chlamydophila infections

Summary

Summary: Infections with bacteria of the genus CHLAMYDOPHILA.

Top Publications

  1. ncbi IFN-gamma induced persistent Chlamydia pneumoniae infection in HL and Mono Mac 6 cells: characterization by real-time quantitative PCR and culture
    Laura Mannonen
    Department of Virology, Haartman Institute, University of Helsinki, P O Box 21, 00014, Helsinki, Finland
    Microb Pathog 36:41-50. 2004
  2. ncbi Chronic infections and genetic factors in the development of ischemic stroke
    Zoltan Kis
    Department of Virology, National Center for Epidemiology, H 1097 Budapest, Gyali ut 2 6, Hungary
    New Microbiol 30:213-20. 2007
  3. ncbi Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis?
    Sebastian L Johnston
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London W2 1PG, UK
    Am J Respir Crit Care Med 172:1078-89. 2005
  4. ncbi Antigens of persistent Chlamydia pneumoniae within coronary atheroma from patients undergoing heart transplantation
    Nicole Borel
    Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    J Clin Pathol 65:171-7. 2012
  5. ncbi Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice
    C Scott Little
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    Neurobiol Aging 25:419-29. 2004
  6. pmc The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics, Infectious Diseases, and Immunology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Pathog 5:e1000379. 2009
  7. ncbi Chlamydia pneumoniae--an infectious risk factor for atherosclerosis?
    Lee Ann Campbell
    Department of Pathobiology, Box 357238, University of Washington, Seattle, Washington 98155, USA
    Nat Rev Microbiol 2:23-32. 2004
  8. pmc Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2
    Fei Cao
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Infect Immun 75:753-9. 2007
  9. pmc High prevalence of natural Chlamydophila species infection in calves
    JunBae Jee
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, 270 Greene Hall, Auburn, AL 36849 5519, USA
    J Clin Microbiol 42:5664-72. 2004
  10. ncbi Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Marek Smieja
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 107:251-7. 2003

Research Grants

  1. Chlamydia pneumoniae vaccine candidates
    Bernhard Kaltenboeck; Fiscal Year: 2004
  2. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
  3. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
  4. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
  5. CD8+T cell responses to Chlamydia pneumoniae
    Benjamin Wizel; Fiscal Year: 2006
  6. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
  7. Human Metapneumovirus in High Risk Populations
    Gregory Gray; Fiscal Year: 2005
  8. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
  9. Prenatal Malnutrition and the Aging Brain
    VICTORIA HERRERA; Fiscal Year: 2006
  10. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2004

Detail Information

Publications235 found, 100 shown here

  1. ncbi IFN-gamma induced persistent Chlamydia pneumoniae infection in HL and Mono Mac 6 cells: characterization by real-time quantitative PCR and culture
    Laura Mannonen
    Department of Virology, Haartman Institute, University of Helsinki, P O Box 21, 00014, Helsinki, Finland
    Microb Pathog 36:41-50. 2004
    ..pneumoniae EBs recovered decreased gradually after 3 days post inoculation, while C. pneumoniae genome load remained unaltered suggesting persistence of C. pneumoniae also in these cells...
  2. ncbi Chronic infections and genetic factors in the development of ischemic stroke
    Zoltan Kis
    Department of Virology, National Center for Epidemiology, H 1097 Budapest, Gyali ut 2 6, Hungary
    New Microbiol 30:213-20. 2007
    ..These results are consistent with the hypothesis that certain pathogens are involved in the development of ischemic stroke...
  3. ncbi Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis?
    Sebastian L Johnston
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London W2 1PG, UK
    Am J Respir Crit Care Med 172:1078-89. 2005
    ..The possible role of antibacterial therapy in the management of asthma and the need for well-designed studies to investigate this is also discussed...
  4. ncbi Antigens of persistent Chlamydia pneumoniae within coronary atheroma from patients undergoing heart transplantation
    Nicole Borel
    Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    J Clin Pathol 65:171-7. 2012
    ..Current theory suggests that C pneumoniae may persist at the site of infection via an alternative replicative form, known as an aberrant body...
  5. ncbi Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice
    C Scott Little
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    Neurobiol Aging 25:419-29. 2004
    ..pneumoniae may be a useful model for furthering our understanding of mechanisms, linked to infection, involved in the initiation of the pathogenesis of sporadic AD...
  6. pmc The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics, Infectious Diseases, and Immunology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Pathog 5:e1000379. 2009
    ..pneumoniae from the lungs and survival of the infectious challenge...
  7. ncbi Chlamydia pneumoniae--an infectious risk factor for atherosclerosis?
    Lee Ann Campbell
    Department of Pathobiology, Box 357238, University of Washington, Seattle, Washington 98155, USA
    Nat Rev Microbiol 2:23-32. 2004
    ..This review focuses on the accumulating evidence that chronic infection with Chlamydia pneumoniae, a ubiquitous human respiratory pathogen, might contribute to atherosclerotic lesion progression...
  8. pmc Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2
    Fei Cao
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Infect Immun 75:753-9. 2007
    ..pneumoniae, Pam, and E. coli LPS). Overall, our results suggest that activation of the LXR signaling pathway may affect potentially atherogenic processes modulated by the TLR ligands...
  9. pmc High prevalence of natural Chlamydophila species infection in calves
    JunBae Jee
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, 270 Greene Hall, Auburn, AL 36849 5519, USA
    J Clin Microbiol 42:5664-72. 2004
    ..02). Collectively, crowding strongly enhances the frequency and intensity of highly prevalent Chlamydophila infections in cattle.
  10. ncbi Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Marek Smieja
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 107:251-7. 2003
    ....
  11. ncbi Impact of latent infections with Chlamydophila species in young cattle
    Petra Reinhold
    Institute of Molecular Pathogenesis, Friedrich Loeffler Institute FLI, Naumburger Street 96 a, 07743 Jena, Germany
    Vet J 175:202-11. 2008
    ..In conclusion, naturally occurring infections with Chlamydophila species in calves were found to be associated with chronic effects on animal health at a subclinical level...
  12. ncbi Delivery of Chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in LDLr-/- mice
    A D Hauer
    Division of Biopharmaceutics, Leiden University, Leiden, The Netherlands
    Cardiovasc Res 69:280-8. 2006
    ..The role of Chlamydia pneumoniae in atherosclerosis is still debated. In this study a novel mouse model was applied to determine the direct impact of C. pneumoniae on the arterial wall and the development of atherosclerosis...
  13. ncbi Association of Chlamydia pneumoniae serology and ischemic stroke
    Zaki Noah Hasan
    Department of Neurology, Al Kindey College of Medicine, University of Baghdad, Jadiriya Baghdad, Iraq
    South Med J 104:319-21. 2011
    ..The aim of the study was to evaluate the association between Chlamydia pneumoniae infection and ischemic stroke...
  14. pmc Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice
    Hridayesh Prakash
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    J Biol Chem 285:20291-302. 2010
    ..These data demonstrated a role of XIAP for the integrity of both innate and cellular immune responses during C. pneumoniae infection...
  15. ncbi No evidence of involvement of Chlamydia pneumoniae in severe cerebrovascular atherosclerosis by means of quantitative real-time polymerase chain reaction
    Petra Apfalter
    Department of Clinical Microbiology, Institute of Hygiene and Medical Microbiology, University of Vienna, National Reference Laboratory for Chlamydia pneumoniae, Vienna University Hospital, Austria
    Stroke 35:2024-8. 2004
    ..The aim of this study was to analyze the prevalence of C. pneumoniae DNA in plaques of the carotid artery as well as in peripheral blood by means of a new, closed, real-time PCR system...
  16. ncbi Chlamydophila pneumoniae
    Almudena Burillo
    Clinical Microbiology Department, Hospital Universitario de Móstoles, C Río Júcar, S N, 28935 Móstoles, Madrid, Spain
    Infect Dis Clin North Am 24:61-71. 2010
    ..Meanwhile, adequate prospective studies have met with ethical and logistic barriers. Despite these limitations, North American guidelines recommend the antimicrobial treatment of patients with acute C pneumoniae respiratory infection...
  17. ncbi The atypical pneumonias: clinical diagnosis and importance
    B A Cunha
    Infectious Disease Division, Winthrop University Hospital, Mineola, New York 11501, USA
    Clin Microbiol Infect 12:12-24. 2006
    ..Because of the potential role of C. pneumoniae in coronary artery disease and multiple sclerosis (MS), and the role of M. pneumoniae and C. pneumoniae in causing or exacerbating asthma, atypical CAPs also have public health importance...
  18. ncbi Acute respiratory infection due to Chlamydia pneumoniae: current status of diagnostic methods
    Swati Kumar
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Clin Infect Dis 44:568-76. 2007
    ..Adoption of a more unified approach, both for choices of diagnostic methods and for validation of new molecular assays, is long overdue and will be critically important for development of a standardized test for clinical laboratories...
  19. ncbi Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60
    David L Hahn
    Department of Family Practice, Dean Medical Center, Madison, Wisconsin, USA
    Ann Allergy Asthma Immunol 101:614-8. 2008
    ..The pathogenesis of C trachomatis disease associations is thought to include molecular mimicry (autoimmunity), direct activation of the innate immune response via the CD14/toll-like receptor 4 complex, or both...
  20. pmc Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Milan, Italy
    Thorax 57:672-6. 2002
    ....
  21. ncbi Seropositivity to Chlamydia pneumoniae is associated with risk of first ischemic stroke
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 37:790-5. 2006
    ..The objective of this study is to determine whether serological evidence of C pneumoniae infection is associated with risk of ischemic stroke...
  22. ncbi Evidence for persistent Chlamydia pneumoniae infection of human coronary atheromas
    Nicole Borel
    Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, CH 8057 Zurich, Switzerland
    Atherosclerosis 199:154-61. 2008
    ..In the current study, we demonstrated the presence of aberrant bodies of C. pneumoniae in vivo in archival coronary atheromatous heart tissues by the immunogold electron microscopy technique...
  23. ncbi Heat shock proteins, inflammation, and cardiovascular disease
    A Graham Pockley
    Division of Clinical Sciences North, Clinical Sciences Centre, University of Sheffield, Northern General Hospital, Sheffield, UK
    Circulation 105:1012-7. 2002
  24. ncbi Standardizing Chlamydia pneumoniae assays: recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada)
    S F Dowell
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Clin Infect Dis 33:492-503. 2001
    ..These standards should be applied in future investigations and periodically modified as indicated...
  25. pmc cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection
    B K Coombes
    Department of Medical Sciences, McMaster University, and Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ontario, Canada L8N
    Infect Immun 69:1420-7. 2001
    ..In addition, the use of cDNA microarrays may prove useful for the study of host cell responses to C. pneumoniae infection during latent and replicative stages of infection and related pathology...
  26. ncbi Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation
    S Sasu
    Department of Medicine, New England Medical Center Hospitals and Tufts University School of Medicine, Boston Medical Center, Boston, Massachusetts, USA
    Circ Res 89:244-50. 2001
    ..Together these results indicate that C pneumoniae and chlamydial hsp60 are potent inducers of human VSMC proliferation and that these effects are mediated, at least in part, by rapid TLR4-mediated activation of p44/p42 MAPK...
  27. ncbi Evidence of an association between Chlamydia pneumoniae and cerebrovascular accidents
    G Bucurescu
    Neurology Service, Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Eur J Neurol 10:449-52. 2003
    ..The risk for stroke associated with Chlamydial circulating antibodies appeared to be independent of other risk factors such as diabetes and hypercholesterolemia...
  28. ncbi Chlamydia-related abortions in cattle from Graubunden, Switzerland
    N Borel
    Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, CH 8057 Zurich, Switzerland
    Vet Pathol 43:702-8. 2006
    ..The significance of chlamydia-like isolates other than Waddlia chondrophila remains an open question in abortion and needs further investigation...
  29. pmc Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study
    Soo Chan Carusone
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main St W, L8N 3Z5 Hamilton, Canada
    BMC Neurol 4:15. 2004
    ..pneumoniae may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of C. pneumoniae infection or inflammatory markers with vascular dementia...
  30. ncbi Prospective study of Chlamydia pneumoniae IgG and IgA seropositivity and risk of incident ischemic stroke
    David Tanne
    Stroke Unit, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel
    Cerebrovasc Dis 16:166-70. 2003
    ..Our aim was to evaluate prospectively the association between the presence of antibodies to C. pneumoniae (IgG and IgA) and the risk of incident ischemic stroke among patients with pre-existing vascular disease...
  31. ncbi Association of Chlamydia pneumoniae antibody with the cholesterol-lowering effect of statins
    Yasunori Sawayama
    Department of General Medicine, Kyushu University Hospital, Higashi ku, Fukuoka 812 8582, Japan
    Atherosclerosis 171:281-5. 2003
    ..These observations suggest that C. pneumoniae infection reduces the effect of lipid-lowering therapy on carotid atherosclerosis and that this organism may play a role in the progression of atherosclerosis...
  32. ncbi Carotid artery atherosclerotic plaque: clinical and morphological-immunohistochemical correlation
    Arunas Lastas
    Neurology and Neurosurgery Clinic of Vilnius University Emergency Hospital, Vilnius, Lithuania
    Med Sci Monit 10:CR606-14. 2004
    ..pneumoniae and complexity of the plaque...
  33. ncbi Detection of Chlamydia pneumoniae but not of Helicobacter pylori in symptomatic atherosclerotic carotids associated with enhanced serum antibodies, inflammation and apoptosis rate
    Daniel Neureiter
    Institute of Pathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, Germany
    Atherosclerosis 168:153-62. 2003
    ..Therefore, we evaluated the detection rate of C. pneumoniae and H. pylori in normal carotids vs. atherosclerotic carotids and compared these findings with serology, plaque morphology, inflammatory cell infiltrates and apoptosis rate...
  34. ncbi Chlamydia pneumoniae IgA seropositivity is associated with increased risk for atherosclerotic vascular disease, myocardial infarction and stroke in dialysis patients
    S C Wolf
    Medical Clinic III, University of Tubingen, Tubingen, Germany
    Clin Nephrol 59:273-9. 2003
    ....
  35. ncbi Chlamydia pneumoniae carriage and infection in hospitalized children with respiratory tract diseases
    S M Schmidt
    Dept of Infectious, Bronchopulmonary and Allergic Diseases, Children s and Youth Hospital, Soldmannstr 15, D 17487 Greifswald, Germany
    Infection 31:410-6. 2003
    ..The importance of Chlamydia pneumoniae respiratory tract infection in childhood is under discussion...
  36. ncbi Bovine Chlamydophila spp. infection: do we underestimate the impact on fertility?
    B Kaltenboeck
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, 270 Greene Hall, Auburn, AL 36849, USA
    Vet Res Commun 29:1-15. 2005
    ..Such infections proceed without apparent disease or with only subtle expressions of disease, but potentially have a large impact on bovine herd health and fertility...
  37. pmc Involvement of Chlamydia pneumoniae in atherosclerosis: more evidence for lack of evidence
    Margareta M Ieven
    Department of Medical Microbiology, University of Antwerp UA, B2610 Wilrijk, Belgium
    J Clin Microbiol 43:19-24. 2005
  38. ncbi Chlamydophila pneumoniae diagnostics: importance of methodology in relation to timing of sampling
    D Hvidsten
    Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
    Clin Microbiol Infect 15:42-9. 2009
    ..On the basis of these findings, a combination of nasopharyngeal swabbing for PCR detection and specific single-serum IgM measurement is recommended in cases of acute respiratory C. pneumoniae infection...
  39. ncbi Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study
    M Mosorin
    Department of Surgery, University of Oulu, Finland
    J Vasc Surg 34:606-10. 2001
    ..Because of the high prevalence of this disorder and its clinical, social, and economic relevance, a multicenter study should be performed to further investigate whether there is any place for medical treatment of small AAAs...
  40. ncbi Chlamydia pneumoniae and stroke: is there a direct relationship?
    Rubens J Gagliardi
    Faculty of Medical Sciences, Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil
    Arq Neuropsiquiatr 67:600-4. 2009
    ..To investigate the possible relationship between atherothrombotic stroke and Chlamydia pneumoniae...
  41. ncbi Role of Chlamydophila pneumoniae in children hospitalized for community-acquired pneumonia in Vienna, Austria
    Herbert Kurz
    Department of Pediatrics, Danube Hospital, Vienna, Austria
    Pediatr Pulmonol 44:873-6. 2009
    ..pneumoniae) as causative agent in youths and children hospitalized with community-acquired pneumonia (CAP). These data would serve as a rationale for empiric antimicrobial therapy...
  42. ncbi Relevance of the genetic polymorphism of NOD1 in Chlamydia pneumoniae seropositive stroke patients
    Z Tiszlavicz
    Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
    Eur J Neurol 16:1224-9. 2009
    ..NOD1 is a potent cytosolic receptor for C. pneumoniae. The aim of this study was to investigate the genetic polymorphism of NOD1 from the aspect of the development of stroke...
  43. ncbi The association between Chlamydia pneumoniae DNA in arherosclerotic plaque and major risk factors in patients undergoing coronary artery bypass grafting
    Daryoosh Kamal Hedayat
    Department of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Kardiol Pol 67:981-6. 2009
    ....
  44. ncbi Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk
    Tiina Huittinen
    National Public Health Institute, Oulu, Finland
    Arterioscler Thromb Vasc Biol 22:431-7. 2002
    ..2) when adjustment was made for age and smoking. In conclusion, an elevated human Hsp60 IgA antibody level was a risk factor for coronary events, especially when it was present together with C pneumoniae infection and inflammation...
  45. ncbi Is Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?
    Seyed Mohammad Alavi
    Infectious disease ward, Razi Hospital, Ahvaz Joundishapour University of Medical Sciences, Ahvaz, Iran
    J Infect Public Health 2:96-9. 2009
    ..Since these studies have reported controversial results, we performed this study to identify whether Cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction (ACI) in Iranian patients...
  46. ncbi The association of C (-260)-->T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients
    Tsun Mei Lin
    Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan
    Am J Clin Pathol 130:595-601. 2008
    ..3% vs 38.6%; P < .001). Our findings suggest that persistent C pneumoniae infection is independently associated with stroke in CC genotypes and the lowering of cHsp60 antibody levels in TT genotypes...
  47. ncbi The association of seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Am Coll Cardiol 40:1408-13. 2002
    ..We sought to determine whether seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus (CMV) is an independent predictor of incident cardiovascular disease...
  48. ncbi Chlamydophila pneumoniae
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Ospedale Maggiore, Milan, Italy
    Clin Microbiol Infect 15:29-35. 2009
    ..pneumoniae infection. New macrolides, ketolides and fluoroquinolones are other potentially effective drugs. This review analyses the most recent data concerning the involvement of C. pneumoniae in human diseases...
  49. ncbi The role of Chlamydia and Chlamydophila infections in reactive arthritis
    Antonietta Rizzo
    Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Faculty of Medicine and Surgery Second University of Naples, Italy
    Intern Med 51:113-7. 2012
    ....
  50. pmc Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization
    Nicolas W J Schröder
    Pediatric Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, CA, USA
    J Allergy Clin Immunol 122:595-602.e5. 2008
    ..A mechanistic reconciliation of these findings has not yet emerged. In particular, the role of innate immunity in this context is unclear...
  51. ncbi The relationship between seropositivity against Chlamydia pneumoniae and stroke and its subtypes in a Latvian population
    Viktorija Kēniņa
    Department of Neurology, Riga Stradins University, Riga, Latvia
    Medicina (Kaunas) 47:657-60. 2011
    ..The aim of this study was to determine whether serological evidence of infection with Chlamydia pneumoniae was associated with the risk of ischemic stroke and any of investigated stroke subtypes...
  52. ncbi Evaluation of different nucleic acid amplification techniques for the detection of M. pneumoniae, C. pneumoniae and Legionella spp. in respiratory specimens from patients with community-acquired pneumonia
    K Loens
    Department of Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp UIA, Antwerp, Belgium
    J Microbiol Methods 73:257-62. 2008
    ..It's practical attractiveness pleads for further optimalisation of the multiplex approach...
  53. ncbi Genome sequence of the cat pathogen, Chlamydophila felis
    Yoshinao Azuma
    Department of Microbiology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    DNA Res 13:15-23. 2006
    ..The genomic DNA sequence of C. felis provides information for comprehension of diseases and elucidation of the chlamydial evolution...
  54. ncbi Chronic and repeated Chlamydophila pneumoniae lung infection can result in increasing IL-4 gene expression and thickness of airway subepithelial basement membrane in mice
    Chiung Zuei Chen
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Formos Med Assoc 108:45-52. 2009
    ..This study evaluated immune responses in the lung and airway pathology of BALB/c mice with chronic and repeated C. pneumoniae infections...
  55. ncbi Chlamydophila (Chlamydia) pneumoniae induces histidine decarboxylase production in the mouse lung
    Katalin Burian
    Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
    Immunol Lett 89:229-36. 2003
    ..These results point to a strong association between local histamine production and other inflammatory mediators and are novel in demonstrating the role of histamine in the pathomechanism of C. pneumoniae infections...
  56. ncbi Chlamydia pneumoniae in elderly patients with stroke (C-PEPS): a case-control study on the seroprevalence of Chlamydia pneumoniae in elderly patients with acute cerebrovascular disease
    Joseph Ngeh
    Department of Medicine for Elderly People, Whipps Cross University Hospital, London, UK
    Cerebrovasc Dis 15:11-6. 2003
    ..We investigated whether serological markers of C. pneumoniae infection were associated with acute stroke or transient ischaemic attack (TIA), exclusively in elderly patients...
  57. ncbi Recent developments in the laboratory diagnosis of chlamydial infections
    Konrad Sachse
    Friedrich Loeffler Institut Federal Research Institute for Animal Health, Institute of Molecular Pathogenesis, Naumburger Str 96a, 07743 Jena, Germany
    Vet Microbiol 135:2-21. 2009
    ..Further, a combination of a specific real-time PCR assay and a microarray test for chlamydiae is proposed as an alternative reference standard to isolation by cell culture...
  58. ncbi Atypical pathogens and respiratory tract infections
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy
    Eur Respir J 24:171-81. 2004
    ....
  59. ncbi Diagnosis of ovine enzootic abortion using an indirect ELISA (rOMP91B iELISA) based on a recombinant protein fragment of the polymorphic outer membrane protein POMP91B of Chlamydophila abortus
    D Longbottom
    Moredun Research Institute, International Research Centre, Pentlands Science Park, Penicuik, Midlothian, UK
    FEMS Microbiol Lett 195:157-61. 2001
    ..5%) than the CFT. Furthermore, the iELISA was better at differentiating C. abortus- from C. pecorum-infected animals. The new rOMP91B iELISA test will prove a valuable tool for the routine serodiagnosis of C. abortus infection...
  60. pmc Replicate PCR testing and probit analysis for detection and quantitation of Chlamydia pneumoniae in clinical specimens
    M Smieja
    Hamilton Regional Laboratory Medicine Programme, McMaster University, Hamilton, Ontario, Canada
    J Clin Microbiol 39:1796-801. 2001
    ..Due to sampling variability, PCR tests done without replication may miss a large proportion of positive specimens, particularly for specimens with small amounts of target C. pneumoniae DNA present...
  61. ncbi Association between infection with Helicobacter pylori and Chlamydia pneumoniae and risk of ischemic stroke subtypes: Results from a population-based case-control study
    P U Heuschmann
    Unit for Stroke Research and Public Health Medicine, Department of Neurology, University of Erlangen, Germany
    Stroke 32:2253-8. 2001
    ..However, population-based data on chronic infection and stroke are lacking. Therefore, we investigated the association of both bacterial pathogens and ischemic stroke subtypes in a population-based case-control study...
  62. ncbi Chlamydia pneumoniae infections prevent the programmed cell death on THP-1 cell line
    C Romano Carratelli
    Dipartimento di Medicina Sperimentale, Sezione di Microbiologia e Microbiologia Clinica, Facolta di Medicina e Chirurgia, Seconda Universita degli Studi di Napoli, Via Santa Maria di Costantinopoli 16, 80138, Naples, Italy
    FEMS Microbiol Lett 215:69-74. 2002
    ..These data suggest that the anti-apoptotic effect of C. pneumoniae requires a heat-labile component released during infection, and that the effect is not lipopolysaccharide-dependent...
  63. ncbi High prevalence of chlamydial (Chlamydophila psittaci) infection in fetal membranes of aborted equine fetuses
    L Szeredi
    Central Veterinary Institute, Tábornok u 2, H 1149 Budapest, Hungary
    Vet Res Commun 29:37-49. 2005
    ..In conclusion, chlamydial infection of the genital tract should be considered a possible factor in equine reproductive disorders...
  64. ncbi Asthmatic persons are prone to the persistence of Chlamydia pneumoniae antibodies
    Mika Paldanius
    National Public Health Institute, Department of Child and Adolescent Health, P O Box 310, Aapistie 1, 90101 Oulu, Finland
    Diagn Microbiol Infect Dis 59:117-22. 2007
    ..Military recruits seem to be most vulnerable to C. pneumoniae infections during the period from January to June. The antibody titer changes were more rapid than previously thought...
  65. ncbi The intracellular life of chlamydiae
    Margaret R Hammerschlag
    Departments of Pediatrics and Medicine, Division of Pediatric Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Semin Pediatr Infect Dis 13:239-48. 2002
    ....
  66. pmc Antibody responses to recombinant protein fragments of the major outer membrane protein and polymorphic outer membrane protein POMP90 in Chlamydophila abortus-infected pregnant sheep
    Morag Livingstone
    Moredun Research Institute, International Research Centre, Pentlands Science Park, Penicuik EH26 0PZ, United Kingdom
    Clin Diagn Lab Immunol 12:770-7. 2005
    ..Earlier detection of infection will allow appropriate control measures to be taken to reduce environmental contamination, thus limiting the spread of infection, financial losses, and the possible risks of zoonotic transmission to humans...
  67. ncbi Chlamydia pneumoniae infection induces an unstable atherosclerotic plaque phenotype in LDL-receptor, ApoE double knockout mice
    R Ezzahiri
    Department of Vascular Surgery, University Hospital Maastricht, The Netherlands
    Eur J Vasc Endovasc Surg 26:88-95. 2003
    ..To study whether Chlamydia pneumoniae (Cpn) infection affects atherosclerotic plaque morphology in atherogenic (LDLr/ApoE(-/-)) mice...
  68. ncbi Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae
    Nuria Rodriguez
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
    Eur J Immunol 36:1145-55. 2006
    ..All TLR2(-/-) x TLR4(d/d) mice succumbed to the infection, while about 50% of TLR2(-/-) mice died. Taken together, the function of TLR2 and TLR4 is required to survive pulmonary infection with C. pneumoniae...
  69. ncbi Epidemiologic evaluation of multiple respiratory pathogens in cats in animal shelters
    Michael J Bannasch
    Maddie s Shelter Medicine Program, Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Feline Med Surg 7:109-19. 2005
    ..Antiherpetics and antimycoplasmal drugs may be beneficial for individual animal care. Results document the utility of comprehensive URI surveillance and herd management for specific pathogens typical in that shelter...
  70. pmc Development and evaluation of Chlamylege, a new commercial test allowing simultaneous detection and identification of Legionella, Chlamydophila pneumoniae, and Mycoplasma pneumoniae in clinical respiratory specimens by multiplex PCR
    C Ginevra
    Laboratoire de Bacteriologie virologie, GIMAP, Faculte de Medecine Jacques Lisfranc, Saint Etienne, France
    J Clin Microbiol 43:3247-54. 2005
    ..These overall results demonstrate that the Chlamylege assay is sensitive, specific, and convenient for the rapid detection and identification of atypical pathogens in clinical samples from patients with respiratory infections...
  71. ncbi Synergistic effect of persistent Chlamydia pneumoniae infection, autoimmunity, and inflammation on coronary risk
    Tiina Huittinen
    National Public Health Institute, Aapistie 1, PO Box 310, FIN 90101 Oulu, Finland
    Circulation 107:2566-70. 2003
    ....
  72. ncbi Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo
    Clarissa U Prazeres Da Costa
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
    Eur J Immunol 34:2874-84. 2004
    ..In conclusion, HSP60 from C. pneumoniae triggers inflammatory responses in vivo that differ from responses induced by endotoxin or CpG oligonucleotides and are dependent on TLR2 and 4...
  73. ncbi Prevalence of Chlamydophila felis and feline herpesvirus 1 in cats with conjunctivitis in northern Italy
    A Rampazzo
    College of Veterinary Medicine, University of Torino, 10095 Grugliasco, Italy
    J Vet Intern Med 17:799-807. 2003
    ..004), whereas the detection of FHV-1 did not significantly correlate with the clinical sign (P = .25), suggesting that, by itself. PCR is not suitable for the diagnosis of FHV-1-related conjunctivitis...
  74. ncbi Ovine enzootic abortion (OEA): antibody response in vaccinated sheep compared to naturally infected sheep
    N Borel
    I Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, CH 8057 Zurich, Switzerland
    Vet Res Commun 29:151-6. 2005
  75. pmc Quantitative detection of respiratory Chlamydia pneumoniae infection by real-time PCR
    Yvonne Kuoppa
    Department of Virology, University of Umea, Umea, Sweden
    J Clin Microbiol 40:2273-4. 2002
    ..Real-time PCR had efficiency equal to or better than that of nested touchdown PCR. This study confirmed sputum as the best sampling material to detect an ongoing C. pneumoniae infection...
  76. ncbi Novel PCR-EIA method for the detection of Chlamydia pneumoniae in respiratory specimens
    J Inman-Bamber
    Cooperative Research Centre for Diagnostics, Queensland University of Technology, Brisbane, Australia
    Mol Cell Probes 16:57-61. 2002
    ..This sensitive and robust PCR-EIA method can provide clinically relevant diagnostic evidence of current C. pneumoniae infection contributing to serious respiratory tract diseases such as COAD...
  77. ncbi Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis
    C Contini
    Section of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Mult Scler 14:564-6. 2008
    ..These findings suggest a possible association between C. pneumoniae and Chlamydia-like organism brain infections as a cofactor in MS development...
  78. ncbi Infectious agents and multiple sclerosis--are Chlamydia pneumoniae and human herpes virus 6 involved?
    Robert H Swanborg
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Gordon H Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA
    J Neuroimmunol 136:1-8. 2003
    ..pneumoniae or HHV-6 in MS. We therefore propose future studies that should clarify whether, and if so how, these and other organisms function in the pathogenesis of this disease...
  79. ncbi Chlamydia pneumoniae and acute aortic syndrome: a call for a multi-institutional study
    Eduardo Bossone
    Institute of Respiratory Disease, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena, Milano, Italy
    Monaldi Arch Chest Dis 70:68-70. 2008
    ..pneumoniae and acute aortic dissection. Well-designed large prospective studies are needed in order to clarify the pathophysiologic role of CP infection in acute and chronic aortic disease...
  80. pmc PCR in diagnosis of infection: detection of bacteria in cerebrospinal fluids
    Yoshimasa Yamamoto
    Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Clin Diagn Lab Immunol 9:508-14. 2002
  81. ncbi CD8+ T cells specific for a potential HLA-A*0201 epitope from Chlamydophila pneumoniae are present in the PBMCs from infected patients
    Jean Philippe Carralot
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Int Immunol 17:591-7. 2005
    ..Our studies pave the way to the immunomonitoring of the anti-Cpn CTL immune response present in patients suffering from different diseases potentially linked to Cpn or anti-Cpn immunity...
  82. ncbi Chlamydia pneumoniae and atherosclerosis
    J Thomas Grayston
    Clin Infect Dis 40:1131-2. 2005
  83. ncbi Association between seropositivity to Chlamydia pneumoniae and acute ischaemic stroke
    J Gil Madre
    Service of Internal Medicine, Hospital General La Mancha Centro, Alcazar de San Juan, Spain
    Eur J Neurol 9:303-6. 2002
    ..19% in control subjects (P < 0.001). In conclusion, we suggest an association between chronic infection by C. pneumoniae and acute ischaemic stroke...
  84. pmc Performance of three microimmunofluorescence assays for detection of Chlamydia pneumoniae immunoglobulin M, G, and A antibodies
    Mette Bennedsen
    Neisseria Unit, Statens Serum Institut, Copenhagen, Denmark
    Clin Diagn Lab Immunol 9:833-9. 2002
    ..The difference in endpoint titers of IgM antibodies is of no major concern, as the diagnosis of acute C. pneumoniae infection rests on the presence of IgM antibodies, not on their level...
  85. ncbi The effect of telithromycin in acute exacerbations of asthma
    Sebastian L Johnston
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, National Heart and Lung Institute, Imperial College London, United Kingdom
    N Engl J Med 354:1589-600. 2006
    ..We conducted a double-blind, randomized, placebo-controlled study to evaluate the efficacy of telithromycin in patients with acute exacerbations of asthma...
  86. pmc Chlamydia pneumoniae and COPD exacerbation
    T A R Seemungal
    Thorax 57:1087-8; author reply 1088-9. 2002
  87. pmc Measurement of Chlamydia pneumoniae-specific immunoglobulin A (IgA) antibodies by the microimmunofluorescence (MIF) method: comparison of seven fluorescein-labeled anti-human IgA conjugates in an in-house MIF test using one commercial MIF and one enzyme i
    Mika Paldanius
    National Public Health Institute Department of Medical Microbiology, University of Oulu, Oulu, Finland
    Clin Diagn Lab Immunol 10:8-12. 2003
    ..The titer agreement indicated by kappa coefficients was very good or good for all of the fluorescein-labeled conjugates and the EIA with low antibody titers but decreased with increasing titers...
  88. ncbi Chlamydia (Chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of Bax and apoptosis-inducing factor
    Johan Schöier
    Department of Molecular and Clinical Medicine, Division of Clinical Microbiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    FEMS Immunol Med Microbiol 47:207-16. 2006
    ..These results indicate that C. pneumoniae-induced apoptosis in human coronary artery endothelial cells is caspase-independent and regulated by Bax and apoptosis-inducing factor...
  89. ncbi Chlamydia pneumoniae and coronary artery disease: controversial results of serological studies
    Gulay Yetkin
    Int Immunopharmacol 6:1524-5. 2006
    ..pneumoniae by using both ELISA and MIF method. There are several factors which may underly the controversial results of seroepidemiological studies. I have commented on the report of Carratelli et al. regarding some of these factors...
  90. ncbi Identification and characterization of secreted effector proteins of Chlamydophila pneumoniae TW183
    Michael Herrmann
    Department of Gastroenterology RDR B3, ALTANA Pharma AG, Byk Gulden Strasse 2, 78467 Konstanz, Germany
    Res Microbiol 157:513-24. 2006
    ..Here we report the putatively type III-dependent secretion of CpMip into the inclusion membrane as well as the effect of its inhibition on C. pneumoniae infection of HEp-2 cells...
  91. ncbi Chlamydophila pneumonia: Specific mRNA in aorta ascendens in patients undergoing coronary artery by-pass grafting
    Christina Nyström-Rosander
    Department of Medical Sciences, Section of Infectious Diseases, Uppsala, Sweden christina nysrom r
    Scand J Infect Dis 38:758-63. 2006
    ..Our findings of viable and metabolically active bacteria in aortic tissue add further support to the hypothesis that Cp may have an active role in the pathogenesis of atherosclerosis...
  92. ncbi Chlamydia pneumoniae burden in carotid arteries is associated with upregulation of plaque interleukin-6 and elevated C-reactive protein in serum
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA, USA
    Arterioscler Thromb Vasc Biol 25:2648-53. 2005
    ....
  93. ncbi Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-alpha-dependent pathway
    Y S Cho
    Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Clin Exp Allergy 35:1625-31. 2005
    ....
  94. ncbi Disparate innate immune responses to persistent and acute Chlamydia pneumoniae infection in chronic obstructive pulmonary disease
    Daniel Droemann
    Medical Clinic, Research Center Borstel, Parkallee 35, D 23845 Borstel, Germany
    Am J Respir Crit Care Med 175:791-7. 2007
    ..Chlamydia pneumoniae (Cpn) infection may play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Few data are available comparing persistent and acute infection of this pathogen in the human respiratory tract...
  95. ncbi Evaluation of two commercial assays for the detection of Chlamydophila abortus antibodies
    E Vretou
    Department of Microbiology, Hellenic Pasteur Institute, 127 Avenue Vassilissis Sofias, 115 21 Athens, Greece
    Vet Microbiol 123:153-61. 2007
    ..The C. abortus ELISA by the Institut Pourquier identified less OEA-positive sera than the other assays though it identified correctly 9 of 10 OEA-positive flocks. The basis of the discordant results is discussed...
  96. ncbi A clinically silent respiratory infection with Chlamydophila spp. in calves is associated with airway obstruction and pulmonary inflammation
    Julia Jaeger
    Institute of Molecular Pathogenesis in the Friedrich Loeffler Institute Federal Research Institute for Animal Health, Naumburger Str 96a, 07743 Jena, Germany
    Vet Res 38:711-28. 2007
    ..Data obtained in this study provide new insight illustrating the impact of nearly ubiquitous subclinical infections on the respiratory system...
  97. ncbi Comparison of ELISA and CFT assays for Chlamydophila abortus antibodies in ovine sera
    L M E McCauley
    Primary Industries Research Victoria, Department of Primary Industries, Attwood, VIC 3049, Australia
    Aust Vet J 85:325-8. 2007
    ..To compare the sensitivity and specificity of Chlamydophila abortus antibody assays, to find a suitable serological assay for testing sheep for export...
  98. pmc Investigation of Chlamydophila spp. in dairy cows with reproductive disorders
    Ann Charlotte Godin
    Division of Ruminant Medicine and Veterinary Epidemiology, Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences SLU, SE 750 07, Uppsala, Sweden
    Acta Vet Scand 50:39. 2008
    ..Reports worldwide indicate high prevalence of Chlamydophila spp. infection in cattle. To assess the prevalence in Sweden, 525 cows in 70 dairy herds with reproductive disorders was investigated...
  99. ncbi OmpA and antigenic diversity of bovine Chlamydophila pecorum strains
    B Kaltenboeck
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Vet Microbiol 135:175-80. 2009
    ..pecorum OmpA proteins in a host species can occupy the entire evolutionary bandwidth within C. pecorum. The variant immunoblot reactivities support the notion of considerable genomic plasticity of C. pecorum...
  100. ncbi Coinfection of laboratory rats with Mycoplasma pulmonis and Chlamydia pneumoniae
    Sueli B Damy
    Medical School of University of São Paulo, Sao Paulo, Brazil
    Contemp Top Lab Anim Sci 42:52-6. 2003
    ....
  101. ncbi Phagocytes transmit Chlamydia pneumoniae from the lungs to the vasculature
    J Gieffers
    Institute for Medical Microbiology and Hygiene, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Eur Respir J 23:506-10. 2004
    ..This is the first description of granulocytes acting as a reservoir for Chlamydia pneumoniae early in infection...

Research Grants28

  1. Chlamydia pneumoniae vaccine candidates
    Bernhard Kaltenboeck; Fiscal Year: 2004
    ..pneumoniae vaccine candidate proteins in respiratory disease models using several inbred mouse strains. ..
  2. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  3. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  4. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  5. CD8+T cell responses to Chlamydia pneumoniae
    Benjamin Wizel; Fiscal Year: 2006
    ..pneumoniae and will suggest methods of immunological intervention in infections caused by C. pneumoniae and other chlamydial pathogens. ..
  6. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
  7. Human Metapneumovirus in High Risk Populations
    Gregory Gray; Fiscal Year: 2005
    ..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
  8. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
    ..Dub6) in the fields of HIV metabolic and renal complications, renal vascular and glomerular pathology, and clinical trials design and implementation. ..
  9. Prenatal Malnutrition and the Aging Brain
    VICTORIA HERRERA; Fiscal Year: 2006
    ..abstract_text> ..
  10. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2004
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  11. HYPERTENSION / ATHEROSCLEROSIS PARADIGMS
    VICTORIA HERRERA; Fiscal Year: 2002
    ..This research proposal will provide key information on mechanisms that underlie the acceleration of atherosclerosis by hypertension which will identify new strategies for intervention. ..
  12. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  13. Pathogenesis of Persistent Chlamydial STDs
    Deborah Dean; Fiscal Year: 2007
    ..1 Description, ..
  14. Innovative Investigations and Therapies for Asthma
    Richard Martin; Fiscal Year: 2007
    ..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..
  15. Risk of Blood Borne Transmission of CJD
    Shimian Zou; Fiscal Year: 2008
    ..Publishanddisseminateresultsof thestudy. ..
  16. Environmental Toxicants in Fetal Basis of Adult-onset Stroke
    VICTORIA HERRERA; Fiscal Year: 2007
    ..Currently, environmental subtoxicant-induced fetal programming is not factored in as confounder in genetic studies of susceptibility to complex multifactorial diseases. ..
  17. MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISM
    Maria Lopes Virella; Fiscal Year: 2001
    ..Our overall objective is to provide insight into the mechanisms by which anti-LDL antibodies and macrophage activation may contribute to the development(acceleration of the arteriosclerotic process. ..
  18. TRANSGENIC RAT MODELS OF ALZHEIMER'S DISEASE
    VICTORIA HERRERA; Fiscal Year: 2002
    ..abstract_text> ..
  19. Pilot Trial of Metformin in Amnestic MCI
    Jose A Luchsinger; Fiscal Year: 2010
    ....
  20. Effect of donor tissue gp96 on allograft immunity
    ALAN POCKLEY; Fiscal Year: 2003
    ..In particular, gp96 would present the alloantigenic fingerprint of the donor to the recipient immune system, and the requirement for tissue cross-matching may be rendered unnecessary. ..
  21. Vascular factors, amyloid beta, and Alzheimer's disease
    Jose Luchsinger; Fiscal Year: 2004
    ..abstract_text> ..
  22. ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONS
    Richard Martin; Fiscal Year: 2003
    ....
  23. The Effect of Mycoplasma on Chronic Asthma
    Richard Martin; Fiscal Year: 2008
    ..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..
  24. Innate Immunity and RSV Infection in Children
    Theresa Guilbert; Fiscal Year: 2007
    ..Accomplishment of these aims will allow us to begin to elucidate the immune mechanisms of the major gene-environment interactions influencing early childhood respiratory disease. ..
  25. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Richard Martin; Fiscal Year: 2002
    ....
  26. CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
    Alan Hudson; Fiscal Year: 2002
    ..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..
  27. Reiter's syndrome mechanism of chlamydial pathogenesis
    Alan Hudson; Fiscal Year: 2008
    ....
  28. Gene Expression in Acute and Chronic Neurologic Disease
    Donald Gilden; Fiscal Year: 2008
    ..This concerted effort is focused on prospective studies to delineate the cause, pathogenesis and eventual prevention of viral and demyelinating diseases of the human nervous system. ..