helicobacter infections

Summary

Summary: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

Articles from Journal RESEARCH

Top Publications

  1. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
  2. ncbi Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Gut 61:646-64. 2012
  3. ncbi American College of Gastroenterology guideline on the management of Helicobacter pylori infection
    William D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 102:1808-25. 2007
  4. ncbi Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
  5. pmc An African origin for the intimate association between humans and Helicobacter pylori
    Bodo Linz
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Nature 445:915-8. 2007
  6. pmc Pathogenesis of Helicobacter pylori infection
    Johannes G Kusters
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Rev 19:449-90. 2006
  7. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
  8. pmc Epidemiology of gastric cancer
    Katherine D Crew
    Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, New York, NY 10032, United States
    World J Gastroenterol 12:354-62. 2006
  9. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
  10. pmc Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells
    Isabella M Toller
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:14944-9. 2011

Research Grants

Detail Information

Articles from Journal RESEARCH1

Publications292 found, 100 shown here

  1. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
    ..Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain...
  2. ncbi Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Gut 61:646-64. 2012
    ..Recommendations are provided on the basis of the best current evidence and plausibility to guide doctors involved in the management of this infection associated with various clinical conditions...
  3. ncbi American College of Gastroenterology guideline on the management of Helicobacter pylori infection
    William D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 102:1808-25. 2007
    ..Recent data suggest that a PPI, levofloxacin, and amoxicillin for 10 days is more effective and better tolerated than bismuth quadruple therapy for persistent H. pylori infection, though this needs to be validated in the United States...
  4. ncbi Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
    ....
  5. pmc An African origin for the intimate association between humans and Helicobacter pylori
    Bodo Linz
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Nature 445:915-8. 2007
    ..pylori before their migrations from Africa and demonstrate that H. pylori has remained intimately associated with their human host populations ever since...
  6. pmc Pathogenesis of Helicobacter pylori infection
    Johannes G Kusters
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Rev 19:449-90. 2006
    ..This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori...
  7. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
    ..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not...
  8. pmc Epidemiology of gastric cancer
    Katherine D Crew
    Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, New York, NY 10032, United States
    World J Gastroenterol 12:354-62. 2006
    ..The purpose of this review is to examine the epidemiology and risk factors of gastric cancer, and to discuss strategies for primary prevention...
  9. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  10. pmc Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells
    Isabella M Toller
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:14944-9. 2011
    ..pylori and with its mutagenic properties in vitro and in vivo and may contribute to the genetic instability and frequent chromosomal aberrations that are a hallmark of gastric cancer...
  11. ncbi Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial
    Kazutoshi Fukase
    Department of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Lancet 372:392-7. 2008
    ..Our aim was to investigate the prophylactic effect of H pylori eradication on the development of metachronous gastric carcinoma after endoscopic resection for early gastric cancer...
  12. pmc Helicobacter pylori: gastric cancer and beyond
    D Brent Polk
    Department of Pediatrics, University of Southern California, Los Angeles, CA 10027, USA
    Nat Rev Cancer 10:403-14. 2010
    ..pylori-infected human populations at increased risk for stomach cancer but will also provide mechanistic insights into inflammatory carcinomas that develop beyond the gastric niche...
  13. ncbi Helicobacter pylori: epidemiology and routes of transmission
    L M Brown
    Biostatistics Branch, Division of Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Executive Plaza South, Room 8026, MSC 7244, Bethesda, MD 20892 7244, USA
    Epidemiol Rev 22:283-97. 2000
    ..pylori is important to prevent its spread and may be useful in identifying high-risk populations, especially in areas that have high rates of gastric lymphoma, gastric cancer, and gastric ulcer...
  14. ncbi Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?
    Lorenzo Fuccio
    University of Bologna, Bologna, Italy
    Ann Intern Med 151:121-8. 2009
    ..Helicobacter pylori infection is associated with gastric cancer, but the effect of eradication treatment on gastric cancer risk is not well defined...
  15. ncbi Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial
    Benjamin Chun Yu Wong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    JAMA 291:187-94. 2004
    ..Although chronic Helicobacter pylori infection is associated with gastric cancer, the effect of H pylori treatment on prevention of gastric cancer development in chronic carriers is unknown...
  16. pmc Microevolution of Helicobacter pylori during prolonged infection of single hosts and within families
    Giovanna Morelli
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS Genet 6:e1001036. 2010
    ..Comparisons with the recent literature show that short-term mutation rates vary dramatically in different bacterial species and can span a range of several orders of magnitude...
  17. ncbi Helicobacter pylori infection
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 347:1175-86. 2002
  18. ncbi Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
    ..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
  19. ncbi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
    ..The present study was performed to evaluate whether or not the genetic polymorphisms of IL-6, IL-8, and IL-10 are associated with gastroduodenal disease in the Korean population...
  20. pmc Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization
    Laura K Sycuro
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell 141:822-33. 2010
    ..Our findings suggest that the coordinated action of multiple proteins relaxes peptidoglycan crosslinking, enabling helical cell curvature and twist...
  21. pmc Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface
    Carrie L Shaffer
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Pathog 7:e1002237. 2011
    ..In summary, these results indicate that CagH, CagI, and CagL are components of a T4SS subassembly involved in pilus biogenesis, and highlight the important role played by unique constituents of the H. pylori cag T4SS...
  22. pmc Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
    Shuiping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cancer Cell 14:408-19. 2008
    ..These results demonstrate that pathologic elevation of a single proinflammatory cytokine may be sufficient to induce neoplasia and provide a direct link between IL-1beta, MDSCs, and carcinogenesis...
  23. ncbi What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori
    Steffen Backert
    University College Dublin, School of Biomolecular and Biomedical Sciences, Belfield Campus, Dublin 4, Ireland
    Trends Microbiol 18:479-86. 2010
    ..Here we discuss the pros and cons of the multiple signaling activities in the induction of proinflammatory responses and associated problems, and give suggestions for finding ways out of this dilemma...
  24. ncbi CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo
    Roland Rad
    Second Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
    Gastroenterology 131:525-37. 2006
    ..It is unclear why the immune system is unable to eliminate the infection, but recent studies suggested that CD4+/CD25+/Foxp3+ regulatory T cells may be involved in this process...
  25. pmc Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
    P Malfertheiner
    Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Zentrum fur Innere Medizin, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Gut 56:772-81. 2007
    ..Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000...
  26. ncbi Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection
    K Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore 529889
    J Gastroenterol Hepatol 24:1587-600. 2009
    ..Both CYP2C19 genetic polymorphisms and cigarette smoking can influence future H. pylori eradication rates...
  27. ncbi Control of gut differentiation and intestinal-type gastric carcinogenesis
    Yasuhito Yuasa
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Cancer 3:592-600. 2003
    ..Inappropriate activation of intestine-specific transcription factors could contribute to the occurrence of the intestinal-type cancer of the stomach...
  28. pmc Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
    John C Atherton
    Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
    J Clin Invest 119:2475-87. 2009
    ..These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases...
  29. pmc Helicobacter pylori in health and disease
    Timothy L Cover
    Department of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA
    Gastroenterology 136:1863-73. 2009
    ....
  30. pmc Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes
    Wafa Khamri
    Immunoregulation Laboratory, Department of Nephrology and Transplantation, 5th Floor Thomas Guy House, Guy s Hospital Campus, King s College London School of Medicine at Guy s, London SE1 9RT, United Kingdom
    Infect Immun 78:845-53. 2010
    ..Altogether, we can conclude that DCs are potent inducers of IL-23/IL-17 expression following H. pylori stimulation. IL-1/IL-23 as well as H. pylori virulence factors seem to play an important role in mediating this response...
  31. pmc Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion
    Benjamin Hoy
    Junior Research Group, Paul Ehrlich Institute, Langen, Germany
    EMBO Rep 11:798-804. 2010
    ..pylori designed to access the intercellular space. We then designed a small-molecule inhibitor that efficiently blocks HtrA activity, E-cadherin cleavage and intercellular entry of H. pylori...
  32. ncbi Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex
    Tobias Wiedemann
    Ludwig Maximilians University Munich, Munich, Germany
    Gut 61:986-96. 2012
    ..H pylori induced hypergastrinaemia is described as being a major risk factor for the development of gastric adenocarcinoma...
  33. pmc Helicobacter pylori persistence: biology and disease
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA
    J Clin Invest 113:321-33. 2004
    ..A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia...
  34. ncbi Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer
    Yuji Maehata
    Department of Medicine and Clinical Science, Kyushu University, Fukuoka, Japan
    Gastrointest Endosc 75:39-46. 2012
    ..A prospective, randomized trial proved that Helicobacter pylori eradication significantly reduces the incidence of metachronous gastric cancer during a 3-year follow-up...
  35. ncbi Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response
    Bin Xiao
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, No 30 Gaotanyan Street, Chongqing, China
    J Infect Dis 200:916-25. 2009
    ..H. pylori is a major human pathogenic bacterium in gastric mucosa. To date, the role of miRNAs in response to H. pylori infection has not been explored...
  36. ncbi Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatment
    Nadim S Jafri
    University of Louisville, Louisville, Kentucky 40202, USA
    Ann Intern Med 148:923-31. 2008
    ..Standard proton-pump inhibitor-based therapy for Helicobacter pylori infection fails in up to one quarter of patients. Sequential therapy may be more efficacious...
  37. ncbi Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions
    Wei Cheng You
    Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China
    J Natl Cancer Inst 98:974-83. 2006
    ..We conducted a randomized trial to test the effects of one-time H. pylori treatment and long-term vitamin or garlic supplements in reducing the prevalence of advanced precancerous gastric lesions...
  38. ncbi The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases
    John C Atherton
    Wolfson Digestive Diseases Centre and Institute of Infections, Immunity, and Inflammation, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Annu Rev Pathol 1:63-96. 2006
    ..pylori in developed countries has led to a falling incidence of associated diseases. However, whether there are disadvantages of an H. pylori-free stomach, for example increased risk of esosphageal adenocarcinoma, remains unclear...
  39. pmc Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells
    Isabelle C Arnold
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    J Clin Invest 121:3088-93. 2011
    ..Our results thus provide experimental evidence for a beneficial effect of H. pylori colonization on the development of allergen-induced asthma...
  40. ncbi Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition
    Masahiro Asaka
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Helicobacter 15:1-20. 2010
    ..pylori and gastric cancer has been demonstrated more clearly. Accordingly, the committee of the Japanese Society for Helicobacter Research has revised the guidelines for diagnosis and treatment of H. pylori infection in Japan...
  41. pmc Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis
    Nicole Tegtmeyer
    School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, University College Dublin, Dublin, Ireland
    FEBS J 278:1190-202. 2011
    ..The contribution of these signalling pathways to pathogenesis during H. pylori infections is discussed...
  42. ncbi Helicobacter pylori treatment in the era of increasing antibiotic resistance
    David Y Graham
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gut 59:1143-53. 2010
    ..Treatments needing further evaluation include those containing furazolidone or nitazoxanide, hybrids of sequential-concomitant therapies and amoxicillin-PPI dual therapy with PPI doses such that they maintain intragastric pH >6...
  43. pmc Nature meets nurture: molecular genetics of gastric cancer
    Anya N Milne
    Pathology Department H04 2 25, University Medical Centre Utrecht, Postbus 85500, 3508GA Utrecht, The Netherlands
    Hum Genet 126:615-28. 2009
    ..The role of E-cadherin in the nature (genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed...
  44. pmc Helicobacter pylori and gastric cancer: factors that modulate disease risk
    Lydia E Wroblewski
    Division of Gastroenterology, Vanderbilt University School of Medicine, 2215 Garland Ave, 1030C MRB IV, Nashville, TN 37232 2279, USA
    Clin Microbiol Rev 23:713-39. 2010
    ..Since H. pylori inhibits the gastric epithelium of half of the world, it is crucial that we continue to gain understanding of host and microbial factors that increase the risk of developing more severe clinical outcomes...
  45. pmc NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:1645-62. 2010
    ..pylori and possibly other mucosal infections...
  46. ncbi Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report
    P Malfertheiner
    Center for Internal Medicine, Clinic of Gastroenterology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Aliment Pharmacol Ther 16:167-80. 2002
    ..Successful eradication should always be confirmed by urea breath test or an endoscopy-based test if endoscopy is clinically indicated. Stool antigen test is the alternative if urea breath test is not available...
  47. ncbi Oncogenic mechanisms of the Helicobacter pylori CagA protein
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060 0815, Japan
    Nat Rev Cancer 4:688-94. 2004
    ..Intriguingly, CagA is noted for its variation, particularly at the SHP2-binding site, which could affect the potential of different strains of H. pylori to promote gastric carcinogenesis...
  48. ncbi Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    Daniela Basso
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Gastroenterology 135:91-9. 2008
    ..We assessed the association of new and established cagA and vacA polymorphisms with disease...
  49. ncbi Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA
    M Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 27:7047-54. 2008
    ..These findings indicate that loss of cell polarity underlies the abnormal proliferation of epithelial cells that directs carcinogenesis...
  50. ncbi Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese population
    Hong mei Zeng
    Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China
    Cancer Epidemiol Biomarkers Prev 20:2594-602. 2011
    ..To screen the genetic variants of TLR2 and TLR5, and evaluate their associations with gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shandong Province, China...
  51. pmc Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia
    Jennifer L Lofgren
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Gastroenterology 140:210-20. 2011
    ..We determined if germfree INS-GAS mice spontaneously develop GIN and if H pylori accelerates GIN in gnotobiotic INS-GAS mice...
  52. ncbi [Diagnosis and treatment guidelines for Helicobacter pylori infection in Korea]
    Nayoung Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Seoul, Korea
    Korean J Gastroenterol 54:269-78. 2009
    ..Herein, Korean College of Helicobacter and Upper Gastrointestinal Research proposes a diagnostic and treatment guideline based on currently available evidence...
  53. ncbi Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature
    Elena Lionetti
    Department of Paediatrics, University of Catania, Catania, Italy
    Helicobacter 15:79-87. 2010
    ....
  54. ncbi A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors
    Georgina L Hold
    Department of Medicine and Therapeutics, Aberdeen University, Aberdeen, Scotland
    Gastroenterology 132:905-12. 2007
    ..The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis...
  55. pmc c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains
    Doreen Mueller
    University of Magdeburg, Department of Medical Microbiology, Magdeburg, Germany
    J Clin Invest 122:1553-66. 2012
    ..These results provide insight for clinical H. pylori typing and clarify the role of phosphorylated bacterial effector proteins in pathogenesis...
  56. ncbi Helicobacter pylori and gastric cancer:current status of the Austrain Czech German gastric cancer prevention trial (PRISMA Study)
    S Miehlke
    Medical Department I, Technical University Hospital Carl Gustav Carus, Fetscherstrabetae 74, D 01307 Dresden, Germany
    World J Gastroenterol 7:243-7. 2001
    ..pylori gastritis appears to be more common than expected. Further follow up and continuing recruitment are necessary to fulfil the main aim of the study...
  57. ncbi Host response to Helicobacter pylori infection before initiation of the adaptive immune response
    Holly M Scott Algood
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEMS Immunol Med Microbiol 51:577-86. 2007
    ..It is speculated that inappropriate waning of the innate immune response during early stages of infection may be a factor that contributes to H. pylori persistence...
  58. ncbi Polymorphisms in Toll-like receptor genes and risk of cancer
    E M El-Omar
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK
    Oncogene 27:244-52. 2008
    ..In this review, we discuss polymorphisms in Toll-like receptors and give an insight into how they may influence risk of cancer...
  59. pmc Epidemiology of Helicobacter pylori infection and public health implications
    Khean Lee Goh
    Department of Medicine Gastroenterology and Hepatology, University of Malaya, Kuala Lumpur, Malaysia
    Helicobacter 16:1-9. 2011
    ..pylori eradication as a gastric cancer-prevention strategy has now been further emphasized in Japanese guidelines. Two studies have shown a decrease in the burden of dyspepsia and peptic ulcer disease with H. pylori eradication...
  60. ncbi Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:10709-15. 2005
    ..In summary, we report for the first time H. pylori-induced gastric intraepithelial neoplasia in a wild-type mouse model and show no additive effect of high-salt ingestion on tumor progression...
  61. pmc Sequential and concomitant therapy with four drugs is equally effective for eradication of H pylori infection
    Deng Chyang Wu
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Clin Gastroenterol Hepatol 8:36-41.e1. 2010
    ..We compared the efficacies of sequential and concomitant therapy and analyzed the effects of antibiotic resistance in patients with H pylori infection...
  62. ncbi Helicobacter pylori and gastric carcinogenesis
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 0815, Japan
    J Gastroenterol 44:239-48. 2009
    ..Ectopically expressed AID may contribute to H. pylori-initiated gastric carcinogenesis by increasing the risk of likelihood of epithelial cells acquiring mutations in cancer-related genes...
  63. ncbi Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains
    C Figueiredo
    IPATIMUP and Faculty of Medicine, University of Porto, Gastroenterology Dept, Hospital Sto António, Portugal
    Scand J Gastroenterol 36:128-35. 2001
    ..Clinical outcome of Helicobacter pylori infection is associated with virulence-associated bacterial genotypes. This study assessed the relationships between vacA, cagA and iceA genotypes and gastric diseases in Portuguese patients...
  64. ncbi Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach
    S A Bleuming
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands, and Department of Gastroenterology and Hepatology, Geneva University Hospital, Switzerland
    J Pathol 209:190-7. 2006
    ..The data suggest that morphological changes in epithelial histology may result from alterations in the morphogenetic landscape secondary to changes in the cellular composition of the lamina propria...
  65. ncbi Sequential therapy for Helicobacter pylori eradication: a critical review
    Javier P Gisbert
    Department of Gastroenterology, Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain
    J Clin Gastroenterol 44:313-25. 2010
    ..Alternative treatment regimens for standard triple therapy are urgently needed...
  66. ncbi Seroprevalence of Helicobacter pylori in South Korea
    Jeong Yoon Yim
    Healthcare System Gangnam Center, Healthcare Research Institute, Seoul National University Hospital, Seoul, Korea
    Helicobacter 12:333-40. 2007
    ..The aims of this study were to investigate the interval change of seropositivity of H. pylori between 1998 and 2005 in Korean adult population and to find the factors related to H. pylori infection...
  67. pmc Inflammation, atrophy, and gastric cancer
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 117:60-9. 2007
    ..We also discuss how the increased understanding of the relationship between inflammation and gastric cancer still leaves many questions unanswered regarding recommendations for prevention and treatment...
  68. ncbi Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
    Marina Aspholm-Hurtig
    Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 305:519-22. 2004
    ....
  69. ncbi Helicobacter pylori gastritis in children is associated with a regulatory T-cell response
    Paul R Harris
    Department of Pediatrics, Pontificia Universidad Católica de Chile and Hospital Dr Sótero del Río, Santiago, Chile
    Gastroenterology 134:491-9. 2008
    ....
  70. ncbi Traces of human migrations in Helicobacter pylori populations
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, 10117 Berlin, Germany
    Science 299:1582-5. 2003
    ..Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade...
  71. pmc CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 162:691-702. 2003
    ..These roles for T cells in protection against colon carcinoma may have implications for new modes of prevention and treatment of cancer in humans...
  72. pmc Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    BMC Genomics 10:3. 2009
    ..In this study, we analyzed the genome sequences of an H. pylori strain (98-10) isolated from a patient with gastric cancer and an H. pylori strain (B128) isolated from a patient with gastric ulcer disease...
  73. ncbi A report card to grade Helicobacter pylori therapy
    David Y Graham
    Helicobacter 12:275-8. 2007
    ..In most regions legacy triple therapy should be abandoned as unacceptable. Quadruple therapy and sequential therapy are reasonable alternatives for initial therapy...
  74. ncbi Role of type IV secretion in Helicobacter pylori pathogenesis
    Steffen Backert
    Otto von Guericke Universitat Magdeburg, Institut fur Medizinische Mikrobiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Cell Microbiol 10:1573-81. 2008
    ..The contribution of these signalling cascades to H. pylori pathogenesis is discussed...
  75. pmc Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection
    B Schmausser
    Institut fur Pathologie, Universitat Wurzburg, Wuerzburg, Germany
    Clin Exp Immunol 136:521-6. 2004
    ..pylori infection. This polarized and dynamically regulated gastric epithelial expression of TLRs supports a sentinel role for these receptors in the mucosal immunity to H. pylori...
  76. pmc Cellular and molecular aspects of gastric cancer
    Malcolm G Smith
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
    World J Gastroenterol 12:2979-90. 2006
    ..In this review, we examine the molecular and cellular events that underlie H pylori-induced gastric cancer...
  77. pmc Effects of interleukin-10 polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer
    Jeongseon Kim
    Cancer Epidemiology Branch, National Cancer Center, Goyang, Korea
    PLoS ONE 7:e29643. 2012
    ..Therefore, we investigated the associations between IL10 polymorphisms, Helicobacter pylori (H. pylori) infection, and smoking in noncardia gastric carcinogenesis in Koreans...
  78. ncbi Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease
    Chun Ying Wu
    Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan
    Gastroenterology 137:1641-8.e1-2. 2009
    ..Helicobacter pylori (H pylori) is a risk factor for gastric cancer. We investigated whether early H pylori eradication is associated with gastric cancer risk in patients with peptic ulcer diseases...
  79. ncbi Epidemiology of Helicobacter pylori infection and public health implications
    Alexander C Ford
    Centre for Digestive Diseases, Leeds General Infirmary, Great George Street, Leeds, UK
    Helicobacter 15:1-6. 2010
    ..As yet, no country has adopted public health measures to treat infected individuals or prevent infection in populations at risk...
  80. ncbi Host-bacterial interactions in Helicobacter pylori infection
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 134:306-23. 2008
    ..This review offers an insight into H pylori host-bacterial interactions...
  81. ncbi Optimal therapy for Helicobacter pylori infections
    Emiko Rimbara
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Rev Gastroenterol Hepatol 8:79-88. 2011
    ..Standard triple therapy (a PPI, amoxicillin and clarithromycin) should now be avoided owing to increasing resistance to this treatment...
  82. pmc Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses
    Christina Persson
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Am J Epidemiol 173:259-70. 2011
    ..pylori infection, and country of origin. Study quality considerations, both laboratory and epidemiologic, can also affect results and may explain, in part, the variability in results published to date...
  83. pmc 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial
    E Robert Greenberg
    SWOG Statistical Center, Cancer Research and Biostatistics, Seattle, WA 98101 1468, USA
    Lancet 378:507-14. 2011
    ..We therefore did a randomised trial in Latin America comparing the effectiveness of four-drug regimens given concomitantly or sequentially with that of a standard 14-day regimen of triple therapy...
  84. ncbi Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial
    Peter Malfertheiner
    Gastroenterologie, Hepatologie und Infektiologie, Otto von Guericke Universtität, Magdeburg, Germany
    Lancet 377:905-13. 2011
    ..Our aim was to assess the efficacy and safety of a new, single-capsule treatment versus the gold standard for H pylori eradication...
  85. pmc Epidemiological link between gastric disease and polymorphisms in VacA and CagA
    Sungil Jang
    Department of Oral Biology, Oral Science Research Center, BK21 Project, Yonsei University College of Dentistry, Seoul, South Korea
    J Clin Microbiol 48:559-67. 2010
    ..011). In this South Korean population, the majority of H. pylori strains carry the vacA s1/i1/m1 allele and the CagA EPIYA-ABD allele. These facts may contribute to the high incidence of gastric maladies, including gastric cancer...
  86. ncbi Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment
    H Szajewska
    Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland
    Aliment Pharmacol Ther 32:1069-79. 2010
    ..Problems with currently recommended Helicobacter pylori eradication therapies include unsatisfactory eradication rates and/or therapy-associated side effects...
  87. ncbi Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus
    Wolfgang Fischer
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munchen, Germany
    FEBS J 278:1203-12. 2011
    ..This review describes the molecular properties of the Cag-T4SS and compares these with prototypical systems of this family of protein transporters...
  88. pmc Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality
    Jun Ling Ma
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China
    J Natl Cancer Inst 104:488-92. 2012
    ..Vitamin treatment was associated with statistically significantly fewer deaths from gastric or esophageal cancer, a secondary endpoint (HR = 0.51, 95% CI = 0.30 to 0.87; P = .014)...
  89. ncbi Geographic map and evolution of primary Helicobacter pylori resistance to antibacterial agents
    Lyudmila Boyanova
    Department of Medical Microbiology, Medical University of Sofia, Zdrave Street 2, 1431 Sofia, Bulgaria
    Expert Rev Anti Infect Ther 8:59-70. 2010
    ....
  90. ncbi Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis
    Junichi Kawashima
    Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda Tsujido Machi, Kawagoe, Saitama 350 8550, Japan
    J Gastroenterol 44:1046-54. 2009
    ..We attempted to clarify the significance of atrophic change of gastric mucosa for reduction of plasma ghrelin concentration irrespective of Helicobacter pylori (Hp) infection...
  91. ncbi Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation
    Ramazan Gen
    Department of Endocrinology and Metabolism, Region Education and Research Hospital, Erzurum, Turkey
    South Med J 103:190-6. 2010
    ..The aim of this study was to investigate the effects of HP eradication on insulin resistance, serum lipids and low-grade inflammation...
  92. ncbi Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa
    F Luzza
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Catanzaro, Italy
    J Immunol 165:5332-7. 2000
    ..Together, these data indicate that biologically active IL-17 production is increased during HP: infection, suggesting the possibility that this cytokine may play an important role in the inflammatory response to the HP colonization...
  93. pmc Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    John Y Kao
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
    Gastroenterology 138:1046-54. 2010
    ..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
  94. ncbi Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection
    Il Ran Hwang
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:1793-803. 2002
    ....
  95. pmc Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7
    Yinfei Yin
    Division of Pre Clinical Oncology, University of Nottingham, Nottingham, UK
    Gut 59:1037-45. 2010
    ....
  96. pmc Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses
    Holly M Scott Algood
    Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Microbiol Rev 19:597-613. 2006
    ..pylori resists immune clearance and also are relevant for understanding the pathogenesis of diseases caused by H. pylori (peptic ulcer disease, gastric adenocarcinoma, and gastric lymphoma)...
  97. ncbi Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylory isolates
    Dana J Philpott
    Unité de Pathogénie Microbienne Moléculaire INSERM U389, 28 rue du Dr Roux, Paris 75724, France
    Cell Microbiol 4:285-96. 2002
    ..This work provides evidence for in vivo selection of H. pylori bacteria with a reduced capacity to induce inflammatory responses and suggests that such bacteria are better adapted to colonize mice...
  98. ncbi The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk
    Ayca Sayi
    Institute of Molecular Cancer Research and
    J Immunol 182:7085-101. 2009
    ..In summary, our data suggest a dual role for IFN-gamma in Helicobacter pathogenesis that could be the basis for the differential susceptibility to H. pylori-induced gastric pathology in the human population...
  99. pmc Long term follow up of patients treated for Helicobacter pylori infection
    R Mera
    Department of Pathology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Gut 54:1536-40. 2005
    ..Understanding long term effects resulting from the cure of this infection is needed to design cancer prevention strategies...
  100. pmc CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions
    L A Sicinschi
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Microbiol Infect 16:369-78. 2010
    ..This novel finding may partially explain the difference in GC incidence in these populations...
  101. ncbi Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle?
    Henry J Windle
    School of Medicine, Trinity College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland
    Pediatrics 119:e754-9. 2007
    ..The consequent synergistic impact of diarrheal disease and micronutrient deficiency on growth and cognitive function in children has significant public health implications for socioeconomic development in these countries...

Research Grants54

  1. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
  2. PATHOGENESIS OF HELICOBACTER HEPATICUS
    CATHERINE BECKWITH; Fiscal Year: 2007
    ..assays, identification of virulence factors, and characterization of the pathogenesis of rodent Helicobacter infections. With the SERCA, Dr...
  3. Helicobacter hepaticus induced typhlitis
    MATTHEW MYLES; Fiscal Year: 2007
    ..Their combined expertise in the fields of rodent Helicobacter infections, host-pathogen interactions, animal model development, DNA array technology and analysis, cellular ..
  4. CHOLERA TOXIN--A MUCOSAL ADJUVANT, MECHANISMS & IMMUNITY
    John Nedrud; Fiscal Year: 1999
    ..Sendai virus infects the respiratory tract and is a murine parainfluenza virus. Helicobacter infections of gastric tissue have been implicated as causes of gastroduodenal ulcers and gastric cancer.
  5. INTERACTIONS OF HELICOBACTER WITH THE GASTRIC MUCOSA
    Donald Guiney; Fiscal Year: 2001
    ..the role of NO, prostaglandin E2, and cytokines in mediating both mucosal protection and damage during Helicobacter infections. We have preliminary data indicating that H...
  6. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  7. HELICOBACTER INFECTION AND GROWTH OF CHILDREN
    Pelayo Correa; Fiscal Year: 2001
    ..pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies. ..
  8. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  9. Immunoepidemiology of Concomittant Infection
    Sharon Perry; Fiscal Year: 2008
    ..S. foreign born and the developing world. ..
  10. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  11. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  12. Mechanism that regulate Helicobacter pylori-induced beta-caterin activation
    Richard Peek; Fiscal Year: 2009
    ..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
  13. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  14. H.pylori Effects on DNA Repair in Gastric Epithelium
    Antonia Sepulveda; Fiscal Year: 2008
    ..Knowledge gained from this study is likely to support the indication for Hp eradication in H. pylori-infected patients to prevent GC. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  15. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..Hence this approach will provide additional insights into mechanisms of regulation of gastric secretion and enable illuminated interpretation of the pathophysiology of peptic ulcer disease. ..
  16. Immunological Basis for H. Pylori-Related Malignancies
    Marygorret Obonyo; Fiscal Year: 2006
    ..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
  17. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  18. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    ..The results of the proposed research will further improve the agents used for the treatment of acid-related diseases and also our knowledge of the ATPase and cellular events involved in regulation of its activity. ..
  19. H. PYLORI-SPECIFIC REGULATORY T CELLS THAT LIMIT HOST RESPONSE
    Thomas Blanchard; Fiscal Year: 2008
    ..These studies will increase our understanding of gastrointestinal immunoregulation and the design of better immunotherapies. ..
  20. FUNCTION AND REGULATION OF GASTRIN
    Timothy Wang; Fiscal Year: 2008
    ..Overall, these studies will attempt to define the role of progastrin-derived peptides in stem cell regulation and in bridging genetic pathways in colorectal cancer. ..
  21. Development of a vaccine against Helicobacter pylori to prevent gastric cancer
    RODOLFO BEGUE; Fiscal Year: 2008
    ..pylori vaccine. And, prevention of H. pylori infection should eventually lead to elimination of its associated complications, including gastric cancer. [unreadable] [unreadable] [unreadable]..
  22. H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESIS
    Fritz Francois; Fiscal Year: 2008
    ..From these studies, both the microbial contribution and the host genotype contribution to adenocarcinoma risk should be able to be assessed, as well as to begin to define relevant cellular pathways. ..
  23. Enteric flora modulates the development of colitis
    Albert Jergens; Fiscal Year: 2008
    ..g., graduate students and postdoctoral fellow). There are ample opportunities to attend seminars, journal clubs and work-in-progress research meetings during which the applicant can become engaged in scientific discussions. ..
  24. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2008
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
  25. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
    ..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..
  26. Under the Skin: Understanding the Role of Stress and Immune Function in Health Di
    JENNIFER DOWD; Fiscal Year: 2009
    ..We will test whether these immune and infection markers are related to psychosocial and economic stressors and whether they mediate the relationship between SES and health outcomes including mortality. ..
  27. Inhibition of Fas-apoptosis in Gastric Cancer
    JeanMarie Houghton; Fiscal Year: 2010
    ..These studies will provide critical insight into novel preventive, and anti-cancer strategies aimed at restoring Fas sensitivity within tumor cells and provide a new direction for cancer treatment. ..
  28. Epidemiology and Incidence of Barrett's Esophagus
    DOUGLAS ALLEN CORLEY; Fiscal Year: 2010
    ..The proposed study explores how hormones associated with body fat may change the way the body heals after an injury, and increase the risk of cells developing precancerous changes. ..
  29. Stem Cells and Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ....
  30. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..
  31. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  32. Inhibitors to Clostridium perfrigens epsilon toxin
    MARK MCCLAIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. iNOS, COX-2, and Arginase in Murine Barrett's Esophagus
    Keith Wilson; Fiscal Year: 2003
    ..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs. iNOS -/-mice, and C. WT vs. argll -/- mice. ..
  34. THERAPY FOR GASTROINTESTINAL DISORDERS
    Elizabeth Dial; Fiscal Year: 2002
    ..Development of this therapeutic potential for rhLF will fulfill a crucial need for a way to safely administer NSAIDs. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  35. Role of Fas/NF kB in H.pylori induced gastric carcinoma
    JeanMarie Houghton; Fiscal Year: 2003
    ..Defining the regulation of these pathways will help define the complex relationship helicobacter shares with its host. ..
  36. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2004
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  37. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2001
    ..pylori infections. ..
  38. Immune response to Helicobacter pylori VacA as a marker
    Guillermo Perez Perez; Fiscal Year: 2004
    ..If our hypothesis is correct, we hope to establish a simple and economical serological test to assess the risk of gastric cancer development. ..
  39. Recombinant murine IL-10 produced in situ by H. pylori
    KATHRYN EATON; Fiscal Year: 2005
    ..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
  40. Genetics of Turner Syndrome Neurocognitive Phenotype
    Andrew Zinn; Fiscal Year: 2006
    ..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
  41. Probiotic Modulation/Dendritic Cells in Experimental IBD
    Maureen Drakes; Fiscal Year: 2006
    ..Findings from these studies will provide a better understanding of the therapeutic mechanisms of probiotics in inflammatory bowel disease. ..
  42. CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIA
    Chaim Hershko; Fiscal Year: 2001
    ..abstract_text> ..
  43. Mechanisms of H pylori-Induced Hypochlorhydria
    Adam Smolka; Fiscal Year: 2008
    ..pylori strain identity, and anatomic site of infection. These studies will establish the mechanistic basis of H. pylori-induced gastric hypochlorhydria, and add to the understanding of H. pylori pathophysiology. ..
  44. 14th International Symposium on Regulatory Peptides
    Timothy Wang; Fiscal Year: 2002
    ..abstract_text> ..
  45. NEUROENDOCRINE MEDIATION OF E. COLI 0157:H7 INFECTION
    Mark Lyte; Fiscal Year: 2003
    ..The demonstration of direct neuroendocrine-bacterial interaction as a mechanism in the pathogenesis of E. coli O157:H7 infection may yield new treatments for both the prevention and treatment of hemorrhagic colitis. ..
  46. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  47. Development of furanones for treatment of anthrax
    Martin Blaser; Fiscal Year: 2005
    ..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
  48. H. Pylory factors associated with peptic ulcer disease
    TIMOTHY COVER; Fiscal Year: 2006
    ..pylori factors that help to determine clinical outcome, and ultimately, may lead to advances in the treatment or prevention of H. pylori-associated human diseases. [unreadable] [unreadable]..
  49. Surrogate Biomarkers of Micrometastatic Gastric Cancer
    Adam Smolka; Fiscal Year: 2004
    ..The successful development and validation of a lymph node RT-PCR-based assay for micrometastatic stomach cancer is likely to have a significant clinical impact. ..
  50. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
  51. Gut to Brain Pathways for Infection-Induced Anxiety
    Mark Lyte; Fiscal Year: 2005
    ..abstract_text> ..
  52. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2002
    ..abstract_text> ..
  53. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2002
    ....