haemophilus infections

Summary

Summary: Infections with bacteria of the genus HAEMOPHILUS.

Top Publications

  1. pmc Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach
    Hongbo Chen
    Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, PR China
    BMC Genomics 10:64. 2009
  2. ncbi Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, N C, USA
    J Innate Immun 1:215-24. 2009
  3. ncbi Nontypeable Haemophilus influenzae as a pathogen in children
    Timothy F Murphy
    University at Buffalo, The State University of New York, Buffalo, NY
    Pediatr Infect Dis J 28:43-8. 2009
  4. pmc Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein
    Joseph A Jurcisek
    Columbus Children s Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, 700 Children s Drive, Columbus, OH 43205 2696, USA
    J Bacteriol 189:3868-75. 2007
  5. ncbi Molecular characterization of caveolin-1 in pigs infected with Haemophilus parasuis
    Xiang Dong Liu
    Key Laboratory of Agricultural Animal Genetics and Breeding, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    J Immunol 186:3031-46. 2011
  6. ncbi Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination
    H J Adam
    Department of Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada
    Vaccine 28:4073-8. 2010
  7. pmc Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Infect Immun 75:958-65. 2007
  8. pmc Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular traps
    Richard A Juneau
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5053 Hanes Building, 1000 Medical Center Boulevard, Winston Salem, NC 27157, USA
    Infect Immun 79:431-8. 2011
  9. pmc Relative importance of nasopharyngeal versus oropharyngeal sampling for isolation of Streptococcus pneumoniae and Haemophilus influenzae from healthy and sick individuals varies with age
    David Greenberg
    The Pediatric Infectious Disease Unit, Ben Gurion University of the Negev, Soroka University Medical Center, Beer Sheva, Israel
    J Clin Microbiol 42:4604-9. 2004
  10. ncbi Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York and the Veterans Affairs Western New York Healthcare System, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 170:266-72. 2004

Detail Information

Publications281 found, 100 shown here

  1. pmc Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach
    Hongbo Chen
    Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, PR China
    BMC Genomics 10:64. 2009
    ..In this study, we investigated the global changes in gene expression in the spleen following HPS infection using the Affymetrix Porcine Genechip...
  2. ncbi Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, N C, USA
    J Innate Immun 1:215-24. 2009
    ..These data support the conclusion that NTHi subverts neutrophil extracellular traps to persist in vivo. These data also indicate that a more inclusive definition for biofilms may be warranted...
  3. ncbi Nontypeable Haemophilus influenzae as a pathogen in children
    Timothy F Murphy
    University at Buffalo, The State University of New York, Buffalo, NY
    Pediatr Infect Dis J 28:43-8. 2009
    ..influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D...
  4. pmc Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein
    Joseph A Jurcisek
    Columbus Children s Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, 700 Children s Drive, Columbus, OH 43205 2696, USA
    J Bacteriol 189:3868-75. 2007
    ....
  5. ncbi Molecular characterization of caveolin-1 in pigs infected with Haemophilus parasuis
    Xiang Dong Liu
    Key Laboratory of Agricultural Animal Genetics and Breeding, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    J Immunol 186:3031-46. 2011
    ..In addition, our results suggest that Cav1 may be implicated in the pathogenesis of Glasser's disease, which is caused by H. parasuis...
  6. ncbi Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination
    H J Adam
    Department of Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada
    Vaccine 28:4073-8. 2010
    ..influenzae infection now commonly presents as sepsis due to non-typeable H. influenzae in older individuals. However, strain replacement of Hib with serotype f and non-typeable strains in children under 5 years was documented...
  7. pmc Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Infect Immun 75:958-65. 2007
    ..We thus conclude that PCho promotes NTHi infection and persistence by reducing the host inflammatory response and by promoting formation of stable biofilm communities...
  8. pmc Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular traps
    Richard A Juneau
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5053 Hanes Building, 1000 Medical Center Boulevard, Winston Salem, NC 27157, USA
    Infect Immun 79:431-8. 2011
    ..These data support the conclusion that, for NTHI, formation of NET structures may be a persistence determinant by providing a niche within the middle-ear chamber...
  9. pmc Relative importance of nasopharyngeal versus oropharyngeal sampling for isolation of Streptococcus pneumoniae and Haemophilus influenzae from healthy and sick individuals varies with age
    David Greenberg
    The Pediatric Infectious Disease Unit, Ben Gurion University of the Negev, Soroka University Medical Center, Beer Sheva, Israel
    J Clin Microbiol 42:4604-9. 2004
    ..Culturing only one site significantly reduced the recovery of H. influenzae at all ages. NP cultures for S. pneumoniae detected close to 100% of isolates in children but only 58% of isolates in mothers...
  10. ncbi Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York and the Veterans Affairs Western New York Healthcare System, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 170:266-72. 2004
    ..influenzae and that sputum cultures underestimate the frequency of colonization of the respiratory tract by H. influenzae in COPD. This observation has a significant impact on understanding bacterial colonization in COPD...
  11. ncbi Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 195:81-9. 2007
    ..In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype. We tested the hypothesis that these variant strains were genetically different from typical H. influenzae...
  12. pmc Antimicrobial resistance in Haemophilus influenzae
    Stephen Tristram
    School of Human Life Sciences, University of Tasmania, Locked Bag 1320, Launceston 7250, Australia
    Clin Microbiol Rev 20:368-89. 2007
    ..The activity of many oral agents is limited by pharmacokinetics achieved with administration by this route, and the susceptibility of isolates based on pharmacokinetic and pharmacodynamic parameters is reviewed...
  13. pmc Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing
    Emma Meats
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital, London W2 1PG, United Kingdom
    J Clin Microbiol 41:1623-36. 2003
    ..The H. influenzae MLST scheme is available at www.mlst.net, it allows any isolate to be compared with those in the MLST database, and (for encapsulated isolates) it assigns isolates to their phylogenetic lineage, via the Internet...
  14. ncbi Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Vaccine 28:71-8. 2009
    ..influenzae was still reduced with 38.6% (95% CI: -6.3 to 64.6, ns). Reduction of acute otitis media (AOM) episodes preceded the impact on carriage. These data provide further support of the functional role of the protein D immunity...
  15. pmc RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP
    Chelsie E Armbruster
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Mol Microbiol 82:836-50. 2011
    ..Based on these data, we conclude that in NTHI 86-028NP, RbsB is a LuxS/AI-2 regulated protein that is required for uptake of and response to AI-2...
  16. pmc Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era
    Aarti Agrawal
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    J Clin Microbiol 49:3728-32. 2011
    ..The introduction of vaccines for otitis media and global shifts in antimicrobial susceptibility emphasize the importance of continued surveillance of H. influenzae colonization and disease patterns...
  17. ncbi Bacterial otitis media: a vaccine preventable disease?
    Allan W Cripps
    School of Medicine, Griffith University, Gold Coast Campus, PMB 50, Gold Coast MC, QLD 9726, Australia
    Vaccine 23:2304-10. 2005
    ..A combined bacterial-viral vaccine formulation would produce the most profound and sustained impact on reducing the global incidence of OM...
  18. ncbi Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media
    Daniel J Morton
    Department of Pediatrics, University of Oklahoma Health Sciences Center, CHO 2308, 940 NE 13th Street, Oklahoma City, OK 73104, USA
    Microb Pathog 36:25-33. 2004
    ..These data indicate that the hemoglobin/hemoglobin-haptoglobin binding proteins are required for bacterial proliferation during H. influenzae-induced otitis media in chinchillas...
  19. pmc Expression of cytokine genes during pneumococcal and nontypeable Haemophilus influenzae acute otitis media in the rat
    A Melhus
    Department of Surgery Otolaryngology, University of California at San Diego School of Medicine and Veterans Affairs Medical Center, La Jolla, California, USA
    Infect Immun 68:4024-31. 2000
    ..Most of the investigated cytokines are very early markers for AOM and may be involved in initiation of inflammation, but they would be poor targets for pharmacological manipulation since their levels decline before clinical signs appear...
  20. ncbi Serum-resistance in Haemophilus parasuis is associated with systemic disease in swine
    Marta Cerdà-Cuéllar
    Centre de Recerca en Sanitat Animal CReSA, Campus de Bellaterra Universitat, Autonoma de Barcelona, Barcelona, Spain
    Vet J 175:384-9. 2008
    ..The results indicate that serum-resistance is a virulence mechanism in H. parasuis...
  21. pmc A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media
    Daniel J Morton
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    BMC Res Notes 5:327. 2012
    ..Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient...
  22. ncbi Survival of nontypeable Haemophilus influenzae in macrophages
    J E Craig
    University of Manchester, School of Biological Sciences, 1.800, Stopford Building, Manchester M13 9PT, UK
    FEMS Microbiol Lett 203:55-61. 2001
    ..The number of viable organisms recovered at this time ranged from 2x10(4) to 50 colony-forming units per strain indicating that the extent to which nontypeable H. influenzae can resist macrophage-mediated killing varies between strains...
  23. ncbi Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
    ..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia...
  24. ncbi Current epidemiology and trends in invasive Haemophilus influenzae disease--United States, 1989-2008
    Jessica R MacNeil
    Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 53:1230-6. 2011
    ..With the introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines, there has been a dramatic reduction of Hib disease in young children and the epidemiological trends of invasive H. influenzae have shifted...
  25. ncbi Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media
    Galia Barkai
    Soroka University Medical Center, Beer Sheva, Israel
    Pediatr Infect Dis J 28:466-71. 2009
    ..To characterize NTHi AOM a large database of culture-positive AOM cases was analyzed...
  26. ncbi Porcine S100A8 and S100A9: molecular characterizations and crucial functions in response to Haemophilus parasuis infection
    Hongbo Chen
    Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, Hubei, PR China
    Dev Comp Immunol 35:490-500. 2011
    ..A pS100A8/pS100A9-CASP3-SLC1A2 pathway regulating lipid metabolism was found. Both of their pro- and anti-inflammatory functions in response to HPS infection are highlighted...
  27. pmc Detection of cryptic genospecies misidentified as Haemophilus influenzae in routine clinical samples by assessment of marker genes fucK, hap, and sodC
    Niels Nørskov-Lauritsen
    Department of Clinical Microbiology, Aarhus University Hospital Skejby, Denmark
    J Clin Microbiol 47:2590-2. 2009
    ..influenzae genotype were characterized by phenotype and 16S rRNA gene sequencing. Two of 480 isolates were finally classified as variant strains ("nonhemolytic Haemophilus haemolyticus")...
  28. pmc Gene expression profiling in the lungs of pigs with different susceptibilities to Glässer's disease
    Jamie M Wilkinson
    Department of Veterinary Medicine, University of Cambridge, Madingley Rd, Cambridge, CB3 0ES, UK
    BMC Genomics 11:455. 2010
    ..parasuis in a bacterial challenge experiment...
  29. pmc Haemophilus haemolyticus isolates causing clinical disease
    Raydel Anderson
    Meningitis and Vaccine Preventable Disease Branch, Division of Bacterial Diseases, National Center for Infectious and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 50:2462-5. 2012
    ..All cases had different symptoms and presentations. Our study suggests that a testing scheme that includes reliable PCR assays and standard microbiological methods should be used in order to improve H. haemolyticus identification...
  30. ncbi Detailed structural features of lipopolysaccharide glycoforms in nontypeable Haemophilus influenzae strain 2019
    Mikael K R Engskog
    Clinical Research Centre, University College of South Stockholm, Karolinska Institutet, Stockholm, Novum, S 141 86 Huddinge, Sweden
    Carbohydr Res 346:1241-9. 2011
    ..Acetate groups and one glycine residue further substitute HepIII in NTHi 2019...
  31. pmc New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ....
  32. pmc Phosphorylcholine expression by nontypeable Haemophilus influenzae correlates with maturation of biofilm communities in vitro and in vivo
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5101A Gray Building, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Bacteriol 189:8300-7. 2007
    ..Collectively, these data show that PCho correlates with, and may promote, the maturation of NTHI biofilms. Further, this structure may be disadvantageous in the planktonic phase...
  33. ncbi Detection of Haemophilus influenzae in respiratory secretions from pneumonia patients by quantitative real-time polymerase chain reaction
    Guma M K Abdeldaim
    Department of Clinical Microbiology, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Diagn Microbiol Infect Dis 64:366-73. 2009
    ..influenzae in respiratory secretions. Quantification facilitates discrimination between disease-causing H. influenzae strains and commensal colonization...
  34. pmc Lipooligosaccharides containing phosphorylcholine delay pulmonary clearance of nontypeable Haemophilus influenzae
    Bing Pang
    Department of Microbiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Infect Immun 76:2037-43. 2008
    ..These results indicate that PCho promotes bacterial resistance to pulmonary clearance early in infection in a manner that is at least partially independent of the TLR4 pathway...
  35. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
    ..Our data thus indicate that CYLD acts as a negative regulator for NF-kappaB-dependent inflammation in vivo, hence protecting the host against detrimental inflammatory response to NTHi infection...
  36. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
    ..These data show that sialylated LOS glycoforms promote biofilm formation by NTHi and persistence in vivo...
  37. ncbi Adaptive immunity to nontypeable Haemophilus influenzae
    Paul T King
    Department of Respiratory Medicine, Monash Medical Centre, Monash University, Melbourne
    Am J Respir Crit Care Med 167:587-92. 2003
    ..Therefore, chronic infection with NTHi in bronchiectasis is associated with a change in adaptive immunity that may be important in the pathogenesis of bronchial infection...
  38. pmc ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae
    Sandy M S Wong
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Ave N, S6 242, Worcester, MA 01655, USA
    Infect Immun 79:1971-83. 2011
    ....
  39. pmc Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection
    L O Bakaletz
    Division of Otologic Research, Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus, Ohio, USA
    Infect Immun 67:2746-62. 1999
    ..001). Collectively, these data indicate the continued merit of further developing LB1 and LPD-LB1(f)2,1,3 as components of vaccines for otitis media...
  40. ncbi Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior
    Alice L Erwin
    Microbial Pathogens Program, Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109 5219, USA
    Trends Microbiol 15:355-62. 2007
    ..Successful commensalism requires dampening of the inflammatory response and evasion of host defenses, accomplished in part through phase variation...
  41. ncbi The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons > or = 65 years old
    Mark S Dworkin
    Division of Infectious Diseases, Illinois Department of Public Health, Chicago, IL 60612, USA
    Clin Infect Dis 44:810-6. 2007
    ..Few studies have reported the epidemiological characteristics of Haemophilus influenzae disease among adults...
  42. pmc Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein
    J N Weiser
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Exp Med 187:631-40. 1998
    ....
  43. pmc Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors
    J Angrill
    Unitat de Vigilància Intensiva Respiratòria, Servei de Pneumologia, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Villarroel 170, E 08036 Barcelona, Spain
    Thorax 57:15-9. 2002
    ..A study was undertaken to investigate the incidence, diagnostic yield of non-invasive and bronchoscopic techniques, and risk factors of airway colonisation in patients with bronchiectasis in a stable clinical situation...
  44. pmc Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection
    Thomas W Seale
    Department of Pediatrics, CHO 2308, University of Oklahoma Health Sciences Center, 940 NE 13th Street, Oklahoma City, OK 73104, USA
    Infect Immun 74:6213-25. 2006
    ..Taken together, these data indicate that both the hgp genes and the hxuC gene are virulence determinants in the rat model of human invasive disease...
  45. ncbi Respiratory infections caused by non-typeable Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Curr Opin Infect Dis 16:129-34. 2003
    ..In addition, newer developments in the areas of mechanisms of pathogenesis, host pathogen interaction, immune responses and efforts toward vaccine development will be reviewed briefly...
  46. ncbi Antibody to Haemophilus influenzae type b after routine and catch-up vaccination
    C L Trotter
    Immunisation Division, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Avenue, NW9 5EQ, London, UK
    Lancet 361:1523-4. 2003
    ..A second catch-up campaign in children aged 6 months to 4 years should be highly effective in boosting immunity and reducing disease in the short term...
  47. ncbi Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway
    Beinan Wang
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 277:949-57. 2002
    ..These studies may bring new insights into molecular pathogenesis of NTHi infections and lead to novel therapeutic intervention for COME and COPD...
  48. ncbi Population genetics and antibiotic susceptibility of invasive Haemophilus influenzae in Manitoba, Canada, from 2000 to 2006
    Michelle L Sill
    Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    FEMS Immunol Med Microbiol 51:270-6. 2007
    ..The results of this study suggest a shift in the epidemiology of invasive H. influenzae infections in the post-Hib vaccine era, and surveillance should include all serotypeable and NST isolates...
  49. pmc The role of DNA sensing and innate immune receptor TLR9 in otitis media
    Anke Leichtle
    Department of Surgery Otolaryngology, University of Lubeck, Lubeck, Germany
    Innate Immun 18:3-13. 2012
    ..The results suggest that DNA sensing via TLR9 plays a role in OM pathogenesis and recovery. Alternative forms of DNA sensing may also contribute to OM...
  50. pmc Relationships of nontypeable Haemophilus influenzae strains to hemolytic and nonhemolytic Haemophilus haemolyticus strains
    Kirk W McCrea
    Department of Epidemiology, University of Michigan School of Public Health Tower, 109 Observatory, Ann Arbor, MI 48109 2029, USA
    J Clin Microbiol 46:406-16. 2008
    ..Future comparative genomic studies identifying common and distinctive genes could be useful in evaluating their role in the commensal or virulent growth, respectively, of H. influenzae...
  51. ncbi Haemophilus parasuis: new trends on diagnosis, epidemiology and control
    Simone Oliveira
    Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, 385 Animal Science Veterinary Medicine, 1988 Fitch Avenue, Saint Paul, MN 55108, USA
    Vet Microbiol 99:1-12. 2004
    ..parasuis strains to reduce nursery mortality in affected swine herds...
  52. ncbi Antibody concentration and clinical protection after Hib conjugate vaccination in the United Kingdom
    P T Heath
    Department of Child Health and St George s Vaccine Institute, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, England
    JAMA 284:2334-40. 2000
    ..Few data are available to show that this fourth dose is actually necessary...
  53. ncbi Antibody avidity as a surrogate marker of successful priming by Haemophilus influenzae type b conjugate vaccines following infant immunization
    D Goldblatt
    Institute of Child Health, and Immunisation Division, Communicable Disease Surveillance Centre, London, United Kingdom
    J Infect Dis 177:1112-5. 1998
    ..Antibody avidity may help distinguish, in persons with low antibody titers, between those who are primed for memory and those who are not...
  54. pmc Two-component systems in Haemophilus influenzae: a regulatory role for ArcA in serum resistance
    J A De Souza-Hart
    Department of Genetics and Microbiology, University of Paris XI, Orsay, France
    Infect Immun 71:163-72. 2003
    ..Comparative analysis of the membrane fractions of the arcA mutants and the wild-type strain revealed several ArcA-regulated proteins, some of which may be implicated in the serum hypersensitivity phenotype...
  55. pmc The UK Hib vaccine experience
    P T Heath
    Department of Child Health and St George s Vaccine Institute, St George s Hospital Medical School, London, UK
    Arch Dis Child 86:396-9. 2002
    ..Cases continue to occur and complacency is ill advised, particularly as other vaccines and combinations are introduced. Surveillance of H influenzae disease in the UK remains important...
  56. pmc Invasive Haemophilus influenzae Disease, Europe, 1996-2006
    Shamez Ladhani
    Health Protection Agency, London, UK
    Emerg Infect Dis 16:455-63. 2010
    ..Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality...
  57. ncbi Invasive Haemophilus influenzae in British Columbia: non-Hib and non-typeable strains causing disease in children and adults
    Michelle Shuel
    Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2
    Int J Infect Dis 15:e167-73. 2011
    ..To characterize invasive Haemophilus influenzae and to examine the population at risk for invasive H. influenzae disease in British Columbia, Canada, 2008-2009...
  58. pmc Virulence-associated trimeric autotransporters of Haemophilus parasuis are antigenic proteins expressed in vivo
    Alex Olvera
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autònoma de Barcelona Edifici CReSA, 08193 Bellaterra, Barcelona, Spain
    Vet Res 41:26. 2010
    ..Taken together, these results indicate that VtaA are good candidate immunogens that could be used to improve H. parasuis vaccines. However, their capacity to confer protective immunity needs to be further studied...
  59. ncbi Immunogenicity and protection against Haemophilus parasuis infection after vaccination with recombinant virulence associated trimeric autotransporters (VtaA)
    Alex Olvera
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Barcelona, Spain
    Vaccine 29:2797-802. 2011
    ..The partial protection achieved with the recombinant VtaA supports their potential as candidates to be included in future vaccine formulations against H. parasuis...
  60. ncbi Invasive disease caused by Haemophilus influenzae in Sweden 1997-2009; evidence of increasing incidence and clinical burden of non-type b strains
    F Resman
    Medical Microbiology, Department of Laboratory Medicine, Lund University, Skane University Hospital, Malmo, Sweden
    Clin Microbiol Infect 17:1638-45. 2011
    ..The clinical burden of invasive non-type b H. influenzae disease, measured as days of hospitalization/100 000 individuals at risk and year, increased significantly throughout the study period...
  61. ncbi Otitis media: viruses, bacteria, biofilms and vaccines
    Helen M Massa
    Griffith Health, Griffith University, Gold Coast, QLD, Australia
    Med J Aust 191:S44-9. 2009
    ..Vaccine development is a key future direction for reducing the world burden of otitis media, but requires polymicrobial formulation and ongoing monitoring and modification to ensure sustained reduction in disease burden...
  62. pmc Immunologic memory in Haemophilus influenzae type b conjugate vaccine failure
    J McVernon
    Oxford Vaccine Group, University of Oxford Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
    Arch Dis Child 88:379-83. 2003
    ..To compare the convalescent antibody response to invasive Haemophilus influenzae type b (Hib) disease between conjugate vaccine immunised and unimmunised children, to look for evidence of priming for immunologic memory...
  63. pmc Elastase/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A
    Shyamala Ganesan
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109 0688, USA
    Am J Pathol 180:61-72. 2012
    ..These data validate the suitability of elastase/LPS model for investigating NTHi pathogenesis and progression of disease in COPD...
  64. ncbi Nontypeable Haemophilus influenzae invasive disease in The Netherlands: a retrospective surveillance study 2001-2008
    Karen van Wessel
    Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Infect Dis 53:e1-7. 2011
    ..The epidemiology, the course of disease, and the outcome of ntHi invasive disease are not well established. For prevention, risk groups that might benefit from vaccination have to be defined...
  65. ncbi Aerobic growth deficient Haemophilus influenzae mutants are non-virulent: implications on metabolism
    Mark Herbert
    Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Int J Med Microbiol 293:145-52. 2003
    ....
  66. ncbi Invasive Haemophilus influenzae disease: changing epidemiology and host-parasite interactions in the 21st century
    Marina Ulanova
    Division of Medical Sciences, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada
    Infect Genet Evol 9:594-605. 2009
    ..Developing new vaccines against non-type b H. influenzae is a potential solution to protect some vulnerable populations against the invasive disease...
  67. pmc Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis
    Yang Wang
    State Key Laboratory of Agricultural Microbiology, Division of Animal Infectious Disease, Huazhong Agricultural University, Wuhan, Hubei, China
    BMC Genomics 13:68. 2012
    ..Systematical analysis on host innate immune response to the infection is important for understanding the pathogenesis of the infectious microorganisms...
  68. pmc Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom
    J McVernon
    Population Biology of Infectious Disease Group, Department of Zoology, University of Oxford, UK
    Epidemiol Infect 136:800-12. 2008
    ..The contribution of herd immunity to disease control was reinforced. Possible intervention strategies will be explored in subsequent work...
  69. pmc Nontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates
    Pau Martí-Lliteras
    Programa de Infección e Inmunidad, Fundación Caubet CIMERA, Bunyola, Spain
    PLoS ONE 6:e21133. 2011
    ..6% of isolates. Such a genetic profile was associated with a higher bacterial resistance to serum mediated killing and enhanced adherence to human respiratory epithelial cells...
  70. ncbi Haemophilus influenzae and Haemophilus haemolyticus in tonsillar cultures of adults with acute pharyngotonsillitis
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama, 640 8501, Japan
    Auris Nasus Larynx 37:594-600. 2010
    ..The aim of this study was to evaluate the clinical implication of Haemophilus haemolyticus, one of the closest relative of Haemophilus influenzae, on acute pharyngotonsillitis...
  71. pmc Differential involvement of toll-like receptors 2 and 4 in the host response to acute respiratory infections with wild-type and mutant Haemophilus influenzae strains
    Eva Lorenz
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 73:2075-82. 2005
    ..influenzae can favor signaling through non-TLR4 receptors, such as TLR2. The results also indicate a close interaction between TLR4 and TLR2 that tightly regulates the expression of both receptors...
  72. pmc Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae
    Shigeki Nakamura
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1001247. 2011
    ....
  73. pmc Application of capillary electrophoresis mass spectrometry and liquid chromatography multiple-step tandem electrospray mass spectrometry to profile glycoform expression during Haemophilus influenzae pathogenesis in the chinchilla model of experimental oti
    Susanna L Lundström
    Karolinska Institutet and University College of South Stockholm, Clinical Research Center, Novum, S 141 86 Huddinge, Sweden
    Infect Immun 76:3255-67. 2008
    ..As previously observed, sialic acid-containing glycoforms were detected during the early stages of infection, but a trend toward more-truncated and less-complex LPS glycoforms that lacked sialic acid was found as disease progressed...
  74. ncbi Invasive disease caused by Haemophilus influenzae type a in Northern Ontario First Nations communities
    Len Kelly
    Northern Ontario School of Medicine, Thunder Bay and Sioux Lookout, Ontario, Canada
    J Med Microbiol 60:384-90. 2011
    ..Our data along with some published studies by others suggest an increased susceptibility to this infection among North American indigenous populations...
  75. ncbi Formation of biofilm by Haemophilus influenzae isolated from pediatric intractable otitis media
    Satomi Moriyama
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Japan
    Auris Nasus Larynx 36:525-31. 2009
    ..The aims of this study are to evaluate biofilm formation by nontypeable Haemophilus influenzae (NTHi) isolated from children with acute otitis media (AOM) and its relation with clinical outcome of the disease...
  76. ncbi Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage
    Roman Prymula
    Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Vaccine 29:1959-67. 2011
    ..Primary and booster vaccination with PHiD-CV reduced NPC of VT in the second year of life and tended to slightly increase that of NVT in line with previous experience with the 7-valent PCV...
  77. pmc Nasopharyngeal carriage of Haemophilus haemolyticus in otitis-prone and healthy children
    Lea Ann S Kirkham
    School of Paediatrics and Child Health, The University of Western Australia, Subiaco, Western Australia, Australia
    J Clin Microbiol 48:2557-9. 2010
    ..7% were H. haemolyticus and 9.4% gave equivocal results. Children with rAOM were more likely to carry H. haemolyticus...
  78. ncbi lgtC expression modulates resistance to C4b deposition on an invasive nontypeable Haemophilus influenzae
    Derek K Ho
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 178:1002-12. 2007
    ..Alteration of surface glycans of NTHi may be a critical event in determining the ability of a strain to evade host defenses and cause disseminated infection...
  79. pmc CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice
    Anke Leichtle
    Division of Otolaryngology, Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 184:3087-97. 2010
    ..Manipulation of CCL3 and/or TNF may prove to be effective therapeutic approaches in OM or other conditions associated with defective TNF generation...
  80. ncbi Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1
    Alicia L Humlicek
    Univ of Iowa Carver College of Medicine, Dept of Internal Medicine, C33 GH, 200 Hawkins Dr, Iowa City, IA 52242 1081, USA
    Am J Physiol Lung Cell Mol Physiol 287:L598-607. 2004
    ..The results indicate that epithelial cell ICAM-1 participates in neutrophil recruitment into the airway, but its most important role in clearance of H. influenzae may be assistance with neutrophil-dependent bacterial killing...
  81. pmc Association of IS1016 with the hia adhesin gene and biotypes V and I in invasive nontypeable Haemophilus influenzae
    Sarah W Satola
    Atlanta Veterans Affairs Medical Center and Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Infect Immun 76:5221-7. 2008
    ..IS1016-positive NTHI strains may represent a unique subset of NTHI strains, with characteristics more closely resembling those of encapsulated H. influenzae...
  82. pmc The descriptive epidemiology of Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal carriage in children and adults in Kilifi district, Kenya
    Osman Abdullahi
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatr Infect Dis J 27:59-64. 2008
    ..In East Africa we do not know how these pathogens are transmitted between population subgroups nor which serotypes circulate commonly...
  83. pmc Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates
    Laura A Novotny
    The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis and The Ohio State University College of Medicine, 700 Children s Drive, W591, Columbus, OH 43205, United States
    Vaccine 28:279-89. 2009
    ..Incorporating protective epitopes derived from two NTHI adhesins/virulence determinants into a single pediatric vaccine candidate to prevent OM has multiple potential inherent advantages...
  84. ncbi Role of nontypeable Haemophilus influenzae in exacerbations and progression of chronic obstructive pulmonary disease
    Nader Eldika
    Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University at Buffalo SUNY, New York, USA
    Curr Opin Pulm Med 12:118-24. 2006
    ..Application of modern understanding of bacterial pathogenesis and of innovative research methodologies, however, has considerably clarified its role...
  85. ncbi Characterization of invasive Haemophilus influenzae disease in Manitoba, Canada, 2000-2006: invasive disease due to non-type b strains
    Raymond S W Tsang
    Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Clin Infect Dis 44:1611-4. 2007
    ..influenzae disease was found to be approaching the rates of H. influenzae type b disease that were documented in the prevaccine period. Fifty-six percent of invasive disease now occurs in individuals aged >10 years...
  86. ncbi Haemophilus influenzae biofilms: hypothesis or fact?
    E Richard Moxon
    University of Oxford Department of Paediatrics, Oxford OX3 9DS, UK
    Trends Microbiol 16:95-100. 2008
    ..Uncritical acceptance of a distinctive NTHi biofilm phenotype has the potential to mislead and could confuse and compromise research efforts aimed at improving management and prevention of NTHi diseases of the human respiratory tract...
  87. ncbi Update on the diagnosis of Haemophilus parasuis infection in pigs and novel genotyping methods
    Alex Olvera
    Centre de Recerca en Sanitat Animal CReSA, Campus de Bellaterra, Universitat Autonoma de Barcelona, Barcelona, Spain
    Vet J 174:522-9. 2007
    ..parasuis strains. The association between genotype and virulence in H. parasuis is challenging due to the lack of knowledge of the complete genomic sequence and virulence factors of this bacterium...
  88. ncbi Protein D of Haemophilus influenzae: a protective nontypeable H. influenzae antigen and a carrier for pneumococcal conjugate vaccines
    Arne Forsgren
    Medical Microbiology, Department of Laboratory Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Clin Infect Dis 46:726-31. 2008
    ..influenzae. This may have great clinical implications, because PD is the first NT H. influenzae antigen that has induced protective responses in humans...
  89. ncbi Mixed community-acquired pneumonia in hospitalised patients
    A de Roux
    Servei de Pneumologia i Allergia Respiratoria, Institut Clinic del Torax, Facultad de Medicina, Universitat de Barcelona, and Servei de Malalties Infeccioses, Hospital Clinic i Provincial de Barcelona, Spain
    Eur Respir J 27:795-800. 2006
    ..In conclusion, mixed pneumonia occurs in >10% of cases with community-acquired pneumonia requiring hospitalisation...
  90. pmc TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media
    Anke Leichtle
    Department of Surgery Otolaryngology, University of California San Diego, La Jolla, California 92093, USA
    Innate Immun 15:205-15. 2009
    ..influenzae-induced otitis media. Toll-like receptor-4 signalling appears to induce TLR2 expression, and TLR2 activation is critical for bacterial clearance and timely resolution of otitis media...
  91. ncbi Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis
    V Bandi
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Respir Crit Care Med 164:2114-9. 2001
    ..This observation suggests a role for intracellular infection by NTHi in the pathogenesis of exacerbations of CB...
  92. pmc Identification of new genetic regions more prevalent in nontypeable Haemophilus influenzae otitis media strains than in throat strains
    Jingping Xie
    Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109 2029, USA
    J Clin Microbiol 44:4316-25. 2006
    ..Classification tree analysis of lic2B, hmwA, and the nine new potential otitis media virulence genes revealed two H. influenzae pathotypes associated with otitis media...
  93. ncbi Bacterial infections--a major cause of death among children in Africa
    E Kim Mulholland
    N Engl J Med 352:75-7. 2005
  94. pmc Myeloid differentiation primary response gene 88 is required for the resolution of otitis media
    Michelle Hernandez
    Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, and Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    J Infect Dis 198:1862-9. 2008
    ....
  95. ncbi Haemophilus influenzae and the complement system
    Teresia Hallström
    Medical Microbiology, Department of Laboratory Medicine Malmö, Lund University, Skane University Hospital, SE 205 02 Malmo, Sweden
    Trends Microbiol 18:258-65. 2010
    ..Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system...
  96. pmc Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx
    Jennelle M Kyd
    Division of Science and Design, Gadi Research Centre, University of Canberra, Canberra, Australia
    Infect Immun 71:4691-9. 2003
    ..influenzae...
  97. ncbi Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung
    Xiaorong Wang
    Institute for Human Gene Therapy, Department of Molecular and Cellular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:810-5. 2002
    ..influenzae in the lung. This suggests that the airway epithelia might contribute to sensing of H. influenzae infection and signaling the innate immune response...
  98. pmc Binding of complement regulators to invasive nontypeable Haemophilus influenzae isolates is not increased compared to nasopharyngeal isolates, but serum resistance is linked to disease severity
    Teresia Hallström
    Medical Microbiology, Department of Laboratory Medicine, University Hospital Malmo, Lund University, SE 205 02 Malmo, Sweden
    J Clin Microbiol 48:921-7. 2010
    ..The ability to resist the attack of the complement system seems to be important for NTHi strains infecting the respiratory tract as well as the bloodstream...
  99. ncbi Peptide and recombinant antigens for protection against bacterial middle ear infection
    L O Bakaletz
    The Ohio State University College of Medicine and Public Health, Department of Pediatrics, Division of Molecular Medicine, Children s Research Institute, Columbus, OH 43205 2696, USA
    Vaccine 19:2323-8. 2001
    ..Both immunogens thus remain strong vaccine candidates...
  100. pmc Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B
    Feng Xu
    Department of Respiratory Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China
    Respir Res 9:16. 2008
    ....
  101. pmc Prevalence and distribution of adhesins in invasive non-type b encapsulated Haemophilus influenzae
    Carina A Rodriguez
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Infect Immun 71:1635-42. 2003
    ..Although the specific complement of adhesin genes in non-type b encapsulated H. influenzae varies, most invasive strains express Hap and Hia, suggesting these adhesins may be especially important to the virulence of these organisms...

Research Grants50

  1. Supporting New Faculty Recruitment Through Biomedical Research Core Center
    David H Ingbar; Fiscal Year: 2010
    ..Dr Williams's research brings an innovative approach to understanding and decreasing Pseudomonas infection in CF patients. ..
  2. Recurrent otitis media and COPD: immunity and vaccines
    Timothy Murphy; Fiscal Year: 2004
    ..The proposed studies will advance the field of vaccine development to prevent otitis media and respiratory tract infections in COPD. ..
  3. DEVELOPMENT OF A VACCINE FOR MORAXELLA CATARRHALIS
    Timothy Murphy; Fiscal Year: 2009
    ..catarrhalis surface, the identification of surface antigens expressed specifically during human infection and critical information about the human immune response to surface antigens of M. catarrhalis. ..
  4. BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESIS
    Jeffrey Weiser; Fiscal Year: 2009
    ..Aim 3 will determine the effects of the immune response to ChoP on colonization, where our findings demonstrate that expression of ChoP is most important to pathogenesis. ..
  5. Competition Among Bacterial Resiratory Pathogens
    Jeffrey Weiser; Fiscal Year: 2004
    ..Future strategies to decrease disease burden by reducing carriage could result from a greater understanding of interactions between species. ..
  6. RSV Inhibition of Interferon-Dependent Airway Immunity
    Dwight Look; Fiscal Year: 2007
    ..abstract_text> ..
  7. NICHD Institutional Training for Pediatricians
    Kathryn Edwards; Fiscal Year: 2007
    ..3.) Evaluate the success of the training program through both process and outcomes evaluation. (4.) Implement continuous quality improvement procedures that will enhance the PPOR components, curriculum, and overall program. ..
  8. Pneumococcal Biofilms in Otitis Media
    James Post; Fiscal Year: 2007
    ..Delineating the molecular basis of biofilms will not only advance our understanding of OM, but of chronic infectious disease in general. ..
  9. Training in Patient-Oriented Research for Physicians
    Eugene Shapiro; Fiscal Year: 2006
    ..Ultimately, the Yale CRS Program will help to increase the pool of physician-investigators who will be uniquely poised to conduct research to directly improve the health of all Americans. [unreadable] [unreadable] [unreadable]..
  10. Effectiveness of Varicella Vaccine in Clinical Practice
    Eugene Shapiro; Fiscal Year: 2006
    ..abstract_text> ..
  11. Appropriate Pneumococcal Vaccination in Infants in Fiji
    EDWARD MULHOLLAND; Fiscal Year: 2005
    ..This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. ..
  12. Pilot Study of Automated Surveillance to Measure Burden
    Paul Kilgore; Fiscal Year: 2007
    ..We will assess the potential use of the phone/web-based case reporting system for measuring the impact of health interventions including vaccines. [unreadable] [unreadable] [unreadable]..
  13. Protein Glycosylatin in Haemophilus ducreyi
    Robert Munson; Fiscal Year: 2007
    ..ducreyi infection. [unreadable] [unreadable] [unreadable]..
  14. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  15. Immunoglobulin Allotypes in Hepatitis C Virus Infection
    JANARDAN PANDEY; Fiscal Year: 2008
    ..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
  16. Bacterial host mimicry and chronic airway infection
    WILLIAM SWORDS; Fiscal Year: 2009
    ..Therefore, this project offers an important opportunity to develop new ways to combat chronic airway infections that are a major cause of morbidity and mortality worldwide. ..
  17. ASM Conference on Pasteurellaceae
    WILLIAM SWORDS; Fiscal Year: 2008
    ..Thus, this meeting bridges multiple disciplines to provide opportunity for exchange and development of ideas. [unreadable] [unreadable] [unreadable]..
  18. Polysaccharide Antibody Repertoires
    Alexander H Lucas; Fiscal Year: 2010
    ..This research will deepen our understanding of the human immune system and may contribute toward the design of better vaccines. ..
  19. Biofilm formation by Neisseria gonorrhoeae
    Michael A Apicella; Fiscal Year: 2010
    ..This will be accomplished by studying the subproteomes of the cytoplasmic fraction, inner and outer membranes. ..
  20. Induction of COPD Exacerbation by Haemophilus influenzae
    Dwight Look; Fiscal Year: 2009
    ..Expression of important bacterial factors will be identified and linked to epithelial cell adherence and responses. ..
  21. In-Home Prevention of SA risks in Native Teen Families
    John T Walkup; Fiscal Year: 2010
    ....
  22. Funds to acquire a JEOL JSM-7401F FESEM
    Michael Apicella; Fiscal Year: 2006
    ..Wilson examines Leismania compromised human macrophages. Starner will study the relationship of Haemophilus biofilms to infection and inflammation in Cystic Fibrosis patients. [unreadable] [unreadable]..
  23. Pasteurellaceae 2005
    Robert Munson; Fiscal Year: 2005
    ..These 2 activities will assure that all of our conference goals are met. ..
  24. Segregation of H.i nfluenzae LPS genes in otitis media
    KIRK MCCREA; Fiscal Year: 2006
    ..AIM I. Determine the distribution of LOS genes among NT H. influenzae middle ear and throat isolates. AIM II. Identify LOS gene variations and determine their distributions among middle ear and throat isolates. ..
  25. VACCINE TRIALS USING INDIVIDUAL AND ECOLOGICAL UNITS
    JAMES KOOPMAN; Fiscal Year: 2002
    ..They will also provide insight regarding how different biological effects of vaccines generate different population effects of vaccine programs. ..
  26. Genomic Sequence of an Otitis Media Isolate of NTHi
    Robert Munson; Fiscal Year: 2003
    ..We propose to close and annotate the genome of nontypeable H. influenzae strain 86-028. ..
  27. Social and psychological risk for infectious illness
    Sheldon A Cohen; Fiscal Year: 2010
    ..abstract_text> ..
  28. Tenth Annual Midwest Microbial Pathogenesis Conference
    Michael Apicella; Fiscal Year: 2003
    ..Such interdisciplinary collaborations have fostered open dialogues and it is expected that the Tenth Annual Midwest Microbial Pathogenesis Conference will continue in this tradition. ..
  29. Library on a Chip: Bacterial Strain Microarray
    Lixin Zhang; Fiscal Year: 2004
    ..Create full-scale library chips for genetic screening A. Print a chip each with a library of genomic DNA from 1024 E. coli strains B. Test applications using bacterial library array chips ..
  30. THE EFFECTIVENESS OF VACCINES IN CLINICAL PRACTICE
    Eugene Shapiro; Fiscal Year: 2004
    ..Shapiro to review their progress and to help them develop their own studies as well as to develop strategies for the development of their careers. ..
  31. MOLECULAR GENETICS OF A SYNDROME WITH HEARING IMPAIRMENT
    J Post; Fiscal Year: 2004
    ..The delineation of the panoply of genes involved in causing craniosynostosis will enhance our understanding of these diseases and suggest new therapeutic strategies. ..
  32. FOURTEENTH INTERNATIONAL PATHOGENIC NEISSERIA CONFERENCE
    Michael Apicella; Fiscal Year: 2004
    ..6. To develop new research agenda for the study of the pathogenic Neisseria and to recommend new and future research initiatives and prioritize these. ..
  33. Pharmacodynamics in Antifungal Resistance
    David Andes; Fiscal Year: 2005
    ..The candidate's goal is to integrate knowledge of antifungal PD and the acquisition of approaches and skills in molecular biology through the completion of this grant. ..
  34. Molecular basis meningococcal group A capsular immunity
    Dan Granoff; Fiscal Year: 2007
    ..abstract_text> ..
  35. EPITHELIAL CELL RESPONSE TO H.INFLUENZAE IN THE AIRWAY
    Dwight Look; Fiscal Year: 2003
    ..The functions of ICAM-1 will be determined by examining ICAM-1 expression, leukocyte recruitment and function, and bacteria clearance under conditions that allow for manipulation of airway defense factors. ..
  36. Nontypeable Haemophilus influenzae & host cell signaling
    WILLIAM SWORDS; Fiscal Year: 2003
    ..abstract_text> ..
  37. CONSTRUCTION OF THE VACCINE CENTER
    ALEXANDER LUCAS; Fiscal Year: 2002
    ..Construction of the CIVD will expand investigators' research capabilities, promote programmatic interaction and growth, increase training opportunities, and permit recruitment of additional scientists. ..
  38. MOLECULAR EPIDEMIOLOGIC APPROACHES TO UTI GENE DISCOVERY
    Carl Marrs; Fiscal Year: 2004
    ..The investigators state that the discovery of additional factors involved in E. coli mediated UTI will facilitate the development of new strategies for the prevention and cure of UTI. ..
  39. Genotypes of Helicobacter Pylori in West Africa
    Richard Adegbola; Fiscal Year: 2005
    ..pylori colonization in West Africa differ from those seen in industrialized nations, and enable the development of appropriate treatment strategies for communities such as The Gambia. ..
  40. MODIFICATION OF ICAM 1 EXPRESSION IN LUNG EPITHELIUM
    Dwight Look; Fiscal Year: 2001
    ..The selectivity and biochemical basis for Ad5 inhibition of IFN-dependent ICAM-1 expression will be investigated by examining components of the IFN-driven pathway leading to Stat1-dependent ICAM-1 expression. ..
  41. Neisseria meningitidis antigens expressed in infection
    Dan Granoff; Fiscal Year: 2005
    ..meningitidis disease, including group B strains for which there is currently no vaccine available. Also, characterization of gene expression in an in vivo model will lead to a better understanding of meningococcal pathogenesis. ..
  42. Regulation of gtf Gene Expression in S mutans
    Steven Goodman; Fiscal Year: 2005
    ..Since these gtf genes are involved in the colonization process, the genetic elements that are found here will need to be examined in terms of the bacteria's pathogenic mechanisms. ..
  43. Molecular epidemiologic identification of pneumococcal tissue specific genes
    MELINDA MARY PETTIGREW; Fiscal Year: 2010
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..
  44. Forensic Detection of Salmonella Resistance and Subtype
    Lee Harrison; Fiscal Year: 2005
    ..enterica and 2) molecular methods for rapid outbreak detection among S. enterica serovars. ..
  45. Genetic of Papilloma-induced Voice Distrubance
    Farrel Buchinsky; Fiscal Year: 2007
    ..The latest genomic advances enable one to discover the underlying genetic susceptibilities to infectious agents. Collaborations have been established to obtain and analyze the specimens necessary for such a mission. ..
  46. Cranberry Juice and Urinary Tract Infections
    Cibele Barbosa Cesnik; Fiscal Year: 2007
    ..We will also be able to evaluate if the bacterial population in the vagina, periurethra and stool is different after regularly drinking cranberry juice compared to placebo. ..
  47. Gene Discovery for Pneumococcal Otitis Media
    Melinda Pettigrew; Fiscal Year: 2005
    ..Discovery of additional factors involved in streptococcal OM will facilitate the development of new strategies for the control and prevention of this important disease. ..