bacillary dysentery

Summary

Summary: DYSENTERY caused by gram-negative rod-shaped enteric bacteria (ENTEROBACTERIACEAE), most often by the genus SHIGELLA. Shigella dysentery, Shigellosis, is classified into subgroups according to syndrome severity and the infectious species. Group A: SHIGELLA DYSENTERIAE (severest); Group B: SHIGELLA FLEXNERI; Group C: SHIGELLA BOYDII; and Group D: SHIGELLA SONNEI (mildest).

Top Publications

  1. pmc Global burden of Shigella infections: implications for vaccine development and implementation of control strategies
    K L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Bull World Health Organ 77:651-66. 1999
  2. pmc Trend and disease burden of bacillary dysentery in China (1991-2000)
    Xuan Yi Wang
    International Vaccine Institute, Seoul, Republic of Korea
    Bull World Health Organ 84:561-8. 2006
  3. ncbi Shigellosis
    Swapan Kumar Niyogi
    National Institute of Cholera and Enteric Diseases P 33, C I T Road, Scheme XM, Beliaghata Kolkata 700 010, India
    J Microbiol 43:133-43. 2005
  4. ncbi A hybrid model for short-term bacillary dysentery prediction in Yichang City, China
    Weirong Yan
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Jpn J Infect Dis 63:264-70. 2010
  5. pmc The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes
    Dong Wook Kim
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 389, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Proc Natl Acad Sci U S A 102:14046-51. 2005
  6. ncbi Bacillary dysentery and meteorological factors in northeastern China: a historical review based on classification and regression trees
    Peng Guan
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
    Jpn J Infect Dis 61:356-60. 2008
  7. pmc Investigating the effects of climate variations on bacillary dysentery incidence in northeast China using ridge regression and hierarchical cluster analysis
    Desheng Huang
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, PR China
    BMC Infect Dis 8:130. 2008
  8. pmc A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology
    Lorenz von Seidlein
    International Vaccine Institute, Seoul, Korea
    PLoS Med 3:e353. 2006
  9. pmc Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam
    Dinh Thiem Vu
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Clin Microbiol 42:2031-5. 2004
  10. pmc Weather and the transmission of bacillary dysentery in Jinan, northern China: a time-series analysis
    Ying Zhang
    Discipline of Public Health, University of Adelaide, Adelaide, South Australia
    Public Health Rep 123:61-6. 2008

Detail Information

Publications220 found, 100 shown here

  1. pmc Global burden of Shigella infections: implications for vaccine development and implementation of control strategies
    K L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Bull World Health Organ 77:651-66. 1999
    ..Innovative strategies, including development of vaccines against the most common serotypes, could provide substantial benefits...
  2. pmc Trend and disease burden of bacillary dysentery in China (1991-2000)
    Xuan Yi Wang
    International Vaccine Institute, Seoul, Republic of Korea
    Bull World Health Organ 84:561-8. 2006
    We aimed to determine the burden of bacillary dysentery in China, its cross-regional variations, trends in morbidity and mortality, the causative bacterial species and antimicrobial resistance patterns.
  3. ncbi Shigellosis
    Swapan Kumar Niyogi
    National Institute of Cholera and Enteric Diseases P 33, C I T Road, Scheme XM, Beliaghata Kolkata 700 010, India
    J Microbiol 43:133-43. 2005
    ..Travellers from developed to developing regions and soldiers serving under field conditions are also at an increased risk to develop shigellosis...
  4. ncbi A hybrid model for short-term bacillary dysentery prediction in Yichang City, China
    Weirong Yan
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Jpn J Infect Dis 63:264-70. 2010
    b>Bacillary dysentery is still a common and serious public health problem in China...
  5. pmc The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes
    Dong Wook Kim
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 389, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Proc Natl Acad Sci U S A 102:14046-51. 2005
    ..This finding indicates that OspG negatively controls the host innate response induced by S. flexneri upon invasion of the epithelium...
  6. ncbi Bacillary dysentery and meteorological factors in northeastern China: a historical review based on classification and regression trees
    Peng Guan
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
    Jpn J Infect Dis 61:356-60. 2008
    The relationship between the incidence of bacillary dysentery and meteorological factors was investigated...
  7. pmc Investigating the effects of climate variations on bacillary dysentery incidence in northeast China using ridge regression and hierarchical cluster analysis
    Desheng Huang
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, PR China
    BMC Infect Dis 8:130. 2008
    The effects of climate variations on bacillary dysentery incidence have gained more recent concern. However, the multi-collinearity among meteorological factors affects the accuracy of correlation with bacillary dysentery incidence.
  8. pmc A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology
    Lorenz von Seidlein
    International Vaccine Institute, Seoul, Korea
    PLoS Med 3:e353. 2006
    ..We conducted a prospective, population-based study in six Asian countries to gain a better understanding of the current disease burden, clinical manifestations, and microbiology of shigellosis in Asia...
  9. pmc Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam
    Dinh Thiem Vu
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Clin Microbiol 42:2031-5. 2004
    ..The clinical presentation of shigellosis may be directly related to the bacterial load...
  10. pmc Weather and the transmission of bacillary dysentery in Jinan, northern China: a time-series analysis
    Ying Zhang
    Discipline of Public Health, University of Adelaide, Adelaide, South Australia
    Public Health Rep 123:61-6. 2008
    This article aims to quantify the relationship between weather variations and bacillary dysentery in Jinan, a city in northern China with a temperate climate, to reach a better understanding of the effect of weather variations on enteric ..
  11. pmc Estimating the burden of shigellosis in Thailand: 36-month population-based surveillance study
    Pornthip Chompook
    Chiang Rai Regional Hospital, Chiang Rai Province, Ministry of Public Health, Thailand
    Bull World Health Organ 83:739-46. 2005
    ..To estimate incidence of shigellosis in the Kaengkhoi district, Saraburi Province, Thailand...
  12. ncbi Climate variations and bacillary dysentery in northern and southern cities of China
    Ying Zhang
    Department of Public Health, University of Adelaide, Level 9, 10 Pulteney Street, Adelaide, SA5005, Australia
    J Infect 55:194-200. 2007
    This paper was aimed at examining the relationship between meteorological variables and bacillary dysentery in different climatic and geographic areas in China.
  13. ncbi Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, INSERM U786, Institut Pasteur 25, rue du Dr Roux, Paris, France
    Immunol Cell Biol 85:119-29. 2007
    ..This complex and aggressive process accounts for the symptoms of bacillary dysentery. The so-called invasive phenotype of Shigella is linked to expression of a type III secretory system (TTSS) ..
  14. pmc Identification of shuA, the gene encoding the heme receptor of Shigella dysenteriae, and analysis of invasion and intracellular multiplication of a shuA mutant
    M Mills
    Department of Microbiology and Institute for Cellular and Molecular Biology, University of Texas, Austin 78712, USA
    Infect Immun 65:5358-63. 1997
    ..dysenteriae. However, shuA is not essential for invasion or multiplication within cultured Henle cells; the shuA mutant invaded and produced normal plaques in confluent cell monolayers...
  15. pmc Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis
    L h Wang
    Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Gut 53:1096-101. 2004
    The incidence of irritable bowel syndrome (IBS) or functional bowel disorders (FBD) after bacillary dysentery (BD) has not been extensively evaluated, and little is known of the pathogenesis of post-infective (PI) IBS...
  16. pmc Temporal shifts in the dominance of serotypes of Shigella dysenteriae from 1999 to 2002 in Dhaka, Bangladesh
    Kaisar A Talukder
    ICDDR, B Centre for Health and Population Research, Dhaka 1000, Bangladesh
    J Clin Microbiol 41:5053-8. 2003
    ..All the strains harboring the 140-MDa plasmid were positive for the ipaH gene, had Congo red binding abilities, and were positive by the Sereny test, demonstrating their invasive properties...
  17. ncbi IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri
    Abderrahman Hachani
    Laboratoire de Bactériologie Moléculaire, Universite Libre de Bruxelles ULB, Faculte de Medecine, Route de Lennik, 808, CP 614 B, 1070 Brussels, Belgium
    Microbes Infect 10:260-8. 2008
    ..The attenuated phenotype of the ipgB1 ipgB2 mutant was confirmed using a murine pulmonary model of infection and histopathology and immunochemistry studies...
  18. ncbi Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium
    Hélène d'Hauteville
    Unité de Pathogénie Microbienne Moléculaire and Institut National de la Santé et de la Recherche Médicale, Unité 389, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Immunol 168:5240-51. 2002
    ....
  19. pmc Genetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children
    C S Toro
    Laboratório de Antibióticos, Programa de Microbiología y Micología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Epidemiol Infect 133:81-6. 2005
    ..Our results show a heterogenous distribution of antibiotic-resistance determinants between S. flexneri and S. sonnei...
  20. ncbi New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies
    Doo Hee Shim
    Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea
    J Immunol 178:2476-82. 2007
    ..difficult to evaluate the protective efficacy of vaccine candidates against shigellosis, a major form of bacillary dysentery caused by Shigella spp. infection, because of the lack of suitable animal models...
  21. pmc Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery
    Fan Yang
    State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Ministry of Public Health, Beijing 100052, China
    Nucleic Acids Res 33:6445-58. 2005
    The Shigella bacteria cause bacillary dysentery, which remains a significant threat to public health...
  22. pmc Antimicrobial resistance and genetic diversity of Shigella sonnei isolates from western Ireland, an area of low incidence of infection
    Niall DeLappe
    National Salmonella Reference Laboratory, University College Hospital, Galway, Ireland
    J Clin Microbiol 41:1919-24. 2003
    ..Indistinguishable plasmid profiles in addition to indistinguishable PFGE and antibiogram types may be more suggestive of an epidemiologically relevant link between cases...
  23. pmc A changing picture of shigellosis in southern Vietnam: shifting species dominance, antimicrobial susceptibility and clinical presentation
    Ha Vinh
    The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    BMC Infect Dis 9:204. 2009
    ..Antimicrobial resistance in the genus Shigella is a constant threat, with reports of organisms in Asia being resistant to multiple antimicrobials and new generation therapies...
  24. pmc Shifting serotypes, plasmid profile analysis and antimicrobial resistance pattern of shigellae strains isolated from Kolkata, India during 1995-2000
    S Dutta
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Epidemiol Infect 129:235-43. 2002
    ..sonnei and a correlation between presence of smaller plasmids and shigellae serotypes. Hence this study reports epidemiological change of shigellae species in Kolkata, India with regard to serotypes and antibiotic resistance patterns...
  25. ncbi Detection of Shigellae from stools of dysentery patients by culture and polymerase chain reaction techniques
    M S Islam
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    J Diarrhoeal Dis Res 16:248-51. 1998
    ....
  26. ncbi Genetic relatedness of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated in south Asia
    Kaisar A Talukder
    Enteric Microbiology Laboratory, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Antimicrob Chemother 54:730-4. 2004
    ..The aim of the present study was to determine the clonal relationships of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated from south Asia, and S. dysenteriae 1 strains associated with epidemics in 1978, 1984 and 1994...
  27. ncbi CTX-M-3 extended-spectrum beta-lactamase in a Shigella sonnei clinical isolate: first report from Turkey
    Ziya Cibali Acikgoz
    Department of Microbiology and Clinical Microbiology, Fatih University School of Medicine, Ankara, Turkey
    Scand J Infect Dis 35:503-5. 2003
    ..This is the first report from Turkey of Shigella spp. producing an ESBL, and of CTX-M type enzyme...
  28. ncbi Epidemiological characterization of resistance and PCR typing of Shigella flexneri and Shigella sonnei strains isolated from bacillary dysentery cases in Southeast Brazil
    M P A Penatti
    Departamento de Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, 13081 970 Campinas, SP, Brazil
    Braz J Med Biol Res 40:249-58. 2007
    ..and non-sporulated bacilli of the Enterobacteriaceae family responsible for "Shigellosis" or bacillary dysentery, an important cause of worldwide morbidity and mortality...
  29. pmc A recurring outbreak of Shigella sonnei among traditionally observant Jewish children in New York City: the risks of daycare and household transmission
    V Garrett
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiol Infect 134:1231-6. 2006
    ..Disease containment efforts should focus on reducing Shigella transmission in childcare settings and within homes...
  30. ncbi Extended-spectrum beta-lactamase-mediated third-generation cephalosporin resistance in Shigella isolates in Bangladesh
    Mahbubur Rahman
    J Antimicrob Chemother 54:846-7. 2004
  31. pmc Altering trends in the dominance of Shigella flexneri serotypes and emergence of serologically atypical S. flexneri strains in Dhaka, Bangladesh
    K A Talukder
    International Centre for Diarrhoeal Diseases Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 39:3757-9. 2001
    ..flexneri 2b dominating (23.2%). Of the 56 untypeable strains which showed invasive properties, 17 were serologically atypical and the remaining 39 belonged to a new serotype...
  32. ncbi Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses
    Jun Okuda
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8039, Japan
    Biochem Biophys Res Commun 333:531-9. 2005
    ..The results indicate that IpaH9.8 plays a role in Shigella infection to optimize the host inflammatory responses, thus facilitating bacterial colonization within the host epithelial cells...
  33. pmc Outbreak of dysentery associated with ceftriaxone-resistant Shigella sonnei: First report of plasmid-mediated CMY-2-type AmpC beta-lactamase resistance in S. sonnei
    I Fei Huang
    Department of Pediatrics, Veterans General Hospital Kaohsiung, 386, Ta Chung 1st Road, Kaohsiung, Taiwan
    J Clin Microbiol 43:2608-12. 2005
    ..identified among Shigella sonnei isolates resistant to ceftriaxone and obtained after an outbreak of bacillary dysentery in Taiwan...
  34. pmc Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research Bangladesh, Centre for Health and Population Research, Dhaka 1212, Bangladesh
    Proc Natl Acad Sci U S A 103:9178-83. 2006
    ....
  35. ncbi Emergence of CTX-M-type beta-lactam resistance in Shigella spp. in Hong Kong
    Terence Kin Man Cheung
    Int J Antimicrob Agents 25:350-2. 2005
  36. ncbi Antimicrobial susceptibility of Shigella isolates in eight Asian countries, 2001-2004
    Chen Yen Kuo
    Department of Pediatrics, Chang Gung Children s Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
    J Microbiol Immunol Infect 41:107-11. 2008
    ..Because of increasing trends towards drug resistance, this study was undertaken to monitor local resistance patterns of Shigella isolates from 8 Asian countries...
  37. ncbi Antibiotic resistance and sero-groups of shigella among paediatric out-patients in southwest Ethiopia
    A Mache
    Department of Medical Microbiology and Parasitology, Jimma University, Ethiopia
    East Afr Med J 78:296-9. 2001
    ..3%) whileleast resistance was observed to gentamicin (1.3%), polymyxin B (3.9%) and nalidixic acid (6.5%). CONCLUSION: Gentamicin, polymyxin B and nalidixic acid were found to be the drugs of choice for cases related with shigellosis...
  38. ncbi Occurrence of shigellosis in the young and elderly in rural China: results of a 12-month population-based surveillance study
    Xuan Yi Wang
    International Vaccine Institute, Seoul, South Korea
    Am J Trop Med Hyg 73:416-22. 2005
    ..Widespread resistance to antibiotics adds urgency to the development and use of vaccines to control shigellosis...
  39. pmc Increasing spectrum in antimicrobial resistance of Shigella isolates in Bangladesh: resistance to azithromycin and ceftriaxone and decreased susceptibility to ciprofloxacin
    Mahbubur Rahman
    Laboratory Sciences Division, ICDDR, B GPO Box 128, Dhaka 1000 Mohakhali, Dhaka 1212, Bangladesh
    J Health Popul Nutr 25:158-67. 2007
    ..The growing antimicrobial resistance of Shigella is worrying and mandates monitoring of resistance. Pivmecillinam or ciprofloxacin might be considered for treating shigellosis with caution...
  40. ncbi Geographic analysis of shigellosis in Vietnam
    Deok Ryun Kim
    International Vaccine Institute, SNU Research Park, San 4 8 Bongcheon 7 Dong, Kwanak gu, Seoul, Republic of Korea
    Health Place 14:755-67. 2008
    ..The disease maps can help identify high-risk areas of shigellosis that can be targeted for interventions. This approach may be useful for the selection of populations and the analysis of vaccine trials...
  41. ncbi The versatility of Shigella effectors
    Michinaga Ogawa
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Rev Microbiol 6:11-6. 2008
    ..Although bacterial strategies and mechanisms of infection vary greatly, recent studies of Shigella effectors have revealed that Shigella possess a highly evolved strategy for infection...
  42. pmc Phenotypic and genotypic characterization of provisional serotype Shigella flexneri 1c and clonal relationships with 1a and 1b strains isolated in Bangladesh
    Kaisar A Talukder
    Enteric Laboratory, Laboratory Sciences Division, International Centre for Diarrhoeal Diseases Research, Bangladesh
    J Clin Microbiol 41:110-7. 2003
    ..Furthermore, the high rate of prevalence of serotype 1c necessitates the commercial production of antibody against this subserotype to allow the determination of the actual burden of shigellosis caused by provisional serotype 1c...
  43. ncbi Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India
    Gururaja Perumal Pazhani
    1National Institute of Cholera and Enteric Diseases, Kolkata, India
    J Med Microbiol 57:856-63. 2008
    ..PFGE analysis revealed clonality among strains of S. dysenteriae types 1 and 5, S. flexneri type 2a and Shigella boydii type 12...
  44. ncbi Shigella infections
    P Shears
    Centre for Tropical Medical Microbiology, Liverpool School of Tropical Medicine
    Ann Trop Med Parasitol 90:105-14. 1996
    ..No vaccines are currently available, and prevention and control will depend on public-health improvements and improved case management...
  45. pmc The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation
    K Al-Hasani
    Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
    Infect Immun 68:2457-63. 2000
    ..SigA was at least partly responsible for the ability of S. flexneri to stimulate fluid accumulation in ligated rabbit ileal loops...
  46. ncbi Risk factors for mortality due to shigellosis: a case-control study among severely-malnourished children in Bangladesh
    J M van den Broek
    Academical Medical Centre, University of Amsterdam, The Netherlands
    J Health Popul Nutr 23:259-65. 2005
    ....
  47. pmc Clonal multidrug-resistant Shigella dysenteriae type 1 strains associated with epidemic and sporadic dysenteries in eastern India
    Gururaja Perumal Pazhani
    National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata 700 010, India
    Antimicrob Agents Chemother 48:681-4. 2004
    ..Based on the spatial and temporal spread of multidrug-resistant S. dysenteriae type 1, we predict that this clonal type may spread further in this region...
  48. ncbi Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis
    M A Salam
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Lancet 352:522-7. 1998
    ..We undertook a randomised double-blind study to test the effects of ciprofloxacin treatment in children with shigella dysentery...
  49. ncbi [Analysis on incidence of bacillary dysentery in Jinan municipality from 1951 to 2005]
    Ye Lu
    Jinan Municipal Center for Disease Control and Prevention, Jinan, China
    Zhonghua Yu Fang Yi Xue Za Zhi 42:342-4. 2008
    ..To explore the epidemic characteristics of bacterial dysentery in Jinan municipality, and to provide scientific basis for effective strategy for bacterial dysentery control...
  50. ncbi Detection of CTX-M-14 extended-spectrum beta-lactamase in Shigella sonnei isolates from China
    Zizhong Xiong
    Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
    J Infect 55:e125-8. 2007
    ..This is the first report of CTX-M-14 in S. sonnei isolates from China and it is important to closely monitor such strains...
  51. pmc Characterization of a Shiga toxin-encoding temperate bacteriophage of Shigella sonnei
    E Strauch
    Robert Koch-Institut, D-13353 Berlin, Germany
    Infect Immun 69:7588-95. 2001
    ..Our findings demonstrate that stx genes are naturally transferable and are expressed in strains of S. sonnei, which points to the continuous evolution of human-pathogenic Shigella by horizontal gene transfer...
  52. ncbi Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Santé et de la Recherche Médicale Unité 389
    J Immunol 176:1686-94. 2006
    ..with noncapsulated Gram-negative bacteria, such as Shigella, an enteroinvasive bacterium responsible for bacillary dysentery, is mainly achieved by Abs specific for the O-Ag, the polysaccharide part of the LPS, the major bacterial ..
  53. ncbi High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin
    Toshihiko Suzuki
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:4709-17. 2006
    ....
  54. ncbi [Shigellosis or bacillary dysentery]
    Xavier Nicolas
    Service de Medecine Interne et Maladies Infectieuses, Hôpital Clermont Tonnerre, Brest
    Presse Med 36:1606-18. 2007
    Shigellosis, commonly known as bacillary dysentery, is an enterobacterial disease caused by the Shigella genus, which now belongs to the Escherichia tribe, because of their genetic and phenotypic similarities. S...
  55. ncbi Aetiology of shigellosis in northern Pakistan
    Khalil Ahmed
    Cell and Molecular Biology Laboratory, School of Biological Sciences, University of the Punjab, New Campus, Lahore, Pakistan
    J Health Popul Nutr 21:32-9. 2003
    ..is high in northern Pakistan, the aetiological agents are highly resistant to chloramphenicol and ampicillin, and the antibiotic resistance is mediated by the 23-kb plasmid...
  56. ncbi Shigella and autophagy
    Michinaga Ogawa
    Department of Microbiology and Immunology, Institute of Medical Sceince, University of Tokyo, Tokyo, Japan
    Autophagy 2:171-4. 2006
    ..In this review we discuss recent discoveries regarding Shigella strategies for infecting mammalian cells, and then focus on recent studies of an elegant bacterial survival strategy against autophagic degradation...
  57. pmc Strategy for cross-protection among Shigella flexneri serotypes
    F R Noriega
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 67:782-8. 1999
    ..Furthermore, the combination vaccine conferred significant protection against challenge with S. flexneri serotypes 1b, 2b, 5b, and Y but not with serotypes 1a, 4b, or (as predicted) 6...
  58. ncbi Sensitivity and performance characteristics of a direct PCR with stool samples in comparison to conventional techniques for diagnosis of Shigella and enteroinvasive Escherichia coli infection in children with acute diarrhoea in Calcutta, India
    S Dutta
    National Institute of Cholera and Enteric Diseases, Beliaghata, Calcutta, India
    J Med Microbiol 50:667-74. 2001
    ..Moreover, this PCR assay could identify a number of untypable Shigella strains (Sh OUT), which would have remained undiagnosed had this assay not been used...
  59. pmc Epidemic strains of Shigella sonnei biotype g carrying integrons
    Christopher J McIver
    Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia
    J Clin Microbiol 40:1538-40. 2002
    ..A class 1 integron was also found in two epidemic strains. Gene cassettes within these integrons account for resistance to commonly used therapeutic agents...
  60. pmc Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion
    Gunnar N Schroeder
    ETH Zurich, Institute of Microbiology, Wolfgang Pauli Strasse 10, HCI G405, 8093 Zurich, Switzerland
    Clin Microbiol Rev 21:134-56. 2008
    ..An understanding of the molecular mechanisms underlying Shigella pathogenesis will foster the development of a safe and efficient vaccine, which, in parallel with improved hygiene, should curb infections by this widespread pathogen...
  61. pmc Phenotypic and genotypic characterization of serologically atypical strains of Shigella flexneri type 4 isolated in Dhaka, Bangladesh
    Kaisar A Talukder
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 40:2490-7. 2002
    ..This study concluded that two different clones of atypical S. flexneri type 4 exist and strongly suggests that these are new subserotypes of S. flexneri that await further serological classification...
  62. pmc Shigella dysenteriae serotype 1, Kolkata, India
    Shanta Dutta
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Emerg Infect Dis 9:1471-4. 2003
    ..dysenteriae 1 strains complicated treatment of shigellosis patients. Six strains belonging to provisional serovars of S. dysenteriae were also identified for the first time in patients hospitalized with diarrhea in Kolkata, India...
  63. ncbi Randomized comparison of azithromycin versus cefixime for treatment of shigellosis in children
    Wilma Basualdo
    Department of Pediatrics, Instituto de Medicina Tropical, Herrera 1459, Asuncion, Paraguay
    Pediatr Infect Dis J 22:374-7. 2003
  64. ncbi Shigella infection of intestinal epithelium and circumvention of the host innate defense system
    Hiroshi Ashida
    Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Curr Top Microbiol Immunol 337:231-55. 2009
    ..Gram-negative bacteria closely related to Escherichia coli, are highly adapted human pathogens that cause bacillary dysentery. Although Shigella have neither adherence factors nor flagella required for attaching or accessing the ..
  65. pmc Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nat Rev Microbiol 5:540-53. 2007
    ....
  66. ncbi Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator
    D Islam
    Laboratory Sciences Division, International Center for Diarrhoeal Disease Research, 1000 Dhaka, Bangladesh
    Nat Med 7:180-5. 2001
    ..Analyses of bacterial molecules causing the downregulation indicate Shigella plasmid DNA as one mediator...
  67. ncbi Shigellosis : challenges & management issues
    Dipika Sur
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    Indian J Med Res 120:454-62. 2004
    ..Shigellosis, also known as acute bacillary dysentery, is characterized by the passage of loose stools mixed with blood and mucus and accompanied by fever, ..
  68. ncbi Microbes and microbial toxins: paradigms for microbial-mucosal interactions III. Shigellosis: from symptoms to molecular pathogenesis
    P J Sansonetti
    Unité de Pathogénie Microbienne Moléculaire et Unité Institut National de la Santé et de la Recherche Médicale 389, Institut Pasteur, 75724 Paris Cedex 15, France
    Am J Physiol Gastrointest Liver Physiol 280:G319-23. 2001
    ..Subsequent apoptotic killing of macrophages in a caspase 1-dependent process causes the release of IL-1beta and IL-18, which accounts for the initial steps of inflammation...
  69. ncbi Multidrug-resistant Shigella dysenteriae type 1 in south Asia
    S K Bhattacharya
    National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata, India
    Lancet Infect Dis 3:755. 2003
  70. ncbi IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis
    Monique Singer
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    J Immunol 173:4197-206. 2004
    The lack of a mouse model of acute rectocolitis mimicking human bacillary dysentery in the presence of invasive Shigella is a major handicap to study the pathogenesis of the disease and to develop a Shigella vaccine...
  71. ncbi A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling
    Hiroki Iwai
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cell 130:611-23. 2007
    ..These results strongly indicate that Shigella employ special tactics to influence epithelial renewal in order to promote bacterial colonization of intestinal epithelium...
  72. ncbi Rupture of the intestinal epithelial barrier and mucosal invasion by Shigella flexneri
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Institut Pasteur, Paris, France
    Clin Infect Dis 28:466-75. 1999
    ..Once they are intracellular, bacteria multiply within the cytoplasm and move from cell to cell by an actin-dependent process...
  73. ncbi Prevalence of Shigella species and their antimicrobial resistance patterns in Eastern Nepal
    Shyamal Bhattacharya
    Department of Microbiology, B P Koirala Institute of Health Sciences, Dharan, Nepal
    J Health Popul Nutr 23:339-42. 2005
    ..dysenteriae type 1. The results suggest reconsideration of the empiric use of these antimicrobial agents for shigellosis. A further study is required to evaluate additional antimicrobial agents...
  74. ncbi Diarrhoeagenic Escherichia coli and other causes of childhood diarrhoea: a case-control study in children living in a wastewater-use area in Hanoi, Vietnam
    Bui Thi Thu Hien
    Department of Microbiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    J Med Microbiol 56:1086-96. 2007
    ..For this particular region, vaccine development strategies targeting rotavirus and Shigella are likely to be of public health benefit, whereas the role of DEC and preventive measures need to be further elaborated...
  75. ncbi Microtubule-severing activity of Shigella is pivotal for intercellular spreading
    Sei Yoshida
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Science 314:985-9. 2006
    ..Degradation of microtubules by VirA was dependent on its alpha-tubulin-specific cysteine protease-like activity. virA mutants did not move within the host cytoplasm and failed to move into adjacent cells...
  76. pmc Shigellosis linked to sex venues, Australia
    Belinda O'Sullivan
    New South Wales Health Department, New South Wales, Australia
    Emerg Infect Dis 8:862-4. 2002
    ..Of reported cases, 83% were confirmed as Shigella sonnei biotype G infections; 80% were in homosexual men. Visiting a sex venue in the 2 weeks before onset of illness was the only factor significantly associated with shigellosis...
  77. ncbi Important bacterial gastrointestinal pathogens in children: a pathogenesis perspective
    Manuel R Amieva
    Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, CA 94305 5208, USA
    Pediatr Clin North Am 52:749-77, vi. 2005
    ....
  78. ncbi Trends in population-based active surveillance for shigellosis and demographic variability in FoodNet sites, 1996-1999
    Beletshachew Shiferaw
    Oregon Department of Human Services, Office of Disease Prevention and Epidemiology, Portland, OR 97232, USA
    Clin Infect Dis 38:S175-80. 2004
    ..Compared with other age groups, the incidence was highest among children aged 1-4 years of (36.3 cases/100,000 population). Marked demographic differences were observed between infections with S. sonnei and S. flexneri...
  79. ncbi Multidrug-resistant Shigella sonnei and Salmonella enterica Serotype typhimurium isolates producing CTX-M beta-lactamases as causes of community-acquired infection in France
    M F Lartigue
    Clin Infect Dis 40:1069-70. 2005
  80. pmc Species diversity and antimicrobial resistance of Shigella spp. isolated between 2001 and 2004 from hospitalized children with diarrhoea in Kolkata (Calcutta), India
    G P Pazhani
    Department of Microbiology, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Epidemiol Infect 133:1089-95. 2005
    ..flexneri, but not in S. boydii or S. sonnei. Monitoring of antimicrobial susceptibility through a surveillance programme is recommended to select appropriate antibiotics for the effective treatment of shigellosis in this region...
  81. ncbi Genetic characterization of multidrug resistance in Shigella spp. from Japan
    Ashraf M Ahmed
    Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima 739 8528, Japan
    J Med Microbiol 55:1685-91. 2006
    ..Southern blot hybridization and conjugation experiments showed that bla(OXA-30) was located in the chromosome...
  82. pmc The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance
    Magdarina D Agtini
    National Institute of Health Research and Development, Jakarta Indonesia, Ministry of Health, Jakarta, Indonesia
    BMC Infect Dis 5:89. 2005
    ....
  83. ncbi Case management of a multidrug-resistant Shigella dysenteriae serotype 1 outbreak in a crisis context in Sierra Leone, 1999-2000
    P J Guerin
    Epicentre, 8 rue Saint Sabin, 75011 Paris, France
    Trans R Soc Trop Med Hyg 98:635-43. 2004
    ..9%. Patients who did not have signs of severity when seen by health workers were given hygiene advice and oral rehydration salts. This strategy was effective in this complex emergency...
  84. pmc Extensive genomic diversity in pathogenic Escherichia coli and Shigella Strains revealed by comparative genomic hybridization microarray
    Satoru Fukiya
    Kyowa Hakko Kogyo, Tokyo Research Laboratories, 3 6 6 Asahimachi, Machidashi, Tokyo 194 8533, Japan
    J Bacteriol 186:3911-21. 2004
    ..The data demonstrated that the CGH microarray technique is useful not only for genomic comparisons but also for phylogenic analysis of E. coli at the strain level...
  85. ncbi Post-infectious irritable bowel syndrome in patients with Shigella infection
    Sangwon Ji
    Yonsei Institute of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 20:381-6. 2005
    ..The aims of this study were to verify the role of bacterial gastroenteritis in the development of IBS and the risk factors for the development of PI-IBS. The clinical course of PI-IBS was also investigated...
  86. ncbi [The development of irritable bowel syndrome after Shigella infection: 3 year follow-up study]
    Hee Sun Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Korean J Gastroenterol 47:300-5. 2006
    ..So, we investigated the clinical course and prognosis of PI-IBS three years after shigella infection...
  87. pmc Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation
    Roger W Kramer
    Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America
    PLoS Pathog 3:e21. 2007
    ..These studies demonstrate how yeast systems biology can facilitate functional characterization of pathogenic bacterial effector proteins...
  88. pmc Characterization of Shigella strains in Iran by plasmid profile analysis and PCR amplification of ipa genes
    Shohreh Farshad
    Prof Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Nemazi Hospital, Shiraz 71937 11351, Iran
    J Clin Microbiol 44:2879-83. 2006
    ..These results also demonstrate that plasmid profile analysis is more reliable than antibiotic susceptibility pattern analysis for the identification of Shigella epidemic strains isolated in Iran...
  89. ncbi Molecular characteristics of class 1 and class 2 integrons and their relationships to antibiotic resistance in clinical isolates of Shigella sonnei and Shigella flexneri
    Jing Cao Pan
    Microbiology Laboratory, Hangzhou Center for Disease Control and Prevention Hangzhou 310006, People s Republic of China
    J Antimicrob Chemother 58:288-96. 2006
    ..To analyse the gene cassettes and determine the roles of class 1 and class 2 integrons in antibiotic-resistant strains of Shigella sonnei (n=31) and Shigella flexneri (n=33)...
  90. ncbi Fluoroquinolone-resistant Shigella dysenteriae type 1 in northeastern Bangladesh
    A Naheed
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    Lancet Infect Dis 4:607-8. 2004
  91. pmc Shigellosis: an old disease in new clothes?
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Unité INSERM 786, Institut Pasteur, Paris, France
    PLoS Med 3:e354. 2006
  92. ncbi A multi-prefectural outbreak of Shigella sonnei infections associated with eating oysters in Japan
    Jun Terajima
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Microbiol Immunol 48:49-52. 2004
    ..Isolates of S. sonnei from patients epidemiologically linked to eating contaminated oysters and from the imported oysters themselves showed an indistinguishable pulsed-field gel electrophoresis pattern and drug resistance pattern...
  93. ncbi Shigella dysenteriae type 1 with reduced susceptibility to fluoroquinolones
    K Sarkar
    Lancet 361:785. 2003
  94. pmc Part II. Analysis of data gaps pertaining to Shigella infections in low and medium human development index countries, 1984-2005
    P K Ram
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA
    Epidemiol Infect 136:577-603. 2008
    ..This review highlights the large gaps in data on the burden of Shigella infections for low human development index countries and, more specifically, for sub-Saharan Africa...
  95. pmc HIV infection as a risk factor for shigellosis
    J T Baer
    California Emerging Infections Program, San Francisco, California, USA
    Emerg Infect Dis 5:820-3. 1999
    ..Dramatically elevated rates of shigellosis in HIV-infected persons implicate HIV infection as an important risk factor for shigellosis in San Francisco...
  96. pmc "Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli
    A T Maurelli
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, MD 20814 4799, USA
    Proc Natl Acad Sci U S A 95:3943-8. 1998
    ..For example, Shigella spp., the causative agents of bacillary dysentery, differ from the closely related commensal Escherichia coli in the presence of a plasmid in Shigella that ..
  97. ncbi Prevalence of multidrug-resistant Shigella isolated in Malaysia
    Kwai Lin Thong
    J Health Popul Nutr 20:356-8. 2002
  98. ncbi [Investigation of a shigellosis outbreak in a rural zone of Senegal]
    A Diallo
    Centre IRD, BP 1386, Dakar Hann, Senegal
    Sante 11:217-9. 2001
    ..The identification of the SD1 serotype confirmed its involvement in the outbreak of shigellosis. The exact role of S. flexneri in shigellosis epidemics should be further studied...
  99. pmc ShiA abrogates the innate T-cell response to Shigella flexneri infection
    Molly A Ingersoll
    Max Planck Institute for Infection Biology, 21 22 Schumannstrasse, 10117 Berlin, Germany
    Infect Immun 74:2317-27. 2006
    Shigella spp. are the causative agent of bacillary dysentery. Infection results in acute colonic injury due to the host inflammatory response...
  100. ncbi A prolonged outbreak of Shigella sonnei infections in traditionally observant Jewish communities in North America caused by a molecularly distinct bacterial subtype
    J Sobel
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 177:1405-9. 1998
    ..sonnei caused an international outbreak involving 8 traditionally observant Jewish communities, but not neighboring populations, over a 2-year period, suggesting sustained propagation of the epidemic strain between communities...
  101. ncbi Prevalence and pattern of antimicrobial resistance of Shigella species among patients with acute diarrhoea in Karaj, Tehran, Iran
    Koorosh MoezArdalan
    National Research Department of Foodborne Diseases, Research Center of Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    J Health Popul Nutr 21:96-102. 2003
    ..1%, 3.1%, 2.0%, and 1.0% of the isolates respectively. These findings suggest that Shigella spp. may be an important aetiological agent of diarrhoea with a high rate of drug resistance in this region, which requires further study...

Research Grants27

  1. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..mortality and morbidity in Bangladesh, some of the most common water related diseases being typhoid fever, bacillary dysentery, and diarrhea...
  2. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..invasion and intercellular spread of the bacterial pathogen Shigella flexneri, the causative agent of bacillary dysentery. S...
  3. Interferon gamma-mediated restriction of Shigella flexneri replication
    Michael N Starnbach; Fiscal Year: 2013
    ..intracellular pathogen responsible for serious enteric infections, characterized by severe inflammatory bacillary dysentery. Type III-secreted effector proteins enable S...
  4. MOLECULAR GENETIC ANALYSIS OF SHIGELLA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella is the causative agent of bacillary dysentery in humans and primates. Over 200 million cases are reported annually and about 650,000 persons die of shigellosis each year...
  5. The multiple states of IpaB Shigella type III secretion
    William D Picking; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella flexneri, the causative agent of bacillary dysentery, uses a type III secretion system (T3SS) to deliver virulence proteins into host cells to promote pathogen entry into these cells...
  6. SHIGA-LIKE TOXIN OF ESCHERICHIA COLI
    ALISON O BRIEN; Fiscal Year: 1991
    ..at the molecular levels and to determine if these have essential or accessory roles in the pathogenesis of bacillary dysentery, hemorrhagic colitis, and the hemolytic uremic syndrome...
  7. Lipid raft effects on Shigella type III secretion system-based interactions
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella flexneri, the causative agent of bacillary dysentery, uses its type III secretion system (TTSS) as a conduit through which effector proteins are shuttled from bacterial to host cell ..
  8. Bacterial Pathogen Amplification & Real-Time Detection
    JACK U REN; Fiscal Year: 2003
    ..Also, the test can be used to identify the antibiotic sensitivity of the pathogen to identify genetically altered organisms. ..
  9. MOLECULAR MECHANISMS OF BACTERIAL MEDIATED APOPTOSIS
    Claudio Basilico; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Bacillary dysentery is an acute inflammatory disease of the colon caused by the Gram negative bacteria Shigella...
  10. GENETIC ANALYSIS ACID RESISTANCE IN SHIGELLA SPECIES
    Pamela Small; Fiscal Year: 1992
    DESCRIPTION (Adapted from applicant's abstract): Shigella species, the causative agents of bacillary dysentery, are unique among enteric pathogens in the low infective dose required for disease...
  11. IPAC-MEDIATED INVASION OF EPITHELIAL CELLS BY SHIGELLA
    William Picking; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Shigella are gram negative enteric pathogens that cause bacillary dysentery, a serious world-wide health threat...
  12. Structure and Function of IpaC from Shigella flexneri
    William Picking; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Shigella flexneri is a gram-negative enteric pathogen that causes bacillary dysentery (shigellosis), which continues to be an important worldwide public health problem...
  13. The molecular mechanisms for the unipolar surface expression of IcsA of Shigella
    LAREAN DENISE BRANDON; Fiscal Year: 2010
    ..are obligate intracellular pathogens and causative agents of shigellosis (a form of bacillary dysentery) that causes an estimated 1.1 million deaths worldwide per annum...
  14. APOPTOSIS IN SHIGELLA INFECTIONS
    Claudio Basilico; Fiscal Year: 2004
    Shigellae are the etiological agents of bacillary dysentery, a severe form of diarrhea that is often fatal in infants. Shigellosis is an acute inflammatory disease...
  15. Intregration and Adaptation of HIV and Alcohol Risk Red*
    Linda Kaljee; Fiscal Year: 2006
    ..abstract_text> ..
  16. Molcular detection of weaponized arenaviruses
    Remi Charrel; Fiscal Year: 2003
    ..The ultimate goal is to propose a ready-to-use diagnostic kit for the detection and characterization of weaponized arenaviruses. ..
  17. Novel imaging biomarkers to address fundamental controversies in TB pathogenesis
    Sanjay Jain; Fiscal Year: 2009
    ....
  18. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2008
    ..abstract_text> ..
  19. Effectiveness of Selected NPIs in Reducing ILI among University Students
    TOMAS ARAGON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Gender Relations, Sexual Behaviors & Perceived HIV Risk
    Linda Kaljee; Fiscal Year: 2006
    ..abstract_text> ..
  21. Gastroenteritis and Extreme Weather Events in Elderly
    Elena Naumova; Fiscal Year: 2006
    ..abstract_text> ..
  22. Mathematical Modeling of Epidemic and Endemic Cholera
    David Hartley; Fiscal Year: 2007
    ..Such an understanding may also afford us insight into new prevention, intervention and control strategies to limit or prevent the occurrence of this potentially devastating disease. ..
  23. Shigella dysenteriae vaccine construction
    Eileen Barry; Fiscal Year: 2009
    ....
  24. Conserved pneumococcal protein live-vector vaccine
    Eileen Barry; Fiscal Year: 2007
    ..Typhi live vector strains, and provide preclinical data necessary for advancing promising candidates into clinical trials. ..
  25. BACTERIAL LIVE VECTOR-BASED VACCINE AGAINST MALARIA
    Myron Levine; Fiscal Year: 2004
    ..falciparum, and by these effects working in concert, we will ultimately be able to prevent disease completely in some subjects and to markedly ameliorate disease severity in others. ..