central nervous system infections

Summary

Summary: Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.

Top Publications

  1. pmc Role of microglia in central nervous system infections
    R Bryan Rock
    Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, and University of Minnesota Medical School, USA
    Clin Microbiol Rev 17:942-64, table of contents. 2004
  2. pmc The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam
    Walter R Taylor
    Oxford University Clinical Research Unit, Hanoi, Vietnam
    PLoS ONE 7:e42099. 2012
  3. pmc Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections
    Le Van Tan
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, South East Asia Infectious Diseases Clinical Research Network, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    MBio 4:e00231-13. 2013
  4. pmc Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans
    Kiem Vu
    Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA
    Eukaryot Cell 8:1803-7. 2009
  5. pmc Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells
    Min Long
    Department of Microbiology, Southern Medical University, Guangzhou, China
    J Biomed Sci 19:19. 2012
  6. pmc CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Virol 86:2416-27. 2012
  7. ncbi Central nervous system infections in immunocompromised patients: update on diagnostics and therapy
    Martin Schmidt-Hieber
    Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Leuk Lymphoma 50:24-36. 2009
  8. pmc Aetiologies of central nervous system infection in Viet Nam: a prospective provincial hospital-based descriptive surveillance study
    Nghia Ho Dang Trung
    Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam
    PLoS ONE 7:e37825. 2012
  9. pmc Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections
    Roland Nau
    Department of Geriatrics, Evangelisches Krankenhaus Göttingen Weende, An der Lutter 24, D 37075 Gottingen, Germany
    Clin Microbiol Rev 23:858-83. 2010
  10. ncbi The medical management of central nervous system infections in Uganda and the potential impact of an algorithm-based approach to improve outcomes
    Joel D Trachtenberg
    Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84124, USA
    Int J Infect Dis 11:524-30. 2007

Detail Information

Publications229 found, 100 shown here

  1. pmc Role of microglia in central nervous system infections
    R Bryan Rock
    Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, and University of Minnesota Medical School, USA
    Clin Microbiol Rev 17:942-64, table of contents. 2004
    ..It is proposed that an enhanced understanding of microglia will yield improved therapies of central nervous system infections, since such therapies are, by and large, sorely needed.
  2. pmc The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam
    Walter R Taylor
    Oxford University Clinical Research Unit, Hanoi, Vietnam
    PLoS ONE 7:e42099. 2012
    ..To determine prospectively the causative pathogens of central nervous system (CNS) infections in patients admitted to a tertiary referral hospital in Hanoi, Vietnam...
  3. pmc Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections
    Le Van Tan
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, South East Asia Infectious Diseases Clinical Research Network, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    MBio 4:e00231-13. 2013
    ..Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus...
  4. pmc Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans
    Kiem Vu
    Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA
    Eukaryot Cell 8:1803-7. 2009
    ..Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection...
  5. pmc Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells
    Min Long
    Department of Microbiology, Southern Medical University, Guangzhou, China
    J Biomed Sci 19:19. 2012
    ..However, the molecular mechanism of the interaction between Cryptococcus neoformans and HBMEC, relevant to its brain invasion, is still largely unknown...
  6. pmc CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Virol 86:2416-27. 2012
    ..The data highlight the necessity for temporally and spatially distinct CD4 T cell helper functions in sustaining CD8 T cell activity during CNS infection...
  7. ncbi Central nervous system infections in immunocompromised patients: update on diagnostics and therapy
    Martin Schmidt-Hieber
    Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Leuk Lymphoma 50:24-36. 2009
    ..Additionally, we give an overview on the diagnostics and management of cerebral infections in these patients including evidence evaluation of efficacy of treatment...
  8. pmc Aetiologies of central nervous system infection in Viet Nam: a prospective provincial hospital-based descriptive surveillance study
    Nghia Ho Dang Trung
    Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam
    PLoS ONE 7:e37825. 2012
    ..To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen...
  9. pmc Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections
    Roland Nau
    Department of Geriatrics, Evangelisches Krankenhaus Göttingen Weende, An der Lutter 24, D 37075 Gottingen, Germany
    Clin Microbiol Rev 23:858-83. 2010
    ..Direct injection of drugs, which do not readily penetrate into the CNS, into the ventricular or lumbar CSF is indicated when other effective therapeutic options are unavailable...
  10. ncbi The medical management of central nervous system infections in Uganda and the potential impact of an algorithm-based approach to improve outcomes
    Joel D Trachtenberg
    Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84124, USA
    Int J Infect Dis 11:524-30. 2007
    ..This study examines the medical management of CNS infections in Uganda. We also propose a clinical algorithm to manage CNS infections in an effective, systematic, and resource-efficient manner...
  11. ncbi Are common childhood or adolescent infections risk factors for schizophrenia and other psychotic disorders?
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW
    Med J Aust 190:S17-21. 2009
    ..This pathophysiological path should be investigated more systematically as it may explain a novel "neuroprotective" mode of action for some existing antipsychotic compounds...
  12. ncbi Central nervous system infections in injection drug users
    Allan R Tunkel
    Division of Infectious Diseases, MCP Hahnemann University, 3300 Henry Avenue, Philadelphia, PA 19129, USA
    Infect Dis Clin North Am 16:589-605. 2002
    b>Central nervous system infections in injection drug users are often devastating in terms of excess morbidity and mortality...
  13. ncbi Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections
    Tobias Böttcher
    Department of Neurology, University of Gottingen, Gottingen, Germany
    Neurosci Lett 344:17-20. 2003
    ..The TLR mRNA regulation observed probably represents a combination of specific response to the causative pathogen and non-specific activation of the innate immune system...
  14. ncbi Molecular genetic methods in diagnosis and direct characterization of acute bacterial central nervous system infections
    Muhamed Kheir Taha
    Neisseria Unit and National Reference Center for Meningococci, Institut Pasteur, Paris, France
    APMIS 112:753-70. 2004
    ..In many cases, the molecular assays have decreased the identification time of positive cultures and rescued detection of pathogens in culture-negative clinical samples...
  15. ncbi CNS infection in childhood does not confer risk for later schizophrenia: a case-control study
    Mark Weiser
    Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel
    Schizophr Res 124:231-5. 2010
    ..We sought to contribute to this debate by linking data on persons who had been hospitalized for meningitis as children, with a National Psychiatric Hospitalization Registry...
  16. ncbi Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects
    Christina Dalman
    Department of Psychiatric Epidemiology, EPI Karolinska Institutet, Norrbacka pl 5, 171 76 Stockholm, Sweden
    Am J Psychiatry 165:59-65. 2008
    ..The present study aims to investigate whether there is an increased risk of schizophrenia and other nonaffective psychoses associated with viral or bacterial CNS infections during childhood and, if so, which specific agents are involved...
  17. ncbi In vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against Propionibacterium acnes isolates from central nervous system infections
    Francine Mory
    Laboratoire de Bacteriologie virologie, UMR CNRS 7565, Faculte de Medecine, 54500 Vandoeuvre les Nancy, France
    J Antimicrob Chemother 55:265-8. 2005
    ..To evaluate the antibiotic susceptibilities of Propionibacterium acnes isolates from central nervous system (CNS) infections to agents used in current treatment regimens...
  18. ncbi Improving the diagnosis of central nervous system infections in adults through introduction of a simple lumbar puncture pack
    Benedict Daniel Michael
    Institute of Infection and Global Health, University of Liverpool, West Derby Street, Liverpool L69 7BE, UK
    Emerg Med J 30:402-5. 2013
    ..PCR analysis of the CSF is an important method to identify the pathogen. However, recent studies have demonstrated that many patients have inadequate CSF sample collection and analysis...
  19. ncbi [Importance of urgent cerebrospinal fluid examination for early diagnosis of central nervous system infections]
    Petr Kelbich
    Department of Clinical Biochemistry and Haematology, Regional Hospital Kadan, Czech Republic
    Klin Mikrobiol Infekc Lek 13:9-20. 2007
    ....
  20. ncbi Prevalence of human parechoviruses in central nervous system infections in children: a retrospective study in Shanghai, China
    Huaqing Zhong
    Pediatric Institute, Children s Hospital of Fudan University, Shanghai 201102, China
    J Med Virol 85:320-6. 2013
    ..This study provided data on the molecular epidemiology of HPeV infections in CNS-related diseases in Shanghai, China and suggest that the screening for HPeV by PCR should be included in the routine viral testing of CSF...
  21. pmc A prospective assessment of the accuracy of commercial IgM ELISAs in diagnosis of Japanese encephalitis virus infections in patients with suspected central nervous system infections in Laos
    Catrin E Moore
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
    Am J Trop Med Hyg 87:171-8. 2012
    ..compared with a reference standard (AFRIMS JEV MAC ELISA) in a prospective study of the causes of central nervous system infections in Laos...
  22. ncbi Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection
    Luisa Cervantes-Barragan
    Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    J Immunol 188:3678-85. 2012
    ..Taken together, these results suggest that Tregs preserve CNS immune privilege through selective control of CNS-specific Th cells while keeping protective antiviral immunity fully operative...
  23. pmc Evaluation of MeningoFinder, a novel multiplex ligation-dependent probe amplification assay for simultaneous detection of six virus species causing central nervous system infections
    P F G Wolffs
    Department of Medical Microbiology, Maastricht University Medical Center, The Netherlands
    J Clin Microbiol 47:2620-2. 2009
    ..The assay, termed MeningoFinder, showed an accordance of 97%, concordance of 96%, interlaboratory sensitivity of 90%, and interlaboratory specificity of 94% compared to PCRs...
  24. ncbi Central nervous system infections in HIV-infected patients hospitalized at King Chulalongkorn Memorial Hospital
    Siriporn Kongsiriwattanakul
    Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 94:551-8. 2011
    ..The present study aimed to determine the etiologies, clinical features, treatment, and outcomes of all CNS infections in HIV-infected patients...
  25. ncbi Treatment of central nervous system infections: a neurosurgical perspective
    A P Amar
    Clinical Instructor, Department of Neurological Surgery, University of Southern California, Keck School of Medicine, Los Angeles, USA
    Neuroimaging Clin N Am 10:445-59. 2000
    ..This article surveys the surgical management of intracranial infections with special emphasis on subdural and epidural empyema, brain abscesses, mycotic aneurysms, and neurocysticercosis...
  26. ncbi Central nervous system infections
    David Somand
    Department of Emergency Medicine, University of Michigan, Taubman Center, Ann Arbor, MI 48109 5303, USA
    Emerg Med Clin North Am 27:89-100, ix. 2009
    b>Central nervous system infections have long been recognized as among the most devastating of diseases...
  27. ncbi Blood-brain barrier drug discovery for central nervous system infections
    Ambrose Jong
    Mailstop 57, Childrens Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Curr Drug Targets Infect Disord 5:65-72. 2005
    ..This review focuses on the major BBB drug targeting strategies in the development of therapeutics for CNS infections. A combination of these strategies will ultimately lead to improved treatments...
  28. ncbi Diagnosis-dependent misclassification of infections using administrative data variably affected incidence and mortality estimates in ICU patients
    R Gedeborg
    Department of Surgical Sciences, Section of Anaesthesiology and Intensive Care, Uppsala University Hospital, SE 751 85, Uppsala, Sweden
    J Clin Epidemiol 60:155-62. 2007
    ..To determine the accuracy of hospital discharge diagnoses in identifying severe infections among intensive care unit (ICU) patients, and estimate the impact of misclassification on incidence and 1-year mortality...
  29. ncbi Multiple-year experience in the diagnosis of viral central nervous system infections with a panel of polymerase chain reaction assays for detection of 11 viruses
    Cinnia Huang
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 0509, USA
    Clin Infect Dis 39:630-5. 2004
    ..In other cases, assays exist, but their beneficial use has not been determined. This article summarizes findings from 3485 patients who underwent testing over a 6-year period in our laboratory...
  30. ncbi Neuro-cognitive impairment following acquired central nervous system infections in childhood: a systematic review
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, WC1N 2AP, London, UK
    Brain Res Brain Res Rev 43:57-69. 2003
    ..Higher morbidity for similar mortality in acute bacterial meningitis compared with cerebral malaria in the epidemiological data may suggest future research directions for clinical research to devise more effective interventions...
  31. pmc The role of lumbar puncture in suspected CNS infection--a disappearing skill?
    R Kneen
    The Roald Dahl EEG Unit, Department of Neurology, Royal Liverpool Children s Hospital Alder Hey, Liverpool L12 2AP, UK
    Arch Dis Child 87:181-3. 2002
  32. ncbi Update in the diagnosis and management of central nervous system infections
    Wendy C Ziai
    Division of Neurosciences Critical Care, Departments of Neurology and Anesthesiology Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neurol Clin 26:427-68, viii. 2008
    ....
  33. ncbi Central nervous system infections in the rainforest zone of Nigeria
    C M Nwosu
    School of Midwifery, Ollh Ihiala, Department of Medicine (Neurology/Unit, Nnamdi Azikiwe University Teaching Hospital Nnewi and Department of Surgery, University of Nigeria Teaching Hospital, Enugu, Nigeria
    East Afr Med J 78:97-101. 2001
    OBJECTIVES: To ascertain incidence rates of central nervous system infections and provide information for health care planners...
  34. ncbi Laboratory diagnosis of central nervous system infections
    R B Thomson
    Department of Pathology, Northwestern University Medical School, Evanston, Illinois, USA
    Infect Dis Clin North Am 15:1047-71. 2001
    ..The responsibility for proper use of laboratory testing lies both with the clinician and laboratory technician...
  35. ncbi Cerebrovascular disease in central nervous system infections
    Felicia C Chow
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Semin Neurol 31:286-306. 2011
    ..In this review, we address bacterial, viral, fungal, and parasitic causes of cerebrovascular disease...
  36. ncbi Mycoplasma pneumoniae central nervous system infections
    Florian Daxboeck
    Clinical Institute for Hygiene and Medical Microbiology, Division of Hospital Hygiene, Medical University Vienna, Vienna General Hospital, Vienna, Austria
    Curr Opin Neurol 19:374-8. 2006
    ..This review summarizes and discusses recent findings in the field of M. pneumoniae central nervous system infections in context with previously published findings, with reference to clinical spectrum, pathogenesis, ..
  37. ncbi Central nervous system infections by members of the Pseudallescheria boydii species complex in healthy and immunocompromised hosts: epidemiology, clinical characteristics and outcome
    A Serda Kantarcioglu
    Department of Microbiology and Clinical Microbiology, Cerrahpasa Medical Faculty, Istanbul, Turkey
    Mycoses 51:275-90. 2008
    ..As the therapeutic options were poor, the treatment was difficult in general and the prognosis was poor...
  38. ncbi Stroke and central nervous system infections
    Pratap Sanchetee
    Sanchetee Neurology Research Institute, Jodhpur 342008
    J Indian Med Assoc 107:372-7. 2009
    Stroke is the first cause of disability in adults worldwide. Central nervous system infections as a cause of stroke are not uncommon...
  39. ncbi Drug-induced aseptic meningitis in suspected central nervous system infections
    L Kepa
    Department of Infectious Diseases, Medical University of Silesia, Bytom, Poland
    J Clin Neurosci 12:562-4. 2005
    ..Detailed anamnesis is essential, particularly related to medication use immediately prior to the appearance of symptoms of CNS impairment. In conclusion, the differential diagnosis of CNS infections should include DIAM...
  40. ncbi Continuous electroencephalographic monitoring in critically ill patients with central nervous system infections
    Emmanuel Carrera
    Comprehensive Epilepsy Center, Columbia University Medical Center, 710 W 168th St, Box NI 135, New York, NY 10032, USA
    Arch Neurol 65:1612-8. 2008
    To determine the prevalence, predictors, and clinical significance of electrographic seizures (ESz) and other continuous electroencephalographic monitoring findings in critically ill patients with central nervous system infections.
  41. ncbi Central nervous system infections in cancer patients
    Amy A Pruitt
    Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 10104, USA
    Semin Neurol 24:435-52. 2004
    ..Among several recently recognized syndromes in the latter are infections due to human herpesviruses 6 and 7, West Nile virus, and the immune reconstitution inflammatory syndrome...
  42. ncbi Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections
    R Nau
    Department of Neurology, University of Gottingen, Germany
    Clin Pharmacokinet 35:223-46. 1998
    ..Conclusive evidence of the reduction of neuronal damage by this approach, however, is lacking...
  43. ncbi Childhood central nervous system infections and risk for schizophrenia
    Hannu Koponen
    Department of Psychiatry, University of Oulu, PO Box 5000, 90014 Oulu, Finland
    Eur Arch Psychiatry Clin Neurosci 254:9-13. 2004
    ..Our results suggest that viral CNS infections during childhood may have a role as a risk factor for schizophrenia. Their role may be modest at the population level due to their relative rareness...
  44. ncbi Status epilepticus in central nervous system infections: an experience from a developing country
    Usha Kant Misra
    Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Am J Med 121:618-23. 2008
    There is a paucity of comprehensive study in status epilepticus in central nervous system infections. This observational study evaluated the response to antiepileptic drugs in patients with status epilepticus and central nervous system ..
  45. ncbi The diagnostic usefulness of cerebrospinal fluid lactic acid levels in central nervous system infections
    Burke A Cunha
    Clin Infect Dis 39:1260-1. 2004
  46. pmc Rapid virological diagnosis of central nervous system infections by use of a multiplex reverse transcription-PCR DNA microarray
    Nicolas Leveque
    Clinical and Molecular Virology Unit, University Hospital, and EA 4303 Faculty of Medicine, Reims, France
    J Clin Microbiol 49:3874-9. 2011
    ..4 versus 1.4 days; P = 0.038). In conclusion, this preliminary study showed that this DNA microarray could be a valuable molecular diagnostic tool for single and mixed DNA and RNA virus infections of the CNS...
  47. pmc Clinical evaluation of the function of hypothalamo-pituitary-thyroid axis in children with central nervous system infections
    Fuyong Jiao
    Department of Pediatrics, Shaanxi Provincial People s Hospital, Xi an, China
    Ital J Pediatr 37:11. 2011
    ..It is well known that certain non-thyroidal critical illness may lead to euthyroid sick syndrome(ESS). There are little reports about the change of thyroid hormone in the children's central nervous system (CNS) infections...
  48. ncbi Central nervous system infections
    Zoran Rumboldt
    Department of Radiology, Medical University of South Carolina, 169 Ashley Avenue, Charleston, SC 29425, USA
    Semin Roentgenol 42:62-91. 2007
  49. ncbi Neopterin, biopterin, and nitric oxide concentrations in the cerebrospinal fluid of children with central nervous system infections
    Kohji Azumagawa
    Division of Pediatrics, Yao Tokusyu kai General Hospital, 3 15 38 Kyuhoji, Yao shi, Osaka 581 0072, Japan
    Brain Dev 25:200-2. 2003
    ..Although these findings are preliminary, it may suggest that cerebrospinal fluids nitric oxide would be a useful marker to prospect neurological prognoses in the CNS infections...
  50. pmc Parasitic central nervous system infections in immunocompromised hosts
    Melanie Walker
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Clin Infect Dis 40:1005-15. 2005
    ....
  51. ncbi Central nervous system infections due to Abiotrophia and Granulicatella species: an emerging challenge?
    Elizabeth Cerceo
    University of Medicine and Dentistry of New Jersey, Newark, NJ 07107 3000, USA
    Diagn Microbiol Infect Dis 48:161-5. 2004
    ..Given the significant negative clinical impact of Abiotrophia/Granulicatella infections, elucidation of the emerging epidemiology of CNS infections with these bacteria is warranted...
  52. pmc Cerebrospinal fluid linezolid concentrations in postneurosurgical central nervous system infections
    P Villani
    Antimicrob Agents Chemother 46:936-7. 2002
  53. ncbi Central nervous system infections in the compromised host: a diagnostic approach
    B A Cunha
    State University of New York School of Medicine, Stony Brook, New York, USA
    Infect Dis Clin North Am 15:567-90. 2001
    ..In compromised hosts, differential diagnostic possibilities are more extensive and the likelihood of noninfectious explanations for CNS symptomatology is greater. (ABSTRACT TRUNCATED)..
  54. ncbi Cerebrospinal fluid analysis in the diagnosis and treatment of arterial ischemic stroke
    Emilie M Riou
    Division of Pediatric Neurology, Montreal Children s Hospital McGill University Health Center, Montreal, Quebec, Canada
    Pediatr Neurol 38:1-9. 2008
    ..The analysis of cerebrospinal fluid in arterial ischemic strokes, including apparently idiopathic strokes, may yield essential information on pathophysiology, allowing for optimal therapeutic decisions and prognostic considerations...
  55. ncbi Central nervous system pseudallescheriasis after near-drowning
    Kessarin Panichpisal
    Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA
    Clin Neurol Neurosurg 108:348-52. 2006
    ..Clinical characteristics of central nervous system (CNS) pseudallescheriasis after near-drowning have not been systematically analyzed...
  56. ncbi MR spectroscopy in pediatric neuroradiology
    J V Hunter
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104, USA
    Magn Reson Imaging Clin N Am 9:165-89, ix. 2001
    ..With the introduction of gene therapy and other new interventions, a noninvasive tool such as MR spectroscopy may prove to be invaluable...
  57. ncbi Cerebral infections
    Spyros Karampekios
    Department of Radiology, University of Crete, Stavrakia, 71111, Heraklion, Crete, Greece
    Eur Radiol 15:485-93. 2005
    ....
  58. ncbi [Infectious diseases of brain parenchyma in adults: imaging and differential diagnosis aspects]
    S Hahnel
    Abt Neuroradiologie, Neurologische Klinik, Universitatsklinikum Heidelberg
    Rofo 177:1349-65. 2005
    ..In this review we present the imaging criteria for the most important brain infections in adults and discuss in detail differential diagnostic aspects...
  59. ncbi The changing pattern of HIV neuropathology in the HAART era
    Francoise Gray
    Laboratoire de Neuropathologie, Faculte de Medecine Paris Ile de France Ouest, Garches, France
    J Neuropathol Exp Neurol 62:429-40. 2003
    ..These findings are compared with those reported in other neuropathological studies from different developed countries...
  60. ncbi [Detecting infectious agents in central nervous system inflammation by cerebrospinal fluid analysis]
    H F Petereit
    Klinik und Poliklinik fur Neurologie, Klinikum der Universität zu Köln
    Nervenarzt 77:481-92; quiz 493-4. 2006
    ..The following text gives an overview of appropriate detection methods and their relevance to the most important CNS infections...
  61. ncbi Diffusion and magnetization transfer MRI of brain infarct, infection, and tumor in children
    Margaret H Pui
    Department of Radiology, McMaster University Medical Centre, Hamilton, Ontario, Canada L8N 3Z5
    Clin Imaging 29:162-71. 2005
    ..ADCs increased and MTRs decreased with the duration of infarct and lower tumor grade...
  62. ncbi Discriminatory features of acute transverse myelitis: a retrospective analysis of 45 patients
    Michael Harzheim
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, D 53105, Bonn, Germany
    J Neurol Sci 217:217-23. 2004
    ..Therefore, neurophysiological evidence of PNS involvement may provide additional discriminatory features between ATM-MS and ATM of other etiologies...
  63. ncbi Fetal brain infections
    A James Barkovich
    Neuroradiology, Room L371, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    Childs Nerv Syst 19:501-7. 2003
    ..MRI is also used serially throughout the pregnancy to check for the development of brain abnormalities; medical treatment results in excellent clinical outcome if the brain is normal...
  64. ncbi Beta2-microglobulin concentrations in cerebrospinal fluid correlate with neuroimaging findings in newborns with symptomatic congenital cytomegalovirus infection
    Ana Alarcon
    Department of Pediatrics, Division of Neonatology, Unitat Integrada Hospital Sant Joan de Deu Hospital Clinic, Universitat de Barcelona, 08950 Barcelona, Spain
    Eur J Pediatr 165:636-45. 2006
    ..Cerebrospinal fluid (CSF) findings in congenital CMV infection have seldom been described. Neonates with central nervous system infections present high CSF Beta(2)-microglobulin (beta(2)-m) levels.
  65. ncbi Neuroimaging of animal models of brain disease
    Mark F Lythgoe
    RCS Unit of Biophysics, Institute of Child Health, University College London, UK
    Br Med Bull 65:235-57. 2003
    ..It is important, therefore, to understand the various types of animal model available and choose an appropriate model for the research question...
  66. ncbi Neurologic complications of bone marrow transplantation
    Hendrikus G J Krouwer
    Neuro Oncology Service, Department of Neurology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Neurol Clin 21:319-52. 2003
    ..Prospective studies of HSCT patients in large transplantation centers using clinical registries are needed...
  67. pmc Infectious CNS disease as a differential diagnosis in systemic rheumatic diseases: three case reports and a review of the literature
    K Warnatz
    Department of Rheumatology and Clinical Immunology, Medizinische Klinik, University Hospital, Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Ann Rheum Dis 62:50-7. 2003
    ..The differentiation between primary central nervous system (CNS) involvement and CNS infection may be difficult, leading to delayed diagnosis...
  68. ncbi [A cytological study of cerebrospinal fluid is a key factor in the diagnostic of acute neuroinfections]
    A S Shishov
    Zh Nevrol Psikhiatr Im S S Korsakova 107:65-71. 2007
  69. pmc Early diagnosis of external ventricular drainage infection: results of a prospective study
    W Pfisterer
    Department of Neurosurgery, Donauspital SMZ Ost, Vienna, Austria
    J Neurol Neurosurg Psychiatry 74:929-32. 2003
    ....
  70. ncbi What I have learned about infectious diseases with my sleeves rolled up
    Karen L Roos
    Department of Neurology, Indiana University, Indianapolis, Indiana 46202 5124, USA
    Semin Neurol 22:9-15. 2002
    ....
  71. ncbi Recurrent cerebral fever in the seventeenth and twenty first centuries
    A N Williams
    CDC, Child Health Directorate, Northampton General Hospital, Cliftonville, Northampton NN1 5BD, UK
    Eur J Paediatr Neurol 8:307-12. 2004
    ..The different outcome for a child presenting in the 17th and 21st century encourage grateful reflection on our current privileged position...
  72. ncbi [Differential diagnosis in children having delirium associated with high fever]
    Mitsuru Kashiwagi
    Division of Pediatrics, Hirakata Municipal Hospital, Hirakata, Osaka
    No To Hattatsu 35:310-5. 2003
    ....
  73. ncbi Progressive myelopathy due to meningeal thickening in shunted patients: description of a novel entity and the role of surgery
    Joong Uhn Choi
    Department of Neurosurgery, Yonsei University College of Medicine, 134 Shinchon dong, Sudaemoon ku, Seoul 120 752, South Korea
    Childs Nerv Syst 23:855. 2007
  74. ncbi [Neuroradiologic emergencies in infectious pathology]
    D Ben Salem
    Service de Neuroradiologie et de Radiologie des Urgences, Hopital General, CHU Dijon, 3 rue du Fg raines, 21033 Dijon Cedex, France
    J Neuroradiol 31:301-12. 2004
    ..The CT and MRI features of the more frequent bacterial, viral and parasitic CNS infections will be described...
  75. ncbi The imaging appearances of intracranial CNS infections in adult HIV and AIDS patients
    C E Offiah
    Department of Neuroradiology, Hope Hospital, Salford, Manchester, UK
    Clin Radiol 61:393-401. 2006
    ....
  76. ncbi Role of CT scan in the diagnosis of brain infections
    Sabina Imran
    Department of Radiology, Ayub Teaching Hospital, Abbottabad
    J Ayub Med Coll Abbottabad 14:10-3. 2002
    ..The outcome is usually grave unless promptly diagnosed and properly treated. This study was designed to evaluate the role of CT Scan in the early and correct diagnosis of brain infection...
  77. ncbi PLEDs: clinical correlates
    W Fitzpatrick
    Department of Medicine, Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada
    Can J Neurol Sci 34:443-50. 2007
    ..We reviewed our experience in 96 consecutive patients exhibiting periodic lateralized epileptiform discharges (PLEDs) on EEG...
  78. ncbi The role of nuclear medicine imaging in routine assessment of infectious brain pathology
    I Goethals
    Nucl Med Commun 23:819-26. 2002
  79. ncbi Determination of ceftriaxone in cerebrospinal fluid by ion-pair liquid chromatography
    Marta de Diego Glaría
    University of Concepcion, Pharmacy Department, Pharmacy School, P O Box 237, Concepcion, Chile
    J AOAC Int 88:436-9. 2005
    ..This method was used to quantify ceftriaxone in the cerebrospinal fluid of children with meningitis. The results showed that the method described here is useful for the determination of ceftriaxone in cerebrospinal fluid...
  80. ncbi MRI of neonatal encephalopathy
    P L Khong
    Department of Diagnostic Radiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, People s Republic of China
    Clin Radiol 58:833-44. 2003
    ..perinatal/neonatal stroke, metabolic encephalopathy from inborn errors of metabolism, congenital central nervous system infections and birth trauma...
  81. ncbi Quantitative real time PCR detection of Varicella-zoster virus DNA in cerebrospinal fluid in patients with neurological disease
    Stephan W Aberle
    Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, 1095, Vienna, Austria
    Med Microbiol Immunol 194:7-12. 2005
    ..14). High copy numbers of VZV DNA in CSF were clearly associated with the severity of neurological disease and none of the patients with a VZV viral load below 10(4) copies had a disease course which required intensive care...
  82. ncbi [Use of polymerase chain reaction for the diagnosis of central nervous system infections]
    Yelitza Zambrano
    Laboratorio Genomik, Maracay, Venezuela
    Invest Clin 47:337-47. 2006
    ..Besides this, it is also a very valuable tool for the clinical management of the patients and for the execution of the epidemiological studies...
  83. ncbi Human herpesvirus 6 genome and antigen in acute multiple sclerosis lesions
    Andrew D Goodman
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Infect Dis 187:1365-76. 2003
    ....
  84. ncbi [Diagnosis of epilepsy]
    Jozsef Janszky
    Orszógos Pszichiótriai és Neurológia Intézet, Epilepszia Centrum, Budapest
    Ideggyogy Sz 57:157-63. 2004
    ..The new and quantitative MRI techniques, such as volumetry, T2-relaxometry, MR-spectroscopy, and functional MRI play a growing role in the epilepsy diagnosis...
  85. ncbi Cavernous sinus syndrome: clinical features and differential diagnosis with MR imaging
    Jeong Hyun Lee
    Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul, Korea
    AJR Am J Roentgenol 181:583-90. 2003
  86. ncbi [Cerebral saltwasting syndrome due to infectious diseases of the central nervous system]
    Elisa Cuadrado Godia
    Med Clin (Barc) 128:278-9. 2007
  87. ncbi Nervous system infections in patients with cancer
    Amy A Pruitt
    Department of Neurology, Hospital of the University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19014, USA
    Neurol Clin 21:193-219. 2003
    ....
  88. ncbi Gliomatosis of the brain and spinal cord masquerading as infective lesions
    George Meligonis
    Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa
    Surg Neurol 57:399-404; discussion 404. 2002
    ..The clinico-pathological problems and difficulties in the ante-mortem diagnosis as well as the clinical and pathological similarities to infective lesions are evaluated...
  89. ncbi CNS listeriosis confused with leptomeningeal carcinomatosis in a patient with a malignant insulinoma
    Linda Mileshkin
    Department of Haematology and Medical Oncology, Peter MacCallum Cancer Institute, Melbourne, Australia
    Am J Clin Oncol 25:576-9. 2002
    ..The clinical and radiologic features of this illustrative case are described. Listeriosis is an important treatable differential diagnosis in patients with malignancy presenting with neurologic signs...
  90. ncbi The clinical relevance of EEG interpretation
    E Niedermeyer
    The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland, USA
    Clin Electroencephalogr 34:93-8. 2003
    ..quot; Continuing neglect of functional/dysfunctional orientation can seriously endanger the entire field of Neurology...
  91. ncbi Unusual presentation of central nervous system cryptococcal infection in an immunocompetent patient
    Gaurav Saigal
    Department of Radiology, Jackson Memorial Hospital, University of Miami, Miami, FL 33136, USA
    AJNR Am J Neuroradiol 26:2522-6. 2005
    ..We report a case of an extremely unusual MR appearance of central nervous system cryptococcosis in a 49-year-old immunocompetent man...
  92. ncbi Granulomatous diseases of the central nervous system
    Antonio Jose da Rocha
    Department of Neuroradiology, Santa Casa de Misericordia de Sao Paulo, Brazil
    Top Magn Reson Imaging 16:155-87. 2005
    ..Taking these parameters into account we will discuss the several patterns of image found in parasitic, bacterial, and fungal granulomatous infections...
  93. ncbi A multicenter prospective cohort study of the Strata valve for the management of hydrocephalus in pediatric patients
    John R W Kestle
    Division of Pediatric Neurosurgery, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    J Neurosurg 102:141-5. 2005
    ..To evaluate these claims, the authors conducted a prospective multicenter cohort study of children who underwent placement of Strata valves...
  94. ncbi An unusual sequelae of an infected persistent dermal sinus tract
    R Shane Tubbs
    Department of Pediatric Neurosurgery, Children s Hospital, Birmingham, AL 35233, USA
    Childs Nerv Syst 23:569-71. 2007
    ..Subsequent lower extremity pain resulted in imaging studies that revealed a spinal mass with extension into the posterior mediastinum. At operation, the child was found to have an infected dermal sinus tract...
  95. ncbi Transient acute obstructive hydrocephalus of unknown origin in a 13-month-old infant
    Antonios F Vakis
    Department of Neurosurgery, University of Crete, Medical School, Heraklion University Hospital, Heraklion, Crete, Hellas
    Eur J Paediatr Neurol 10:197-201. 2006
    ..The dexamethasone treatment was discontinued 3 days later. Follow up CT and MRI scans were normal. We discuss the case and the possible causes of transient hydrocephalus in children...
  96. ncbi Multiple ring enhancing brain lesions on computed tomography: an Indian perspective
    Ravindra Kumar Garg
    Department of Neurology, King George s Medical University, Lucknow 226003, India
    J Neurol Sci 266:92-6. 2008
    ..Several published case reports suggest that multiple enhancing lesions of the brain can occur with a wide variety of infective and non-infective etiologies...
  97. ncbi Otogenic intracranial complications. a 7-year retrospective review
    Maky A Hafidh
    The Department of Otolaryngology, Head and Neck Surgery, Beaumont University Hospital, Dublin, Ireland
    Am J Otolaryngol 27:390-5. 2006
    ..We also reviewed the timing of both otologic and neurosurgical treatments...
  98. ncbi Viral diseases of the central nervous system
    Claudia Leite
    University of Sao Paulo, Sao Paulo, Brazil
    Top Magn Reson Imaging 16:189-212. 2005
    ..All of these groups of diseases are discussed in this article, with an emphasis on their imaging presentation, using magnetic resonance imaging...
  99. ncbi The need for vigilance
    Bernard Touati
    Pract Proced Aesthet Dent 19:76. 2007
  100. ncbi Diffusion-weighted MR imaging: pediatric clinical applications
    Pallavi Sagar
    Division of Pediatric Radiology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimaging Clin N Am 16:45-74, viii. 2006
    ....
  101. ncbi Spinal infections
    E Turgut Tali
    Department of Radiology, Division of Neuroradiology, Gazi University School of Medicine, Besevler, Ankara, 06510, Turkey
    Eur Radiol 15:599-607. 2005
    ....

Research Grants62

  1. Novel Therapeutics for Neurotropic Alphaviruses
    David J Miller; Fiscal Year: 2013
    ..equine encephalitis viruses are transmitted by mosquitoes, cause serious and potentially fatal central nervous system infections in humans, and are considered NIAID Category B Priority Pathogens due to their potential misuse as ..
  2. Pathobiology of C. neoformans in the Central Nervous System
    John R Perfect; Fiscal Year: 2012
    Cryptococcus neoformans is one of the most common life-threatening central nervous system infections in humans and despite present treatments, morbidity and mortality still remain high...
  3. Intra- and Inter-Neuronal Viral Trafficking
    Glenn F Rall; Fiscal Year: 2012
    ..and inter-neuronal transport, and to establish how this mode of spread is associated with chronic central nervous system infections. These broad objectives will be accomplished through completion of two Specific Aims...
  4. New Therapies for Pathogenic Free-Living Amoebae
    Dennis E Kyle; Fiscal Year: 2013
    ..The major goals of this project are to discover lead compounds for development as drugs to treat the central nervous system infections with pathogenic FLA...
  5. Discovery and evaluation of fungicidal anti-cryptococcal molecules
    Damian J Krysan; Fiscal Year: 2012
    ..provided by applicant): Cryptococcus neoformans is a fungal pathogen that causes pulmonary and central nervous system infections in immunocompromised and, less commonly, immunocompetent patients...
  6. Improving neurologic outcome measurement for interventional research in Ibadan
    Steffen Sammet; Fiscal Year: 2013
    ..public health threats including cerebrovascular disease, neurodegenerative disorders, brain trauma, central nervous system infections, neurodevelopmental disorders, drug addiction and psychiatric disorders...
  7. Aseptic Meningoencephalitis Syndrome (AMS) In Adults
    Rodrigo Hasbun; Fiscal Year: 2010
    ..The candidate is committed to a career in clinical investigation of patients with central nervous system infections. To develop his capacity to engage in cross-disciplinary clinical research, his plan includes ..
  8. MECHANISM BASED DRUG SELECTION AND DESIGN FOR T GONDII
    Keith Joiner; Fiscal Year: 1999
    Toxoplasma gondii is the leading cause of focal central nervous system infections in patients with the acquired immunodeficiency syndrome (AIDS). The limited repertoire of therapeutic agents for T...
  9. REGULATION OF INTESTINAL FUNCTION BY ADULT TAPEWORMS
    JOHN OAKS; Fiscal Year: 2000
    ..and frequently it is women, as the family food preparer, who suffer a disproportionate number of central nervous system infections. Because of the insidiousness of the adult infection and potential impact of this stage on the ..
  10. PATHOGENESIS OF PERSISTENT VIRAL INJURY TO THE CNS
    Francisco Gonzalez Scarano; Fiscal Year: 2002
    ..around the common theme of the role of viral receptors and cellular entry in the pathogenesis of central nervous system infections. The program has 7 major components: 4 projects and 3 cores, including an administrative core. Dr...
  11. PROTEIN TARGETING TO AND THROUGH THE T GONDII PVM
    Keith Joiner; Fiscal Year: 2000
    DESCRIPTION (adapted from the ABSTRACT): Toxoplasma gondii is the leading cause of local central nervous system infections in patients with AIDS. T...
  12. Phospholipid metabolism and traffic in T. gondii
    Keith Joiner; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Toxoplasma gondii is an important cause of focal central nervous system infections in patients with HIV, lethal infections in heart transplant patients, and devastating congenital ..
  13. GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2002
    ..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
  14. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
  15. Genome-wide screening of E. coli for bacteremia
    Kwang Kim; Fiscal Year: 2007
    ..coli bacteremia should help in development of preventive measures such as vaccines against E. coli bacteremia. [unreadable] [unreadable] [unreadable]..
  16. E. coli invasion of brain endothelial cells
    Kwang Kim; Fiscal Year: 2008
    ..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
  17. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
  18. E. COLI BINDING TO BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2003
    ....
  19. Retrovial Infections of the Nervous System in Peru
    JOSEPH RAYMOND ZUNT; Fiscal Year: 2010
    ..building on research collaborations and investigations initiated during the R21 grant entitled "Central Nervous System Infections in Peru";and to continue development of neurologist investigators in academic and research ..
  20. Central Nervous System Infections in Peru
    Joseph Zunt; Fiscal Year: 2004
    ..The second year will be used to complete and analyze these pilot studies and prepare the R01 application. ..
  21. NEUROLOGIC/IMMUNOLOGIC MANIFESTATION OF HTLV-I INFECTION
    Joseph Zunt; Fiscal Year: 2004
    ....
  22. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  23. Invasion of C. neoformans into brain endothelial cells
    Ambrose Jong; Fiscal Year: 2008
    ..The information derived from the studies is expected to be helpful in the development of novel strategies to prevent cryptococcal meningitis and its associated morbidity. ..
  24. Immune Responses During Measles Virus Infection
    Diane Griffin; Fiscal Year: 2007
    ..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
  25. Transcutaneous and oral-transcutaneous cholera immunization with TcpA and Peru15
    Edward Ryan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2008
    ..abstract_text> ..
  27. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  28. 2007 Viruses & Cells Gordon Conference
    Diane Griffin; Fiscal Year: 2007
    ..abstract_text> ..
  29. Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact
    Diane Griffin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  31. Staff Hand Hygiene and Nosocomial Infections in Neonates
    Elaine Larson; Fiscal Year: 2003
    ....
  32. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2004
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  33. Mucosal Immunity to Antigens Expressed by V.cholerae
    Edward Ryan; Fiscal Year: 2006
    ..difficile toxin A is injected into ligated ileal loops of vaccinated and control animals. ..
  34. Protection of Mice From Lethal Alphavirus Encephalitis
    David N Irani; Fiscal Year: 2010
    ....
  35. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  36. ASSAY TO DETECT ACUTE ACTIVE LYME DISEASE
    Steven Schutzer; Fiscal Year: 2005
    ..It can also detect infection early than free antibody assays. Therefore this assay can fulfill a great need in Lyme disease diagnosis and has high market potential. ..
  37. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  38. Viral Host Interactions in SIV Cardiac Dysfunction
    Joseph Mankowski; Fiscal Year: 2008
    ..These studies will set the stage for performing interventive studies in SIV-infected macaques using approaches to target specific MMPs to prevent cardiac dysfunction. [unreadable] [unreadable] [unreadable]..
  39. Mechanisms of HIV-Induced PNS Disease: The SIV Macaque Model
    Joseph Mankowski; Fiscal Year: 2009
    ..The goal of these comprehensive, integrated studies of HIV sensory neuropathy in our novel SIV primate model is to advance the understanding of HIV-SN pathogenesis to foster new therapeutic approaches. ..
  40. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    ..abstract_text> ..
  41. Gender differences in immune responses in MS
    Richard Ransohoff; Fiscal Year: 2009
    ....
  42. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..We will test the hypothesis that unregulated virus growth increases expression of TIMP-1, preventing MMP mediated leukocyte migration through the CNS parenchyma. ..
  43. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2004
    ..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
  44. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  45. RISK OF PORCINE PICORNAVIRUS IN XENOTRANSPLATATION
    M Njenga; Fiscal Year: 2003
    ..The long-term goal is to transplant pig organs/tissues containing persistent porcine virus into primates in order to determine the risk of disease. ..
  46. Novel Methods to Access Brain Function in HIV-1
    Christina Marra; Fiscal Year: 2003
    ..abstract_text> ..
  47. Assay to detect early neurologic Lyme disease
    Steven Schutzer; Fiscal Year: 2003
    ..BbIC Ab and Ag will be identified. Focus will be towards on specific and in vivo expressed Bb Ags. Results will be statistically analyzed. Phase 2 will be designed for broadscale usage and refinement. ..
  48. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  49. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  50. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  51. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
    ..abstract_text> ..
  52. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  53. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..The data acquired could provide new insights and therapeutic intervention strategies for monocyte BBB trafficking during progressive HIV-1 infection in brain tissue. ..
  54. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2007
    ..We believe that information gained under these specific aims will elucidate mechanisms whereby SHP-1 controls virus infections in oligodendrocytes and perhaps other cells of the CNS. ..
  55. Genetics of Neuropathogenic SIV Infection
    Francis Novembre; Fiscal Year: 2007
    ..Finally, we will investigate the evolution of the ability of these viruses to induce the production of neurotoxins in CNS derived cells. ..
  56. ESCHERICHIA COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Sheng He Huang; Fiscal Year: 2007
    ..To further characterize the role of IbeABP in E. coil K1 invasion of human BMEC. (3). To determine how E. coil K1 invasion gene expression is regulated by the IbeR and environmental signals (glucose and oxygen tension). ..
  57. Detection of Virulent Burkholderia mallei
    Steven Schutzer; Fiscal Year: 2006
    ..In Phase 2 we will also develop the immuno-based assays. ..
  58. Rapid and Simple CSF Tests for Neurosyphillis Diagnosis
    Christina Marra; Fiscal Year: 2006
    ..The results of this study will be used to design field trials in the areas of greatest need. ..
  59. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
    ....
  60. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  61. MEASLES VACCINES--IMMUNE RESPONSES AND ATYPICAL MEASLES
    Diane Griffin; Fiscal Year: 2001
    ....
  62. NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIA
    Shailendra Joshi; Fiscal Year: 2005
    ..abstract_text> ..