central nervous system fungal infections
Summary: MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
Publications171 found, 100 shown here
- Chronic granulomatous disease presenting with disseminated intracranial aspergillosisAbdul Alsultan
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Pediatr Blood Cancer 47:107-10. 2006..Whereas, optimal pharmacologic therapy is still unknown for CNS aspergillosis, voriconazole may have an advantage due to its ability to cross the blood brain barrier and excellent oral absorption and bioavailability...
- Imaging features of central nervous system fungal infectionsKrishan K Jain
Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
Neurol India 55:241-50. 2007..The radiographic appearance alone is often not specific, but the combination of the appropriate clinical setting along with computed tomography or magnetic resonance may help to suggest the correct diagnosis...
- Current approaches to management of cerebral fungal infection in pediatric patients with hematologic disordersTomonobu Sato
Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
J Pediatr Hematol Oncol 30:249-53. 2008..It is important to perform aggressive multimodality treatment, when indicated, including surgical intervention, even if in myelosuppression...
- Immunopathogenesis of central nervous system fungal infectionsJohn Dotis
3rd Department of Pediatrics, Aristotle University, Hippokration Hospital, GR 54642 Thessaloniki, Greece
Neurol India 55:216-20. 2007....
- Activity of posaconazole in the treatment of central nervous system fungal infectionsPunnee Pitisuttithum
Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
J Antimicrob Chemother 56:745-55. 2005..In this subanalysis, we report on those subjects in this trial who had a fungal infection that involved the CNS...
- Cerebral phaeohyphomycosis mimics high-grade astrocytomaErik F Hauck
Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8855, USA
J Clin Neurosci 15:1061-6. 2008..Early biopsy establishing the diagnosis, followed by aggressive combined surgical and medical management is necessary for a good outcome...
- Multiple brain abscesses due to Penicillium spp infectionDanilo Teixeira Noritomi
Gastroenterology Department, Hospital das Clinicas, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil
Rev Inst Med Trop Sao Paulo 47:167-70. 2005..Penicillium spp infection caused by species other than P. marneffei normally cause only superficial or allergic disease but rare cases of invasive disease do occur. We report the fourth case of Penicillium spp CNS infection...
- Management of cryptococcosis in non-HIV-related patientsZhirong Yao
Department of Dermatology Xinhua Hospital, Shanghai Second Medical University, Shanghai, China
Med Mycol 43:245-51. 2005..In group III, thirty-nine out of forty patients were cured without recurrence. These results indicate that the two-phase protocol was more desirable for the treatment of non-HIV associated cryptococcal infection of CNS...
- Improved outcome in central nervous system aspergillosis, using voriconazole treatmentStefan Schwartz
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Blood 106:2641-5. 2005..We conclude from this large cohort of patients that voriconazole treatment together with neurosurgical management, whenever feasible, is currently the best approach to treat patients with CNS aspergillosis...
- [Central nervous system paracoccidioidomycosis: analysis of 13 cases]Walter J Fagundes-Pereyra
Clínica Neurológica e Neurocirúrgica da Santa Casa de Belo Horizonte, MG, and Centro Universitário de Vila Velha, Brazil
Arq Neuropsiquiatr 64:269-76. 2006..9) months. In conclusion, the CNS involvement in paracoccidioidomycosis is more frequent and more serious than thought before. The clinical manifestations, CT scans and MRI findings are not specific of paracoccidioidomycosis...
- Intracranial fungal granuloma: analysis of 40 patients and review of the literatureArvind Dubey
Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130 3932, USA
Surg Neurol 63:254-60; discussion 260. 2005..To describe the characteristics of patients diagnosed with intracranial fungal granuloma (IFG) in the largest reported series to date (to our knowledge)...
- Isolated primary intracerebral mycetoma: presenting as a mass lesion in a patient with prostate cancer and multiple myelomaShyam Prabhakaran
Department of Neurology and Neuroscience, New York Presbyterian Hospital Weill Medical Center of Cornell University, USA
J Neurooncol 71:49-52. 2005..A brief review of the literature discusses the rarity, presentation, diagnosis, and management of primary intracerebral mycetomas...
- Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathyPeterus Thajeb
Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan, ROC
Scand J Infect Dis 36:643-8. 2004..To improve outcome, a combination of early radical debridement, ocular exenteration, parenteral and local administration of amphotericin B, and decompression craniotomy should be considered...
- Unsuccessful treatment with voriconazole of a brain abscess due to Cladophialophora bantianaAlberto Fica
Sección Infectología, Hospital Clinico U de Chile, Santiago, Chile
Scand J Infect Dis 35:892-3. 2003..We report a case of CNS infection in this agent unsuccessfully treated by surgery and various antifungal compounds including high doses of voriconazole (6 mg/kg bid). No adverse effects related to this compound were observed...
- [Histoplasmoma as isolated central nervous system lesion in an immunocompetent patient]Emerson L Gasparetto
Serviço de Radiologia Médica e Diagnóstico por Imagem, Hospital de Clinicas, Universidade Federal do Parana, Curitiba, PR, Brazil
Arq Neuropsiquiatr 63:689-92. 2005..The stereotactic biopsy was performed and the histological diagnosis of histoplasmosis was defined. The treatment was initiated with fluconazole. The patient showed important clinical improvement after 6 months...
- Successful treatment with voriconazole of fungal cerebral abscess due to Cladophialophora bantianaMark K Lyons
Department of Neurological Surgery, Mayo Clinic Scottsdale, Mayo Clinic College of Medicine, 13600 East Shea Boulevard, Scottsdale, AZ 85259, USA
Clin Neurol Neurosurg 107:532-4. 2005..bantiana fungal infections have become more common in recent years. Aggressive and continuous treatment with voriconazole may offer an improved chance of survival in these patients...
- Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosisKarl V Clemons
California Institute for Medical Research, Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
Antimicrob Agents Chemother 49:4867-75. 2005..These results indicate that AmBi in combination with VCZ may be superior for treatment of CNS aspergillosis; combinations of AmBi and MICA or CAS were not antagonistic and may have a slight benefit...
- Fungal brain infectionsEileen P Scully
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Neurol 21:347-52. 2008....
- Cerebral blastomycosis: a case reportBal Chander
Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi
Indian J Pathol Microbiol 50:821-4. 2007..Only two cases of intracranial extra-axial blastomycosis have been reported from India, and we report the third case, which presented as meningioma in a 23-year old female...
- Efficacy of voriconazole in a murine model of cryptococcal central nervous system infectionCarolina Serena
Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain
J Antimicrob Chemother 60:162-5. 2007..We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally...
- Fungal infections of the CNS: treatment strategies for the immunocompromised patientKatharine E Black
Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA
CNS Drugs 21:293-318. 2007..Effective treatment requires a definitive diagnosis, which is often challenging in the population at risk of CNS fungal infections...
- Cerebral blastomycosis: a case series incorporating voriconazole in the treatment regimenSergio M Borgia
William Osler Health Centre, Ontario, Canada
Med Mycol 44:659-64. 2006....
- Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosisCaitlin Reed
Antimicrob Agents Chemother 50:3968-9. 2006
- Aspergillus brain abscess in a patient with acute myeloid leukaemia successfully treated with voriconazoleF Wandroo
Department of Haematology, Sandwell and West Birmingham Hospital, Lyndon Road, West Bromwich, West Midlands B714HJ, UK
Clin Lab Haematol 28:130-3. 2006..These newer azoles may change the outlook of this fatal condition. We report here a patient with cerebral aspergillosis who was successfully treated with voriconazole...
- Mucormycosis presenting with painful ophthalmoplegiaB Karakurum
Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Department of Neurology, Adana, Turkey
Acta Neurol Belg 105:201-5. 2005..The possibility of mucormycosis should be investigated in any patient with painful ophthalmoplegia, and prompt otorhinolaryngologic examination is recommended to ensure rapid diagnosis and treatment...
- Primary central nervous system phaeohyphomycosis: a review of 101 casesSanjay G Revankar
Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
Clin Infect Dis 38:206-16. 2004..Complete excision of brain lesions may provide better results than simple aspiration. An aggressive medical and surgical approach is warranted in treating these infections to optimize outcomes...
- Antifungal therapy for central nervous system histoplasmosis, using a newly developed intracranial model of infectionRoss R Haynes
Histoplasmosis Reference Laboratory, Department of Medicine, Indiana University School of Medicine, 1001 W 10th Street, OPW 430, Indianapolis, IN 46202 2879, USA
J Infect Dis 185:1830-2. 2002..The hypothesis that amphotericin B-fluconazole combination therapy would be superior to amphotericin B monotherapy for treatment of CNS histoplasmosis was not supported by this study...
- CNS-aspergillosis: are there new treatment options?S Schwartz
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Freie Universitat, Hindenburgdamm 30, D 12200 Berlin, Germany
Mycoses 46:8-14. 2003..However, additional clinical data are needed to determine more precisely the role of voriconazole in CNS aspergillosis. In this review, we have compiled the available pharmacological and clinical data on CNS aspergillosis...
- Cryptococcosis of the central nervous system in a dogTherese E O'Toole
Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
J Am Vet Med Assoc 222:1722-5, 1706. 2003..Monitoring serum latex agglutination test results may provide a safe, less invasive means of monitoring response to treatment...
- [Invasive rhinocerebral aspergillosis occurred during myelosuppressive phase after chemotherapy: a case report and literature review]Z Yu
HSCT Center, Affiliated Hospital of Academy of Military Medical Science, Beijing 100039, China
Zhonghua Xue Ye Xue Za Zhi 22:366-9. 2001..CONCLUSION: For most of the IRA, there remains no effective treatment. The best treatment is AmB in combination with surgical excision...
- Cerebral phaeohyphomycosis masquerading as a parafalcian mass: case reportHooshang Saberi
Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Surg Neurol 60:354-9; discussion 359. 2003..Cerebral phaeohyphomycosis caused by Fonsecaea pedrosoi is a rarity. However, about four cases have been reported in the literature. The disease remains mostly fatal despite employment of new treatment modalities...
- [Central nervous system involvement by histoplasmosis as the unique manifestation of this disease in immunocompetent patients: presentation of two cases]Guido C Levi
Serviço de Moléstias Infecciosas, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, Sao Paulo, SP, Brasil
Arq Neuropsiquiatr 61:859-63. 2003..Comments about the diversity of clinical presentation and main differential diagnosis are presented. We analyze the serologic and cerebrospinal fluid results and, finally, discuss the drugs and duration of treatment...
- Cerebellar aspergillosis in an infant: case reportSandeep Mohindra
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Neurosurgery 58:E587; discussion E587. 2006..Immunocompetent patients harboring invasive intracranial fungal infections still remain an elusive diagnosis...
- Bacterial meningitis and other nonviral infections of the nervous systemThomas P Bleck
Rush Medical College, Rush University Medical Center, 600 South Paulina Street, 544 AF, Chicago, IL 60612, USA Electronic address
Crit Care Clin 29:975-87. 2013....
- Central nervous system fungal infections in tropicsN Khandelwal
Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Neuroimaging Clin N Am 21:859-66, viii. 2011..must have high degree of suspicion in immunocompromised patients regarding the possibility of central nervous system fungal infections and keep in mind the appearances of various fungi even when immune response is intact...
- Intraventricular cryptococcal cysts masquerading as racemose neurocysticercosisMarlon Mathews
Department of Neurosurgery, University of California, Irvine, Orange, CA 92868
Surg Neurol 67:647-9. 2007..We report a case in which intraventricular cryptococcal cysts clinically and radiologically simulated the racemose form of neurocysticercosis...
- Unusual complications and presentations of intracranial abscess: experience of a single institutionHasan Kocaeli
Department of Neurosurgery, Uludag University School of Medicine, Gorukle Campus, Bursa 16059, Turkey
Surg Neurol 69:383-91; discussion 391. 2008..This study was undertaken to shed light on the unusual complications and presentations of intracranial abscess treated at a single institution...
- Neuroimaging of infectionsOliver Kastrup
Department of Neurology, University Duisburg Essen, 45122 Essen, Germany
NeuroRx 2:324-32. 2005..In patients with herpes simplex and more exotic viruses like West Nile and Murray Valley virus DWI allows earlier lesion detection and therapeutic intervention with virustatic drugs...
- Successful treatment of a giant isolated cerebral mucormycotic (zygomycotic) abscess using endoscopic debridement: case report and therapeutic considerationsPhilippe Metellus
Départamentes de Neurochirurgie, Hopital Timone, Marseille, France
Surg Neurol 69:510-5; discussion 515. 2008..Cerebral mucormycosis without rhino-orbital or systemic involvement is an extremely rare condition mostly associated with parenteral drug abuse...
- MRI with Magnetic Resonance Spectroscopy of multiple brain abscesses secondary to Scedosporium apiospermum in two immunocompromised patientsH Wayne Slone
The Ohio State University, Department of Radiology, Columbus, OH 43210, USA
Clin Imaging 37:361-6. 2013..In the appropriate clinical setting, conventional MR imaging and MR spectroscopy may facilitate diagnosis, earlier initiation of antifungal pharmacotherapy and surgical intervention in this frequently fatal infection...
- Iatrogenic fungal infections of central nervous systemSourabh Lahoti
Department of Neurology, University of Kentucky College of Medicine, Room L 445, Kentucky Clinic, Lexington, KY, 40515, USA
Curr Neurol Neurosci Rep 13:399. 2013..rostratum infection. The current therapeutic recommendation is a 6 mg/kg dose of voriconazole every 12 h followed by liposomal amphotericin B. In some instances, surgical debridement and drainage may be necessary...
- Fungal infections of the nervous system: current perspective and controversies in managementRewati Raman Sharma
National Neurosurgical Centre, Khoula Hospital, PO Box 90, Postal Code 116, Muscat, Oman
Int J Surg 8:591-601. 2010..Now evidence based data are gathering together in favor of their usefulness in the management of invasive fungal infections. But still, many questions are unanswered and controversies persist relating to their selection and use...
- Cerebral phaeohyphomycosis caused by Cladosporium spp. in two domestic shorthair catsChristopher L Mariani
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Health Science Center, University of Florida, Gainesville 32610 0126, USA
J Am Anim Hosp Assoc 38:225-30. 2002..Euthanasia was performed in both cats, and postmortem diagnoses of phaeohyphomycosis secondary to Cladosporium spp. were made based on histopathology and fungal culture in both cats...
- Cure of ventriculitis and central nervous system shunt infection by Staphylococcus epidermidis with vancomycin by intraventricular injection in a liver transplant recipientM Schwabe
Department of Hematology and Oncology, Univerity of Freiburg Medical Center, Freiburg, Germany
Transpl Infect Dis 9:46-50. 2007..Intraventricular injection of vancomycin is an effective and safe procedure to eradicate S. epidermidis from the central nervous system when i.v. vancomycin treatment fails...
- Cure of disseminated zygomycosis with cerebral involvement using high dose liposomal amphotericin B and surgerySanjay G Revankar
Wayne State University, Harper University Hospital, Detroit, Michigan 48201, USA
Med Mycol 45:183-5. 2007..Since penetration of the central nervous system by amphotericin B is poor the application of high dose therapy may be useful in cases of cerebral zygomycosis...
- Co-infection of HIV and tropical infectious agents that affect the nervous systemL Chimelli
Division of Pathology, National Institute of Cancer, Rua Cordeiro da Graça 156, Santo Cristo, Rio de Janeiro, RJ, CEP 20220 400, Brazil
Rev Neurol (Paris) 168:270-82. 2012..This article reviews some of the key diagnostic aspects of tropical infections associated with HIV infection...
- Disseminated Cladophialophora bantiana infection in a heart transplant recipientAndreas Keyser
Department of Cardiothoracic Surgery, University Hospital of Regensburg, Regensburg, Germany
J Heart Lung Transplant 21:503-5. 2002..We report the case of a heart transplant recipient with cutaneous, cerebral, and lung manifestation of Cladophialophora bantiana who died despite surgical and systemic, high-dosage itraconazole treatment...
- Immunotherapy for fungal infections with special emphasis on central nervous system infectionsIyer G Parameswaran
Division of Infectious Diseases, University at Buffalo School of Medicine, Buffalo, NY, USA
Neurol India 55:260-6. 2007..This notion is only partially accurate. Immune-based therapies for fungal CNS disease are at an exploratory level and merit further evaluation in clinical trials...
- Mortality risk factors in patients with zygomycosis: a retrospective and multicentre study of 25 casesAndreu Llorente
Servicio de Hematologia, Hospital Joan XXIII, IISPV, Tarragona, Spain
Enferm Infecc Microbiol Clin 29:263-8. 2011..To investigate mortality risk factors in patients with zygomycosis...
- Long-term outcome of neuroparacoccidioidomycosis treatmentFabio Francesconi
Dermatology Department, Manaus Oncology Control Foundation Center, Manaus, AM, Brazil
Rev Soc Bras Med Trop 44:22-5. 2011..NPCM has been described sporadically in some case reports and small case series, with little or no focus on treatment outcome and long-term follow-up...
- Long-term risk of atypical fungal infection after near-drowning episodesChristian Garzoni
Pediatrics 119:417; author reply 417-8. 2007
- [Cerebral candidiasis in a neonate]M Mata Jorge
An Pediatr (Barc) 58:194-5. 2003
- Disseminated zygomycosis due to Mycocladus corymbifera with cutaneous and cerebral involvementClare Schofield
Departments of Dermatology Neurosurgery, Royal Hobart Hospital, Hobart, Tasmania, Australia
Australas J Dermatol 54:e8-11. 2013..The skin lesions played a significant role in the diagnosis of mucormycosis. These infections have an exceedingly high mortality rate and early recognition of cutaneous lesions is essential to successful management...
- Recurrent blastomycosis of the central nervous system: case report and reviewA Chowfin
University of North Dakota School of Medicine, Fargo, ND 58122, USA
Clin Infect Dis 30:969-71. 2000..This treatment may be an alternate approach for management of similar cases...
- Brain abscess caused by Cladophialophora (Xylohypha) bantiana in a renal transplant patientE R Silveira
Department of Nephrology, Hospital Vera Cruz, Federal University of Minas Gerais, Avenida Barbacena 653, 30190 130 Belo Horizonte, Minas Gerais, Brazil
Transpl Infect Dis 5:104-7. 2003..Ten days later the patient's blood cultures became positive for Escherichia coli. After 3 days the patient died due to septic shock...
- Long term survival of patient with invasive aspergillosis involving orbit, paranasal sinus, and central nervous systemK Kusaka
Br J Ophthalmol 87:791-2. 2003
- A patient with new-onset seizure and mediastinal adenopathyMylene T Truong
Department of Diagnostic Radiology, Box 57, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Chest 126:982-5. 2004
- Aspergillosis of the central nervous system: a catastrophic opportunistic infectionPiya Pongbhaesaj
Division of Neurology, Department of Medicine, Faculty of Medicine at Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 35:119-25. 2004..It remains a catastrophic opportunistic infection in spite of the current intensive and aggressive treatment...
- Concomitant diabetic ketoacidosis and rhinocerebral mucormycosis: report of a caseBing Yin Shi
Department of Endocrinology, First Hospital of Xi an Jiaotong University, 710061, China
Chin Med J (Engl) 117:1113-5. 2004
- Brain stem candidiasis mimicking cerebellopontine angle tumorXin yu Hong
Neurosurgery Department, First Hospital of Ji Lin University, Chang Chun, China
Surg Neurol 70:87-91. 2008..Infectious process can mimic cerebral tumors. We present the first report of a fugal infection in brainstem mimicking cerebral tumors in the literature...
- Central nervous system involvement in cryptococcal infection in individuals after solid organ transplantation or with AIDSJ A Davis
Transplant Infectious Disease Program, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Transpl Infect Dis 11:432-7. 2009..Cryptococcus neoformans is an important pathogen of immunocompromised hosts. Manifestations of cryptococcal infection have not been compared between populations based on the nature of the underlying immune deficiencies...
- Aspiration cytology of brain abscess from a fatal case of cerebral phaeohyphomycosis due to Ramichloridium mackenzieiSamir S Amr
Pathology Services Division, Dhahran Health Center, Saudi Aramco Medical Services Organization, Saudi Aramco, Dhahran, Saudi Arabia
Diagn Cytopathol 35:695-9. 2007..She was on long-term corticosteroid therapy. The patient developed rapidly progressive multiple brain abscesses and died despite aspiration of the abscess and administration of intravenous amphotericin B lipid complex and voriconazole...
- Onyx embolization for the endovascular treatment of infectious and traumatic aneurysms involving the cranial and cerebral vasculatureAshutosh P Jadhav
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Neurointerv Surg 5:562-5. 2013..Onyx is a liquid non-adhesive viscous embolic agent ideal for slow targeted injections which is currently approved for the treatment of intracranial aneurysms and arteriovenous malformations...
- Cerebral cryptococcosis: atypical appearances on CTM Awasthi
Department of Radiology, King Edward VII Memorial Hospital, Acharya Donde Marg, Parel, Bombay, India
Br J Radiol 74:83-5. 2001..We report an unusual presentation of cryptococcal infection in an immunocompetent patient presenting with headache and hemiplegia. CT demonstrated a large ring-enhancing lesion in the parietal region with intralesional calcification...
- CryptococcosisJohn R Perfect
Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, PO Box 3353, Durham, NC 27710, USA
Infect Dis Clin North Am 16:837-74, v-vi. 2002..This article collates and analyzes both new and old knowledge about the pathogen to help frame the meaning of human cryptococcosis as it starts to evolve in the new millennium...
- Fungal infections of the central nervous systemJ M K Murthy
Continental Institute of Neurosciences and Rehabilitation, Continental Hospitals, IT and Financial District, Gachibowli, Hyderabad, India Electronic address
Handb Clin Neurol 121:1383-401. 2014..CNS fungal infections are associated with considerable morbidity and mortality. To achieve good outcomes early diagnosis and early institution of appropriate therapies are the key issues. ..
- Aspergilloma of the brain: an overviewT Nadkarni
Department of Neurosurgery, Seth G S Medical College, King Edward Memorial Hospital, Parel, Mumbai, India
J Postgrad Med 51:S37-41. 2005....
- Pseudotumoral neuroparacoccidioidomycosis: one case reportVitorino Modesto dos Santos
Catholic University Medical Course and Department of Internal Medicine from HFA, Armed Forces Hospital HFA, Brasilia, DF, Brazil
Mycopathologia 166:155-8. 2008..Paracoccidioides brasiliensis was found in tissue samples collected by the lung and brain biopsies. The patient is under ambulatory surveillance and in use of trimethoprim-sulfamethoxazole...
- Zygomycetes infections in pediatric hematology oncology patients: a case series and review of the literatureWalter Dehority
Department of Pediatrics, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
J Pediatr Hematol Oncol 31:911-9. 2009..3% mortality). Survival is increasingly reported in the literature, perhaps as a result of improved diagnostic capabilities, increased physician awareness and increased reliance on adjunctive surgical therapy...
- Endoscopic endonasal surgery for biopsy of cavernous sinus lesionsH S Liu
Department of Neurosurgery, Affiliated Yu Qian Hospital of Qing Hua University, Beijing, People s Republic of China
Minim Invasive Neurosurg 52:69-73. 2009..The authors present a new application to endoscopic endonasal surgery for the biopsy of lesions arising from or invading the cavernous sinus...
- [Paracoccidioidomycosis compromising the central nervous system: a systematic review of the literature]Vinicius Sousa Pietra Pedroso
Curso de Pós Graduação em Ciências da Saúde Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG
Rev Soc Bras Med Trop 42:691-7. 2009..Thus, neuroparacoccidioidomycosis should be considered in the differential diagnosis for expansive and meningoencephalitic processes in the central nervous system, in order to establish early treatment and to avoid disabling sequelae...
- Basilar artery dissection treated by Neuroform stenting: fungal stent infectionRatul Raychaudhuri
Department of Neurological Surgery, Univesity of Texas Southwestern Medical Center, Dallas, TX 75390 8855, USA
Surg Neurol 71:477-80. 2009..However, complications associated with stenting should be taken into careful consideration. These complications include thromboembolism and stent infection...
- Neuroparacoccidioidomycosis (NPCM): magnetic resonance imaging (MRI) findingsFabiano Reis
Departamento de Radiologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126 CP 6111, 13083 887, Cidade Universitária Zeferino Vaz Campinas, SP, Brazil
Mycopathologia 175:181-6. 2013..To describe the magnetic resonance imaging (MRI) patterns of the central nervous system (CNS) involvement by neuroparacoccidioidomycosis (NPCM)...
- Laboratory investigation of fungal infections of the central nervous systemJohn A Davis
Department of Neurology, Massachusetts General Hospital, USA
Neurol India 55:233-40. 2007....
- Sinocranial aspergillosis: a form of central nervous system aspergillosis in south IndiaJ M Murthy
Department of Neurology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500 082, India
Mycoses 44:141-5. 2001....
- Neurocandidiasis: a case report and consideration of the causes of restricted diffusionDavid J Lin
Department of Radiology, Brigham and Women s Hospital, Boston, USA
J Radiol Case Rep 7:1-5. 2013..This case illustrates the value of carefully considering the causes of restricted diffusion in the brain, notably to be broader than acute stroke and to include invasive fungal infections...
- Involvement of intraocular structures in disseminated histoplasmosisMarianne Ala-Kauhaluoma
Department of Ophthalmology, Helsinki University Central Hospital, Finland
Acta Ophthalmol 88:493-6. 2010..To describe ocular involvement and response to treatment in a patient with human immunodeficiency virus (HIV) infection with severe progressive disseminated histoplasmosis (PDH)...
- Acrophialophora fusispora brain abscess in a patient with acquired immunodeficiency syndrome: a case report and review of the literatureChia Wen Li
Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital and Medical College, Tainan, Taiwan
Diagn Microbiol Infect Dis 76:368-71. 2013..Four published cases were reviewed as well...
- Radiology quiz case 1: rhinocerebral mucormycosis with cavernous sinus thrombosisShiang Fu Huang
Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan
Arch Otolaryngol Head Neck Surg 131:738, 742. 2005
- Efficacy of Abelcet and caspofungin, alone or in combination, against CNS aspergillosis in a murine modelJackie Imai
California Institute for Medical Research, San Jose, 95128, USA
J Antimicrob Chemother 56:166-71. 2005..Currently, few options exist to treat central nervous system (CNS) aspergillosis, which is usually fatal. We tested the efficacy of Abelcet and caspofungin, alone and in combination for treatment of this disease...
- Paracoccidioidomycosis case series with and without central nervous system involvementVinicius Sousa Pietra Pedroso
Programa de Pós graduação em Infectologia e Medicina Tropical, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Rev Soc Bras Med Trop 45:586-90. 2012..This paper aims to contribute to the literature describing eight cases of neuroparacoccidioidomycosis (NPMC) and compare their characteristics with patients without neurological involvement, to identify unique characteristics of NPCM...
- Invasive rhino-cerebral fungal granulomaMuralimohan Selvam
Department of Neurosurgery, Postgraduate Institute of Neurological Surgery, ALNC, VHS Medical Centre, Taramani, Chennai 600 113, India
Neurol India 58:270-6. 2010..Fungal infection of the central nervous system remains one of the most difficult diseases to treat and requires multi-modality intensive therapeutic strategies...
- In vitro interactions of amantadine hydrochloride, R-(-)-deprenyl hydrochloride and valproic acid sodium salt with antifungal agents against filamentous fungal species causing central nervous system infectionL Galgoczy
Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary
Acta Biol Hung 63:490-500. 2012..These combinations would be a basis of an effective, less toxic therapy for treatment of CNFI...
- Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasisAmy M Flattery
Department of Infectious Diseases, Merck and Co, Inc, Rahway, New Jersey, USA
Antimicrob Agents Chemother 55:3491-7. 2011..In this juvenile mouse model, caspofungin demonstrated dose-dependent activity, equivalent to or better than that of AmB at 1 mg/kg, against disseminated candidiasis with CNS involvement...
- The efficacy of voriconazole in the treatment of 192 fungal central nervous system infections: a retrospective analysisS Schwartz
Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
Infection 39:201-10. 2011..The efficacy of voriconazole against fungal central nervous system (CNS) infections was examined retrospectively...
- Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infectionSheng He Huang
Division of Infectious Diseases, The Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
PLoS ONE 7:e48570. 2012..neoformans-infected brains. Results of this study suggested that CnMVs play an important role in the pathogenesis of cryptococcal meningoencephalitis...
- Phaeohyphomycosis: a clinical-epidemiological and diagnostic study of eighteen cases in Rio Grande do Sul, BrazilCecília Bittencourt Severo
Laboratorio de Micologia, Irmandade Santa Casa de Misericórdia de Porto Alegre, RS, Brasil
Mem Inst Oswaldo Cruz 107:854-8. 2012..gloeosporioides in a lung transplant patient. The number of reported cases of phaeohyphomycosis has increased in the last decade. In a number of cases, this increased incidence may be primarily attributed to iatrogenic immunodeficiency...
- Allergic fungal sinusitis complicated by fungal brain massGeorge M Viola
Department of Medicine, Division of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Int J Infect Dis 14:e299-301. 2010..We review the epidemiology, etiology, pathophysiology, and clinical presentations of fungal sinusitis, as well as the complex management and multifaceted therapeutic modalities of AFS...
- Early fungal infection in an aortic prosthesis with probable cerebral metastasis: the success of a conservative strategyAnabela Malho Guedes
Unidade de Cuidados Intensivos Polivalente, Hospital de Santa Cruz, Lisbon, Portugal
Clin Drug Investig 33:S41-5. 2013..This case demonstrates the success of a conservative approach in a very serious fungal infection of a thoraco-abdominal aorta prosthesis...
- Neurologic complications of HIV-1 infection and its treatment in the era of antiretroviral therapySarah M Kranick
National Institutes of Health, Building 10, 6 5700, Bethesda, MD 20892, USA
Continuum (Minneap Minn) 18:1319-37. 2012..Additionally, as successful virologic control has extended the life span of patients with HIV infection, neurologists are called upon to manage long-term complications, such as neurocognitive disorders and peripheral neuropathy...
- [MR imaging in the diagnosis of primary and secondary cerebral infections]K Krope
Radiologie, Universitat Tubingen
Rofo 185:539-45. 2013..Both specific MR sequences and imaging characteristics of major cerebral infections are addressed in this overview. Furthermore, limitations and pitfalls of the method are discussed...
- [An autopsied case of zygomycosis invasing in the central nervous system and vessels, which is difficult in the differential diagnosis from aspergillosis]Asako Ueno
Department of Neurology, Faculty of Medical Science, University of Fukui
Rinsho Shinkeigaku 52:84-9. 2012..The mortality rate of CNS zygomycosis is so high that an early diagnosis of it is warranted and the start appropriate anti-fungal treatments or surgical drainage in the early stage of the disease...
- CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 2: discussion of neuro-immune reconstitution inflammatory syndrome with and without other pathogensM J D Post
Section of Neuroradiology, Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Medical Center, Miami, FL 33136, USA
AJNR Am J Neuroradiol 34:1308-18. 2013....
- Posterior fossa midline cryptococcoma in a patient with idiopathic CD4 lymphocytopeniaS Rai
Department of Microbiology, UCMS and GTB Hospital, Shalimar Bagh, Delhi, India
Indian J Med Microbiol 30:367-70. 2012..We present a case of a 50-year-old male who presented with a midline posterior fossa tumour with ICL diagnosed as cerebellar cryptococcoma...
- Management and outcomes of three cases of rhinocerebral mucormycosisStefano Viterbo
Division of Maxillofacial Surgery, Head and Neck Department, San Giovanni Battista Hospital, University of Turin, Turin, Italy
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:e69-74. 2011..This article presents and discusses the management of 3 cases of rhinocerebral mucormycosis with different onsets, progressions, and outcomes...
- Fungal infections of the central nervous systemMahan Mathur
Department of Radiology, Yale University Medical Center, New Haven, CT 06510, USA
Neuroimaging Clin N Am 22:609-32. 2012....
- [Central nervous system mycotic infections]O H Del Brutto
Departamento de Neurologia, Hospital Luis Vernaza, Guayaquil, Ecuador
Rev Neurol 30:447-59. 2000..This paper reviews current literature about these conditions, with emphasis on recent advances on diagnosis and therapy...
- The role of voriconazole in the treatment of central nervous system blastomycosisMai Ta
Southern Health Pharmacy Department, Casey Hospital, Berwick, Victoria, Australia
Ann Pharmacother 43:1696-700. 2009..Voriconazole is a broad-spectrum triazole antifungal that has emerged as a potential treatment option for CNS blastomycosis because of its excellent penetration into the cerebrospinal fluid and brain tissue...
- Central nervous system cryptococcoma in immunocompetent patients: a short review illustrated by a new caseQiang Li
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People s Republic of China
Acta Neurochir (Wien) 152:129-36. 2010..However, cryptococcal granuloma in CNS in immunocompetent patient is rare. We present one new case of cryptococcoma and review literature to illustrate diagnosis and treatment of these lesions...
- Cryptococcosis in nonhuman immunodeficiency virus-infected childrenKuan Ying Huang
Division of Pediatric Infectious Diseases, Chang Gung University, Kweishan, Taoyuan, Taiwan
Pediatr Neurol 42:267-70. 2010..Indian ink stain and cryptococcal antigen testing of cerebrospinal fluid should be performed...
- Bilateral thalamic necrosis following ingestion of ridge gourd infested with coelomycete fungi (Diplodia)Aaron de Souza
Department of Neurology, Goa Medical College, Goa 403 202, India
J Neurol Sci 295:104-6. 2010..This is the first report of neurological toxicity attributable to Diplodia in humans, and this entity should be considered in the differential diagnosis of bilateral thalamic lesions in the appropriate clinical setting...
- Cryptococcus traversal of Brain Endothelial cellsKwang Kim; Fiscal Year: 2007..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
- Plasmodium Falciparum Metal MetabolismDavid Sullivan; Fiscal Year: 2009..Plasmodium parasitism provides a comparison of "simple" erythrocyte cell to more complex infected cell. ..
- Immune reconstitution to AspergillusKieren A Marr; Fiscal Year: 2010..This information will be valuable for development of strategies to prevent and treat fungal infections in immunocompromised people. ..
- GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLSKwang Kim; Fiscal Year: 2002..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
- E. coli invasion of brain endothelial cellsKwang Kim; Fiscal Year: 2008..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
- C.elegans as a model system forC.neoformans pathogenesisEleftherios Mylonakis; Fiscal Year: 2007..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
- Genome-wide screening of E. coli for bacteremiaKwang Kim; Fiscal Year: 2007..coli bacteremia should help in development of preventive measures such as vaccines against E. coli bacteremia. [unreadable] [unreadable] [unreadable]..
- Ethanol, Tat and the Blood-brain barrierKwang Kim; Fiscal Year: 2004..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
- GENETIC & MOLECULAR BIOLOGY OF VIRULENCE IN C NEOFORMANSJohn Perfect; Fiscal Year: 2004..It is our hypothesis that beginning to understand the genetic regulation of C. neoformans during infection through this proposal will be a powerful tool to find targets to interrupt pathogenesis. ..
- E. COLI BINDING TO BRAIN ENDOTHELIAL CELLSKwang Kim; Fiscal Year: 2003....
- CRYPTOCOCCUS NEOFORMANS--A MODEL FOR PATHOGENIC FUNGIJohn Perfect; Fiscal Year: 2003..This program emphasizes a focus on a single pathogen with a basic but broad-spectrum and highly interactive genomic approach to scientific investigations which can be extrapolated to other fungi. ..
- A C.elegans high-throughput assay for the identification of new antifungal agentsEleftherios Mylonakis; Fiscal Year: 2010....