q fever

Summary

Summary: An acute infectious disease caused by COXIELLA BURNETII. It is characterized by a sudden onset of FEVER; HEADACHE; malaise; and weakness. In humans, it is commonly contracted by inhalation of infected dusts derived from infected domestic animals (ANIMALS, DOMESTIC).

Top Publications

  1. ncbi Natural history and pathophysiology of Q fever
    D Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Lancet Infect Dis 5:219-26. 2005
  2. ncbi Q Fever
    Emmanouil Angelakis
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Université de Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Vet Microbiol 140:297-309. 2010
  3. pmc Host cell-free growth of the Q fever bacterium Coxiella burnetii
    Anders Omsland
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 106:4430-4. 2009
  4. pmc Coxiella burnetii in humans and ticks in rural Senegal
    Oleg Mediannikov
    URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
    PLoS Negl Trop Dis 4:e654. 2010
  5. pmc Coxiella burnetii genotyping
    Olga Glazunova
    Unite des Rickettsies, Faculte de Medecine, CNRS UMR 6020, IFR48, Marseille, France
    Emerg Infect Dis 11:1211-7. 2005
  6. pmc The health status of Q-fever patients after long-term follow-up
    Gabriella Morroy
    Department of Infectious Disease Control, Municipal Health Service Hart voor Brabant, s Hertogenbosch, The Netherlands
    BMC Infect Dis 11:97. 2011
  7. ncbi The 2007–2010 Q fever epidemic in The Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming
    Frederika Dijkstra
    National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 64:3-12. 2012
  8. pmc Genome-wide profiling of humoral immune response to Coxiella burnetii infection by protein microarray
    ADAM VIGIL
    Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA
    Proteomics 10:2259-69. 2010
  9. ncbi Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome
    E Botelho-Nevers
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 5, France
    Eur J Clin Microbiol Infect Dis 26:635-40. 2007
  10. pmc Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands
    Hendrik I J Roest
    Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands
    Emerg Infect Dis 17:668-75. 2011

Detail Information

Publications346 found, 100 shown here

  1. ncbi Natural history and pathophysiology of Q fever
    D Raoult
    Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Lancet Infect Dis 5:219-26. 2005
    b>Q fever is a zoonosis caused by Coxiella burnetii. Infection with C burnetii can be acute or chronic, and exhibits a wide spectrum of clinical manifestations...
  2. ncbi Q Fever
    Emmanouil Angelakis
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Université de Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Vet Microbiol 140:297-309. 2010
    b>Q fever is a zoonotic disease caused by the ubiquitous pathogen Coxiella burnetii responsible for acute and chronic clinical manifestations...
  3. pmc Host cell-free growth of the Q fever bacterium Coxiella burnetii
    Anders Omsland
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 106:4430-4. 2009
    ..burnetii will facilitate studies of the organism's pathogenesis and genetics and aid development of Q fever preventatives such as an effective subunit vaccine...
  4. pmc Coxiella burnetii in humans and ticks in rural Senegal
    Oleg Mediannikov
    URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
    PLoS Negl Trop Dis 4:e654. 2010
    b>Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts.
  5. pmc Coxiella burnetii genotyping
    Olga Glazunova
    Unite des Rickettsies, Faculte de Medecine, CNRS UMR 6020, IFR48, Marseille, France
    Emerg Infect Dis 11:1211-7. 2005
    ..Phylogenic analysis showed 3 major clusters. MST allows easy comparison and exchange of results obtained in different laboratories and could be a useful tool for identifying bacterial strains...
  6. pmc The health status of Q-fever patients after long-term follow-up
    Gabriella Morroy
    Department of Infectious Disease Control, Municipal Health Service Hart voor Brabant, s Hertogenbosch, The Netherlands
    BMC Infect Dis 11:97. 2011
    ..The aim of this study was to qualify and quantify the health status of Q-fever patients after long-term follow-up...
  7. ncbi The 2007–2010 Q fever epidemic in The Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming
    Frederika Dijkstra
    National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 64:3-12. 2012
    We describe the Q fever epidemic in the Netherlands with emphasis on the epidemiological characteristics of acute Q fever patients and the association with veterinary factors...
  8. pmc Genome-wide profiling of humoral immune response to Coxiella burnetii infection by protein microarray
    ADAM VIGIL
    Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA 92697, USA
    Proteomics 10:2259-69. 2010
    ..Furthermore, we report here the identification of several new diagnostic antigens and potential subunit vaccine candidates for the highly infectious category B alphaproteobacteria, C. burnetii...
  9. ncbi Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome
    E Botelho-Nevers
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 5, France
    Eur J Clin Microbiol Infect Dis 26:635-40. 2007
    b>Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis...
  10. pmc Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands
    Hendrik I J Roest
    Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands
    Emerg Infect Dis 17:668-75. 2011
    b>Q fever is a zoonosis caused by the bacterium Coxiella burnetii...
  11. pmc T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice
    Masako Andoh
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 75:3245-55. 2007
    Coxiella burnetii, the etiological agent of Q fever, has two phase variants. Phase I has a complete lipopolysaccharide (LPS), is highly virulent, and causes Q fever in humans and pathology in experimental animals...
  12. ncbi Q fever 1985-1998. Clinical and epidemiologic features of 1,383 infections
    D Raoult
    Unite des Rickettsies, Universite de la Mediterranee, Marseille, France
    Medicine (Baltimore) 79:109-23. 2000
    ..clinical features and the epidemiologic findings of 1,383 patients hospitalized in France for acute or chronic Q fever, we conducted a retrospective analysis based on 74,702 sera tested in our diagnostic center, National Reference ..
  13. pmc Molecular characterization of Coxiella burnetii isolates by infrequent restriction site-PCR and MLVA typing
    Nathalie Arricau-Bouvery
    INRA, Pathologie Infectieuse et Immunologie, 37380 Nouzilly, France
    BMC Microbiol 6:38. 2006
    Coxiella burnetii, the causative agent of Q fever, has a wide host range. Few epidemiological tools are available, and they are often expensive or not easily standardized across laboratories. In this work, C...
  14. ncbi Is Q fever an emerging or re-emerging zoonosis?
    Nathalie Arricau-Bouvery
    Pathologie Infectieuse et Immunologie, INRA, Centre de Tours Nouzilly, 37380 Nouzilly, France
    Vet Res 36:327-49. 2005
    b>Q fever is a zoonotic disease considered as emerging or re-emerging in many countries. It is caused by Coxiella burnetii, a bacterium developing spore-like forms that are highly resistant to the environment...
  15. pmc Wind in November, Q fever in December
    Hervé Tissot-Dupont
    Unite des Rickettsies, CNRS, Faculte de Medecine, Marseille, France
    Emerg Infect Dis 10:1264-9. 2004
    b>Q fever, a worldwide zoonosis caused by Coxiella burnetii, can be transmitted from animal reservoirs to humans by the inhalation of infected aerosols...
  16. pmc Genotypic diversity of Coxiella burnetii in the 2007-2010 Q fever outbreak episodes in The Netherlands
    Jeroen J H C Tilburg
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    J Clin Microbiol 50:1076-8. 2012
    The genotypic diversity of Coxiella burnetii in clinical samples obtained from the Dutch Q fever outbreak episodes of 2007-2010 was determined by using a 6-locus variable-number tandem repeat analysis panel...
  17. pmc Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, The Netherlands
    Lenny Hogerwerf
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Emerg Infect Dis 17:379-86. 2011
    Recently, the number of human Q fever cases in the Netherlands increased dramatically. In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii...
  18. ncbi Identification and cloning potentially protective antigens of Coxiella burnetii using sera from mice experimentally infected with Nine Mile phase I
    G Q Zhang
    Department of Medical Microbiology and Immunology, Texas A M University System Health Science Center, College Station, Texas 77843 1114, USA
    Ann N Y Acad Sci 990:510-20. 2003
    Coxiella burnetii is an obligate intracellular bacterium that causes acute Q fever and occasional chronic infections in humans. To determine the immunodominant antigens during infection with C...
  19. ncbi Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach
    Z Sekeyova
    Faculte de Medecine, Universite de la Mediterranee, URMITE 6236 IRD, IFR 48, 27 Boulevard Jean Moulin, 05 13385 Marseille Cedex, France
    Eur J Clin Microbiol Infect Dis 28:287-95. 2009
    b>Q fever is a worldwide zoonosis caused by Coxiella burnetii bacterium. Two clinical forms are present: acute Q fever and chronic disease, including endocarditis...
  20. ncbi Experimental Coxiella burnetii infection in pregnant goats: excretion routes
    Nathalie Arricau Bouvery
    Pathologie Infectieuse et Immunologie, INRA, Tours Nouzilly, 37380 Nouzilly, France
    Vet Res 34:423-33. 2003
    b>Q fever is a widespread zoonosis caused by Coxiella burnetii. Infected animals, shedding bacteria by different routes, constitute contamination sources for humans and the environment...
  21. pmc The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak
    Barbara Schimmer
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, A van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Infect Dis 10:69. 2010
    ..A generic geographic information system (GIS) was used to develop a method for source detection in the still evolving major epidemic of Q-fever in the Netherlands...
  22. ncbi Role of sex, age, previous valve lesion, and pregnancy in the clinical expression and outcome of Q fever after a large outbreak
    Hervé Tissot-Dupont
    Unite des Rickettsies, Unite Mixte de Recherche 6020, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 44:232-7. 2007
    b>Q fever is a zoonosis caused by Coxiella burnetii...
  23. ncbi Q fever
    Sally J Cutler
    University of East London, School of Health and Bioscience, Romford Road, Stratford, London, UK
    J Infect 54:313-8. 2007
    An outbreak of Q fever occurred in Scotland during this summer and was reported in news headlines. Despite these newsworthy headlines, Q fever remains poorly understood...
  24. ncbi Establishment of a genotyping scheme for Coxiella burnetii
    Sanela Svraka
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Microbiol Lett 254:268-74. 2006
    Coxiella burnetii is the causative agent of Q fever. The bacterium is highly infectious and is classified as a category B biological weapon...
  25. ncbi Brucellosis and Q-fever seroprevalences of nomadic pastoralists and their livestock in Chad
    E Schelling
    Swiss Tropical Institute, Socinstrasse 57, P O Box, CH 4002 Basel, Switzerland
    Prev Vet Med 61:279-93. 2003
    ....
  26. ncbi Q fever (coxiellosis): epidemiology and pathogenesis
    Zerai Woldehiwet
    Department of Veterinary Pathology, University of Liverpool, Veterinary Teaching Hospital, Leahurst, Neston, Wirral CH64 7TE, UK
    Res Vet Sci 77:93-100. 2004
    b>Q fever is a widespread zoonosis caused by the Gram-negative bacterium Coxiella burnetii. Aborting domestic ruminants are the main sources of human infection but the reservoir of infection is extremely wide...
  27. pmc Single-nucleotide-polymorphism genotyping of Coxiella burnetii during a Q fever outbreak in The Netherlands
    Cornelis J J Huijsmans
    Laboratory of Molecular Diagnostics, Jeroen Bosch Hospital, Nieuwstraat 34, 5211 NL s Hertogenbosch, Netherlands
    Appl Environ Microbiol 77:2051-7. 2011
    Coxiella burnetii is the etiological agent of Q fever. Currently, the Netherlands is facing the largest Q fever epidemic ever, with almost 4,000 notified human cases...
  28. pmc Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray
    Paul A Beare
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    Clin Vaccine Immunol 15:1771-9. 2008
    b>Q fever is a widespread zoonosis caused by Coxiella burnetii. Diagnosis of Q fever is usually based on serological testing of patient serum...
  29. ncbi Q Fever during pregnancy: a cause of poor fetal and maternal outcome
    Xavier Carcopino
    Service de Gynecologie Obstetrique, Hopital Nord, Chemin des Bourrely, 13915 cedex 20, Marseille, France
    Ann N Y Acad Sci 1166:79-89. 2009
    b>Q fever is a worldwide zoonosis caused by Coxiella burnetii. Q fever may be present as an acute or a chronic infection and can be reactivated during subsequent pregnancies...
  30. pmc Real-time PCR with serum samples is indispensable for early diagnosis of acute Q fever
    Peter M Schneeberger
    Jeroen Bosch Hospital, Department of Medical Microbiology and Infection Control, P O Box 90153, 5200 ME s Hertogenbosch, The Netherlands
    Clin Vaccine Immunol 17:286-90. 2010
    The world's largest Q fever outbreak is ongoing in The Netherlands with around 3,000 confirmed cases since the first half of 2007. Increased awareness has resulted in early referral of patients for diagnostics...
  31. pmc Q fever in young children, Ghana
    Robin Kobbe
    Emerg Infect Dis 14:344-6. 2008
  32. pmc Acute Q fever and scrub typhus, southern Taiwan
    Chung Hsu Lai
    E Da Hospital and I Shou University, Kaoh siung City, Taiwan
    Emerg Infect Dis 15:1659-61. 2009
    Acute Q fever and scrub typhus are zoonoses endemic to southern Taiwan. Among the 137 patients with acute Q fever (89, 65.0%) or scrub typhus (43, 31.4%), we identified 5 patients (3...
  33. pmc Prevalence of Coxiella burnetii antibodies in Danish dairy herds
    Jens F Agger
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 8, Frederiksberg, DK 1870 C, Denmark
    Acta Vet Scand 52:5. 2010
    ..The result supports the hypothesis of an increase in the prevalence of positive dairy herds compared to previous years...
  34. ncbi Effect of sex on Coxiella burnetii infection: protective role of 17beta-estradiol
    Marc Leone
    Unite des Rickettsies, Universite de la Mediterranee, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 6020, Faculte de Medecine, Marseille, France
    J Infect Dis 189:339-45. 2004
    b>Q fever is a zoonosis caused by Coxiella burnetii and recently has been recognized as a potential agent of bioterrorism. In Q fever, men are symptomatic more often than women, despite equal seroprevalence...
  35. ncbi Chronic Q fever: different serological results in three countries--results of a follow-up study 6 years after a point source outbreak
    Brendan Healy
    Public Health Wales, Microbiology Department, UHW Heath Park, Cardiff, Wales, United Kingdom
    Clin Infect Dis 52:1013-9. 2011
    Acute and chronic Q fever/Coxiella burnetii infection is diagnosed principally by serology. The management of patients who have serological evidence of chronic Q fever but no other manifestation of chronic infection is challenging.
  36. ncbi Identification of risk factors of Coxiella burnetii (Q fever) infection in veterinary-associated populations in southern Taiwan
    C C Chang
    Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan
    Zoonoses Public Health 57:e95-101. 2010
    The first case of Q fever in Taiwan was reported in 1993. The disease is considered to be emerging in Taiwan, but the route of transmission has remained unclear...
  37. ncbi Detection of Coxiella burnetii, the agent of Q fever, in oviducts and uterine flushing media and in genital tract tissues of the non pregnant goat
    Ashraf Alsaleh
    LUNAM University, ONIRIS, Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Department of Research into the Health Risk and Biotechnology of Reproduction, Nantes, France
    Comp Immunol Microbiol Infect Dis 34:355-60. 2011
    ..The infection of genital tract flushing media and tissues is a risk factor for the transmission of C. burnetii from donor to recipient during embryo transfer or to the embryo and fetus when gestation is pursued to term...
  38. ncbi Follow-up of 686 patients with acute Q fever and detection of chronic infection
    Wim van der Hoek
    Epidemiology and Surveillance Unit, Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Clin Infect Dis 52:1431-6. 2011
    Recent outbreaks in the Netherlands allowed for laboratory follow-up of a large series of patients with acute Q fever and for evaluation of test algorithms to detect chronic Q fever, a condition with considerable morbidity and mortality.
  39. pmc Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania
    Malavika Prabhu
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
    Clin Infect Dis 53:e8-15. 2011
    The importance of Q fever, spotted fever group rickettsiosis (SFGR), and typhus group rickettsiosis (TGR) as causes of febrile illness in sub-Saharan Africa is unknown; the putative role of Q fever as a human immunodeficiency virus (HIV) ..
  40. pmc Molecular method for the characterization of Coxiella burnetii from clinical and environmental samples: variability of genotypes in Spain
    Isabel Jado
    Laboratorio de Espiroquetas y Patógenos Especiales, Department of Bacteriology, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra, de Pozuelo km 2, 6, Majadahonda, Madrid, 28220, Spain
    BMC Microbiol 12:91. 2012
    ..burnetii genotypes...
  41. pmc Risk factors of Coxiella burnetii (Q fever) seropositivity in veterinary medicine students
    Myrna M T de Rooij
    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht, The Netherlands
    PLoS ONE 7:e32108. 2012
    b>Q fever is an occupational risk for veterinarians, however little is known about the risk for veterinary medicine students...
  42. ncbi Q fever in the Netherlands from 2007 to 2010
    C E Delsing
    Department of Internal Medicine Radboud Expertise Centre for Q fever, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 68:382-7. 2010
    Since 2007, the Netherlands is faced with the largest outbreak of Q fever ever reported. In the last four years, over 4000 cases have been reported...
  43. pmc Identification and characterization of an immunodominant 28-kilodalton Coxiella burnetii outer membrane protein specific to isolates associated with acute disease
    Guoquan Zhang
    Department of Medical Microbiology and Immunology, 407 Reynolds Medical Building, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 73:1561-7. 2005
    Coxiella burnetii causes acute Q fever in humans and occasional chronic infections that typically manifest as endocarditis or hepatitis...
  44. ncbi [Abortion and stillbirth among dairy goats as a consequence of Coxiella burnetii]
    W Wouda
    GD, Postbus 9, 7400 AA Deventer
    Tijdschr Diergeneeskd 132:908-11. 2007
    The clinical signs and pathological findings of clinical Q fever in dairy goats in the Netherlands are described. The disease is characterized by endemic or epidemic abortion in late pregnancy, stillbirth, or the birth of weak kids...
  45. ncbi Natural history of Q fever in goats
    Todd Hatchette
    The Department of Medicine, Dalhousie University, Halifax, Nova Scotia
    Vector Borne Zoonotic Dis 3:11-5. 2003
    During the spring of 1999, an outbreak of Q fever resulted in 30 abortions among 174 (17%) goats in a caprine cooperative in Newfoundland...
  46. pmc Clinical and pathologic changes in a guinea pig aerosol challenge model of acute Q fever
    K E Russell-Lodrigue
    Department of Veterinary Pathobiology, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 74:6085-91. 2006
    Acute Q fever is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii and can manifest as a flu-like illness, pneumonia, or hepatitis...
  47. pmc Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein
    Anja Lührmann
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 107:18997-9001. 2010
    ..Thus, emergence of an effector protein that interferes with a proapoptotic signaling pathway directed against intracellular bacteria correlates with adaptation of a pathogen to mammalian hosts...
  48. ncbi Prevention of Coxiella burnetii shedding in infected dairy herds using a phase I C. burnetii inactivated vaccine
    Raphaël Guatteo
    Ecole Nationale Veterinaire de Nantes, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, F 44307 Nantes, France
    Vaccine 26:4320-8. 2008
    ..e. at least the heifers. The vaccination of the dairy cows should be performed when the within-herd seroprevalence is low, i.e. in herds where the infection has not spread widely yet...
  49. ncbi Q fever: a biological weapon in your backyard
    Miguel G Madariaga
    Division of Infectious Disease, Cook County Hospital, Chicago and the Section of Infectious Diseases, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Lancet Infect Dis 3:709-21. 2003
    Coxiella burnetii, which causes Q fever, is a highly infectious agent that is widespread among livestock around the world. Although the culture process for coxiella is laborious, large amounts of infectious material can be produced...
  50. ncbi Risks factors and prevention of Q fever endocarditis
    F Fenollar
    , Centre Nationale de Recherche Scientifique, , , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Clin Infect Dis 33:312-6. 2001
    Coxiella burnetii causes acute and chronic Q fever. To evaluate the risk factors of development of chronic endocarditis following Q fever and to assess the best preventive therapy, a retrospective study of patients diagnosed as having Q ..
  51. ncbi Q fever in humans and animals in the United States
    Jennifer H McQuiston
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Vector Borne Zoonotic Dis 2:179-91. 2002
    Coxiella burnetii, the etiologic agent of Q fever, is a worldwide zoonotic pathogen. Although Q fever is present in the United States, little is known about its current incidence or geographic distribution in either humans or animals...
  52. pmc Comparison of PCR and serology assays for early diagnosis of acute Q fever
    Pierre Edouard Fournier
    IFR 48 CNRS UMR 6020, Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
    J Clin Microbiol 41:5094-8. 2003
    b>Q fever is a potentially severe disease which can occur in large outbreaks of acute infections and is a possible bioterrorism agent...
  53. ncbi Cardiac valves in patients with Q fever endocarditis: microbiological, molecular, and histologic studies
    Hubert Lepidi
    Unite des Rickettsies, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 6020, Institut Federatif de Recherche 48, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    J Infect Dis 187:1097-106. 2003
    The pathologic features of Q fever endocarditis, which is caused by Coxiella burnetii, were histologically evaluated in cardiac valves from 28 patients...
  54. ncbi From acute Q fever to endocarditis: serological follow-up strategy
    Cécile Landais
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 44:1337-40. 2007
    The serological evolution from acute Q fever to endocarditis is reported for 22 patients, with a median lag time of 3 months...
  55. ncbi Effect of vaccination with phase I and phase II Coxiella burnetii vaccines in pregnant goats
    Nathalie Arricau-Bouvery
    INRA, Pathologie Infectieuse et Immunologie, F 37380 Nouzilly, France
    Vaccine 23:4392-402. 2005
    Livestock is considered to be the major "source" of human Q fever. The efficacy of two currently available vaccines (Coxevac, phase I, CEVA Santé Animale and Chlamyvax FQ, phase II, MERIAL) against Coxiella excretion was investigated in ..
  56. ncbi Developmental biology of Coxiella burnettii
    R A Heinzen
    Dept of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
    Trends Microbiol 7:149-54. 1999
    The obligate intracellular bacterial agent of human Q fever, Coxiella burnetii, has a remarkable ability to persist in the extracellular environment...
  57. ncbi Goats may experience reproductive failures and shed Coxiella burnetii at two successive parturitions after a Q fever infection
    M Berri
    INRA Tours Nouzilly, Infectiologie Animale et Sante Publique, 37380 Nouzilly, France
    Res Vet Sci 83:47-52. 2007
    b>Q fever is a zoonosis caused by the obligate intracellular bacterium, Coxiella burnetii. Aborting domestic ruminants are the main source of human infection...
  58. ncbi The Q fever epidemic in The Netherlands: history, onset, response and reflection
    H I J Roest
    Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    Epidemiol Infect 139:1-12. 2011
    The 2007-2009 human Q fever epidemic in The Netherlands attracted attention due to its magnitude and duration...
  59. pmc Antibodies against Coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in The Netherlands
    Wim van der Hoek
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Infect Dis 11:44. 2011
    b>Q fever has become a major public health problem in The Netherlands. Infection with Coxiella burnetii (Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases...
  60. ncbi Q Fever in dairy animals
    Annie Rodolakis
    INRA, UR 1282 Infectiologie Animale et Santé Publique, F 37380 Nouzilly
    Ann N Y Acad Sci 1166:90-3. 2009
    ..The review also discusses the diagnosis of Q fever in livestock and the possibility of Coxiella-free herds, and it reports the available methods for controlling Q ..
  61. pmc Coxiella burnetii shedding routes and antibody response after outbreaks of Q fever-induced abortion in dairy goat herds
    Elodie Rousset
    Agence Française de Sécurité Sanitaire des Aliments French Food Safety Agency AFSSA, Unité Pathologie des Ruminants Laboratory of Pathologies in Ruminants, Sophia Antipolis, France
    Appl Environ Microbiol 75:428-33. 2009
    b>Q fever is a zoonosis caused by Coxiella burnetii, a bacterium largely carried by ruminants and shed into milk, vaginal mucus, and feces...
  62. ncbi Managing Q fever during pregnancy: the benefits of long-term cotrimoxazole therapy
    Xavier Carcopino
    Service de Gynecologie Obstetrique, Hopital Nord, Chemin des Bourrely, France
    Clin Infect Dis 45:548-55. 2007
    b>Q fever is a zoonosis caused by Coxiella burnetii. During pregnancy, it may result in obstetric complications, such as spontaneous abortion, intrauterine growth retardation, intrauterine fetal death, and premature delivery...
  63. ncbi Shedding routes of Coxiella burnetii in dairy cows: implications for detection and control
    Raphaël Guatteo
    Unit of Animal Health Management, Veterinary School and INRA, BP 40706, 44307 Nantes Cedex 03, France
    Vet Res 37:827-33. 2006
    ..Testing a cow based on only one type of biological sample may lead to misclassify it with regards to its shedding of Coxiella burnetii and thereby underestimate the risk of bacterial spread within a herd...
  64. pmc Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons
    Paul A Beare
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
    J Bacteriol 188:2309-24. 2006
    Coxiella burnetii, a gram-negative obligate intracellular bacterium, causes human Q fever and is considered a potential agent of bioterrorism. Distinct genomic groups of C...
  65. ncbi Comparison of Coxiella burnetii shedding in milk of dairy bovine, caprine, and ovine herds
    A Rodolakis
    INRA, UR1282, Infectiologie Animale et Sante Publique, Centre de Recherche de Tours, 37380 Nouzilly, France
    J Dairy Sci 90:5352-60. 2007
    ..In contrast, the ewes, which came from flocks with abortions due to Q fever (C. burnetii infection), shed the bacteria mostly in feces and in vaginal mucus...
  66. ncbi Blood culture-negative endocarditis in a reference center: etiologic diagnosis of 348 cases
    Pierre Houpikian
    Unitué des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, CNRS UPRES A 6020, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Medicine (Baltimore) 84:162-73. 2005
    ..Finally, no explanatory factor was found for 5 remaining cases (1%), despite all investigations.Q fever endocarditis affected males in 75% of cases, between 40 and 70 years of age...
  67. pmc Identification and cloning of immunodominant antigens of Coxiella burnetii
    Guoquan Zhang
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    Infect Immun 72:844-52. 2004
    ..These results suggest that these proteins may play critical roles in the development of protective immunity and that they are logical candidates for vaccine and serodiagnostic reagents...
  68. ncbi Mechanisms of vaccine-induced protective immunity against Coxiella burnetii infection in BALB/c mice
    Guoquan Zhang
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    J Immunol 179:8372-80. 2007
    ..burnetii infection. This report presents novel evidence to highlight the importance of PI-LPS and Abs in protective immunity and has important implications for the design of new generation vaccines against Q fever.
  69. ncbi Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak
    L M Kampschreur
    Division of Medicine, Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
    Epidemiol Infect 141:847-51. 2013
    The Netherlands experienced an unprecedented outbreak of Q fever between 2007 and 2010. The Jeroen Bosch Hospital (JBH) in 's-Hertogenbosch is located in the centre of the epidemic area...
  70. pmc A super-spreading ewe infects hundreds with Q fever at a farmers' market in Germany
    Klaudia Porten
    Robert Koch Institute Seestrasse 10, 13353 Berlin, Germany
    BMC Infect Dis 6:147. 2006
    ..In May 2003 the Soest County Health Department was informed of an unusually large number of patients hospitalized with atypical pneumonia...
  71. ncbi Chronic Q fever: review of the literature and a proposal of new diagnostic criteria
    M C A Wegdam-Blans
    Department of Medical Microbiology, Laboratory for Pathology and Medical Microbiology PAMM, Veldhoven, The Netherlands
    J Infect 64:247-59. 2012
    A review was performed to determine clinical aspects and diagnostic tools for chronic Q fever. We present a Dutch guideline based on literature and clinical experience with chronic Q fever patients in The Netherlands so far...
  72. ncbi Q fever
    Neil R Parker
    Darling Downs Public Health Unit, Queensland Health, Australia
    Lancet 367:679-88. 2006
    b>Q fever is a zoonosis with many manifestations. The most common clinical presentation is an influenza-like illness with varying degrees of pneumonia and hepatitis...
  73. ncbi Long-term persistence of Coxiella burnetii after acute primary Q fever
    B P Marmion
    Q Fever Research Group, Infectious Diseases Laboratories, IMVS and Hanson Institute, Adelaide, South Australia
    QJM 98:7-20. 2005
    Long-term persistence of C. burnetii in infected animals was established in the 1950s and 60s, but the implications for human Q fever are not fully explored.
  74. pmc Q fever among culling workers, the Netherlands, 2009-2010
    Jane Whelan
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 17:1719-23. 2011
    In 2009, dairy goat farms in the Netherlands were implicated in >2,300 cases of Q fever; in response, 51,820 small ruminants were culled. Among 517 culling workers, despite use of personal protective equipment, 17...
  75. ncbi Long-term outcome of Q fever endocarditis: a 26-year personal survey
    Matthieu Million
    Universite de la Mediterranee, Marseille, France
    Lancet Infect Dis 10:527-35. 2010
    b>Q fever endocarditis caused by Coxiella burnetii is a potentially fatal disease characterised by a chronic evolution...
  76. ncbi Acute Q fever: an emerging and endemic disease in southern Taiwan
    Chung Hsu Lai
    Sections of Infectious Diseases, Department of Internal Medicine, E Da Hospital I Shou University, Kaoshiung County, Taiwan, Republic of China
    Scand J Infect Dis 40:105-10. 2008
    Acute Q fever is a worldwide zoonosis caused by Coxiella burnetii infection. In Taiwan, cases of acute Q fever increased during 3 y of observation, especially at Kaohsiung County and City in southern Taiwan...
  77. pmc Role of CD4+ and CD8+ T cells in clearance of primary pulmonary infection with Coxiella burnetii
    Amanda J Read
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717, USA
    Infect Immun 78:3019-26. 2010
    ..However, compared to CD4+ T-cell-dependent protection, CD8+ T-cell-dependent protection resulted in less inflammation in the lungs and less growth of bacteria in the spleens...
  78. ncbi Prevalence of Coxiella burnetii infection in domestic ruminants: a critical review
    Raphaël Guatteo
    INRA, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, Nantes F 44307, France
    Vet Microbiol 149:1-16. 2011
    ..Reliable detection of Coxiella burnetii is a critical point for the control of the spread of this zoonotic disease (Q fever), ruminants being considered as the main source for human infection as confirmed by the recent human outbreak in ..
  79. pmc Immunoreactive Coxiella burnetii Nine Mile proteins separated by 2D electrophoresis and identified by tandem mass spectrometry
    James R Deringer
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    Microbiology 157:526-42. 2011
    Coxiella burnetii is a Gram-negative obligate intracellular pathogen and the causative agent of Q fever in humans. Q fever causes acute flu-like symptoms and may develop into a chronic disease leading to endocarditis...
  80. ncbi Life on the outside: the rescue of Coxiella burnetii from its host cell
    Anders Omsland
    Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Annu Rev Microbiol 65:111-28. 2011
    For over seven decades, Coxiella burnetii, the causative agent of human Q fever, has been considered a prototypical obligate intracellular bacterium that relies exclusively on a eukaryotic cell for growth...
  81. ncbi Analysis of whole cell lysate from the intercellular bacterium Coxiella burnetii using two gel-based protein separation techniques
    Georgios Samoilis
    Division of Biochemistry, Department of Chemistry, University of Crete, P O Box 2208, GR 71003 Voutes, Greece
    J Proteome Res 6:3032-41. 2007
    Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular gamma-proteobacterium, which replicates within large phagolysosome-like compartments formed in the host cell. The global protein profile of intracellular C...
  82. ncbi [Laboratory diagnosis of acute Q fever]
    Marjolijn C A Wegdam-Blans
    Stichting PAMM, Afdeling Medische Microbiologie, Veldhoven, The Netherlands
    Ned Tijdschr Geneeskd 154:A2388. 2010
    ..Reporting of both confirmed and suspected cases of acute Q-fever is obligatory...
  83. ncbi Prevalence of Coxiella burnetii infection in Dutch dairy herds based on testing bulk tank milk and individual samples by PCR and ELISA
    J Muskens
    Animal Health Service, 7400 AA Deventer, The Netherlands
    Vet Rec 168:79. 2011
    ..7 per cent) lactating cows; bacterial DNA was not detected in any of the faecal samples obtained from youngstock. The blood and milk samples were taken from the cattle in the period January to April 2008...
  84. ncbi Q fever and pregnancy: disease, prevention, and strain specificity
    E Angelakis
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculte de Medecine, CNRS UMR 7278, IRD 198, Aix Marseille Universite, 27 Bd Jean Moulin, 13005 Marseille, France
    Eur J Clin Microbiol Infect Dis 32:361-8. 2013
    The link between fetal morbidity and Q fever and the necessity of long-term antibiotics for Coxiella burnetii infection during pregnancy have been recently questioned in the Netherlands, where the clone responsible for the Q fever ..
  85. ncbi Q fever seroprevalence and associated risk factors among students from the Veterinary School of Zaragoza, Spain
    M C Valencia
    Depto de Patologia Animal Enfermedades Infecciosas y Epidemiologia, Universidad de Zaragoza, Spain
    Eur J Epidemiol 16:469-76. 2000
    b>Q fever is a zoonosis related to the existence of Coxiella burnetii infected animals. The authors studied the seroprevalence and risk factors associated to C. burnetii infection in veterinary students in Zaragoza (Spain)...
  86. pmc Detection of Coxiella burnetii DNA on small-ruminant farms during a Q fever outbreak in the Netherlands
    A de Bruin
    National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb, Bilthoven, Netherlands
    Appl Environ Microbiol 78:1652-7. 2012
    During large Q fever outbreaks in the Netherlands between 2007 and 2010, dairy goat farms were implicated as the primary source of human Q fever...
  87. ncbi Outbreak of Q fever associated with a horse-boarding ranch, Colorado, 2005
    Wendy M Bamberg
    Epidemic Intelligence Service, Colorado Department of Public Health and Environment, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Vector Borne Zoonotic Dis 7:394-402. 2007
    Coxiella burnetii is a bacterium located worldwide that can cause Q fever when inhaled. We describe an outbreak of Q fever associated with a horse-boarding ranch that had acquired two herds of goats...
  88. pmc Evaluation of a diagnostic algorithm for acute Q fever in an outbreak setting
    Mischa M Jager
    Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 5200 ME s Hertogenbosch, Netherlands
    Clin Vaccine Immunol 18:963-8. 2011
    In the peak of the 2009 Q fever outbreak in the Netherlands, we introduced a diagnostic algorithm for acute Q fever with an enzyme-linked immunosorbent assay for immunoglobulin M antibodies to Coxiella burnetii phase II antigens (MII ..
  89. ncbi Pulmonary disease from biological agents: anthrax, plague, Q fever, and tularemia
    Mohamud Daya
    Department of Emergency Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd Portland, OR 97239 3098, USA
    Crit Care Clin 21:747-63, vii. 2005
    Anthrax, plague, Q fever, and tularemia are all potential inhalational bioterrorism agents...
  90. ncbi Coxiella burnetii: host and bacterial responses to infection
    David M Waag
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Vaccine 25:7288-95. 2007
    ..This review is intended to provide a basic introduction to C. burnetii and Q fever, while emphasizing immunomodulatory properties, both positive and negative, of Q fever vaccines and C...
  91. ncbi Serological diagnosis and follow-up of asymptomatic and acute Q fever infections
    Christiane Wagner-Wiening
    Q fever Consulting Laboratory, Baden Wurttemberg, State Health Office, Wiederholdstr 15, D 70174 Stuttgart, Germany
    Int J Med Microbiol 296:294-6. 2006
    During an outbreak of Q fever at a farmer's market in Soest (North Rhine-Westphalia, Germany) in 2003, we examined 263 serum samples of presumably infected persons for Q fever antibodies...
  92. ncbi Acute hepatitis with or without jaundice: a predominant presentation of acute Q fever in southern Taiwan
    Ko Chang
    Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University, University Hospital, 138 Sheng Li Road, Tainan, Taiwan 704, ROC
    J Microbiol Immunol Infect 37:103-8. 2004
    Acute Q fever was previously regarded as an uncommon infectious disease in Taiwan but has been increasingly recognized recently...
  93. pmc Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: macrophages from restrictive strains control parasitophorous vacuole maturation
    Dario S Zamboni
    Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, São Paulo SP 04023 062, Brazil
    Infect Immun 72:2395-9. 2004
    ..However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs...
  94. pmc Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands
    A de Bruin
    National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb, Laboratory for Zoonoses and Environmental Microbiology, Bilthoven, The Netherlands
    Appl Environ Microbiol 77:6516-23. 2011
    b>Q fever, caused by Coxiella burnetii, is a zoonosis with a worldwide distribution. A large rural area in the southeast of the Netherlands was heavily affected by Q fever between 2007 and 2009...
  95. ncbi Seroprevalence of Q fever, brucellosis and leptospirosis in farmers and agricultural workers in Bari, Southern Italy
    Rosa Monno
    Department of Internal Medicine and Public Health, Hygiene Section, School of Medicine, University of Bari, Italy, Piazza G Cesare 11, 70124 Bari, Italy
    Ann Agric Environ Med 16:205-9. 2009
    ..None of the subjects examined had antibodies to Leptospira and Brucella. Further improvements in the occupational hygiene of the work environment is advisable...
  96. ncbi Emerging evidence for Q fever in humans in Denmark: role of contact with dairy cattle
    E Bosnjak
    Department of Infectious Diseases, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Clin Microbiol Infect 16:1285-8. 2010
    Until recently, Q fever was notified in very low numbers annually in Denmark and it was always considered to be acquired abroad. Preliminary reports now describe Coxiella burnetii in milk samples from Danish dairy cattle...
  97. ncbi Coxiella burnetii infection among blood donors during the 2009 Q-fever outbreak in The Netherlands
    Boris M Hogema
    Department of Blood borne Infections, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands
    Transfusion 52:144-50. 2012
    ..To assess the extent of infection and the safety of donated blood, we tested local blood donations for presence of Coxiella burnetii antibodies and DNA...
  98. ncbi Q fever: the neglected biothreat agent
    P C F Oyston
    Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 60:9-21. 2011
    Coxiella burnetii is the causative agent of Q fever, a disease with a spectrum of presentations from the mild to fatal, including chronic sequelae...
  99. ncbi Acute Q fever in adult patients: report on 63 sporadic cases in an urban area
    P Domingo
    Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Clin Infect Dis 29:874-9. 1999
    We report here 63 sporadic urban cases of acute Q fever diagnosed in 1985-1997. Fifty-eight men and five women were included; the mean age (+/- SD) was 35.6 (+/- 10.2) years...
  100. ncbi Q fever: still more queries than answers
    Corine E Delsing
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Adv Exp Med Biol 719:133-43. 2011
    b>Q fever is a worldwide zoonosis, caused by C. burnetii. Infection usually occurs through inhalation of infected aerosols. The reservoir mainly consists of dairy cattle...
  101. pmc Has Coxiella burnetii (Q fever) been introduced into New Zealand?
    Erik Greenslade
    Emerg Infect Dis 9:138-40. 2003

Research Grants36

  1. Role of Coxiella burnetii group I introns in growth modulation
    Michael F Minnick; Fiscal Year: 2010
    ..by applicant): Coxiella burnetii is an extremely infectious, obligate intracellular bacterium that causes Q fever, and is classified as a Select B Agent...
  2. Development of Site-Specific Mutagenesis in Coxiella burnetti
    JAMES EVANS SAMUEL; Fiscal Year: 2012
    ..burnetii and a major contribution to new approaches to investigate the pathogenic process of Q fever. PUBLIC HEALTH RELEVANCE: Infections of humans with Coxiella burnetii, a potential bioterrorism agent, manifest ..
  3. Small Regulatory RNAs of Coxiella burnetii - The Agent of Q Fever
    JAMES MICHAEL BATTISTI; Fiscal Year: 2013
    ..provided by applicant): Coxiella burnetii is an extremely infectious, intracellular bacterium that causes Q fever in humans and is classified as a select agent...
  4. The Role of Antibody-Mediated Protective Immunity Against Q fever
    Guoquan Zhang; Fiscal Year: 2010
    ..Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes the worldwide zoonotic disease, Q fever. Natural human infections commonly occur via inhalation of infectious aerosols, manifest clinically as atypical ..
  5. Analysis of the Coxiella burnetii Type IV Secretion System During Infection
    Edward I Shaw; Fiscal Year: 2012
    ..It is the etiologic agent of acute Q fever and chronic diseases such as endocarditis, hepatitis, and chronic fatigue. Acquired by inhalation, C...
  6. Functional Characterization of Coxiella burnetii Dot/Icm Substrates
    Daniel E Voth; Fiscal Year: 2010
    Coxiella burnetii is an obligate intracellular bacterial pathogen and the etiologic agent of human Q fever. Q fever typically presents as an acute debilitating flu-like illness but can progress to severe, chronic endocarditis...
  7. Innate Immune Response to Coxiella burnetii Infection
    MATTHEW D CALVERLEY; Fiscal Year: 2010
    ..burnetii, an NIAID category B priority pathogen and select agent, is the causative agent of the zoonotic disease Q fever. In humans, this febrile disease is frequently acquired via inhalation and is characterized by pneumonia with ..
  8. Characterizing the role of type IV-secreted CpeD and CpeE in Coxiella burnetii in
    Daniel E Voth; Fiscal Year: 2013
    ..by applicant): Coxiella burnetii is an intracellular bacterial pathogen and the etiologic agent of human Q fever, an acute debilitating flu-like illness that can progress to chronic endocarditis...
  9. A Systems Biology Approach for Investigating Coxiella burneti Infection
    JUSTIN ANDREW MCDONOUGH; Fiscal Year: 2010
    ....
  10. Development of O Antigen-based Vaccines Against Q Fever
    Guoquan Zhang; Fiscal Year: 2013
    ..provided by applicant): Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes acute Q fever and chronic infections in humans...
  11. Coxiella burnetii Regulation of Macrophage cAMP/PKA Signaling
    Daniel E Voth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coxiella burnetii is the intracellular bacterial agent of human Q fever, a debilitating flu-like illness that can also present as severe chronic endocarditis. C...
  12. Identification and Role of Type IV Effector Proteins in Coxiella burnetii
    JAMES EVANS SAMUEL; Fiscal Year: 2010
    ..These data will be used to expand out understanding of the pathogenic process in Q fever and identify targets for anti-C. burnetii therapy.
  13. Role of Toll-like receptors in Coxiella burnetii infection
    Mark A Jutila; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Even though C. burnetii has been recognized as the Q fever agent since the 1930s, we still have an incomplete understanding of host cell entry, disease pathogenesis or how the agent avoids immune ..
  14. Identification and Role of Type IV Effector Proteins in Coxiella burnetii
    JAMES EVANS SAMUEL; Fiscal Year: 2013
    ..These data will be used to expand our understanding of the pathogenic process in Q fever and identify targets for anti-C. burnetii therapy.
  15. An Inhalation Model of Q Fever in Guinea Pigs
    Kasi Russell; Fiscal Year: 2005
    b>Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Due to the highly infectious nature of C...
  16. Pathogenic Roles of Coxiella burnetti Proteins
    James Samuel; Fiscal Year: 2007
    Coxiella burnetii, the etiologic agent of Q fever, is an obligate intraceilular bacteria that replicates within an apparently unmodified phagolysosome...
  17. Multiplexed POC Diagnostic System for Bio-Threat Agents
    GEORGE SIGAL; Fiscal Year: 2005
    ..ten threat agents: Bacillus anthracis (BA), Yersinia pestis (YP), Francisella tularensis (FT), Coxiella burnetii (Q Fever), Brucellosis ssp, vaccinia virus, Venezuelan Equine Encephalitis (VEE), botulinum toxin A, ricin, and ..
  18. VIRULENCE IN COXIELLA BURNETTII
    HERBERT THOMPSON; Fiscal Year: 1999
    ..Individual genes then suspected to be important for virulence will be studied by knockout mutations. The proposed experiments are the first to examine C. burnetii by genetic transformation. ..
  19. SURFACE CHANGE AND VIRULENCE IN COXIELLA BURNETII
    Michael Kahn; Fiscal Year: 1999
    ..from the applicant's abstract): Coxiella burnetii is an obligate intracellular bacterium which causes both acute Q fever and chronic endocarditis in humans. While information has accumulated concerning aspects of C...
  20. PATHOGENIC ROLES OF COXIELLA BURNETTI SURFACE PROTEINS
    James Samuel; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Coxiella burnetii, the etiologic agent of Q fever, is an obligate intracellular bacterium that replicates within an apparently unmodified phagolysosome...
  21. VACCINE INTERVENTION AGAINST Q FEVER
    James Samuel; Fiscal Year: 2003
    ..The agent causes acute Q fever, occasional chronic disease, and very recently was linked to chronic vascular disease...
  22. Identification of T Cell Antigen For Q Fever Vaccination
    James Samuel; Fiscal Year: 2009
    ..burnetti strains;and 3] Immunization with C. burnetii antigens and determination of protective immunity against homologous and heterologous strain challenge. ..
  23. American Society for Rickettsiology Conference 2009
    ROMAN GANTA; Fiscal Year: 2009
    ..diseases as well as the more distantly related, but important pathogens, such as Coxiella burnetii (the Q fever agent) and Bartonella species...
  24. WHOLE GENOME SEQUENCING OF COXIELLA BURNETTI
    John Heidelberg; Fiscal Year: 2000
    The zoonotic disease Q fever is a caused by the obligate intracellular bacterium Coxiella burnetii. Coxiella burnetii has evolved strategies to survive in the hostile phagolysosomal environment...
  25. Characterization of the Coxiella Dot/lcm homologues
    JOSEPH VOGEL; Fiscal Year: 2006
    Coxiella burnetii is a Gram negative bacterium that causes the zoonotic illness Q fever (for query fever)...
  26. T-DNA INTEGRATION DURING CROWN GALL TUMORIGENESIS
    LLOYD REAM; Fiscal Year: 1991
    ..Agrobacterium and rickettsiae (bacteria which cause trench fever, Q fever, and Rocky Mountain spotted fever in humans) share lifestyle similarities (close association with eukaryotic host ..
  27. Novel vaccine adjuvants to counter bioterrorist threats
    Nikolai Petrovsky; Fiscal Year: 2009
    ..g. Q Fever, Shigella, flaviviruses, small pox, SARS), proof of concept studies demonstrating vaccine protection in validated ..
  28. Bartonella Inhibitory Factor for Endothelial Cell Growth
    MICHAEL MINNICK; Fiscal Year: 2002
    ..abstract_text> ..
  29. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..abstract_text> ..
  30. ACTIN BASED MOTILITY BY RICKETTSIA RICKETTSII
    ROBERT HEINZEN; Fiscal Year: 2002
    ..Not only will these studies lead to a greater understanding of molecular mechanisms of rickettsial pathogenesis, but they will also provide insight into the dynamic control of actin polymerization. ..
  31. Generation of Genetically Attenuated Rickettsiae
    Abdu Azad; Fiscal Year: 2009
    ..The underlying hypothesis tested is whether recombinant strains with altered genes maintain their immunogenicity within mammals and provide cross protection to subsequent challenge with virulent strains. ..
  32. BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGES
    Abdu Azad; Fiscal Year: 2005
    ..falciparum EE-stages. Finally, we will define the contribution of P. yoelii liver-stage gene products in protective immunity via DNA immunizations. ..
  33. Murine Typhus: Vector Biology & Transmission
    Abdu Azad; Fiscal Year: 2007
    ..typhi and ELB upon challenge with[unreadable] the heterologous rickettsiae and involvement of 120 kDa in the protection.[unreadable] [unreadable]..