klebsiella infections

Summary

Summary: Infections with bacteria of the genus KLEBSIELLA.

Top Publications

  1. pmc Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors
    R Podschun
    Department of Medical Microbiology and Virology, University of Kiel, Kiel, Germany
    Clin Microbiol Rev 11:589-603. 1998
  2. ncbi The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    Patrice Nordmann
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, K Bicêtre, France
    Lancet Infect Dis 9:228-36. 2009
  3. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
  4. ncbi ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China
    Yan Qi
    Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    J Antimicrob Chemother 66:307-12. 2011
  5. ncbi Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies
    Gopi Patel
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Infect Control Hosp Epidemiol 29:1099-106. 2008
  6. ncbi An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009-10)
    Panagiota Giakkoupi
    Department of Microbiology, National School of Public Health, Athens, Greece
    J Antimicrob Chemother 66:1510-3. 2011
  7. pmc Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis
    Keh Ming Wu
    Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan
    J Bacteriol 191:4492-501. 2009
  8. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
  9. pmc Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns
    Wen Chien Ko
    National Cheng Kung University Medical College, Taiwan
    Emerg Infect Dis 8:160-6. 2002
  10. pmc Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization
    Sylvain Brisse
    Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France
    PLoS ONE 4:e4982. 2009

Detail Information

Publications269 found, 100 shown here

  1. pmc Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors
    R Podschun
    Department of Medical Microbiology and Virology, University of Kiel, Kiel, Germany
    Clin Microbiol Rev 11:589-603. 1998
    ..Klebsiella pathogenicity factors such as capsules or lipopolysaccharides are presently considered to be promising candidates for vaccination efforts that may serve as immunological infection control measures...
  2. ncbi The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    Patrice Nordmann
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, K Bicêtre, France
    Lancet Infect Dis 9:228-36. 2009
    ..Detection of KPC-producing bacteria may be difficult based on routine antibiotic susceptibility testing. It is therefore crucial to implement efficient infection control measures to limit the spread of these pathogens...
  3. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
    ..pneumoniae infection. These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia...
  4. ncbi ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China
    Yan Qi
    Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    J Antimicrob Chemother 66:307-12. 2011
    ..Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae has spread rapidly in China. In this study, we aimed to investigate the molecular epidemiology of KPC-producing K. pneumoniae isolates in China...
  5. ncbi Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies
    Gopi Patel
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Infect Control Hosp Epidemiol 29:1099-106. 2008
    ..Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen...
  6. ncbi An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009-10)
    Panagiota Giakkoupi
    Department of Microbiology, National School of Public Health, Athens, Greece
    J Antimicrob Chemother 66:1510-3. 2011
    ..To follow the epidemic of KPC-2-producing Klebsiella pneumoniae in Greece...
  7. pmc Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis
    Keh Ming Wu
    Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan
    J Bacteriol 191:4492-501. 2009
    ..pneumoniae pathogenic strains. Our findings support the hypothesis that these factors are responsible for the changes that have occurred in the disease profile over time...
  8. pmc A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
    C P Fung
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Gut 50:420-4. 2002
    ..However, the relationship between the clinical presentation and bacterial factors remains unclear. The aim of this study was to investigate the clinical features of patients and the serotype and ribotype of K pneumoniae liver abscess...
  9. pmc Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns
    Wen Chien Ko
    National Cheng Kung University Medical College, Taiwan
    Emerg Infect Dis 8:160-6. 2002
    ..A distinctive form of K. pneumoniae infection, often causing liver abscess, was identified, almost exclusively in Taiwan...
  10. pmc Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization
    Sylvain Brisse
    Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France
    PLoS ONE 4:e4982. 2009
    ..pneumoniae...
  11. pmc Klebsiella pneumoniae in gastrointestinal tract and pyogenic liver abscess
    Chang Phone Fung
    Taipei Veterans General Hospital, Taipei, Taiwan
    Emerg Infect Dis 18:1322-5. 2012
    ..This finding indicated that gastrointestinal carriage is a predisposing factor for liver abscess...
  12. pmc Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections
    Victor L Yu
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Emerg Infect Dis 13:986-93. 2007
    ..001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism...
  13. ncbi Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes
    E Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Clin Infect Dis 32:1162-71. 2001
    ..coli and K. pneumoniae should emphasize judicious use of all antibiotics as well as barrier precautions to reduce spread...
  14. pmc Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence
    Yu Kuo Tsai
    Division of Infectious Diseases, National Health Research Institutes, Miaoli, Taiwan
    Antimicrob Agents Chemother 55:1485-93. 2011
    ..01) lower virulence, whereas the ΔompK35/36 mutant presented the highest 50% lethal dose of these strains. In conclusion, porin deficiency in K. pneumoniae could increase antimicrobial resistance but decrease virulence at the same time...
  15. ncbi Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model
    Matthew S Lawlor
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Microbiol 58:1054-73. 2005
    ..Subsequent experiments support the premise that the central mechanism of K. pneumoniae pathogenesis is the production of a polysaccharide-rich cell surface that provides protection from the inflammatory response...
  16. ncbi Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium
    Simona Bratu
    Division of Infectious Diseases, State University of New York Downstate, Brooklyn, NY 11203, USA
    Arch Intern Med 165:1430-5. 2005
    ..In this study, the prevalence and molecular epidemiologic characteristics of carbapenem-resistant K pneumoniae are analyzed, and the experience involving 2 hospital outbreaks is described...
  17. ncbi An outbreak of infection due to beta-Lactamase Klebsiella pneumoniae Carbapenemase 2-producing K. pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes
    Maria Souli
    4th Dept of Internal Medicine, University General Hospital Attikon, 1 Rimini Str 124 62, Chaidari, Greece
    Clin Infect Dis 50:364-73. 2010
    ..We describe the emergence and spread of Klebsiella pneumoniae carbapenemase 2 (KPC-2)-producing K. pneumoniae at a Greek University hospital...
  18. ncbi High prevalence of phagocytic-resistant capsular serotypes of Klebsiella pneumoniae in liver abscess
    Jung Chung Lin
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, Taipei, Taiwan
    Microbes Infect 6:1191-8. 2004
    ..These findings indicate that resistance of CPS K1 or K2 K. pneumoniae to phagocytosis and intracellular killing presumably contributes to their high prevalence in liver abscess and uniquely in endophthalmitis...
  19. pmc Epidemiology and outcome of Klebsiella species bloodstream infection: a population-based study
    Majdi N Al-Hasan
    Department of Medicine, University of Kentucky Chandler Medical Center, 800 Rose St, Room MN 672, Lexington, KY 40536, USA
    Mayo Clin Proc 85:139-44. 2010
    ..To determine incidence rate, seasonal variation, and short- and long-term outcomes of Klebsiella species bloodstream infection (BSI) in a population-based setting...
  20. pmc Emerging severe and fatal infections due to Klebsiella pneumoniae in two university hospitals in France
    Dominique Decré
    Laboratoire de Bacteriologie, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
    J Clin Microbiol 49:3012-4. 2011
    ..Two clones (sequence type 86 [ST86] and ST380) of serotype K2 caused five rapidly fatal bacteremia cases, three of which were associated with pneumonia, whereas seven liver abscess cases were caused by K1 strains of ST23...
  21. pmc Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome
    Mario Tumbarello
    Departments of Infectious Diseases, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Antimicrob Agents Chemother 50:498-504. 2006
    ..62; 95% CI, 1.28 to 5.35). In summary, this investigation identifies epidemiological characteristics that distinguish ESBL-producing K. pneumoniae infections from non-ESBL-producing K. pneumoniae ESBL bloodstream infections...
  22. ncbi Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece)
    H C Maltezou
    Department for Interventions in Health Care Facilities, Hellenic Centre for Disease Control and Prevention, Athens, Greece
    J Infect 58:213-9. 2009
    ..Our efforts should focus on rational use of available antibiotics, enhancement of infection control measures, and implementation of active antibiotic resistance surveillance...
  23. pmc Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: a matched case-control study
    Olympia Zarkotou
    Department of Microbiology, Tzaneio General Hospital, Piraeus, Greece
    J Clin Microbiol 48:2271-4. 2010
    ..None of these parameters independently predicted colistin resistance, which probably occurred in a susceptible KPC-KP strain that was subsequently disseminated horizontally...
  24. ncbi Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection
    Elizabeth B Hirsch
    University of Houston College of Pharmacy, and St Luke s Episcopal Hospital, Houston, TX, USA
    J Antimicrob Chemother 65:1119-25. 2010
    ..Studies examining combination therapy and well-controlled clinical trials are needed to ascertain the optimal treatment of infections caused by KPC bacteria...
  25. pmc A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei 100
    J Exp Med 199:697-705. 2004
    ..We conclude that magA fits molecular Koch's postulates as a virulence gene. Thus, this locus can be used as a marker for the rapid diagnosis and for tracing the source of this emerging infectious disease...
  26. ncbi Cloverleaf test (modified Hodge test) for detecting carbapenemase production in Klebsiella pneumoniae: be aware of false positive results
    Cecilia G Carvalhaes
    Laboratório ALERTA, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    J Antimicrob Chemother 65:249-51. 2010
    ..The aim of this study was to evaluate the presence of carbapenemases in a Klebsiella pneumoniae collection and the performance of the modified Hodge test (MHT) to correctly identify this phenotype...
  27. pmc Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene
    Thierry Naas
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicêtre 94275, and Faculté de Médecine Paris Sud, Paris, France
    Antimicrob Agents Chemother 52:1257-63. 2008
    ..Tn4401 is likely at the origin of carbapenem-hydrolyzing beta-lactamase KPC mobilization to plasmids and its further insertion into various-sized plasmids identified in nonclonally related K. pneumoniae and P. aeruginosa isolates...
  28. pmc Capsular polysaccharide synthesis regions in Klebsiella pneumoniae serotype K57 and a new capsular serotype
    Yi Jiun Pan
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Clin Microbiol 46:2231-40. 2008
    ..We conclude that sequences from these two cps regions are very useful in detecting K57 and the new cps genotype...
  29. ncbi Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection
    Ren Wen Tsay
    Division of Infectious Diseases and Tropical Medicine, Tri Service General Hospital, No 325, Section 2, Cheng Kung Road, Neihu, 114 Taipei, Taiwan
    Arch Intern Med 162:1021-7. 2002
    ..Although several epidemiological surveys of Klebsiella clinical isolates have been performed, few studies have correlated the clinical isolate with disease...
  30. ncbi Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections
    D Ben-David
    Infectious Diseases Unit, Sheba Medical Center, Tel Hashomer, Israel
    Clin Microbiol Infect 18:54-60. 2012
    ..pneumoniae. Independent risk factors for infection-related mortality were Pitt bacteraemia score, Charlson score and carbapenem resistance...
  31. ncbi Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment
    O Zarkotou
    Department of Microbiology, Tzaneio General Hospital, Piraeus, Greece
    Clin Microbiol Infect 17:1798-803. 2011
    ..Independent predictors of mortality were age, APACHE II score at infection onset and inappropriate antimicrobial treatment. Among them, appropriate treatment is the only modifiable independent predictor of infection outcome...
  32. pmc oxyR, a LysR-type regulator involved in Klebsiella pneumoniae mucosal and abiotic colonization
    Claire Hennequin
    Université de Clermont 1, UFR Pharmacie, Laboratoire de Bacteriologie, 28 Place Henri Dunant, Clermont Ferrand F 63001, France
    Infect Immun 77:5449-57. 2009
    ..These results show the pleiotropic role of oxyR in K. pneumoniae gastrointestinal colonization...
  33. ncbi Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea
    D R Chung
    Division of Infectious Diseases, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi do 431 070, South Korea
    J Infect 54:578-83. 2007
    ..To investigate a current epidemiology of K. pneumoniae liver abscess in Korea and to determine K serotype distribution in K. pneumoniae strains causing liver abscess, we performed a nationwide prospective study...
  34. pmc Isolation of genes involved in biofilm formation of a Klebsiella pneumoniae strain causing pyogenic liver abscess
    Meng Chuan Wu
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    PLoS ONE 6:e23500. 2011
    ..pneumoniae clinical isolates and to screen for biofilm-altered mutants from a transposon mutant library of a K. pneumoniae PLA-associated strain...
  35. pmc Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan
    L Kristopher Siu
    Division of Infectious Diseases, National Health Research Institutes, Taichung, Taiwan
    J Clin Microbiol 49:3761-5. 2011
    ..Serotype K1 K. pneumoniae isolates with capsule expression leading to phagocytic resistance and with the aerobactin gene were associated with hypervirulence...
  36. ncbi Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella
    J J Rahal
    Department of Medicine, New York Hospital Medical Center of Queens and Cornell University Medical College, Flushing 11355, USA
    JAMA 280:1233-7. 1998
    ..Resistance to most or all cephalosporin antibiotics in Klebsiella species has developed in many European and North American hospitals during the past 2 decades...
  37. pmc Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection
    Shanshan Cai
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    J Immunol 183:6629-38. 2009
    ..pneumoniae infection in the lungs and demonstrate the therapeutic potential of MyD88 in reducing excessive neutrophil influx in human disease during Gram-negative bacterial pneumonia...
  38. pmc Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA
    Andrea Endimiani
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Research Service, Cleveland, OH 44106, USA
    J Antimicrob Chemother 63:427-37. 2009
    ..Outbreaks in the Eastern USA have created serious treatment and infection control problems. A comparative multi-institutional analysis of these strains has not yet been performed...
  39. pmc Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan
    Kuo Ming Yeh
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    J Clin Microbiol 45:466-71. 2007
    ..The characteristics of K. pneumoniae liver abscess in Singapore and Taiwan are similar. Capsular serotype K1 or K2 plays a more important role than magA and rmpA in determining virulence in K. pneumoniae liver abscess...
  40. ncbi Klebsiella pneumoniae carbapenemases in Enterobacteriaceae: history, evolution, and microbiology concerns
    Robert P Rapp
    College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    Pharmacotherapy 32:399-407. 2012
    ....
  41. ncbi Complete sequencing of an IncH plasmid carrying the blaNDM-1, blaCTX-M-15 and qnrB1 genes
    Laura Villa
    Department of Infectious, Parasitic and Immuno Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Antimicrob Chemother 67:1645-50. 2012
    ....
  42. pmc Pyogenic liver abscess as endemic disease, Taiwan
    Feng Chiao Tsai
    National Taiwan University Hospital, Taipei, Taiwan
    Emerg Infect Dis 14:1592-600. 2008
    ..Diabetes did not significantly change death rates for the 506 patients from the hospital...
  43. pmc Bacteremic community-acquired pneumonia due to Klebsiella pneumoniae: clinical and microbiological characteristics in Taiwan, 2001-2008
    Yi Tsung Lin
    Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    BMC Infect Dis 10:307. 2010
    ..This retrospective study evaluated the clinical and microbiological characteristics of bacteremic community-acquired pneumonia due to K. pneumoniae in Taiwanese adults...
  44. pmc Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain
    Yi Chun Lin
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    BMC Microbiol 11:50. 2011
    ..Nevertheless, the emergence of tissue-abscesses-associated HV-negative isolates motivated us to re-evaluate the role of HV-phenotype...
  45. ncbi Characteristics of healthcare-associated and community-acquired Klebsiella pneumoniae bacteremia in Taiwan
    Hau Shin Wu
    Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, 112, Taipei, Taiwan
    J Infect 64:162-8. 2012
    ..We investigated the clinical features and outcomes of community-acquired (CA) and healthcare-associated (HCA) infections among community-onset K. pneumoniae bacteremia...
  46. ncbi CTX-M-15-producing Escherichia coli clinical isolates in Cairo (Egypt), including isolates of clonal complex ST10 and clones ST131, ST73, and ST405 in both community and hospital settings
    Nevine Fam
    Microbiology Department, Theodor Bilharz Research Institute, Cairo, Egypt
    Microb Drug Resist 17:67-73. 2011
    ..Multilocus sequence typing showed that 75% of E. coli group B2 belonged to clone ST131. This indicates that a new country in Africa is adversely affected by clones of E. coli-producing CTX-M-15...
  47. ncbi Clinical and phenotypic differences between classic and hypervirulent Klebsiella pneumonia: an emerging and under-recognized pathogenic variant
    D K Pomakova
    Veterans Administration Western New York Healthcare System, Buffalo, NY, USA
    Eur J Clin Microbiol Infect Dis 31:981-9. 2012
    ..This will improve our understanding of the epidemiology and clinical spectrum of infection, which may be more extensive than appreciated...
  48. ncbi Carriage rate of carbapenem-resistant Klebsiella pneumoniae in hospitalised patients during a national outbreak
    Y Wiener-Well
    Infectious Disease Unit, Shaare Zedek Medical Center, Jerusalem, affiliated with the Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Hosp Infect 74:344-9. 2010
    ..4%. The clonal origin of these isolates suggests that strict adherence to isolation procedure may contain this outbreak...
  49. ncbi Potential role of active surveillance in the control of a hospital-wide outbreak of carbapenem-resistant Klebsiella pneumoniae infection
    Debby Ben-David
    Infectious Diseases Unit, Sheba Medical Center, Tel Hashomer, Israel
    Infect Control Hosp Epidemiol 31:620-6. 2010
    ..The recent emergence of carbapenem resistance among Enterobacteriaceae is a major threat for hospitalized patients, and effective strategies are needed...
  50. pmc High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe
    Frank M Kaczmarek
    Pfizer Global Research and Development, Groton, CT 06340, USA
    Antimicrob Agents Chemother 50:3396-406. 2006
    ..Our results with this pair of Klebsiella clinical isolates highlight the complex and evolving nature of multiple drug resistance in this species...
  51. ncbi Extended spectrum beta-lactamases (ESBL) in Escherichia coli and Klebsiella pneumoniae: trends in the hospital and community settings
    Husam S Khanfar
    Department of Microbiology and Epidemiology, Dhahran Health Centre, Saudi Aramco Company, Eastern Province, Saudi Arabia
    J Infect Dev Ctries 3:295-9. 2009
    ..To assess the prevalence of extended spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella strains in nosocomial and community-acquired infections...
  52. ncbi The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited
    Chun Ru Hsu
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    Microbiology 157:3446-57. 2011
    ..We found an association of p-rmpA with three widely spaced loci in a large plasmid (30/32). Therefore, rmpA could be co-inherited together with virulence genes carried by this plasmid...
  53. pmc Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing
    Evan S Snitkin
    National Human Genome Research Institute, Bethesda, MD 20892, USA
    Sci Transl Med 4:148ra116. 2012
    ..Our analysis demonstrates that integration of genomic and epidemiological data can yield actionable insights and facilitate the control of nosocomial transmission...
  54. ncbi Endogenous Klebsiella endophthalmitis associated with pyogenic liver abscess
    Chang Sue Yang
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    Ophthalmology 114:876-80. 2007
    ..pneumoniae-induced pyogenic liver abscess, and to investigate contributing factors in successfully treated cases...
  55. pmc Risk factors and clinical impact of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae
    Leanne B Gasink
    Division of Infectious Diseases, Department of Medicine, and the Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Infect Control Hosp Epidemiol 30:1180-5. 2009
    ..pneumoniae is an emerging pathogen with serious clinical and infection control implications. To our knowledge, no study has specifically examined risk factors for KPC-producing K. pneumoniae or its impact on mortality...
  56. pmc Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae?
    Jung Chung Lin
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, and Institute of Clinical Medicine, School of Medicine, Naitonal Yang Ming University, Taipei, Taiwan
    PLoS ONE 5:e15005. 2010
    ..Thus, neutrophils play a role as a vehicle for helping K. pneumoniae and contributing to the establishment of liver abscess and distant metastatic complications...
  57. pmc Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:2108-13. 2012
    ..7% (8/12). The use of combination therapy for definitive therapy appears to be associated with improved survival in bacteremia due to KPC-producing K. pneumoniae...
  58. ncbi Lipopolysaccharide O-antigen promotes persistent murine bacteremia
    Joanelle Z Lugo
    Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Shock 27:186-91. 2007
    ....
  59. ncbi Ongoing epidemic of blaVIM-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey
    M Psichogiou
    First Department of Propaedeutic Medicine, Medical School, University of Athens, Athens, Greece
    J Antimicrob Chemother 61:59-63. 2008
    ..To determine the current frequency and study the characteristics of VIM-1-producing Klebsiella pneumoniae isolates from bloodstream infections in Greek hospitals...
  60. pmc Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2
    Michael A Bachman
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 79:3309-16. 2011
    ..However, Lcn2 retained partial protection against disseminated disease. In summary, Ybt is a virulence factor that is prevalent among KPC-producing K. pneumoniae isolates and promotes respiratory tract infections through evasion of Lcn2...
  61. pmc Treatment and outcomes in carbapenem-resistant Klebsiella pneumoniae bloodstream infections
    Elizabeth A Neuner
    Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA
    Diagn Microbiol Infect Dis 69:357-62. 2011
    ..In summary, CR-Kp bloodstream infections occur in patients who are chronically and acutely ill. They are associated with high 14-day mortality and poor outcomes regardless of tigecycline or other treatment regimens selected...
  62. pmc Dissemination of clinical isolates of Klebsiella oxytoca harboring CMY-31, VIM-1, and a New OXY-2-type variant in the community
    Athanassios Tsakris
    Department of Microbiology, Medical School, University of Athens, Athens, Greece
    Antimicrob Agents Chemother 55:3164-8. 2011
    ..This is the first study to present the dissemination in the community of multidrug-resistant K. oxytoca isolates causing extrahospital infections...
  63. ncbi Outbreak of Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae with high qnr prevalence in a Chinese hospital
    Rong Zhang
    2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou 310009, PR China
    J Med Microbiol 60:977-82. 2011
    ..The bla(KPC-2) gene is associated with several antibiotic-resistance genes, such as bla(TEM), bla(SHV), bla(CTX-M) and qnr...
  64. pmc Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine
    Michael J Satlin
    Department of Medicine, Weill Cornell Medical College, New York, New York 10021, USA
    Antimicrob Agents Chemother 55:5893-9. 2011
    ..Treatment with an aminoglycoside, when active in vitro, was associated with a significantly higher rate of microbiologic clearance of CRKP bacteriuria than treatment with either polymyxin B or tigecycline...
  65. ncbi Foodborne nosocomial outbreak of SHV1 and CTX-M-15-producing Klebsiella pneumoniae: epidemiology and control
    Esther Calbo
    Infectious Diseases Unit, Service of Internal Medicine, Hospital Universitari Mutua de Terrassa, Barcelona, Spain
    Clin Infect Dis 52:743-9. 2011
    ..We describe a foodborne nosocomial outbreak due to extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae...
  66. pmc Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States
    Andrea Endimiani
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 52:2680-2. 2008
    ..One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids...
  67. pmc Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258
    Tatiana Bogdanovich
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 53:373-6. 2011
    ..These cases likely represented both emergence of resistance and transmission of resistant organism. The colistin-resistant isolates were able to persist in the absence of selective pressure in vitro...
  68. pmc Evolution of IncA/C blaCMY-₂-carrying plasmids by acquisition of the blaNDM-₁ carbapenemase gene
    Alessandra Carattoli
    Department of Infectious, Parasitic, and Immuno Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Antimicrob Agents Chemother 56:783-6. 2012
    ..Considering that IncA/C plasmids possess a broad host range, this scaffold might support a large-scale diffusion of the bla(NDM-1) gene among Gram-negative rods...
  69. pmc First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America
    Maria Virginia Villegas
    CIDEIM International Center for Medical Research and Training, Cali, Colombia
    Antimicrob Agents Chemother 50:2880-2. 2006
    ..These KPC enzymes are the first from South America and the second isolation outside of the United States. The expanding geographic spread of KPC carbapenemases underscores the importance of clinical recognition of these enzymes...
  70. ncbi Prognostic factors and outcomes in endogenous Klebsiella pneumoniae endophthalmitis
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Am J Ophthalmol 151:338-44.e2. 2011
    ..To determine risk factors for poor visual acuity outcomes in patients with endogenous Klebsiella pneumoniae endophthalmitis...
  71. ncbi Carbapenem-resistant Klebsiella pneumoniae bacteremia: factors correlated with clinical and microbiologic outcomes
    May Nguyen
    Department of Pharmacy, NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    Diagn Microbiol Infect Dis 67:180-4. 2010
    ..Our data suggest that severity of illness, rapid microbiologic eradication, and source control are crucial factors in the outcomes of patients with CRKP bacteremia...
  72. pmc Molecular characterization of newly emerged blaKPC-2-producing Klebsiella pneumoniae in Singapore
    Michelle N D Balm
    Department of Laboratory Medicine, National University Hospital, Singapore
    J Clin Microbiol 50:475-6. 2012
    ..bla(KPC-2) was located on nonconjugative plasmids and flanked by mobile genetic structures composed of a partial Tn4401 transposon and a Tn3-based transposon which previously have been described only in Chinese isolates...
  73. ncbi Ankylosing spondylitis is linked to Klebsiella--the evidence
    Taha Rashid
    School of Biomedical and Health Sciences, King s College London, 150 Stamford Street, London, SE1 9NN, UK
    Clin Rheumatol 26:858-64. 2007
    ..Prospective longitudinal studies with the use of anti-microbial measures in patients with AS are required to establish the therapeutic benefit of this microbe-disease association...
  74. ncbi Molecular epidemiology and risk factors of bloodstream infections caused by extended-spectrum beta-lactamase-producing Klebsiella pneumoniae A case-control study
    Juan L Mosqueda-Gómez
    School of Medicine, University of Guanajuato, Leon, Guanajuato, Mexico
    Int J Infect Dis 12:653-9. 2008
    ....
  75. ncbi Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Yungkang City, Tainan, Taiwan
    Clin Infect Dis 42:1351-8. 2006
    ..However, the association of rmpA with K. pneumoniae clinical syndromes is unreported. We aimed to investigate the clinical correlation between rmpA and primary Klebsiella abscess, focusing on sites other than the liver...
  76. ncbi Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents
    Deverick J Anderson
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Infect Dis 197:752-6. 2008
    ..The objective of this study was to determine whether the incidence of K. pneumoniae bloodstream infection (BSI) was higher during warm months...
  77. ncbi International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections
    David L Paterson
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Ann Intern Med 140:26-32. 2004
    ..Commonly encountered nosocomially acquired gram-negative bacteria, especially Klebsiella pneumoniae, produce extended-spectrum beta-lactamases (ESBLs) as an antibiotic resistance mechanism...
  78. ncbi Genomic heterogeneity in Klebsiella pneumoniae strains is associated with primary pyogenic liver abscess and metastatic infection
    Li Chen Ma
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Infect Dis 192:117-28. 2005
    ..Primary pyogenic liver abscess (PLA) with septic complication by Klebsiella pneumoniae is an emerging infectious disease...
  79. ncbi Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type beta-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005--the new 'MRSAs'?
    Ivelina Damjanova
    Department of Phage Typing and Molecular Epidemiology, National Center for Epidemiology, Gyali ut 2 6, 1097 Budapest, Hungary
    J Antimicrob Chemother 62:978-85. 2008
    ..To investigate the molecular epidemiology of ciprofloxacin-resistant CTX-M-15-producing Klebsiella pneumoniae epidemic clones (ECs) isolated from six nosocomial outbreaks and sporadic cases during 2005 in Hungary...
  80. ncbi Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case control study
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 60:1124-30. 2007
    ..Thus, the emergence of infections due to carbapenem-resistant K. pneumoniae (CRKp) is a major public health concern...
  81. ncbi Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess
    Susan Shin Jung Lee
    Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Clin Infect Dis 47:642-50. 2008
    ..Primary liver abscess caused by Klebsiella pneumoniae is an infection that is emerging worldwide and that is associated with severe morbidity and considerable mortality...
  82. pmc Genetic requirements for Klebsiella pneumoniae-induced liver abscess in an oral infection model
    Ya Chun Tu
    Department of Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan, Republic of China
    Infect Immun 77:2657-71. 2009
    ..pneumoniae infections...
  83. ncbi Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics
    Edith R Lederman
    U S Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Gastroenterol 100:322-31. 2005
    ..We examined the microbiologic trends of pyogenic liver abscess at our institution to determine if a similar shift in etiologic agents was occurring...
  84. ncbi Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns
    Khetam Hussein
    Infectious Diseases Unit, Rambam Medical Center, Haifa, Israel
    Infect Control Hosp Epidemiol 30:666-71. 2009
    ..Carbapenem resistance among isolates of Klebsiella pneumoniae has been unusual...
  85. ncbi Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Clin Infect Dis 52:848-55. 2011
    ..A nationwide intervention was launched to contain the outbreak and to introduce a strategy to control future dissemination of antibiotic-resistant bacteria in hospitals...
  86. pmc Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France
    Gaelle Cuzon
    Service de Bacteriologie Virologie, INSERM U914, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:2420-3. 2011
    ..This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France...
  87. pmc Recurrent Klebsiella pneumoniae liver abscess: clinical and microbiological characteristics
    Ya Sung Yang
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R O C
    J Clin Microbiol 47:3336-9. 2009
    ..Most of the patients had diabetes and K1 serotype KLAs. All of the isolates were uniformly susceptible to cefazolin. Distinct molecular fingerprints were found for the strains isolated from both primary and recurrent KLAs...
  88. pmc Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 48:4793-9. 2004
    ..Although producers of these enzymes remain rare, the progress of this enzyme group merits monitoring...
  89. pmc Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality
    Mitchell J Schwaber
    Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 52:1028-33. 2008
    ..6; and P = 0.03; for the CRKP group versus the controls, OR, 5.0; 95% CI, 1.7 to 14.8; and P = 0.004). CRKP affects patients with poor functional status, an ICU stay, and antibiotic exposure and is an independent predictor of death...
  90. ncbi Exudate macrophages attenuate lung injury by the release of IL-1 receptor antagonist in gram-negative pneumonia
    Susanne Herold
    Department of Internal Medicine II, University of Giessen Lung Center, Giessen, Germany
    Am J Respir Crit Care Med 183:1380-90. 2011
    ..Exudate macrophages are key players in host defense toward invading pathogens. Their antiinflammatory and epithelial-protective potential in gram-negative pneumonia, however, remains elusive...
  91. pmc Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob
    Stephen P Hawser
    IHMA Europe Sàrl, 4 Route de la Corniche, 1066 Epalinges, Switzerland
    Antimicrob Agents Chemother 54:3043-6. 2010
    ..0% versus 6.5%, respectively, for E. coli (P < 0.001) and 20.9% versus 5.3%, respectively, for K. pneumoniae (P < 0.01). Carbapenems were consistently the most active drugs tested...
  92. pmc Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae
    Alexey Ruzin
    Department of Infectious Disease, Wyeth Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 52:3430-2. 2008
    ..At MICs of 4 and 8 microg/ml, the expression of ramA was statistically significantly different from MICs of 2 microg/ml or less, supporting the tigecycline susceptibility breakpoint of <or=2 microg/ml for K. pneumoniae...
  93. pmc ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline
    M Hentschke
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
    Antimicrob Agents Chemother 54:2720-3. 2010
    ..Thus, this study reveals a molecular mechanism for tigecycline resistance in Klebsiella pneumoniae...
  94. ncbi Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan
    Diagn Microbiol Infect Dis 62:1-6. 2008
    ..Without significant difference in the prevalence of expressing hypermucoviscosity phenotype and carriage of rmpA and aerobactin genes, these virulent non-K1/K2 isolates are as capable as K1/K2 isolates of causing primary liver abscesses...
  95. ncbi Genetic determinants of capsular serotype K1 of Klebsiella pneumoniae causing primary pyogenic liver abscess
    Yi Ping Chuang
    Department of Microbiology, National Taiwan University College of Medicine, and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    J Infect Dis 193:645-54. 2006
    ..Primary pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae is an emerging infectious disease. Capsular serotype K1 and the magA gene have been reported to be associated with this disease...
  96. pmc First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Israel
    Antimicrob Agents Chemother 53:818-20. 2009
    ..The threat of the global spread of hyperepidemic, extensively drug-resistant bacterial strains should be recognized and confronted...
  97. ncbi Genetically similar isolates of Klebsiella pneumoniae serotype K1 causing liver abscesses in three continents
    Jane F Turton
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Med Microbiol 56:593-7. 2007
    ..This study indicates that a genotype strongly associated with highly invasive disease in Taiwan, where large numbers of cases have been reported, is geographically very widespread...
  98. ncbi Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae
    Ching Cheng Yang
    Division of Infectious Disease, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, ROC
    J Microbiol Immunol Infect 37:176-84. 2004
    ..5% vs 6.4%). We also found that the presence of respiratory symptoms (including cough, dyspnea, or chest distress), size of abscess > or =5 cm in diameter and non-K. pneumoniae pathogens were significant prognostic factors for mortality...
  99. pmc Prevalence and significance of a negative extended-spectrum beta-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: results from the SENTRY Asia-Pacific Surveil
    Jan M Bell
    Women s and Children s Hospital, Adelaide, South Australia 5006, Australia
    J Clin Microbiol 45:1478-82. 2007
    ..coli and K. pneumoniae from the Asia-Pacific region harbor important beta-lactamases, and a positive screening test alone should be sufficient grounds to report resistance to extended-spectrum cephalosporins in this region...
  100. pmc Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory
    D L Paterson
    Infectious Disease Division, University of Pittsburgh VA Medical Center, University Dr. C, Pittsburgh, PA 15240, USA
    J Clin Microbiol 39:2206-12. 2001
    ..coli even when cephalosporin MICs are in the susceptible range (<or = 8 microg/ml) and to report ESBL-producing organisms as resistant to aztreonam and all cephalosporins (with the exception of cephamycins)...
  101. ncbi Dissemination of bla(IMP-1)-carrying integron In86 among Klebsiella pneumoniae isolates harboring a new trimethoprim resistance gene dfr23
    Andréia P Penteado
    Laboratório ALERTA, Division of Infectious Diseases, Universidade Federal de Sao Paulo, São Paulo 04039 032, Brazil
    Diagn Microbiol Infect Dis 63:87-91. 2009
    ....

Research Grants31

  1. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..susceptibility data to choose and modify treatment regimens for MDR-Acinetobacter, Pseudomonas, and Klebsiella infections. We propose to investigate factors that lead providers to request certain susceptibility or synergy tests ..
  2. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  3. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
  4. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  5. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  6. New Nosocomial Interventions to Decrease Antimicrobial Resistance Transmission
    Anthony Harris; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
  8. PSEUDOMONAS AERUGINOSA FLAGELLAR BIOGENESIS PATHWAY
    Reuben Ramphal; Fiscal Year: 2007
    ..abstract_text> ..
  9. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. Iron Homeostasis in Salmonella-Host Interactions
    Ferric C Fang; Fiscal Year: 2010
    ..This work will have fundamental implications for understanding the strategies by which pathogenic microbes evade innate immunity by minimizing iron- dependent cell damage and maintaining iron homeostasis. ..
  11. DNA DAMAGE AND REPAIR IN SALMONELLA PATHOGENESIS
    Ferric Fang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  12. ALCOHOLISM:ALTERED ALVEOLAR MATRIX AND ACUTE LUNG INJURY
    Lou Ann Brown; Fiscal Year: 2003
    ....
  13. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  15. CHRONIC ETHANOL: MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS
    LOU ANN SCISM BROWN; Fiscal Year: 2010
    ..3) Determine if strategies to relieve ER stress will rescue the alcoholic AT2 cell from its pro-apoptotic phenotype. 4) Determine if relief of ER stress will rescue AT2 cell apoptosis in the alcoholic lung during endotoxemia. ..
  16. The influence of age on CD4 helper activity
    Laura Haynes; Fiscal Year: 2006
    ..abstract_text> ..
  17. Polarity of Redox Control and Risk of Injury in the Alveolar Epithelium
    Dean P Jones; Fiscal Year: 2010
    ..The results of these proposed studies will provide an unprecedented knowledge concerning the subcellular compartmentalization of oxidative stress in the lung. ..
  18. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  19. FLAGELLIN GLYCOSYLATION AND VIRULENCE OF P. AEROGINOSA
    Reuben Ramphal; Fiscal Year: 2005
    ..The existence of a central gene product involved in these could prove to be of great significance in controlling virulence. ..
  20. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  21. PCR assays to detect individual pneumococcal serotypes
    LORRY RUBIN; Fiscal Year: 2006
    ..Furthermore, they will be critical for determining the effects of current and future pneumococcal vaccines on serotype-specific carriage. ..
  22. HOME HYGIENE INTERVENTION
    Elaine Larson; Fiscal Year: 2002
    ..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
  23. Interdisciplinary Research:Antimicrobial Resistance(RMI)
    Elaine Larson; Fiscal Year: 2006
    ..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
  24. Noninvasive breath condensate: ARDS risk in alcoholics
    Lou Ann Brown; Fiscal Year: 2006
    ..abstract_text> ..
  25. Aging and Immunity Workshop
    Laura Haynes; Fiscal Year: 2004
    ..In this proposal, we are specifically requesting funds to cover the basic costs to allow five junior investigators to attend the workshop, with the goal of fostering the next generation of immunologists in this field. ..
  26. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  27. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2007
    ..abstract_text> ..
  28. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. T LYMPHOCYTE SUBSETS AND HOST DEFENSE AGAINST P CARINII
    JUDD SHELLITO; Fiscal Year: 2001
    ..The mice will then be inoculated with P. carinii organisms and assayed for clearance of infection. ..
  30. Staff Hand Hygiene and Nosocomial Infections in Neonates
    Elaine Larson; Fiscal Year: 2003
    ....
  31. Type II secretion system of P. aeruginosa in acute lung infection
    Reuben Ramphal; Fiscal Year: 2010
    ..We wish to examine which of the many known toxins are involved in death and to explore new methods to block secretion of the toxins that may eventually be useful for therapy. ..