tuberculosis

Summary

Summary: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.

Top Publications

  1. pmc Trends in tuberculosis incidence and their determinants in 134 countries
    C Dye
    Stop TB Department, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 87:683-91. 2009
  2. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
  3. ncbi Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    S T Cole
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
    Nature 393:537-44. 1998
  4. pmc An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Matthew P R Berry
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 466:973-7. 2010
  5. pmc Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
    Michele D Tameris
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Lancet 381:1021-8. 2013
  6. ncbi Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
  7. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
  8. ncbi The growing burden of tuberculosis: global trends and interactions with the HIV epidemic
    Elizabeth L Corbett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, England, UK
    Arch Intern Med 163:1009-21. 2003
  9. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
  10. doi Neutrophils in tuberculosis: friend or foe?
    David M Lowe
    Department of Medicine, Imperial College London, W2 1PG, UK
    Trends Immunol 33:14-25. 2012

Research Grants

  1. M. tuberculosis survival in Macrophages
    Richard Friedman; Fiscal Year: 2003
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
  3. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
  4. Rinn Song; Fiscal Year: 2016
  5. Roy Curtiss Iii; Fiscal Year: 2016
  6. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
  7. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
  8. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
  9. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
  10. Hardy Kornfeld; Fiscal Year: 2016

Detail Information

Publications410 found, 100 shown here

  1. pmc Trends in tuberculosis incidence and their determinants in 134 countries
    C Dye
    Stop TB Department, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 87:683-91. 2009
    To determine whether differences in national trends in tuberculosis incidence are attributable to the variable success of control programmes or to biological, social and economic factors.
  2. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
    Global control of tuberculosis is hampered by slow, insensitive diagnostic methods, particularly for the detection of drug-resistant forms and in patients with human immunodeficiency virus infection...
  3. ncbi Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    S T Cole
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
    Nature 393:537-44. 1998
    Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus...
  4. pmc An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Matthew P R Berry
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 466:973-7. 2010
    b>Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment...
  5. pmc Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
    Michele D Tameris
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Lancet 381:1021-8. 2013
    BCG vaccination provides incomplete protection against tuberculosis in infants. A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was designed to enhance the protective efficacy of BCG...
  6. ncbi Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to ..
  7. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..in combination with spoligotyping as the basis for large-scale, high-throughput genotyping of Mycobacterium tuberculosis. However, even the combination of these two methods is still less discriminatory than IS6110 fingerprinting...
  8. ncbi The growing burden of tuberculosis: global trends and interactions with the HIV epidemic
    Elizabeth L Corbett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, England, UK
    Arch Intern Med 163:1009-21. 2003
    The increasing global burden of tuberculosis (TB) is linked to human immunodeficiency virus (HIV) infection.
  9. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
    Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations...
  10. doi Neutrophils in tuberculosis: friend or foe?
    David M Lowe
    Department of Medicine, Imperial College London, W2 1PG, UK
    Trends Immunol 33:14-25. 2012
    ..These activities may have clinical importance in terms of new treatments, targeted interventions and vaccine strategies...
  11. pmc Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
    Iñaki Comas
    1 Genomics and Health Unit, Centre for Public Health Research CSISP FISABIO, Valencia, Spain 2 CIBER Centros de Investigación Biomédica en Red in Epidemiology and Public Health, Barcelona, Spain
    Nat Genet 45:1176-82. 2013
    b>Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries...
  12. pmc Disseminated tuberculosis in interferon gamma gene-disrupted mice
    A M Cooper
    Department of Microbiology, Colorado State University, Fort Collins 80523
    J Exp Med 178:2243-7. 1993
    The expression of protective immunity to Mycobacterium tuberculosis in mice is mediated by T lymphocytes that secrete cytokines...
  13. pmc An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
    J L Flynn
    Howard Hughes Medical Institute, Department of Microbiology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Exp Med 178:2249-54. 1993
    b>Tuberculosis, a major health problem in developing countries, has reemerged in recent years in many industrialized countries...
  14. pmc Vaccines against tuberculosis: where are we and where do we need to go?
    Tom H M Ottenhoff
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Pathog 8:e1002607. 2012
    ..review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB)...
  15. pmc Timing of initiation of antiretroviral drugs during tuberculosis therapy
    Salim S Abdool Karim
    Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa
    N Engl J Med 362:697-706. 2010
    The rates of death are high among patients with coinfection with tuberculosis and the human immunodeficiency virus (HIV)...
  16. pmc Mycobacterium tuberculosis: success through dormancy
    Martin Gengenbacher
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    FEMS Microbiol Rev 36:514-32. 2012
    b>Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around this globe, annually. The only vaccine, developed almost a century ago, provides limited protection only during childhood...
  17. doi The immunological life cycle of tuberculosis
    Joel D Ernst
    Department of Medicine, New York University School of Medicine, 522 First Avenue, Smilow 901, New York, New York 10016, USA
    Nat Rev Immunol 12:581-91. 2012
    Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M...
  18. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
    ..Excess TNF-alpha in association with tuberculosis may cause weight loss and night sweats, yet in animal models it has a protective role in the host response to ..
  19. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma response by CD4(+) T cells in the lung during subsequent M. tuberculosis infection...
  20. pmc Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology
    Danica Helb
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry, New Jersey, Newark, New Jersey 07103, USA
    J Clin Microbiol 48:229-37. 2010
    Current nucleic acid amplification methods to detect Mycobacterium tuberculosis are complex, labor-intensive, and technically challenging...
  21. pmc Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update
    Madhukar Pai
    McGill University and Montreal Chest Institute, Montreal, Quebec, Canada
    Ann Intern Med 149:177-84. 2008
    ..A recent meta-analysis showed that IGRAs have high specificity, even among populations that have received bacille Calmette-Guérin (BCG) vaccination. Sensitivity was suboptimal for TST and IGRAs...
  22. ncbi Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Immunity 2:561-72. 1995
    Understanding the immunological mechanisms of protection and pathogenesis in tuberculosis remains problematic...
  23. doi The challenge of new drug discovery for tuberculosis
    Anil Koul
    Department of Antimicrobial Research, Janssen Research and Development, Johnson and Johnson, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Nature 469:483-90. 2011
    b>Tuberculosis (TB) is more prevalent in the world today than at any other time in human history...
  24. doi Whole-genome sequencing and social-network analysis of a tuberculosis outbreak
    Jennifer L Gardy
    British Columbia Centre for Disease Control, Vancouver, BC, Canada
    N Engl J Med 364:730-9. 2011
    An outbreak of tuberculosis occurred over a 3-year period in a medium-size community in British Columbia, Canada...
  25. doi Immunological biomarkers of tuberculosis
    Gerhard Walzl
    Immunology Research Group, NRF DST Centre of Excellence for TB Biomedical Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa
    Nat Rev Immunol 11:343-54. 2011
    Currently there are no sufficiently validated biomarkers to aid the evaluation of new tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the development of more effective and shorter treatment regimens...
  26. pmc Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis
    Francois Xavier Blanc
    Pneumology Unit, Internal Medicine Department, Bicetre Hospital, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, France
    N Engl J Med 365:1471-81. 2011
    b>Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV)...
  27. pmc Timing of antiretroviral therapy for HIV-1 infection and tuberculosis
    Diane V Havlir
    University of California, San Francisco, 995 Potrero Ave, Bldg 80, Ward 84, San Francisco, CA 94110 2897, USA
    N Engl J Med 365:1482-91. 2011
    Antiretroviral therapy (ART) is indicated during tuberculosis treatment in patients infected with human immunodeficiency virus type 1 (HIV-1), but the timing for the initiation of ART when tuberculosis is diagnosed in patients with ..
  28. pmc A new evolutionary scenario for the Mycobacterium tuberculosis complex
    R Brosch
    Unite de Genetique Moleculaire Bacterienne, Laboratoire de Génomique des Microorganismes Pathogènes, and Centre National de Référence des Mycobactéries, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 99:3684-9. 2002
    ..events in the genomes of the tubercle bacilli has been evaluated in a total of 100 strains of Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium canettii, Mycobacterium microti, and Mycobacterium bovis...
  29. pmc Patient adherence to tuberculosis treatment: a systematic review of qualitative research
    Salla A Munro
    South African Cochrane Centre, Medical Research Council of South Africa, Cape Town, South Africa
    PLoS Med 4:e238. 2007
    b>Tuberculosis (TB) is a major contributor to the global burden of disease and has received considerable attention in recent years, particularly in low- and middle-income countries where it is closely associated with HIV/AIDS...
  30. pmc Cell-mediated immune responses in tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Annu Rev Immunol 27:393-422. 2009
    b>Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends on productive infection of this critical organ...
  31. pmc Integration of antiretroviral therapy with tuberculosis treatment
    Salim S Abdool Karim
    Centre for the AIDS Programme of Research in South Africa, Durban, South Africa
    N Engl J Med 365:1492-501. 2011
    We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis treatment remains unresolved.
  32. doi Revisiting the role of the granuloma in tuberculosis
    Lalita Ramakrishnan
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Immunol 12:352-66. 2012
    The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of tuberculosis. It is historically regarded as a host-protective structure that 'walls off' the infecting mycobacteria...
  33. pmc Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes
    Aditya Venugopal
    Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Cell Host Microbe 9:21-31. 2011
    Mycobacterium tuberculosis (Mtb) adapts to persist in a nutritionally limited macrophage compartment...
  34. doi Scaling up interventions to achieve global tuberculosis control: progress and new developments
    Mario Raviglione
    Stop TB Department, WHO, Geneva, Switzerland
    Lancet 379:1902-13. 2012
    b>Tuberculosis is still one of the most important causes of death worldwide. The 2010 Lancet tuberculosis series provided a comprehensive overview of global control efforts and challenges. In this update we review recent progress...
  35. ncbi Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection - United States, 2010
    Gerald H Mazurek
    Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-25. 2010
    ..Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR;54[No. RR-15]:49-55)...
  36. ncbi HIV infection and multidrug-resistant tuberculosis: the perfect storm
    Charles D Wells
    Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S86-107. 2007
    Multidrug-resistant (MDR) tuberculosis (TB) has emerged as a global epidemic, with ~425,000 new cases estimated to occur annually...
  37. doi Drivers of tuberculosis epidemics: the role of risk factors and social determinants
    Knut Lonnroth
    World Health Organization, Geneva, Switzerland
    Soc Sci Med 68:2240-6. 2009
    The main thrust of the World Health Organization's global tuberculosis (TB) control strategy is to ensure effective and equitable delivery of quality assured diagnosis and treatment of TB...
  38. doi The population dynamics and control of tuberculosis
    Christopher Dye
    World Health Organization, CH1211 Geneva 27, Switzerland
    Science 328:856-61. 2010
    More than 36 million patients have been successfully treated via the World Health Organization's strategy for tuberculosis (TB) control since 1995...
  39. pmc Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies
    Christie Y Jeon
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 5:e152. 2008
    Several studies have suggested that diabetes mellitus (DM) increases the risk of active tuberculosis (TB). The rising prevalence of DM in TB-endemic areas may adversely affect TB control...
  40. pmc Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
    Luis B Barreiro
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:1204-9. 2012
    b>Tuberculosis (TB) is a major public health problem...
  41. doi SITVITWEB--a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology
    Christophe Demay
    WHO Supranational TB Reference Laboratory, Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Abymes Cedex, Guadeloupe
    Infect Genet Evol 12:755-66. 2012
    Among various genotyping methods to study Mycobacterium tuberculosis complex (MTC) genotypic polymorphism, spoligotyping and mycobacterial interspersed repetitive units-variable number of DNA tandem repeats (MIRU-VNTRs) have recently ..
  42. pmc Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β
    Bibhuti B Mishra
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 14:52-60. 2013
    ..During chronic infections such as tuberculosis, the beneficial antimicrobial role of IL-1 must be balanced with the need to prevent immunopathology...
  43. pmc The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
    Granulomas, organized aggregates of immune cells, form in response to persistent stimuli and are hallmarks of tuberculosis. Tuberculous granulomas have long been considered host-protective structures formed to contain infection...
  44. doi HIV infection-associated tuberculosis: the epidemiology and the response
    Haileyesus Getahun
    Stop TB Department, World Health Organization, Geneva, Switzerland
    Clin Infect Dis 50:S201-7. 2010
    ..with human immunodeficiency virus (HIV), one-third are estimated to also be infected with Mycobacterium tuberculosis. In 2008, there were an estimated 1...
  45. pmc Tuberculosis and HIV co-infection
    Andrzej Pawlowski
    Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden
    PLoS Pathog 8:e1002464. 2012
    b>Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges...
  46. ncbi American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis
    Henry M Blumberg
    Am J Respir Crit Care Med 167:603-62. 2003
  47. pmc Factors associated with default from treatment among tuberculosis patients in Nairobi province, Kenya: a case control study
    Bernard N Muture
    National Public Health Laboratory Services, Ministry of Health, PO Box 20750 00202, Nairobi, Kenya
    BMC Public Health 11:696. 2011
    Successful treatment of tuberculosis (TB) involves taking anti-tuberculosis drugs for at least six months...
  48. pmc Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection
    Kyle H Rohde
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America
    PLoS Pathog 8:e1002769. 2012
    Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for coping with the pressures encountered inside host cells...
  49. pmc The Mycobacterium tuberculosis regulatory network and hypoxia
    James E Galagan
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Nature 499:178-83. 2013
    We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites ..
  50. pmc Laboratory diagnosis of tuberculosis in resource-poor countries: challenges and opportunities
    Linda M Parsons
    Centers for Disease Control and Prevention, Global AIDS Program, International Laboratory Branch, Atlanta, GA 30329, USA
    Clin Microbiol Rev 24:314-50. 2011
    With an estimated 9.4 million new cases globally, tuberculosis (TB) continues to be a major public health concern. Eighty percent of all cases worldwide occur in 22 high-burden, mainly resource-poor settings...
  51. doi A delicate dance: host response to mycobacteria
    Kassidy K Huynh
    Department of Microbial Pathogenesis, Genentech, Inc, South San Francisco, CA 94080, USA
    Curr Opin Immunol 23:464-72. 2011
    Mycobacterium tuberculosis is an enormously successful human pathogen that can infect its host for decades without causing clinical disease, only to reactivate when host immunity is compromised...
  52. ncbi A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
    Koen Andries
    Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
    Science 307:223-7. 2005
    The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years...
  53. pmc HIV and tuberculosis: a deadly human syndemic
    Candice K Kwan
    Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016 USA
    Clin Microbiol Rev 24:351-76. 2011
    ..The intersection and syndemic interaction between the human immunodeficiency virus (HIV) and tuberculosis (TB) epidemics have had deadly consequences around the world...
  54. doi Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis
    R Diel
    Dept of Pneumology, Medical School Hanover, Hanover, Germany
    Eur Respir J 37:88-99. 2011
    ..TB assays with the tuberculin skin test (TST) for the diagnosis of latent Mycobacterium tuberculosis infection (LTBI)...
  55. doi Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants
    Thomas J Scriba
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, South Africa
    J Infect Dis 203:1832-43. 2011
    BCG, the only licensed tuberculosis vaccine, affords poor protection against lung tuberculosis in infants and children. A new tuberculosis vaccine, which may enhance the BCG-induced immune response, is urgently needed...
  56. pmc Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Infect Dis 204:S1159-67. 2011
    The high burden of tuberculosis (TB) among patients accessing antiretroviral treatment (ART) services in resource-limited settings is a major cause of morbidity and mortality and is associated with nosocomial transmission risk...
  57. pmc Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review
    Stephen D Lawn
    University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:103. 2012
    Detection of Mycobacterium tuberculosis antigens in urine is attractive as a potential means of diagnosing tuberculosis (TB) regardless of the anatomical site of disease...
  58. doi Global tuberculosis control: lessons learnt and future prospects
    Christian Lienhardt
    Stop TB Department, World Health Organization, Desk D4 6017, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Nat Rev Microbiol 10:407-16. 2012
    b>Tuberculosis (TB) is an ancient disease, but not a disease of the past...
  59. pmc High resolution discrimination of clinical Mycobacterium tuberculosis complex strains based on single nucleotide polymorphisms
    Susanne Homolka
    Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
    PLoS ONE 7:e39855. 2012
    Recently, the diversity of the Mycobacterium tuberculosis complex (MTBC) population structure has been described in detail...
  60. pmc Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment
    Anna K Coussens
    Division of Mycobacterial Research, Medical Research Council National Institute for Medical Research, London, United Kingdom
    Proc Natl Acad Sci U S A 109:15449-54. 2012
    ..and antigen-stimulated immune responses in ninety-five patients receiving antimicrobial therapy for pulmonary tuberculosis who were randomized to receive adjunctive high-dose vitamin D or placebo in a clinical trial, and who fulfilled ..
  61. ncbi A single dose of vitamin D enhances immunity to mycobacteria
    Adrian R Martineau
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
    Am J Respir Crit Care Med 176:208-13. 2007
    Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity have not previously been performed.
  62. pmc Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Future Microbiol 6:1067-82. 2011
    ..Following endorsement by the WHO in 2010, we consider the next steps in the implementation of the assay and its potential impact in high burden settings...
  63. doi Interferon-gamma release assays for tuberculosis screening of healthcare workers: a systematic review
    Alice Zwerling
    McGill University and Montreal Chest Institute, Montreal, Canada
    Thorax 67:62-70. 2012
    Healthcare workers (HCWs) are at increased risk of exposure to tuberculosis (TB). Traditionally, screening for latent TB infection (LTBI) is done using the tuberculin skin test (TST)...
  64. pmc HIV-1/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis?
    Collin R Diedrich
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 79:1407-17. 2011
    Human immunodeficiency virus type 1 (HIV) and Mycobacterium tuberculosis have become intertwined over the past few decades in a "syndemic" that exacerbates the morbidity and mortality associated with each pathogen alone...
  65. pmc Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
    Heui Dong Park
    Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 48:833-43. 2003
    Unlike many pathogens that are overtly harmful to their hosts, Mycobacterium tuberculosis can persist for years within humans in a clinically latent state. Latency is often linked to hypoxic conditions within the host. Among M...
  66. pmc HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response
    Salim S Abdool Karim
    Centre for the AIDS Programme of Research in South Africa CAPRISA, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Lancet 374:921-33. 2009
    One of the greatest challenges facing post-apartheid South Africa is the control of the concomitant HIV and tuberculosis epidemics. HIV continues to spread relentlessly, and tuberculosis has been declared a national emergency...
  67. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
    The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family...
  68. doi Dominant TNF-α+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease
    Alexandre Harari
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Nat Med 17:372-6. 2011
    Rapid diagnosis of active Mycobacterium tuberculosis (Mtb) infection remains a clinical and laboratory challenge...
  69. pmc After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection
    Amine Namouchi
    Unite de Genetique Mycobacterienne, Institut Pasteur, 75015 Paris, France
    Genome Res 22:721-34. 2012
    ..Accordingly, Mycobacterium tuberculosis, the deadliest human pathogen, is thought to be clonal and evolve by genetic drift...
  70. pmc Innate immune gene polymorphisms in tuberculosis
    Abul K Azad
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, USA
    Infect Immun 80:3343-59. 2012
    b>Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single infectious agent...
  71. doi Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a metaanalysis
    Roland Diel
    Department of Pulmonary Medicine, Hannover Medical School MHH, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Chest 137:952-68. 2010
    ..1% (95% CI, 0.052-0.071), respectively, among immunosuppressed hosts. The newest commercial IGRAs are superior, in comparison with the TST, for detecting confirmed active TB disease, especially when performed in developed countries...
  72. doi Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis
    M Sester
    Dept of Transplant and Infection Immunology, Saarland University, Homburg, Germany
    Eur Respir J 37:100-11. 2011
    ..release assays (IGRAs) are now established for the immunodiagnosis of latent infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for the diagnosis of active tuberculosis (TB) remains unclear...
  73. pmc Foamy macrophages and the progression of the human tuberculosis granuloma
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Nat Immunol 10:943-8. 2009
    The progression of tuberculosis from a latent, subclinical infection to active disease that culminates in the transmission of infectious bacilli is determined locally at the level of the granuloma...
  74. pmc Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells
    Thomas J Scriba
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Observatory, South Africa
    Eur J Immunol 40:279-90. 2010
    Modified vaccinia Ankara-expressing Ag85A (MVA85A) is a new tuberculosis (TB) vaccine aimed at enhancing immunity induced by BCG...
  75. ncbi Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis
    Michael N Bates
    School of Public Health, University of California, Berkeley, USA
    Arch Intern Med 167:335-42. 2007
    There is no consensus whether tobacco smoking increases risk of tuberculosis (TB) infection, disease, or mortality. Whether this is so has substantial implications for tobacco and TB control policies.
  76. pmc Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa
    Adrian R Martineau
    Division of Mycobacterial Research, National Institute of Medical Research, Mill Hill NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 108:19013-7. 2011
    Vitamin D deficiency is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Europe, but it is not known whether such an association exists among HIV-infected people in subtropical Africa...
  77. ncbi Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    AIDS 21:335-41. 2007
    To determine the burden and impact of immune reconstitution disease (IRD) associated with tuberculosis (TB) among patients initiating antiretroviral treatment (ART) in sub-Saharan Africa.
  78. pmc Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns
    Benjamin M N Kagina
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 182:1073-9. 2010
    Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by measuring the frequency and cytokine expression profile of T cells.
  79. pmc Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival
    Susanne Homolka
    Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
    PLoS Pathog 6:e1000988. 2010
    b>Tuberculosis exerts a tremendous burden on global health, with approximately 9 million new infections and approximately 2 million deaths annually...
  80. pmc Tuberculosis management by private practitioners in Mumbai, India: has anything changed in two decades?
    Zarir F Udwadia
    Department of Respiratory Diseases, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India
    PLoS ONE 5:e12023. 2010
    Mumbai, India. A study conducted in Mumbai two decades ago revealed the extent of inappropriate tuberculosis (TB) management practices of private practitioners...
  81. ncbi Tobacco and tuberculosis: a qualitative systematic review and meta-analysis
    K Slama
    The International Union Against Tuberculosis and Lung Disease, Paris, France
    Int J Tuberc Lung Dis 11:1049-61. 2007
    ..an association between smoking and passive exposure to tobacco smoke and various manifestations and outcomes of tuberculosis (TB)...
  82. ncbi Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005
    Paul A Jensen
    Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Atlanta, GA 30333, USA
    MMWR Recomm Rep 54:1-141. 2005
    In 1994, CDC published the Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in HealthCare Facilities, 1994...
  83. doi New and improved tuberculosis diagnostics: evidence, policy, practice, and impact
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Curr Opin Pulm Med 16:271-84. 2010
    The aim is to summarize the evidence base for tuberculosis (TB) diagnostics, review recent policies on TB diagnostics, and discuss issues such as how evidence is translated into policy, limitations of the existing evidence base, and ..
  84. pmc TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1715-24. 2005
    ..the resistance of TLR9(-/-) as well as TLR2/9 double knockout mice to aerosol infection with Mycobacterium tuberculosis. Infected TLR9(-/-) but not TLR2(-/-) mice displayed defective mycobacteria-induced interleukin (IL)-12p40 and ..
  85. pmc Tuberculosis and diabetes mellitus: convergence of two epidemics
    Kelly E Dooley
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Lancet Infect Dis 9:737-46. 2009
    The link between diabetes mellitus and tuberculosis has been recognised for centuries...
  86. pmc Mycobacterial survival strategies in the phagosome: defence against host stresses
    Sabine Ehrt
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Microbiol 11:1170-8. 2009
    Infections with Mycobacterium tuberculosis remain a major cause of disease and death in humans. Among the factors that contribute to M...
  87. doi Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils
    Xiaoming Zhang
    Institut Pasteur, Unité Régulation Immunitaire et Vaccinologie, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Immunity 31:761-71. 2009
    ..During a chronic infection, neutrophil depletion promoted inflammation and decreased the mycobacterial burden. Therefore, neutrophils can have a previously unsuspected regulatory role during acute and chronic microbial infections...
  88. ncbi Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, South Africa
    AIDS 20:1605-12. 2006
    To determine burden and risk factors for tuberculosis (TB) in an antiretroviral treatment (ART) programme and its impact on ART outcomes.
  89. ncbi Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    John D MacMicking
    Laboratory of Infection Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 302:654-9. 2003
    Interferon-gamma (IFN-gamma) provides an essential component of immunity to tuberculosis by activating infected host macrophages to directly inhibit the replication of Mycobacterium tuberculosis (Mtb)...
  90. pmc Paediatric tuberculosis
    Sandra M Newton
    Department of Paediatrics, Imperial College London, London, UK
    Lancet Infect Dis 8:498-510. 2008
    b>Tuberculosis continues to cause an unacceptably high toll of disease and death among children worldwide, particularly in the wake of the HIV epidemic...
  91. pmc Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 23:1717-25. 2009
    To determine the short-term and long-term risks of tuberculosis (TB) associated with CD4 cell recovery during antiretroviral therapy (ART).
  92. doi Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Cell Host Microbe 6:231-43. 2009
    ..innate immunity have been shown to confer protection against infection with intracellular Mycobacterium tuberculosis. Here, we show that these two antimycobacterial defenses are physiologically linked via a regulatory function ..
  93. ncbi Liquid vs. solid culture for tuberculosis: performance and cost in a resource-constrained setting
    V N Chihota
    Aurum Institute for Health Research, Johannesburg, South Africa
    Int J Tuberc Lung Dis 14:1024-31. 2010
    National Health Laboratory Services tuberculosis (TB) laboratory, South Africa.
  94. pmc Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies
    Haileyesus Getahun
    World Health Organization, Geneva, Switzerland
    PLoS Med 8:e1000391. 2011
    The World Health Organization recommends the screening of all people living with HIV for tuberculosis (TB) disease, followed by TB treatment, or isoniazid preventive therapy (IPT) when TB is excluded...
  95. pmc SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis
    Xiangwei Li
    State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e15831. 2011
    ..The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations.
  96. pmc Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction
    Arun K Mishra
    School of Biosciences, University of Birmingham, Edgbaston, UK
    FEMS Microbiol Rev 35:1126-57. 2011
    Approximately one third of the world's population is infected with Mycobacterium tuberculosis, the causative agent of tuberculosis...
  97. pmc Innate immune recognition of Mycobacterium tuberculosis
    Johanneke Kleinnijenhuis
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    Clin Dev Immunol 2011:405310. 2011
    b>Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem, with 10 million new cases diagnosed each year. Innate immunity plays an important role in the host defense against M...
  98. pmc Interferon-γ release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis
    John Z Metcalfe
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, CA, USA
    J Infect Dis 204:S1120-9. 2011
    The diagnostic value of interferon-γ release assays (IGRAs) for active tuberculosis in low- and middle-income countries is unclear.
  99. doi Three months of rifapentine and isoniazid for latent tuberculosis infection
    Timothy R Sterling
    Vanderbilt University School of Medicine, Nashville, TN, USA
    N Engl J Med 365:2155-66. 2011
    Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and elimination...
  100. pmc Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South Africa
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 51:823-9. 2010
    The World Health Organization (WHO) recommends cough as the trigger for tuberculosis screening in human immunodeficiency virus (HIV)-infected patients, with acid-fast bacillus (AFB) smear as the initial diagnostic test...
  101. doi Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis
    Jose A Caminero
    Servicio de Neumologia, Hospital General de Gran Canaria, Las Palmas, Canary Islands, Spain
    Lancet Infect Dis 10:621-9. 2010
    Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are generally thought to have high mortality rates...

Research Grants78

  1. M. tuberculosis survival in Macrophages
    Richard Friedman; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Central to the disease process in tuberculosis are the interactions of the bacilli with host macrophages...
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..Many have complex mechanisms to rapidly generate diversity in critical antigens. Mycobacterium tuberculosis chronically infects one third of the worlds'population and similarly must avoid clearance by the host ..
  3. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..b>tuberculosis, variola major related pox viruses, Dengue, and West Nile)...
  4. Rinn Song; Fiscal Year: 2016
    ..in the field of pediatric infectious diseases, with a focus on research on internationl health and pediatric tuberculosis. I have a particular interest in improving TB diagnosis and intensified TB case-finding among children with and ..
  5. Roy Curtiss Iii; Fiscal Year: 2016
    ..Paratyphi A, hepatitis B virus (HBV), Streptococcus pneumoniae and Mycobacterium tuberculosis (Mtb) vary widely but may account for about 40 percent of the total deaths with an even greater cost being due ..
  6. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..includes patients with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  7. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..will complete the identification and immunogenicity analyses of all proteins encoded by the Mycobacterium tuberculosis (Mtb) genome, yielding a pool of protective antigens that will immediately enter development as subunit ..
  8. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..cell vaccines against other intracellular organisms with complex life cycles, such as mycobacterial diseases (Tuberculosis, Leprosy, and Buruli ulcer) in which antibiotic resistance is an urgent global threat and vaccines may provide ..
  9. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Pathogens that infect mucosal sites including influenza, tuberculosis, respiratory syncytial virus (RSV), rotavirus, and numerous intestinal parasites and bacteria pose substantial ..
  10. Hardy Kornfeld; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): We are studying the basis for increased tuberculosis (TB) susceptibility in diabetes mellitus (DM). The global population-attributable TB risk conferred by DM equals that of HIV/AIDS...
  11. Richard H Ebright; Fiscal Year: 2014
    ..Myx exhibits potent antibacterial activity against Mycobacterium tuberculosis, Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Enterobacter cloacae, and Clostridium ..
  12. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig J McClain; Fiscal Year: 2012
    ..to develop certain infectious diseases which can complicate HIV, examples being various types of pneumonia and tuberculosis. Moreover, subjects who consume alcohol are more likely to participate in high-risk behaviors that increase the ..
  13. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (Mtb) latently infects one third of the world's population and remains a leading cause of death from a single bacterial infection worldwide...
  14. KATHERINE YUDEH KING; Fiscal Year: 2014
    ..interventions for myelosuppression as a result of chronic infections such as severe viral infections and tuberculosis. Research Career Development Plan: I will utilize an array of educational and research resources in Houston to ..
  15. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..Eduardo Groisman, WU, and Dr. Yixin Shi, Univ. Arizona-Tempe);(6) Mycobacterium tuberculosis cell wall lipid molecular species and cellular mechanisms of destructive host tissue reactions in a murine ..
  16. Joseph Heitman; Fiscal Year: 2016
    ..It is now a greater cause of AIDS related morbidity in Africa than tuberculosis. C...
  17. Effect Ultraviolet Radiation on Latent M. tuberculosis Infection in Guinea Pigs
    Amminikutty Jeevan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tuberculosis, caused by Mycobacterium tuberculosis, continues to be a public health problem in many countries including the United States because of its prevalence in HIV-infected patients and also ..
  18. STRUCTURE-BASED TUBERCULOSIS DRUG DESIGN TARGETED AT ACYL-COA CARBOXYLASE
    Shiou Chuan Tsai; Fiscal Year: 2010
    ..DO NOT EXCEED THE SPACE PROVIDED. Mycobacterium tuberculosis, the pathogen of tuberculosis (TB), has a cell envelope with chemically complex lipids that are closely related ..
  19. Chi Huey Wong; Fiscal Year: 2014
    ..In extension, the Mycobacterial TGase will be established for the development of anti-tuberculosis agents, which are in great need due to the alarming rise of multi- and extensively-drug resistant Mycobacterium ..
  20. Dana Boyd; Fiscal Year: 2014
    ..Many other bacteria, including Mycobacterium tuberculosis (Mtb), appear to use a homologue of human vitamin K epoxide reductase, VKOR, for disulfide bond formation ..
  21. Crystalline Endolysin Treatment for Tuberculosis in TB/HIV co-infected patients
    BHAMI C SHENOY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Though often considered to be a disease of the past, tuberculosis (TB) is still a leading killer of people worldwide...
  22. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..but under adverse conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis...
  23. Richard F Silver; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Tuberculosis (TB) remains a significant threat to international public health, as over 2 million individuals die of the disease each year...
  24. JAVEED ALI SHAH; Fiscal Year: 2016
    ..provided by applicant): The applicant is a specialist in infectious diseases with a long-term interest in tuberculosis and international health. His background in cellular immunology is the basis for the proposed research...
  25. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..There is emerging consensus that vaccines against complex pathogens like HIV, M. tuberculosis, and Plasmodium will require both antibodies and CD8 T cells...
  26. Maurizio Del Poeta; Fiscal Year: 2014
    ..exceed 650,000/year, making HIV-associated deaths caused by cryptococcosis more frequent than those caused by tuberculosis. Pneumocystis infection remains the most common serious opportunistic illness in HIV-infected persons15 with a ..
  27. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tuberculosis (TB) is a chronic infectious disease caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)...
  28. Acquisition of a MALDI-TOF/TOF MS for Glycomic and Lipidomic Research
    Larry S Schlesinger; Fiscal Year: 2010
    ..The major research activities described involve: i) Mycobacterium tuberculosis (M...
  29. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..but under adverse conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis...
  30. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..The results are likely to be beneficial for not only patients with scleroderma, but also patients with asthma, sepsis, and tuberculosis, in all of which IL-442 has been suggested to play a significant role.
  31. Sanjay Tyagi; Fiscal Year: 2016
    ..Our proposal aims at developing a test that provides tuberculosis (TB) diagnosticians with the critical ability to distinguish stable latent Mycobacterium tuberculosis infection ..
  32. Coenzyme F420-dependent enzymes in mycobacteria
    Biswarup Mukhopadhyay; Fiscal Year: 2013
    ..This phylum includes Mycobacterium tuberculosis and Mycobacterium leprae, which cause tuberculosis (TB) and leprosy, respectively, and Streptomyces, Nocardia, ..
  33. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2012
    ..this parasite mechanism in human infections caused by Leishmania and other pathogens that live inside cells (tuberculosis, malaria, and toxoplasmosis)...
  34. Alicia Hsin Ming Chang; Fiscal Year: 2015
    DESCRIPTION (provided by applicant: Despite scientific and programmatic advances, tuberculosis (TB) continues to be the leading cause of death in the world from a curable infection, making TB prevention a continuing health priority...
  35. Effect of D-cycloserine on treatment of PTSD in youth
    Michael S Scheeringa; Fiscal Year: 2010
    ..Accordingly, there is a need for treatment advances. D-cycloserine (DCS), an antibiotic used to treat tuberculosis and urinary tract infections, is a partial agonist at the glycine modulatory site of the N-methyl- D-aspartic ..
  36. Hong Li; Fiscal Year: 2015
    ..are found in medically important bacteria that include but not limited to Yersinia pestis, Mycobacterium tuberculosis, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitides, Vibrio vulnificus, Staphylococcus aureus, ..
  37. Arthur L Reingold; Fiscal Year: 2016
    ..great importance as a cause of morbidity and mortality in Zimbabwe, research and research training related to tuberculosis (TB) will be given high priority, especially when directly linked to ongoing UZ-UCSF collaborative studies of ..
  38. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    ..such as carbon-11 (11C) and fluorine-18 (18F), will be incorporated into current antibiotics, such as the tuberculosis drugs isoniazid and rifampicin, in order to directly identify the protein target(s) for these molecules in ..
  39. Robert T Batey; Fiscal Year: 2015
    ..pathogens including Listeria monocytogenes, Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis making them of great interest as novel targets for designing antimicrobial therapeutics...
  40. Anne Goldfeld; Fiscal Year: 2016
    ..diabetes, eczema, lupus, several different forms of cancer, and multiple infectious diseases including sepsis, tuberculosis (TB), and HIV-1...
  41. Tb-FISH (Fluorescent in Situ Hybridization) Assay for Direct Detection of M. tube
    JYOTSNA S SHAH; Fiscal Year: 2010
    ..TB-FISH is Dual Probe Fluorescent In-Situ Hybridization assay for detecting and differentiating Mycobacterium tuberculosis complex (MTB) ribosomal RNA (rRNA) and Mycobacterium species (rRNA) on a SINGLE methanol fixed smear, prepared ..
  42. Mary Jackson; Fiscal Year: 2016
    ..poorly defined roles in mycobacterial physiology and are important immunomodulatory molecules in the course of tuberculosis and leprosy as well as key ligands promoting the entry of mycobacteria into phagocytic and non-phagocytic cells...
  43. Edward D Chan; Fiscal Year: 2015
    ..project is to elucidate the mechanisms by which interleukin-32 (IL-32) enhances immunity against Mycobacterium tuberculosis (MTB)...
  44. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..Mycobacterium tuberculosis and Schistosoma mansoni represent epidemic pathogens for which vaccine development has been difficult to ..
  45. Chetan Seshadri; Fiscal Year: 2014
    The applicant is a specialist in infectious diseases with a long-term interest in tuberculosis and international health. His background in basic and clinical research is the basis for the proposed research...
  46. Jeffrey K Griffiths; Fiscal Year: 2016
    ..using an inexpensive, efficient approach testing thousands of specimens - by re-screening sputa collected for tuberculosis testing for Cr. This group is enriched with persons with HIV...
  47. CHRISTINA A FISKE; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Tuberculosis (TB) is a global health emergency. The World Health Organization estimated that approximately 9.3 million people worldwide were diagnosed with TB in 2007 and 2 million persons died...
  48. Measuring Tobacco Mortality within the Million Death Study in India
    Prabhat Jha; Fiscal Year: 2010
    ..equal to that seen in the United States about two decades ago);and (iv) smoking causes nearly half of tuberculosis deaths in India...
  49. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The pathophysiology of tuberculosis (TB) is linked to the ability of the causative organism, Mycobacterium tuberculosis (M.tb), to grow within human macrophages...
  50. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    Air pollution and tuberculosis (TB) each present major challenges to public health and specifically to lung health globally...
  51. NICHD INTERNATIONAL & DOMESTIC PEDIATRIC &MATERNAL HIV STUDIES COORDINATING CTR
    CAROL NESEL; Fiscal Year: 2013
    ..In populations of women and children, research gaps related to HIV-associated co-infections such as tuberculosis (TB), hepatitis, and malaria have emerged as HIV research has become increasingly global in nature...
  52. Mycobacterium tuberculosis carbon metabolism in vivo
    John D McKinney; Fiscal Year: 2010
    ..which catalyze the first unique reaction in the glyoxylate cycle, are jointly required for Mycobacterium tuberculosis (MTB) growth, survival, and virulence in vivo...
  53. Proteome-wide screen for M. tuberculosis antigens
    Robert N Husson; Fiscal Year: 2010
    Current approaches to the diagnosis of tuberculosis (TB) are not optimal. The tuberculin skin test has low sensitivity and specificity...
  54. Paul R Ortiz de Montellano; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The three most important research needs for progress in the treatment of tuberculosis are to (a) develop drugs against drug resistant strains of Mycobacterium tuberculosis, (b) develop effective ..
  55. A Fluorescence Polarization Assay for Fatty Acid Adenylating Enzymes
    Courtney C Aldrich; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is the leading cause of bacterial infectious disease mortality. The cell envelope of M...
  56. Deciphering of the Toxin-Antitoxin Systems in E. coli
    Masayori Inouye; Fiscal Year: 2012
    ..Surprisingly, many bacteria, particularly human pathogens such as Mycobacterium tuberculosis contain a large number of independent toxin genes on their genomes...
  57. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..Recent data from intracellular pathogens (i.e. Mycobacterium tuberculosis, Listeria monocytogenes) and other fungi (i.e...
  58. Philippe Gros; Fiscal Year: 2015
    ..Mycobacterial infections continue to be a serious health threat, causing tuberculosis in otherwise healthy individuals, and causing disseminated infections in immuno-suppressed patients...
  59. Randall K Holmes; Fiscal Year: 2014
    ..b>Tuberculosis, which causes more deaths worldwide than any other bacterial infection, is a paradigm for intracellular ..
  60. Sergei P Atamas; Fiscal Year: 2014
    ..of immune homeostasis and in various immune-mediated diseases including but not limited to asthma, allergies, tuberculosis, and autoimmunity-associated interstitial lung disease (scleroderma, rheumatoid arthritis, poly- and ..
  61. Novel Spectinamide Antibiotics for the Treatment of MDR/XDR Tuberculosis
    Michelle M Butler; Fiscal Year: 2013
    ..provided by applicant): The overall objective of this project is to further develop a novel chemical class of tuberculosis (TB) therapeutic agents, the spectinamide series, for use against MDR and XDR strains of Mycobacterium ..
  62. Gregory P Bisson; Fiscal Year: 2014
    ..by applicant): Nearly 2 billion people, one third of the World's population, are at risk of active tuberculosis (TB) because they are latently infected with the causative agent Mycobacterium tuberculosis (Mtb), and almost 2 ..
  63. Ailong Ke; Fiscal Year: 2015
    ..as Campylobacter human jejuni, Clostridium botulinum, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis and Yersinia pestis. It has been shown to modulate the horizontal gene transfer and biofilm formation...
  64. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2004
    Disseminated infection (mycobacteremia) with Mycobacterium tuberculosis (dMTB) has been documented by our group in 10-25 percent of patients with HIV infection in Africa using lysis- centrifugation blood cultures...
  65. TB- FISH Assay for Direct Detection of M. tuberculosis in unprocessed sputum
    Jyotsna Shah; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Tuberculosis is a disease of the poor. Between 80-90% of active tuberculosis (TB) is due to pulmonary tuberculosis. Individuals with pulmonary disease are highly contagious...
  66. The effect of pncA expression and POA efflux rate in the level of PZA-resistance
    Mirko J Zimic; Fiscal Year: 2010
    ..is one of the most important antituberculous drugs because it shortened the course of treatment for tuberculosis. It is still the most effective drug against the latent stage of Mycobacterium tuberculosis but its mechanism ..
  67. Investigation of synergy between Rifampin and SQ109, a new anti-TB drug candidate
    VENKATA REDDY; Fiscal Year: 2009
    ..SQ109 was selected out of the library of 63,238 compounds, because it is highly efficacious in killing M. tuberculosis within infected macrophages and in experimental animals, has relatively low cytotoxicity in cultured mammalian ..
  68. Macaque model of TB/AIDS co-infection via natural routes of exposure
    Deepak Kaushal; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tuberculosis (TB) and Acquired Immune Deficiency Syndrome (AIDS), together, lead to the death of more than four million people annually, world-wide...
  69. A New Target for Anti-tuberculosis Agents, FAS 1
    John Welch; Fiscal Year: 2003
    As a sentinel disease for the diagnosis of AIDS, early reports of tuberculosis complicating AIDS seemed to indicate the disease was a result of reactivation of a previous infection, however today the picture of tuberculosis as a ..
  70. M TUBERCULOSIS SURVIVAL IN MACROPHAGES
    Richard Friedman; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Applicant's Abstract): The infection of macrophages by Mycobacterium tuberculosis can be divided into four steps: adherence, entry, intracellular survival, and multiplication...
  71. A New Tuberculin for the Diagnosis of Tuberculosis
    Leo Einck; Fiscal Year: 2001
    DESCRIPTION (provided by applicant):Accurate diagnosis of tuberculosis (TB) infection is one of the pillars of effective TB control programs...
  72. DEVELOPMENT AND TESTING OF NEW TUBERCULOSIS VACCINES
    MARCUS AARON HORWITZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis, the primary agent of tuberculosis, kills 2 million people annually, making it one of the world's leading causes of death...
  73. Genomic and immunological comparisons of M africanum and M tuberculosis
    Bouke C de Jong; Fiscal Year: 2010
    ..de Jong moved to the Gambia in 2003. Her intention was to identify M. tuberculosis strains particularly well suited for transmission and cavitation;however a fortuitous split between M...
  74. Rapid High-Throughput Mycobacterium Tuberculosis Genotyping
    Christian Massire; Fiscal Year: 2009
    Preventing the spread of multidrug-resistant and extreme multidrug-resistant strains of Mycobacterium tuberculosis (MDR/XDR) is an important public health problem...
  75. Discovery of novel agents against M. tuberculosis.
    ESTEBAN EDWARD MENA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Despite the fact that tuberculosis is a major public global health problem, there have been no drugs developed for it since the 1960s. In 2006 tuberculosis caused 1...