streptococcal infections

Summary

Summary: Infections with bacteria of the genus STREPTOCOCCUS.

Top Publications

  1. ncbi The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
  2. ncbi Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010
    Jennifer R Verani
    National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, N E, MS C 23, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-36. 2010
  3. ncbi Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis
    Karen M Edmond
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 379:547-56. 2012
  4. ncbi Genetic basis for the beta-haemolytic/cytolytic activity of group B Streptococcus
    C A Pritzlaff
    Division of Pediatric Infectious Diseases, University of California, San Diego, 9500 Gilman Drive 0672, La Jolla, CA 92093, USA
    Mol Microbiol 39:236-47. 2001
  5. ncbi Molecular insight into invasive group A streptococcal disease
    Jason N Cole
    Department of Pediatrics, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, 92093 0687, USA
    Nat Rev Microbiol 9:724-36. 2011
  6. ncbi Group B streptococcal infections in elderly adults
    Morven S Edwards
    Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 41:839-47. 2005
  7. ncbi Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990-2007
    Tami H Skoff
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:85-92. 2009
  8. pmc A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotyping
    Eve Haguenoer
    Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno fœtal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, Tours, France
    BMC Microbiol 11:171. 2011
  9. pmc Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 4:e6072. 2009
  10. pmc SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2
    Ming Li
    Department of Microbiology, Third Military Medical University, Chongqing, China
    PLoS ONE 3:e2080. 2008

Detail Information

Publications307 found, 100 shown here

  1. ncbi The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
    ..On a global scale, GAS is an important cause of morbidity and mortality. These data emphasise the need to reinforce current control strategies, develop new primary prevention strategies, and collect better data from developing countries...
  2. ncbi Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010
    Jennifer R Verani
    National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, N E, MS C 23, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-36. 2010
    ..In the absence of a licensed GBS vaccine, universal screening and intrapartum antibiotic prophylaxis continue to be the cornerstones of early-onset GBS disease prevention...
  3. ncbi Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis
    Karen M Edmond
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 379:547-56. 2012
    ..However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates...
  4. ncbi Genetic basis for the beta-haemolytic/cytolytic activity of group B Streptococcus
    C A Pritzlaff
    Division of Pediatric Infectious Diseases, University of California, San Diego, 9500 Gilman Drive 0672, La Jolla, CA 92093, USA
    Mol Microbiol 39:236-47. 2001
    ..coli. We conclude that cylE probably represents the structural gene for the GBS haemolysin/cytolysin, a novel bacterial toxin...
  5. ncbi Molecular insight into invasive group A streptococcal disease
    Jason N Cole
    Department of Pediatrics, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, 92093 0687, USA
    Nat Rev Microbiol 9:724-36. 2011
    ..Understanding the molecular basis and mechanism of initiation for streptococcal invasive disease may expedite the discovery of novel therapeutic targets for the treatment and control of severe invasive GAS diseases...
  6. ncbi Group B streptococcal infections in elderly adults
    Morven S Edwards
    Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 41:839-47. 2005
    ..The safety and immunogenicity of GBS serotype V-tetanus toxoid conjugate vaccine in healthy elderly persons suggest the potential for vaccination as an approach to prevention of invasive GBS infections in elderly persons...
  7. ncbi Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990-2007
    Tami H Skoff
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:85-92. 2009
    ..We used population-based surveillance to examine trends in adult GBS disease during the period 1990-2007 and to describe the epidemiology of adult GBS disease to guide prevention efforts...
  8. pmc A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotyping
    Eve Haguenoer
    Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno fœtal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, Tours, France
    BMC Microbiol 11:171. 2011
    ..We describe here a genotyping method based on multiple locus variable number of tandem repeat (VNTR) analysis (MLVA) applied to a population of S. agalactiae strains of various origins characterized by MLST and serotyping...
  9. pmc Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 4:e6072. 2009
    ..suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in China with high levels of mortality. The mechanisms of S. suis pathogenesis in humans and pigs are poorly understood...
  10. pmc SalK/SalR, a two-component signal transduction system, is essential for full virulence of highly invasive Streptococcus suis serotype 2
    Ming Li
    Department of Microbiology, Third Military Medical University, Chongqing, China
    PLoS ONE 3:e2080. 2008
    ..However, the molecular pathogenesis of this new emerging pathogen is still poorly understood...
  11. pmc Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2
    Jiaqi Tang
    Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China
    PLoS Med 3:e151. 2006
    ....
  12. ncbi Streptococcus suis: a new emerging or an old neglected zoonotic pathogen?
    Marcelo Gottschalk
    Streptococcus suis Research Laboratory and International Reference Laboratory for S suis Serotyping, Departement de Pathologie et Microbiologie, Universite de Montreal, CP 5000, St Hyacinthe, Quebec, Canada
    Future Microbiol 5:371-91. 2010
    ..In this article we critically review the present knowledge on S. suis infection in humans, we discuss the hypotheses that may explain the 2005 outbreak and the repercussion of such an episode on the scientific community...
  13. ncbi Survey of the incidence and aetiology of mastitis on dairy farms in England and Wales
    A J Bradley
    School of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 160:253-7. 2007
    ..Staphylococcus aureus and coagulase-positive staphylococci together accounted for 10 per cent of the samples with high somatic cell counts; 39 per cent produced no bacterial growth...
  14. pmc Rise and persistence of global M1T1 clone of Streptococcus pyogenes
    Ramy K Aziz
    Department of Microbiologyand Immunology, Cairo University, Cairo, Egypt
    Emerg Infect Dis 14:1511-7. 2008
    The resurgence of severe invasive group A streptococcal infections in the 1980s is a typical example of the reemergence of an infectious disease...
  15. ncbi Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America
    Alan L Bisno
    Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
    Clin Infect Dis 35:113-25. 2002
  16. pmc Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response
    Paul Sumby
    Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:1679-84. 2005
    ..We conclude that extracellular DNase activity made by GAS contributes to disease progression, thereby resolving a long-standing question in bacterial pathogenesis research...
  17. ncbi Streptococcus suis infections in humans: the Chinese experience and the situation in North America
    Marcelo Gottschalk
    Centre de Recherche en Infectiologie Porcine CRIP, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, St Hyacinthe, Quebec, J2S 2M2, Canada
    Anim Health Res Rev 8:29-45. 2007
    ..Here, we review the epidemiological, clinical and immunopathological features of S. suis infection in humans...
  18. pmc Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity
    Sheng Mei Jiang
    Division of Infectious Diseases, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Bacteriol 190:1956-65. 2008
    ..Such variation is likely to play an important role in strain-specific adaptation of GBS to particular host environments and pathogenic potential in susceptible hosts...
  19. pmc GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2
    Ming Li
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Mol Microbiol 79:1670-83. 2011
    ..This is the first demonstration of horizontal transfer of a Gram-positive PAI mediated by a GI-type T4SS. We propose that these genetic events are important in the emergence, pathogenesis and persistence of epidemic S. suis 2 strains...
  20. pmc Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense
    George Y Liu
    Department of Pediatrics, The Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:14491-6. 2004
    ..Together, these data suggest a mechanism by which the linked cylE-encoded phenotypes, betaH/C (sword) and carotenoid (shield), act in partnership to thwart the immune phagocytic defenses...
  21. ncbi M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage
    Heiko Herwald
    Department of Cell and Molecular Biology, Lund University, Tornavagen 10, S 221 84 Lund, Sweden
    Cell 116:367-79. 2004
    ..In addition, M protein/fibrinogen complexes were identified in tissue biopsies from a patient with necrotizing fasciitis and STSS, further underlining the pathogenic significance of such complexes in severe streptococcal infections.
  22. ncbi Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
    Hongmin Sun
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Science 305:1283-6. 2004
    ..In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens...
  23. pmc Quorum sensing and biofilm formation in Streptococcal infections
    Dennis G Cvitkovitch
    Room 449A, Dental Research Institute, University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada
    J Clin Invest 112:1626-32. 2003
    ..These quorum-sensing systems are primarily made of small soluble signal peptides that are detected by neighboring cells via a histidine kinase/response regulator pair...
  24. ncbi Superantigen gene profile diversity among clinical group A streptococcal isolates
    Linda Maripuu
    Biomedical Laboratory Science, Department of Clinical Microbiology, Umea University, Umea, Sweden
    FEMS Immunol Med Microbiol 54:236-44. 2008
    ..The 22 smeZ alleles were generally linked to the emm-genotype. The results of the investigation show that superantigen gene profiling is useful for tracking spread of clones in the community...
  25. ncbi Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America
    Stanford T Shulman
    Department of Pediatrics, Division of Infectious Diseases, Ann and Robert H Lurie Children s Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 55:1279-82. 2012
    ..Penicillin or amoxicillin remain the treatments of choice, and recommendations are made for the penicillin-allergic patient, which now include clindamycin...
  26. ncbi Getting under the skin: the immunopathogenesis of Streptococcus pyogenes deep tissue infections
    Linda Johansson
    Karolinska Institutet, Center for Infectious Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Infect Dis 51:58-65. 2010
    ..We review here the host-pathogen interactions in the tissue milieu and discuss the use of intravenous immunoglobulin as potential adjunctive therapy in these life-threatening infections...
  27. pmc M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment
    Laura E Crotty Alexander
    Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Mol Med (Berl) 88:371-81. 2010
    ....
  28. ncbi The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004
    Rosalyn E O'Loughlin
    Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 45:853-62. 2007
    ..We report the current epidemiologic characteristics of invasive GAS infections and estimate the potential impact of a multivalent GAS vaccine...
  29. pmc Interactions between endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates and human endothelial cells
    Tanja Vollmer
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Bad Oeynhausen, Germany
    BMC Microbiol 10:78. 2010
    ..gallolyticus subsp. gallolyticus endothelial infection. In addition, the strains were analyzed for the presence of the three virulence factors gtf, pilB, and fimB by PCR...
  30. pmc Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China
    Ying Ma
    CAS Key Laboratory of Pathogenic Microbiology and Immunology CASPMI, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing 100101, The People s Republic of China
    Philos Trans R Soc Lond B Biol Sci 364:2725-37. 2009
    ..All of these pathogens occur in Southeast Asia, including China, with severe consequences; therefore, we discuss the issues in this article by addressing the situation of the zoonotic threat in China...
  31. pmc Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates
    Tadayoshi Ikebe
    Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS Pathog 6:e1000832. 2010
    ..7%). The results of the present study suggest that mutations in the negative regulators csrS/csrR and rgg of S. pyogenes are crucial factors in the pathogenesis of STSS, as they lead to the overproduction of multiple virulence factors...
  32. ncbi Thermosensitive suicide vectors for gene replacement in Streptococcus suis
    D Takamatsu
    Molecular Bacteriology Section, National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki, 305 0856, Japan
    Plasmid 46:140-8. 2001
    ..suis and other streptococci of veterinary importance by means of allelic exchange of the genes of interest via homologous recombination...
  33. pmc Serotype IX, a Proposed New Streptococcus agalactiae Serotype
    Hans Christian Slotved
    Neisseria and Streptococcus Reference Laboratory, Department for Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    J Clin Microbiol 45:2929-36. 2007
    ..They all share the same, unique partial cps sequence. These results indicate that these eight isolates represent a new S. agalactiae serotype, which we propose should be designated serotype IX...
  34. pmc Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection
    Fiona C McKay
    Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Infect Immun 72:364-70. 2004
    ..Despite considerable amino acid sequence variation within the A1 repeat region of PAM where the plasminogen-binding domain maps, the critical lysine residue was conserved...
  35. ncbi Streptococcus suis: an emerging human pathogen
    Heiman F L Wertheim
    Oxford University Clinical Research Unit, National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam
    Clin Infect Dis 48:617-25. 2009
    ..Meningitis and sepsis are the most common clinical manifestations of S. suis infection; hearing loss is a frequent complication. In this article, we provide an overview of the emergence and clinical manifestations of S. suis infection...
  36. ncbi Mode of delivery and other maternal factors influence the acquisition of Streptococcus mutans in infants
    Y Li
    Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010 4086, USA
    J Dent Res 84:806-11. 2005
    ..Analysis of the data demonstrated the possible perinatal influences on infants' acquisition of a member of the cariogenic microbiota, and its potential effect on caries outcome...
  37. pmc Multilocus sequence types associated with neonatal group B streptococcal sepsis and meningitis in Canada
    Shannon D Manning
    Department ofPediatrics and Human Development, Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, E Lansing, Michigan 48824, USA
    J Clin Microbiol 47:1143-8. 2009
    ..Further research is required to better understand why strains belonging to the ST-17 phylogenetic lineage are more likely to cause both LOD and meningitis and may provide clues into the pathogenesis of these conditions...
  38. ncbi Evaluation of universal antenatal screening for group B streptococcus
    Melissa K Van Dyke
    Epidemic Intelligence Service Program, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 360:2626-36. 2009
    ..In 2002, national guidelines recommended universal late antenatal screening of pregnant women for colonization with group B streptococcus to identify candidates for intrapartum chemoprophylaxis...
  39. pmc Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics
    Stephen B Beres
    Department of Pathology, The Methodist Hospital, Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:4371-6. 2010
    ..We conclude that enhanced understanding of bacterial epidemics requires a deep-sequencing, geographically centric, comparative pathogenomics strategy...
  40. pmc Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe
    Bogdan Luca-Harari
    Department of Clinical Microbiology and Immunology, Lund University Hospital USIL, Lund, Sweden
    J Clin Microbiol 47:1155-65. 2009
    ..pyogenes within Europe and encourages future surveillance by the notification of cases and the characterization of strains, which are important for vaccination strategies and other health care issues...
  41. pmc Recent advances in understanding the molecular basis of group B Streptococcus virulence
    Heather C Maisey
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0687, USA
    Expert Rev Mol Med 10:e27. 2008
    ..An understanding of the complex interplay between Group B Streptococcus and host provides valuable insight into pathogen evolution and highlights molecular targets for therapeutic intervention...
  42. ncbi Comparative proteome analysis of secreted proteins of Streptococcus suis serotype 9 isolates from diseased and healthy pigs
    Zongfu Wu
    Key Laboratory of Animal Disease Diagnostic and Immunology, Ministry of Agriculture, Nanjing Agricultural University, Weigang 1, Nanjing 210095, Jiangsu, PR China
    Microb Pathog 45:159-66. 2008
    ..These findings contribute to the understanding of SS9 pathogenic mechanisms...
  43. ncbi Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria
    Rita G Kansal
    Department of Veterans Affairs Medical Center, Research Service, University of Tennessee Health Science Center, Memphis, TN 38104, USA
    J Infect Dis 201:855-65. 2010
    ..Correction of the covS mutation in AP bacteria reverted them back to the WT phenotype. Our data confirm that covS plays a direct role in regulating GAS virulence...
  44. ncbi Neutrophil-derived hyperresistinemia in severe acute streptococcal infections
    Linda Johansson
    Department of Medicine F59, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Immunol 183:4047-54. 2009
    ..activation and degranulation as important contributors to disease pathology in invasive group A streptococcal infections has recently been emphasized...
  45. ncbi Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
    Mol Microbiol 54:23-31. 2004
    ..Appreciation of the formidable array of GBS virulence factors underscores why this bacterium remains at the forefront of neonatal pathogens...
  46. ncbi The cation-uptake regulators AdcR and Fur are necessary for full virulence of Streptococcus suis
    Jesús Aranda
    Department de Genètica i Microbiologia, Universitat Autonoma de Barcelona, Bellaterra, 08193 Barcelona, Spain
    Vet Microbiol 144:246-9. 2010
    ..Our data provide evidence that the adcR and fur genes play important roles in the oxidative stress response of S. suis as well as in the full virulence of this bacterium...
  47. ncbi A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sites
    Axel Schubert
    Department of Microbiology and Biotechnology, University of Ulm, Germany
    Mol Microbiol 46:557-69. 2002
    ....
  48. pmc Distribution of serotypes and antimicrobial resistance genes among Streptococcus agalactiae isolates from bovine and human hosts
    Belgin Dogan
    Department of Food Science, 413 Stocking Hall, Cornell University, Ithaca, NY 14853, USA
    J Clin Microbiol 43:5899-906. 2005
    ..agalactiae appears to include both clonal spread of resistant strains as well as horizontal gene transfer...
  49. pmc Maternal and neonatal colonisation of group B streptococcus at Muhimbili National Hospital in Dar es Salaam, Tanzania: prevalence, risk factors and antimicrobial resistance
    Agricola Joachim
    Department of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    BMC Public Health 9:437. 2009
    ....
  50. ncbi Phylogenetic relationships among Streptococcus agalactiae isolated from piscine, dolphin, bovine and human sources: a dolphin and piscine lineage associated with a fish epidemic in Kuwait is also associated with human neonatal infections in Japan
    Joyce J Evans
    United States Department of Agriculture, Agricultural Research Service, Aquatic Animal Health Research Laboratories, Chestertown, MD 21620, USA
    J Med Microbiol 57:1369-76. 2008
    ..Comparative genomics of piscine, human and bovine GBS could help clarify those genes important for host tropism, the emergence of unique pathogenic clones and whether these hosts act as reservoirs of one another's pathogenic lineages...
  51. ncbi Streptococcus australis meningitis
    Genevieve Héry-Arnaud
    Departement de Microbiologie, Centre Hospitalier Régional Universitaire CHRU Brest, France
    J Med Microbiol 60:1701-4. 2011
    ..We report a case of meningitis due to Streptococcus australis, a species of oral streptococcus. Accurate identification was performed by various molecular techniques...
  52. pmc Invasive group B streptococcal infection in infants, Malawi
    Katherine J Gray
    Malawi Liverpool Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi
    Emerg Infect Dis 13:223-9. 2007
    ..Effective locally relevant prevention strategies are needed...
  53. ncbi Nosocomial spread of multidrug-resistant group B streptococci with reduced penicillin susceptibility belonging to clonal complex 1
    Noriyuki Nagano
    Department of Bacteriology II, National Institute of Infectious Diseases, 4 7 1 Musashi murayama, Tokyo 208 0011, Japan
    J Antimicrob Chemother 67:849-56. 2012
    ..Multiple group B Streptococcus (GBS) isolates with reduced penicillin susceptibility (PRGBS) were recovered from several patients, hence a probable nosocomial transmission of PRGBS in a hospital setting was suspected...
  54. pmc Characterization and functional analysis of atl, a novel gene encoding autolysin in Streptococcus suis
    Cun Xiang Ju
    Key Lab of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
    J Bacteriol 194:1464-73. 2012
    ..It takes part in cell autolysis, separation of daughter cells, biofilm formation, fibronectin-binding activity, cell adhesion, and pathogenesis of HA9801...
  55. pmc Streptococcus agalactiae in adults at Chiang Mai University Hospital: a retrospective study
    Romanee Chaiwarith
    Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    BMC Infect Dis 11:149. 2011
    ..This study describes the epidemiological, clinical, and microbiological characteristics of S. agalactiae infection in adult patients in northern Thailand...
  56. pmc Complete genome sequence and immunoproteomic analyses of the bacterial fish pathogen Streptococcus parauberis
    Seong Won Nho
    College of Veterinary Medicine, Gyeongsang National University, Gyeongnam 660 701, South Korea
    J Bacteriol 193:3356-66. 2011
    ..The work also provides a better understanding of the physiology and evolution of a significant representative of the Streptococcaceae...
  57. pmc Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tract
    Tamsin R Sheen
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182, USA
    J Bacteriol 193:6834-42. 2011
    ..Our results suggest that these GBS surface proteins contribute to vaginal colonization and may offer new insights into the mechanisms of vaginal niche establishment...
  58. pmc Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case
    Giuliano Bensi
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Mol Cell Proteomics 11:M111.015693. 2012
    ..This approach may find general application as an accelerated and highly accurate path to bacterial vaccine discovery...
  59. pmc Group B Streptococcus: global incidence and vaccine development
    Atul Kumar Johri
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Nat Rev Microbiol 4:932-42. 2006
    ..This Review highlights efforts towards this goal and describes a template that can be followed to develop vaccines against other bacterial pathogens...
  60. pmc Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish
    Jeffrey B Locke
    Department of Pediatrics, Division of Pharmacology and Drug Discovery, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    J Bacteriol 189:1279-87. 2007
    ..In summary, we report a genetically defined study on the role of capsule in S. iniae virulence and provide preliminary analysis of S. iniae capsular polysaccharide sugar components...
  61. pmc Phenotypic and genotypic characterization of group B streptococcal isolates in southern Brazil
    Jussara K Palmeiro
    Hospital de Clinicas, Departamento de Tocoginecologia, Universidade Federal do Parana, Curitiba, Parana, Brazil
    J Clin Microbiol 48:4397-403. 2010
    ..Furthermore, in a few cases, isolates from the same patients and possessing the same PFGE type were of different serotypes. These findings could be related to the occurrence of capsular switching by horizontal transfer of capsular genes...
  62. pmc Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
    Patrick R Shea
    The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Emerg Infect Dis 17:2010-7. 2011
    ..We also discovered a striking increase in frequency of emm89 strains among isolates from patients with pharyngitis and invasive disease. These findings about the epidemiology of GAS are potentially useful for vaccine research...
  63. pmc Distribution of pilus islands in Streptococcus agalactiae that cause human infections: insights into evolution and implication for vaccine development
    E R Martins
    Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    Clin Vaccine Immunol 20:313-6. 2013
    ..The stability and dominance of PI-1 and PI-2a in multiple serotypes and founder multilocus sequence types disseminated worldwide suggest it could be the PI combination present in ancestral GBS human pathogens...
  64. ncbi Invasive group a streptococcal disease: epidemiology, pathogenesis and management
    Andrew C Steer
    Centre for International Child Health, Department of Paediatrics, The University of Melbourne, Parkville, Vic, Australia
    Drugs 72:1213-27. 2012
    Invasive group A streptococcal infections are uncommon, although serious, infections with high case fatality rates...
  65. pmc Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence
    I Hsuan Lin
    Institute of Biomedical Informatics, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 6:e20519. 2011
    ..gallolyticus biotypes and the type of disease an infected patient eventually develops...
  66. ncbi Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea
    Christine A Kirvan
    California State University, Department of Biological Sciences, Sacramento, CA, USA
    Autoimmunity 39:21-9. 2006
    ..A group of antibodies present in pediatric autoimmune neuropsychiatric disorders (PANDAS) were similar but not identical to the antibodies observed in chorea...
  67. ncbi The role of toll-like receptors in the pathogenesis of Streptococcus suis
    Han Zheng
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China
    Vet Microbiol 156:147-56. 2012
    ..The data suggest that mechanisms of inflammation induced by S. suis strains differ where this will be useful in designing efficient strategies in combating streptococcal toxic shock-like syndrome caused by the S. suis ST7 strains...
  68. ncbi Real-time PCR for detection and differentiation of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus
    V Båverud
    Department of Bacteriology, National Veterinary Institute, SE 751 89 Uppsala, Sweden
    Vet Microbiol 124:219-29. 2007
    ..The real-time PCR system was found to be more sensitive than conventional cultivation as two additional field isolates of S. equi and four of S. zooepidemicus were detected...
  69. ncbi Invasive group A streptococcal infections: T1M1 isolates expressing pyrogenic exotoxins A and B in combination with selective lack of toxin-neutralizing antibodies are associated with increased risk of streptococcal toxic shock syndrome
    B K Eriksson
    Division of Infectious Diseases, Department of Immunology, Karolinska Institute, Huddinge University Hospital, Sweden
    J Infect Dis 180:410-8. 1999
    ..Neutralization of SpeB was significantly lower in sera of patients with STSS than in sera from persons with bacteremia or erysipelas...
  70. pmc The putative glycosyltransferase-encoding gene cylJ and the group B Streptococcus (GBS)-specific gene cylK modulate hemolysin production and virulence of GBS
    Marie Pierre Forquin
    Unité de Biologie des Bactéries Pathogènes à Gram Positif, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 75:2063-6. 2007
    ..cylJ, encoding a putative glycosyltransferase, and cylK, whose product is unknown, are both required for the full hemolytic/cytolytic activity, pigment formation, and virulence of GBS...
  71. pmc Streptolysin O inhibits clathrin-dependent internalization of group A Streptococcus
    Lauren K Logsdon
    Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    MBio 2:e00332-10. 2011
    ..We conclude that SLO interferes with the internalization of GAS through local perturbation of the keratinocyte cell membrane and disruption of a clathrin-dependent uptake pathway...
  72. ncbi Post-streptococcal glomerulonephritis is a strong risk factor for chronic kidney disease in later life
    Wendy E Hoy
    Centre for Chronic Disease, University of Queensland, Herston, Queensland, Australia
    Kidney Int 81:1026-32. 2012
    ..Thus, PSGN contributes to the very serious burden of chronic kidney disease in this community. Rigorous strategies to prevent scabies and Group A streptococcal infections will reduce this burden.
  73. ncbi Isolation and characterization of alpha-enolase, a novel fibronectin-binding protein from Streptococcus suis
    Miriam Esgleas
    Groupe de Recherche sur les Maladies Infectieuses du Porc GREMIP and Centre de Recherche en Infectiologie Porcine CRIP, Faculte de Medecine Veterinaire, Universite de Montreal, Quebec, Canada
    Microbiology 154:2668-79. 2008
    ..suis...
  74. ncbi Streptococcus iniae: an aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination
    Wendy Agnew
    School of Veterinary Science, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Vet Microbiol 122:1-15. 2007
    ..iniae and associated economic losses continue to increase, further work towards developing a reliable vaccine is essential. This would appear to require a much better understanding of cell-surface variability amongst S. iniae isolates...
  75. ncbi DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection
    Mark J Walker
    School of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Nat Med 13:981-5. 2007
    ..The results provide a paradigm whereby natural selection exerted by the innate immune system generates hypervirulent bacterial variants with increased risk of systemic dissemination...
  76. pmc Identification of novel LPXTG-linked surface proteins from Streptococcus gordonii
    Julia R Davies
    Department of Oral Biology, Faculty of Odontology, Malmo University, Carl Gustavs väg 34, Malmö S 20506, Sweden
    Microbiology 155:1977-88. 2009
    ..gordonii DL1 cell surface, the expression of which plays an important role in adhesion to epithelia and which represent likely candidates for novel virulence factors in S. gordonii...
  77. pmc DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition
    Satoshi Uchiyama
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    PLoS Pathog 8:e1002736. 2012
    ..Our results demonstrate a novel mechanism of bacterial innate immune evasion based on autodegradation of CpG-rich DNA by a bacterial DNase...
  78. ncbi Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis
    Nahuel Fittipaldi
    Groupe de Recherche sur les Maladies Infectieuses du Porc and Centre de Recherche en Infectiologie Porcine, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, CP5000, St Hyacinthe, Quebec, J2S 7C6, Canada
    Future Microbiol 7:259-79. 2012
    ..suis infection has not yet been clearly established...
  79. ncbi Macrolide resistance in Streptococcus pyogenes: prevalence, resistance determinants, and emm types
    Athanasios G Michos
    First Department of Pediatrics, Aghia Sophia Children s Hospital, Athens University, Greece
    Diagn Microbiol Infect Dis 64:295-9. 2009
    ..8%), 12 (17.5%), 28 (13.8%). The observed antimicrobial resistance trends and the distribution of specific emm types have implications in guiding empiric therapy and in developing vaccine strategies to prevent GAS infections...
  80. ncbi Surveillance for hospital outbreaks of invasive group a streptococcal infections in Ontario, Canada, 1992 to 2000
    Nick Daneman
    University of Toronto, Mount Sinai Hospital, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ann Intern Med 147:234-41. 2007
    ..Streptococcus pyogenes can cause severe disease in the individual patient and dramatic hospital outbreaks...
  81. ncbi The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications
    Dwight R Johnson
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Clin Infect Dis 50:481-90. 2010
    ..Although the importance of immunologic confirmation of infection is widely accepted, the immediate and long-term immunokinetics of the human antibody response are incompletely documented and poorly understood...
  82. ncbi Novel clues on the specific association of Streptococcus gallolyticus subsp gallolyticus with colorectal cancer
    Annemarie Boleij
    Department of Laboratory Medicine, Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 203:1101-9. 2011
    ..Therefore, this study aimed to reveal the virulence characteristics that distinguish this opportunistic pathogen from a panel of (closely related) intestinal bacteria...
  83. pmc Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection
    Kimberly A Kline
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Infect Immun 79:3588-95. 2011
    ..These studies define several basic molecular and cellular events characterizing GBS UTI in an animal model, showing that GBS participates simultaneously in the activation and suppression of host immune responses in the urinary tract...
  84. ncbi Comparison of BD GeneOhm real-time polymerase chain reaction with chromogenic and conventional culture methods for detection of group B Streptococcus in clinical samples
    Dawn Smith
    Microbiology Department, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK
    Diagn Microbiol Infect Dis 61:369-72. 2008
    ..5% versus 57% respectively, P < 0.02). After selective enrichment, 92.8% of GBS were isolated on chromID Strepto B compared with 89.2% isolated on sheep blood agar...
  85. pmc Genetic diversity of Streptococcus suis isolates as determined by comparative genome hybridization
    Astrid De Greeff
    Infection Biology, Central Veterinary Institute of Wageningen UR University and Research Centre, Edelhertweg 15, Lelystad, 8219 PH, The Netherlands
    BMC Microbiol 11:161. 2011
    ..S. suis is a heterogeneous species. Thirty-three different capsular serotypes have been described, that differ in virulence between as well as within serotypes...
  86. pmc Risk factors of Streptococcus suis infection in Vietnam. A case-control study
    Ho Dang Trung Nghia
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS ONE 6:e17604. 2011
    ..Little is known of the risk factors underlying the disease...
  87. pmc The validity of a sore throat score in family practice
    W J McIsaac
    Family Medicine Centre, Mount Sinai Hospital, Toronto, Ont
    CMAJ 163:811-5. 2000
    ..The study also examined the potential impact of this clinical score on the prescribing of antibiotics in community-based family practice...
  88. ncbi Streptococcus equi subspecies zooepidemicus meningitis--a case report and review of the literature
    D W Eyre
    Infectious Diseases and Medical Microbiology, John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust, Headington, Oxford OX3 9DU, UK
    Eur J Clin Microbiol Infect Dis 29:1459-63. 2010
    ..Only 38% of patients made a complete recovery. Treatment regimes commonly included benzylpenicillin or a third-generation cephalosporin, with a mean treatment duration in survivors of 23 days...
  89. ncbi Burden of acute sore throat and group A streptococcal pharyngitis in school-aged children and their families in Australia
    Margaret H Danchin
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Pediatrics 120:950-7. 2007
    ..The objective of this study was to determine the incidence, transmission, carriage, and risk factors for group A streptococcal pharyngitis in school-aged children and their families...
  90. pmc Incidence and pathogenic effect of Streptococcus pseudopneumoniae
    Colette Harf-Monteil
    Institute of Bacteriology, UPRES EA 3432, Louis Pasteur University, Strasbourg University Hospital, Strasbourg, France
    J Clin Microbiol 44:2240-1. 2006
    ..The pathogenic role of this organism was investigated with the mouse peritonitis/sepsis model. Our results show a low incidence (1/120 pneumococcal isolates) and a potential pathogenic effect for S. pseudopneumoniae...
  91. pmc Highly penicillin-resistant multidrug-resistant pneumococcus-like strains colonizing children in Oeiras, Portugal: genomic characteristics and implications for surveillance
    Alexandra S Simões
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras 2780 156, Portugal
    J Clin Microbiol 48:238-46. 2010
    ..In our study, after correct identification of the penicillin-resistant true pneumococci, we found that penicillin resistance levels among pneumococci remained stable from 2003 to 2006...
  92. pmc Diversity of group B streptococcus serotypes causing urinary tract infection in adults
    Kimberly B Ulett
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Clin Microbiol 47:2055-60. 2009
    ..Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS...
  93. pmc Group B streptococcus and early-onset sepsis in the era of maternal prophylaxis
    Joyce M Koenig
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Saint Louis University, Saint Louis, MO 63104, USA
    Pediatr Clin North Am 56:689-708, Table of Contents. 2009
    ..Modern technologies, such as those involving proteomics and genomic sequencing, are likely to hasten the development of a universal vaccine against GBS...
  94. ncbi In vitro antimicrobial susceptibility of Streptococcus suis strains isolated from clinically healthy sows in China
    Chunping Zhang
    College of Veterinary Medicine, China Agricultural University, Beijing, China
    Vet Microbiol 131:386-92. 2008
    ..5% and 42.3%), ampicillin (4.0% and 29.9%) and ceftiofur (22.1% and 37.3%), respectively...
  95. ncbi Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes
    Chuan Chiang-Ni
    Institute of Basic Medical Sciences, Department of Medical Laboratory Science and Biotechnology, Medical College, National Cheng Kung University, Tainan, Taiwan
    J Formos Med Assoc 107:677-85. 2008
    ..Here, we review several publications and describe our current understanding of SpeB in GAS pathogenesis...
  96. pmc Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis
    Marisa Haenni
    Unité Antibiorésistance et Virulence Bactériennes, Anses Lyon, 31 avenue Tony Garnier, F 69364 Lyon Cedex 07, France
    Appl Environ Microbiol 76:7957-65. 2010
    ..These ICEs could thus also be a vehicle for horizontal gene transfer between streptococci of animal and/or human origin...
  97. pmc Response of swine spleen to Streptococcus suis infection revealed by transcription analysis
    Ran Li
    Unit of Animal Infectious Diseases, National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, China
    BMC Genomics 11:556. 2010
    ..Systematical information about host immune response to the infection is important for understanding the molecular mechanism of diseases...
  98. ncbi Clonal dissemination of human isolates of Streptococcus suis serotype 14 in Thailand
    Anusak Kerdsin
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Tiwanon Road, Muang, Nonthaburi 11000, Thailand
    J Med Microbiol 58:1508-13. 2009
    ..Because serotype 14 is becoming a more common cause of S. suis infections in humans, diagnostic tests for serotype 14 should be performed in South-East Asian countries...
  99. pmc Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and
    Kasey M Moyes
    Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
    BMC Genomics 10:542. 2009
    ..uberis and relate these with other physiological measurements associated with immune and/or metabolic responses to mastitis challenge with S. uberis O140J...
  100. ncbi Streptococcus suis meningitis in adults in Vietnam
    Nguyen Thi Hoang Mai
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Clin Infect Dis 46:659-67. 2008
    ..Streptococcus suis infection is an emerging zoonosis in Asia. We determined the detailed epidemiological, clinical, and microbiological characteristics of S. suis meningitis in adults...
  101. pmc Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group
    Calum Johnston
    Division of Infection and Immunity, University of Glasgow, B2 28, GBRC, 120 University Place, Glasgow G12 8TA, United Kingdom
    J Clin Microbiol 48:2762-9. 2010
    ..In contrast, the nanA gene sequences in the pneumococcus and streptococci from the mitis group are closely clustered together, sharing 99.4 to 99.7% sequence identity with pneumococcal nanA alleles...

Research Grants62

  1. Metal-dependent phosphohydrolase activity of CvfA from Streptococcus pyogenes
    GABRIELA CITLALLI PEREZ-ALVARADO; Fiscal Year: 2012
    ..The impact of our results will lead to new therapeutic strategies against streptococcal infections following three potential approaches: 1) interference with RNA recognition by the KH domain, 2) down ..
  2. Role of Immunogenetic Factors in Invasive Streptococcal Infections
    MALAK Y S KOTB; Fiscal Year: 2012
    ....
  3. SpyA, a novel S. pyogenes ADP-ribosyltransferase
    STEPHEN L MOSELEY; Fiscal Year: 2010
    ..The goals of this grant are (1) to determine the role of SpyA in streptococcal infections, (2) to characterize its novel entry mechanism and (3) to characterize the structure and biochemical ..
  4. Chronic Ethanol Consumption and Pulmonary Immune Suppression
    Kevin L Legge; Fiscal Year: 2013
    ..Given the current threat of both epidemic and pandemic influenza as well as the ongoing threat of Streptococcal infections in alcoholics a better understanding of the alcohol induced lesions within the pulmonary adaptive immune ..
  5. EMERGING INFECTIONS PROGRAM
    Timothy F Jones; Fiscal Year: 2011
    ..influenzae and groups A and B streptococcal infections as well as foodbome illnesses such as E...
  6. MOLECULAR MECHANISMS OF FIBRINOLYSIS
    Paul E Bock; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Severe streptococcal infections account for more than 500,000 deaths globally per year...
  7. Role of M-Related Protein and IgG Interactions in Virulence of S. pyogenes
    Harry S Courtney; Fiscal Year: 2013
    ..A clear understanding of the mechanisms whereby Mrp contributes to the pathogenesis of streptococcal infections will help in devising methods to thwart these mechanisms...
  8. Vaccine Prevention of Group A Streptococcal Infections
    James B Dale; Fiscal Year: 2013
    ....
  9. Passive Immunotherapy for Pediatric Mutans Streptococcal Infections
    Martin Taubman; Fiscal Year: 2009
    ..abstract_text> ..
  10. CHEMISTRY AND IMMUNOLOGY OF STREPTOCOCCAL M PROTEINS
    James B Dale; Fiscal Year: 2010
    ..overall goal of this project is to develop a safe and broadly effective vaccine that will prevent group A streptococcal infections. Previous studies have shown that the surface M proteins, which are the major protective antigens, ..
  11. INTERACTION OF GROUP A STREP WITH THE PLASMINOGEN SYSTEM
    Michael Boyle; Fiscal Year: 2001
    ..With the reported increase in mortality and morbidity associated with invasive streptococcal infections, a more comprehensive understanding of the pathogenic process is important.
  12. SYNTHETIC PEPTIDE VACCINES FOR DENTAL CARIES
    Martin Taubman; Fiscal Year: 2005
    ..vectors, and strategies which have the best chance of inducing protective immune responses to mutans streptococcal infections in susceptible pediatric populations...
  13. STREPTOCOCCAL HYALURONATE CAPSULE
    Ivo van de Rijn; Fiscal Year: 1999
    ..Within the last decade, an increase in the number of invasive group A streptococcal infections associated with bacteremia deep soft-tissue infection, shock, and multi- organ failure were observed in ..
  14. STREP, HOST FACTORS, AUTOANTIBODIES & TOURETTE SYNDROME
    Harvey Singer; Fiscal Year: 2000
    ..aims of this proposal are, in a cohort study, to examine the relative contribution of ANAb levels and streptococcal infections to exacerbations of tics in 50 children with TS-like PANDAS, 50 with TS-nonPANDAS, and 50 Controls (ages ..
  15. MOLECULAR INTERACTIONS BETWEEN SPEA AND THE TCR
    CARLEEN COLLINS; Fiscal Year: 2002
    ..and the designation streptococcal toxic shock syndrome (STSS) has been assigned to these invasive streptococcal infections. There is strong epidemiologic evidence implicating streptococcal pyrogenic exotoxin A (SpeA) in the ..
  16. DETERMINANTS OF VIRULENCE IN GROUP A STREPTOCOCCI
    JOSEPH FERRETTI; Fiscal Year: 2002
    ..In spite of intense investigation by a number of laboratories, the periodic increase in severe streptococcal infections and the factors associated with these infections remain poorly understood...
  17. MUCOID VARIANTS OF S PYOGENES EXHIBIT ENHANCED VIRULENCE
    N Engleberg; Fiscal Year: 2001
    ..5) Finally, we propose to study human isolates from patients with invasive and non-invasive streptococcal infections to determine whether subpopulations of csrRS mutant bacteria are a common feature of these life-..
  18. Response of Streptococcus pyogenes to Nutritional Stress
    JOSEPH FERRETTI; Fiscal Year: 2005
    ..This knowledge will help understand pathogenetic mechanisms and may even lead to new approaches for treatment or prevention of streptococcal infections.
  19. THE ROLE OF IGA IN BACTERIAL DISEASE
    JOHN GRIFFISS; Fiscal Year: 1993
    ..pathogenesis of epidemic meningococcal disease and may be involved in that of gonococcal, Haemophilus and streptococcal infections, as well. It is also probable that it contributes to sepsis during severe hepatic cirrhosis...
  20. MOLECULAR BASIS OF LUNG INJURY IN GBS PNEUMONIA
    Victor Nizet; Fiscal Year: 2000
    ..from the University of Washington in 1982. Dr. Nizet will examine the role of beta hemolysin in group B streptococcal infections and its ability to cause cellular damage in the lung...
  21. MECHANISMS OF STREPTOCOCCAL-HOST INTERACTIONS
    JOHN ZABRISKIE; Fiscal Year: 1993
    ..We will also determine whether antigen expression is influenced by streptococcal infections,immunosuppressive agents and whether it is present in other presumed autoimmune diseases. 2...
  22. Iron acquisition in Streptococcus pyogenes
    GRISELLE MONTANEZ; Fiscal Year: 2004
    ..An unexplained increase in the frequency and severity of streptococcal infections has been observed since the 1980s. The hemolytic S...
  23. Streptococcal-Zebrafish Model of Bacterial Pathogenesis
    MELODY NEELY; Fiscal Year: 2002
    ..and humans and that mediate disease states in the zebrafish that are identical to those found in human streptococcal infections, we will be able to identify common virulence strategies shared by a number of Gram positive pathogens...
  24. Streptococcal-Zebrafish Model of Bacterial Pathogenesis
    MELODY NEELY; Fiscal Year: 2006
    ..and humans and that mediate disease states in the zebrafish that are identical to those found in human streptococcal infections, we will be able to identify common virulence strategies shared by a number of Gram positive pathogens...
  25. CELL SURFACE OF STREPTOCOCCI
    MACLYN MC CARTY; Fiscal Year: 1980
    ..The ultimate goal is to elucidate the mechanisms involved in pathogenesis of the major sequelae of streptococcal infections: rheumatic fever and glomerulonephritis...
  26. THE STREPTOCOCCAL INITIATIVE
    Dennis Kasper; Fiscal Year: 2000
    ..highest priority for investigation in the contract renewal period: (1) study of pathogenic mechanisms of streptococcal infections (GBS and GAS); (2) epidemiologic surveillance (GBS); (3) production and human testing of vaccines (GBS); ..
  27. MUCOID VARIANTS OF S PYOGENES EXHIBIT ENHANCED VIRULENCE
    N Engleberg; Fiscal Year: 1999
    ..Understanding the mechanism of severe streptococcal infections may lead to the identification of novel targets for specific therapy of a disease that causes severe ..
  28. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2009
    ..abstract_text> ..
  29. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2004
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
  30. Molecular Evolution of Resistance in Strep. pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
    ..GAS provide a sound model system for understanding the molecular evolution underlying the early stages of the emergence and global spread of antibiotic resistance. ..
  31. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2007
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  32. Oral and Vaginal Microbes, Human Genotype, and Preterm Birth
    Dawn P Misra; Fiscal Year: 2010
    ..For this proposal we have the great advantage of exploring these hypotheses using already collected specimens and data as part of completed studies of preterm birth. ..
  33. Measuring Quality - The Impact of Patient Complexity
    Robert Centor; Fiscal Year: 2007
    ..Finally, we hope to present an economical research agenda to the research community and AHRQ at the national meeting. [unreadable] [unreadable] [unreadable]..
  34. GBS: Epidemiologic Characterization for Gene Discovery
    Betsy Foxman; Fiscal Year: 2007
    ..A better understanding of the molecular epidemiology and the identification of new GBS virulence genes will facilitate the discover of new therapies and prevention strategies for GBS disease. ..
  35. Pharmacogenetics in Tourette Syndrom
    Harvey Singer; Fiscal Year: 2004
    ..The identification of genetic polymorphisms that are associated with clinical disease or treatment success, has obvious benefits. ..
  36. NEUROIMMUNOLOGY OF CHILDHOOD PSYCHIATRIC DISORDERS
    Tanya Murphy; Fiscal Year: 2005
    ..This award, along with support from the University Florida Brain Institute and the Department of Psychiatry, will enable the candidate to build a strong foundation of research skills needed to become an independent investigator. ..
  37. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2003
    ....
  38. Mechanisms of Tandem Repeat Deletion in Group B Strep
    KAREN PUOPOLO; Fiscal Year: 2006
    ..The training goal of this project is to prepare the applicant for a career in bacterial genetic research by providing didactic education and the opportunity to develop laboratory expertise in this rapidly evolving field. ..
  39. Prospective Study of 'PANDAS'
    Tanya Murphy; Fiscal Year: 2006
    ..The results will help determine if antimicrobial interventions are warranted in certain subtypes of pediatric OCD or TS. ..
  40. A Prospective Longitudinal Study of PANDAS
    James Leckman; Fiscal Year: 2005
    ..identified by the acronym PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) follows a unique clinical course...
  41. GROUP A STREPTOCOCCAL INFECTIONS IN CHILDREN
    Judith Martin; Fiscal Year: 2004
    ....
  42. Therapeutic vaccine against tuberculosis
    Lee Riley; Fiscal Year: 2006
    ..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
  43. n-3 Fatty Acid & Host Responses to Oral Infection
    KESAVALU LAKSHMYYA; Fiscal Year: 2003
    ..Positive findings could enable improved dietary strategies as adjuncts in the prevention of periodontal disease. ..
  44. In vivo regulation of M. tuberculosis cell wall lipids
    Lee W Riley; Fiscal Year: 2010
    ..tuberculosis and granulomas may contribute to our understanding of the mechanism of persistence of M. tuberculosis that could lead to new tests to differentiate active TB from latent TB infection. ..
  45. Protein Translocation by the Type III Secretion System
    Partho Ghosh; Fiscal Year: 2010
    ..Our proposal is aimed at understanding how this injection process occurs, and results from our studies are likely to be valuable in the design of antimicrobial strategies aimed at combating these pathogens. ..
  46. Mechanism of Host Cell Invasion by Microbial Pathogens
    Partho Ghosh; Fiscal Year: 2010
    ..In addition, the particular pathogen we are studying, Listeria monocytogenes, affects a protein called Met that is involved in some cancers. Thus, results from our studies may also have an impact on cancer therapies. ..
  47. Family Based Treatment of Early Childhood OCD
    Henrietta Leonard; Fiscal Year: 2004
    ..At the end of the study, a final revised, comprehensive, manualized treatment protocol would be completed which could be tested in large efficacy and effectiveness studies. ..
  48. D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
    Eric Storch; Fiscal Year: 2007
    ..Such agents may have utility in improving outcome, reducing premature therapy termination, and targeting patients who have been treatment refractory. [unreadable] [unreadable] [unreadable]..
  49. Streptococcal genomics and pathogenesis
    Todd Kitten; Fiscal Year: 2007
    ..abstract_text> ..
  50. HOUSTON CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE PLANNING GRANT
    JAMES MUSSER; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  51. GENETICS OF ADHD
    Josephine Elia; Fiscal Year: 2007
    ..Dr. Douglas Levinson will provide mentoring in statistical methods and data analyses and Dr. Judith Rapoport will provide mentoring in defining novel phenotypic definitions for ADHD. ..
  52. MOLECULAR BIOLOGY OF INFECTION WITH M TUBERCULOSIS
    Lee Riley; Fiscal Year: 2002
    ..In addition, these studies may identify several potential targets for new chemotherapeutic agents or vaccine candidates. ..
  53. Development of a Global GBS Vaccine
    LAWRENCE PAOLETTI; Fiscal Year: 2007
    ..This work will lead to a vaccine effective in preventing GBS diseases worldwide. ..
  54. Patterns of Service Use and Costs Associated with Autism
    Douglas Leslie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..Results will provide specific information for determination of the dose and temporal administration of agonist in future clinical trials to treat patients with salivary hypofunction. ..
  56. Srv is critical for Streptococcal survival in the host
    SEAN REID; Fiscal Year: 2009
    ..Understanding the mechanism of Srv-dependent gene regulation will provide new insights into the control of GAS disease. ..