escherichia coli infections

Summary

Summary: Infections with bacteria of the species ESCHERICHIA COLI.

Top Publications

  1. pmc Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
    David A Rasko
    University of Maryland School of Medicine, Institute for Genome Sciences and Department of Microbiology, Baltimore, USA
    N Engl J Med 365:709-17. 2011
  2. pmc Diarrheagenic Escherichia coli
    J P Nataro
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Clin Microbiol Rev 11:142-201. 1998
  3. ncbi Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany
    Christina Frank
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1771-80. 2011
  4. ncbi Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
    Martina Bielaszewska
    Institute for Hygiene and the National Consulting Laboratory for Haemolytic Uraemic Syndrome, University of Munster, Munster, Germany
    Lancet Infect Dis 11:671-6. 2011
  5. pmc The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak
    Helge Karch
    Institute of Hygiene, University Munster, Germany
    EMBO Mol Med 4:841-8. 2012
  6. ncbi Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
    Phillip I Tarr
    Division of Gastroenterology, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Lancet 365:1073-86. 2005
  7. pmc Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology
    Alexander Mellmann
    Institute of Hygiene, University Munster, Munster, Germany
    PLoS ONE 6:e22751. 2011
  8. pmc Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15
    Teresa M Coque
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Emerg Infect Dis 14:195-200. 2008
  9. ncbi Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain
    Benjamin A Rogers
    The University of Queensland, UQ Centre for Clinical Research, Herston, 4006, Brisbane, Australia
    J Antimicrob Chemother 66:1-14. 2011
  10. ncbi Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise
    J R Johnson
    VA Medical Center, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Infect Dis 181:261-72. 2000

Research Grants

Detail Information

Publications311 found, 100 shown here

  1. pmc Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
    David A Rasko
    University of Maryland School of Medicine, Institute for Genome Sciences and Department of Microbiology, Baltimore, USA
    N Engl J Med 365:709-17. 2011
    ..coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli...
  2. pmc Diarrheagenic Escherichia coli
    J P Nataro
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Clin Microbiol Rev 11:142-201. 1998
    ..coli strains and describes how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens...
  3. ncbi Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany
    Christina Frank
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1771-80. 2011
    ..The consumption of sprouts was identified as the most likely vehicle of infection...
  4. ncbi Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study
    Martina Bielaszewska
    Institute for Hygiene and the National Consulting Laboratory for Haemolytic Uraemic Syndrome, University of Munster, Munster, Germany
    Lancet Infect Dis 11:671-6. 2011
    ..We analysed virulence profiles and relevant phenotypes of outbreak isolates recovered in our laboratory...
  5. pmc The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak
    Helge Karch
    Institute of Hygiene, University Munster, Germany
    EMBO Mol Med 4:841-8. 2012
    ..Several conclusions, which will have impact on future potential E. coli outbreaks, are outlined here...
  6. ncbi Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
    Phillip I Tarr
    Division of Gastroenterology, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Lancet 365:1073-86. 2005
    ..The vascular injury leading to HUS is likely to be well under way by the time infected patients seek medical attention for diarrhoea. The best way to prevent HUS is to prevent primary infection with Shiga-toxin-producing bacteria...
  7. pmc Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology
    Alexander Mellmann
    Institute of Hygiene, University Munster, Munster, Germany
    PLoS ONE 6:e22751. 2011
    ..In conclusion, rapid next-generation technologies facilitated prospective whole genome characterization in the early stages of an outbreak...
  8. pmc Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15
    Teresa M Coque
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Emerg Infect Dis 14:195-200. 2008
    ..Most plasmids contained blaOXA-1, aac(6')-Ib-cr, and blaTEM-1. Worldwide dissemination of CTX-M-15 seems to be determined by clonal complexes ST131 and ST405 and multidrug-resistant IncFII plasmids...
  9. ncbi Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain
    Benjamin A Rogers
    The University of Queensland, UQ Centre for Clinical Research, Herston, 4006, Brisbane, Australia
    J Antimicrob Chemother 66:1-14. 2011
    ..Phenotypic detection of the ST131 clone is not possible and DNA-based techniques, including MLST and PCR, are described...
  10. ncbi Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise
    J R Johnson
    VA Medical Center, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Infect Dis 181:261-72. 2000
    ..These findings provide novel insights into the VFs of extraintestinal pathogenic E. coli and demonstrate the new PCR assay's utility for molecular epidemiological studies...
  11. ncbi German outbreak of Escherichia coli O104:H4 associated with sprouts
    Udo Buchholz
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
    N Engl J Med 365:1763-70. 2011
    ..A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May 2011. The source of infection was undetermined...
  12. pmc Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC)
    Elzbieta Brzuszkiewicz
    Göttingen Genomics Laboratory, Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstr 8, 37077, Gottingen, Germany
    Arch Microbiol 193:883-91. 2011
    ....
  13. pmc Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011
    Yonatan H Grad
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:3065-70. 2012
    ..coli outbreak populations, or uneven distribution of diversity in the seed populations that led to each outbreak...
  14. pmc Genomic comparison of Escherichia coli O104:H4 isolates from 2009 and 2011 reveals plasmid, and prophage heterogeneity, including shiga toxin encoding phage stx2
    Sanaa A Ahmed
    Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
    PLoS ONE 7:e48228. 2012
    ..coli O104:H4 strains probably occurred more than once, or that the current outbreak isolates may be the result of a recent transfer of a new stx2 phage element into a pre-existing stx2-positive genetic background...
  15. pmc Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study
    Jan Menne
    Medical School Hannover, Hannover, Germany
    BMJ 345:e4565. 2012
    ..To evaluate the effect of different treatment strategies on enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome...
  16. ncbi Escherichia coli O157
    Hugh Pennington
    University of Aberdeen, Aberdeen, UK
    Lancet 376:1428-35. 2010
    ....
  17. pmc Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982-2002
    Josefa M Rangel
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 11:603-9. 2005
    ..3%) laboratory-related. The food vehicle for 75 (41%) foodborne outbreaks was ground beef, and for 38 (21%) outbreaks, produce...
  18. ncbi Extended-spectrum β-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors
    Jan A J W Kluytmans
    Laboratory for Medical Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands
    Clin Infect Dis 56:478-87. 2013
    ..Now, we have extended the analysis with plasmid replicons, virulence factors, and highly discriminatory genomic profiling methods...
  19. ncbi High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    Arlette Darfeuille-Michaud
    Pathogenie Bacterienne Intestinale, Laboratoire de Bacteriologie, Universite d Auvergne, Clermont Ferrand, France
    Gastroenterology 127:412-21. 2004
    ..This study was performed to assess the prevalence of AIEC associated with intestinal mucosa of patients with CD, ulcerative colitis (UC), and of controls...
  20. ncbi Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptoms
    Alexander W Friedrich
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Wurzburg, Germany
    J Infect Dis 185:74-84. 2002
    ..stx2c-positive STEC isolates can cause HUS, but the presence of stx2d or stx2e may predict a milder disease with a minimal risk of HUS...
  21. pmc Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum beta-lactamases: a prospective study with Swedish volunteers
    Thomas Tängdén
    Section of Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Antimicrob Agents Chemother 54:3564-8. 2010
    ..Considering the high acquisition rate of 24%, it is obvious that global efforts are needed to meet the emergence and spread of CTX-M enzymes and other antimicrobial resistances...
  22. ncbi Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
    N T Perna
    Genome Center of Wisconsin, and Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA
    Nature 409:529-33. 2001
    ..These include candidate virulence factors, alternative metabolic capacities, several prophages and other new functions--all of which could be targets for surveillance...
  23. ncbi Shiga toxin-producing Escherichia coli: an overview
    C L Gyles
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Anim Sci 85:E45-62. 2007
    ..Studies aimed at understanding factors that affect carriage and shedding of STEC by cattle and factors that contribute to development of disease in humans are considered to be important in achieving this objective...
  24. ncbi Molecular mechanisms of Escherichia coli pathogenicity
    Matthew A Croxen
    Michael Smith Laboratories, The University of British Columbia, 301 2185 East Mall, Vancouver, British Columbia, V6T 1Z4, Canada
    Nat Rev Microbiol 8:26-38. 2010
    ..In this Review, we focus on the recent advances in our understanding of the different pathogenic mechanisms that are used by various E. coli pathovars and how they cause disease in humans...
  25. pmc Association of genomic O island 122 of Escherichia coli EDL 933 with verocytotoxin-producing Escherichia coli seropathotypes that are linked to epidemic and/or serious disease
    Mohamed A Karmali
    Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario, Canada
    J Clin Microbiol 41:4930-40. 2003
    ..0001)...
  26. ncbi The Ins and Outs of siderophore mediated iron uptake by extra-intestinal pathogenic Escherichia coli
    Amélie Garenaux
    INRS Institut Armand Frappier, 531 Boul des Prairies, Laval, Quebec, Canada H7V 1B7
    Vet Microbiol 153:89-98. 2011
    ....
  27. pmc Genome sequencing of environmental Escherichia coli expands understanding of the ecology and speciation of the model bacterial species
    Chengwei Luo
    Center for Bioinformatics and Computational Genomics, School of Biology, and School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 108:7200-5. 2011
    ..They also have important implications for reliable diagnosis and regulation of pathogenic E. coli and for the coliform cell-counting test...
  28. pmc Insights into a multidrug resistant Escherichia coli pathogen of the globally disseminated ST131 lineage: genome analysis and virulence mechanisms
    Makrina Totsika
    School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Australia
    PLoS ONE 6:e26578. 2011
    ..We conclude that E. coli ST131 is a geographically widespread, antibiotic resistant clone that has the capacity to produce numerous virulence factors associated with UTI...
  29. pmc Molecular mechanisms that mediate colonization of Shiga toxin-producing Escherichia coli strains
    Mauricio J Farfan
    Centro de Estudios Moleculares, Departamento de Pediatria, Hospital Dr Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Infect Immun 80:903-13. 2012
    ....
  30. ncbi Escherichia coli sequence type ST131 as the major cause of serious multidrug-resistant E. coli infections in the United States
    James R Johnson
    Infectious Diseases, VA Medical Center, Minneapolis, MN 55417, USA
    Clin Infect Dis 51:286-94. 2010
    ..Escherichia coli sequence type ST131 (O25:H4), associated with the CTX-M-15 extended-spectrum beta-lactamase, has emerged internationally as a multidrug-resistant pathogen but has received little attention in the United States...
  31. ncbi Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains
    M A Leverstein-Van Hall
    Department of Medical Microbiology, University Medical Centre Utrecht, The Netherlands
    Clin Microbiol Infect 17:873-80. 2011
    ..coli genotypes also present in human samples. These findings are suggestive for transmission of ESBL genes, plasmids and E. coli isolates from poultry to humans, most likely through the food chain...
  32. ncbi Molecular epidemiology of Escherichia coli producing CTX-M beta-lactamases: the worldwide emergence of clone ST131 O25:H4
    Gisele Peirano
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Int J Antimicrob Agents 35:316-21. 2010
    ....
  33. ncbi Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a meta-analysis
    Nasia Safdar
    Department of Medicine, University of Wisconsin Medical School and University of Wisconsin Hospital and Clinics, Madison, WI 53792 5158, USA
    JAMA 288:996-1001. 2002
    ..However, other larger studies have reported a protective effect or no association...
  34. ncbi Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements
    Alexander R C Wong
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 80:1420-38. 2011
    ....
  35. ncbi The non-O157 shiga-toxigenic (verocytotoxigenic) Escherichia coli; under-rated pathogens
    Karl A Bettelheim
    Crit Rev Microbiol 33:67-87. 2007
    ..The animal host-specificity of these STEC is also reviewed. In conclusion some methods of improving isolation of these pathogens is addressed...
  36. ncbi Non-O157 Shiga toxin-producing Escherichia coli infections in the United States, 1983-2002
    John T Brooks
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 192:1422-9. 2005
    ..Non-O157 STEC contribute to this burden of illness but have been underrecognized as a result of diagnostic limitations and inadequate surveillance...
  37. ncbi Super-shedding and the link between human infection and livestock carriage of Escherichia coli O157
    Margo Chase-Topping
    Centre for Infectious Diseases, University of Edinburgh, Kings Buildings, Edinburgh, EH9 3JT, UK
    Nat Rev Microbiol 6:904-12. 2008
    ..More generally, epidemiological evidence suggests that super-shedding might be important in other bacterial and viral infections...
  38. pmc Comparison of carbon nutrition for pathogenic and commensal Escherichia coli strains in the mouse intestine
    Andrew J Fabich
    Advanced Center for Genome Technology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Infect Immun 76:1143-52. 2008
    ..The results suggest a strategy whereby invading pathogens gain advantage by simultaneously consuming several sugars that may be available because they are not consumed by the commensal intestinal microbiota...
  39. pmc Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island
    James R Johnson
    Medical Service, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Clin Microbiol 46:3906-11. 2008
    ..This extends previous work regarding the pks island and supports investigation of the colibactin system as a potential therapeutic target...
  40. ncbi Molecular epidemiology of extraintestinal pathogenic Escherichia coli isolates from a regional cohort of elderly patients highlights the prevalence of ST131 strains with increased antimicrobial resistance in both community and hospital care settings
    Gemma Croxall
    Pathogen Research Group, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
    J Antimicrob Chemother 66:2501-8. 2011
    ..Also, to determine whether the possession of antibiotic resistance and virulence-associated genes can be linked to patient location or the clonal group of the organisms in question...
  41. pmc Risk factors for the hemolytic uremic syndrome in children infected with Escherichia coli O157:H7: a multivariable analysis
    Craig S Wong
    Department of Pediatrics, Division of Nephrology, University of New Mexico Children s Hospital, Albuquerque, USA
    Clin Infect Dis 55:33-41. 2012
    ..Escherichia coli O157:H7 is the leading cause of hemolytic uremic syndrome (HUS). Risk factors for development of this complication warrant identification...
  42. ncbi The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak
    Tim Magnus
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Brain 135:1850-9. 2012
    ..coli O104:H4 outbreak was surprisingly good. Magnetic resonance imaging and neuropathological findings point to a mixed toxic and inflammatory pathomechanism leading to largely reversible damage of neuronal function...
  43. pmc Risk factors and prognosis of nosocomial bloodstream infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, and Departamento de Medicina, Universidad de Seville, Avda Dr Fedriani, 3, Seville 41009, Spain
    J Clin Microbiol 48:1726-31. 2010
    ..The previous use of oxyimino-beta-lactams was the only modifiable risk factor found. Resistance to drugs other than penicillins and cephalosporins was associated with increased mortality...
  44. ncbi Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem
    Thomas A Russo
    Division of Infectious Diseases, Department of Medicine and Microbiology, The Center for Microbial Pathogenesis, VA Medical Center, University at Buffalo, Buffalo, NY 14214 3001, USA
    Microbes Infect 5:449-56. 2003
    ..coli. New treatments and prevention measures will be needed for improved outcomes and a diminished disease burden...
  45. ncbi Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006
    L Hannah Gould
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:1480-5. 2009
    ..We evaluated the age-specific rate of HUS and death among persons with STEC O157 infection and the risk factors associated with developing HUS...
  46. ncbi LEEways: tales of EPEC, ATEC and EHEC
    M Alexander Schmidt
    Institut für Infektiologie Zentrum für Molekularbiologie der Entzündung ZMBE, Westfalische Wilhelms Universitat Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    Cell Microbiol 12:1544-52. 2010
    ..coli during infection...
  47. ncbi Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Seville, Spain
    Clin Infect Dis 50:40-8. 2010
    ..We investigated the prevalence and risk factors for COBSI due to ESBLEC, and described their clinical features and the impact of COBSI caused by ESBLEC on 14-day mortality...
  48. pmc Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans
    P Boerlin
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 37:497-503. 1999
    ....
  49. pmc Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
    J C Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    Clin Microbiol Rev 11:450-79. 1998
    ..This, in turn, has created a potential window of opportunity for future therapeutic intervention...
  50. ncbi Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    Helen M Martin
    Department of Medicine, Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 127:80-93. 2004
    ..This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria, particularly Escherichia coli, in these conditions...
  51. ncbi Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies
    John M Fairbrother
    The Escherichia coli Laboratory, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, Saint Hyacinthe, QC, Canada J2S 2M2
    Anim Health Res Rev 6:17-39. 2005
    ..To date, not a single strategy has proved to be totally effective and it is probable that the most successful approach on a particular farm will involve a combination of diet modification and other preventive measures...
  52. pmc Pathogenomics of the virulence plasmids of Escherichia coli
    Timothy J Johnson
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Ave, 205 Veterinary Science, Saint Paul, MN 55108, USA
    Microbiol Mol Biol Rev 73:750-74. 2009
    ..coli pathotypes being compared in an effort to understand the evolution of these plasmid types and define their core and accessory components...
  53. pmc Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention
    Firdausi Qadri
    International Centre for Diarrhoeal Disease Research, Bangladesh
    Clin Microbiol Rev 18:465-83. 2005
    ..Increases in antimicrobial resistance will dictate the drugs used for the treatment of traveler's diarrhea. Efforts need to be made to improve our understanding of the worldwide importance of ETEC...
  54. ncbi Infection by Shiga toxin-producing Escherichia coli: an overview
    Mohamed A Karmali
    Laboratory for Foodborne Zoonoses, Health Canada, 110 Stone Road West, Guelph, Ontario, Canada, N1G 3W4
    Mol Biotechnol 26:117-22. 2004
    ..The recent sequencing of genomes of two epidemic E. coli O157 strains has revealed novel pathogenicity islands which will likely provide new insights into the virulence of these bacteria...
  55. ncbi Mosaic structure of Shiga-toxin-2-encoding phages isolated from Escherichia coli O157:H7 indicates frequent gene exchange between lambdoid phage genomes
    B K Johansen
    Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, PO Box 8146 Dep, N-0033 Oslo, Norway
    Microbiology 147:1929-36. 2001
    ..coli O157:H7 isolates were similar. There appears to have been frequent recombination of stx(2) phages with other lambdoid phages...
  56. pmc Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States
    James A Karlowsky
    Focus Technologies, Inc, 13665 Dulles Technology Drive, Suite 200, Herndon, VA 20171 4603, USA
    Antimicrob Agents Chemother 46:2540-5. 2002
    ..8 to 17.0%) from 1995 to 2001 but demonstrated considerable regional and institutional variation in 2001. Therapies other than SXT may need to be considered in some locations...
  57. ncbi Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4
    Holger Rohde
    Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    N Engl J Med 365:718-24. 2011
    ..In less than a week, these studies revealed that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance...
  58. pmc Genomic anatomy of Escherichia coli O157:H7 outbreaks
    Mark Eppinger
    Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 108:20142-7. 2011
    ..coli O157:H7 resistance and virulence phenotypes...
  59. ncbi Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial
    Andreas Greinacher
    Institut für Immunologie und Transfusionsmedizin, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Lancet 378:1166-73. 2011
    ..Some patients needed ventilatory support due to severe neurological complications, which arose 1 week after onset of enteritis, suggesting an antibody-mediated mechanism. Therefore, we aimed to assess immunoadsorption as rescue therapy...
  60. pmc Isolation and characterization of potentially pathogenic antimicrobial-resistant Escherichia coli strains from chicken and pig farms in Spain
    Pilar Cortés
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Spain
    Appl Environ Microbiol 76:2799-805. 2010
    ..coli...
  61. ncbi Verocytotoxin-producing Escherichia coli (VTEC)
    Mohamed A Karmali
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Canada
    Vet Microbiol 140:360-70. 2010
    ..Despite these efforts many scientific, technical and regulatory challenges remain in the control and prevention of VTEC-associated human illness...
  62. pmc Escherichia coli O157:H7: animal reservoir and sources of human infection
    Witold A Ferens
    Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844 3052, USA
    Foodborne Pathog Dis 8:465-87. 2011
    ..Transmission to people occurs primarily via ingestion of inadequately processed contaminated food or water and less frequently through contact with manure, animals, or infected people...
  63. ncbi Recommendations for diagnosis of shiga toxin--producing Escherichia coli infections by clinical laboratories
    L Hannah Gould
    Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, CDC, Atlanta, Georgia 30333, USA
    MMWR Recomm Rep 58:1-14. 2009
    ..Improving the diagnostic accuracy of STEC infection by clinical laboratories should ensure prompt diagnosis and treatment of these infections in patients and increase detection of STEC outbreaks in the community...
  64. pmc The type III secretion effector NleE inhibits NF-kappaB activation
    Chen Nadler
    Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    PLoS Pathog 6:e1000743. 2010
    ..In conclusion, this study describes two effectors, NleB and NleE, with no similarity to other known proteins, used by pathogens to manipulate NF-kappaB signaling pathways...
  65. pmc The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65
    Hayley J Newton
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    PLoS Pathog 6:e1000898. 2010
    ..Overall our data show that EPEC and Shigella have evolved similar T3SS-dependent means to manipulate host inflammatory pathways by interfering with the activation of selected host transcriptional regulators...
  66. pmc Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract
    M Chelsea Lane
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Proc Natl Acad Sci U S A 104:16669-74. 2007
    ..These data provide compelling evidence that wild-type UPEC express flagellin and presumably utilize flagellum-mediated motility during UTI to ascend to the upper urinary tract and disseminate within the host...
  67. pmc Virulence of Escherichia coli clinical isolates in a murine sepsis model in relation to sequence type ST131 status, fluoroquinolone resistance, and virulence genotype
    James R Johnson
    Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    Infect Immun 80:1554-62. 2012
    ..Additionally, the extensive within-ST virulence diversity suggests an opportunity to compare closely related strains to identify the responsible genetic determinants...
  68. ncbi Need for long-term follow-up in enterohemorrhagic Escherichia coli-associated hemolytic uremic syndrome due to late-emerging sequelae
    Alejandra Rosales
    Department of Pediatrics, Innsbruck Medical University, Austria
    Clin Infect Dis 54:1413-21. 2012
    ..The aim of this study was to evaluate the long-term prognosis of children with hemolytic uremic syndrome (HUS)...
  69. pmc Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection
    Thomas J Hannan
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    FEMS Microbiol Rev 36:616-48. 2012
    ..Knowledge of these checkpoints and bottlenecks is critical for our understanding of bladder infection and efforts to devise novel therapeutic strategies...
  70. pmc Comparable high rates of extended-spectrum-beta-lactamase-producing Escherichia coli in birds of prey from Germany and Mongolia
    Sebastian Guenther
    Veterinary Faculty, Institute of Microbiology and Epizootics, Freie Universitat Berlin, Berlin, Germany
    PLoS ONE 7:e53039. 2012
    ..coli and challenge the prevailing assumption that reducing human influence alone invariably leads to lower rates of antimicrobial resistance...
  71. pmc Food reservoir for Escherichia coli causing urinary tract infections
    Caroline Vincent
    McGill University, Montreal, Quebec H3A 1A2, Canada
    Emerg Infect Dis 16:88-95. 2010
    ..coli from human UTIs. This study provides strong support for the role of food reservoirs or foodborne transmission in the dissemination of E. coli causing common community-acquired UTIs...
  72. pmc Molecular epidemiology of extended-spectrum beta-lactamases among Escherichia coli isolates collected in a Swedish hospital and its associated health care facilities from 2001 to 2006
    Hong Fang
    Department of Clinical Microbiology, F68, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    J Clin Microbiol 46:707-12. 2008
    ..The study also indicated that both clonal spread of epidemic strains and transfer of transposable genetic elements might contribute to the proliferation of ESBLs...
  73. ncbi Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments
    Katie L Hopkins
    Antimicrobial Resistance and Molecular Epidemiology Unit, Laboratory of Enteric Pathogens, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5HT, UK
    Int J Antimicrob Agents 25:358-73. 2005
    ....
  74. pmc Molecular characterization and antimicrobial susceptibility testing of Escherichia coli isolates from patients with urinary tract infections in 20 Chinese hospitals
    Xiaoli Cao
    Department of General Surgery, Peking University First Hospital, Beijing 100034, China
    J Clin Microbiol 49:2496-501. 2011
    ..coli isolates, indicating the presence of a large reservoir in the community and a long-term spread of cephalosporin resistance in China...
  75. pmc Phylogenetic and genomic diversity of human bacteremic Escherichia coli strains
    Françoise Jaureguy
    INSERM UMR570, Faculte de Medecine, Universite Paris Descartes, Paris, France
    BMC Genomics 9:560. 2008
    ..A subset representative of the clonal diversity was subjected to comparative genomic hybridization (CGH) using 2,324 amplicons from the flexible gene pool of E. coli...
  76. ncbi A systematic review of outbreak and non-outbreak studies of extraintestinal pathogenic Escherichia coli causing community-acquired infections
    D B George
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec
    Epidemiol Infect 138:1679-90. 2010
    ..This review provides evidence that the epidemiology of endemic vs. epidemic ExPEC infections differs; however, study reporting quality limited epidemiological inferences...
  77. ncbi How important is patient-to-patient transmission in extended-spectrum beta-lactamase Escherichia coli acquisition
    Anthony D Harris
    Department of Epidemiology and Preventive Medicine, University of Maryland, 100 North Greene Street, Baltimore, MD 21201, USA
    Am J Infect Control 35:97-101. 2007
    ..The objective of this study was to quantify the amount of patient-to-patient transmission among patients who acquire an ESBL-producing E coli infection using perianal surveillance cultures in an intensive care unit (ICU) population...
  78. ncbi Dissemination of ST131 and ST393 community-onset, ciprofloxacin-resistant Escherichia coli clones causing urinary tract infections in Korea
    Mi Young Lee
    Asian Pacific Research Foundation for Infectious Diseases ARFID, Seoul, South Korea
    J Infect 60:146-53. 2010
    ..coli isolates causing urinary tract infections (UTIs) in Korea. In addition, the evidence of clonal spread in the community was also examined...
  79. pmc Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042
    Roy R Chaudhuri
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e8801. 2010
    ..as a cause of bacterial-mediated diarrhea. Furthermore, enteroaggregative E. coli are a predominant cause of persistent diarrhea in the developing world where infection has been associated with malnourishment and growth retardation...
  80. ncbi Survey of the incidence and aetiology of mastitis on dairy farms in England and Wales
    A J Bradley
    School of Clinical Veterinary Science, University of Bristol, Langford
    Vet Rec 160:253-7. 2007
    ..Staphylococcus aureus and coagulase-positive staphylococci together accounted for 10 per cent of the samples with high somatic cell counts; 39 per cent produced no bacterial growth...
  81. ncbi Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome
    Anne lie Ståhl
    Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Blood 117:5503-13. 2011
    ..The presence of complement on platelet-leukocyte complexes and microparticles derived from these cells suggests a role in the inflammatory and thrombogenic events that occur during HUS...
  82. ncbi Antibiotic treatment of Escherichia coli O157 infection and the risk of hemolytic uremic syndrome, Minnesota
    Kirk E Smith
    Acute Disease Investigation and Control Section, Minnesota Department of Health, St Paul, MN 55164, USA
    Pediatr Infect Dis J 31:37-41. 2012
    ..The objective of this study was to further evaluate this issue...
  83. pmc A case of hemolytic uremic syndrome caused by Escherichia coli O104:H4
    Woo Kyun Bae
    Department of Internal Medicine, Chonnam National University Medical School, Dong Gu, Gwangju 501 757, Korea
    Yonsei Med J 47:437-9. 2006
    ..We recommend that Escherichia coli O104:H4, as well as the more common O157:H7, be considered in the diagnosis of bloody diarrhea-associated HUS...
  84. ncbi Controlling injection: regulation of type III secretion in enterohaemorrhagic Escherichia coli
    Jai J Tree
    Immunity and Infection Division, The Roslin Institute and R D SVS, Chancellor s Building, University of Edinburgh, Edinburgh, EH16 4SB, UK
    Trends Microbiol 17:361-70. 2009
    ..It is evident that this repertoire of phage-related sequences results in the different levels of T3S demonstrated between strains, with implications for EHEC epidemiology and strain evolution...
  85. pmc Human intestinal tissue and cultured colonic cells contain globotriaosylceramide synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide
    Steven D Zumbrun
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Infect Immun 78:4488-99. 2010
    ..Taken together, our data suggest that Gb3 may be present in small quantities in human colonic epithelia, where it may compete for Stx binding with the more abundantly expressed glycosphingolipid Gb4...
  86. pmc Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland
    Simone Mitterhuemer
    Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU Munich, Feodor Lynen Str 25, 81377 Munich, Germany
    BMC Genomics 11:138. 2010
    Coliform bacteria are the most common etiologic agents in severe mastitis of cows. Escherichia coli infections are mostly restricted to a single udder quarter whereas neighboring quarters stay clinically inapparent, implicating the ..
  87. pmc Characterization of Saa, a novel autoagglutinating adhesin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains that are virulent for humans
    A W Paton
    Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005, Australia
    Infect Immun 69:6999-7009. 2001
    ..Interestingly, Saa produced by other STEC strains ranges in size from 460 to 534 aa as a consequence of variation in the number of repeats and/or other insertions or deletions immediately proximal to the repeat domain...
  88. pmc Urinary tract infections: new insights into a common problem
    R Kucheria
    Department of Urology, Guy s and St Thomas Hospital NHS Trust, London, UK
    Postgrad Med J 81:83-6. 2005
    ..This review discusses recent advances in the understanding of how the common pathogen, uropathogenic Escherichia coli, interacts with the host to lead to infection...
  89. ncbi Intracellular bacterial biofilm-like pods in urinary tract infections
    Gregory G Anderson
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 301:105-7. 2003
    ..The discovery of intracellular biofilm-like pods explains how bladder infections can persist in the face of robust host defenses...
  90. ncbi Enterohaemorrhagic Escherichia coli in human medicine
    Helge Karch
    Institute for Hygiene, and National Consulting Laboratory on Haemolytic Uraemic Syndrome, University Hospital Munster, Robert Koch Str 41, D 48149 Munster, Germany
    Int J Med Microbiol 295:405-18. 2005
    ..This review will focus on the microbiology, epidemiology, and pathophysiology of EHEC-associated diseases, and illustrate future challenges and opportunities for their control...
  91. pmc Enteropathogenic and enterohemorrhagic Escherichia coli virulence gene regulation
    Jay L Mellies
    Biology Department, Reed College, 3203 S E Woodstock Boulevard, Portland, OR 97202, USA
    Infect Immun 75:4199-210. 2007
  92. ncbi Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted County, Minnesota
    Daniel Z Uslan
    Divisions of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Arch Intern Med 167:834-9. 2007
    ..Despite increasing concerns about antimicrobial resistance and emerging pathogens among blood culture isolates, contemporary population-based data on the age- and sex-specific incidence of bloodstream infections (BSIs) are limited...
  93. pmc Bacteria-induced uroplakin signaling mediates bladder response to infection
    Praveen Thumbikat
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    PLoS Pathog 5:e1000415. 2009
    ..Our studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli...
  94. pmc Effects of phenotype and genotype on methods for detection of extended-spectrum-beta-lactamase-producing clinical isolates of Escherichia coli and Klebsiella pneumoniae in Norway
    Ståle Tofteland
    Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
    J Clin Microbiol 45:199-205. 2007
    ..coli strains. The relatively high proportion of ESBL-producing E. coli organisms with a low ceftazidime MIC in Norway emphasizes that cefpodoxime alone or both cefotaxime and ceftazidime should be used as substrates for ESBL detection...
  95. ncbi Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes
    E Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Clin Infect Dis 32:1162-71. 2001
    ..coli and K. pneumoniae should emphasize judicious use of all antibiotics as well as barrier precautions to reduce spread...
  96. ncbi Colibacillosis in poultry: unravelling the molecular basis of virulence of avian pathogenic Escherichia coli in their natural hosts
    Francis Dziva
    Division of Microbiology, Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Avian Pathol 37:355-66. 2008
    ..Collectively, such information provides the basis for the development or improvement of strategies to control APEC infections in the food-producing avian species...
  97. ncbi Severity of E. coli mastitis is mainly determined by cow factors
    Christian Burvenich
    Mammary gland and Mastitis Research Centre, Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 34:521-64. 2003
    ..coli, connection between endotoxins, tumor necrosis factor-alpha and nitric oxide, severity classification of E. coli mastitis, lifespan of neutrophils, host factors that influence severity, tissue damage and production loss...
  98. pmc Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function
    Xiaofei Gao
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
    PLoS Pathog 5:e1000708. 2009
    ..coli infection. We suggest that NleH may disrupt host innate immune responses by binding to a cofactor of host transcriptional complexes...
  99. pmc Escherichia coli O157:H7 survives within human macrophages: global gene expression profile and involvement of the Shiga toxins
    Katherine Poirier
    Department of Microbiology and Immunology, University of Montreal, C P 6128 Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Infect Immun 76:4814-22. 2008
    ..coli O157:H7 and human macrophages. Understanding the molecular mechanisms used by E. coli to survive within macrophages may help in the identification of targets for new therapeutic agents...
  100. ncbi Clinical relevance of shiga toxin concentrations in the blood of patients with hemolytic uremic syndrome
    Maurizio Brigotti
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Pediatr Infect Dis J 30:486-90. 2011
    ..Free toxins have never been detected in the blood of HUS patients, but they have been found on the surface of polymorphonuclear leukocytes (PMN)...
  101. ncbi Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7
    Jai J Tree
    Immunity and Infection Division, The Roslin Institute and R D SVS, University of Edinburgh, Edinburgh EH25 9RG, UK
    Mol Microbiol 80:1349-65. 2011
    ..We further demonstrate that PsrA and effectors encoded within cryptic prophage CP933-N are required for persistence in a ruminant model of colonization...

Research Grants74

  1. Maneuvering of Macrophage Function By Escherichia coli K1
    PRASADARAO V NEMANI; Fiscal Year: 2013
    ..The information from these studies will have a great impact on our understanding of the pathogenesis of E. coli meningitis and will also be useful for developing therapeutic approaches to treat and prevent meningitis. ..
  2. Photoactivated Antimicrobial Collagen
    BARBARA ANN SOLTZ; Fiscal Year: 2013
    ..Similar results were obtained for Staphylococcus aureus, MRSA, Pseudomonas aeruginosa and Escherichia coli infections. The current proposal specifically aims to further refine the use of photoactivated antimicrobial ..
  3. Emergence of E. coli sequence type ST131
    James R Johnson; Fiscal Year: 2013
    ..Emerging antimicrobial resistance in E. coli increases the risk that veterans will receive inappropriate initial antimicrobial therapy, and makes appropriate therapy more expensive, potentially toxic, and difficult to administer. ..
  4. Molecular Pathogenesis of Enterotoxigenic Escherichia coli Infections
    JAMES MICHAEL FLECKENSTEIN; Fiscal Year: 2013
    ..The long-term goal of these studies is to translate this information into rational design of a safe, effective, and broadly protective ETEC vaccine. ..
  5. Effect of Zinc in Attaching and Effacing E. coli Infection
    John K Crane; Fiscal Year: 2012
    ..Zinc inhibits the virulence of both of these groups of E. coli, and we wish to study zinc further to see if it could be used as a treatment for these infections. ..
  6. E. coli O157: H7 Vaccine Development
    Alfredo G Torres; Fiscal Year: 2012
    ..coli O157:H7, a category B pathogen for its potential use as biothreat agents in food and agriculture, and eventually to treat infections caused by other related pathogenic E. coli strains. ..
  7. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  8. A High-Performance Food Pathogen Detection Instrument
    Xiao Li Su; Fiscal Year: 2003
    ..coli O157:H7 and eventually other biological pathogens. ..
  9. Pathogenesis of EAST1 toxin in ETEC associated diarrhea disease
    Weiping Zhang; Fiscal Year: 2008
    ..The determination of virulence significance of EAST1 toxin in diarrheal disease will provide essential information to prevent or control this disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  10. Development of an additive model to study the significance of heat-labile and hea
    Weiping Zhang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. Perinatal Infection and Memory
    STACI BILBO; Fiscal Year: 2006
    ..The duration of memory impairment will also be measured, and a number of memory paradigms will be tested. ..
  12. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....
  13. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  14. AUTOTRANSPORTERS OF ENTEROBACTERIACEAE
    James Nataro; Fiscal Year: 2008
    ..This work will extend knowledge on a very common set of virulence factors and elicidate important features of the most common means of outer membrane translocation in gram negative bacteria. ..
  15. Live Vector Vaccines Against Agents of Bioterror
    James Nataro; Fiscal Year: 2007
    ..During the term of the award, we will generate a series of vaccine candidates for immediate Phase 1 human trials. ..
  16. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  18. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  20. Recombinant murine IL-10 produced in situ by H. pylori
    KATHRYN EATON; Fiscal Year: 2005
    ..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
  21. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..
  22. Dispersin from Enteroaggregative E. coli
    James Nataro; Fiscal Year: 2004
    ..Each protein will be localized and their roles addressed using mutagenesis and biochemical strategies. ..
  23. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..
  24. Regulation of Brain IL-1 & Sickness Responses Following E.coli Challenge
    John Johnson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Cellular Immune Response of Mosquitoes to Pathogens
    JULIAN HILLYER; Fiscal Year: 2003
    ..In understanding the immune response mounted by different insect species and strains toward pathogens, it may be possible to manipulate existing vectors to make the parasite/vector biologic interplay incompatible. ..
  26. Epidemiology of an uropathogenic E coli clonal group
    Lee Riley; Fiscal Year: 2003
    ..coli can be spread by contaminated ingestible vehicles, and use the data generated from this project to design long-term studies to better characterize risk factors associated with CgA infection. ..
  27. Host Cell Killing by EPEC: Central Role in Pathogenesis
    JOHN CRANE; Fiscal Year: 2005
    ..coli (RDEC-1) and rabbit EPEC (REPEC). ..
  28. MOLECULAR BASIS OF LOCALIZED ADHERENCE IN E. COLI
    Michael Donnenberg; Fiscal Year: 2009
    ..The structure of the distantly related B6 variant of bundlin will be solved to shed light on the role of sequence variation in pilus structure and immunogenicity. ..
  29. Orgin of multidrug resistant uropathogenic E. coli
    Lee Riley; Fiscal Year: 2008
    ..This knowledge should lead to the implementation of improved control of drug-resistant infectious diseases. ..
  30. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2007
    ..abstract_text> ..
  31. Mosquito-malaria interactions in the hemocoel
    JULIAN HILLYER; Fiscal Year: 2007
    ..Understanding the mechanisms used by parasites to complete their life cycle inside the vector, and the mechanisms used by the vector to kill parasites, may lead to novel transmission control strategies. [unreadable] [unreadable]..
  32. URINARY TRACT INFECTIONS--IMMUNE BASIS OF SUSCEPTIBILITY
    WALTER HOPKINS; Fiscal Year: 2003
    ....
  33. The eae Gene Cluster of Enteropathogenic E.coli
    Michael Donnenberg; Fiscal Year: 2007
    ..The significance of this work is that it will lead to a better understanding of how bacteria inject proteins into host cells and interfere with pathways that protect the cells from death and maintain barrier function. ..
  34. Nuclease-Resistant Aptamers for Anthrax Opsonization
    John Bruno; Fiscal Year: 2004
    ..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..
  35. Role of E. coli Virulence Factors in Chronic Prostate Infection and Inflammation
    WALTER HOPKINS; Fiscal Year: 2008
    ..coli genes play a direct or indirect role in development of prostatic lesions. Results of these studies can lead to new methods to prevent or treat chronic bacterial prostatitis. [unreadable] [unreadable] [unreadable]..
  36. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen B Pruett; Fiscal Year: 2010
    ..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
  37. Genomics of Susceptibility to Urinary Tract Infections
    WALTER HOPKINS; Fiscal Year: 2007
    ..coli strains or non-E, coil bacteria. These objectives will be accomplished using a well-established mouse model of ascending UTI, genetic linkage analysis, and evaluation of resistance to uropathogens in congenic mice. ..
  38. ESCHERICHIA COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Sheng He Huang; Fiscal Year: 2007
    ..To further characterize the role of IbeABP in E. coil K1 invasion of human BMEC. (3). To determine how E. coil K1 invasion gene expression is regulated by the IbeR and environmental signals (glucose and oxygen tension). ..
  39. Rural Trial of Clinic Order Entry with Decision Support
    Matthew Samore; Fiscal Year: 2006
    ..The cost impact of the intervention will be measured to allow a comprehensive assessment of the value of this HIT. [unreadable] [unreadable]..
  40. Effect of Zinc in Enteropathogenic E. coli Infection
    JOHN CRANE; Fiscal Year: 2006
    ..abstract_text> ..
  41. MOLECULAR BIOLOGY OF INFECTION WITH M TUBERCULOSIS
    Lee Riley; Fiscal Year: 2002
    ..In addition, these studies may identify several potential targets for new chemotherapeutic agents or vaccine candidates. ..
  42. Alcohol, apoptosis and lung opportunistic infection
    NYMPHA D SOUZA; Fiscal Year: 2007
    ..abstract_text> ..
  43. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2005
    ....
  44. Evolution of Antibiotic Resistance in Enteric Bacteria
    Margaret Riley; Fiscal Year: 2009
    ..abstract_text> ..
  45. In vivo regulation of M. tuberculosis cell wall lipids
    Lee W Riley; Fiscal Year: 2010
    ..tuberculosis and granulomas may contribute to our understanding of the mechanism of persistence of M. tuberculosis that could lead to new tests to differentiate active TB from latent TB infection. ..
  46. Development of killed vaccine for Vibrio cholerae O139
    Jan Holmgren; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  47. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
  48. MOLECULAR EVOLUTION OF ENTERIC BACTERIOCINS
    Margaret Riley; Fiscal Year: 2002
    ..we gain regarding the natural role of bacteriocins, and the defenses raised against them within bacterial communities, can be directly applied to the rational application of novels antimicrobials to human health issues ..
  49. Type IV Pilins as Vaccines against Bioterrorism Threats
    Michael Donnenberg; Fiscal Year: 2004
    ....
  50. Evolution of Stress-Induced Bacterial Toxins
    Margaret A Riley; Fiscal Year: 2010
    ....
  51. New Nosocomial Interventions to Decrease Antimicrobial Resistance Transmission
    Anthony Harris; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. Enteropathogenic and Toxigenic E.coli Interactions
    JOHN CRANE; Fiscal Year: 2004
    ..abstract_text> ..
  53. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
  54. Gene expression in commensal tsetse symbionts
    Brian Weiss; Fiscal Year: 2007
    ..These 'paratransgenic' flies and their offspring will then be monitored for changes in fitness, stability of recombinant protein expression and trypanosome vectorial capacity. ..
  55. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
  56. Immunomodulation in infectious diarrhea
    Jan Michael Klapproth; Fiscal Year: 2007
    ....
  57. ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSIS
    Lee Riley; Fiscal Year: 2001
    ....
  58. Therapeutic vaccine against tuberculosis
    Lee Riley; Fiscal Year: 2006
    ..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
  59. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  61. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  62. Host Responses to E. Coli Urinary Tract Infection
    DAVID HUNSTAD; Fiscal Year: 2008
    ....
  63. Targeting the E. coli chaperone SurA in recurrent UTI
    DAVID HUNSTAD; Fiscal Year: 2008
    ..This proposal identifies a new target for interrupting the cycle of recurrent urinary tract infection. [unreadable] [unreadable]..
  64. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
  65. E. coli invasion of brain endothelial cells
    Kwang Kim; Fiscal Year: 2008
    ..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
  66. UREASE AND GENE EXPRESSION OF HELICOBACTER PYLORI
    HARRY MOBLEY; Fiscal Year: 2008
    ..The long-term goals of the study are to understand the mechanism by which H. pylori can colonize the gastric mucosa and to identity more effective targets for therapeutic intervention. [unreadable] [unreadable]..
  67. GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2002
    ..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
  68. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
  69. E. COLI BINDING TO BRAIN ENDOTHELIAL CELLS
    Kwang Kim; Fiscal Year: 2003
    ....
  70. Development of a Urea Biosensor Using the UreR Protein
    HARRY MOBLEY; Fiscal Year: 2004
    ..abstract_text> ..
  71. Genome-wide screening of E. coli for bacteremia
    Kwang Kim; Fiscal Year: 2007
    ..coli bacteremia should help in development of preventive measures such as vaccines against E. coli bacteremia. [unreadable] [unreadable] [unreadable]..