitis caused, in mice, by Angiostrongylus cantonensis...
  33. ncbi Diagnosis, initial management, and prevention of meningitis
    David M Bamberger
    University of Missouri Kansas City School of Medicine, Kansas City, MO 64108, USA
    Am Fam Physician 82:1491-8. 2010
    Although the annual incidence of bacterial meningitis in the United States is declining, it remains a medical emer- gency with a potential for high morbidity and mortality...
  34. doi Clinical decision rules for evaluating meningitis in children
    Francois Dubos
    Department of Pediatric Emergencies and Infectious Diseases, Roger Salengro Hospital, Lille University Hospital, Lille, France
    Curr Opin Neurol 22:288-93. 2009
    Distinguishing between bacterial and aseptic meningitis in children is sometimes difficult...
  35. doi Concentrations of acute-phase proteins in dogs with steroid responsive meningitis-arteritis
    A Bathen-Noethen
    Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany
    J Vet Intern Med 22:1149-56. 2008
    ..Measurement of concentrations of acute-phase proteins (APPs) is used as an aid in the diagnosis of a variety of diseases in animals...
  36. doi Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema
    Sabrina Hupp
    DFG Membrane Cytoskeleton Interaction Group, Institute of Pharmacology and Toxicology and Rudolf Virchow Center for Experimental Medicine, University of Wurzburg, Versbacherstr 9, 97078 Wurzburg, Germany
    Glia 60:137-46. 2012
    ..Streptococcus pneumoniae, the most common cause of bacterial meningitis, has a high lethality and causes serious disabilities in survivors...
  37. pmc Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis
    Ke Min Chen
    Department of Parasitology, Chung Shan Medical University, 110 Section 1 Chien Kuo North Road, Taichung 402, Taiwan
    Int J Exp Pathol 86:81-9. 2005
    ..The expression of MMP-9 in cerebrospinal fluid (CSF) was significantly increased in mice with eosinophilic meningitis, compared to that in uninfected ones...
  38. doi Chronic and recurrent meningitis
    L Ginsberg
    Department of Neurology, Royal Free Hospital, London, UK
    Pract Neurol 8:348-61. 2008
    Chronic meningitis is defined as the persistence of clinical symptoms and signs of meningitis, with or without abnormal cerebrospinal fluid, for more than four weeks. In as many as one third of cases, no cause is found...
  39. doi Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis
    P C Wei
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Int J Parasitol 41:1175-83. 2011
    The rat lugworm Angiostrongylus cantonensis can cause eosinophilic meningitis. The purpose of this study was to determine whether matrix metalloproteinase (MMP)-12 and its substrate elastin participate in this inflammatory response...
  40. doi Melatonin inhibits microglial activation, reduces pro-inflammatory cytokine levels, and rescues hippocampal neurons of adult rats with acute Klebsiella pneumoniae meningitis
    Un In Wu
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Pineal Res 50:159-70. 2011
    Acute bacterial meningitis caused by Klebsiella pneumoniae (K. pneumoniae) is a major health threat with a high mortality rate and severe neuro-cognitive sequelae...
  41. ncbi The diagnostic accuracy of Kernig's sign, Brudzinski's sign, and nuchal rigidity in adults with suspected meningitis
    Karen E Thomas
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA
    Clin Infect Dis 35:46-52. 2002
    To determine the diagnostic accuracy of Kernig's sign, Brudzinski's sign, and nuchal rigidity for meningitis, 297 adults with suspected meningitis were prospectively evaluated for the presence of these meningeal signs before lumbar ..
  42. pmc Extracellular hsp70 release in canine Steroid Responsive Meningitis-Arteritis
    Sarah A Moore
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L Tharp St, Columbus, OH 43210, USA
    Vet Immunol Immunopathol 145:129-33. 2012
    ..We investigated the presence of ehsp70 in cerebrospinal fluid (CSF) and serum of dogs with Steroid Responsive Meningitis-Arteritis (SRMA), with the hypothesis that an ehsp70 response would occur, and might play a role in the ..
  43. ncbi Carcinomatous meningitis as a clinical manifestation of pancreatic carcinoma
    A F Ferreira Filho
    Chemotherapy Unit, Jules Bordet Institute, Brussels, Belgium
    Ann Oncol 12:1757-9. 2001
    Carcinomatous meningitis (CM) is clinically less common than brain metastasis or spinal cord compression, having dire consequences for both the quality of life and the overall survival of patients with solid tumors...
  44. doi Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis
    Che Chao Chang
    Neurophysiology Laboratory, Neurosurgical Service, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Pineal Res 53:188-97. 2012
    ..In a mouse model of meningitis induced by LPS, melatonin (5mg/kg) or vehicle was intravenously injected at 30min postinsult...
  45. doi Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive meningitis-arteritis in dogs
    M Schwartz
    Department of Small Animal Medicine and Surgery, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
    Vet Immunol Immunopathol 126:248-55. 2008
    Steroid-responsive meningitis-arteritis (SRMA) is a systemic inflammatory disease of juvenile to young adult dogs with a relapsing course and most prominent manifestation in the cervical meninges...
  46. ncbi Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study
    I Cokgor
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Cancer 91:1809-13. 2001
    Even with novel chemotherapeutic agents and external beam radiation therapy, the prognosis of neoplastic meningitis secondary to malignant melanoma is still dismal...
  47. doi Central nervous system infections: meningitis and brain abscess
    Hitoshi Honda
    Division of Infectious Diseases, Washington University of School of Medicine, 660 South Euclid Avenue, Campus Box, 8051 Saint Louis, MO 63110, USA
    Infect Dis Clin North Am 23:609-23. 2009
    Despite advances in antimicrobial and antiviral therapy, meningitis and brain abscess are infections that result in significant morbidity and mortality...
  48. ncbi Multi-immunodot for rapid differential diagnosis of eosinophilic meningitis due to parasitic infections
    P Eamsobhana
    Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Helminthol 80:249-54. 2006
    ..immunosorbent assay (ELISA) was developed for the rapid and simple differential diagnosis of eosinophilic meningitis due to helminth infections...
  49. doi Angiostrongylus cantonensis: effect of combination therapy with albendazole and dexamethasone on Th cytokine gene expression in PBMC from patients with eosinophilic meningitis
    Zongli Diao
    Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Exp Parasitol 123:1-5. 2009
    ..changed cytokine responses in peripheral blood mononuclear cells (PBMC) in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis (EOMA), we measured mRNA levels of Th2 (IL-5, IL-4 and IL-10) and Th1 (IL-..
  50. doi Route of intracerebrospinal fluid chemotherapy administration and efficacy of therapy in neoplastic meningitis
    Michael J Glantz
    Department of Oncology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cancer 116:1947-52. 2010
    ..drug administration influences progression-free survival in the treatment of patients with neoplastic meningitis, which occurs in 1% to 5% of patients with known cancer...
  51. doi Biology and therapy of neoplastic meningitis
    Aaron G Mammoser
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 431, Houston, TX 77030, USA
    Curr Oncol Rep 12:41-9. 2010
    Neoplastic meningitis (NM) occurs in 5% to 8% of cancer patients, commonly as an end-stage process in previously metastatic disease...
  52. pmc Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis
    Marco R Oggioni
    Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita di Siena, Siena, Italy
    Mol Microbiol 61:1196-210. 2006
    ..states were used directly for challenge, sessile cells grown in a biofilm were more effective in inducing meningitis and pneumonia, while planktonic cells from liquid culture were more effective in inducing sepsis...
  53. pmc Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis
    Anja Reiss
    Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Infect Dis 203:393-400. 2011
    Group B Streptococcus (GBS) and Streptococcus pneumoniae (SP) are leading causes of bacterial meningitis in neonates and children...
  54. ncbi Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis
    Jürgen Haas
    Department of Neurology, University of Heidelberg, and Department of Neonatology, Children s Hospital, Germany
    Blood 111:761-6. 2008
    ..Neoplastic meningitis (NM) resulting from leptomeningeal spread of systemic non-Hodgkin lymphoma (NHL) or carcinoma has a poor ..
  55. ncbi Blood-brain barrier dysfunction occurring in mice infected with Angiostrongylus cantonensis
    June Der Lee
    Department of Parasitology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
    Acta Trop 97:204-11. 2006
    ..Dysfunction of the BBB was surmised to be involved in the pathological changes of eosinophilic meningitis caused by the infection of Angiostrongylus cantonensis...
  56. doi Neoplastic meningitis
    Marc C Chamberlain
    Department of Neurology, Division of Neuro Oncology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, University of Washington, Seattle, Washington 98109 1023, USA
    Oncologist 13:967-77. 2008
    Neoplastic meningitis (NM) is a common problem in neuro-oncology, occurring in approximately 5% of all patients with cancer.
  57. pmc Meningitis by Toxocara canis after ingestion of raw ostrich liver
    YOUNG NOH
    Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    J Korean Med Sci 27:1105-8. 2012
    ..He showed symptoms and signs of eosinophilic meningitis with involvement of the lungs and liver...
  58. pmc A case of meningitis due to Achromobacter xylosoxidans denitrificans 60 years after a cranial trauma
    Patrick Manckoundia
    Department of Geriatrics and Internal Medicine, Hospital of Champmaillot, University Hospital, Dijon, France
    Med Sci Monit 17:CS63-5. 2011
    ..It is an opportunistic pathogen and the causative agent of various infections. We report an original case of late posttraumatic meningitis due to AX denitrificans.
  59. ncbi Aetiology of meningitis in HIV-infected patients in a referral hospital in Phnom Penh, Cambodia
    S Chhin
    Preah Bat Norodon Sihanouk Hospital, Phnom Penh, Cambodia
    Int J STD AIDS 15:48-50. 2004
    The HIV epidemic in Cambodia is one of the most extensive in Asia. Meningitis accounts for a substantial proportion of HIV-related morbidity and mortality in Cambodia...
  60. pmc Multilevel intramedullary spinal neurocysticercosis with eosinophilic meningitis
    Amir M Torabi
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, USA
    Arch Neurol 61:770-2. 2004
    ..Cysticercal involvement of the spinal cord is a very rare form of neurocysticercosis. Intramedullary cysts are even less common...
  61. ncbi Eosinophilic meningitis
    Vincent Lo Re
    Division of Infectious Diseases, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med 114:217-23. 2003
    Eosinophilic meningitis is a rare clinical entity that can be useful in narrowing the differential diagnosis of central nervous system disease...
  62. doi Possible intrafamilial transmission of Toxocara causing eosinophilic meningitis in an infant
    Merle Keller
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA
    Pediatr Infect Dis J 27:849-50. 2008
    ..We report a case in an infant resulting in eosinophilic meningitis and prolonged fever...
  63. doi Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the Oka varicella-zoster virus vaccine
    Myron J Levin
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80045 0508, USA
    J Infect Dis 198:1444-7. 2008
    A previously healthy boy who had received varicella vaccine developed herpes zoster with meningitis. The vaccine strain recovered from scabs of 3 skin lesions had the wild-type allele at position 108111, a vaccine marker never previously ..
  64. ncbi Neoplastic meningitis: a rare presentation of bronchial adenocarcinoma
    Emke Maréchal
    Department of Neurology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium
    Acta Neurol Belg 111:337-9. 2011
    Following chronic daily headache, neoplastic meningitis was diagnosed in a non-smoking 44-year-old man. A bronchial adenocarcinoma was found to be the primary tumor. He was treated with erlotinib...
  65. ncbi Corticosteroid treatment of eosinophilic meningitis
    V Chotmongkol
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Clin Infect Dis 31:660-2. 2000
    The role of corticosteroids in the treatment of eosinophilic meningitis has not been definitely established...
  66. ncbi Meningocele with cervical dermoid sinus tract presenting with congenital mirror movement and recurrent meningitis
    Fatih Serhat Erol
    Department of Neurosurgery, Firat University School of Medicine, Norosirurji Anabilim Dali, Elazig, Turkey
    Yonsei Med J 45:568-72. 2004
    ..Besides, to the best of our knowledge, the coexistence of these types of congenital abnormalities with recurrent meningitis, as well as with mirror movement, has never been reported before...
  67. pmc Cost-effective diagnostic checklists for meningitis in resource-limited settings
    Kara N Durski
    School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Acquir Immune Defic Syndr 63:e101-8. 2013
    Checklists can standardize patient care, reduce errors, and improve health outcomes. For meningitis in resource-limited settings, with high patient loads and limited financial resources, central nervous system diagnostic algorithms may be ..
  68. ncbi Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis
    Suthipun Jitpimolmard
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 100:1293-6. 2007
    Eosinophilic meningitis in humans is commonly caused by the nematode Angiostrongylus cantonensis. A severe headache is the most common presenting symptom...
  69. pmc Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infants
    Andi L Shane
    Department of Pediatrics, Emory University School of Medicine, Children s Healthcare of Atlanta, Atlanta, GA 30322, USA
    Pediatrics 129:e914-22. 2012
    Data are limited on the impact of methicillin-resistant Staphylococcus aureus (MRSA) on morbidity and mortality among very low birth weight (VLBW) infants with S aureus (SA) bacteremia and/or meningitis (B/M).
  70. ncbi Quantitative DTI assessment of periventricular white matter changes in neonatal meningitis
    Gyanendra K Malik
    Department of Pediatrics, King George s Medical University, Lucknow, Uttar Pradesh, India
    Brain Dev 30:334-41. 2008
    Neonatal meningitis is one of the important causes of infant mortality and morbidity. Periventricular white matter of neonatal brain is known to be vulnerable to oxidative and hypoxic/ischemic injury secondary to neuro-infections...
  71. ncbi Eosinophilic meningitis caused by Angiostrongylus cantonensis after ingestion of raw frogs
    Chung Hsu Lai
    Department of Infectious Diseases, E Da Hospital I Shou University, Kaohsiung County, Taiwan, Republic of China
    Am J Trop Med Hyg 76:399-402. 2007
    Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis in humans after ingestion of raw or inadequately cooked intermediate hosts or food contaminated with infective third-stage larvae...
  72. doi Imaging of meningitis and ventriculitis
    Suyash Mohan
    Division of Neuroradiology, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuroimaging Clin N Am 22:557-83. 2012
    ..Characteristic findings and recent advances in neuroimaging of meningitis and its complications and ventriculitis are summarized, and certain noninfectious causes of meningitis and ..
  73. doi Expressions of brain-derived neurotrophic factor (BDNF) in cerebrospinal fluid and plasma of children with meningitis and encephalitis/encephalopathy
    Shinichiro Morichi
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Int J Neurosci 123:17-23. 2013
    ..ELISA in most CSF samples from the control group, but were significantly elevated in the patients with bacterial meningitis. The serum BDNF levels were elevated in all subgroups of patients with CNS infections, and the elevation was ..
  74. ncbi Escherichia coli pneumonia in combination with fungal sinusitis and meningitis in a tsunami survivor after the Great East Japan Earthquake
    Ryotaro Igusa
    Department of Respiratory Medicine, Osaki Citizen Hospital, Miyagi, Japan
    Tohoku J Exp Med 227:179-84. 2012
    ..coli) pneumonia in combination with fungal sinusitis and meningitis. A 73-year-old woman survived the tsunami that engulfed the Sanriku coast...
  75. doi The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs
    M Lowrie
    Division of Companion Animal Sciences, Faculty of Veterinary Medicine, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G611QH, UK
    Vet J 182:125-30. 2009
    ..Steroid-responsive meningitis arteritis (SRMA) is a well-recognised inflammatory disease of the dog, the diagnosis of which remains ..
  76. ncbi Successful treatment of carcinomatous meningitis with gefitinib in a patient with lung adenocarcinoma harboring a mutated EGF receptor gene
    Tatsuro Fukuhara
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Tohoku J Exp Med 214:359-63. 2008
    Carcinomatous meningitis is a severe complication of lung cancer...
  77. ncbi Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis
    K M Boje
    Department of Pharmaceutics, School of Pharmacy, University of Buffalo, NY 14260, USA
    Brain Res 720:75-83. 1996
    Increased permeability of the blood-brain (B-B) barrier is observed during meningitis. Preventing B-B barrier alterations is important because adverse neurological outcomes are correlated with breeches in barrier integrity...
  78. doi The changing profile of pediatric meningitis at a referral centre in Cape Town, South Africa
    Nena Katrina Wolzak
    Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
    J Trop Pediatr 58:491-5. 2012
    Pediatric meningitis remains a common cause of childhood morbidity and mortality in developing countries...
  79. ncbi Quality-of-life-adjusted survival comparison of sustained-release cytosine arabinoside versus intrathecal methotrexate for treatment of solid tumor neoplastic meningitis
    Bernard F Cole
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Cancer 97:3053-60. 2003
    The authors compared the quality of life of patients with solid tumor neoplastic meningitis treated in a controlled trial that compared conventional intrathecal methotrexate with a depot cytosine arabinoside liposomal injection (DepoCyt)...
  80. ncbi Neoplastic meningitis
    Beate Gleissner
    Medical Clinic I, University Hospital of Saarland Medical School, Homburg, Saar, Germany
    Lancet Neurol 5:443-52. 2006
    Neoplastic meningitis is a complication of the CNS that occurs in 3-5% of patients with cancer and is characterised by multifocal neurological signs and symptoms...
  81. doi Clinical manifestations of eosinophilic meningitis caused by Angiostrongylus cantonensis: 18 years' experience in a medical center in southern Taiwan
    Yu Ting Tseng
    Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 44:382-9. 2011
    With the improvement of public health, eosinophilic meningitis associated with Angiostrongylus cantonensis infection is now seldom reported in Taiwan. Eosinophilic meningitis typically occurred sporadically in children...
  82. doi Disproportionally strong increase of B cells in inflammatory cerebrospinal fluid of dogs with Steroid-responsive Meningitis-Arteritis
    M Schwartz
    Department of Small Animal Medicine and Surgery, School of Veterinary Medicine Hannover, Hannover, Germany
    Vet Immunol Immunopathol 125:274-83. 2008
    Steroid-responsive Meningitis-Arteritis (SRMA) is a systemic inflammatory disease of juvenile to young adult dogs with a relapsing course and most prominent manifestation in the cervical meninges...
  83. ncbi Primary and opportunistic pathogens associated with meningitis in adults in Bangui, Central African Republic, in relation to human immunodeficiency virus serostatus
    Claudine Bekondi
    Institut Pasteur de Bangui, Unité des Maladies Infectieuses Opportunistes, Boîte Postale 923, Bangui, Central African Republic
    Int J Infect Dis 10:387-95. 2006
    To determine the causative organisms and characteristics of patients presenting with meningitis in Bangui in order to provide guidance to physicians for case management.
  84. ncbi Intrathecal administration of Y-27632, a specific rho-associated kinase inhibitor, for rat neoplastic meningitis
    Hidemitsu Nakagawa
    Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Mol Cancer Res 3:425-33. 2005
    ..To expand therapeutic options for this devastating neoplastic meningitis, we evaluated the potential use of intrathecal Y-27632 administration by employing Walker 256 cells, a rat ..
  85. ncbi Hospital-acquired meningitis in patients undergoing craniotomy: incidence, evolution, and risk factors
    Magaly Cecilia Franchini Reichert
    Federal University of Sao Paulo, Escola Paulista de Medicina, Brazil
    Am J Infect Control 30:158-64. 2002
    To establish the incidence of postcraniotomy meningitis, identify etiologic agents, assess patients' medical progress in relation to both length of hospitalization and mortality, and analyze risk factors.
  86. pmc Clinical aspects of eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis, the rat lungworm
    Gerald S Murphy
    Infectious Disease and Tropical Medicine, Mount Prospect, IL, USA
    Hawaii J Med Public Health 72:35-40. 2013
    Angiostrongylus Eosinophilic Meningitis is caused by human infection with larvae of the rat lungworm, Angiostrongylus cantonensis...
  87. ncbi Spinal paraparesis due to leukemic meningitis in early-stage chronic lymphocytic leukemia
    Martin Schmidt-Hieber
    Medizinische Klinik III, Charite Campus Benjamin Franklin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Leuk Lymphoma 46:619-21. 2005
    Leukemic meningitis is a rare manifestation of chronic lymphocytic leukemia (CLL) and typically occurs in advanced stages. We report the case of a 71-year-old male in whom Binet A, Rai 1 stage CLL was diagnosed in June 2002...
  88. ncbi First case report of Streptococcus suis septicaemia and meningitis from Greece
    E E Mazokopakis
    Eur J Neurol 12:487-9. 2005
  89. ncbi Listeria monocytogenes meningitis in a patient with chronic hepatitis C infection, treated by interferon alfa and ribavirin
    T Vander
    J Infect 46:70-1. 2003
    ..chronic hepatitis C infection without cirrhosis, treated by interferon alfa and ribavirin, who developed listeria monocytogenes meningitis. The possible pathophysiological association is discussed, along with therapeutic implications.
  90. doi Meningitis as a presentation of macroprolactinoma
    J Honegger
    Department of Neurosurgery, University of Tuebingen, Hoppe Seyler Strasse 3, Tuebingen, Germany
    Exp Clin Endocrinol Diabetes 117:361-4. 2009
    Cerebrospinal fluid (CSF) rhinorrhea and consecutive meningitis are well recognised clinical features of macroprolactinomas invading the skull base and are mainly observed under a dopamine-agonist therapy regimen...
  91. ncbi Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole
    Verajit Chotmongkol
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Am J Trop Med Hyg 74:1122-4. 2006
    To study the efficacy of the combination of prednisolone and mebendazole for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis...
  92. ncbi A 1-week course of corticosteroids in the treatment of eosinophilic meningitis
    Kittisak Sawanyawisuth
    Am J Med 117:802-3. 2004
  93. doi Flow cytometry as a diagnostic tool in lymphomatous or leukemic meningitis: ready for prime time?
    Manmeet S Ahluwalia
    Rose Ella Burkhardt Brain Tumor and Neuro Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 441959, USA
    Cancer 118:1747-53. 2012
    In patients with neoplastic meningitis (NM), early diagnosis is highly desirable because the rapid institution of intrathecal therapy may mitigate the course of the disease...
  94. pmc Eosinophilic meningitis attributable to Angiostrongylus cantonensis infection in Hawaii: clinical characteristics and potential exposures
    Natasha S Hochberg
    Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Trop Med Hyg 85:685-90. 2011
    The most common infectious cause of eosinophilic meningitis is Angiostrongylus cantonensis, which is transmitted largely by consumption of snails/slugs...
  95. ncbi Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis
    Sandra Ebert
    Department of Neurology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Neurol Sci 250:50-7. 2006
    ..We have previously shown elevated concentrations of FS in the cerebrospinal fluid (CSF) of patients with meningitis and increased concentrations of activin A in the CSF of rabbits with bacterial meningitis.
  96. ncbi Drug target in eosinophilic meningitis caused by Angiostrongylus cantonensis
    Kittisak Sawanyawisuth
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Infect Disord Drug Targets 10:322-8. 2010
    Eosinophilic meningitis caused by Angiostrongylus cantonensis is an emerging infectious disease. It is the most common form of human angiostrongyliasis...
  97. ncbi Eosinophilic meningitis caused by Angiostrongylus cantonensis associated with eating raw snails: correlation of brain magnetic resonance imaging scans with clinical findings
    Hung Chin Tsai
    Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Am J Trop Med Hyg 68:281-5. 2003
    Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis worldwide. Human infection occurs after ingestion of the worms in raw snails or fish that serve as intermediate hosts...
  98. ncbi Neonatal arterial ischemic stroke and sinovenous thrombosis associated with meningitis
    Karima C Fitzgerald
    Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, 575 West Drive, Indianapolis, IN, USA
    J Child Neurol 22:818-22. 2007
    This series describes 5 neonates with meningitis associated with arterial ischemic stroke or cerebral sinovenous thrombosis identified from a tertiary children's hospital perinatal stroke database...
  99. ncbi Neoplastic meningitis from systemic malignancies: diagnosis, prognosis and treatment
    Kurt A Jaeckle
    Department of Neurology and Oncology, Mayo Clinic Jacksonville, Jacksonsville, FL 32224, USA
    Semin Oncol 33:312-23. 2006
    Long-term survival is occasionally observed in patients with neoplastic meningitis (NM) accompanying breast cancer (13% one-year and 6% 2-year survival), melanoma, and lymphoma, but in general the survival of most patients is short and ..
  100. pmc Molecular diagnosis of eosinophilic meningitis due to Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) by polymerase chain reaction-DNA sequencing of cerebrospinal fluids of patients
    Praphathip Eamsobhana
    Department of Parasitology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
    Mem Inst Oswaldo Cruz 108:116-8. 2013
    ..cantonensis. These results indicate the potential application of this PCR assay with clinical CSF samples for additional support in the confirmation of eosinophilic meningitis due to A. cantonensis.
  101. ncbi Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004)
    Sridharan Gururangan
    The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 12:1540-6. 2006
    ..San Ramon, CA) was conducted in children with neoplastic meningitis following recurrent primary brain tumors to describe toxicities, estimate the maximum tolerated dose (MTD), and ..

Research Grants73

  1. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..In addition, some strains invade the bloodstream, causing bacteremia and meningitis. The mechanisms that H. influenzae uses to negotiate these disparate environments are not well understood...
  2. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..including bacteremia, pneumonia, urinary infection, necrotizing enterocolitis [NEC] plus "NEC scares", and meningitis). All 396 patients recruited into the study (Phase I and Phase II) shall be used to evaluate efficacy of TLF...
  3. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..infections that cause a wide variety of maladies including pneumonia, skin and wound infections, bacteremia and meningitis. In addition, A...
  4. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..urosepsis, septicemia, orchitis, endocarditis, vertebral osteomyelitis, septic arthritis, endophthalmitis, and meningitis n all patients...
  5. Role of Vimentin in Pathogenesis of CNS Inflammation
    Sheng He Huang; Fiscal Year: 2013
    ..in conjunction with its co-receptor PSF, plays an important role in the pathogenesis of neonatal sepsis and meningitis (NSM), which remains a major cause of death in newborns, especially in low-birth weight infants...
  6. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..Cryptococcus neoformans and Cryptococcus gattii frequently infect humans to cause life-threatening pneumonia and meningitis resulting in considerable morbidity and mortality in both immunocompromised and immunocompetent hosts...
  7. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
    ..is currently a leading single cause of neonatal sepsis and the third most frequent over all cause of bacterial meningitis in the United States...
  8. Enterovirus RNA Translation and Replication
    David J Barton; Fiscal Year: 2013
    ..cause a diverse spectrum of human diseases including acute flaccid paralysis (paralytic poliomyelitis), aseptic meningitis, myocarditis, conjunctivitis and fatal systemic infections of neonates...
  9. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): ABSTRACT Aseptic encephalitis and meningitis are potentially fatal diseases defined by acute swelling of the brain or protective membranes covering the brain and spinal cord...
  10. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ..inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis. The current vaccine against the capsule of type b strains is not effective against clinically relevant strains ..
  11. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..As a pathogen, it spreads to the lungs (pneumonia), the central nervous system (meningitis), and the middle ear (otitis media). Mortality and morbidity due to S...
  12. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Meningococcal meningitis and sepsis is a major health problem worldwide...
  13. Identification of vaccine antigens based on expression in blood
    PETER TRIP BEERNINK; Fiscal Year: 2011
    ..To test our hypothesis, we will use Neisseria meningitidis group B (NmB), an important cause of bacterial meningitis and sepsis, for which there is no broadly protective vaccine available...
  14. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..cause urinary tract infections, chorioamnionitis, postpartum wound infection, pyelonephritis, sepsis, and rarely meningitis. While GBS-related morbidity in pregnancy is rarely life- threatening, neonatal infection can be severe and ..
  15. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..pneumoniae is a major causative agent of middle ear infection, bacterial pneumonia, blood infection, and meningitis. The current vaccine and treatment strategies have multiple limitations ranging from the limited vaccine ..
  16. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ..These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  17. Prophage-associated virulence factors in pathogenic Neisseria species
    ANNA KARLS; Fiscal Year: 2009
    ..and pelvic inflammatory disease, and Neisseria meningitidis (meningococci, MC), which causes septicemia and meningitis. The objective of this R03 application is to examine the role of the meningococcal disease-associated (MDA) ..
  18. Molecular Mechanism of cell-cell spread of Listeria in polarized epithelial cells
    KEITH PATRICK IRETON; Fiscal Year: 2013
    ..Listeria monocytogenes is a food-borne, intracellular pathogen that causes gastroenteritis, abortions, or meningitis with a high mortality rate...
  19. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..such as lymphangitis, septic arthritis, osteomyelitis, bacteremia, pneumonia, abscesses of various organs, meningitis, endocarditis, and sepsis. Despite advances in conventional antibiotic therapy, the incidence of S...
  20. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ..These include skin and eye ulcerations (HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  21. Antibody cytokine fusion proteins against Cryptococcus neoformans
    DAVID OWEN BEENHOUWER; Fiscal Year: 2012
    ..Host immune responses will be defined and correlated with efficacy. Mortality from cryptococcal meningitis is 10-20% indicating the need for better therapies...
  22. Vaccine Immunotoxin and Radioimmunotherapy of Primary and Metastatic CNS Tumors
    Darell D Bigner; Fiscal Year: 2013
    ..for treatment of two of the conditions in neuro-oncology which are most refractory to treatment, neoplastic meningitis (NM) and glioblastoma multiforme (GBM)...
  23. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis. The current vaccine against the capsule of type b strains is not effective against clinically relevant strains ..
  24. Characterization of the La Crosse Virus glycoprotein fusion peptide
    SAMANTHA STANDISH SOLDAN; Fiscal Year: 2012
    ..virus (LACV), a NIAID Category B priority pathogen, is a common cause of pediatric encephalitis and aseptic meningitis in areas of the Midwestern United States where its principal mosquito vector, Ochlerotatus (formerly Aedes) ..
  25. Scale-Up from Pilot To High-Throughput Screen for Inhibitors of Aquaporin-4
    Marc F Pelletier; Fiscal Year: 2011
    ..or brain swelling) is a major contributor to the damage caused by stroke, traumatic brain injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leading cause of disability...
  26. Toxoid adjuvant CRM197 production in a stable reduced genome E. coli strain
    Frederick R Blattner; Fiscal Year: 2012
    ..the adjuvant portion in conjugate vaccines currently used to protect infants and children against bacterial meningitis. CRM197 is difficult to manufacture in quantity and therefore very expensive...
  27. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ..These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  28. The Abeta protein of Alzheimer's Disease is an antimicrobial peptide
    Robert D Moir; Fiscal Year: 2013
    ..phase of our proposed study experiments will test if APP knockout mice have reduced resistance to bacterial meningitis. Conversely, transgenic mice over-expressing A[unreadable] in the CNS will be tested for increased resistance to ..
  29. An engineered meningococcal OMV vaccine for Africa against all capsular groups
    Dan M Granoff; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Meningococci cause explosive epidemics of meningitis in sub-Sahara Africa that can involve more than 100,000 cases in a few months...
  30. Lyme neuroborreliosis pathogenesis in the rhesus monkey
    MARIO TOMAS PHILIPP; Fiscal Year: 2013
    ..We have further determined, in rhesus macaques with Lyme meningitis due to intrathecal B...
  31. Regulation of the Poly Sialic Virulence Factor
    ERIC ROSS VIMR; Fiscal Year: 2013
    ..as two major virulence factors responsible for making these strains the leading causes of neonatal bacterial meningitis. Using microbial genetics and innovative methods of carbohydrate analysis, we defined the complete pathways for ..
  32. Targeting copper homeostasis in the fungal pathogen, Cryptococcus neoformans
    RICHARD FESTA; Fiscal Year: 2013
    ..progress to systemic infection in both immunocompromised and healthy individuals, leading to lethal cryptococcal meningitis. Current therapies to address C...
  33. Novel Antifungal Therapeutic Approaches
    Joseph Heitman; Fiscal Year: 2012
    ..in AIDS patients who fail or do not receive HAART, and Cryptococcus neoformans, the leading cause of fungal meningitis in the world due to the AIDS epidemic...
  34. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..These include skin and eye ulcerations (HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  35. Coordinate regulation of competence and pneumocin production in S. pneumoniae
    SUZANNE RACHEL DAWID; Fiscal Year: 2013
    ..Streptococcus pneumoniae (pneumococcus) is an important human pathogen and the most common cause of bacterial meningitis, pneumonia and otitis media...
  36. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
    ..coli (ExPEC) strains, including urinary tract infections (UTIs), newborn meningitis (NBM), abdominal sepsis, and septicemia, result in significant morbidity, mortality and are estimated to cost ..
  37. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Rod Zalutsky; Fiscal Year: 2013
    ..and 211At-labeled anti-EGFRvIII conjugates in athymic rodents with subcutaneous, intracranial, and neoplastic meningitis xenografts;and 5) With the best radio labeled anti-EGFRvIII conjugates, conduct all the toxicity, efficacy, ..
  38. Rapid, automated, detection of viral and bacterial pathogens causing meningitis
    Andrew Hemmert; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Meningitis and encephalitis are inflammatory, often infectious, processes of the central nervous system that can result in significant morbidity and mortality...
  39. LISTERIA AND SHIGELLA USE ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The gram positive bacillus Listeria monocytogenes causes bacteremia and meningitis, while the gram negative bacillus Shigella flexneri causes severe diarrhea and dehydration...
  40. Synthetic saccharides to study immunological properties of Streptococcus pneumoni
    Alexei V Demchenko; Fiscal Year: 2010
    ..Streptococcus pneumoniae (SPn) have become one of the most frequent causes of pneumonia, bacteremia, and meningitis in the elderly, immunocompromised, and especially in young children...
  41. Intercellular trafficking of labeled aminoglycosides in living hair cells
    Dale Warren Hailey; Fiscal Year: 2013
    ..Reducing hair cell death caused by aminoglycoside antibiotics would allow us to better treat tuberculosis, meningitis, cystic fibrosis, and a range of systemic infections (Cheng et al., 2009;Lima et al., 2006;Yeat et al., 1997)...
  42. Deciphering ExPEC Virulence Mechanisms
    Matthew A Mulvey; Fiscal Year: 2012
    ..coli (ExPEC) cause a diverse array of diseases including urinary tract infections, sepsis, and neonatal meningitis. These infections affect 6.7 to 8.6 million individuals each year in the United States, at a cost of $1.5 to $2...
  43. Bifunctional antibodies with targeted CNS delivery against West Nile virus
    Qiang Chen; Fiscal Year: 2013
    ..Humans infected with WNV can develop meningitis and encephalitis, and the elderly and immunocompromised are at greatest risk for severe neurological disease and ..
  44. Mechanisms of pneumococcal persistence during carriage.
    JEFFREY NEAL WEISER; Fiscal Year: 2013
    ..species accounts for a large proportion of respiratory tract (pneumonia, otitis media) and invasive (sepsis, meningitis) bacterial diseases...
  45. Pathogenesis of Cryptococcus Spores
    Christina M Hull; Fiscal Year: 2013
    ..The meningitis-causing fungus C...
  46. Effect of alcohol exposure on human Treg induction &CD36HI monocyte biology
    KATHLEEN ELIZABETH JAEGER; Fiscal Year: 2013
    ..FAS children have an increased incidence of bacterial infections including, but not limited to, meningitis, pneumonia and sepsis, as well as increased viral infections caused by agents such as cytomegalovirus and ..
  47. Maneuvering of Macrophage Function By Escherichia coli K1
    PRASADARAO V NEMANI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacterial meningitis due to Escherichia coli K1 is a serious illness of the central nervous system. It is the most common pathogen causing meningitis in premature infants (46%)...
  48. CYTOKINE INFLAMMATORY MEDIATORS AND MUCIN REGULATION IN MIDDLE EAR EPITHELIUM
    Joseph E Kerschner; Fiscal Year: 2013
    ..for surgical procedures in young children [4,7-8], and is associated with life-threatening complications such as meningitis and brain abscess formation [9- 10]...
  49. Grafting DNA Codes on Paper for Rapid, Low-Cost, and Sensitive Meningitis Diagnos
    Xiujun Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacterial meningitis is a severe bacterial infection of the protective brain membranes and can become fatal in as early as 24 hours after symptoms are noticed...
  50. Chemical-genetic functional annotation of the genome of a meningitis pathogen
    Hiten D Madhani; Fiscal Year: 2013
    ..This opportunistic encapsulated budding yeast is the most common cause of fungal meningitis. Annually, there are estimated 1,000,000 cases that result in ~600,000 deaths, and one-third of deaths in AIDS ..
  51. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..signal transduction cascade that controls virulence of Cryptococcus neoformans, the leading cause of fungal meningitis. The central element of this virulence pathway is the calcium-calmodulin activated protein phosphatase ..
  52. BIOACTIVITIES OF PNEUMOCOCCAL CELL WALL IN MENINGITIS
    Elaine I Tuomanen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The pneumococcus remains the cause of meningitis with the greatest morbidity and mortality...
  53. Cryptococcus neoformans Gene Knockout Resource
    Hiten D Madhani; Fiscal Year: 2013
    ..Cryptococcus neoformans is an encapsulated budding yeast that is the most common cause of fungal meningitis. There are an estimated 1,000,000 cases that result in ~600,000 deaths each year...
  54. The immunopathogenesis of HIV-related Immune Reconstitution Inflammatory Syndrome
    DAVID BISAGAYA MEYA; Fiscal Year: 2013
    ..to diagnose and predict HIV immune reconstitution inflammatory syndrome (IRIS) associated with cryptococcal meningitis (CM) in AIDS patients at the Infectious Diseases Institute (IDI) in Kampala, Uganda and to better understand the ..
  55. Role of the Listeria protein InlC and its host ligand Tuba in cell-cell spread
    KEITH PATRICK IRETON; Fiscal Year: 2009
    ..applicant): Listeria monocytogenes is a food-borne, intracellular pathogen capable of causing gastroenteritis, meningitis, and abortions...
  56. ESCHERICHIA COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Sheng He Huang; Fiscal Year: 2009
    Despite the availability of antibiotics over the last sixty years, neonatal sepsis and meningitis (NSM) remains a major cause of death in newborns. E. coli is the most common gram-negative bacteria causing NSM...
  57. Refinement of lead compounds to modulate water permeability through AQP4
    Marc F Pelletier; Fiscal Year: 2012
    ..contributor to the damage caused by stroke, traumatic brain injury, traumatic spinal-cord injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leading cause of disability...
  58. The CryptoART Study: Decreasing mortality associated with initiation of antiretro
    CHIRATIDZO ELLEN NDHLOVU; Fiscal Year: 2013
    ..We also propose to develop a meningitis risk score that can be used by remote facilities to identify among patients with a positive LFA test which ..
  59. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
    ..1R01 AI075298-01A2 Viruses can induce a variety of disease states in the central nervous system. Meningitis is a potentially fatal disorder induced by a long list of human pathogens, including viruses, and is often ..
  60. Invasion of C. neoformans into brain endothelial cells
    Ambrose Y Jong; Fiscal Year: 2012
    Pathogenic yeast Cryptococcus neoformans can disseminate through the blood stream and cause devastating meningitis. At present, cryptococcal meningitis is the most common fungal infection of the central nervous system (CNS) and also the ..
  61. Streptococcus pneumoniae genetic competence and pathogenesis
    Michael E Sebert; Fiscal Year: 2011
    ..known as the pneumococcus, is a bacterial pathogen that causes a range of human diseases including pneumonia, meningitis and bloodstream infections...
  62. MtaR-regulated virulence in Streptococcus agalactiae
    Daniel Shelver; Fiscal Year: 2009
    ..agalactiae (group B Streptococcus;GBS) is a leading cause of invasive infections such as pneumonia, sepsis, and meningitis in neonates. GBS is also an emerging cause of disease among the immunocompromised and elderly...
  63. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    ..mice inoculated systemically with the RF spirochete Borrelia turicatae develop relapsing spirochetemia with mild meningitis and residual brain infection but without brain injury...
  64. Amphotericin B Analogs
    Charles Hutchinson; Fiscal Year: 2009
    ..to be an important drug for invasive aspergillosis, candidemia, mucormycosis, fusariosis and Cryptococcosis meningitis because of its potency, broad spectrum of activity and the low incidence of drug resistance associated with its ..
  65. Nicotine & Immunopathogenesis of Cryptococcal meningitis
    Mohan Sopori; Fiscal Year: 2007
    ..abstract_text> ..
  66. Antifungal Drug Susceptibility of Cryptococcus neoformans
    Robert Larsen; Fiscal Year: 2009
    ..In the developing world cryptococcal meningitis and pulmonary tuberculosis are the two most common opportunistic infections...
  67. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    Cryptococcus neoformans (C. neoformans) is an encapsulated yeast mainly responsible for meningitis/meningocephalitis in patients infected with HIV. For areas of the world where HIV is endemic, C...
  68. H. INFLUENZAE: PENICILLIN BINDING PROTEINS & CELL WALL
    Paul Mendelman; Fiscal Year: 1991
    H. influenzae is an important pathogen. Approximately 10,000 infants acquire meningitis each year due to the type b organism with 500 deaths and neurologic sequelae in 50% of the survivors. In addition, montypable H...
  69. MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIA
    Milton Saier; Fiscal Year: 2000
    ..coli and Salmonella species are principal causative agents of diarrhea, dysentery, urinary tract infections, meningitis in children, septicemia, enteric fevers, an pneumonia...
  70. E COLI TRANSLOCATION ACROSS INTESTINAL EPITHELIUM
    Michelle Pietzak; Fiscal Year: 2003
    ..Dr. Kim is a prominent researcher in the field of the pathogenesis of E. coli meningitis, having (a) established the virulence roles for the K1 capsular polysaccharide, outer membrane protein A, and S ..
  71. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    Aminoglycosides are clinically essential for treating life-threatening Gram-negative bacterial infections, e.g., meningitis, and in preventing infection in burns and premature babies...
  72. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2009
    ..malaria'is a clinical syndrome consisting of coma not attributable to convulsions, hypoglycemia, or meningitis in patients with P. falciparum parasitemia...
  73. SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATION
    Barnett Nathan; Fiscal Year: 2003
    ..Nitric oxide (NO) is known to play a role in bacterial meningitis and also has immunomodulatory and vasoactive properties...