limbic encephalitis

Summary

Summary: A paraneoplastic syndrome marked by degeneration of neurons in the medial temporal lobe. Clinical features include behavioral changes, HALLUCINATIONS, loss of short term memory, anosmia, AGEUSIA, and DEMENTIA. Circulating anti-neuronal antibodies (anti-Hu; also called ANNA 1) and small cell lung carcinomas are frequently associated with this condition. (From Pathologe 1997 Sep;18(5):406-10; J Int Neuropsychol Soc 1996 Sep;2(5):460-6; Brain 1997 Jun;120(Pt 6):923-8)

Top Publications

  1. pmc Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
    Beau M Ances
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:1764-77. 2005
  2. pmc Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
    Sarosh R Irani
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 133:2734-48. 2010
  3. ncbi Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Brain 127:701-12. 2004
  4. pmc Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series
    Meizan Lai
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:776-85. 2010
  5. pmc AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location
    Meizan Lai
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 65:424-34. 2009
  6. pmc GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders
    A Boronat
    Servei de Neurologia, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Neurology 76:795-800. 2011
  7. ncbi Limbic encephalitis - a review
    N E Anderson
    Neurology Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand
    J Clin Neurosci 15:961-71. 2008
  8. ncbi Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis
    Michael P Malter
    Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
    Ann Neurol 67:470-8. 2010
  9. ncbi Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis
    Sarosh R Irani
    Department of Clinical Neurology, Oxford University, Oxford, UK
    Ann Neurol 69:892-900. 2011
  10. pmc Binding deficits in memory following medial temporal lobe damage in patients with voltage-gated potassium channel complex antibody-associated limbic encephalitis
    Yoni Pertzov
    Institute of Neurology, University College London, London, UK
    Brain 136:2474-85. 2013

Detail Information

Publications231 found, 100 shown here

  1. pmc Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
    Beau M Ances
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:1764-77. 2005
    We report seven patients, six from a single institution, who developed subacute limbic encephalitis initially considered of uncertain aetiology. Four patients presented with symptoms of hippocampal dysfunction (i.e...
  2. pmc Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
    Sarosh R Irani
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 133:2734-48. 2010
    ..from mammalian brain tissue have been identified in patients with neuromyotonia, Morvan's syndrome, limbic encephalitis and a few cases of adult-onset epilepsy...
  3. ncbi Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Brain 127:701-12. 2004
    ..Amongst the differential diagnoses, herpes simplex encephalitis, Korsakoff's syndrome and limbic encephalitis should be considered...
  4. pmc Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series
    Meizan Lai
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:776-85. 2010
    Voltage-gated potassium channels are thought to be the target of antibodies associated with limbic encephalitis. However, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we aimed to identify ..
  5. pmc AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location
    Meizan Lai
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 65:424-34. 2009
    To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures.
  6. pmc GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders
    A Boronat
    Servei de Neurologia, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Neurology 76:795-800. 2011
    Aminobutyric acid-B receptor antibodies (GABA(B)R-ab) were recently described in 15 patients with limbic encephalitis (LE), associated with small-cell lung cancer (SCLC) or with concurrent glutamic acid decarboxylase (GAD) antibodies...
  7. ncbi Limbic encephalitis - a review
    N E Anderson
    Neurology Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand
    J Clin Neurosci 15:961-71. 2008
    The clinical features of limbic encephalitis are diverse and early diagnosis of the disorder is frequently difficult. Four patients with limbic encephalitis are described...
  8. ncbi Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis
    Michael P Malter
    Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
    Ann Neurol 67:470-8. 2010
    ..decarboxylase (GAD) have been described in a few patients with temporal lobe epilepsies consistent with limbic encephalitis (LE)...
  9. ncbi Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis
    Sarosh R Irani
    Department of Clinical Neurology, Oxford University, Oxford, UK
    Ann Neurol 69:892-900. 2011
    To describe a distinctive seizure semiology that closely associates with voltage-gated potassium channel (VGKC)-complex/Lgi1 antibodies and commonly precedes the onset of limbic encephalitis (LE).
  10. pmc Binding deficits in memory following medial temporal lobe damage in patients with voltage-gated potassium channel complex antibody-associated limbic encephalitis
    Yoni Pertzov
    Institute of Neurology, University College London, London, UK
    Brain 136:2474-85. 2013
    ..Voltage-gated potassium channel complex antibody-associated limbic encephalitis has recently been recognized as a form of treatable autoimmune encephalitis, frequently associated with ..
  11. pmc Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
    Eric Lancaster
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:67-76. 2010
    ..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
  12. ncbi Limbic encephalitis in children and adolescents
    E Haberlandt
    Medical University of Innsbruck, Clinical Department of Pediatrics IV, Division of Neuropediatrics and Inherited Metabolic Diseases, Innsbruck, Austria
    Arch Dis Child 96:186-91. 2011
    b>Limbic encephalitis is rare in people <18 years of age and rarely given a formal diagnosis.
  13. ncbi Clinical, magnetic resonance imaging, and electroencephalographic findings in paraneoplastic limbic encephalitis
    Nicholas D Lawn
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:1363-8. 2003
    To analyze clinical presentation of and paraclinical test abnormalities in patients with paraneoplastic limbic encephalitis (PLE).
  14. ncbi Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 44:149-53. 2008
    Recently, non-herpetic acute limbic encephalitis (NHALE) was identified as a new subgroup of limbic encephalitis. The immunological pathophysiology of NHALE is still unclear.
  15. ncbi Balloon cells in the dentate gyrus in hippocampal sclerosis associated with non-herpetic acute limbic encephalitis
    Hiroaki Miyahara
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
    Seizure 20:87-9. 2011
    ..a 32-year-old woman with mesial temporal lobe epilepsy and a precipitating history of non-herpetic acute limbic encephalitis. Histologically, the resected specimen showed features of hippocampal sclerosis with granule cell ..
  16. ncbi Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical review
    Tareq Braik
    Department of Medicine, John H Stroger, Jr Hospital of Cook County, Chicago, IL, USA
    Am J Med Sci 340:301-8. 2010
    ..Paraneoplastic neurological syndromes (PNS) are uncommon and imperfectly understood and, therefore, are frequently underdiagnosed...
  17. ncbi Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies
    H Kawano
    Department of Anesthesiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Zentsuji, Japan
    Anaesthesia 66:515-8. 2011
    Paraneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor and exhibits various manifestations including ..
  18. ncbi Human limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission
    Tatjana Lalic
    MRC Anatomical Neuropharmacology Unit, Oxford, UK
    Epilepsia 52:121-31. 2011
    b>Limbic encephalitis (LE) is a central nervous system (CNS) disease characterized by subacute onset of memory loss and epileptic seizures...
  19. ncbi Clinical analysis of anti-Ma2-associated encephalitis
    Josep Dalmau
    Department of Neurology, 3 W Gates, Division of Neuro Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain 127:1831-44. 2004
    ..Only 26% had classical limbic encephalitis. Excessive daytime sleepiness affected 32% of the patients, sometimes with narcolepsy-cataplexy and low CSF ..
  20. pmc Antibodies to CRMP3-4 associated with limbic encephalitis and thymoma
    A Knudsen
    Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Clin Exp Immunol 149:16-22. 2007
    We present a case with subacute limbic encephalitis (LE) and thymoma...
  21. ncbi Limbic encephalitis: a cause of temporal lobe epilepsy with onset in adult life
    Christian G Bien
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Behav 10:529-38. 2007
    b>Limbic encephalitis (LE) was described in the 1960s as a clinical-pathological syndrome in adults. Initially, the paraneoplastic form was the center of interest...
  22. ncbi The diagnosis and treatment of limbic encephalitis
    F Asztely
    Section of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Acta Neurol Scand 126:365-75. 2012
    The term limbic encephalitis (LE) was first introduced in 1968...
  23. ncbi Anti-N-methyl-D-aspartate receptor antibody limbic encephalitis
    G M Khadem
    Department of Medicine and Psychiatry, Taranaki Base Hospital, New Plymouth, New Zealand
    Intern Med J 39:54-6. 2009
    ..Most patients improve with immunosuppressive treatment. Raising awareness of this rare but increasingly reported condition is important, as it is responsive to treatment and potentially reversible...
  24. ncbi Temporal lobectomy for refractory status epilepticus in a case of limbic encephalitis
    Tracy Weimer
    Department of Neurology, West Virginia University Hospital, Morgantown, West Virginia 26506 9180, USA
    J Neurosurg 109:742-5. 2008
    The authors report a case of status epilepticus secondary to limbic encephalitis that was successfully treated with temporal lobectomy...
  25. ncbi An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis
    S H Wong
    Department of Neurology, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    J Neurol Neurosurg Psychiatry 81:1167-9. 2010
    Voltage-gated potassium channel antibody-positive limbic encephalitis (VGKC+LE) frequently improves with immunotherapy, although the optimum regimen is unknown...
  26. ncbi Paraneoplastic limbic encephalitis
    J M S Pearce
    Emeritus Consultant Neurologist, Department of Neurology, Hull Royal Infirmary, Hull, UK
    Eur Neurol 53:106-8. 2005
  27. ncbi Limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies mimicking Creutzfeldt-Jakob disease
    Ji Yeoun Yoo
    Yale Comprehensive Epilepsy Center, New Haven, Connecticut2Department of Neurology, Mount Sinai Hospital, New York, New York
    JAMA Neurol 71:79-82. 2014
    b>Limbic encephalitis that is associated with anti-voltage-gated potassium channel complex (VGKCC) antibodies (VGKCC syndrome) is an autoimmune, usually nonparaneoplastic form of encephalitis that is responsive to immunotherapy...
  28. ncbi Disgust and fear recognition in paraneoplastic limbic encephalitis
    Reiner Sprengelmeyer
    School of Psychology, University of St Andrews, Scotland, UK
    Cortex 46:650-7. 2010
    Paraneoplastic limbic encephalitis (PNLE) affects limbic portions of the brain associated with recognition of social signals of emotions. Yet it is not known whether this perceptual ability is impaired in individuals with PNLE...
  29. pmc Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody
    Ramon F Barajas
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, California 94143 1207, USA
    Epilepsia 51:473-7. 2010
    ..Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay...
  30. ncbi FDG-PET and MRI in potassium channel antibody-associated non-paraneoplastic limbic encephalitis: correlation with clinical course and neuropsychology
    S Fauser
    Epilepsy Center, University of Freiburg, Freiburg, Germany
    Acta Neurol Scand 111:338-43. 2005
    We report a patient with potassium channel antibody-associated non-paraneoplastic limbic encephalitis (NPLE) in whom repeated fluorodeoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) are correlated ..
  31. ncbi Anti-Ri antibodies and limbic encephalitis in a patient with carcinoid tumour of the lung
    Andreas Harloff
    J Neurol 252:1404-5. 2005
  32. ncbi Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapy
    Heidemarie Gast
    Department of Neurology, Inselspital, Bern University Hospital, University Bern, Switzerland
    Epilepsy Behav 17:555-7. 2010
    We describe a 61-year-old patient with clinical evidence of limbic encephalitis who improved with anticonvulsant treatment only, that is, without the use of immunosuppressive agents...
  33. doi Limbic encephalitis: an expanding concept
    Francesc Graus
    Neurology 70:500-1. 2008
  34. pmc Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors
    Toshika Ohkawa
    Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences NIPS, Okazaki 444 8787, Japan Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki 444 8787, Japan Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890 8544, Japan and Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Chiyoda ku, Tokyo 102 0075, Japan
    J Neurosci 33:18161-74. 2013
    ..Here, we focused on a mode of action of LGI1 autoantibodies associated with limbic encephalitis (LE), which is one of acquired epileptic disorders characterized by subacute onset of amnesia and seizures...
  35. ncbi A case of smoldering anti-leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis with faciobrachial dystonic seizure
    Yuriko Nakaoku
    Department of Neurology, Kyoto University Graduate School of Medicine
    Rinsho Shinkeigaku 53:706-11. 2013
    ..59-year-old right-handed woman with smoldering leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis (LE) following faciobrachial dystonic seizures...
  36. ncbi Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody types
    Annette Baumgartner
    Department of Neurology, Albert Ludwigs University Freiburg, Breisacher Str 64, 79106, Freiburg, Germany
    J Neurol 260:2744-53. 2013
    In parallel to the detection of new neuronal autoantibodies, the diagnosis of non-infectious limbic encephalitis has risen...
  37. ncbi Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy
    C G Bien
    Departments of Epileptology, University of Bonn, Germany
    Neurology 55:1823-8. 2000
    To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm.
  38. ncbi Neuropsychological course of voltage-gated potassium channel and glutamic acid decarboxylase antibody related limbic encephalitis
    C Frisch
    Department of Epileptology, University of Bonn Medical Center, Bonn, Germany
    Eur J Neurol 20:1297-304. 2013
    Autoantibodies (abs) to glutamic acid decarboxylase (GAD) and to voltage-gated potassium channels (VGKC) induce distinct courses of limbic encephalitis, related to MRI findings, seizure outcome and cognition.
  39. ncbi 18F-FDG PET/CT findings in voltage-gated potassium channel limbic encephalitis
    Koramadai Karuppuswamy Kamaleshwaran
    Kovai Medical Centre and Hospital, Coimbatore, India
    Clin Nucl Med 38:392-4. 2013
    b>Limbic encephalitis (LE) can be associated with cancer, viral infection, or be idiopathic. One such rare but treatable form is associated with voltage-gated potassium channel (VGKC) antibodies...
  40. ncbi What should you know about limbic encephalitis?
    Sara Machado
    Neurology Department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal
    Arq Neuropsiquiatr 70:817-22. 2012
    ..Hence, early recognition and prompt initiation of immunotherapies are of great importance...
  41. ncbi Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Neurology 69:1236-44. 2007
    ..There have been few studies of adult-onset disease. We recognized that some adult individuals have evidence of limbic encephalitis (LE), an autoimmune condition of adult life, which we proposed might lead directly to this syndrome.
  42. ncbi Autoimmune-mediated encephalitis
    Philippe Demaerel
    Department of Radiology, University Hospitals K U Leuven, Herestraat 49, 3000 Leuven, Belgium
    Neuroradiology 53:837-51. 2011
    ..This report is based on a review of the literature (except the literature in Japanese) and own findings in patients with autoimmune-mediated encephalitis...
  43. ncbi Acute nonparaneoplastic limbic encephalitis in childhood: a case series in Japan
    Hiroshi Sakuma
    Department of Child Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Pediatr Neurol 43:167-72. 2010
    b>Limbic encephalitis not associated with malignancy was investigated in Japanese children, with particular focus on clinical features distinct from adult cases...
  44. ncbi [Antibodies to glutamate receptor in limbic encephalitis]
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi ku, Shizuoka, Japan
    Brain Nerve 62:827-37. 2010
    ..In non-paraneoplastic, non-herpetic acute limbic encephalitis (NHALE), serum antibodies to GluRepsilon2 (NR2B) were detected in approximately 60% of the patients from ..
  45. ncbi Limbic encephalitis presenting with seizures, anterograde amnesia, and psychosis in a patient seven weeks status post immature ovarian teratoma removal
    Brian Kleyensteuber
    Department of Mental Health, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA
    Mil Med 175:616-8. 2010
    ..Based on the clinical picture, the working diagnosis was changed to delirium due to paraneoplastic limbic encephalitis. A course of intravenous immunoglobins (IVIg), and high dose steroids was administered...
  46. ncbi A case of voltage-gated potassium channel antibody-related limbic encephalitis
    Tim Harrower
    Addenbrooke s Hospital, Cambridge, UK
    Nat Clin Pract Neurol 2:339-43; quiz following 343. 2006
    ..He had become apathetic and uninterested in his family. He had no relevant past medical or family history. General and physical neurological examinations were unremarkable, as was bedside cognitive testing...
  47. ncbi Non-paraneoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodies
    Sabrina Matà
    Department of Neurological and Psychiatric Sciences, University of Firenze, Italy
    J Neuroimmunol 199:155-9. 2008
    b>Limbic encephalitis (LE) is a neurological syndrome that may present in association with cancer, infection, or as an isolate clinical condition often accompanying autoimmune disorders...
  48. pmc Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptor
    L Bataller
    Service of Neurology, Hospital Universitari La Fe, Avenida de Campanar 21, 46009 Valencia, Spain
    Neurology 74:265-7. 2010
  49. ncbi Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6
    W W Seeley
    Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Neurology 69:156-65. 2007
    Acute limbic encephalitis has been reported in the setting of treatment-related immunosuppression and attributed to human herpesvirus-6 (HHV6) infection...
  50. ncbi [Non-herpetic acute limbic encephalitis-like manifestation in a case of Hashimoto's encephalopathy with positive autoantibodies against ionotropic glutamate receptor epsilon2]
    Akihiro Shindo
    Department of Neurology, Mie University Graduate School of Medicine
    Rinsho Shinkeigaku 47:629-34. 2007
    ..The tentative clinical diagnosis was non-herpetic acute limbic encephalitis (NHALE), and administration of methylprednisolone improved her conditions...
  51. ncbi Paraneoplastic limbic encephalitis attributable to thymoma
    Mohammed S Chaudhry
    Department of Oncology, Addenbrookes Hospital, Cambridge, United Kingdom
    J Thorac Oncol 2:879-80. 2007
  52. ncbi Spontaneously resolving seronegative autoimmune limbic encephalitis
    Souhel Najjar
    Departments of Neurology, Pathology Division of Neuropathology, Neurosurgery and Psychiatry, NYU Comprehensive Epilepsy Center, New York University School of Medicine, New York, NY, USA
    Cogn Behav Neurol 24:99-105. 2011
    We describe a patient with seronegative autoimmune limbic encephalitis (SNALE) masquerading as glioma. Brain magnetic resonance imaging (MRI) abnormalities, distinctive pathological findings, and spontaneous remission are highlighted.
  53. ncbi Serial MRI of limbic encephalitis
    Horst Urbach
    Department of Radiology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroradiology 48:380-6. 2006
    The aim of the study was to analyze serial magnetic resonance imaging (MRI) scans in patients with various forms of limbic encephalitis (LE) in order to evaluate whether, and at what time point, MRI findings support the diagnosis of LE.
  54. ncbi Plasma exchange for anti GAD associated non paraneoplastic limbic encephalitis
    Gustavo Mazzi
    Servizio di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliera Santa Maria degli Angeli Via Montereale 24, 33170 Pordenone, Italy
    Transfus Apher Sci 39:229-33. 2008
    b>Limbic encephalitis (LE) is a neurological syndrome usually presenting in a paraneoplastic form...
  55. ncbi Limbic encephalitis associated with anti-GAD antibody and common variable immune deficiency
    Cigdem I Akman
    Comprehensive Epilepsy Center, Department of Neurology, Division of Pediatric Neurology and Epilepsy, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Dev Med Child Neurol 51:563-7. 2009
    A variety of autoantibodies have been identified with complex neurological disorders including limbic encephalitis. The underlying trigger for the immune-mediated process and the role of autoantibodies in the pathogenesis of limbic ..
  56. ncbi Paraneoplastic limbic encephalitis: case report
    S Cakirer
    Department of Radiology, Neuroradiology Section, Istanbul Sisli Etfal Hospital, 80220 Istanbul, Turkey
    Comput Med Imaging Graph 26:55-8. 2002
    Paraneoplastic limbic encephalitis, which is also known as the remote neurological effect of cancer, is a rare neurological paraneoplastic disorder that usually presents with changes in mental status and behavioral abnormalities...
  57. ncbi Successful treatment of acute autoimmune limbic encephalitis with negative VGKC and NMDAR antibodies
    Anna Modoni
    Department of Neuroscience, Catholic University of Sacred Heart, Rome, Italy
    Cogn Behav Neurol 22:63-6. 2009
    To describe a case of acute nonherpetic limbic encephalitis (LE) with negative testing for antibodies directed against onconeuronal and cell membrane antigens, including voltage-gated potassium channels and N-methyl-D-aspartate receptor, ..
  58. ncbi Nonparaneoplastic limbic encephalitis with relapsing polychondritis
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Neurol Sci 220:85-8. 2004
    ..This is thought to be the first case of RP presenting amnesic syndrome and mental disorder associated with nonparaneoplastic limbic encephalitis involving bilateral hippocampi and amygdaloidal bodies detected by MRI.
  59. ncbi Focal paraneoplastic limbic encephalitis presenting as orgasmic epilepsy
    C E Fadul
    Department of Medicine Sections of Hematology Oncology and Neurology, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    J Neurooncol 72:195-8. 2005
    To report orgasmic epilepsy as a manifestation of paraneoplastic limbic encephalitis in a patient with small cell lung cancer.
  60. ncbi Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review
    J M Reid
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Scott Med J 54:27-31. 2009
    The syndrome of limbic encephalitis (LE) associated with antibodies against voltage-gated potassium channels (VGKC-LE) has recently been described. The number of published cases is however small...
  61. ncbi Unusual amnesia in a patient with VGKC-Ab limbic encephalitis: a case study
    Luke D Kartsounis
    Essex Neurosciences Centre, Queen s Hospital, Romford, Essex, UK
    Cortex 47:451-9. 2011
    ..We argue that the reported case broadens the phenomenology of VGKC-Ab limbic encephalitis and raises important theoretical questions about the aetiology of this patient's most unusual memory ..
  62. ncbi Navigation around London by a taxi driver with bilateral hippocampal lesions
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology University College London, London, UK
    Brain 129:2894-907. 2006
    ....
  63. ncbi Limbic encephalitis and variants: classification, diagnosis and treatment
    Erdem Tuzun
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurologist 13:261-71. 2007
    Recent studies suggest that a substantial number of patients with autoimmune limbic encephalitis may improve if properly diagnosed and treated...
  64. ncbi Hypothermia in VGKC antibody-associated limbic encephalitis
    S Jacob
    Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Neurol Neurosurg Psychiatry 79:202-4. 2008
    Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders...
  65. ncbi Asymmetric cerebellar ataxia and limbic encephalitis as a presenting feature of primary Sjögren's syndrome
    Kiren Collison
    J Neurol 254:1609-11. 2007
  66. pmc Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampus
    H Shimazaki
    J Neurol Neurosurg Psychiatry 78:324-5. 2007
  67. pmc Autoimmune limbic encephalitis in 39 patients: immunophenotypes and outcomes
    L Bataller
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 78:381-5. 2007
    About 40% of patients with limbic encephalitis do not have detectable CNS antibodies. Some of these patients have immune-mediated limbic encephalitis, but their frequency is unknown.
  68. pmc Paraneoplastic limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumour
    Luigi Zuliani
    J Neurol Neurosurg Psychiatry 78:204-5. 2007
  69. ncbi Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis
    Andrew Lee
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA
    J ECT 22:267-70. 2006
    Paraneoplastic limbic encephalitis is a rare disorder that can cause memory loss, confusion, personality change, cognitive dysfunction, and psychosis...
  70. pmc Course and outcome of acute limbic encephalitis with negative voltage-gated potassium channel antibodies
    S R Samarasekera
    Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 78:391-4. 2007
    b>Limbic encephalitis is a potentially treatable immunological condition...
  71. ncbi Non-herpetic acute limbic encephalitis: cerebrospinal fluid cytokines and magnetic resonance imaging findings
    Kyoko Asaoka
    First Department of Internal Medicine, Kurume University School of Medicine, Kurume
    Intern Med 43:42-8. 2004
    Non-herpetic acute limbic encephalitis (non-herpetic ALE) is regarded as a new subgroup of limbic encephalitis...
  72. ncbi Voltage-gated potassium channel antibodies in limbic encephalitis
    Patricia Pozo-Rosich
    Neurosciences Group, Weatherall Insitute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Neurol 54:530-3. 2003
    We found voltage-gated potassium channel (VGKC) antibodies in 4 of 15 patients with limbic encephalitis (LE)...
  73. ncbi EBV limbic encephalitis after allogenic hematopoietic stem cell transplantation
    Stephane Kremer
    UMR 7191 LINC, Service de Radiologie 2, Hopital Hautepierre, Universite de Strasbourg, CHU de Strasbourg, Strasbourg, France
    J Neuroradiol 37:189-91. 2010
    ..We report here a case of post-transplant acute limbic encephalitis (PALE) syndrome that was possibly related to EBV infection...
  74. ncbi Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis
    Alex Iranzo
    Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, C Villaroel 170, 08036 Barcelona, Spain
    Ann Neurol 59:178-81. 2006
    Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage-gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage-..
  75. ncbi Autoantibodies to neuronal surface antigens in thyroid antibody-positive and -negative limbic encephalitis
    Erdem Tuzun
    Department of Neurology, Istanbul University, Istanbul Faculty of Medicine, Turkey, Turkey
    Neurol India 59:47-50. 2011
    ..However, the presence of Thy-Abs in a cohort of limbic encephalitis (LE) patients and their association with anti-neuronal autoimmunity has not been explored.
  76. ncbi CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis
    S E Monstad
    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway
    J Neurol Neurosurg Psychiatry 80:241-2. 2009
    ..antibodies are often associated with thymoma or small cell lung cancer and paraneoplastic syndromes such as limbic encephalitis (LE)...
  77. ncbi Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations
    Kleopas A Kleopa
    Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, PA, USA
    Brain 129:1570-84. 2006
    ..is called Morvan's syndrome (MoS); and CNS manifestations without peripheral involvement is called limbic encephalitis (LE)...
  78. ncbi CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis
    S Jarius
    Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom
    J Neurol Sci 268:74-7. 2008
    Recently, a new subtype of limbic encephalitis (LE) has been described, serologically characterized by the presence of antibodies against voltage gated potassium channels (VGKC, to be called VGKC-LE)...
  79. ncbi [A child with non-herpetic acute limbic encephalitis]
    H Yoshikawa
    No To Hattatsu 35:429-31. 2003
  80. ncbi Acute limbic encephalitis: a new entity?
    Yoko Mochizuki
    Department of Pathology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
    Neurosci Lett 394:5-8. 2006
    ..Recently, these cases have been named "non-herpetic acute limbic encephalitis"...
  81. doi Treatment-responsive subacute limbic encephalitis and NMDA receptor antibodies in a man
    Maria Elena Novillo-López
    Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain
    Neurology 70:728-9. 2008
  82. ncbi Pitfalls in diagnosing limbic encephalitis - a case report
    F Kerling
    Epilepsy Center ZEE, Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Acta Neurol Scand 118:339-42. 2008
    The syndrome of limbic encephalitis (LE) is characterized by subacute onset of temporal lobe epilepsy, loss of short-term memory, cognitive confusion and psychiatric symptoms.
  83. ncbi Long-term cognitive and MRI findings in a patient with paraneoplastic limbic encephalitis
    T Benke
    Clinic of Neurology, University of Innsbruck, Austria
    J Neurooncol 66:217-24. 2004
    ..This case of paraneoplastic encephalitis suggests that the related atrophy may present as a chronic, progressive, multifocal encephalopathy and that the associated cognitive impairments may include several cognitive domains...
  84. ncbi MRI and diffusion MRI in nonparaneoplastic limbic encephalitis
    R N Sener
    Department of Radiology, Ege University Hospital, 35100 Bornova, Izmir, Turkey
    Comput Med Imaging Graph 26:339-42. 2002
    This paper reports an 65-year-old woman with nonparaneoplastic limbic encephalitis. On MRI and diffusion MRI, diffuse and symmetrical, bilateral high-signal lesions were evident in the medial temporal lobes...
  85. pmc Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitis
    Erdem Tuzun
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neuroimmunol 186:177-80. 2007
    We report two men with limbic encephalitis (LE) refractory to corticosteroids, IVIg and plasma exchange. Both patients had serum/CSF antibodies that reacted with the cytoplasm of neurons...
  86. ncbi Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girl
    A C W Lee
    Departments of Paediatrics, Tuen Mun Hospital, New Territories, Hong Kong, China
    Acta Paediatr 92:506-9. 2003
    ..To describe an unusual but treatable cause of behavioural disturbance in adolescence...
  87. ncbi Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody
    M J Thieben
    Department of Neurology, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 62:1177-82. 2004
    ....
  88. ncbi [Limbic encephalitis: a probably under-recognized syndrome]
    F Graus
    Servicio de Neurologia, Hospital Clinic, Barcelona
    Neurologia 20:24-30. 2005
    b>Limbic encephalitis was identified as a clinicopathological entity in 1968. Up to a few years ago, 200 cases were described, most associated with lung cancer and more infrequently with other tumors...
  89. pmc Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations
    F Graus
    Servei de Neurologia, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Neurology 71:930-6. 2008
    To report the frequency and type of antibodies against neuronal surface antigens (NSA-ab) in limbic encephalitis (LE).
  90. doi Case records of the Massachusetts General Hospital. Case 26-2008. A 26-year-old woman with headache and behavioral changes
    Thomas D Sabin
    Department of Neurology, Tufts Medical Center, Boston, USA
    N Engl J Med 359:842-53. 2008
  91. ncbi [Paraneoplastic limbic encephalitis and epidermoid carcinoma of the pyriform]
    M A Sobas
    Servicios de Medicina Interna, Hospital de Conxo, Complejo Hospitalario Universitario, Santiago de Compostela CHUS
    An Med Interna 23:331-4. 2006
    Paraneoplastic limbic encephalitis is a syndrome characterised by behaviour changes, short-term memory loss and seizures...
  92. ncbi [Limbic encephalitis--a diagnostic challenge]
    Anette Storstein
    Nevrologisk avdeling, Haukeland Universitetssjukehus, 5021 Bergen
    Tidsskr Nor Laegeforen 127:3077-80. 2007
    The etiology of limbic encephalitis (LE) is often autoimmune. Autoimmune LE is often paraneoplastic and should be suspected in patients with subacute confusional states...
  93. ncbi Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses
    R Scheid
    J Neurol 252:1129-32. 2005
  94. ncbi Potassium channel antibodies in two patients with reversible limbic encephalitis
    C Buckley
    Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Ann Neurol 50:73-8. 2001
    b>Limbic encephalitis (LE) is often associated with lung, thymic, or testicular tumours and antibodies to Hu, CV2, or Ma2 (Ta) antigens. In these cases, it generally has a poor prognosis...
  95. ncbi Paraneoplastic limbic encephalitis in a teenage girl with an immature ovarian teratoma
    Rebecca Stein-Wexler
    Department of Radiology, University of California, Davis Medical Center and U C Davis Children s Hospital, Sacramento, CA 95817, USA
    Pediatr Radiol 35:694-7. 2005
    Paraneoplastic limbic encephalitis (PLE) is an unusual disorder that is characterized by the association of clinical limbic system abnormalities with neoplasia, usually malignancy...
  96. ncbi Human herpesvirus 6 limbic encephalitis after stem cell transplantation
    M S Wainwright
    Division of Pediatric Neurology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, IL, USA
    Ann Neurol 50:612-9. 2001
    ..Because of its subtle clinical presentation, this syndrome may be underrecognized, but can be diagnosed with appropriate magnetic resonance imaging techniques, EEG monitoring, and cerebrospinal fluid viral studies...
  97. pmc A new anti-neuronal antibody in a case of paraneoplastic limbic encephalitis associated with breast cancer
    R Scheid
    Day Clinic of Cognitive Neurology, University of Leipzig, and Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    J Neurol Neurosurg Psychiatry 75:338-40. 2004
    Paraneoplastic neurological syndromes are rare remote effects of different types of cancer. Paraneoplastic limbic encephalitis is a specific syndrome, most often associated with small cell lung carcinoma...
  98. ncbi Paraneoplastic limbic encephalitis--case report and review of literature
    Sunil K Munshi
    Department of Cerebrovascular Medicine and Medicine for the Elderly, Leicester General Hospital, University Hospital of Leicester, Gwendolen Road, Leicester LE5 4PW, UK
    Age Ageing 34:190-3. 2005
    ..for his illness could be detected in his lifetime, but at post mortem he was found to have paraneoplastic limbic encephalitis and a bronchogenic tumour...
  99. pmc Memory lost, memory regained: neuropsychological findings and neuroimaging in two cases of paraneoplastic limbic encephalitis with radically different outcomes
    T H Bak
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    J Neurol Neurosurg Psychiatry 71:40-7. 2001
    OBJECTIVE: To report two cases of paraneoplastic limbic encephalitis (PNLE) with similar clinical presentation, but dramatically different outcome and to highlight the role of neuropsychological and radiological evaluation in PNLE...
  100. ncbi [Recent topics on paraneoplastic neurological syndromes: anti-glycolipid antibodies]
    Tatsuro Muto
    Nihon Naika Gakkai Zasshi 97:1844-50. 2008
  101. ncbi Complicated paraneoplastic neurological syndromes: a report of two patients with small cell or non-small cell lung cancer
    Yukiko Hiasa
    First Department of Internal Medicine, University of Tokushima School of Medicine, 3 Kuramoto cho, Tokushima City, Tokushima 770 8503, Japan
    Clin Neurol Neurosurg 106:47-9. 2003
    ..Patient 1 showed paraneoplastic limbic encephalitis (PLE), paraneoplastic sensory neuropathy (PSN) and Lambert-Eaton myasthenic syndrome (LEMS) associated with ..

Research Grants5

  1. Paraneoplastic Disorders of CNS: Autoantigen Profiling
    Josep Dalmau; Fiscal Year: 2007
    ..identification of autoantigens specific for the three most common PNDs of the CNS: cortical and limbic encephalitis, cerebellar degeneration, and brainstem encephalitis...
  2. Immune evasion in a humanized mouse model of HHV-6 infection
    Amy W Hudson; Fiscal Year: 2013
    ..HHV-6 also reactivates in hematopoietic cell transplant recipients, resulting in poor neurocognitive outcome and can result in acute limbic encephalitis (3,4).
  3. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. FMRI/Pathology/Anterior Cingulate/Frontoinsular Cortex
    WILLIAM SEELEY; Fiscal Year: 2007
    ..The proposed research seeks to benefit the public health by clarifying the biological basis of dementia, ultimately promoting earlier diagnosis and better treatments for dementia patients. ..
  5. Immunity to brain Ma proteins: A remote effect of cancer
    Josep Dalmau; Fiscal Year: 2007
    ..We initially identified this disorder in men with testicular tumors and brainstem and limbic encephalitis (LE: memory deficits, seizures, sleep disorders) who developed antibodies to neuronal proteins expressed by ..