brain abscess

Summary

Summary: A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)

Top Publications

  1. ncbi Brain abscess in 142 patients: factors influencing outcome and mortality
    Jen Ho Tseng
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan
    Surg Neurol 65:557-62; discussion 562. 2006
  2. doi A review of brain abscess surgical treatment--78 years: aspiration versus excision
    Thiloka Erandathi Ratnaike
    Department of Neurosurgery, Newcastle University, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    World Neurosurg 76:431-6. 2011
  3. ncbi Strategies for the management of bacterial brain abscess
    Cheng Hsien Lu
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
    J Clin Neurosci 13:979-85. 2006
  4. ncbi Brain abscess in infants and children: a retrospective study of 107 patients in northeast Thailand
    Narong Auvichayapat
    Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    J Med Assoc Thai 90:1601-7. 2007
  5. doi Central nervous system infections: meningitis and brain abscess
    Hitoshi Honda
    Division of Infectious Diseases, Washington University of School of Medicine, 660 South Euclid Avenue, Campus Box, 8051 Saint Louis, MO 63110, USA
    Infect Dis Clin North Am 23:609-23. 2009
  6. ncbi Brain abscess: clinical experience and analysis of prognostic factors
    Furen Xiao
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Surg Neurol 63:442-9; discussion 449-50. 2005
  7. doi Distinction between pyogenic brain abscess and necrotic brain tumour using 3-tesla MR spectroscopy, diffusion and perfusion imaging
    I C Chiang
    Department of Radiology, Kaohsiung Municipal Hsiao Kang Hospital, 482 San Ming Road, Hsiao Kang District, Kaohsiung, Taiwan
    Br J Radiol 82:813-20. 2009
  8. doi Intracranial abscesses: changes in epidemiology and management over five decades in Merseyside
    R Sharma
    Department of Medical Microbiology, University Hospital Aintree, Lower Lane, Liverpool, L9 7AL, UK
    Infection 37:39-43. 2009
  9. ncbi Listeria monocytogenes brain abscess: two cases and review of the literature
    Samornrod Limmahakhun
    Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 44:468-78. 2013
  10. ncbi Brain abscess and cystic brain tumor: discrimination with dynamic susceptibility contrast perfusion-weighted MRI
    Cuneyt Erdogan
    Uludag University School of Medicine, Department of Radiology, Bursa, Turkey
    J Comput Assist Tomogr 29:663-7. 2005

Detail Information

Publications268 found, 100 shown here

  1. ncbi Brain abscess in 142 patients: factors influencing outcome and mortality
    Jen Ho Tseng
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan
    Surg Neurol 65:557-62; discussion 562. 2006
    With the introduction of CT, stereotactic techniques, and broad-spectrum antibiotics, the outcome for brain abscess has dramatically improved...
  2. doi A review of brain abscess surgical treatment--78 years: aspiration versus excision
    Thiloka Erandathi Ratnaike
    Department of Neurosurgery, Newcastle University, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    World Neurosurg 76:431-6. 2011
    The literature regarding surgical treatment of brain abscess was reviewed from 1990 to (and including) 2008 to supplement a previous literature review from 1930 to 1990.
  3. ncbi Strategies for the management of bacterial brain abscess
    Cheng Hsien Lu
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
    J Clin Neurosci 13:979-85. 2006
    We reviewed the medical and surgical management of brain abscess and compared the results of different methods of treatment...
  4. ncbi Brain abscess in infants and children: a retrospective study of 107 patients in northeast Thailand
    Narong Auvichayapat
    Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    J Med Assoc Thai 90:1601-7. 2007
    To review the clinical manifestation, predisposing factor location of abscess, causative organism, treatment, and outcome of brain abscess.
  5. doi Central nervous system infections: meningitis and brain abscess
    Hitoshi Honda
    Division of Infectious Diseases, Washington University of School of Medicine, 660 South Euclid Avenue, Campus Box, 8051 Saint Louis, MO 63110, USA
    Infect Dis Clin North Am 23:609-23. 2009
    Despite advances in antimicrobial and antiviral therapy, meningitis and brain abscess are infections that result in significant morbidity and mortality...
  6. ncbi Brain abscess: clinical experience and analysis of prognostic factors
    Furen Xiao
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Surg Neurol 63:442-9; discussion 449-50. 2005
    Over the past 2 decades, the diagnosis and treatment of brain abscess have been facilitated by a number of technological advancements, which have resulted in a significant improvement of outcome...
  7. doi Distinction between pyogenic brain abscess and necrotic brain tumour using 3-tesla MR spectroscopy, diffusion and perfusion imaging
    I C Chiang
    Department of Radiology, Kaohsiung Municipal Hsiao Kang Hospital, 482 San Ming Road, Hsiao Kang District, Kaohsiung, Taiwan
    Br J Radiol 82:813-20. 2009
    ..Although the conventional MRI characteristics of cerebral abscesses and necrotic tumours may sometimes be similar, diffusion, perfusion-weighted and spectroscopic MRI enables distinction between the two...
  8. doi Intracranial abscesses: changes in epidemiology and management over five decades in Merseyside
    R Sharma
    Department of Medical Microbiology, University Hospital Aintree, Lower Lane, Liverpool, L9 7AL, UK
    Infection 37:39-43. 2009
    ....
  9. ncbi Listeria monocytogenes brain abscess: two cases and review of the literature
    Samornrod Limmahakhun
    Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 44:468-78. 2013
    ..Listerial brain abscesses are rare. We report here two brain abscess cases caused by L. monocytogenes in patients receiving immunosuppressive agents...
  10. ncbi Brain abscess and cystic brain tumor: discrimination with dynamic susceptibility contrast perfusion-weighted MRI
    Cuneyt Erdogan
    Uludag University School of Medicine, Department of Radiology, Bursa, Turkey
    J Comput Assist Tomogr 29:663-7. 2005
    ..003). Perfusion MRI may allow the differentiation of pyogenic brain abscess from cystic brain tumors, making it a strong additional imaging modality in the early diagnosis of these two ..
  11. pmc Clostridium sordellii brain abscess diagnosed by 16S rRNA gene sequencing
    F Valour
    Service des Maladies Infectieuses et Tropicales, Hopital de la Croix Rousse, 103 Grande Rue de la Croix Rousse, 69004 Lyon, France
    J Clin Microbiol 48:3443-4. 2010
    ..We describe the first case to our knowledge of a Clostridium sordellii-associated brain abscess, diagnosed by 16S rRNA gene sequencing, expanding the microbiological spectrum of brain abscesses, with ..
  12. ncbi Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia
    C L Shovlin
    NHLI Cardiovascular Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Thorax 63:259-66. 2008
    ..Brain abscesses and ischaemic strokes complicate pulmonary arteriovenous malformations (PAVMs). At risk individuals are poorly recognised. Stroke/abscess risk factors have not been defined...
  13. ncbi [A case of amebic brain abscess]
    Akitsugu Morishita
    Department of Neurosurgery, Toyooka Hospital, 1094 Tobera, Toyooka shi, Hyogo 668 8501, Japan
    No Shinkei Geka 35:919-25. 2007
    Amebic brain abscess is a rare and usually fatal complication of Entamoeba histolytica infections. We successfully treated a patient with this infection accompanied by brain, liver and pulmonary abscesses...
  14. doi Brain abscess due to Panton-Valentine leukocidin-positive Staphylococcus aureus
    A Ramos
    Department of Internal Medicine Infectious Diseases Unit, Spanish Network for Research in Infectious Disease, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, San Martin de Porres no 4, Madrid, Spain
    Infection 37:365-7. 2009
    ..A 34-year-old man admitted for right parietal brain abscess and thickened dura mater in close proximity to a lytic bone lesion is presented...
  15. ncbi Piperacillin/tazobactam in treatment of brain abscess
    Ameli Javad
    Department of Neurology, Baqyatallah University of Medical Science, Tehran, Iran
    Scand J Infect Dis 38:224-6. 2006
    ..Successful management of a brain abscess usually requires a combination of antibiotics and surgical drainage for both diagnostic and therapeutic ..
  16. ncbi Brain abscess in which Porphyromonas gingivalis was detected in cerebrospinal fluid
    Yutaka Iida
    Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Br J Oral Maxillofac Surg 42:180. 2004
    In this paper, we report one case of severe brain abscess in which Porphyromonas gingivalis was detected in the spinal fluid.
  17. pmc Legionella micdadei brain abscess
    Marthe Charles
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    J Clin Microbiol 51:701-4. 2013
    We describe an immunocompromised patient who developed a large frontal brain abscess caused by Legionella micdadei. This is, to our knowledge, a rare case of culture-proven Legionella central nervous system infection.
  18. ncbi Culture-negative brain abscess with Streptococcus intermedius infection with diagnosis established by direct nucleotide sequence analysis of the 16s ribosomal RNA gene
    Naoko Saito
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
    Intern Med 51:211-6. 2012
    ..The patient exhibited complete remission. Thus, 16S rRNA gene analysis was highly useful not only for pathogen identification with negative culture results but also for the appropriate selection of antibiotics...
  19. ncbi Brain abscess secondary to a dental infection in an 11-year-old child: case report
    Christine E Hibberd
    Faculty of Dentistry, University of Toronto, Toronto, Ontario
    J Can Dent Assoc 78:c49. 2012
    A primary molar dental abscess was implicated as the cause of a brain abscess in an 11-year-old boy. This case report describes the neurological signs and symptoms, and acute management of a brain abscess in a child...
  20. ncbi Complications of chronic suppurative otitis media: a left otogenic brain abscess and a right mastoid fistula
    Yok Kuan Chew
    Department of Otorhinolaryngology, Hospital Sultanah Aminah, 81000 Johor Bahru, Malaysia
    Ear Nose Throat J 91:428, 430. 2012
    Otogenic brain abscess and postauricular fistula are complications of chronic suppurative otitis media...
  21. doi The importance of a proper aetiological diagnosis in the management of patients with invasive mycoses: a case report of a brain abscess by Scedosporium apiospermum
    Giuseppina Caggiano
    Department of Biomedical Science and Human Oncology Hygiene section, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy
    Mycopathologia 172:317-22. 2011
    ..The authors describe a fatal case of a S. apiospermum brain abscess in a 58-year-old female...
  22. ncbi Paradoxical reaction during treatment of tuberculous brain abscess in a patient with AIDS
    Jose E Vidal
    Rev Inst Med Trop Sao Paulo 45:177-8. 2003
  23. doi A rare presentation of ventriculitis and brain abscess caused by Fusobacterium nucleatum
    Anneke Kai
    Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QW, UK
    J Med Microbiol 57:668-71. 2008
    ..We report what we believe to be the first case of ventriculitis and brain abscess due to Fusobacterium nucleatum infection in a man with no significant predisposing factors...
  24. ncbi Clinical characteristics of fusobacterial brain abscess
    Mei Jen Hsieh
    Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Jpn J Infect Dis 60:40-4. 2007
    ..bacterial brain abscesses (BBA) at our hospital over a period of 20 years and identified seven fusobacterial brain abscess patients...
  25. ncbi Linezolid in the treatment of brain abscess due to Peptostreptococcus
    Federica Salin
    Department of Infectious and Tropical Diseases, University Hospital, Padova, Italy
    Scand J Infect Dis 38:203-5. 2006
    ..We describe a case of brain abscess secondary to anaerobic infection with Peptostreptococcus, which was successfully treated with parenteral and ..
  26. doi Brain abscess caused by Gemella morbillorum: case report and review of the literature
    Silky Chotai
    Korea University Guro Hospital, Department of Neurosurgery, Seoul, Democratic People s Republic of Korea
    Turk Neurosurg 22:374-7. 2012
    ..To the best of our knowledge only eight cases of Gemella morbillorum brain abscess have been reported in the literature...
  27. doi Apparent diffusion coefficient with higher b-value correlates better with viable cell count quantified from the cavity of brain abscess
    V Tomar
    Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    AJNR Am J Neuroradiol 32:2120-5. 2011
    ..VCD in the abscess cavity correlates with ADC values. The purpose of this study was to investigate which b-value-derived ADC correlates better with VCD...
  28. pmc Pyogenic brain abscess, a 15 year survey
    Jannik Helweg-Larsen
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    BMC Infect Dis 12:332. 2012
    b>Brain abscess is a potentially fatal disease. This study assesses clinical aspects of brain abscess in a large hospital cohort.
  29. doi Feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging to evaluate brain abscess lesion: in vivo canine model
    Tong In Oh
    Department of Biomedical Engineering, Kyung Hee University, Yongin, Korea
    J Magn Reson Imaging 38:189-97. 2013
    ..electrical impedance tomography (MREIT) conductivity imaging in terms of its capability to provide new contrast information of abscess lesion and characterize time-course variations before and after the induction of brain abscess.
  30. ncbi An unusual case of brain abscess by Gemella morbillorum
    Maria Carla Liberto
    Department of Medical Sciences, Institute of Microbiology, University of Catanzaro, Catanzaro, Italy
    Jpn J Infect Dis 59:126-8. 2006
    A case of deep brain abscess by Gemella morbillorum is described...
  31. doi Imaging of cerebritis, encephalitis, and brain abscess
    Tanya J Rath
    Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Neuroimaging Clin N Am 22:585-607. 2012
    Imaging plays an important role in the diagnosis and treatment of brain abscess, pyogenic infection, and encephalitis. The role of CT and MRI in the diagnosis and management of pyogenic brain abscess and its complications is reviewed...
  32. ncbi Fungal brain abscess in transplant recipients: epidemiologic, microbiologic, and clinical features
    John W Baddley
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, 35294 0006, USA
    Clin Transplant 16:419-24. 2002
    Fungal brain abscess is an unusual but serious complication associated with solid organ and hematopoietic stem cell transplantation...
  33. doi The study of etiologic and demographic characteristics of intracranial brain abscess: a consecutive case series study from Pakistan
    Nabeel Manzar
    Dow University of Health Sciences, Karachi, Pakistan
    World Neurosurg 76:195-200; discussion 79-83. 2011
    ....
  34. ncbi Persistent immune activation associated with a mouse model of Staphylococcus aureus-induced experimental brain abscess
    Aaron C Baldwin
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Slot 510 4301 W Markham Street Little Rock, AR 72205, USA
    J Neuroimmunol 151:24-32. 2004
    We have established a mouse experimental brain abscess model using Staphylococcus aureus where lesion sites are greatly exaggerated compared to the localized area of initial infection, reminiscent of an overactive immune response...
  35. ncbi The intermediate filament GFAP is important for the control of experimental murine Staphylococcus aureus-induced brain abscess and Toxoplasma encephalitis
    Werner Stenzel
    Abteilung für Neuropathologie, Universitat zu Koln, Koln, Germany
    J Neuropathol Exp Neurol 63:631-40. 2004
    ..protein glial fibrillary acidic protein (GFAP) in CNS infections was studied in Staphylococcus aureus-induced brain abscess. Compared to wild type (WT) mice, GFAP(0/0) mice developed larger and more poorly demarcated inflammatory ..
  36. ncbi Microbiology and epidemiology of brain abscess and subdural empyema in a medical center: a 10-year experience
    Tsung Pei Tsou
    Department of Pediatrics, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, Taiwan
    J Microbiol Immunol Infect 42:405-12. 2009
    b>Brain abscess and subdural empyema are the 2 most common forms of intracranial pyogenic infections. Predisposing factors and etiological agents may change with time. This study examined the epidemiological features of these conditions.
  37. ncbi Brain abscess--diagnosis and management
    Ali Akbar Bhand
    Department of Neurosurgery, Chandka Medical College, VIP Road, Larkana, Sindh, Pakistan
    J Coll Physicians Surg Pak 14:407-10. 2004
    To evaluate the clinical presentation, diagnosis, sources of infection, surgical management outcome and microorganisms involved in the brain abscess in our locality.
  38. ncbi Treatment of a brain abscess caused by Scedosporium apiospermum and Phaeoacremonium parasiticum in a renal transplant recipient
    Noppadol Larbcharoensub
    Division of Anatomical Pathology, Faculty of Medicine Ramathibodi Hospital Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 44:484-9. 2013
    ..Voriconazole may represent a new therapeutic option for these simultaneous infections in the brain...
  39. doi Brain abscess: an overview
    Dattatraya Muzumdar
    Department of Neurosurgery, Seth Gordhandas Sunderdas Medical College and King Edward VII Memorial Hospital, Parel, Mumbai, India
    Int J Surg 9:136-44. 2011
    ..the advent of newer antibiotics and surgical strategies, the overall outcome and quality of life issues in brain abscess patients still remain a continuous challenge for the neurosurgical community...
  40. doi Brain abscess: a cogent clarifier of the confused concept of immunity
    Manu Kothari
    Department of Anatomy, King Edward Memorial Hospital, Parel, Mumbai, India
    Neurosurg Focus 24:E16. 2008
    ..Brain abscesses tend to stand apart from the host tissue so as to allow easy aspiration and/or ablation. A brain abscess is a dire neurosurgical emergency. The saving grace is that a few quick steps yield excellent results.
  41. ncbi [Brain abscess caused by Nocardia sp in immunosuppressed patient]
    C H Barata
    Disciplina de Doencas Infecciosas e Parasitarias, Faculdade de Medicina do Triangulo Mineiro, Av Getúlio Guaritá s n, 38025 000 Uberaba, MG, Brazil
    Rev Soc Bras Med Trop 33:609-12. 2000
    ..purpura (Evans Syndrome), treated with immunosuppressive therapy (prednisone and azathioprine) developed brain abscess unresponsive to antimicrobial therapy, in spite of its 23 days duration...
  42. ncbi Diffusion-weighted MR imaging in the preoperative assessment of brain abscesses
    Eric C Leuthardt
    Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri, USA
    Surg Neurol 58:395-402; discussion 402. 2002
    ..Diffusion-weighted MR imaging (DWI) has recently shown promise in differentiating ring-enhancing lesions such as brain abscess and malignant neoplasm...
  43. ncbi Brain abscess: clinical aspects of 100 patients
    Eva Tonon
    Infectious Diseases Division, Ca Foncello Regional Hospital, Piazza Ospedale, 31100 Treviso, Italy
    Int J Infect Dis 10:103-9. 2006
    To verify if, in the last two decades, there have been any changes in epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of patients with brain abscess.
  44. doi The experiences of non-operative treatment in patients with bacterial brain abscess
    S Y Hsiao
    Departments of Emergency Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Clin Microbiol Infect 17:615-20. 2011
    Although treatment of brain abscess requires a combination of antimicrobials and surgical intervention for the infected foci, nonsurgical, empirical treatment is possible and efficient in selected groups of patients...
  45. ncbi Brain abscess in children
    Mehnaz Atiq
    Department of Paediatrics, The Aga Khan University Hospital, Karachi, Pakistan
    Indian J Pediatr 73:401-4. 2006
    b>Brain abscess is a serious life-threatening complication of several diseases...
  46. ncbi Treatment of brain abscess caused by Listeria monocytogenes in a patient with allergy to penicillin and trimethoprim-sulfamethoxazole
    Otto Leiti
    Clin Infect Dis 40:907-8. 2005
  47. ncbi Community-acquired brain abscess in Taiwan: etiology and probable source of infection
    Yuen Hua Ni
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:231-5. 2004
    b>Brain abscess is a life-threatening infection caused by spread from infected parameningeal or remote foci...
  48. pmc TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses
    Jessica R Nichols
    Department of Pediatrics, Arkansas Children s Hospital, Little Rock, AR 72205, USA
    J Immunol 182:7119-30. 2009
    ..role in recognizing Staphylococcus aureus, a common etiologic agent of CNS parenchymal infections, such as brain abscess. We previously reported that brain abscesses of TLR2 knockout (KO) mice exhibited elevated IL-17 levels, ..
  49. doi Solitary Nocardia farcinica brain abscess in an immunocompetent adult mimicking metastatic brain tumor: rapid diagnosis by pyrosequencing and successful treatment
    Christopher A Iannotti
    Brain Tumor Institute and the Department of Neurological Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Surg Neurol 72:74-9; discussion 79. 2009
    Nocardia brain abscess carries a higher morbidity and mortality rate than other bacterial cerebral abscesses, with reported mortality rates of 55% and 20% in immunocompromised and immunocompetent patients, respectively...
  50. ncbi A case of delayed brain abscess due to a retained intracranial wooden foreign body: a case report and review of the last 20 years
    Y Nishio
    Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Acta Neurochir (Wien) 146:847-50. 2004
    ..She visited our department with fever and headache, and a brain abscess and an intracranial foreign body were found on computed tomography (CT) and magnetic resonance image (MRI) 7 ..
  51. ncbi Diffusion-weighted MRI features of brain abscess and cystic or necrotic brain tumors: comparison with conventional MRI
    Shih Chin Chang
    Department of Radiology, Veterans General Hospital Kaohsiung, National Yang Ming University, National Sun Yat Sen University, 386 Ta Chung First Road, Kaohsiung, Taiwan, ROC
    Clin Imaging 26:227-36. 2002
    ....
  52. doi Taming an old enemy: a profile of intracranial suppuration
    Narendra Nathoo
    Department of Neurosurgery, Wentworth Hospital, University of KwaZulu Natal, Durban, KwaZulu Natal, South Africa
    World Neurosurg 77:484-90. 2012
    Intracranial suppurative disorders (ICSDs; brain abscess, empyema, and purulent ventriculitis), have been a scourge through the ages and attempts at curative surgery, as for cranial trauma, are considered to be one of the first true ..
  53. doi Cystic metastasis versus brain abscess: role of MR imaging in accurate diagnosis and implications on treatment
    Prakash Shetty
    Department of Surgical Oncology, Neurosurgery Services, Tata Memorial Centre, Parel, Mumbai, India
    J Cancer Res Ther 6:356-8. 2010
    ..We discuss this case and review the literature regarding the role of newer MRI sequences and the ramifications on patient treatment...
  54. pmc Brain abscess caused by Phaeoacremonium parasiticum in an immunocompromised patient
    Candice J McNeil
    Stanford University School of Medicine, Division of Infectious Diseases and Geographic Medicine, 300 Pasteur Drive, Grant S 101, Stanford, CA 94305 5107, USA
    J Clin Microbiol 49:1171-4. 2011
    ..We report the first documented case of central nervous system involvement with brain abscess formation in a patient with chronic granulomatous disease and review the literature on Phaeoacremonium ..
  55. pmc Roles of Toll-like receptor 2 (TLR2) and superantigens on adaptive immune responses during CNS staphylococcal infection
    Debbie Vidlak
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Brain Behav Immun 25:905-14. 2011
    ..aureus recognition. However, the interplay between TLR2, SAG, and adaptive immunity during brain abscess formation has not yet been investigated and could reveal novel insights into host-pathogen interactions for ..
  56. ncbi Are dental infections a cause of brain abscess? Case report and review of the literature
    M A Corson
    Newcastle upon Tyne NHS Trust, Dental Hospital and School, Richardson Road, Newcastle upon Tyne, NE2 4AZ, UK
    Oral Dis 7:61-5. 2001
    ..In order to confirm the role of odontogenic infection in the pathogenesis of brain abscess, modern sampling techniques should be used to precisely identify the isolates...
  57. ncbi Not just a 'simple stroke'
    Wendy Russell
    MBChB Ed, MRCP StR4 in General Internal Medicine Acute Monklands Hospital Monkscourt Avenue, Airdrie, ML6 0JS
    Acute Med 10:35-7. 2011
    ..He was transferred for urgent craniotomy and evacuation of a Streptococcus milleri abscess. Following several weeks of neurosurgical care and antibiotics he made a near full recovery...
  58. pmc First report of a brain abscess caused by Nocardia veterana
    J E Arends
    Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Heidelberglaan 100, P O Box 85500, F 02 126, 3508 GA Utrecht, The Netherlands
    J Clin Microbiol 49:4364-5. 2011
    ..This is the first presentation of a case of brain abscess attributable to an N. veterana infection in a patient with type 2 diabetes...
  59. ncbi Haemophilus aphrophilus brain abscess: a case report
    Pao Tsuan Kao
    Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 35:184-6. 2002
    ..Craniotomy was performed, abscess was drained, and H. aphrophilus was isolated. Following the surgical procedure and further antibiotic treatment, the patient recovered completely...
  60. doi Management outcome of NPC-related and non-NPC-related brain abscess in Hong Kong
    Mandy Ho Man Tam
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Clin Neurol Neurosurg 114:560-3. 2012
    1) To review the patient profile, management outcome and prognostic factors of brain abscess; (2) To compare the neurological outcome of nasopharyngeal carcinoma (NPC)-related brain abscess with non-NPC related brain abscess.
  61. pmc Brevibacterium casei as a cause of brain abscess in an immunocompetent patient
    V Anil Kumar
    Department of Microbiology, Amrita Institute of Medical Sciences, Ponekkara, Kochi, Kerala 682041, India
    J Clin Microbiol 49:4374-6. 2011
    ..We report the first case of B. casei brain abscess in an immunocompetent patient successfully treated by surgery and antimicrobial therapy.
  62. doi Streptococcus sanguinis brain abscess as complication of subclinical endocarditis: emphasizing the importance of prompt diagnosis
    Hayah Kassis
    Department of Internal Medicine, Northeastern Ohio Universities College of Medicine and Pharmacy, Rootstown, OH, USA
    South Med J 103:559-62. 2010
    A 19-year-old male patient was diagnosed with S. sanguinis brain abscess of unknown etiopathology as a complication of subclinical endocarditis. While viridans streptococci are implicated in dental seeding to the heart, S...
  63. doi Central nervous system infections in the intensive care unit
    Benjamin M Greenberg
    Johns Hopkins School of Medicine, Johns Hopkins Encephalitis Center, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Semin Neurol 28:682-9. 2008
    ..When certain infections are suspected, such as bacterial meningitis or viral encephalitis, empiric therapy should be initiated immediately. Outcomes for these conditions are linked to how quickly appropriate therapies are initiated...
  64. ncbi Improved diagnosis of a temporal lobe abscess in a post-irradiated nasopharyngeal carcinoma patient using diffusion-weighted magnetic resonance imaging
    W C Wong
    Department of Radiology, Queen Mary Hospital, Hong Kong
    Clin Radiol 57:1040-3. 2002
  65. doi Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy
    Joseph S Doyle
    Infectious Diseases Unit, The Alfred Hospital, Melbourne, Victoria, Australia
    J Neurosurg 114:458-62. 2011
    ..This case describes successful treatment of a Balamuthia mandrillaris brain abscess using prolonged antimicrobial agents with complete excision...
  66. doi Optimization of bacterial diagnosis yield after needle aspiration in immunocompetent adults with brain abscesses
    Victoire de Lastours
    Internal Medicine Department, Beaujon Hospital, Assistance Publique Hopitaux de Paris, Clichy, France
    Neurosurgery 63:362-7; discussion 367-8. 2008
    ..Our purpose was to evaluate the efficacy of a strategy aimed at obtaining a microbiological diagnosis in immunocompetent patients presenting with suspected BAs...
  67. ncbi Fusobacterial brain abscess: a review of five cases and an analysis of possible pathogenesis
    Xiang Y Han
    Department of Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosurg 99:693-700. 2003
    The cases of five patients with fusobacterial brain abscess are presented. The authors discuss their attempt to determine the pathogenesis.
  68. pmc Encephalitozoon cuniculi genotype I as a causative agent of brain abscess in an immunocompetent patient
    Oleg Ditrich
    Biology Centre of the Academy of Sciences of the Czech Republic, vvi, Institute of Parasitology, Branisovska 31, 37005 Ceske Budejovice, Czech Republic
    J Clin Microbiol 49:2769-71. 2011
    A brain abscess caused by Encephalitozoon cuniculi genotype I together with Streptococcus intermedius occurred in a patient without major immunocompromise and with diabetes. The distinguishing clinical signs were hemiparesis and epilepsy...
  69. pmc Evaluation of capsular and acapsular strains of S. aureus in an experimental brain abscess model
    Nilufer Esen
    Department of Neurology, Holtom Garrett Program in Neuroimmunology, University of Michigan Medical School, Ann Arbor, MI 48109, United States
    J Neuroimmunol 218:83-93. 2010
    ..In the present study, we aimed to compare potential changes in brain abscess pathogenesis induced by two different strains of S...
  70. ncbi Bacterial brain abscesses: an evaluation of 96 cases
    Tayfun Hakan
    Neurosurgery Department, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    J Infect 52:359-66. 2006
    Although the decline of the morbidity and mortality in recent years, brain abscess is still one of the most important problems in Neurosurgery.
  71. ncbi Previously-treated nasopharyngeal carcinoma with cystic lesions in the temporal lobe
    T Rajendra
    Department of Neurosurgery, National Neuroscience Institute SGH Campus, Outram Road, Singapore 169608
    Singapore Med J 45:590-3. 2004
    ..The three cases presented consist of radiation necrosis, pyogenic abscess, and a case with both infection with tumour recurrence. The methodology of both clinical and radiological diagnosis are presented...
  72. doi Never go to sleep on undrained pus: a retrospective review of surgery for intraparenchymal cerebral abscess
    S J Smith
    Department of Neurosurgery, Queen s Medical Centre, Nottingham University Hospitals, Nottingham, United Kingdom
    Br J Neurosurg 23:412-7. 2009
    ..Delay had an adverse affect, so operation should be as expeditious as possible whenever the differential diagnosis includes abscess, diagnosis of which may be aided by advanced magnetic resonance imaging techniques...
  73. pmc A k2A-positive Klebsiella pneumoniae causes liver and brain abscess in a Saint Kitt's man
    Melissa S Doud
    Department of Biological Sciences, College of Arts and Sciences, Florida International University, Miami, Florida 33199, USA
    Int J Med Sci 6:301-4. 2009
    ..The K2 serotype has also been strongly associated with hypervirulence. We report the isolation of non-magA, K2 K. pneumoniae strain from a liver abscess of a Saint Kitt's man who survived the invasive syndrome...
  74. ncbi Prodromal signs and clinical factors influencing outcome in patients with intraventricular rupture of purulent brain abscess
    M Takeshita
    Department of Neurosurgery, Neurological Institute, Tokyo Women s Medical University, Japan
    Neurosurgery 48:310-6; discussion 316-7. 2001
    To elucidate prodromal signs and clinical factors influencing the prognosis in patients with intraventricular rupture of brain abscess (IVROBA) to prevent and manage this catastrophic condition.
  75. doi Meropenem monotherapy is as effective as and safer than imipenem to treat brain abscesses
    G Martin-Canal
    Department of Infectious Diseases, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, Celestino Villamil s n, 33006 Oviedo, Spain
    Int J Antimicrob Agents 35:301-4. 2010
    ..5-2g/day) [combined standard chemotherapy (CSC)] for the treatment of brain abscess was compared...
  76. ncbi Diagnosis and management of brain abscess and subdural empyema
    Gary L Bernardini
    Departments of Neurology and Neurosurgery, Albany Medical Center, 47 New Scotland Avenue, MC 70, Albany, NY 12208, USA
    Curr Neurol Neurosci Rep 4:448-56. 2004
    Advances in the diagnosis and treatment of brain abscess and subdural empyema with neuroimaging techniques such as computerized tomography, magnetic resonance imaging, magnetic resonance spectroscopy, the availability of new ..
  77. ncbi [A complicated case of Nocardia brain abscess for differential diagnosis]
    Daisuke Wakui
    Department of Neurosurgery, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki shi, Kanagawa 216 8511, Japan
    No Shinkei Geka 36:1011-6. 2008
    Nocardia brain abscess is rare and has uncertain clinical features. Radiological differential diagnosis based on the metabolic feature of Nocardia is discussed.
  78. pmc Brain abscess due to Gemella haemolysans
    Mi Ra Lee
    Division of Infectious Diseases, Gil Medical Center, Gachon Medical School, Incheon, Korea
    J Clin Microbiol 42:2338-40. 2004
    We present a case of brain abscess due to Gemella haemolysans and Bacteroides species in a 60-year-old-immunocompetent man who underwent dental procedures...
  79. doi Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature
    Janette C Rahamat-Langendoen
    Department of Microbiology, Izore Centre for Infectious Diseases Friesland, Leeuwarden, The Netherlands
    J Clin Periodontol 38:702-6. 2011
    ..We report a patient with multiple brain abscesses due to infection with A. actinomycetemcomitans and review the English language literature related to this subject...
  80. doi Management of brain abscess in children
    Miguel Gelabert-Gonzalez
    Department of Surgery, Service of Neurosurgery, Clinic Hospital of Santiago, University of Santiago de Compostela, Spain
    J Paediatr Child Health 44:731-5. 2008
    ..The objective of this paper is to report the treatment of 28 children with the diagnosis of brain abscess.
  81. ncbi [Brain abscess in a third-level hospital: epidemiology and prognostic factors related to mortality]
    M Gutiérrez-Cuadra
    Unidad de Enfermedades Infecciosas, Hospital Universitario Marques de Valdecilla, Universidad de Cantabria, Avda Valdecilla, S N, 39008 Santander, Cantabria, Spain
    Rev Esp Quimioter 22:201-6. 2009
    To document the epidemiology, causes, treatment and prognostic factors associated with mortality of patients with brain abscess in a tertiary medical center.
  82. ncbi Undiagnosed amebic brain abscess
    Parnpen Viriyavejakul
    Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 40:1183-7. 2009
    We report a case of amebic brain abscess due to Entamoeba histolytica. The patient was a 31-year-old man who presented with amebic liver abscess. His clinical course deteriorated in spite of proper drainage and treatment...
  83. doi Tuberculous temporal brain abscess mimicking otogenic pyogenic abscess
    D Muzumdar
    Department of Neurosurgery, Seth Gordhandas Sunderdas Medical College and King Edward VII Memorial Hospital, Mumbai, India
    Pediatr Neurosurg 45:220-4. 2009
    Tuberculous brain abscess is a rare manifestation of central nervous system tuberculosis. We report the case of a tuberculous temporal lobe abscess in a 14-year-old female child that mimicked an otogenic pyogenic brain abscess...
  84. ncbi Middle and posterior fossa aspergilloma
    Jacob P Alapatt
    Department of Neurosurgery, Medical College Hospital, Thrissur, Kerala 680001, India
    Surg Neurol 66:75-8; discussion 78-9. 2006
    ..Because of its rarity in immunocompetent patients and the difficulty in preoperative diagnosis, we have illustrated this case and its presentation and management...
  85. doi Successful treatment of sellar aspergillus abscess
    Wenke Liu
    Department of Neurosurgery, West China Hospital, Sichuan University, Wuhou District, Chengdu 610041, China
    J Clin Neurosci 17:1587-9. 2010
    ..Early and correct diagnosis via surgery can improve the prognosis. A combination of surgical resection and antifungal therapy has a good outcome. The importance of early treatment for sellar aspergillus abscesses is emphasised...
  86. ncbi Cerebellar aspergillosis: case report and literature review
    Ersin Erdogan
    Department of Neurosurgery, Gulhane Military Medical School, Ankara, Turkey
    Neurosurgery 50:874-6; discussion 876-7. 2002
    ..An unusual, but not unique, case of cerebellar aspergillosis associated with autologous peripheral blood stem cell transplantation for breast cancer is presented...
  87. ncbi Brain abscess due to Listeria monocytogenes: first case report in Thailand
    Pornpit Treebupachatsakul
    Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 89:1516-20. 2006
    b>Brain abscess with bacteremia caused by Listeria monocytogenes in a young woman with immune thrombocytopenic purpura was reported. The clinical features included fever, headache, and left-side weakness...
  88. ncbi Pyogenic brain abscess: findings from in vivo 1.5-T and 11.7-T in vitro proton MR spectroscopy
    Ping H Lai
    Department of Radiology, Veterans General Hospital Kaohsiung, National Yang Ming University, 386 Ta Chung First Road, Taiwan 813, Republic of China
    AJNR Am J Neuroradiol 26:279-88. 2005
    ..We compared the findings of in vivo with those of in vitro MR spectroscopy and categorized the MR spectral patterns with respect to the causative organisms and abscess size...
  89. doi Preoperative antifungal therapy may improve survival in patients with Aspergillus brain abscess
    Mohammad Wasay
    Department of Neurology, Medicine, Infectious Diseases and Community Health, Aga Khan University, Karachi 74800, Pakistan
    Clin Neurol Neurosurg 111:565-7. 2009
    The objective of this study was to determine if the preoperative use of antifungal therapy positively influences clinical outcome in patients with Aspergillus brain abscess.
  90. ncbi Brain abscess due to Entamoeba histolytica
    C Sundaram
    Department of Pathology, Nizam s Institute of Medical Sciences, Hyderabad
    J Assoc Physicians India 52:251-2. 2004
    ..A patient of cerebral amoebiasis due to Entamoeba histolytica with no evidence of disease elsewhere is described. He made a complete recovery after surgical excision of the abscess along with metronidazole therapy...
  91. ncbi Brain abscess complicating cerebral infarct
    Yichayaou Beloosesky
    Department of Geriatrics, Rabin Medical Center, Golda Campus, Sackler School of Medicine, Tel Aviv University, Petach Tikva 49372, Israel
    Age Ageing 31:477-80. 2002
    ..We report a case of a 68-year-old man who suffered ischemic strokes in the left middle cerebral artery territory and three months later, following urosepsis, developed a cerebral abscess in the infarcted area...
  92. doi Staphylococcus massiliensis sp. nov., isolated from a human brain abscess
    Mouhamad Al Masalma
    Laboratoire de Bacteriologie virologie, Hopital de la Timone, URMITE CNRS IRD UMR 6236, IFR48, 264 rue Saint Pierre, 13385 Marseille, Cedex 05, France
    Int J Syst Evol Microbiol 60:1066-72. 2010
    ..coagulase-negative, non-motile, non-fermentative and novobiocin-susceptible cocci were isolated from a human brain abscess sample (strain 5402776(T)). This novel strain was analysed by a polyphasic taxonomic approach...
  93. pmc Kocuria varians infection associated with brain abscess: a case report
    Cheng Yu Tsai
    Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    BMC Infect Dis 10:102. 2010
    ..previously was classified into Micrococcus. Only two species, K. rosea and K. kristinae are reported to be associated as pathogenic and found with catheter-related bacteremia and acute cholecystitis...
  94. ncbi Brain abscess caused by Cladophialophora Bantiana in an immunocompetent host: need for a novel cost-effective antifungal agent
    S A Borkar
    Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi 110 029, India
    Indian J Med Microbiol 26:271-4. 2008
    ..Radiological evaluation was suggestive of brain abscess. He underwent gross total excision of the cerebral abscess...
  95. doi Propionibacterium acnes brain abscess appearing 10 years after neurosurgery
    Sarah M Kranick
    Hospital of University of Pennsylvania, Department of Neurology, 3 W Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Neurol 66:793-5. 2009
    ..To describe a case of Propionibacterium acnes infection arising 10 years after neurosurgery and to review the literature regarding similar cases and their treatment...
  96. ncbi Delayed postoperative intracerebral abscess caused by Proprionibacterium acnes: case report and review of the literature
    S A Barazi
    Department of Neurosurgery, Charing Cross Hospital, London, UK
    Br J Neurosurg 17:336-9. 2003
    ..We propose the inclusion of cerebral abscess by P. acnes in the differential diagnosis of lesions that mimic tumour recurrences, after clean craniotomies...
  97. doi Alternaria infectoria brain abscess in a child with chronic granulomatous disease
    E Hipolito
    Hospital Pediátrico de Coimbra, Portugal
    Eur J Clin Microbiol Infect Dis 28:377-80. 2009
    In the present report, we describe the first case of a phaeohyphomycotic brain abscess in a 5-year-old boy with chronic granulomatous disease (CGD) admitted to hospital with seizures...
  98. ncbi Brain abscess due to Arcanobacterium haemolyticum after dental extraction
    Jair Vargas
    Clin Infect Dis 42:1810-1. 2006
  99. ncbi A rare but fatal case of granulomatous amebic encephalitis with brain abscess: the first case reported from Turkey
    Feyzi Birol Sarica
    Baskent University, School of Medicine, Neurosurgery Department, Ankara, Turkey
    Turk Neurosurg 19:256-9. 2009
    ..This paper presents a case of GAE with abscess formation in a 75-year-old male patient...
  100. ncbi Vertically acquired neonatal citrobacter brain abscess - case report and review of the literature
    Deepak Agrawal
    Department of Neurosurgery, Neurosciences Center, All India Institute of Medical Sciences, New Delhi 110029, India
    J Clin Neurosci 12:188-90. 2005
    ..An aggressive surgical approach combined with intravenous antibiotics (including imipenems, to which the organism is very sensitive) for a minimum of 4 weeks appears to improve the outcome of infection with this virulent organism...
  101. pmc Brain abscess caused by Nocardia cyriacigeorgica in a patient with human immunodeficiency virus infection
    G Barnaud
    Service de Microbiologie, Hopital Louis Mourier, Colombes, France
    J Clin Microbiol 43:4895-7. 2005
    Nocardia cyriacigeorgica is a recently characterized species within the genus of Nocardia. We report a brain abscess, following a primary pulmonary colonization, due to this species in a human immunodeficiency virus-infected patient...

Research Grants17

  1. CYTOKINE INFLAMMATORY MEDIATORS AND MUCIN REGULATION IN MIDDLE EAR EPITHELIUM
    Joseph E Kerschner; Fiscal Year: 2013
    ..in young children [4,7-8], and is associated with life-threatening complications such as meningitis and brain abscess formation [9- 10]...
  2. Role of T cells during central nervous system (CNS) bacterial infection
    MONICA MARIE MARIANI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Brain abscess formation is consequent of pyogenic bacterial infection, and can elicit inflammation, edema, neuronal toxicity, and often long-term health problems such as seizures...
  3. Effects of Neuroinflammation on Gap Junction Communication in Glia
    TAMMY L KIELIAN; Fiscal Year: 2010
    ..junction communication (GJC) is parenchymal infection with pyogenic bacteria leading to the establishment of brain abscess. Recent studies have revealed that several proinflammatory mediators detected in developing brain abscesses ..
  4. The Pathogenesis of Brain Abscess
    TAMMY L KIELIAN; Fiscal Year: 2013
    The host anti-bacterial immune response that ensues during brain abscess development not only neutralizes pathogens but also contributes to the destruction of surrounding normal brain parenchyma...
  5. Receptors Involved in Microglial Responses to S. aureus
    TAMMY L KIELIAN; Fiscal Year: 2010
    ..aureus-induced brain abscess model leads to the heightened expression of IL-17, a cytokine that has been implicated in anti-bacterial ..
  6. VASCULAR PERMEABILITY AND BRAIN EDEMA IN BRAIN ABSCESS
    Warren Lo; Fiscal Year: 1992
    ..The project will employ a rat model of a staphylococcal brain abscess to test the hypothesis that bacterial products increase the permeability of the blood-brain barrier, and ..
  7. Microglial Cell Activation by Thrombin in Stroke
    Jonathan Weinstein; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  8. ADHERENCE BLOCKING VACCINE FOR AMEBIASIS
    William Petri; Fiscal Year: 2003
    ..In Project 3, the applicants will attempt to develop a novel adjuvant, based on the ricin B subunit to improve the immunogenicity of proteins in plants. ..
  9. Toll-Like Receptor 3 Activation in Astrocytes
    GREGORY KONAT; Fiscal Year: 2006
    ..Moreover, because TLR3 can also be activated by RNA released from damaged cells, the outcomes of this study will also be applicable to neurodegenerative conditions of non-viral etiology. [unreadable] [unreadable]..
  10. Hippocampus/Pituitary Ratio: an AD Brain Injury Marker?
    Thomas Beresford; Fiscal Year: 2005
    ..abstract_text> ..
  11. Rapid Diagnostics for Category B Enteropathogens
    William Petri; Fiscal Year: 2007
    ..Successful completion of these studies will yield high throughput diagnostic tests that target multiple enteropathogens simultaneously in a single sample. ..
  12. GENE EXPRESSION IN ENTAMOEBA HISTOLYTICA
    William Petri; Fiscal Year: 2008
    ..Successful completion of these studies will provide insight into transcription regulation of virulence factors by the novel mechanism of direct calcium control of an EF-hand containing transcription factor. ..
  13. SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATION
    Barnett Nathan; Fiscal Year: 2003
    ..SP and NO modulate their effects in CNS inflammation via these cells. Hypothesis 4: The ultimate site for the effects of SP and NO may be the mitochondrial respiratory chain enzymes of these phagocytic cells. ..
  14. Hindbrain Herniation in Sheep Model of Myelomeningocele
    Cornelia von Koch; Fiscal Year: 2002
    ..Furthermore, we will characterize in lambs gross pathological and axonal pathfinding anomalies usually seen in the human disease. ..
  15. Genetic Virulence Markers in Respiratory Syncytial Virus
    RICHARD MARTINELLO; Fiscal Year: 2006
    ..A committee consisting of established basic scientists, clinical researchers and hospital epidemiology mentors has been established to provide scientific guidance and training oversight. ..
  16. Prevention of Catheter-Associated Blood Stream Infections
    David Warren; Fiscal Year: 2007
    ..I will build on the experience outlined in this proposal to establish myself an independent investigator in healthcare epidemiology, studying nosocomial infections and developing interventions to prevent them. [unreadable] [unreadable]..