cat scratch disease

Summary

Summary: A self-limiting bacterial infection of the regional lymph nodes caused by AFIPIA felis, a gram-negative bacterium recently identified by the Centers for Disease Control and Prevention and by BARTONELLA HENSELAE. It usually arises one or more weeks following a feline scratch, with raised inflammatory nodules at the site of the scratch being the primary symptom.

Top Publications

  1. pmc Genomic variation of Bartonella henselae strains detected in lymph nodes of patients with cat scratch disease
    Zaher Zeaiter
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine, Marseille, France
    J Clin Microbiol 40:1023-30. 2002
  2. pmc Detection of Bartonella henselae DNA by two different PCR assays and determination of the genotypes of strains involved in histologically defined cat scratch disease
    A Sander
    Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Freiburg Germany
    J Clin Microbiol 37:993-7. 1999
  3. ncbi Cat-scratch disease: epidemiology, aetiology and treatment
    J J Windsor
    Aberystwyth Public Health Laboratory, Bronglais Hospital, Wales, UK
    Br J Biomed Sci 58:101-10. 2001
  4. ncbi The expanding spectrum of Bartonella infections: II. Cat-scratch disease
    J W Bass
    Department of Pediatrics, Tripler Army Medical Center, Honolulu, HI 96859 5000, USA
    Pediatr Infect Dis J 16:163-79. 1997
  5. pmc Diagnosis of cat scratch disease with detection of Bartonella henselae by PCR: a study of patients with lymph node enlargement
    Yves Hansmann
    Service des Maladies Infectieuses et Tropicales, Hopitaux Universitaires de Strasbourg, 1, Place de l Hopital, 67091 Strasbourg Cedex, France
    J Clin Microbiol 43:3800-6. 2005
  6. pmc Western immunoblotting for Bartonella endocarditis
    Pierre Houpikian
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine de Marseille, 13385 Marseille Cedex, France
    Clin Diagn Lab Immunol 10:95-102. 2003
  7. ncbi Cat scratch disease from a domestic dog
    Tun Chieh Chen
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Formos Med Assoc 106:S65-68. 2007
  8. pmc Seroprevalence of antibodies to Bartonella henselae in patients with cat scratch disease and in healthy controls: evaluation and comparison of two commercial serological tests
    A Sander
    Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Klinikum der Universität Freiburg, Germany
    Clin Diagn Lab Immunol 5:486-90. 1998
  9. ncbi The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens
    D A Relman
    Department of Microbiology and Immunology, Stanford University, Calif
    N Engl J Med 323:1573-80. 1990
  10. ncbi Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease
    M J Dolan
    Wilford Hall USAF Medical Center, Lackland AFB, Texas
    Ann Intern Med 118:331-6. 1993

Research Grants

  1. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
  2. BARTONELLA--A MODEL FOR AN AIDS OPPORTUNISTIC PATHOGEN
    Jane Koehler; Fiscal Year: 2002
  3. MOLECULAR CHARACTERIZATION OF ROCHALIMAEA ANTIGENS
    Burt Anderson; Fiscal Year: 1999
  4. Pediatric Transplant Infections and Outcomes
    Vikas Dharnidharka; Fiscal Year: 2006

Detail Information

Publications205 found, 100 shown here

  1. pmc Genomic variation of Bartonella henselae strains detected in lymph nodes of patients with cat scratch disease
    Zaher Zeaiter
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine, Marseille, France
    J Clin Microbiol 40:1023-30. 2002
    Bartonella henselae is the primary agent of cat scratch disease (CSD). In order to study the genetic variation of B...
  2. pmc Detection of Bartonella henselae DNA by two different PCR assays and determination of the genotypes of strains involved in histologically defined cat scratch disease
    A Sander
    Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Freiburg Germany
    J Clin Microbiol 37:993-7. 1999
    b>Cat scratch disease (CSD) is a common cause of subacute regional lymphadenopathy, not only in children but also in adults...
  3. ncbi Cat-scratch disease: epidemiology, aetiology and treatment
    J J Windsor
    Aberystwyth Public Health Laboratory, Bronglais Hospital, Wales, UK
    Br J Biomed Sci 58:101-10. 2001
    ..In complicated CSD, treatment with trimethoprim-sulphamethoxazole, ciprofloxacin or azithromycin is recommended, with gentamicin being reserved for the severely ill patient...
  4. ncbi The expanding spectrum of Bartonella infections: II. Cat-scratch disease
    J W Bass
    Department of Pediatrics, Tripler Army Medical Center, Honolulu, HI 96859 5000, USA
    Pediatr Infect Dis J 16:163-79. 1997
    ..In addition clarification of the epidemiology of B. elizabethae infections in humans may be helpful in understanding the nature of infection with Bartonella organisms...
  5. pmc Diagnosis of cat scratch disease with detection of Bartonella henselae by PCR: a study of patients with lymph node enlargement
    Yves Hansmann
    Service des Maladies Infectieuses et Tropicales, Hopitaux Universitaires de Strasbourg, 1, Place de l Hopital, 67091 Strasbourg Cedex, France
    J Clin Microbiol 43:3800-6. 2005
    b>Cat scratch disease (CSD) is mostly due to Bartonella henselae after inoculation of the organism through a skin injury...
  6. pmc Western immunoblotting for Bartonella endocarditis
    Pierre Houpikian
    Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine de Marseille, 13385 Marseille Cedex, France
    Clin Diagn Lab Immunol 10:95-102. 2003
    ..by molecular techniques), 11 patients with chronic Bartonella quintana bacteremia, and 10 patients with cat scratch disease. Patients with IE were Western blot positive in 49 of 51 cases, and significant cross-reactivity with three ..
  7. ncbi Cat scratch disease from a domestic dog
    Tun Chieh Chen
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Formos Med Assoc 106:S65-68. 2007
    b>Cat scratch disease (CSD), caused by Bartonella henselae, is a zoonosis and characterized by self-limited lymphadenopathy. It is transmitted commonly by scratch or bite from cats or kitten...
  8. pmc Seroprevalence of antibodies to Bartonella henselae in patients with cat scratch disease and in healthy controls: evaluation and comparison of two commercial serological tests
    A Sander
    Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Klinikum der Universität Freiburg, Germany
    Clin Diagn Lab Immunol 5:486-90. 1998
    ..henselae is a widely accepted diagnostic procedure for laboratory confirmation of the diagnosis of cat scratch disease (CSD). In this study a commercially available indirect immunofluorescence assay (IFA) based on B...
  9. ncbi The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens
    D A Relman
    Department of Microbiology and Immunology, Stanford University, Calif
    N Engl J Med 323:1573-80. 1990
    ..The agent is often visualized in tissue sections of lesions with Warthin-Starry staining, but the bacillus has not been successfully cultured or identified. This bacillus may also cause cat scratch disease.
  10. ncbi Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease
    M J Dolan
    Wilford Hall USAF Medical Center, Lackland AFB, Texas
    Ann Intern Med 118:331-6. 1993
    To describe a clinical syndrome of cat scratch disease caused by Rochalimaea henselae, including methods for isolation of the organism from tissue and for identification.
  11. ncbi Detection of antibodies to Bartonella henselae in clinically diagnosed cat scratch disease
    J P Flexman
    Department of Clinical Microbiology and Infectious Diseases, Royal Perth Hospital, WA
    Med J Aust 166:532-5. 1997
    To determine the usefulness of an indirect immunoflourescence antibody test for antibodies to Bartonella henselae in diagnosing cat scratch disease (CSD).
  12. ncbi Macular hole in cat scratch disease
    Thomas A Albini
    Baylor College of Medicine, Department of Ophthalmology, Houston, TX 77030, USA
    Am J Ophthalmol 140:149-51. 2005
    To report the development of a macular hole as a complication of cat scratch disease.
  13. ncbi Clinical implication of prolonged fever in children with cat scratch disease
    Kumiko Tsujino
    Department of Pathology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Infect Chemother 10:227-33. 2004
    b>Cat scratch disease, caused by Bartonella henselae, typically presents with a localized lymphadenopathy with a brief period of fever and general symptoms...
  14. ncbi Cat-scratch disease in elderly patients
    Ronen Ben-Ami
    Infectious Disease Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Infect Dis 41:969-74. 2005
    ..Cat-scratch disease (CSD) is mostly contracted by children and young adults. To our knowledge, CSD in elderly patients has never been characterized, and it may be underrecognized in this age group...
  15. ncbi Prevalence of serologic evidence of cat scratch disease in patients with neuroretinitis
    E B Suhler
    Casey Eye Institute, Department of Ophthalmology, Oregon Health Sciences University, Portland 97035, USA
    Ophthalmology 107:871-6. 2000
    ..To determine the prevalence of Bartonella henselae seropositivity in patients with a clinical diagnosis of neuroretinitis...
  16. ncbi Circulating cytokines in patients with cat scratch disease
    N G Papadopoulos
    Research Laboratories, Second Department of Pediatrics, School of Medicine, University of Athens, Athens, Greece
    Clin Infect Dis 33:e54-6. 2001
    ..IL-6, and IL-10, measured by enzyme-linked immunosorbent assay, were significantly higher in patients with cat scratch disease (CSD) than in healthy control subjects; no induction of IL-12 was observed, and levels of interferon-gamma ..
  17. ncbi Musculoskeletal manifestations of cat scratch disease
    Eran Maman
    Department of Pediatric Orthopaedics, Dana Children s Hospital
    Clin Infect Dis 45:1535-40. 2007
    Musculoskeletal manifestations (MMs) are considered to be rare in cat scratch disease (CSD) and are not well characterized. We aimed to study MMs of CSD.
  18. ncbi Cat scratch disease causing hepatic masses after liver transplant
    Kavitha R Thudi
    Gastroenterology and Hepatology Division, Department of Internal Medicine, Saint Louis University Hospital, St Louis, MO, USA
    Liver Int 27:145-8. 2007
    Hepatic cat scratch disease is rarely reported in liver transplant recipients and has never been reported with discrete liver lesions in the graft...
  19. ncbi Serological response to "Rochalimaea henselae" antigen in suspected cat-scratch disease
    R L Regnery
    Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333
    Lancet 339:1443-5. 1992
    ..These data suggest that the R henselae IFA test, or other serological assays based on R henselae, may be useful for diagnosis of CSD...
  20. ncbi [Hepatosplenic localization of cat scratch disease: two cases in immunocompetent adult patients]
    D Family-Pigné
    Service de Medecine Interne, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94000 Creteil, France
    Rev Med Interne 27:772-5. 2006
    ..However systemic clinical presentations are described in immunodeficient adults (bacillary angiomatosis, bacillary splenitis) and are less common in immunocompetent ones...
  21. ncbi Systemic cat scratch disease
    Hui Min Liao
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 105:674-9. 2006
    Systemic cat scratch disease (CSD) is often associated with prolonged fever and microabscesses in the liver and/or spleen. We report a case of systemic CSD with hepatic, splenic and renal involvement in an aboriginal child in Taiwan...
  22. ncbi Unsuspected extralymphocutaneous dissemination in febrile cat scratch disease
    A Fretzayas
    2nd Department of Pediatrics, P and A Kyriakou Children's Hospital, University of Athens, Greece
    Scand J Infect Dis 33:599-603. 2001
    b>Cat scratch disease (CSD) commonly manifests as regional self-limited lymphadenitis. However, dissemination of the infection to distant multiple sites may occur even in immunocompetent patients...
  23. ncbi Bartonella henselae infection mimicking a splenic lymphoma
    D Ghez
    Service des Maladies Infectieuses et Tropicales, , , Garches, France
    Scand J Infect Dis 33:935-6. 2001
    ..Splenic cat-scratch disease is an exceptional diagnosis in adults and can easily be mistaken for a splenic lymphoma, thereby leading to an unnecessary splenectomy...
  24. ncbi Isolated splenic cat scratch disease in an immunocompetent adult woman
    Jacob Gilad
    Department of Internal Medicine E, Soroka University Medical Center, and Faculty for Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Clin Infect Dis 36:e10-3. 2003
    We report a case of isolated splenic cat scratch disease in an immunocompetent woman. The clinical presentation of prolonged fever, night sweats, weakness, and intrasplenic lesions was highly suggestive of lymphoma...
  25. pmc Improved culture from lymph nodes of patients with cat scratch disease and genotypic characterization of Bartonella henselae isolates in Australia
    Pierre Edouard Fournier
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille, France
    J Clin Microbiol 40:3620-4. 2002
    ..1%) from Australian patients clinically suspected of having cat scratch disease by amplification of a fragment of the htrA gene. We isolated 17 B. henselae strains (20...
  26. pmc Study of genotypes and virB4 secretion gene of Bartonella henselae strains from patients with clinically defined cat scratch disease
    Sophie Woestyn
    Microbiology Unit, Faculty of Medicine, University of Louvain, B 1200 Brussels, Belgium
    J Clin Microbiol 42:1420-7. 2004
    Bartonella henselae is the causative agent of cat scratch disease (CSD), which usually presents as a self-limiting lymphadenopathy. Occasionally, the bacteria will spread and be responsible for tissue and visceral involvement. Two B...
  27. ncbi Beyond cat scratch disease: widening spectrum of Bartonella henselae infection
    Todd A Florin
    Division of General Pediatrics, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:e1413-25. 2008
    Bartonella henselae was discovered a quarter of a century ago as the causative agent of cat scratch disease, a clinical entity described in the literature for more than half a century...
  28. ncbi Cat scratch disease and other zoonotic Bartonella infections
    Bruno B Chomel
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 224:1270-9. 2004
  29. ncbi Isolated splenic cat scratch disease
    Louis Bernard
    Clin Infect Dis 37:860; author reply 860-1. 2003
  30. pmc From cat scratch disease to endocarditis, the possible natural history of Bartonella henselae infection
    Frédérique Gouriet
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, Marseille Cedex 05, France
    BMC Infect Dis 7:30. 2007
    ..To date, none of the reported patients have had a history of typical cat scratch disease (CSD) which is also a manifestation of infection with B. henselae.
  31. ncbi Cat scratch disease in Japan
    Masato Tsukahara
    Faculty of Health Sciences, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8554, Japan
    J Infect Chemother 8:321-5. 2002
  32. ncbi [Cat scratch disease with hepatosplenic involvement]
    D S Romero Ramírez
    An Pediatr (Barc) 61:450-1. 2004
  33. ncbi Epidemiology of cat-scratch disease hospitalizations among children in the United States
    Mary G Reynolds
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 24:700-4. 2005
    ..Infections can, however, be accompanied by focal or diffuse inflammatory responses (atypical CSD) involving neurologic, organ (liver/spleen), lymphatic or skeletal systems...
  34. ncbi Immunohistochemical study of lymph nodes in patients with cat scratch disease
    Ying You Lin
    Graduate Institute of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 105:911-7. 2006
    Bartonella henselaeis the causative agent of cat scratch disease (CSD), manifesting as fever and acute regional lymphadenopathy...
  35. pmc Detection of bartonella henselae DNA by polymerase chain reaction in a patient with cat scratch disease: a case report
    Ju Young Chung
    Department of Pediatrics, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Korea
    J Korean Med Sci 20:888-91. 2005
    We report a case of cat scratch disease caused by Bartonella henselae in Korea. A 25-yr-old woman developed left cervical lymphadenopathy with history of contact with a dog...
  36. ncbi Long-term serological analysis and clinical follow-up of patients with cat scratch disease
    Einat Metzkor-Cotter
    Bernard Pridan Laboratory for Molecular Biology of Infectious Diseases, Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Infect Dis 37:1149-54. 2003
    A highly specific enzyme immunoassay (EIA) was recently described for use in the diagnosis of cat scratch disease (CSD). However, data regarding EIA antibody kinetics or its correlation with long-term clinical follow-up data are lacking...
  37. ncbi PET scan-positive cat scratch disease in a patient with T cell lymphoblastic lymphoma
    Woondong Jeong
    Arlin Cancer Institute and New York Medical College, Valhalla, NY 10595, USA
    Leuk Res 29:591-4. 2005
    ..This was pathologically proven to be cat scratch disease. This case suggests that in the immunocompromised patients who had history of lymphoma, infectious etiology ..
  38. pmc Comparison of in-house and commercial slides for detection by immunofluorescence of immunoglobulins G and M against Bartonella henselae and Bartonella quintana
    M Maurin
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 9:1004-9. 2002
    ..henselae infections causing cat scratch disease (CSD), chronic bacteremia, or endocarditis...
  39. pmc Detection by immunofluorescence assay of Bartonella henselae in lymph nodes from patients with cat scratch disease
    J M Rolain
    Unite des Rickettsies, CNRS UMR 6020A, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 10:686-91. 2003
    ..At a cutoff titer of 64, the sensitivity of the IFA was 86.8% and the specificity was 74.1%. Diagnosis of cat scratch disease (CSD) may be improved, with a specificity of 100%, when the two tests (IFD and IFA) were negative; the ..
  40. ncbi Cat scratch disease: an unusual cause of facial palsy and partial ptosis: case report
    Kandasamy Ganesan
    Department of Oral and Maxillofacial Surgery, Leeds Dental Institute, Leeds Teaching Hospital NHS Trust, England
    J Oral Maxillofac Surg 63:869-72. 2005
  41. ncbi Co-infection with Esptein-Barr virus and Bartonella henselae resulting in systemic bartonellosis
    Liana Signorini
    Clinic of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy
    J Infect 45:206-7. 2002
  42. ncbi Cat scratch disease mimicking Richter's Syndrome in a patient with chronic lymphocytic leukemia
    Mohammad Razaq
    Department of Hematology, Coney Island Hospital, Brooklyn, NY 11235, USA
    Leuk Lymphoma 46:443-5. 2005
    ..Instead it showed findings consistent with cat scratch disease (CSD), later confirmed by serology...
  43. ncbi Cat scratch disease: analysis of 130 seropositive cases
    Kyoko Murakami
    Department of Pathology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8554, Japan
    J Infect Chemother 8:349-52. 2002
    To clarify the clinical manifestations of cat scratch disease (CSD), we evaluated a total of 130 seropositive patients with CSD. The patients' ages ranged from 1 to 68 years; 103 (79.2%) were under 18 years of age...
  44. pmc Limited diversity among human isolates of Bartonella henselae
    B Dillon
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, University of Sydney, New South Wales 2145, Australia
    J Clin Microbiol 40:4691-9. 2002
    ..They strengthen arguments for careful exploration of genotype-phenotype relationships and for the development of a multilocus enzyme electrophoresis and multilocus sequence typing-based approach to the phylogeny of B. henselae...
  45. ncbi Experimental infection of specific pathogen free (SPF) cats with two different strains of bartonella henselae type I: a comparative study
    Kazuhiro Yamamoto
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Res 33:669-84. 2002
    Domestic cats are the reservoir of Bartonella henselae, the main causative agent of cat scratch disease. We compared B. henselae type I infection characteristics in 6 SPF cats infected with a feline strain (4...
  46. pmc Genotypic characteristics of two serotypes of Bartonella henselae
    Bernard La Scola
    Unite des Rickettsies, CNRS UMR 6020, 13385 Marseille Cedex 5, France
    J Clin Microbiol 40:2002-8. 2002
    ..Study of 22 additional strains of B. henselae isolated from French bacteremic cats demonstrated that they all belong to one or the other of the proposed serotype or genotype...
  47. ncbi Transverse myelitis in 2 patients with Bartonella henselae infection (cat scratch disease)
    Peter Baylor
    Department of Medicine, Veteran s Affairs Medical Center, Fresno, CA 93703, USA
    Clin Infect Dis 45:e42-5. 2007
    b>Cat scratch disease is usually a benign, self-limiting condition. Neurological manifestations are uncommon and may consist of encephalopathy, seizures, and coma...
  48. ncbi Cat scratch disease in Connecticut. Epidemiology, risk factors, and evaluation of a new diagnostic test
    K M Zangwill
    Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333
    N Engl J Med 329:8-13. 1993
    Although cat scratch disease is commonly diagnosed in patients who have unexplained regional lymphadenopathy after encounters with cats, its epidemiology and the risk factors for disease are not clearly defined, and there is no generally ..
  49. ncbi [Atypical cat scratch disease in an immunocompetent school-aged child]
    M J Dorado Moles
    An Pediatr (Barc) 66:418-9. 2007
  50. ncbi DNA amplification for the diagnosis of cat-scratch disease in small-quantity clinical specimens
    B Avidor
    Laboratory for Molecular Biology of Infectious Diseases, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, 6 Weizman St, Tel-Aviv 64239, Israel
    Am J Clin Pathol 115:900-9. 2001
    ..Two of the 4 lymphadenitis samples and the 2 primary lesion specimens were PCR positive. The technique presented could facilitate CSD diagnosis from a wider range of clinical samples...
  51. pmc Lymphadenopathy in a novel mouse model of Bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta
    Stefanie Kunz
    Immunologie und Hygiene, Universitatsklinikum Erlangen, Wasserturmstrasse 3 5, Erlangen, Germany
    Am J Pathol 172:1005-18. 2008
    In immunocompetent humans, cat scratch disease (CSD) is elicited by the Gram-negative bacterium Bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understood...
  52. ncbi Chronic active myocarditis following acute Bartonella henselae infection (cat scratch disease)
    G R Meininger
    Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Am J Surg Pathol 25:1211-4. 2001
    ..of a healthy young man who developed chronic active myocarditis after infection with Bartonella henselae (cat scratch disease). He progressed to severe heart failure and underwent orthotopic heart transplantation...
  53. ncbi Enzyme immunoassay for the diagnosis of cat-scratch disease defined by polymerase chain reaction
    M Giladi
    Bernard Pridan Laboratory for Molecular Biology of Infectious Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Clin Infect Dis 33:1852-8. 2001
    ..Results of this study indicate that the EIA described herein can play an important role in the serodiagnosis of CSD, although improvement of the sensitivity, particularly that of the IgM, would be desirable...
  54. ncbi Emergence of distinct genetic variants in the population of primary Bartonella henselae isolates
    Mardjan Arvand
    Institut fur Medizinische Mikrobiologie, Virologie und Hygiene, Universitat Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Microbes Infect 8:1315-20. 2006
    ..Generation of genetic variants by B. henselae may represent an escape mechanism to circumvent the host specific immune responses...
  55. pmc Natural history of Bartonella infections (an exception to Koch's postulate)
    V Jacomo
    Unite des Rickettsies, CNRS, UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 9:8-18. 2002
  56. pmc Characterization of the natural population of Bartonella henselae by multilocus sequence typing
    J Iredell
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia
    J Clin Microbiol 41:5071-9. 2003
    ..henselae strains and suggesting that recombination has a role in shaping the genetic character of bartonellae...
  57. pmc Comparison of different DNA fingerprinting techniques for molecular typing of Bartonella henselae isolates
    A Sander
    Abteilung Mikrobiologie und Hygiene, Institut fur Medizinische Mikrobiologie und Hygiene, Klinikum der Universität Freiburg, Freiburg, Germany
    J Clin Microbiol 36:2973-81. 1998
    ..Our results suggest that the genetic heterogeneity of B. henselae strains is high. The methods applied were found useful for typing B. henselae isolates, providing tools for epidemiological and clinical follow-up studies...
  58. ncbi MR signal changes in a child with cat scratch disease encephalopathy and status epilepticus
    Kazumasa Ogura
    Department of Pediatrics, Faculty of Medicine, Obama Hospital, Fukui Medical University, Fukui 910 1193, Japan
    Eur Neurol 51:109-10. 2004
  59. ncbi Cat scratch disease with lymphadenitis, vertebral osteomyelitis, and spleen abscesses
    J M Rolain
    Unité des Rickettsies CNRS UMR A 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Ann N Y Acad Sci 990:397-403. 2003
    In this report we describe a 30-year old male patient with vertebral osteomyelitis and spleen abscesses with cat scratch disease. The diagnosis was made on the basis of molecular detection of Bartonella henselae either on lymph node ..
  60. ncbi Epilepsia partialis continua in cat scratch disease
    Monica Puligheddu
    Department of Cardiovascular and Neurological Sciences, University of Cagliari, SS 554, Bivio Sestu, 09042 Monserrato, Cagliari, Italy
    Seizure 13:191-5. 2004
    b>Cat scratch disease (CSD) is a world-wide, diffuse, non-epidemic infection caused by the Gram-negative bacillus Bartonella henselae...
  61. ncbi Feline bartonellosis and cat scratch disease
    Edward B Breitschwerdt
    College of Veterinary Medicine, North Carolina State University, Dipl ACVIM, 4700 Hillsborough Street, Raleigh, NC 27606, United States
    Vet Immunol Immunopathol 123:167-71. 2008
    ..As fleas are involved in the transmission among cats, the use of acaracide products to eliminate fleas from the environment is of critical importance to decrease the risk of B. henselae transmission among cats and to humans...
  62. ncbi The role of the host immune response in pathogenesis of Bartonella henselae
    Sandra Resto-Ruiz
    Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa 33612, USA
    DNA Cell Biol 22:431-40. 2003
    ..henselae has been proposed. Here, the current status of the role of the immune response in both controlling infection and in B. henselae-triggered immunopathogenesis is presented...
  63. pmc Persistent generalized lymphadenopathy and non-Hodgkin's lymphoma in AIDS: association with Rochalimaea henselae infection
    J B Peter
    Specialty Laboratories, Inc, Santa Monica, California 90404, USA
    Clin Diagn Lab Immunol 1:115-6. 1994
    b>Cat scratch disease, which is caused by infection with Rochalimaea henselae, is often manifested as lymphadenopathy. R. henselae has also been isolated from human immunodeficiency virus (HIV)-positive patients with bacillary angiomatosis...
  64. pmc Detection of Rochalimaea henselae DNA in specimens from cat scratch disease patients by PCR
    B Anderson
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
    J Clin Microbiol 32:942-8. 1994
    ..from 16 fresh (unfixed) lymph node biopsy specimens and nine aspirates from patients with clinical cat scratch disease (CSD) to assay for the presence of R. henselae or R. quintana DNA in these samples...
  65. pmc Acute clinical disease in cats following infection with a pathogenic strain of Bartonella henselae (LSU16)
    K L O'Reilly
    Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Infect Immun 67:3066-72. 1999
    Bartonella henselae is the causative agent of human cat scratch disease as well as several serious sequelae of infections, including bacillary angiomatosis and bacillary peliosis. Conflicting reports describe the pathogenesis of B...
  66. ncbi Diagnosis of cat scratch disease with Bartonella henselae infection in formalin-fixed paraffin-embedded tissues by two different PCR assays
    Xiang Qian
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Diagn Mol Pathol 14:146-51. 2005
    b>Cat scratch disease (CSD) is commonly caused by Bartonella henselae infection. Clinical history and histologic findings are often insufficient to establish a definitive diagnosis of CSD...
  67. ncbi Cat scratch disease due to Bartonella henselae infection mimicking parotid malignancy
    V A Kempf
    Institut fur Medizinische Mikrobiologie, Eberhard Karls Universitat, Tubingen, Germany
    Eur J Clin Microbiol Infect Dis 20:732-3. 2001
    ..The patient improved greatly upon antibiotic treatment and did not require surgery. Although uncommon, infection with Bartonella spp., particularly Bartonella henselae, should be included in the differential diagnosis of parotid tumors...
  68. ncbi Cat scratch disease and acute rejection after pediatric renal transplantation
    Vikas R Dharnidharka
    The Division of Pediatric Nephrology, Shands Children s Hospital and University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Pediatr Transplant 6:327-31. 2002
    b>Cat scratch disease (CSD) can lead to unexplained fever, generalized lymphadenopathy and organomegaly in immunocompetent individuals...
  69. pmc Isolation of Bartonella henselae DNA from the peripheral blood of a patient with cat scratch disease up to 4 months after the cat scratch injury
    Mardjan Arvand
    Institut fur Medizinische Mikrobiologie, Virologie, und Hygiene, Universitat Rostock, Schillingallee 70, 18057 Rostock, Germany
    J Clin Microbiol 44:2288-90. 2006
    We report the case of a girl with cervical lymphadenitis and a persistent primary lesion of cat scratch disease (CSD)...
  70. ncbi Isolated hepatic involvement of cat scratch disease in immunocompetent adults: Enhanced magnetic resonance imaging, pathological findings, and molecular analysis--two cases
    Giuseppina Marino Marsilia
    Department of Pathology, Cardarelli Hospital, Naples, Italy
    Int J Surg Pathol 14:349-54. 2006
    Visceral involvement in absence of lymphadenopathy is a rare manifestation in cat scratch disease; hepatic granulomas are rare, representing 0...
  71. ncbi [Cat scratch disease]
    M A Martín Díaz
    An Pediatr (Barc) 65:506-8. 2006
  72. pmc Adult systemic cat scratch disease associated with therapy for hepatitis C
    Zahida Bhatti
    Infectious Disease Division, VA Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, New York 14215, USA
    BMC Infect Dis 7:8. 2007
    We describe the first case of systemic cat scratch disease in a patient receiving peginterferon alpha-2a and ribavirin for treatment of hepatitis C...
  73. ncbi A report of cat scratch disease in Korea confirmed by PCR amplification of the 16S-23S rRNA intergenic region of Bartonella henselae
    Borum Suh
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    Korean J Lab Med 30:34-7. 2010
    We report a case of cat scratch disease in an 8-yr-old girl who presented with fever and enlargement of both axillary lymph nodes. Both aerobic and anaerobic cultures of the lymph node aspirate were negative for microbial growth...
  74. ncbi Analysis of data in 30 patients with cat scratch disease without lymphadenopathy
    Hidehiro Tsuneoka
    Faculty of Health Sciences, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Infect Chemother 12:224-6. 2006
    The prominent clinical manifestation of cat scratch disease is regional lymphadenopathy at the site of the cat scratch or bite, associated with fever or general symptoms...
  75. pmc Bartonella spp. as emerging human pathogens
    B E Anderson
    Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa 33612, USA
    Clin Microbiol Rev 10:203-19. 1997
    ..Since that time, Bartonella species have been associated with cat scratch disease, bacillary angiomatosis, and a variety of other disease syndromes...
  76. ncbi Confirmation of diagnosis of cat scratch disease by immunohistochemistry
    W Cheuk
    Am J Surg Pathol 30:274-5. 2006
  77. ncbi High prevalence of antibodies to Bartonella henselae among Italian children without evidence of cat scratch disease
    Francesco Massei
    Dipartimento di Medicina della Procreazione e dell Età Evolutiva, Universita di Pisa, Pisa, Italy
    Clin Infect Dis 38:145-8. 2004
    ..henselae infection. We found that B. henselae infection is common among children in central Italy, occurs early in life, is in most cases asymptomatic, and resolves spontaneously...
  78. ncbi Low prevalence of Bartonella henselae infections in Norwegian domestic and feral cats
    K Bergh
    Department of Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    APMIS 110:309-14. 2002
    Bartonella henselae is the causative agent of cat scratch disease (CSD). This clinical entity is very rarely encountered in human medical practice in Norway. B...
  79. ncbi [Two patients with Bartonella henselae infection from a dog]
    I Murano
    Department of Pediatrics, Yamaguchi Prefectural Central Hospital
    Kansenshogaku Zasshi 75:808-11. 2001
    ..Careful review of suspected CSD victims' history of contact with animals is important in making a prompt diagnosis of B. henselae infection...
  80. ncbi Rapid polymerase chain reaction-based confirmation of cat scratch disease and Bartonella henselae infection
    Ben Margolis
    Department of Pathology, Loyola University Medical Center, Maywood, Ill 60153, USA
    Arch Pathol Lab Med 127:706-10. 2003
    b>Cat scratch disease (CSD) commonly occurs secondary to Bartonella henselae infection, and the diagnosis has traditionally been made by microscopic findings, the identification of organisms by cytochemistry, and clinical history...
  81. ncbi Serodiagnosis of cat scratch disease: response to Bartonella henselae in children and a review of diagnostic methods
    A Sander
    Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    Eur J Clin Microbiol Infect Dis 20:392-401. 2001
    In this study, sera from 116 children without clinical evidence of cat scratch disease (CSD) and sera from 19 children with CSD were investigated by two different immunofluorescent assays (test A and test B) to evaluate the ..
  82. ncbi Bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues
    Roberto Manfredi
    Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
    Braz J Infect Dis 10:411-5. 2006
    ....
  83. ncbi [Endocarditis due to Bartonella spp. Three new clinical cases and Spanish literature review]
    Jose Antonio Oteo
    Area de Enfermedades Infecciosas, Complejo Hospitalario San Millán San Pedro de La Rioja, Hospital de La Rioja, Logrono, Espana
    Enferm Infecc Microbiol Clin 24:297-301. 2006
    ..Infections by Bartonella spp. include a wide spectrum of emerging and re-emerging infectious diseases, such as culture-negative endocarditis...
  84. ncbi An unusual outcome in a child with hepatosplenic cat-scratch disease
    Dalibor Vukelic
    University Hospital for Infectious Diseases Dr Fran Mihaljevic, Zagreb, Croatia
    Wien Klin Wochenschr 118:615-8. 2006
    ..henselae in immunocompetent children. We report a case of a 6-year-old boy with the hepatosplenic form of cat-scratch disease. Despite early diagnosis and long-term antimicrobial treatment, splenectomy could not be avoided...
  85. ncbi [Unusual manifestations of Bartonella infections]
    I Tokodi
    , ,
    Orv Hetil 142:2197-200. 2001
    The authors review the cases of two patients with an atypical form of cat scratch disease. The first case exhibited ileocoecal and hepatoportal lymphadenitis, and the second case the emerging symptoms of a non-specific granulomatous ..
  86. ncbi Cat-scratch disease in veterinary-associated populations and in its cat reservoir in Taiwan
    Chao Chin Chang
    Graduate Institute of Veterinary Public Health, School of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan
    Vet Res 37:565-77. 2006
    ..Our study further suggested that using only direct PCR of 16S-23S rRNA intergenic region or the combination of the PCR method and indirect immuno-fluorescence test will be useful to diagnose Bartonella-free cats...
  87. ncbi Antimicrobial susceptibility of Bartonella henselae using Etest methodology
    S Pendle
    Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, NSW, Australia
    J Antimicrob Chemother 57:761-3. 2006
    ..Previous descriptions of antimicrobial susceptibility have been largely limited to feline isolates and/or laboratory reference strains, with no accounting for genotypic or phenotypic diversity...
  88. ncbi [Determination of antibody titer to Bartonella henselae by indirect fluorescence antibody assay using B. henselae from domestic cats as antigen]
    Hidehiro Tsuneoka
    Department of Clinical Laboratory, Yamaguchi Kouseiren Nagato Hospital
    Kansenshogaku Zasshi 79:826-8. 2005
  89. ncbi Images in emergency medicine. Parinaud's oculoglandular syndrome
    Kari A Lemme
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Ann Emerg Med 46:406, 423. 2005
  90. pmc Cat scratch disease
    Alexander Williams
    St Thomas Health Centre, Exeter EX4 1HJ
    BMJ 324:1199-200. 2002
  91. ncbi [Diagnostic tests: Cat-scratch disease]
    Soichi Maruyama
    Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
    Nihon Rinsho 63:237-40. 2005
  92. ncbi [Bartonella infection]
    E Miftode
    Facultatea de Medicină, ,
    Rev Med Chir Soc Med Nat Iasi 105:486-9. 2001
    ....
  93. ncbi The expanded spectrum of bartonellosis in children
    Francesco Massei
    Department of Procreative Medicine and Child Development, Division of Pediatrics, University of Pisa Hospital, Italy
    Infect Dis Clin North Am 19:691-711. 2005
    ..A careful clinical history researching an intimate contact with a kitten associated with a specific serology and an abdominal ultrasound for typical hepatosplenic involvement may follow a rapid and accurate diagnosis...
  94. ncbi Disseminated Bartonella infection following liver transplantation
    Hugo Bonatti
    Transplant Center, Mayo Clinic, Jacksonville, FL, USA
    Transpl Int 19:683-7. 2006
    Bartonella henselae has not only been identified as the causative agent of cat scratch disease, but it is also associated with other significant infectious syndromes in the immunocompromised population. We describe two cases of B...
  95. ncbi [Bartonella henselae and its infections]
    Bekir Celebi
    Refik Saydam Hıfzıssıhha Merkezi Başkanlığı, Salgin Hastaliklar Araştirma Müdürlügü, Bakteriyel Zoonozlar Araştirma Laboratuvari, Ankara
    Mikrobiyol Bul 42:163-75. 2008
    ..feline reservoir host and is the most important zoonotic species as the cause of human diseases including cat scratch disease, bacillary angiomatosis, bacillary peliosis, bacteraemia, endocarditis and neurological disorders...
  96. ncbi Familial occurrence of cat-scratch disease, with varying clinical expression
    Alice Tung Wan Song
    Division of Infectious Diseases, Clinicas Hospital of the University of Sao Paulo, Sao Paulo, Brazil
    Scand J Infect Dis 39:728-30. 2007
    ..We present a report of B. henselae infection transmitted by the same kitten to 4 different individuals, each with different clinical characteristics, treatment, and evolution...
  97. pmc Characterization of an immunogenic outer membrane autotransporter protein, Arp, of Bartonella henselae
    Christine M Litwin
    Section of Clinical Immunology, Microbiology and Virology, Department of Pathology, 50 N Medical Drive, University of Utah, Salt Lake City, UT 84132, USA
    Infect Immun 75:5255-63. 2007
    Bartonella henselae is a recently recognized pathogenic bacterium associated with cat scratch disease, bacillary angiomatosis, and bacillary peliosis...
  98. ncbi Recurrent expressive aphasia as a presentation of cat-scratch encephalopathy
    James W Fox
    Children s Hospital of Akron, Division of Emergency Medicine, One Perkins Square, Akron, OH 44308, USA
    Pediatrics 119:e760-3. 2007
    ..Cat-scratch encephalopathy must be considered in the differential diagnoses when pediatric patients present with unusual neurologic symptoms...
  99. doi Hepatosplenic cat-scratch fever
    Federico R Laham
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine and Texas Children s Hospital, Houston, TX, USA
    Lancet Infect Dis 8:140. 2008
  100. ncbi [Serous macular detachment as an atypical sign in cat scratch disease]
    V M Asensio-Sánchez
    Hospital General, Medina del Campo, Valladolid, Espana
    Arch Soc Esp Oftalmol 81:717-9. 2006
    ..1 visual acuity in the left eye associated with a serous retinal detachment of the macula as the only ocular manifestation of cat scratch disease. This diagnosis was made by serum antibody titers and the clinical course.
  101. ncbi [Cat-scratch disease. Review of eight adult patients hospitalized for fever or adenopathy]
    Gonzalo Eymin
    Departamento de Medicina Interna, Hospital Clinico, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 134:1243-8. 2006
    ..Cat-scratch disease is common among children. Among adults the disease is less often considered in the differential diagnosis of enlarged lymph nodes and fever...

Research Grants4

  1. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..abstract_text> ..
  2. BARTONELLA--A MODEL FOR AN AIDS OPPORTUNISTIC PATHOGEN
    Jane Koehler; Fiscal Year: 2002
    ..fatal infections such as bacillary angiomatosis, peliosis hepatitis, relapsing bacteremia, endocarditis, cat scratch disease, neuroretinitis and encephalopathy...
  3. MOLECULAR CHARACTERIZATION OF ROCHALIMAEA ANTIGENS
    Burt Anderson; Fiscal Year: 1999
    ....
  4. Pediatric Transplant Infections and Outcomes
    Vikas Dharnidharka; Fiscal Year: 2006
    ..abstract_text> ..