central nervous system fungal infections

Summary

Summary: MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).

Top Publications

  1. ncbi Chronic granulomatous disease presenting with disseminated intracranial aspergillosis
    Abdul Alsultan
    Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Pediatr Blood Cancer 47:107-10. 2006
  2. ncbi Imaging features of central nervous system fungal infections
    Krishan K Jain
    Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Neurol India 55:241-50. 2007
  3. ncbi Current approaches to management of cerebral fungal infection in pediatric patients with hematologic disorders
    Tomonobu Sato
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    J Pediatr Hematol Oncol 30:249-53. 2008
  4. ncbi Immunopathogenesis of central nervous system fungal infections
    John Dotis
    3rd Department of Pediatrics, Aristotle University, Hippokration Hospital, GR 54642 Thessaloniki, Greece
    Neurol India 55:216-20. 2007
  5. ncbi Activity of posaconazole in the treatment of central nervous system fungal infections
    Punnee Pitisuttithum
    Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Antimicrob Chemother 56:745-55. 2005
  6. ncbi Cerebral phaeohyphomycosis mimics high-grade astrocytoma
    Erik F Hauck
    Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8855, USA
    J Clin Neurosci 15:1061-6. 2008
  7. ncbi Multiple brain abscesses due to Penicillium spp infection
    Danilo Teixeira Noritomi
    Gastroenterology Department, Hospital das Clinicas, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil
    Rev Inst Med Trop Sao Paulo 47:167-70. 2005
  8. ncbi Management of cryptococcosis in non-HIV-related patients
    Zhirong Yao
    Department of Dermatology Xinhua Hospital, Shanghai Second Medical University, Shanghai, China
    Med Mycol 43:245-51. 2005
  9. ncbi Improved outcome in central nervous system aspergillosis, using voriconazole treatment
    Stefan Schwartz
    Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Blood 106:2641-5. 2005
  10. ncbi [Central nervous system paracoccidioidomycosis: analysis of 13 cases]
    Walter J Fagundes-Pereyra
    Clínica Neurológica e Neurocirúrgica da Santa Casa de Belo Horizonte, MG, and Centro Universitário de Vila Velha, Brazil
    Arq Neuropsiquiatr 64:269-76. 2006

Research Grants

Detail Information

Publications171 found, 100 shown here

  1. ncbi Chronic granulomatous disease presenting with disseminated intracranial aspergillosis
    Abdul Alsultan
    Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Pediatr Blood Cancer 47:107-10. 2006
    ..Whereas, optimal pharmacologic therapy is still unknown for CNS aspergillosis, voriconazole may have an advantage due to its ability to cross the blood brain barrier and excellent oral absorption and bioavailability...
  2. ncbi Imaging features of central nervous system fungal infections
    Krishan K Jain
    Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Neurol India 55:241-50. 2007
    ..The radiographic appearance alone is often not specific, but the combination of the appropriate clinical setting along with computed tomography or magnetic resonance may help to suggest the correct diagnosis...
  3. ncbi Current approaches to management of cerebral fungal infection in pediatric patients with hematologic disorders
    Tomonobu Sato
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    J Pediatr Hematol Oncol 30:249-53. 2008
    ..It is important to perform aggressive multimodality treatment, when indicated, including surgical intervention, even if in myelosuppression...
  4. ncbi Immunopathogenesis of central nervous system fungal infections
    John Dotis
    3rd Department of Pediatrics, Aristotle University, Hippokration Hospital, GR 54642 Thessaloniki, Greece
    Neurol India 55:216-20. 2007
    ....
  5. ncbi Activity of posaconazole in the treatment of central nervous system fungal infections
    Punnee Pitisuttithum
    Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Antimicrob Chemother 56:745-55. 2005
    ..In this subanalysis, we report on those subjects in this trial who had a fungal infection that involved the CNS...
  6. ncbi Cerebral phaeohyphomycosis mimics high-grade astrocytoma
    Erik F Hauck
    Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8855, USA
    J Clin Neurosci 15:1061-6. 2008
    ..Early biopsy establishing the diagnosis, followed by aggressive combined surgical and medical management is necessary for a good outcome...
  7. ncbi Multiple brain abscesses due to Penicillium spp infection
    Danilo Teixeira Noritomi
    Gastroenterology Department, Hospital das Clinicas, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil
    Rev Inst Med Trop Sao Paulo 47:167-70. 2005
    ..Penicillium spp infection caused by species other than P. marneffei normally cause only superficial or allergic disease but rare cases of invasive disease do occur. We report the fourth case of Penicillium spp CNS infection...
  8. ncbi Management of cryptococcosis in non-HIV-related patients
    Zhirong Yao
    Department of Dermatology Xinhua Hospital, Shanghai Second Medical University, Shanghai, China
    Med Mycol 43:245-51. 2005
    ..In group III, thirty-nine out of forty patients were cured without recurrence. These results indicate that the two-phase protocol was more desirable for the treatment of non-HIV associated cryptococcal infection of CNS...
  9. ncbi Improved outcome in central nervous system aspergillosis, using voriconazole treatment
    Stefan Schwartz
    Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Blood 106:2641-5. 2005
    ..We conclude from this large cohort of patients that voriconazole treatment together with neurosurgical management, whenever feasible, is currently the best approach to treat patients with CNS aspergillosis...
  10. ncbi [Central nervous system paracoccidioidomycosis: analysis of 13 cases]
    Walter J Fagundes-Pereyra
    Clínica Neurológica e Neurocirúrgica da Santa Casa de Belo Horizonte, MG, and Centro Universitário de Vila Velha, Brazil
    Arq Neuropsiquiatr 64:269-76. 2006
    ..9) months. In conclusion, the CNS involvement in paracoccidioidomycosis is more frequent and more serious than thought before. The clinical manifestations, CT scans and MRI findings are not specific of paracoccidioidomycosis...
  11. ncbi Intracranial fungal granuloma: analysis of 40 patients and review of the literature
    Arvind Dubey
    Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130 3932, USA
    Surg Neurol 63:254-60; discussion 260. 2005
    ..To describe the characteristics of patients diagnosed with intracranial fungal granuloma (IFG) in the largest reported series to date (to our knowledge)...
  12. ncbi Isolated primary intracerebral mycetoma: presenting as a mass lesion in a patient with prostate cancer and multiple myeloma
    Shyam Prabhakaran
    Department of Neurology and Neuroscience, New York Presbyterian Hospital Weill Medical Center of Cornell University, USA
    J Neurooncol 71:49-52. 2005
    ..A brief review of the literature discusses the rarity, presentation, diagnosis, and management of primary intracerebral mycetomas...
  13. ncbi Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathy
    Peterus Thajeb
    Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan, ROC
    Scand J Infect Dis 36:643-8. 2004
    ..To improve outcome, a combination of early radical debridement, ocular exenteration, parenteral and local administration of amphotericin B, and decompression craniotomy should be considered...
  14. ncbi Unsuccessful treatment with voriconazole of a brain abscess due to Cladophialophora bantiana
    Alberto Fica
    Sección Infectología, Hospital Clinico U de Chile, Santiago, Chile
    Scand J Infect Dis 35:892-3. 2003
    ..We report a case of CNS infection in this agent unsuccessfully treated by surgery and various antifungal compounds including high doses of voriconazole (6 mg/kg bid). No adverse effects related to this compound were observed...
  15. ncbi [Histoplasmoma as isolated central nervous system lesion in an immunocompetent patient]
    Emerson L Gasparetto
    Serviço de Radiologia Médica e Diagnóstico por Imagem, Hospital de Clinicas, Universidade Federal do Parana, Curitiba, PR, Brazil
    Arq Neuropsiquiatr 63:689-92. 2005
    ..The stereotactic biopsy was performed and the histological diagnosis of histoplasmosis was defined. The treatment was initiated with fluconazole. The patient showed important clinical improvement after 6 months...
  16. ncbi Successful treatment with voriconazole of fungal cerebral abscess due to Cladophialophora bantiana
    Mark K Lyons
    Department of Neurological Surgery, Mayo Clinic Scottsdale, Mayo Clinic College of Medicine, 13600 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Clin Neurol Neurosurg 107:532-4. 2005
    ..bantiana fungal infections have become more common in recent years. Aggressive and continuous treatment with voriconazole may offer an improved chance of survival in these patients...
  17. pmc Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis
    Karl V Clemons
    California Institute for Medical Research, Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Ave, San Jose, California 95128 2699, USA
    Antimicrob Agents Chemother 49:4867-75. 2005
    ..These results indicate that AmBi in combination with VCZ may be superior for treatment of CNS aspergillosis; combinations of AmBi and MICA or CAS were not antagonistic and may have a slight benefit...
  18. ncbi Fungal brain infections
    Eileen P Scully
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 21:347-52. 2008
    ....
  19. ncbi Cerebral blastomycosis: a case report
    Bal Chander
    Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi
    Indian J Pathol Microbiol 50:821-4. 2007
    ..Only two cases of intracranial extra-axial blastomycosis have been reported from India, and we report the third case, which presented as meningioma in a 23-year old female...
  20. ncbi Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection
    Carolina Serena
    Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain
    J Antimicrob Chemother 60:162-5. 2007
    ..We studied the efficacy of voriconazole compared with amphotericin B in a murine model of central nervous system infection by Cryptococcus neoformans. Infection was established intracerebrally...
  21. ncbi Fungal infections of the CNS: treatment strategies for the immunocompromised patient
    Katharine E Black
    Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA
    CNS Drugs 21:293-318. 2007
    ..Effective treatment requires a definitive diagnosis, which is often challenging in the population at risk of CNS fungal infections...
  22. ncbi Cerebral blastomycosis: a case series incorporating voriconazole in the treatment regimen
    Sergio M Borgia
    William Osler Health Centre, Ontario, Canada
    Med Mycol 44:659-64. 2006
    ....
  23. pmc Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis
    Caitlin Reed
    Antimicrob Agents Chemother 50:3968-9. 2006
  24. ncbi Aspergillus brain abscess in a patient with acute myeloid leukaemia successfully treated with voriconazole
    F Wandroo
    Department of Haematology, Sandwell and West Birmingham Hospital, Lyndon Road, West Bromwich, West Midlands B714HJ, UK
    Clin Lab Haematol 28:130-3. 2006
    ..These newer azoles may change the outlook of this fatal condition. We report here a patient with cerebral aspergillosis who was successfully treated with voriconazole...
  25. ncbi Mucormycosis presenting with painful ophthalmoplegia
    B Karakurum
    Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Department of Neurology, Adana, Turkey
    Acta Neurol Belg 105:201-5. 2005
    ..The possibility of mucormycosis should be investigated in any patient with painful ophthalmoplegia, and prompt otorhinolaryngologic examination is recommended to ensure rapid diagnosis and treatment...
  26. ncbi Primary central nervous system phaeohyphomycosis: a review of 101 cases
    Sanjay G Revankar
    Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    Clin Infect Dis 38:206-16. 2004
    ..Complete excision of brain lesions may provide better results than simple aspiration. An aggressive medical and surgical approach is warranted in treating these infections to optimize outcomes...
  27. ncbi Antifungal therapy for central nervous system histoplasmosis, using a newly developed intracranial model of infection
    Ross R Haynes
    Histoplasmosis Reference Laboratory, Department of Medicine, Indiana University School of Medicine, 1001 W 10th Street, OPW 430, Indianapolis, IN 46202 2879, USA
    J Infect Dis 185:1830-2. 2002
    ..The hypothesis that amphotericin B-fluconazole combination therapy would be superior to amphotericin B monotherapy for treatment of CNS histoplasmosis was not supported by this study...
  28. ncbi CNS-aspergillosis: are there new treatment options?
    S Schwartz
    Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Freie Universitat, Hindenburgdamm 30, D 12200 Berlin, Germany
    Mycoses 46:8-14. 2003
    ..However, additional clinical data are needed to determine more precisely the role of voriconazole in CNS aspergillosis. In this review, we have compiled the available pharmacological and clinical data on CNS aspergillosis...
  29. ncbi Cryptococcosis of the central nervous system in a dog
    Therese E O'Toole
    Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    J Am Vet Med Assoc 222:1722-5, 1706. 2003
    ..Monitoring serum latex agglutination test results may provide a safe, less invasive means of monitoring response to treatment...
  30. ncbi [Invasive rhinocerebral aspergillosis occurred during myelosuppressive phase after chemotherapy: a case report and literature review]
    Z Yu
    HSCT Center, Affiliated Hospital of Academy of Military Medical Science, Beijing 100039, China
    Zhonghua Xue Ye Xue Za Zhi 22:366-9. 2001
    ..CONCLUSION: For most of the IRA, there remains no effective treatment. The best treatment is AmB in combination with surgical excision...
  31. ncbi Cerebral phaeohyphomycosis masquerading as a parafalcian mass: case report
    Hooshang Saberi
    Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Surg Neurol 60:354-9; discussion 359. 2003
    ..Cerebral phaeohyphomycosis caused by Fonsecaea pedrosoi is a rarity. However, about four cases have been reported in the literature. The disease remains mostly fatal despite employment of new treatment modalities...
  32. ncbi [Central nervous system involvement by histoplasmosis as the unique manifestation of this disease in immunocompetent patients: presentation of two cases]
    Guido C Levi
    Serviço de Moléstias Infecciosas, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, Sao Paulo, SP, Brasil
    Arq Neuropsiquiatr 61:859-63. 2003
    ..Comments about the diversity of clinical presentation and main differential diagnosis are presented. We analyze the serologic and cerebrospinal fluid results and, finally, discuss the drugs and duration of treatment...
  33. ncbi Cerebellar aspergillosis in an infant: case report
    Sandeep Mohindra
    Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Neurosurgery 58:E587; discussion E587. 2006
    ..Immunocompetent patients harboring invasive intracranial fungal infections still remain an elusive diagnosis...
  34. ncbi Bacterial meningitis and other nonviral infections of the nervous system
    Thomas P Bleck
    Rush Medical College, Rush University Medical Center, 600 South Paulina Street, 544 AF, Chicago, IL 60612, USA Electronic address
    Crit Care Clin 29:975-87. 2013
    ....
  35. ncbi Central nervous system fungal infections in tropics
    N Khandelwal
    Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Neuroimaging Clin N Am 21:859-66, viii. 2011
    ..must have high degree of suspicion in immunocompromised patients regarding the possibility of central nervous system fungal infections and keep in mind the appearances of various fungi even when immune response is intact...
  36. ncbi Intraventricular cryptococcal cysts masquerading as racemose neurocysticercosis
    Marlon Mathews
    Department of Neurosurgery, University of California, Irvine, Orange, CA 92868
    Surg Neurol 67:647-9. 2007
    ..We report a case in which intraventricular cryptococcal cysts clinically and radiologically simulated the racemose form of neurocysticercosis...
  37. ncbi Unusual complications and presentations of intracranial abscess: experience of a single institution
    Hasan Kocaeli
    Department of Neurosurgery, Uludag University School of Medicine, Gorukle Campus, Bursa 16059, Turkey
    Surg Neurol 69:383-91; discussion 391. 2008
    ..This study was undertaken to shed light on the unusual complications and presentations of intracranial abscess treated at a single institution...
  38. pmc Neuroimaging of infections
    Oliver Kastrup
    Department of Neurology, University Duisburg Essen, 45122 Essen, Germany
    NeuroRx 2:324-32. 2005
    ..In patients with herpes simplex and more exotic viruses like West Nile and Murray Valley virus DWI allows earlier lesion detection and therapeutic intervention with virustatic drugs...
  39. ncbi Successful treatment of a giant isolated cerebral mucormycotic (zygomycotic) abscess using endoscopic debridement: case report and therapeutic considerations
    Philippe Metellus
    Départamentes de Neurochirurgie, Hopital Timone, Marseille, France
    Surg Neurol 69:510-5; discussion 515. 2008
    ..Cerebral mucormycosis without rhino-orbital or systemic involvement is an extremely rare condition mostly associated with parenteral drug abuse...
  40. ncbi MRI with Magnetic Resonance Spectroscopy of multiple brain abscesses secondary to Scedosporium apiospermum in two immunocompromised patients
    H Wayne Slone
    The Ohio State University, Department of Radiology, Columbus, OH 43210, USA
    Clin Imaging 37:361-6. 2013
    ..In the appropriate clinical setting, conventional MR imaging and MR spectroscopy may facilitate diagnosis, earlier initiation of antifungal pharmacotherapy and surgical intervention in this frequently fatal infection...
  41. ncbi Iatrogenic fungal infections of central nervous system
    Sourabh Lahoti
    Department of Neurology, University of Kentucky College of Medicine, Room L 445, Kentucky Clinic, Lexington, KY, 40515, USA
    Curr Neurol Neurosci Rep 13:399. 2013
    ..rostratum infection. The current therapeutic recommendation is a 6 mg/kg dose of voriconazole every 12 h followed by liposomal amphotericin B. In some instances, surgical debridement and drainage may be necessary...
  42. ncbi Fungal infections of the nervous system: current perspective and controversies in management
    Rewati Raman Sharma
    National Neurosurgical Centre, Khoula Hospital, PO Box 90, Postal Code 116, Muscat, Oman
    Int J Surg 8:591-601. 2010
    ..Now evidence based data are gathering together in favor of their usefulness in the management of invasive fungal infections. But still, many questions are unanswered and controversies persist relating to their selection and use...
  43. ncbi Cerebral phaeohyphomycosis caused by Cladosporium spp. in two domestic shorthair cats
    Christopher L Mariani
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Health Science Center, University of Florida, Gainesville 32610 0126, USA
    J Am Anim Hosp Assoc 38:225-30. 2002
    ..Euthanasia was performed in both cats, and postmortem diagnoses of phaeohyphomycosis secondary to Cladosporium spp. were made based on histopathology and fungal culture in both cats...
  44. ncbi Cure of ventriculitis and central nervous system shunt infection by Staphylococcus epidermidis with vancomycin by intraventricular injection in a liver transplant recipient
    M Schwabe
    Department of Hematology and Oncology, Univerity of Freiburg Medical Center, Freiburg, Germany
    Transpl Infect Dis 9:46-50. 2007
    ..Intraventricular injection of vancomycin is an effective and safe procedure to eradicate S. epidermidis from the central nervous system when i.v. vancomycin treatment fails...
  45. ncbi Cure of disseminated zygomycosis with cerebral involvement using high dose liposomal amphotericin B and surgery
    Sanjay G Revankar
    Wayne State University, Harper University Hospital, Detroit, Michigan 48201, USA
    Med Mycol 45:183-5. 2007
    ..Since penetration of the central nervous system by amphotericin B is poor the application of high dose therapy may be useful in cases of cerebral zygomycosis...
  46. ncbi Co-infection of HIV and tropical infectious agents that affect the nervous system
    L Chimelli
    Division of Pathology, National Institute of Cancer, Rua Cordeiro da Graça 156, Santo Cristo, Rio de Janeiro, RJ, CEP 20220 400, Brazil
    Rev Neurol (Paris) 168:270-82. 2012
    ..This article reviews some of the key diagnostic aspects of tropical infections associated with HIV infection...
  47. ncbi Disseminated Cladophialophora bantiana infection in a heart transplant recipient
    Andreas Keyser
    Department of Cardiothoracic Surgery, University Hospital of Regensburg, Regensburg, Germany
    J Heart Lung Transplant 21:503-5. 2002
    ..We report the case of a heart transplant recipient with cutaneous, cerebral, and lung manifestation of Cladophialophora bantiana who died despite surgical and systemic, high-dosage itraconazole treatment...
  48. ncbi Immunotherapy for fungal infections with special emphasis on central nervous system infections
    Iyer G Parameswaran
    Division of Infectious Diseases, University at Buffalo School of Medicine, Buffalo, NY, USA
    Neurol India 55:260-6. 2007
    ..This notion is only partially accurate. Immune-based therapies for fungal CNS disease are at an exploratory level and merit further evaluation in clinical trials...
  49. ncbi Mortality risk factors in patients with zygomycosis: a retrospective and multicentre study of 25 cases
    Andreu Llorente
    Servicio de Hematologia, Hospital Joan XXIII, IISPV, Tarragona, Spain
    Enferm Infecc Microbiol Clin 29:263-8. 2011
    ..To investigate mortality risk factors in patients with zygomycosis...
  50. ncbi Long-term outcome of neuroparacoccidioidomycosis treatment
    Fabio Francesconi
    Dermatology Department, Manaus Oncology Control Foundation Center, Manaus, AM, Brazil
    Rev Soc Bras Med Trop 44:22-5. 2011
    ..NPCM has been described sporadically in some case reports and small case series, with little or no focus on treatment outcome and long-term follow-up...
  51. ncbi Long-term risk of atypical fungal infection after near-drowning episodes
    Christian Garzoni
    Pediatrics 119:417; author reply 417-8. 2007
  52. ncbi [Cerebral candidiasis in a neonate]
    M Mata Jorge
    An Pediatr (Barc) 58:194-5. 2003
  53. ncbi Disseminated zygomycosis due to Mycocladus corymbifera with cutaneous and cerebral involvement
    Clare Schofield
    Departments of Dermatology Neurosurgery, Royal Hobart Hospital, Hobart, Tasmania, Australia
    Australas J Dermatol 54:e8-11. 2013
    ..The skin lesions played a significant role in the diagnosis of mucormycosis. These infections have an exceedingly high mortality rate and early recognition of cutaneous lesions is essential to successful management...
  54. ncbi Recurrent blastomycosis of the central nervous system: case report and review
    A Chowfin
    University of North Dakota School of Medicine, Fargo, ND 58122, USA
    Clin Infect Dis 30:969-71. 2000
    ..This treatment may be an alternate approach for management of similar cases...
  55. ncbi Brain abscess caused by Cladophialophora (Xylohypha) bantiana in a renal transplant patient
    E R Silveira
    Department of Nephrology, Hospital Vera Cruz, Federal University of Minas Gerais, Avenida Barbacena 653, 30190 130 Belo Horizonte, Minas Gerais, Brazil
    Transpl Infect Dis 5:104-7. 2003
    ..Ten days later the patient's blood cultures became positive for Escherichia coli. After 3 days the patient died due to septic shock...
  56. pmc Long term survival of patient with invasive aspergillosis involving orbit, paranasal sinus, and central nervous system
    K Kusaka
    Br J Ophthalmol 87:791-2. 2003
  57. ncbi A patient with new-onset seizure and mediastinal adenopathy
    Mylene T Truong
    Department of Diagnostic Radiology, Box 57, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Chest 126:982-5. 2004
  58. ncbi Aspergillosis of the central nervous system: a catastrophic opportunistic infection
    Piya Pongbhaesaj
    Division of Neurology, Department of Medicine, Faculty of Medicine at Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 35:119-25. 2004
    ..It remains a catastrophic opportunistic infection in spite of the current intensive and aggressive treatment...
  59. ncbi Concomitant diabetic ketoacidosis and rhinocerebral mucormycosis: report of a case
    Bing Yin Shi
    Department of Endocrinology, First Hospital of Xi an Jiaotong University, 710061, China
    Chin Med J (Engl) 117:1113-5. 2004
  60. ncbi Brain stem candidiasis mimicking cerebellopontine angle tumor
    Xin yu Hong
    Neurosurgery Department, First Hospital of Ji Lin University, Chang Chun, China
    Surg Neurol 70:87-91. 2008
    ..Infectious process can mimic cerebral tumors. We present the first report of a fugal infection in brainstem mimicking cerebral tumors in the literature...
  61. ncbi Central nervous system involvement in cryptococcal infection in individuals after solid organ transplantation or with AIDS
    J A Davis
    Transplant Infectious Disease Program, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Transpl Infect Dis 11:432-7. 2009
    ..Cryptococcus neoformans is an important pathogen of immunocompromised hosts. Manifestations of cryptococcal infection have not been compared between populations based on the nature of the underlying immune deficiencies...
  62. ncbi Aspiration cytology of brain abscess from a fatal case of cerebral phaeohyphomycosis due to Ramichloridium mackenziei
    Samir S Amr
    Pathology Services Division, Dhahran Health Center, Saudi Aramco Medical Services Organization, Saudi Aramco, Dhahran, Saudi Arabia
    Diagn Cytopathol 35:695-9. 2007
    ..She was on long-term corticosteroid therapy. The patient developed rapidly progressive multiple brain abscesses and died despite aspiration of the abscess and administration of intravenous amphotericin B lipid complex and voriconazole...
  63. ncbi Onyx embolization for the endovascular treatment of infectious and traumatic aneurysms involving the cranial and cerebral vasculature
    Ashutosh P Jadhav
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurointerv Surg 5:562-5. 2013
    ..Onyx is a liquid non-adhesive viscous embolic agent ideal for slow targeted injections which is currently approved for the treatment of intracranial aneurysms and arteriovenous malformations...
  64. ncbi Cerebral cryptococcosis: atypical appearances on CT
    M Awasthi
    Department of Radiology, King Edward VII Memorial Hospital, Acharya Donde Marg, Parel, Bombay, India
    Br J Radiol 74:83-5. 2001
    ..We report an unusual presentation of cryptococcal infection in an immunocompetent patient presenting with headache and hemiplegia. CT demonstrated a large ring-enhancing lesion in the parietal region with intralesional calcification...
  65. ncbi Cryptococcosis
    John R Perfect
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, PO Box 3353, Durham, NC 27710, USA
    Infect Dis Clin North Am 16:837-74, v-vi. 2002
    ..This article collates and analyzes both new and old knowledge about the pathogen to help frame the meaning of human cryptococcosis as it starts to evolve in the new millennium...
  66. ncbi Fungal infections of the central nervous system
    J M K Murthy
    Continental Institute of Neurosciences and Rehabilitation, Continental Hospitals, IT and Financial District, Gachibowli, Hyderabad, India Electronic address
    Handb Clin Neurol 121:1383-401. 2014
    ..CNS fungal infections are associated with considerable morbidity and mortality. To achieve good outcomes early diagnosis and early institution of appropriate therapies are the key issues. ..
  67. ncbi Aspergilloma of the brain: an overview
    T Nadkarni
    Department of Neurosurgery, Seth G S Medical College, King Edward Memorial Hospital, Parel, Mumbai, India
    J Postgrad Med 51:S37-41. 2005
    ....
  68. ncbi Pseudotumoral neuroparacoccidioidomycosis: one case report
    Vitorino Modesto dos Santos
    Catholic University Medical Course and Department of Internal Medicine from HFA, Armed Forces Hospital HFA, Brasilia, DF, Brazil
    Mycopathologia 166:155-8. 2008
    ..Paracoccidioides brasiliensis was found in tissue samples collected by the lung and brain biopsies. The patient is under ambulatory surveillance and in use of trimethoprim-sulfamethoxazole...
  69. ncbi Zygomycetes infections in pediatric hematology oncology patients: a case series and review of the literature
    Walter Dehority
    Department of Pediatrics, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    J Pediatr Hematol Oncol 31:911-9. 2009
    ..3% mortality). Survival is increasingly reported in the literature, perhaps as a result of improved diagnostic capabilities, increased physician awareness and increased reliance on adjunctive surgical therapy...
  70. ncbi Endoscopic endonasal surgery for biopsy of cavernous sinus lesions
    H S Liu
    Department of Neurosurgery, Affiliated Yu Qian Hospital of Qing Hua University, Beijing, People s Republic of China
    Minim Invasive Neurosurg 52:69-73. 2009
    ..The authors present a new application to endoscopic endonasal surgery for the biopsy of lesions arising from or invading the cavernous sinus...
  71. ncbi [Paracoccidioidomycosis compromising the central nervous system: a systematic review of the literature]
    Vinicius Sousa Pietra Pedroso
    Curso de Pós Graduação em Ciências da Saúde Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG
    Rev Soc Bras Med Trop 42:691-7. 2009
    ..Thus, neuroparacoccidioidomycosis should be considered in the differential diagnosis for expansive and meningoencephalitic processes in the central nervous system, in order to establish early treatment and to avoid disabling sequelae...
  72. ncbi Basilar artery dissection treated by Neuroform stenting: fungal stent infection
    Ratul Raychaudhuri
    Department of Neurological Surgery, Univesity of Texas Southwestern Medical Center, Dallas, TX 75390 8855, USA
    Surg Neurol 71:477-80. 2009
    ..However, complications associated with stenting should be taken into careful consideration. These complications include thromboembolism and stent infection...
  73. ncbi Neuroparacoccidioidomycosis (NPCM): magnetic resonance imaging (MRI) findings
    Fabiano Reis
    Departamento de Radiologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo, 126 CP 6111, 13083 887, Cidade Universitária Zeferino Vaz Campinas, SP, Brazil
    Mycopathologia 175:181-6. 2013
    ..To describe the magnetic resonance imaging (MRI) patterns of the central nervous system (CNS) involvement by neuroparacoccidioidomycosis (NPCM)...
  74. ncbi Laboratory investigation of fungal infections of the central nervous system
    John A Davis
    Department of Neurology, Massachusetts General Hospital, USA
    Neurol India 55:233-40. 2007
    ....
  75. ncbi Sinocranial aspergillosis: a form of central nervous system aspergillosis in south India
    J M Murthy
    Department of Neurology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500 082, India
    Mycoses 44:141-5. 2001
    ....
  76. pmc Neurocandidiasis: a case report and consideration of the causes of restricted diffusion
    David J Lin
    Department of Radiology, Brigham and Women s Hospital, Boston, USA
    J Radiol Case Rep 7:1-5. 2013
    ..This case illustrates the value of carefully considering the causes of restricted diffusion in the brain, notably to be broader than acute stroke and to include invasive fungal infections...
  77. ncbi Involvement of intraocular structures in disseminated histoplasmosis
    Marianne Ala-Kauhaluoma
    Department of Ophthalmology, Helsinki University Central Hospital, Finland
    Acta Ophthalmol 88:493-6. 2010
    ..To describe ocular involvement and response to treatment in a patient with human immunodeficiency virus (HIV) infection with severe progressive disseminated histoplasmosis (PDH)...
  78. ncbi Acrophialophora fusispora brain abscess in a patient with acquired immunodeficiency syndrome: a case report and review of the literature
    Chia Wen Li
    Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital and Medical College, Tainan, Taiwan
    Diagn Microbiol Infect Dis 76:368-71. 2013
    ..Four published cases were reviewed as well...
  79. ncbi Radiology quiz case 1: rhinocerebral mucormycosis with cavernous sinus thrombosis
    Shiang Fu Huang
    Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan
    Arch Otolaryngol Head Neck Surg 131:738, 742. 2005
  80. ncbi Efficacy of Abelcet and caspofungin, alone or in combination, against CNS aspergillosis in a murine model
    Jackie Imai
    California Institute for Medical Research, San Jose, 95128, USA
    J Antimicrob Chemother 56:166-71. 2005
    ..Currently, few options exist to treat central nervous system (CNS) aspergillosis, which is usually fatal. We tested the efficacy of Abelcet and caspofungin, alone and in combination for treatment of this disease...
  81. ncbi Paracoccidioidomycosis case series with and without central nervous system involvement
    Vinicius Sousa Pietra Pedroso
    Programa de Pós graduação em Infectologia e Medicina Tropical, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Rev Soc Bras Med Trop 45:586-90. 2012
    ..This paper aims to contribute to the literature describing eight cases of neuroparacoccidioidomycosis (NPMC) and compare their characteristics with patients without neurological involvement, to identify unique characteristics of NPCM...
  82. ncbi Invasive rhino-cerebral fungal granuloma
    Muralimohan Selvam
    Department of Neurosurgery, Postgraduate Institute of Neurological Surgery, ALNC, VHS Medical Centre, Taramani, Chennai 600 113, India
    Neurol India 58:270-6. 2010
    ..Fungal infection of the central nervous system remains one of the most difficult diseases to treat and requires multi-modality intensive therapeutic strategies...
  83. ncbi In vitro interactions of amantadine hydrochloride, R-(-)-deprenyl hydrochloride and valproic acid sodium salt with antifungal agents against filamentous fungal species causing central nervous system infection
    L Galgoczy
    Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary
    Acta Biol Hung 63:490-500. 2012
    ..These combinations would be a basis of an effective, less toxic therapy for treatment of CNFI...
  84. pmc Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis
    Amy M Flattery
    Department of Infectious Diseases, Merck and Co, Inc, Rahway, New Jersey, USA
    Antimicrob Agents Chemother 55:3491-7. 2011
    ..In this juvenile mouse model, caspofungin demonstrated dose-dependent activity, equivalent to or better than that of AmB at 1 mg/kg, against disseminated candidiasis with CNS involvement...
  85. ncbi The efficacy of voriconazole in the treatment of 192 fungal central nervous system infections: a retrospective analysis
    S Schwartz
    Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Infection 39:201-10. 2011
    ..The efficacy of voriconazole against fungal central nervous system (CNS) infections was examined retrospectively...
  86. pmc Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection
    Sheng He Huang
    Division of Infectious Diseases, The Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 7:e48570. 2012
    ..neoformans-infected brains. Results of this study suggested that CnMVs play an important role in the pathogenesis of cryptococcal meningoencephalitis...
  87. ncbi Phaeohyphomycosis: a clinical-epidemiological and diagnostic study of eighteen cases in Rio Grande do Sul, Brazil
    Cecília Bittencourt Severo
    Laboratorio de Micologia, Irmandade Santa Casa de Misericórdia de Porto Alegre, RS, Brasil
    Mem Inst Oswaldo Cruz 107:854-8. 2012
    ..gloeosporioides in a lung transplant patient. The number of reported cases of phaeohyphomycosis has increased in the last decade. In a number of cases, this increased incidence may be primarily attributed to iatrogenic immunodeficiency...
  88. ncbi Allergic fungal sinusitis complicated by fungal brain mass
    George M Viola
    Department of Medicine, Division of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Int J Infect Dis 14:e299-301. 2010
    ..We review the epidemiology, etiology, pathophysiology, and clinical presentations of fungal sinusitis, as well as the complex management and multifaceted therapeutic modalities of AFS...
  89. ncbi Early fungal infection in an aortic prosthesis with probable cerebral metastasis: the success of a conservative strategy
    Anabela Malho Guedes
    Unidade de Cuidados Intensivos Polivalente, Hospital de Santa Cruz, Lisbon, Portugal
    Clin Drug Investig 33:S41-5. 2013
    ..This case demonstrates the success of a conservative approach in a very serious fungal infection of a thoraco-abdominal aorta prosthesis...
  90. pmc Neurologic complications of HIV-1 infection and its treatment in the era of antiretroviral therapy
    Sarah M Kranick
    National Institutes of Health, Building 10, 6 5700, Bethesda, MD 20892, USA
    Continuum (Minneap Minn) 18:1319-37. 2012
    ..Additionally, as successful virologic control has extended the life span of patients with HIV infection, neurologists are called upon to manage long-term complications, such as neurocognitive disorders and peripheral neuropathy...
  91. ncbi [MR imaging in the diagnosis of primary and secondary cerebral infections]
    K Krope
    Radiologie, Universitat Tubingen
    Rofo 185:539-45. 2013
    ..Both specific MR sequences and imaging characteristics of major cerebral infections are addressed in this overview. Furthermore, limitations and pitfalls of the method are discussed...
  92. ncbi [An autopsied case of zygomycosis invasing in the central nervous system and vessels, which is difficult in the differential diagnosis from aspergillosis]
    Asako Ueno
    Department of Neurology, Faculty of Medical Science, University of Fukui
    Rinsho Shinkeigaku 52:84-9. 2012
    ..The mortality rate of CNS zygomycosis is so high that an early diagnosis of it is warranted and the start appropriate anti-fungal treatments or surgical drainage in the early stage of the disease...
  93. ncbi CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 2: discussion of neuro-immune reconstitution inflammatory syndrome with and without other pathogens
    M J D Post
    Section of Neuroradiology, Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Medical Center, Miami, FL 33136, USA
    AJNR Am J Neuroradiol 34:1308-18. 2013
    ....
  94. ncbi Posterior fossa midline cryptococcoma in a patient with idiopathic CD4 lymphocytopenia
    S Rai
    Department of Microbiology, UCMS and GTB Hospital, Shalimar Bagh, Delhi, India
    Indian J Med Microbiol 30:367-70. 2012
    ..We present a case of a 50-year-old male who presented with a midline posterior fossa tumour with ICL diagnosed as cerebellar cryptococcoma...
  95. ncbi Management and outcomes of three cases of rhinocerebral mucormycosis
    Stefano Viterbo
    Division of Maxillofacial Surgery, Head and Neck Department, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:e69-74. 2011
    ..This article presents and discusses the management of 3 cases of rhinocerebral mucormycosis with different onsets, progressions, and outcomes...
  96. ncbi Fungal infections of the central nervous system
    Mahan Mathur
    Department of Radiology, Yale University Medical Center, New Haven, CT 06510, USA
    Neuroimaging Clin N Am 22:609-32. 2012
    ....
  97. ncbi [Central nervous system mycotic infections]
    O H Del Brutto
    Departamento de Neurologia, Hospital Luis Vernaza, Guayaquil, Ecuador
    Rev Neurol 30:447-59. 2000
    ..This paper reviews current literature about these conditions, with emphasis on recent advances on diagnosis and therapy...
  98. ncbi The role of voriconazole in the treatment of central nervous system blastomycosis
    Mai Ta
    Southern Health Pharmacy Department, Casey Hospital, Berwick, Victoria, Australia
    Ann Pharmacother 43:1696-700. 2009
    ..Voriconazole is a broad-spectrum triazole antifungal that has emerged as a potential treatment option for CNS blastomycosis because of its excellent penetration into the cerebrospinal fluid and brain tissue...
  99. ncbi Central nervous system cryptococcoma in immunocompetent patients: a short review illustrated by a new case
    Qiang Li
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People s Republic of China
    Acta Neurochir (Wien) 152:129-36. 2010
    ..However, cryptococcal granuloma in CNS in immunocompetent patient is rare. We present one new case of cryptococcoma and review literature to illustrate diagnosis and treatment of these lesions...
  100. ncbi Cryptococcosis in nonhuman immunodeficiency virus-infected children
    Kuan Ying Huang
    Division of Pediatric Infectious Diseases, Chang Gung University, Kweishan, Taoyuan, Taiwan
    Pediatr Neurol 42:267-70. 2010
    ..Indian ink stain and cryptococcal antigen testing of cerebrospinal fluid should be performed...
  101. ncbi Bilateral thalamic necrosis following ingestion of ridge gourd infested with coelomycete fungi (Diplodia)
    Aaron de Souza
    Department of Neurology, Goa Medical College, Goa 403 202, India
    J Neurol Sci 295:104-6. 2010
    ..This is the first report of neurological toxicity attributable to Diplodia in humans, and this entity should be considered in the differential diagnosis of bilateral thalamic lesions in the appropriate clinical setting...

Research Grants13

  1. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
  2. Plasmodium Falciparum Metal Metabolism
    David Sullivan; Fiscal Year: 2009
    ..Plasmodium parasitism provides a comparison of "simple" erythrocyte cell to more complex infected cell. ..
  3. Immune reconstitution to Aspergillus
    Kieren A Marr; Fiscal Year: 2010
    ..This information will be valuable for development of strategies to prevent and treat fungal infections in immunocompromised people. ..
  4. GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2002
    ..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
  5. E. coli invasion of brain endothelial cells
    Kwang Kim; Fiscal Year: 2008
    ..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
  6. C.elegans as a model system forC.neoformans pathogenesis
    Eleftherios Mylonakis; Fiscal Year: 2007
    ..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
  7. Genome-wide screening of E. coli for bacteremia
    Kwang Kim; Fiscal Year: 2007
    ..coli bacteremia should help in development of preventive measures such as vaccines against E. coli bacteremia. [unreadable] [unreadable] [unreadable]..
  8. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
  9. GENETIC & MOLECULAR BIOLOGY OF VIRULENCE IN C NEOFORMANS
    John Perfect; Fiscal Year: 2004
    ..It is our hypothesis that beginning to understand the genetic regulation of C. neoformans during infection through this proposal will be a powerful tool to find targets to interrupt pathogenesis. ..
  10. E. COLI BINDING TO BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2003
    ....
  11. CRYPTOCOCCUS NEOFORMANS--A MODEL FOR PATHOGENIC FUNGI
    John Perfect; Fiscal Year: 2003
    ..This program emphasizes a focus on a single pathogen with a basic but broad-spectrum and highly interactive genomic approach to scientific investigations which can be extrapolated to other fungi. ..
  12. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ....