staphylococcal infections

Summary

Summary: Infections with bacteria of the genus STAPHYLOCOCCUS.

Top Publications

  1. pmc Evolution of MRSA during hospital transmission and intercontinental spread
    Simon R Harris
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK
    Science 327:469-74. 2010
  2. ncbi Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    R Monina Klevens
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    JAMA 298:1763-71. 2007
  3. pmc Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
    J Clin Microbiol 38:1008-15. 2000
  4. pmc Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic
    Michael Z David
    Department of Pediatrics and Department of Medicine, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Clin Microbiol Rev 23:616-87. 2010
  5. pmc Waves of resistance: Staphylococcus aureus in the antibiotic era
    Henry F Chambers
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Nat Rev Microbiol 7:629-41. 2009
  6. pmc Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management
    Dag Harmsen
    Institute for Hygiene, University of Munster, Munster, Germany
    J Clin Microbiol 41:5442-8. 2003
  7. ncbi The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
  8. pmc Community-associated meticillin-resistant Staphylococcus aureus
    Frank R Deleo
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Lancet 375:1557-68. 2010
  9. ncbi Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004
    Rachel J Gorwitz
    National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 197:1226-34. 2008
  10. pmc A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus
    Stefan Monecke
    Institute for Medical Microbiology and Hygiene, Technical University of Dresden, Dresden, Germany
    PLoS ONE 6:e17936. 2011

Detail Information

Publications279 found, 100 shown here

  1. pmc Evolution of MRSA during hospital transmission and intercontinental spread
    Simon R Harris
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK
    Science 327:469-74. 2010
    ..The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology...
  2. ncbi Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    R Monina Klevens
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    JAMA 298:1763-71. 2007
    ..As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed...
  3. pmc Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
    M C Enright
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
    J Clin Microbiol 38:1008-15. 2000
    ..MLST provides an unambiguous method for assigning MRSA and MSSA isolates to known clones or assigning them as novel clones via the Internet...
  4. pmc Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic
    Michael Z David
    Department of Pediatrics and Department of Medicine, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Clin Microbiol Rev 23:616-87. 2010
    ..It also addresses the therapy of these infections and strategies for their prevention...
  5. pmc Waves of resistance: Staphylococcus aureus in the antibiotic era
    Henry F Chambers
    Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Nat Rev Microbiol 7:629-41. 2009
    ..Here, we review the molecular epidemiology of the epidemic waves of penicillin- and methicillin-resistant strains of S. aureus that have occurred since 1940, with a focus on the clinical and molecular epidemiology of CA-MRSA...
  6. pmc Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management
    Dag Harmsen
    Institute for Hygiene, University of Munster, Munster, Germany
    J Clin Microbiol 41:5442-8. 2003
    ..spa typing was valuable for tracking of epidemic isolates. The data show that disproval of epidemiologically suggested transmissions of MRSA is one of the main objectives of spa typing in departments with a high incidence of MRSA...
  7. ncbi The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
    ..We present an overview of the current knowledge of the determinants (both human and bacterial) and risks of S aureus nasal carriage. Studies on the population dynamics of S aureus are also summarised...
  8. pmc Community-associated meticillin-resistant Staphylococcus aureus
    Frank R Deleo
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Lancet 375:1557-68. 2010
    ..Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections...
  9. ncbi Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004
    Rachel J Gorwitz
    National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 197:1226-34. 2008
    ..Staphylococcus aureus is a common cause of infection, particularly in persons colonized by this organism. Virulent strains of methicillin-resistant S. aureus (MRSA) have emerged in the general community...
  10. pmc A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus
    Stefan Monecke
    Institute for Medical Microbiology and Hygiene, Technical University of Dresden, Dresden, Germany
    PLoS ONE 6:e17936. 2011
    ..The data also indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements...
  11. pmc Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study
    Laura García-Álvarez
    Department of Veterinary Medicine, University of Cambridge, UK
    Lancet Infect Dis 11:595-603. 2011
    ....
  12. pmc Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis
    Hajo Grundmann
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS Med 7:e1000215. 2010
    ..We aimed to map the geographic distribution of the dominant clones that cause invasive infections in Europe...
  13. pmc Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005
    Eili Klein
    Resources for the Future, Washington DC, USA
    Emerg Infect Dis 13:1840-6. 2007
    ..Our findings suggest that S. aureus and MRSA should be considered a national priority for disease control...
  14. ncbi Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Nat Med 13:1510-4. 2007
    ..Our study reveals a previously uncharacterized set of S. aureus virulence factors that account at least in part for the enhanced virulence of CA-MRSA...
  15. ncbi Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus
    Binh An Diep
    Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94143, USA
    Lancet 367:731-9. 2006
    ..Our aim was to sequence its genome and compare it with those of other strains of S aureus to try to identify genes responsible for its distinctive epidemiological and virulence properties...
  16. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
    ..While spa-type t108 is apparently a more widespread clone among pig farmers and their environment, we did find other spa-types...
  17. pmc Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus
    Bethan V Lowder
    The Roslin Institute and Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH8 9YL, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 106:19545-50. 2009
    ..These data provide a new paradigm for the impact of human activities on the emergence of animal pathogens...
  18. pmc Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database
    Linda K McDougal
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:5113-20. 2003
    ..Noticeably absent from the U.S. database were isolates with the previously described Brazilian and EMRSA15 PFGE patterns. These data suggest that there are a limited number of ORSA genotypes present in the United States...
  19. ncbi Treatment of infections associated with surgical implants
    Rabih O Darouiche
    Center for Prostheses Infection and the Infectious Disease Section, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 350:1422-9. 2004
  20. ncbi Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children
    Catherine Liu
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, California94102, USA
    Clin Infect Dis 52:e18-55. 2011
    ..Recommendations are provided regarding vancomycin dosing and monitoring, management of infections due to MRSA strains with reduced susceptibility to vancomycin, and vancomycin treatment failures...
  21. pmc MRSA harboring mecA variant gene mecC, France
    Frederic Laurent
    Centre de Reference des Staphylocoques, Centre de Biologie Nord, Groupement Hospitalier Nord, 103 Grande Rue de la Croix Rousse, Lyon 69004, France
    Emerg Infect Dis 18:1465-7. 2012
    ..Our report confirms that this new variant has a large distribution in Europe. It may represent a public health threat because phenotypic and genotypic tests seem unable to detect this new resistance mechanism...
  22. ncbi Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    N Engl J Med 344:11-6. 2001
    ..We examined S. aureus isolates from blood and from nasal specimens to determine whether the organisms in the bloodstream originated from the patient's own flora...
  23. ncbi Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia
    G Lina
    Centre National de Référence de Toxémies Staphylococciques, Faculte de Medecine, 69372 Lyon Cedex 08, France
    Clin Infect Dis 29:1128-32. 1999
    ..It thus appears that PVL is mainly associated with necrotic lesions involving the skin or mucosa...
  24. ncbi Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection
    Timothy S Naimi
    Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
    JAMA 290:2976-84. 2003
    ..However, MRSA has emerged in patients without established risk factors (community-associated MRSA)...
  25. ncbi Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study
    Jae Hoon Song
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Antimicrob Chemother 66:1061-9. 2011
    ..aureus infections. To understand the changing epidemiology of S. aureus infections in Asian countries, we performed a prospective, multinational surveillance study with molecular typing analysis...
  26. pmc Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus
    Anna C Shore
    Microbiology Research Unit, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Dublin, Ireland
    Antimicrob Agents Chemother 55:3765-73. 2011
    ..aureus strains were predominantly from bovine sources. The highly divergent nature of SCCmec XI relative to other SCCmec elements indicates that it may have originated in another taxon...
  27. ncbi Transmissibility of livestock-associated methicillin-resistant Staphylococcus aureus (ST398) in Dutch hospitals
    M W M Wassenberg
    Department of Medical Microbiology, University Medical Centre Utrecht, The Netherlands
    Clin Microbiol Infect 17:316-9. 2011
    ..28 (95% CI 0.09-0.90), which was not sensitive to adjustment for duration of hospitalization at time of detection. Nosocomial transmission of ST398 MRSA is 72% less likely than that of non-ST398 MRSA strains...
  28. pmc Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR
    Benjamin P Howden
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    PLoS Pathog 7:e1002359. 2011
    ..aureus infections and demonstrates the role played by walKR to increase drug resistance, control metabolism and alter the virulence potential of this pathogen...
  29. ncbi Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers
    Heiman F L Wertheim
    Erasmus MC, University Medical Centre, Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
    Lancet 364:703-5. 2004
    ..006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous...
  30. ncbi Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillanc
    D J Diekema
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Clin Infect Dis 32:S114-32. 2001
    ..Given the increasing multidrug resistance among staphylococci and the possible emergence of vancomycin-resistant strains, global strategies are needed to control emergence and spread of multiply resistant staphylococci...
  31. ncbi Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
    Ulrich Seybold
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Clin Infect Dis 42:647-56. 2006
    ..Whether community-associated methicillin-resistant Staphylococcus aureus (MRSA) genotypes (e.g., USA300) are a major cause of bloodstream infections (BSIs) and health care-associated infections has been poorly defined...
  32. pmc The nosocomial transmission rate of animal-associated ST398 meticillin-resistant Staphylococcus aureus
    Martin C J Bootsma
    Faculty of Science, Department of Mathematics, Utrecht University, CD Utrecht, The Netherlands
    J R Soc Interface 8:578-84. 2011
    ..The R(A) ratio between non-ST398 MRSA and ST398 was 5.90 (95% CI 2.24-23.81). ST398 is 5.9 times less transmissible than non-ST398 MRSA in Dutch hospitals, which may allow less stringent transmission-control measures for ST398 MRSA...
  33. ncbi Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
    Sara E Cosgrove
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 36:53-9. 2003
    ..54-2.42; P<.001); significant heterogeneity was present. We explored the reasons for heterogeneity by means of subgroup analyses. MRSA bacteremia is associated with significantly higher mortality rate than is MSSA bacteremia...
  34. ncbi Livestock-associated methicillin-resistant Staphylococcus aureus in animals and humans
    Haitske Graveland
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, P O Box 80 176, 3508 TD Utrecht, The Netherlands
    Int J Med Microbiol 301:630-4. 2011
    ..Ongoing MRSA surveillance in humans and animals is needed to detect changes in epidemiology and to implement effective control measures...
  35. pmc Staphylococcus epidermidis--the 'accidental' pathogen
    Michael Otto
    National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 9000 Rockville Pike Building 33 1W10, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 7:555-67. 2009
    ..epidermidis in balancing the epithelial microflora and serving as a reservoir of resistance genes. In this Review, I discuss the molecular basis of the commensal and infectious lifestyles of S. epidermidis...
  36. pmc Staphylococcal biofilms
    M Otto
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA
    Curr Top Microbiol Immunol 322:207-28. 2008
    ..These recent advances constitute an important basis for the development of anti-staphylococcal drugs and vaccines...
  37. ncbi Autoinduction and signal transduction in the regulation of staphylococcal virulence
    Richard P Novick
    Program in Molecular Pathogenesis, Skirball Institute, Department of Microbiology, New York University School of Medicine, 10016, USA
    Mol Microbiol 48:1429-49. 2003
    ..This review is an attempt to integrate a large body of data into the beginnings of a model that will hopefully help to guide research towards a full-scale test...
  38. pmc How clonal is Staphylococcus aureus?
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    J Bacteriol 185:3307-16. 2003
    ....
  39. pmc Antimicrobial resistance: the example of Staphylococcus aureus
    Franklin D Lowy
    Departments of Medicine and Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 111:1265-73. 2003
  40. ncbi Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 194:1761-70. 2006
    ..Although the toxin may be a highly linked epidemiological marker for CA-MRSA strains, we conclude that PVL is not the major virulence determinant of CA-MRSA...
  41. ncbi Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
    ..This study was performed to provide additional insight into staphylococcal carriage types...
  42. pmc NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation
    Petr Hruz
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:12873-8. 2009
    ....
  43. pmc Age- and gender-associated Staphylococcus aureus spa types found among nasal carriers in a general population: the Tromso Staph and Skin Study
    Maria Sangvik
    Research Group for Host Microbe Interactions, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
    J Clin Microbiol 49:4213-8. 2011
    ..This may provide valuable clues to the multifactorial mechanisms, among them bacterial factors, involved in nasal colonization with S. aureus...
  44. ncbi Rapid detection, differentiation and typing of methicillin-resistant Staphylococcus aureus harbouring either mecA or the new mecA homologue mecA(LGA251)
    M Stegger
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark
    Clin Microbiol Infect 18:395-400. 2012
    ..Over a 2-month period, among 203 samples tested, 12 new MRSA cases caused by isolates carrying mecA(LGA251) were identified, emphasizing the clinical importance of testing for these new MRSA isolates...
  45. ncbi Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat
    Hajo Grundmann
    Centre for Infectious Diseases Epidemiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Lancet 368:874-85. 2006
    ....
  46. pmc The innate immune modulators staphylococcal complement inhibitor and chemotaxis inhibitory protein of Staphylococcus aureus are located on beta-hemolysin-converting bacteriophages
    Willem J B Van Wamel
    Eijkman Winkler Institute, Room G04 614, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Bacteriol 188:1310-5. 2006
    ..In conclusion, the four human-specific innate immune modulators SCIN, CHIPS, SAK, and SEA form an IEC that is easily transferred among S. aureus strains by a diverse group of beta-hemolysin-converting bacteriophages...
  47. pmc Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 121:238-48. 2011
    ....
  48. ncbi Community-associated meticillin-resistant Staphylococcus aureus strains as a cause of healthcare-associated infection
    J A Otter
    Directorate of Infection, King s College London and Guy s and St Thomas NHS Foundation Trust, London, UK
    J Hosp Infect 79:189-93. 2011
    ....
  49. pmc Global changes in Staphylococcus aureus gene expression in human blood
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e18617. 2011
    ..These findings, along with a requirement of specific growth conditions for leukotoxin expression, may explain the apparent limited contribution of any single two-component leukotoxin to USA300 immune evasion and virulence...
  50. ncbi Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Rev Microbiol 9:215-22. 2011
    ..Furthermore, we suggest how this can be experimentally confirmed and how it may prompt a change in the current paradigm of S. aureus bacteraemia and identify better treatment options for improved clinical outcomes...
  51. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  52. ncbi The emergence of Staphylococcus aureus ST398
    Tara C Smith
    Department of Epidemiology, Center for Emerging Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    Vector Borne Zoonotic Dis 11:327-39. 2011
    ..We also discuss lingering research questions and implications for controlling spread of this bacterium in an agricultural environment and beyond...
  53. ncbi Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe
    R Kock
    Institute of Hygiene, University Hospital Muenster, Muenster, Germany
    Euro Surveill 15:19688. 2010
    ..Thereby, we aim at identifying unmet needs of surveillance, prevention and control of MRSA in Europe...
  54. ncbi Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary
    Catherine Liu
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, California 94102, USA
    Clin Infect Dis 52:285-92. 2011
    ..Recommendations are provided regarding vancomycin dosing and monitoring, management of infections due to MRSA strains with reduced susceptibility to vancomycin, and vancomycin treatment failures...
  55. pmc Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in midwestern U.S. swine and swine workers
    Tara C Smith
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
    PLoS ONE 4:e4258. 2009
    ..However, no studies to date have investigated carriage of MRSA among swine and swine farmers in the United States (U.S.)...
  56. ncbi Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia
    Christopher P Montgomery
    Department of Pediatrics, Section of Critical Care Medicine, University of Chicago, Illinois 60637, USA
    J Infect Dis 198:561-70. 2008
    ..The explanation for this shift is unclear. We hypothesized that USA300 must be more pathogenic--specifically, that USA300 would have increased virulence when compared with USA400 in an animal model...
  57. ncbi Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine
    J Scott Weese
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G2W1, Canada
    Vet Microbiol 140:418-29. 2010
    ..The relative importance of these staphylococci on different animal species varies, as do the concerns about zoonotic transmission, yet it is clear that both present a challenge to veterinary medicine...
  58. ncbi Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle
    Stefan Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine, Carl Gustav Carus at the Technical University of Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    Vet Microbiol 125:128-40. 2007
    ..The presence of these two strains highlights the possibility of transfers of S. aureus strains between different host species...
  59. pmc Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: a single approach developed by consensus in 10 European laboratories and its application for tracing the spre
    Stephen Murchan
    Laboratory of Hospital Infection, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    J Clin Microbiol 41:1574-85. 2003
    ..This highlights the need for closer international collaboration to monitor the spread of current epidemic strains as well as the emergence of new ones...
  60. ncbi Spa type distribution in Staphylococcus aureus originating from pigs, cattle and poultry
    H Hasman
    Technical University of Denmark, National Food Institute, Bulowsvej 27, 1790 Copenhagen V, Denmark
    Vet Microbiol 141:326-31. 2010
    ..In conclusion, strains of MSSA CC398 were commonly present in pigs but not present at all in the other reservoirs tested...
  61. ncbi Coagulase-negative staphylococcal infections
    Kathie L Rogers
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986280 Nebraska Medical Center, Omaha, NE 68198 6280, USA
    Infect Dis Clin North Am 23:73-98. 2009
    ..This article deals with the clinical syndromes, epidemiology, prevention, and management of infections caused by this unique group of organisms...
  62. ncbi Emergence of methicillin-resistant Staphylococcus aureus (MRSA) in different animal species
    Christiane Cuny
    Robert Koch Institute, Wernigerode Branch, Burgstrasse 37, 38855 Wernigerode, Germany
    Int J Med Microbiol 300:109-17. 2010
    ..Mechanisms of host adaptation and their genomic background are poorly understood so far...
  63. ncbi Prevalence of Staphylococcus aureus nasal colonization in the United States, 2001-2002
    Matthew J Kuehnert
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 193:172-9. 2006
    ..Although methicillin-resistant S. aureus (MRSA) infection has become increasingly reported, population-based S. aureus and MRSA colonization estimates are lacking...
  64. pmc Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease
    Sophie Jarraud
    Faculte de Medecine Laennec, Centre national de référence des toxémies à staphylocoques, 69372 Lyon Cedex 08, France
    Infect Immun 70:631-41. 2002
    ..While these results do not show a direct role of the agr type in the type of human disease caused by S. aureus, the agr group may reflect an ancient evolutionary division of S. aureus in terms of this species' fundamental biology...
  65. ncbi Staphylococcus and biofilms
    Friedrich Götz
    Department of Microbial Genetics, Universitat Tubingen, Waldhäuser Str 70 8, D 72076 Tubingen, Germany
    Mol Microbiol 43:1367-78. 2002
    ..Concepts for the prevention of obstinate polymer-associated infections include the search for new anti-infectives active in biofilms and new biocompatible materials that complicate biofilm formation and the development of vaccines...
  66. pmc Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe
    Marlieke E A de Kraker
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS Med 8:e1001104. 2011
    ....
  67. ncbi Pathogenesis of infections due to coagulase-negative staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Lancet Infect Dis 2:677-85. 2002
    ....
  68. ncbi Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan
    J Immunol 165:5392-6. 2000
    ..aureus is recognized not only by TLR2, but also by other TLR family members except for TLR4...
  69. pmc Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
    Frank R Deleo
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana 59840, USA
    J Clin Invest 119:2464-74. 2009
    ..This Review focuses on progress made toward understanding the success of community-associated MRSA as a human pathogen, with an emphasis on genome-wide approaches and virulence determinants...
  70. ncbi Infection and colonization with methicillin resistant Staphylococcus aureus ST398 versus other MRSA in an area with a high density of pig farms
    M W H Wulf
    PAMM Laboratory for Medical Microbiology, de Run 6250, Veldhoven, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:61-5. 2012
    ..ST398 isolates were more often multi-resistant than isolates of other spa-types. The emergence of MRSA ST398 led to an increase in both MRSA carriers and MRSA infections...
  71. pmc Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications
    Benjamin P Howden
    Department of Infectious Diseases, Austin Health, Victoria, Australia
    Clin Microbiol Rev 23:99-139. 2010
    ..Given the subtleties of vancomycin susceptibility testing against S. aureus, it is imperative that diagnostic laboratories use well-standardized methods and have a framework for detecting reduced vancomycin susceptibility in S. aureus...
  72. pmc Livestock-associated methicillin-resistant Staphylococcus aureus in humans, Europe
    Brigitte A G L van Cleef
    Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 17:502-5. 2011
    ..Livestock-associated MRSA ST398 accounted for only a small proportion of MRSA isolates from humans; most were from the Netherlands, Belgium, Denmark, and Austria...
  73. pmc Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources
    Sem Genini
    Parco Tecnologico Padano CERSA, Via Einstein, 26900 Lodi, Italy
    BMC Genomics 12:225. 2011
    ..aureus. We combined different time points from those studies, testing different responses to mastitis infection: overall (common signature), early stage, late stage, and cattle-specific...
  74. ncbi Staphylococcal infections: mechanisms of biofilm maturation and detachment as critical determinants of pathogenicity
    Michael Otto
    Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892 1881, USA
    Annu Rev Med 64:175-88. 2013
    ....
  75. ncbi Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010
    Michael L Landrum
    Infectious Disease Service, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA
    JAMA 308:50-9. 2012
    ..Rates of hospital-onset methicillin-resistant Staphylococcus aureus (MRSA) infections are reported as decreasing, but recent rates of community-onset S. aureus infections are less known...
  76. pmc Modelling the costs and effects of selective and universal hospital admission screening for methicillin-resistant Staphylococcus aureus
    Gijs Hubben
    Department of Pharmacy, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e14783. 2011
    ..The objective of this study was to determine the long-term costs and health benefits of selective and universal screening for MRSA at hospital admission, using both PCR-based and chromogenic media-based tests in various settings...
  77. ncbi Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
    Kyle J Popovich
    Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 46:787-94. 2008
    ..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
  78. ncbi Livestock-associated Staphylococcus aureus: origin, evolution and public health threat
    J Ross Fitzgerald
    The Roslin Institute and Edinburgh Infectious Diseases, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Edinburgh EH25 NRG, UK
    Trends Microbiol 20:192-8. 2012
    ..aureus clones affecting livestock has been highlighted. Here, I summarise recent developments in this emerging field and suggest questions of importance for future research efforts...
  79. pmc A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus
    Ulrich Nubel
    Robert Koch Institut, Wernigerode, Germany
    PLoS Pathog 6:e1000855. 2010
    ..In addition, comparative genomics indicated complex bacteriophage dynamics...
  80. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
    ..Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA...
  81. pmc Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community
    Keiko Okuma
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    J Clin Microbiol 40:4289-94. 2002
    ..They multiplied much faster than health-care-associated MRSA and were resistant to fewer non-beta-lactam antibiotics. They seem to have been derived from more diverse S. aureus populations than health-care-associated MRSA strains...
  82. pmc Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing
    Michael M Mwangi
    Physics Department, Cornell University, Ithaca, NY 14850, USA
    Proc Natl Acad Sci U S A 104:9451-6. 2007
    ..As costs drop, whole-genome sequencing will become a useful tool in elucidating complex pathways of in vivo evolution in bacterial pathogens...
  83. ncbi Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers
    T Khanna
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Vet Microbiol 128:298-303. 2008
    ..This study demonstrates that MRSA is common in pigs in Ontario, Canada, and provides further support to concerns about transmission of MRSA between pigs and humans...
  84. pmc Characterization of nasal and blood culture isolates of methicillin-resistant Staphylococcus aureus from patients in United States Hospitals
    Fred C Tenover
    Cepheid, Sunnyvale, California, USA
    Antimicrob Agents Chemother 56:1324-30. 2012
    ..S. hospitalized patients, USA100 isolates of multiple spa types, while still common in the nares, have been replaced by USA300 isolates as the predominant MRSA strain type in positive blood cultures...
  85. ncbi Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo
    Lloyd S Miller
    Division of Dermatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 179:6933-42. 2007
    ..aureus in vivo...
  86. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
    ..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases...
  87. ncbi Preventing surgical-site infections in nasal carriers of Staphylococcus aureus
    Lonneke G M Bode
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 362:9-17. 2010
    ..Nasal carriers of Staphylococcus aureus are at increased risk for health care-associated infections with this organism. Decolonization of nasal and extranasal sites on hospital admission may reduce this risk...
  88. pmc Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection
    Lorena Tuchscherr
    Institute of Medical Microbiology, University Hospital of Munster, Munster, Germany
    EMBO Mol Med 3:129-41. 2011
    ..Our findings demonstrate that bacterial phenotype switching is an integral part of the infection process that enables the bacteria to hide inside host cells, which can be a reservoir for chronic and therapy-refractive infections...
  89. ncbi Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections
    Rajiv Jain
    Patient Care Services, Veterans Affairs Central Office, and the VA Pittsburgh Healthcare System, Pittsburgh, USA
    N Engl J Med 364:1419-30. 2011
    ..Health care-associated infections with methicillin-resistant Staphylococcus aureus (MRSA) have been an increasing concern in Veterans Affairs (VA) hospitals...
  90. pmc Repair of global regulators in Staphylococcus aureus 8325 and comparative analysis with other clinical isolates
    Silvia Herbert
    Microbial Genetics, University of Tubingen, Tubingen, Germany
    Infect Immun 78:2877-89. 2010
    ..If this mutation were repaired, Newman would be considerably improved as a model strain...
  91. pmc Determining confidence intervals when measuring genetic diversity and the discriminatory abilities of typing methods for microorganisms
    H Grundmann
    Division of Microbiology and Infectious Diseases, University Hospital Nottingham, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Clin Microbiol 39:4190-2. 2001
    ..This approach facilitates the comparison of the genetic population structure of microorganisms isolated from different environments and improves the objective assessment of the discriminatory power of typing techniques...
  92. ncbi Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'
    Catarina Milheiriço
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    J Antimicrob Chemother 60:42-8. 2007
    ..To develop and validate a new multiplex PCR strategy for subtyping SCCmec type IV methicillin-resistant Staphylococcus aureus (MRSA) strains-SCCmec IV multiplex PCR...
  93. pmc Two distinct clones of methicillin-resistant Staphylococcus aureus (MRSA) with the same USA300 pulsed-field gel electrophoresis profile: a potential pitfall for identification of USA300 community-associated MRSA
    Anders Rhod Larsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, B 47, Artillerivej 5, DK 2300 Copenhagen
    J Clin Microbiol 47:3765-8. 2009
    ..The second (ST8-IVa, t024, and PVL negative) had different molecular characteristics and epidemiology, suggesting independent evolution. We recommend spa typing and/or PCR to discriminate between the two clones...
  94. pmc Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Innate Immun 2:560-75. 2010
    ..aureus pore-forming toxins. We propose that the ability of CA-MRSA strains to induce programmed necrosis of neutrophils is a component of enhanced virulence...
  95. ncbi Are host genetics the predominant determinant of persistent nasal Staphylococcus aureus carriage in humans?
    Raymond Ruimy
    EA3964 Université Paris Diderot and Centre National de Référence, Résistance bactérienne dans les flores commensales, Hopital Bichat Claude Bernard, AP HP, Paris, France
    J Infect Dis 202:924-34. 2010
    ..Therefore, we concomitantly assessed the epidemiological, microbiological, and human-genetic carriage-related factors in a nearly closed population...
  96. ncbi Staphylococcus aureus: Staphylokinase
    Maria I Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, SE 41346 Göteborg, Sweden
    Int J Biochem Cell Biol 38:504-9. 2006
    ..Our observations indicate that staphylokinase favours symbiosis of staphylococci with the host that makes it an important colonization factor...
  97. pmc Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus
    Sarah K Highlander
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    BMC Microbiol 7:99. 2007
    ..Epidemiological studies suggest that USA300 is more virulent than other CA-MRSA. The genetic determinants that render virulence and dominance to USA300 remain unclear...
  98. ncbi Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
    J D Pollock
    Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    Nat Genet 9:202-9. 1995
    ..This animal model should aid in developing new treatments for CGD and in evaluating the role of phagocyte-derived oxidants in inflammation...
  99. ncbi Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Europe
    Jonathan A Otter
    Department of Infection, King s College London and St Thomas Hospital, London, UK
    Lancet Infect Dis 10:227-39. 2010
    ..An understanding of the epidemiology of community-associated MRSA is essential to guide new control initiatives to prevent these organisms from becoming endemic in Europe...
  100. pmc Clonal distribution of superantigen genes in clinical Staphylococcus aureus isolates
    S Holtfreter
    Institut fur Immunologie, Universitat Greifswald, Greifswald, Germany
    J Clin Microbiol 45:2669-80. 2007
    ..In summary, we show here that the simultaneous assessment of virulence gene profiles and the genetic background increases the discriminatory power of genetic investigations into the mechanisms of S. aureus pathogenesis...
  101. pmc Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 46:1492-502. 2002
    ..These findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through the development of vancomycin tolerance...

Research Grants62

  1. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..4.6 % of individuals admitted into American hospitals suffer staphylococcal infections, claiming an aggregate mortality of about 100,000 lives this year...
  2. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..Despite intense efforts, the molecular mechanism of staphylococcal infections is incompletely understood, but it seemingly involves a large number of virulence factors such as ..
  3. Prevention and therapy of Staphylococcus aureus infections
    Olaf Schneewind; Fiscal Year: 2010
    ..will generate immune therapeutics for the treatment of MRSA infections and vaccines to globally prevent staphylococcal infections. This ARRA proposal represents a one-time investment into a unique knowledge gap and a technological ..
  4. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    ..is based on four fundamental discoveries: 1) Hla is required for the pathogenesis of pneumonia and other staphylococcal infections, and preventative and therapeutic strategies that antagonize toxin action afford protection against ..
  5. Type I interferon-induced protection from staphylococcal pore-forming toxins
    TIMUR OLEGOVICH YAROVINSKY; Fiscal Year: 2010
    ..is to identify novel approaches that could be used to decrease severity and improve the outcome of staphylococcal infections. Staphylococcal pore-forming toxins, such as alpha-toxin and Panton-Valentine leukocidin, contribute to ..
  6. Hemostatic-antibiotic Combination for Prevention of MRSA Surgical Site Infections
    Timothy C Fisher; Fiscal Year: 2010
    ..Over 50% of all SWI are Staphylococcal infections, the majority of which are caused by drug-resistant variants such as methicillin-resistant S...
  7. Citric acid cycle regulation of exopolysaccharide synthesis in staphylococci
    GREG ALAN SOMERVILLE; Fiscal Year: 2013
    ..Exopolysaccharides are important mediators of staphylococcal infections;specifically, polysaccharide intercellular adhesin (PIA) enhances biofilm formation and immune evasion, ..
  8. Virulence Determinants in Staphylococcus Bacteremia
    Steven R Gill; Fiscal Year: 2012
    ..Knowledge acquired from this study could potentially be used to develop novel and possibly preventive therapies to eradicate complicated staphylococcal infections.
  9. Role of the Staphylococcus aureus SaeR/S Regulatory System in Neutrophil Evasion
    Jovanka M Voyich; Fiscal Year: 2013
    ..aureus infection. This knowledge is predicted to have direct application for novel prevention and treatment strategies for staphylococcal infections.
  10. A longitudinal Study of CA-MRSA Nasal Colonization in College Sports Participants
    Clarence Buddy Creech; Fiscal Year: 2010
    ..Treatment of staphylococcal infections has become more challenging due to the emergence of community-associated methicillin-resistant S...
  11. Adaptation of Staphylococcus aureus to Mn-limitation imposed by the host
    THOMAS EVERETT KEHL-FIE; Fiscal Year: 2013
    ..increasing antibiotic resistance results in the high levels of morbidity and mortality associated with staphylococcal infections. A powerful strategy utilized by vertebrates to combat bacterial pathogens is the sequestration of ..
  12. Mechanistic Studies Of The Mode Of Action Of The Staphylococcus aureus LukAB Cyto
    Victor J Torres; Fiscal Year: 2013
    ..clearance by the host via targeted killing of neutrophils;innate immune cells integral to the control of Staphylococcal infections. Thus, the long-term goal of this research program is to understand the mechanism employed by S...
  13. Staphylococcal biofilm and disease
    Kenneth W Bayles; Fiscal Year: 2013
    ..of the staphylococci including: biofilm development, gene regulation, physiology, and the immunology of staphylococcal infections. The hypothesis to be tested by this team in this application is that S...
  14. Defining the Impact of Human Hemoglobin Variations on Staphylococcal Pathogenesis
    Allison J Farrand; Fiscal Year: 2013
    ..b>Staphylococcal infections occur in both hospital settings and in the community, and concern over the spread of these infections is ..
  15. A nanotherapeutic approach to combat staphylococcal biofilm-associated infection
    Mark S Smeltzer; Fiscal Year: 2011
    ..The latter is evident in the observation that the successful resolution of biofilm-associated staphylococcal infections often requires surgical intervention to debride infected tissues and/or remove infected implants even ..
  16. Functional Analysis of Staphylococcus aureus LukAB Cytotoxin.
    Victor J Torres; Fiscal Year: 2011
    ..and kills host phagocytes, important cells of the immune system that play a major role in controlling staphylococcal infections. The aims of this application are to: (i) identify and characterize host molecules responsible for LukAB ..
  17. Significance of four methionine sulfoxide reductases in Staphylococcus aureus
    Vineet Kumar Singh; Fiscal Year: 2010
    ..aureus, and should suggest new therapeutic strategies for the control of staphylococcal infections.
  18. Mentoring Clinical and Translational Patient-Oriented Research in Staphylococci
    Vance G Fowler; Fiscal Year: 2013
    ..catheter-related staphylococcal bacteremia, and two other projects employing large clinical databases of staphylococcal infections. Specific Aim 2, mentoring translational patient-oriented research in staphylococci, will be ..
  19. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..b>Staphylococcal infections occur most frequently when mucosal barriers are breached, following insertion of a foreign body, or in ..
  20. ESAT-6 Secretion in Staphylococcus Aureus
    Dominique M Missiakas; Fiscal Year: 2013
    ..The Ess pathway is required for the pathogenesis of staphylococcal infections, as esxB mutants are unable to form abscesses or persist in host tissues, whereas mutants that impact ..
  21. Murine Model of Job's syndrome
    John P Manis; Fiscal Year: 2012
    ..HIES) is a primary immunodeficiency disorder generally characterized by chronic eczema, recurrent staphylococcal infections, and increased serum IgE levels...
  22. STAPHYLOCOCCUS AUREUS: CAPSULAR ANTIGENS AND IMMUNITY
    Jean Lee; Fiscal Year: 1993
    ..aureus capsule play a role in immunity to staphylococcal infections and to expand our fundamental knowledge concerning the biology and immunochemistry of the staphylococcal ..
  23. Capsule regulatory network in S. aureus pathogenesis
    Chia Y Lee; Fiscal Year: 2013
    ..The new knowledge gained from these studies will provide a firm basis for developing novel methods for controlling staphylococcal infections.
  24. PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 2003
    ..of penicillins and beta-lactam antibiotics is the real problem, as these are drug of choice to treat staphylococcal infections. The objective of this research is to further knowledge of mechanisms of methicillin resistance...
  25. SKIN-REACTIVE MICROCOCCAL EXOPROTEINS--MOLECULAR BIOLOGY
    KIRK WUEPPER; Fiscal Year: 1990
    ..This was based on localized staphylococcal infections, phage typing of staphylococci and histologic findings...
  26. Regulation of Virulence by luxS in Staphylococcus aureus
    Mohamed Elasri; Fiscal Year: 2005
    ..Our goal is to fill this gap as a prerequisite to developing therapeutic protocols for treatment of staphylococcal infections. In the proposed research, the hypothesis is that luxS system regulates the expression of virulence ..
  27. Nanocarrier with metal bridge for affinity based delivery of metal binding peptid
    Elijah Bolotin; Fiscal Year: 2009
    ..lysostaphin in an optimal infection site-directed delivery system for the treatment of invasive staphylococcal infections. Public Health Relevance: The available therapies for antibiotic resistant S...
  28. GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASES
    Henry Chambers; Fiscal Year: 1999
    ..clinical researchers and scientists in industry who are involved in the study of staphylococci, staphylococcal infections and virulence of gram-positive cocci for humans...
  29. Structure of Beta-lactam resistance regulators
    MARTIN SAFO; Fiscal Year: 2007
    ..However, beta-lactam antibiotics, the most effective therapy for treating staphylococcal infections, are becoming less effective as resistance to them among staphylococci increases...
  30. VIRULENCE AND IMMUNITY TO STAPHYLOCOCCI
    Gerald Pier; Fiscal Year: 2000
    ..above mentioned studies will provide new and useful information regarding pathogenesis and immunity of staphylococcal infections, because it has not previously been appreciated that S...
  31. Quorum sensing and Staphylococcus aureus pathogenesis
    Naomi Balaban; Fiscal Year: 2005
    ..understand how virulence is regulated in Staphylococcus aureus and to further develop immunotherapy to staphylococcal infections. S...
  32. REGULATIONS OF IRON ACQUISITATION BY S AUREUS
    RADHESHYAM JAYASWAL; Fiscal Year: 2000
    ..The results of this study may identify novel targets that interfere with iron uptake and its regulation and may lead to alternative therapies for staphylococcal infections.
  33. STAPHYLOCOCCAL TOLERANCE AND GRANULOCYTIC FUNCTION
    GARY BEST; Fiscal Year: 1980
    ..from normal granulocytes, we will then include white cells from patients with recurrent, superficial staphylococcal infections and with acute staphylococcal infections to ascertain which of several potentially important ..
  34. ACTIVE & PASSIVE IMMUNIZATION FOR STAPHYLOCOCCAL DISEASE
    Subramonia Pillai; Fiscal Year: 2000
    ..and concurrent development of these three areas will provide multiple leads targeted to protect against staphylococcal infections in immunocompromised individuals, in patients undergoing elective surgery...
  35. 2007 Staphylococcal Diseases Gordon Conference
    Kenneth Bayles; Fiscal Year: 2007
    ..from academia, industry, and government who share a[unreadable] common interest in staphylococci and staphylococcal infections. It is well known for[unreadable] fostering an environment that encourages scientific collaborations, ..
  36. IRON ACQUISITION BY STAPHYLOCOCCI
    Loreen Herwaldt; Fiscal Year: 1993
    ..will enable the Principal Investigator (PI) to address critical questions regarding the pathogenesis of staphylococcal infections. The data will give important insights into the differences between infections caused by S...
  37. PEGylated Lysostaphin for Staphylococcal Infections
    John Kokai Kun; Fiscal Year: 2004
    ..aureus infections (as a nasal cream) and in treating topical and systemic S. aureus infections, including S. aureus endocarditis. ..
  38. CLINICAL DEVELOPMENT OF SA-IGIV FOR S AUREUS INFECTIONS
    Joseph Patti; Fiscal Year: 2000
    ..In the past, powerful antibiotic drugs have provided effective treatments for staphylococcal infections. However, each antibiotic introduced has been met by the emergence of drug resistant staphylococcal ..
  39. 2009 Staphylococcal Diseases Gordon Conference
    Kenneth Bayles; Fiscal Year: 2009
    ..investigators from academia, industry, and government who share a common interest in staphylococci and staphylococcal infections. It is well known for fostering an environment that encourages scientific collaborations, lively and ..
  40. DYNAMIC PLATELET - STAPHYLOCOCCAL INTERACTIONS
    Julia Ross; Fiscal Year: 2004
    ..of platelet activation, blood components, blood flow, and bacteria in the development of blood-born staphylococcal infections. A long-term goal of this work is to investigate the interrelationship between thrombogenesis and ..
  41. Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Kazue Takahashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Novel antibacterial agents for treatment of Tularemia
    Nachum Kaplan; Fiscal Year: 2004
    ..Phase II clinical trials are proposed in Years 4 and 5, as a narrow spectrum agent for the treatment of Staphylococcal infections. This funding will assure rapid progress of this new class of antibacterial agent through the last ..
  43. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  44. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  45. THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTS
    Loren Miller; Fiscal Year: 2004
    ....
  46. UNDERSTANDING THE PATHOGENESIS OF STAPHYLOCOCCUS AUREUS
    Vance Fowler; Fiscal Year: 2003
    ..Accomplishing the aims of this proposal will contribute to improved clinical management of patients with S. aureus bacteremia, and will add to the understanding of S. aureus virulence factors. ..
  47. METALLO BETA LACTAMASE FROM X MALTOPHILIA
    Michael Crowder; Fiscal Year: 2002
    ....
  48. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  49. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  50. Zn(II) metallochaperones in E. coli
    Michael Crowder; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Environmental Effects on Lung Function in Cystic Fibrosis Patients
    Christopher Goss; Fiscal Year: 2008
    ..Our proposal will also enhance our understanding of lung growth in CF and represents the initial phase of a program to understand environmental effects on CF lung disease. [unreadable] [unreadable] [unreadable]..
  52. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
  53. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  54. Characterization of innate immune response stimulation by Sin Nombre virus
    Pamela Hall; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Novel Targets for Treatment of Pseudomonas aeruginosa
    Philip Lister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  56. Spread of Community-Acquired MRSA Among Household Contacts
    Robert S Daum; Fiscal Year: 2010
    ....
  57. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  58. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  59. Early Diagnosis of Growth Disorders Uing MR Imaging
    Diego Jaramillo; Fiscal Year: 2004
    ....
  60. MRSA Colonization and Control in the Cook County Jail - R01
    Robert Daum; Fiscal Year: 2008
    ..We hope that the Cook County jail will become a model jail for the control of MRSA and other resistant bacteria. [unreadable] [unreadable] [unreadable]..