Genomes and Genes
Summary: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications292 found, 100 shown here
- Helicobacter pylori infection and the development of gastric cancerN Uemura
Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
N Engl J Med 345:784-9. 2001..Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain...
- Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus ReportPeter Malfertheiner
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
Gut 61:646-64. 2012..Recommendations are provided on the basis of the best current evidence and plausibility to guide doctors involved in the management of this infection associated with various clinical conditions...
- American College of Gastroenterology guideline on the management of Helicobacter pylori infectionWilliam D Chey
University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Am J Gastroenterol 102:1808-25. 2007..Recent data suggest that a PPI, levofloxacin, and amoxicillin for 10 days is more effective and better tolerated than bismuth quadruple therapy for persistent H. pylori infection, though this needs to be validated in the United States...
- Helicobacter pylori and gastrointestinal tract adenocarcinomasRichard M Peek
Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
Nat Rev Cancer 2:28-37. 2002....
- An African origin for the intimate association between humans and Helicobacter pyloriBodo Linz
Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
Nature 445:915-8. 2007..pylori before their migrations from Africa and demonstrate that H. pylori has remained intimately associated with their human host populations ever since...
- Pathogenesis of Helicobacter pylori infectionJohannes G Kusters
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Clin Microbiol Rev 19:449-90. 2006..This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori...
- Interleukin-1 polymorphisms associated with increased risk of gastric cancerE M El-Omar
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nature 404:398-402. 2000..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not...
- Epidemiology of gastric cancerKatherine D Crew
Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, New York, NY 10032, United States
World J Gastroenterol 12:354-62. 2006..The purpose of this review is to examine the epidemiology and risk factors of gastric cancer, and to discuss strategies for primary prevention...
- Gastric cancer originating from bone marrow-derived cellsJeanMarie Houghton
Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 306:1568-71. 2004..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
- Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cellsIsabella M Toller
Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 108:14944-9. 2011..pylori and with its mutagenic properties in vitro and in vivo and may contribute to the genetic instability and frequent chromosomal aberrations that are a hallmark of gastric cancer...
- Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trialKazutoshi Fukase
Department of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan
Lancet 372:392-7. 2008..Our aim was to investigate the prophylactic effect of H pylori eradication on the development of metachronous gastric carcinoma after endoscopic resection for early gastric cancer...
- Helicobacter pylori: gastric cancer and beyondD Brent Polk
Department of Pediatrics, University of Southern California, Los Angeles, CA 10027, USA
Nat Rev Cancer 10:403-14. 2010..pylori-infected human populations at increased risk for stomach cancer but will also provide mechanistic insights into inflammatory carcinomas that develop beyond the gastric niche...
- Helicobacter pylori: epidemiology and routes of transmissionL M Brown
Biostatistics Branch, Division of Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza South, Room 8026, MSC 7244, Bethesda, MD 20892 7244, USA
Epidemiol Rev 22:283-97. 2000..pylori is important to prevent its spread and may be useful in identifying high-risk populations, especially in areas that have high rates of gastric lymphoma, gastric cancer, and gastric ulcer...
- Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?Lorenzo Fuccio
University of Bologna, Bologna, Italy
Ann Intern Med 151:121-8. 2009..Helicobacter pylori infection is associated with gastric cancer, but the effect of eradication treatment on gastric cancer risk is not well defined...
- Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trialBenjamin Chun Yu Wong
Department of Medicine, University of Hong Kong, Hong Kong, China
JAMA 291:187-94. 2004..Although chronic Helicobacter pylori infection is associated with gastric cancer, the effect of H pylori treatment on prevention of gastric cancer development in chronic carriers is unknown...
- Microevolution of Helicobacter pylori during prolonged infection of single hosts and within familiesGiovanna Morelli
Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
PLoS Genet 6:e1001036. 2010..Comparisons with the recent literature show that short-term mutation rates vary dramatically in different bacterial species and can span a range of several orders of magnitude...
- Helicobacter pylori infectionSebastian Suerbaum
Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
N Engl J Med 347:1175-86. 2002
- Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphismsEmad M El-Omar
Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
Gastroenterology 124:1193-201. 2003..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
- The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in KoreaJung Mook Kang
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
J Clin Gastroenterol 43:420-8. 2009..The present study was performed to evaluate whether or not the genetic polymorphisms of IL-6, IL-8, and IL-10 are associated with gastroduodenal disease in the Korean population...
- Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonizationLaura K Sycuro
Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
Cell 141:822-33. 2010..Our findings suggest that the coordinated action of multiple proteins relaxes peptidoglycan crosslinking, enabling helical cell curvature and twist...
- Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interfaceCarrie L Shaffer
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS Pathog 7:e1002237. 2011..In summary, these results indicate that CagH, CagI, and CagL are components of a T4SS subassembly involved in pilus biogenesis, and highlight the important role played by unique constituents of the H. pylori cag T4SS...
- Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in miceShuiping Tu
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cancer Cell 14:408-19. 2008..These results demonstrate that pathologic elevation of a single proinflammatory cytokine may be sufficient to induce neoplasia and provide a direct link between IL-1beta, MDSCs, and carcinogenesis...
- What a disorder: proinflammatory signaling pathways induced by Helicobacter pyloriSteffen Backert
University College Dublin, School of Biomolecular and Biomedical Sciences, Belfield Campus, Dublin 4, Ireland
Trends Microbiol 18:479-86. 2010..Here we discuss the pros and cons of the multiple signaling activities in the induction of proinflammatory responses and associated problems, and give suggestions for finding ways out of this dilemma...
- CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivoRoland Rad
Second Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
Gastroenterology 131:525-37. 2006..It is unclear why the immune system is unable to eliminate the infection, but recent studies suggested that CD4+/CD25+/Foxp3+ regulatory T cells may be involved in this process...
- Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus ReportP Malfertheiner
Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Zentrum fur Innere Medizin, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Gut 56:772-81. 2007..Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000...
- Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infectionK Ming Fock
Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore 529889
J Gastroenterol Hepatol 24:1587-600. 2009..Both CYP2C19 genetic polymorphisms and cigarette smoking can influence future H. pylori eradication rates...
- Control of gut differentiation and intestinal-type gastric carcinogenesisYasuhito Yuasa
Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Nat Rev Cancer 3:592-600. 2003..Inappropriate activation of intestine-specific transcription factors could contribute to the occurrence of the intestinal-type cancer of the stomach...
- Coadaptation of Helicobacter pylori and humans: ancient history, modern implicationsJohn C Atherton
Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
J Clin Invest 119:2475-87. 2009..These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases...
- Helicobacter pylori in health and diseaseTimothy L Cover
Department of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA
Gastroenterology 136:1863-73. 2009....
- Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytesWafa Khamri
Immunoregulation Laboratory, Department of Nephrology and Transplantation, 5th Floor Thomas Guy House, Guy s Hospital Campus, King s College London School of Medicine at Guy s, London SE1 9RT, United Kingdom
Infect Immun 78:845-53. 2010..Altogether, we can conclude that DCs are potent inducers of IL-23/IL-17 expression following H. pylori stimulation. IL-1/IL-23 as well as H. pylori virulence factors seem to play an important role in mediating this response...
- Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesionBenjamin Hoy
Junior Research Group, Paul Ehrlich Institute, Langen, Germany
EMBO Rep 11:798-804. 2010..pylori designed to access the intercellular space. We then designed a small-molecule inhibitor that efficiently blocks HtrA activity, E-cadherin cleavage and intercellular entry of H. pylori...
- Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complexTobias Wiedemann
Ludwig Maximilians University Munich, Munich, Germany
Gut 61:986-96. 2012..H pylori induced hypergastrinaemia is described as being a major risk factor for the development of gastric adenocarcinoma...
- Helicobacter pylori persistence: biology and diseaseMartin J Blaser
Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA
J Clin Invest 113:321-33. 2004..A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia...
- Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancerYuji Maehata
Department of Medicine and Clinical Science, Kyushu University, Fukuoka, Japan
Gastrointest Endosc 75:39-46. 2012..A prospective, randomized trial proved that Helicobacter pylori eradication significantly reduces the incidence of metachronous gastric cancer during a 3-year follow-up...
- Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory responseBin Xiao
Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, No 30 Gaotanyan Street, Chongqing, China
J Infect Dis 200:916-25. 2009..H. pylori is a major human pathogenic bacterium in gastric mucosa. To date, the role of miRNAs in response to H. pylori infection has not been explored...
- Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatmentNadim S Jafri
University of Louisville, Louisville, Kentucky 40202, USA
Ann Intern Med 148:923-31. 2008..Standard proton-pump inhibitor-based therapy for Helicobacter pylori infection fails in up to one quarter of patients. Sequential therapy may be more efficacious...
- Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesionsWei Cheng You
Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China
J Natl Cancer Inst 98:974-83. 2006..We conducted a randomized trial to test the effects of one-time H. pylori treatment and long-term vitamin or garlic supplements in reducing the prevalence of advanced precancerous gastric lesions...
- The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseasesJohn C Atherton
Wolfson Digestive Diseases Centre and Institute of Infections, Immunity, and Inflammation, University of Nottingham, Nottingham NG7 2UH, United Kingdom
Annu Rev Pathol 1:63-96. 2006..pylori in developed countries has led to a falling incidence of associated diseases. However, whether there are disadvantages of an H. pylori-free stomach, for example increased risk of esosphageal adenocarcinoma, remains unclear...
- Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cellsIsabelle C Arnold
Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
J Clin Invest 121:3088-93. 2011..Our results thus provide experimental evidence for a beneficial effect of H. pylori colonization on the development of allergen-induced asthma...
- Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised editionMasahiro Asaka
Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Helicobacter 15:1-20. 2010..pylori and gastric cancer has been demonstrated more clearly. Accordingly, the committee of the Japanese Society for Helicobacter Research has revised the guidelines for diagnosis and treatment of H. pylori infection in Japan...
- Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesisNicole Tegtmeyer
School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, University College Dublin, Dublin, Ireland
FEBS J 278:1190-202. 2011..The contribution of these signalling pathways to pathogenesis during H. pylori infections is discussed...
- Helicobacter pylori treatment in the era of increasing antibiotic resistanceDavid Y Graham
Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Gut 59:1143-53. 2010..Treatments needing further evaluation include those containing furazolidone or nitazoxanide, hybrids of sequential-concomitant therapies and amoxicillin-PPI dual therapy with PPI doses such that they maintain intragastric pH >6...
- Nature meets nurture: molecular genetics of gastric cancerAnya N Milne
Pathology Department H04 2 25, University Medical Centre Utrecht, Postbus 85500, 3508GA Utrecht, The Netherlands
Hum Genet 126:615-28. 2009..The role of E-cadherin in the nature (genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed...
- Helicobacter pylori and gastric cancer: factors that modulate disease riskLydia E Wroblewski
Division of Gastroenterology, Vanderbilt University School of Medicine, 2215 Garland Ave, 1030C MRB IV, Nashville, TN 37232 2279, USA
Clin Microbiol Rev 23:713-39. 2010..Since H. pylori inhibits the gastric epithelium of half of the world, it is crucial that we continue to gain understanding of host and microbial factors that increase the risk of developing more severe clinical outcomes...
- NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathwayTomohiro Watanabe
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 120:1645-62. 2010..pylori and possibly other mucosal infections...
- Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus ReportP Malfertheiner
Center for Internal Medicine, Clinic of Gastroenterology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Aliment Pharmacol Ther 16:167-80. 2002..Successful eradication should always be confirmed by urea breath test or an endoscopy-based test if endoscopy is clinically indicated. Stool antigen test is the alternative if urea breath test is not available...
- Oncogenic mechanisms of the Helicobacter pylori CagA proteinMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
Nat Rev Cancer 4:688-94. 2004..Intriguingly, CagA is noted for its variation, particularly at the SHP2-binding site, which could affect the potential of different strains of H. pylori to promote gastric carcinogenesis...
- Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphismsDaniela Basso
Department of Laboratory Medicine, University of Padova, Padova, Italy
Gastroenterology 135:91-9. 2008..We assessed the association of new and established cagA and vacA polymorphisms with disease...
- Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagAM Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Oncogene 27:7047-54. 2008..These findings indicate that loss of cell polarity underlies the abnormal proliferation of epithelial cells that directs carcinogenesis...
- Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese populationHong mei Zeng
Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China
Cancer Epidemiol Biomarkers Prev 20:2594-602. 2011..To screen the genetic variants of TLR2 and TLR5, and evaluate their associations with gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shandong Province, China...
- Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasiaJennifer L Lofgren
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Gastroenterology 140:210-20. 2011..We determined if germfree INS-GAS mice spontaneously develop GIN and if H pylori accelerates GIN in gnotobiotic INS-GAS mice...
- [Diagnosis and treatment guidelines for Helicobacter pylori infection in Korea]Nayoung Kim
Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Seoul, Korea
Korean J Gastroenterol 54:269-78. 2009..Herein, Korean College of Helicobacter and Upper Gastrointestinal Research proposes a diagnostic and treatment guideline based on currently available evidence...
- Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literatureElena Lionetti
Department of Paediatrics, University of Catania, Catania, Italy
Helicobacter 15:79-87. 2010....
- A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursorsGeorgina L Hold
Department of Medicine and Therapeutics, Aberdeen University, Aberdeen, Scotland
Gastroenterology 132:905-12. 2007..The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis...
- c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strainsDoreen Mueller
University of Magdeburg, Department of Medical Microbiology, Magdeburg, Germany
J Clin Invest 122:1553-66. 2012..These results provide insight for clinical H. pylori typing and clarify the role of phosphorylated bacterial effector proteins in pathogenesis...
- Helicobacter pylori and gastric cancer:current status of the Austrain Czech German gastric cancer prevention trial (PRISMA Study)S Miehlke
Medical Department I, Technical University Hospital Carl Gustav Carus, Fetscherstrabetae 74, D 01307 Dresden, Germany
World J Gastroenterol 7:243-7. 2001..pylori gastritis appears to be more common than expected. Further follow up and continuing recruitment are necessary to fulfil the main aim of the study...
- Host response to Helicobacter pylori infection before initiation of the adaptive immune responseHolly M Scott Algood
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
FEMS Immunol Med Microbiol 51:577-86. 2007..It is speculated that inappropriate waning of the innate immune response during early stages of infection may be a factor that contributes to H. pylori persistence...
- Polymorphisms in Toll-like receptor genes and risk of cancerE M El-Omar
Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK
Oncogene 27:244-52. 2008..In this review, we discuss polymorphisms in Toll-like receptors and give an insight into how they may influence risk of cancer...
- Epidemiology of Helicobacter pylori infection and public health implicationsKhean Lee Goh
Department of Medicine Gastroenterology and Hepatology, University of Malaya, Kuala Lumpur, Malaysia
Helicobacter 16:1-9. 2011..pylori eradication as a gastric cancer-prevention strategy has now been further emphasized in Japanese guidelines. Two studies have shown a decrease in the burden of dyspepsia and peptic ulcer disease with H. pylori eradication...
- Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 miceArlin B Rogers
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cancer Res 65:10709-15. 2005..In summary, we report for the first time H. pylori-induced gastric intraepithelial neoplasia in a wild-type mouse model and show no additive effect of high-salt ingestion on tumor progression...
- Sequential and concomitant therapy with four drugs is equally effective for eradication of H pylori infectionDeng Chyang Wu
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Clin Gastroenterol Hepatol 8:36-41.e1. 2010..We compared the efficacies of sequential and concomitant therapy and analyzed the effects of antibiotic resistance in patients with H pylori infection...
- Helicobacter pylori and gastric carcinogenesisMasanori Hatakeyama
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 0815, Japan
J Gastroenterol 44:239-48. 2009..Ectopically expressed AID may contribute to H. pylori-initiated gastric carcinogenesis by increasing the risk of likelihood of epithelial cells acquiring mutations in cancer-related genes...
- Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strainsC Figueiredo
IPATIMUP and Faculty of Medicine, University of Porto, Gastroenterology Dept, Hospital Sto António, Portugal
Scand J Gastroenterol 36:128-35. 2001..Clinical outcome of Helicobacter pylori infection is associated with virulence-associated bacterial genotypes. This study assessed the relationships between vacA, cagA and iceA genotypes and gastric diseases in Portuguese patients...
- Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomachS A Bleuming
Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands, and Department of Gastroenterology and Hepatology, Geneva University Hospital, Switzerland
J Pathol 209:190-7. 2006..The data suggest that morphological changes in epithelial histology may result from alterations in the morphogenetic landscape secondary to changes in the cellular composition of the lamina propria...
- Sequential therapy for Helicobacter pylori eradication: a critical reviewJavier P Gisbert
Department of Gastroenterology, Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain
J Clin Gastroenterol 44:313-25. 2010..Alternative treatment regimens for standard triple therapy are urgently needed...
- Seroprevalence of Helicobacter pylori in South KoreaJeong Yoon Yim
Healthcare System Gangnam Center, Healthcare Research Institute, Seoul National University Hospital, Seoul, Korea
Helicobacter 12:333-40. 2007..The aims of this study were to investigate the interval change of seropositivity of H. pylori between 1998 and 2005 in Korean adult population and to find the factors related to H. pylori infection...
- Inflammation, atrophy, and gastric cancerJames G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Clin Invest 117:60-9. 2007..We also discuss how the increased understanding of the relationship between inflammation and gastric cancer still leaves many questions unanswered regarding recommendations for prevention and treatment...
- Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesinMarina Aspholm-Hurtig
Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
Science 305:519-22. 2004....
- Helicobacter pylori gastritis in children is associated with a regulatory T-cell responsePaul R Harris
Department of Pediatrics, Pontificia Universidad Católica de Chile and Hospital Dr Sótero del Río, Santiago, Chile
Gastroenterology 134:491-9. 2008....
- Traces of human migrations in Helicobacter pylori populationsDaniel Falush
Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, 10117 Berlin, Germany
Science 299:1582-5. 2003..Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade...
- CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient miceSusan E Erdman
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Am J Pathol 162:691-702. 2003..These roles for T cells in protection against colon carcinoma may have implications for new modes of prevention and treatment of cancer in humans...
- Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancerMark S McClain
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
BMC Genomics 10:3. 2009..In this study, we analyzed the genome sequences of an H. pylori strain (98-10) isolated from a patient with gastric cancer and an H. pylori strain (B128) isolated from a patient with gastric ulcer disease...
- A report card to grade Helicobacter pylori therapyDavid Y Graham
Helicobacter 12:275-8. 2007..In most regions legacy triple therapy should be abandoned as unacceptable. Quadruple therapy and sequential therapy are reasonable alternatives for initial therapy...
- Role of type IV secretion in Helicobacter pylori pathogenesisSteffen Backert
Otto von Guericke Universitat Magdeburg, Institut fur Medizinische Mikrobiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Cell Microbiol 10:1573-81. 2008..The contribution of these signalling cascades to H. pylori pathogenesis is discussed...
- Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infectionB Schmausser
Institut fur Pathologie, Universitat Wurzburg, Wuerzburg, Germany
Clin Exp Immunol 136:521-6. 2004..pylori infection. This polarized and dynamically regulated gastric epithelial expression of TLRs supports a sentinel role for these receptors in the mucosal immunity to H. pylori...
- Cellular and molecular aspects of gastric cancerMalcolm G Smith
Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
World J Gastroenterol 12:2979-90. 2006..In this review, we examine the molecular and cellular events that underlie H pylori-induced gastric cancer...
- Effects of interleukin-10 polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancerJeongseon Kim
Cancer Epidemiology Branch, National Cancer Center, Goyang, Korea
PLoS ONE 7:e29643. 2012..Therefore, we investigated the associations between IL10 polymorphisms, Helicobacter pylori (H. pylori) infection, and smoking in noncardia gastric carcinogenesis in Koreans...
- Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer diseaseChun Ying Wu
Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan
Gastroenterology 137:1641-8.e1-2. 2009..Helicobacter pylori (H pylori) is a risk factor for gastric cancer. We investigated whether early H pylori eradication is associated with gastric cancer risk in patients with peptic ulcer diseases...
- Epidemiology of Helicobacter pylori infection and public health implicationsAlexander C Ford
Centre for Digestive Diseases, Leeds General Infirmary, Great George Street, Leeds, UK
Helicobacter 15:1-6. 2010..As yet, no country has adopted public health measures to treat infected individuals or prevent infection in populations at risk...
- Host-bacterial interactions in Helicobacter pylori infectionManuel R Amieva
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Gastroenterology 134:306-23. 2008..This review offers an insight into H pylori host-bacterial interactions...
- Optimal therapy for Helicobacter pylori infectionsEmiko Rimbara
Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Nat Rev Gastroenterol Hepatol 8:79-88. 2011..Standard triple therapy (a PPI, amoxicillin and clarithromycin) should now be avoided owing to increasing resistance to this treatment...
- Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analysesChristina Persson
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Am J Epidemiol 173:259-70. 2011..pylori infection, and country of origin. Study quality considerations, both laboratory and epidemiologic, can also affect results and may explain, in part, the variability in results published to date...
- 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trialE Robert Greenberg
SWOG Statistical Center, Cancer Research and Biostatistics, Seattle, WA 98101 1468, USA
Lancet 378:507-14. 2011..We therefore did a randomised trial in Latin America comparing the effectiveness of four-drug regimens given concomitantly or sequentially with that of a standard 14-day regimen of triple therapy...
- Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trialPeter Malfertheiner
Gastroenterologie, Hepatologie und Infektiologie, Otto von Guericke Universtität, Magdeburg, Germany
Lancet 377:905-13. 2011..Our aim was to assess the efficacy and safety of a new, single-capsule treatment versus the gold standard for H pylori eradication...
- Epidemiological link between gastric disease and polymorphisms in VacA and CagASungil Jang
Department of Oral Biology, Oral Science Research Center, BK21 Project, Yonsei University College of Dentistry, Seoul, South Korea
J Clin Microbiol 48:559-67. 2010..011). In this South Korean population, the majority of H. pylori strains carry the vacA s1/i1/m1 allele and the CagA EPIYA-ABD allele. These facts may contribute to the high incidence of gastric maladies, including gastric cancer...
- Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatmentH Szajewska
Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland
Aliment Pharmacol Ther 32:1069-79. 2010..Problems with currently recommended Helicobacter pylori eradication therapies include unsatisfactory eradication rates and/or therapy-associated side effects...
- Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatusWolfgang Fischer
Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munchen, Germany
FEBS J 278:1203-12. 2011..This review describes the molecular properties of the Cag-T4SS and compares these with prototypical systems of this family of protein transporters...
- Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortalityJun Ling Ma
Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China
J Natl Cancer Inst 104:488-92. 2012..Vitamin treatment was associated with statistically significantly fewer deaths from gastric or esophageal cancer, a secondary endpoint (HR = 0.51, 95% CI = 0.30 to 0.87; P = .014)...
- Geographic map and evolution of primary Helicobacter pylori resistance to antibacterial agentsLyudmila Boyanova
Department of Medical Microbiology, Medical University of Sofia, Zdrave Street 2, 1431 Sofia, Bulgaria
Expert Rev Anti Infect Ther 8:59-70. 2010....
- Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritisJunichi Kawashima
Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda Tsujido Machi, Kawagoe, Saitama 350 8550, Japan
J Gastroenterol 44:1046-54. 2009..We attempted to clarify the significance of atrophic change of gastric mucosa for reduction of plasma ghrelin concentration irrespective of Helicobacter pylori (Hp) infection...
- Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammationRamazan Gen
Department of Endocrinology and Metabolism, Region Education and Research Hospital, Erzurum, Turkey
South Med J 103:190-6. 2010..The aim of this study was to investigate the effects of HP eradication on insulin resistance, serum lipids and low-grade inflammation...
- Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosaF Luzza
Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Catanzaro, Italy
J Immunol 165:5332-7. 2000..Together, these data indicate that biologically active IL-17 production is increased during HP: infection, suggesting the possibility that this cytokine may play an important role in the inflammatory response to the HP colonization...
- Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in miceJohn Y Kao
Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
Gastroenterology 138:1046-54. 2010..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
- Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infectionIl Ran Hwang
Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 123:1793-803. 2002....
- Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7Yinfei Yin
Division of Pre Clinical Oncology, University of Nottingham, Nottingham, UK
Gut 59:1037-45. 2010....
- Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defensesHolly M Scott Algood
Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Clin Microbiol Rev 19:597-613. 2006..pylori resists immune clearance and also are relevant for understanding the pathogenesis of diseases caused by H. pylori (peptic ulcer disease, gastric adenocarcinoma, and gastric lymphoma)...
- Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylory isolatesDana J Philpott
Unité de Pathogénie Microbienne Moléculaire INSERM U389, 28 rue du Dr Roux, Paris 75724, France
Cell Microbiol 4:285-96. 2002..This work provides evidence for in vivo selection of H. pylori bacteria with a reduced capacity to induce inflammatory responses and suggests that such bacteria are better adapted to colonize mice...
- The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer riskAyca Sayi
Institute of Molecular Cancer Research and
J Immunol 182:7085-101. 2009..In summary, our data suggest a dual role for IFN-gamma in Helicobacter pathogenesis that could be the basis for the differential susceptibility to H. pylori-induced gastric pathology in the human population...
- Long term follow up of patients treated for Helicobacter pylori infectionR Mera
Department of Pathology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
Gut 54:1536-40. 2005..Understanding long term effects resulting from the cure of this infection is needed to design cancer prevention strategies...
- CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesionsL A Sicinschi
Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Clin Microbiol Infect 16:369-78. 2010..This novel finding may partially explain the difference in GC incidence in these populations...
- Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle?Henry J Windle
School of Medicine, Trinity College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland
Pediatrics 119:e754-9. 2007..The consequent synergistic impact of diarrheal disease and micronutrient deficiency on growth and cognitive function in children has significant public health implications for socioeconomic development in these countries...
- Inhibition of pathogen-induced NFkBmediated inflammationRichard Peek; Fiscal Year: 2005..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
- PATHOGENESIS OF HELICOBACTER HEPATICUSCATHERINE BECKWITH; Fiscal Year: 2007..assays, identification of virulence factors, and characterization of the pathogenesis of rodent Helicobacter infections. With the SERCA, Dr...
- Helicobacter hepaticus induced typhlitisMATTHEW MYLES; Fiscal Year: 2007..Their combined expertise in the fields of rodent Helicobacter infections, host-pathogen interactions, animal model development, DNA array technology and analysis, cellular ..
- CHOLERA TOXIN--A MUCOSAL ADJUVANT, MECHANISMS & IMMUNITYJohn Nedrud; Fiscal Year: 1999..Sendai virus infects the respiratory tract and is a murine parainfluenza virus. Helicobacter infections of gastric tissue have been implicated as causes of gastroduodenal ulcers and gastric cancer.
- INTERACTIONS OF HELICOBACTER WITH THE GASTRIC MUCOSADonald Guiney; Fiscal Year: 2001..the role of NO, prostaglandin E2, and cytokines in mediating both mucosal protection and damage during Helicobacter infections. We have preliminary data indicating that H...
- THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASEDavid Graham; Fiscal Year: 2005..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
- HELICOBACTER INFECTION AND GROWTH OF CHILDRENPelayo Correa; Fiscal Year: 2001..pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies. ..
- HUS Pathogenesis & clinical Outcome in an in vivo modelJames Fox; Fiscal Year: 2008..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
- Immunoepidemiology of Concomittant InfectionSharon Perry; Fiscal Year: 2008..S. foreign born and the developing world. ..
- Microecology-murine gut-initiation & progression of IBDJames Fox; Fiscal Year: 2005..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESJames Fox; Fiscal Year: 2006....
- Mechanism that regulate Helicobacter pylori-induced beta-caterin activationRichard Peek; Fiscal Year: 2009..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
- IN VIVO PATHOGENESIS OF HELICOBACTER PYLORIJames Fox; Fiscal Year: 2009..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
- H.pylori Effects on DNA Repair in Gastric EpitheliumAntonia Sepulveda; Fiscal Year: 2008..Knowledge gained from this study is likely to support the indication for Hp eradication in H. pylori-infected patients to prevent GC. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASEGeorge Sachs; Fiscal Year: 2005..Hence this approach will provide additional insights into mechanisms of regulation of gastric secretion and enable illuminated interpretation of the pathophysiology of peptic ulcer disease. ..
- Immunological Basis for H. Pylori-Related MalignanciesMarygorret Obonyo; Fiscal Year: 2006..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
- Helicobacter induced hepatitis and tumorigenesisJames Fox; Fiscal Year: 2009..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
- THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENTGeorge Sachs; Fiscal Year: 2009..The results of the proposed research will further improve the agents used for the treatment of acid-related diseases and also our knowledge of the ATPase and cellular events involved in regulation of its activity. ..
- H. PYLORI-SPECIFIC REGULATORY T CELLS THAT LIMIT HOST RESPONSEThomas Blanchard; Fiscal Year: 2008..These studies will increase our understanding of gastrointestinal immunoregulation and the design of better immunotherapies. ..
- FUNCTION AND REGULATION OF GASTRINTimothy Wang; Fiscal Year: 2008..Overall, these studies will attempt to define the role of progastrin-derived peptides in stem cell regulation and in bridging genetic pathways in colorectal cancer. ..
- Development of a vaccine against Helicobacter pylori to prevent gastric cancerRODOLFO BEGUE; Fiscal Year: 2008..pylori vaccine. And, prevention of H. pylori infection should eventually lead to elimination of its associated complications, including gastric cancer. [unreadable] [unreadable] [unreadable]..
- H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESISFritz Francois; Fiscal Year: 2008..From these studies, both the microbial contribution and the host genotype contribution to adenocarcinoma risk should be able to be assessed, as well as to begin to define relevant cellular pathways. ..
- Enteric flora modulates the development of colitisAlbert Jergens; Fiscal Year: 2008..g., graduate students and postdoctoral fellow). There are ample opportunities to attend seminars, journal clubs and work-in-progress research meetings during which the applicant can become engaged in scientific discussions. ..
- Case-Control Study of Pancreas Cancer Etiologic FactorsHarvey Risch; Fiscal Year: 2008..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
- METHYLATION PROFILING AND RISK OF COLORECTAL CANCERHassan Ashktorab; Fiscal Year: 2007..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..
- Under the Skin: Understanding the Role of Stress and Immune Function in Health DiJENNIFER DOWD; Fiscal Year: 2009..We will test whether these immune and infection markers are related to psychosocial and economic stressors and whether they mediate the relationship between SES and health outcomes including mortality. ..
- Inhibition of Fas-apoptosis in Gastric CancerJeanMarie Houghton; Fiscal Year: 2010..These studies will provide critical insight into novel preventive, and anti-cancer strategies aimed at restoring Fas sensitivity within tumor cells and provide a new direction for cancer treatment. ..
- Epidemiology and Incidence of Barrett's EsophagusDOUGLAS ALLEN CORLEY; Fiscal Year: 2010..The proposed study explores how hormones associated with body fat may change the way the body heals after an injury, and increase the risk of cells developing precancerous changes. ..
- Stem Cells and Gastric CancerTIMOTHY CRAGIN WANG; Fiscal Year: 2010....
- Host and Bacterial Factors in Disease due to H. pyloriKathryn A Eaton; Fiscal Year: 2010..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..
- Mechanisms of Immune Modulation by Abscisic AcidJosep Bassaganya Riera; Fiscal Year: 2010..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
- Inhibitors to Clostridium perfrigens epsilon toxinMARK MCCLAIN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- iNOS, COX-2, and Arginase in Murine Barrett's EsophagusKeith Wilson; Fiscal Year: 2003..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs. iNOS -/-mice, and C. WT vs. argll -/- mice. ..
- THERAPY FOR GASTROINTESTINAL DISORDERSElizabeth Dial; Fiscal Year: 2002..Development of this therapeutic potential for rhLF will fulfill a crucial need for a way to safely administer NSAIDs. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Role of Fas/NF kB in H.pylori induced gastric carcinomaJeanMarie Houghton; Fiscal Year: 2003..Defining the regulation of these pathways will help define the complex relationship helicobacter shares with its host. ..
- CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCEMartin Blaser; Fiscal Year: 2004..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
- H PYLORI RECOMBINATION AND GASTRIC COLONIZATIONMartin Blaser; Fiscal Year: 2001..pylori infections. ..
- Immune response to Helicobacter pylori VacA as a markerGuillermo Perez Perez; Fiscal Year: 2004..If our hypothesis is correct, we hope to establish a simple and economical serological test to assess the risk of gastric cancer development. ..
- Recombinant murine IL-10 produced in situ by H. pyloriKATHRYN EATON; Fiscal Year: 2005..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
- Genetics of Turner Syndrome Neurocognitive PhenotypeAndrew Zinn; Fiscal Year: 2006..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
- Probiotic Modulation/Dendritic Cells in Experimental IBDMaureen Drakes; Fiscal Year: 2006..Findings from these studies will provide a better understanding of the therapeutic mechanisms of probiotics in inflammatory bowel disease. ..
- CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIAChaim Hershko; Fiscal Year: 2001..abstract_text> ..
- Mechanisms of H pylori-Induced HypochlorhydriaAdam Smolka; Fiscal Year: 2008..pylori strain identity, and anatomic site of infection. These studies will establish the mechanistic basis of H. pylori-induced gastric hypochlorhydria, and add to the understanding of H. pylori pathophysiology. ..
- 14th International Symposium on Regulatory PeptidesTimothy Wang; Fiscal Year: 2002..abstract_text> ..
- NEUROENDOCRINE MEDIATION OF E. COLI 0157:H7 INFECTIONMark Lyte; Fiscal Year: 2003..The demonstration of direct neuroendocrine-bacterial interaction as a mechanism in the pathogenesis of E. coli O157:H7 infection may yield new treatments for both the prevention and treatment of hemorrhagic colitis. ..
- Anatomic and Mechanical Variables of the EGJ in GERDJohn Pandolfino; Fiscal Year: 2006..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
- Development of furanones for treatment of anthraxMartin Blaser; Fiscal Year: 2005..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
- H. Pylory factors associated with peptic ulcer diseaseTIMOTHY COVER; Fiscal Year: 2006..pylori factors that help to determine clinical outcome, and ultimately, may lead to advances in the treatment or prevention of H. pylori-associated human diseases. [unreadable] [unreadable]..
- Surrogate Biomarkers of Micrometastatic Gastric CancerAdam Smolka; Fiscal Year: 2004..The successful development and validation of a lymph node RT-PCR-based assay for micrometastatic stomach cancer is likely to have a significant clinical impact. ..
- Mechanisms of Growth Inhibition by Helicobacter PylorHassan Ashktorab; Fiscal Year: 2003..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
- Gut to Brain Pathways for Infection-Induced AnxietyMark Lyte; Fiscal Year: 2005..abstract_text> ..
- DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDYHarvey Risch; Fiscal Year: 2002..abstract_text> ..
- CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGYHarvey Risch; Fiscal Year: 2002....